symchem product list nov 2011

SYMCHEM Research Labs Pvt Limited

Adj to F 6, Road No 18, IDA Nacharam,Hyderabad- 500076 INDIA

Tel Fax : 91-40-27176491 email : [email protected] website : symchem.com

MISSION “To build a world class custom synthesis and contract manufacturing company that uses its own R&D and can deliver products conforming to highest standards of process validation using optimal resources and with equal emphasis on technology, quality, safety with a NO COMPROMISE attitude on ethical , ecological , moral and social values” SYMCHEM serves Pharma and Chemical industries in the following areas : Custom Synthesis Synthesized compounds involving variety of chemistries and exported to Europe and USA. Impurity Synthesis Impurity synthesis and exporting to European countries. Process Research & Development Multi-steps Chemical process develop for large Indian pharma company. Chemistry performed Amino acid. Carbohydrate Chemistry and synthesis of Pyridine & Imidazole derivatives. Compounds were sold to Indian clients and exported.




Heterocyclic Compound

6-Bromopicolinic acid

21190-87-4

NHOOC Br

2-Bromo-6-methylpyridine 5315-25-3

NCH3 Br

2-Amino-6-methylpyridine 1824-81-3

NCH3 NH2 4-Amino-3-nitropyridine

1681-37-4

N

NH2

NO2

4-Hydroxy-3-nitropyridine 5435-54-1

N

OH

NO2

3,4-Diaminopyridine 54-96-6

N

NH2

NH2

3-Methyl-4-nitropyridine

1678-53-1

N

NO2

CH3

3-Aminopyridin-4-ol 6320-39-4

N

OH

NH2

4-Amino-3-methylpyridine 1990-90-5

N

NH2

CH3

4-Ethylpyridin-2-amine 33252-32-3

N

CH3

NH2

2-Bromo-6-methylpyridine 5315-25-3

NCH3 Br

2-Pyridinamine, 6-chloro-5-methyl

442129-37-5

N

CH3

NH2 Cl 4-Amino-5-methyl-3-

nitropyridine 18227-67-3

N

NH2

NO2CH3

3,6-Dichloropyridazine 141-30-0

NNCl

Cl

3,6-Diiodopyridazine 20698-04-8

NNI

I

3,6-Dibromopyridazine 17973-86-3

NNBr

Br

4,5-Pyridazinediamine 28682-70-4

NN

NH2

NH2

2-Chloro-3-methylquinoxaline

32601-86-8 N

N

Cl

CH3 Furo[3,4-B]Pyridin-5(7h)-One

5657-51-2

N-(Diphenylmethylene)glycine ethyl ester 69555-14-2

NO

O

CH3

2-Hydroxytetrahydrofuran 5371-52-8 O OH




API IMPURITIES

Name CAS No. API Structure

N-Desmethyl Sildenafil

139755-82-1 Sildenafil

Thio Sildenafil 479073-79-5 Sildenafil

Simvastatin Hydroxy Acid Ammonium Salt

139893-43-9 Simvastatin

HCH3

OO

CH3

CH3

CH3

OH

OOH

CH3O

- NH4

+

Tauroursodeoxycholic Acid

14605-22- 2 Tauroursodeoxycholic Acid

Rosuvastatin Lactone

503610-43-3 Rosuvastatin

N

NN

O

O

OH

S

CH3

CH3 O

O

CH3

CH3

F N-acetyl mesalamine

51-59-2 Mesalamine

COOHOH

NH

O

Rabeprazole Sulfone

117976-47-3 Rabeprazole

NH

N SO

N

O

O

O




Name CAS No. API Structure 2-Pyridyl acetic Acid

13115-43-0 Betahistine

N O

OH

25-Des Acetyl Rifampicin

16783-99-6 Rifampicin

Dihydralazine Sulphate Impurity A

Dihydralazine Sulphate

NN

NH2

NHNH2

Dihydralazine Sulphate Impurity C

Dihydralazine Sulphate

NN

NHNH2

Ramiprilate; Ramipril Diacid ; (EP Impurity E)

87269-97-4 Ramiprile

NHO

N

H

HO

OH CH3

HOOC

Ramiprile

diketopiperazine (EP Impurity D)

108731-95-9

N

O

NH

H

O

O

CH3

CH3

O

O-Desmethyl Tramadol

16412-54-7 Tramadol

OH

N

OH





Lovastatin Hydroxy Acid Sodium Salt

75225-51-3 Lovastatin

HCH3

O

O

CH3

CH3

CH3

O-

OOH

OH

Na+

Lovastatin Hydroxy Acid Ammonium Salt Salt

237073-64-2 Lovastatin

HCH3

O

O

CH3

CH3

CH3

O-

OOH

OH

NH4+

Montelukast DCHA 577953-88-9 Montelukast

Montelukast Acid 158966-92-8 Montelukast

N-Desmethyl Olanzapine

Olanzapine

Atorvastatin Lactone

125995-03-1

Atorvastatin Lactone

CH3

NH N

OCH3

F

O

O

OH

3-OH Desloratidine 119410-08-1 Desloratidine

N

NH

Cl OH 25-Des Acetyl Rifabutene

100324-63-8 Rifabutene





Lansoprazole Impurity D; 1H-Benzimidazol-2-ol ; 2-Hydroxybenzimidazole

615-16-7 Lansoprazole

NH

NOH

Lansoprazole Impurity E ; 1H-Benzimidazol-2-thiol ; 2-Mercaptobenzimidazole

83-39-1 Lansoprazole

NH

NSH

API IMPURITIES

(Proposed to Synthesis Pharma Impurity of following API as per requirement of Client)

Sr No Name Sr No Name 1 Enalapril Maleate 19 Pitavastatin 2 Fosinopril 20 Pravastatin 3 Lisinopril 21 Rosuvastatin 4 Quinalpril 22 Candesartan 5 Ramipril 23 Eletriptan 6 Trandolapril 24 Eprosartan 7 Benazepril 25 Irbesartan 8 Dapoxetine 26 Losartan 9 Aripiprazole 27 Olmesartan

10 Fluconazole 28 Telmesartan 11 Lansoprazole 29 Valsartan 12 Omeprazole 30 Duloxetine 13 Pentaprazole 31 Imatinib 14 Rabeprazole 32 Montelucast 15 Atorvastatin 33 Oxybutynin chloride 16 Fluvastatin 34 Rizatriptan 17 Lovastatin 35 Pioglitazone 18 Mevastatin 36 Rosiglitazone




List of Pesticide Impurity

Name Pesticide Structure

2-Amino-N-(1-methylethyl)benzamide

Bentazone

NH2

NH

O

CH3

CH3

[2-[[(1-methylethyl)-amino]carbonyl] phenyl] sulfamic acid

Bentazone

NH

NH

O

CH3

CH3

SO3H 4-({4-[(Dimethoxyphosphorothioyl)-oxy]phenyl}thio)phenyl dimethyl phosphate (Temephos oxon)

Temephos

S

OOP P

O

OS

S

O

O

CH3

CH3

CH3

CH3

O-{4-[(4-{[Methoxy(methylthio)-phosphoryl]oxy}phenyl)thio]phenyl}-O,O-dimethyl thiophosphate (Iso-temephos)

Temephos

S

OOP P

O

OO

S

O

O

CH3

CH3

CH3

CH3

N–(1 –methyl propyl) – 3,4 Xylidine

Pendimethalin NH

CH3CH3

CH C2H5CH3

N–(1 –Ethyl propyl) – 2,3 Xylidine

Pendimethalin NH

CH3

CH C2H5C2H5

CH3

3,4-Dimethyl 2,6-dinitro aniline

Pendimethalin

CH3CH3

NH2O2N NO2

N-Nitroso Pendimethalin

Pendimethalin

CH3CH3

O2N NO2

N-CH-(CH2CH3)2

NO

N–(1 –Ethyl propyl) – 6-nitro 3,4 Xylidine

Pendimethalin NH

CH3CH3

CH C2H5C2H5

O2N

D,L,N-(2,6-dimethyl-phenyl)-N-(2'-chloroacetyl)-alanine methyl ester [DMPCAME]

Metalaxyl

CH3

N

CH3

CH3

O

O

ClCH3

O




Symchem Research Labs Pvt Limited aims to be the best and foremost contract research organization committed to serve the pharmaceutical industry worldwide with high quality standards, at par with the international regulatory and professional expectations. Symchem is established in Hyderabad, India by professionally qualified and experienced personnel. Symchem is committed to maintain total confidentiality, intellectual property protection and supports clients in cost containment. Symchem is actively involved in developing alternate, patent non-infringing processes for APIs, for the inventors to manage late life cycle and leading generic drug manufacturers. With years of experience, experimentation and application, the scientists at Symchem are the right people to be tapped for contract research projects. The Research team is specialized in process design for new drug candidates, its development up to gram/kilo scale, structural elucidation, impurity profile studies, process validation, and process optimization. At Symchem we believe that results are important; but we also believe in “The way we achieve results” is equally important. Our commitment to this principle is the key to sustain client’s trust and confidence in our company. Symchem Research Labs Pvt Ltd, is located in Hyderabad, India, wholly owned by its founder, Surendra Pandey, Ph D. Symchem is a R&D organization that focuses on process development and manufacturing of fine organic chemicals and drug substances. Symchem helps their clients by supporting them in Drug Development, Custom Synthesis ,Process Research, Pilot-Scale Manufacturing, cGMP Manufacturing. Symchem has standard as well as specialty organic laboratory capabilities. Contact Us Symchem Research Labs Private Limited Surendra Pandey, Ph.D. Managing Director Cell : +91-9963220006 E-link : [email protected] Adj to F-6, Road No 18, IDA Nacharam, Hyderabad 500 076 India Tel : +91-40-27176491 Fax : +91-40-27176491 E-link : [email protected]

symchem product list nov 2011

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