susceptibility towards formaldehyde-induced genotoxicity by günter speit
TRANSCRIPT
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
1/19
EGF@E"1>:1 Kh|gq U~g`| :
Uwueg~|`a`i`|p |m{jqlu fmqbjilgcplg"`hlwegl kghm|ms`e`|p
Kh|gq U~g`|
Wh`vgqu`|| Wib
@hu|`|w| fq Cwbjhkghg|`oL"30>60 Wib #Kgqbjhp)
kwgh|gq(u~g`|Nwh`"wib(lg
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
2/19
EGF@E"1>:1 Kh|gq U~g`| 1
Uwueg~|`a`i`|p |m{jqlu fmqbjilgcplg"`hlwegl kghm|ms`e`|p
Mw|i`hg mf |cg ~qgugh|j|`mh4
@( @h|qmlwe|`mh
@@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p
@@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u
@V( ^mipbmq~c`ubu h |cg FLC kghg jhl uwueg~|`a`i`|p
V( Uwbbjqp
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
3/19
EGF@E"1>:1 Kh|gq U~g`| 5
@( @h|qmlwe|`mh
Uwueg~|`aig uwakqmw~u jqg kqmw~u mf `hl`v`lwjiu
{`|c ~qgl`u~mu`|`mh |m kqgj|gq qgu~mhug |m jh gs~muwqg4
Kghg|`eu #g(k( kghg|`e ~mipbmq~c`ubu)
Kghlgq l`ffgqghegu
I`fg u|jkgu #g(k( ec`ilqgh)
Cgji|c u|j|wu #g(k( ju|cbj|`eu)
I`fgu|pig fje|mqu
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Gs~muwqg |m m|cgq ecgb`ejiu
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
4/19
EGF@E"1>:1 Kh|gq U~g`| >3)4
Gs~muwqg i`b`| ucmwil gu~ge`jiip emhu`lgq ~muu`aig `h|gq"`hl`v`lwjil`ffgqghegu `h uwueg~|`a`i`|p |m `qq`|j|`mh ap FJ(
\cg eq`|`eji cgji|c gffge| mf gs~muwqg |m FJ `u |cg ~m|gh|`ji
|m `hlweg ejhegq `h |cg w~~gq qgu~`qj|mqp |qje|(
\cgqg `u hm qgjumh |m juuwbg |cj| uwakqmw~u {`|c `heqgjugl uwueg~|`a`i`|p
|m `qq`|j|`mh bjp jium cjvg j c`kcgq q`uo fmq |cg `hlwe|`mh mf bw|j|`mhu
jhl ejhegq aw| lj|j jqg hm| jvj`ijaig(
[g `hvgu|`kj|gl |cg `h v`|qm kghm|ms`e uwueg~|`a`i`|p mf aimml egiiu
`h qgij|`mhuc`~ |m hjuji ughu`|`v`|p(
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
5/19
EGF@E"1>:1 Kh|gq U~g`| 7
Egiiwijq lgfgheg jkj`hu| FJ"`hlwegl bw|jkgh`e`|p
fmqbjilgcplg
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kiw|j|c`mhg
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jllwe| fmqbj|`mh
HJL/HJLC /C/
C1M1
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HJL/HJLC /C/
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HJLC /C/
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FLCJILC:J:JILC1 ej|jijug
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@heqgjugl uwueg~|`a`i`|p bjp ag lwg |m4
" `b~j`qgl bg|jami`e `hje|`vj|`mh
" `b~j`qgl LHJ qg~j`q
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
6/19
EGF@E"1>:1 Kh|gq U~g`| 6
@@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p
U|wlp lgu`kh4
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
7/19
EGF@E"1>:1 Kh|gq U~g`| ;
@@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p
Aimml ujb~igu {gqg gs~mugl |m FJ `h v`|qm4
Embg| juujp {ju ~gqfmqbgl |m bgjuwqg" FJ"`hlwegl LHJ ljbjkg #L^S)
" qgbmvji #qg~j`q) mf FJ"`hlwegl L^S
UEG"|gu| {ju ~gqfmqbgl |m bgjuwqg
" ~gqu`u|gheg mf FJ"`hlwegl LHJ ljbjkg
" FJ"`hlwegl kghm|ms`e`|p #UEG)
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
8/19
EGF@E"1>:1 Kh|gq U~g`| 3
@@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p
Qguwi|u4
Ijqkg l`ffgqghegu `h EM1"ughu`|`v`|p #hjuji `qq`|j|`mh)
Hm u`kh`f`ejh| l`ffgqghegu ag|{ggh |cg uwakqmw~u
" {`|c qgkjql |m |cg `hlwe|`mh mf kghm|ms`e gffge|u #L^S UEG)
" {`|c qgkjql |m |cg ~qm|ge|`mh jkj`hu| FJ #FLC? L^S"qg~j`q)
Tgiigq g| ji( Bw|j|( Qgu( ;15 ::":; #1>::)
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
9/19
EGF@E"1>:1 Kh|gq U~g`| 0
@@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p
Emqqgij|`mh jhjipu`u fmq jii ~jqjbg|gqu |gu|gl4
" fmq jii uwadge|u
" fmq |cg uwakqmw~u mf cp~gqughu`|`vg jhl cp~mughu`|`vg uwadge|u
" fmq |cg uwakqmw~u mf gs|qgbip cp~gqughu`|`vg jhl cp~mughu`|`vg uwadge|u(
Qguwi|u4
Hm emqqgij|`mh ag|{ggh EM1"ughu`|`v`|p jhl |cg gs~qguu`mh mf FLC(
Hm emqqgij|`mh ag|{ggh EM1"ughu`|`v`|p jhl `hl`ej|mqu mf egiiwijq ughu`|`v`|p(
Hm uwakqmw~ {`|c ~jq|`ewijq bw|jkgh ughu`|`v`|p|m{jqlu FJ {ju `lgh|`f`gl(
Tgiigq g| ji( Bw|j|( Qgu( ;15 ::":; #1>::)
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
10/19
EGF@E"1>:1 Kh|gq U~g`| :>
@@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u
Gs"v`vm uwueg~|`a`i`|p |m{jqlu FJ"`hlwegl kghm|ms`e`|p {ju |gu|gl4
" `h 5> bjig ubmogqu
" `h 5> fgbjig hmh"ubmogqu
" `h 5> uecmmi ec`ilqgh
\cg embg| juujp jhl |cg UEG"|gu| {gqg ~gqfmqbgl
`h jeemqljheg {`|c |cg ~qgv`mwu u|wlp(
\cg gs~qguu`mh mf |cg FLC"kghg {ju bgjuwqgl
ap zwjh|`|j|`vg qgji"|`bg Q\"^EQ(
^mipbmq~c`ubu `h KU\B: jhl KU\\: {gqg emhu`lgqgl(
Tgiigq g| ji( Jqec( \ms`emi( `h ~qguu #1>:1)
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
11/19
EGF@E"1>:1 Kh|gq U~g`| ::
@@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u
Hm a`mimk`ejiip qgigvjh| l`ffgqghegu ag|{ggh |cg |cqgg kqmw~u(
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
12/19
EGF@E"1>:1 Kh|gq U~g`| :1
@@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u
LHJ ljbjkg
LHJ qg~j`q
UEG"|gu|
FLC
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
13/19
EGF@E"1>:1 Kh|gq U~g`| :5
@@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u
@hlwegl kghm|ms`e gffge|u #embg| juujp) jqg hm| juume`j|gl
{`|c ~mipbmq~c`ubu `h KU\B: jhl KU\\:(
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
14/19
EGF@E"1>:1 Kh|gq U~g`| ::1 Kh|gq U~g`| :6
@V( ^mipbmq~c`ubu `h |cg FLC kghg jhl uwueg~|`a`i`|p
Dwu| g| ji( \ms`emi( Ig||( 1>; :1:":1; #1>::)
[g `lgh|`f`gl |cqgg UH^u `h |cg FLC"kghg #JLC7) {`|c j ~m|gh|`ji `b~je|
mh kghg gs~qguu`mh #HEA@ lj|jajug)(
Hm vjq`jh| jiigi {ju lg|ge|gl fmq 1 UH^u `h mwq u|wlp ~m~wij|`mh(
30 Uwadge|u {`|c j vjq`jh| jiigig {gqg `lgh|`f`gl fmq qu:5351 #gsmh 0)(
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
17/19
EGF@E"1>:1 Kh|gq U~g`| :;
@V( ^mipbmq~c`ubu `h |cg FLC kghg jhl uwueg~|`a`i`|p
\cg vjq`jh| jiigig l`l hm| ejwug j l`ffgqgheg
`h FLC gs~qguu`mh #bQHJ igvgi)(
\cg vjq`jh| jiigig l`l hm| ejwug j l`ffgqgheg
`h |cg ~qm|ge|`mh mf egiiu jkj`hu| FJ"`hlwegl
kghm|ms`e`|p #embg| juujp)4
" Hm l`ffgqgheg `h ajeokqmwhl LHJ gffge|u
" Hm l`ffgqgheg `h FJ"`hlwegl L^S
Hm `hl`ej|`mh fmq `h|gq"`hl`v`lwji l`ffgqghegu
`h |cg bg|jami`e `hje|`vj|`mh mf FJ(
Dwu| g| ji( \ms`emi( Ig||( 1>; :1:":1; #1>::)
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
18/19
EGF@E"1>:1 Kh|gq U~g`| :3
Uwueg~|`a`i`|p |m{jqlu FJ"`hlwegl kghm|ms`e`|p
Uwbbjqp
Mwq u|wlp l`l hm| qgvgji j ~mipbmq~c`ub mf FLC {c`ec b`kc| jffge|
kghg gs~qguu`mh jhl igjl |m `h|gq"`hl`v`lwji l`ffgqghegu
`h |cg ~qm|ge|`mh mf FJ"`hlwegl #kghm")|ms`e`|p(
Ji|mkg|cgq mwq u|wl`gu lm hm| ~m`h| |m qgigvjh| l`ffgqghegu
`h uwueg~|`a`i`|p |m{jqlu FJ"`hlwegl kghm|ms`e`|p
{c`ec hggl |m ag emhu`lgqgl `h q`uo juuguubgh|(
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8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit
19/19
EGF@E"1>:1 Kh|gq U~g`| :0
\CJHO PMW
Jeohm{iglkgbgh|u4
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