synthesis and biological evaluation of new thiazolyl/benzothiazolyl-amides, derivatives of...

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2006 Antiinflammatory activity X 0130 Synthesis and Biological Evaluation of New Thiazolyl/benzothiazolyl-amides, Derivatives of 4-Phenyl-piperazine. — The title compounds are tested as antiinflam- matory agents by using the carrageenin mouse paw oedema model. In general (I) and (II) are found to be highly efficient and do not present any side effects from the gas- trointestinal route. Derivative (Id) is the most potent derivative within the series. — (PAPADOPOULOU, C.; GERONIKAKI*, A.; HADJIPAVLOU-LITINA, D.; Farmaco 60 (2005) 11-12, 969-973; Dep. Pharm. Chem., Sch. Pharm., Aristotle Univ., GR-54006 Thessaloniki, Greece; Eng.) — K. Woydowski 10- 235

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Page 1: Synthesis and Biological Evaluation of New Thiazolyl/benzothiazolyl-amides, Derivatives of 4-Phenyl-piperazine

2006

Antiinflammatory activityX 0130 Synthesis and Biological Evaluation of New Thiazolyl/benzothiazolyl-amides,

Derivatives of 4-Phenyl-piperazine. — The title compounds are tested as antiinflam-matory agents by using the carrageenin mouse paw oedema model. In general (I) and (II) are found to be highly efficient and do not present any side effects from the gas-trointestinal route. Derivative (Id) is the most potent derivative within the series. — (PAPADOPOULOU, C.; GERONIKAKI*, A.; HADJIPAVLOU-LITINA, D.; Farmaco 60 (2005) 11-12, 969-973; Dep. Pharm. Chem., Sch. Pharm., Aristotle Univ., GR-54006 Thessaloniki, Greece; Eng.) — K. Woydowski

10- 235