2005

Nucleic acidsU 0700 Synthesis and Biological Evaluation of Novel 1'-Branched and Spironucleosides

Analogues. — The anionic reactivity of the cyano function and especially the addition of organolithium reagents both to protected bromo uridine and 2'-deoxy uridine deriv-atives is investigated as well as the antiviral and antitumoral activity of some of the new anomeric spironucleosides and of 2',3'-didehydro-2',3'-dideoxy nucleoside (IX), a structural analogue of known anti-HIV agents. None of the compounds reveals antiviral activity, however, spironucleoside (IV) and didehydronucleoside (IX) display cytostat-ic activity against murine leukemia and human T-lymphocyte cells. — (CHATGILIALOGLU, C.; FERRERI, C.; GIMISIS*, T.; ROBERTI, M.; BALZARINI, J.; DE CLERCQ, E.; Nucleosides, Nucleotides Nucleic Acids 23 (2004) 10, 1565-1581; Lab. Org. Chem., Univ. Athens, GR-15771 Athens, Greece; Eng.) — H. Hoennerscheid

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