susceptibility towards formaldehyde-induced genotoxicity by günter speit

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  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    1/19

    EGF@E"1>:1 Kh|gq U~g`| :

    Uwueg~|`a`i`|p |m{jqlu fmqbjilgcplg"`hlwegl kghm|ms`e`|p

    Kh|gq U~g`|

    Wh`vgqu`|| Wib

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  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    2/19

    EGF@E"1>:1 Kh|gq U~g`| 1

    Uwueg~|`a`i`|p |m{jqlu fmqbjilgcplg"`hlwegl kghm|ms`e`|p

    Mw|i`hg mf |cg ~qgugh|j|`mh4

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    @@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p

    @@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u

    @V( ^mipbmq~c`ubu h |cg FLC kghg jhl uwueg~|`a`i`|p

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  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    3/19

    EGF@E"1>:1 Kh|gq U~g`| 5

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    {`|c ~qgl`u~mu`|`mh |m kqgj|gq qgu~mhug |m jh gs~muwqg4

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  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    4/19

    EGF@E"1>:1 Kh|gq U~g`| >3)4

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    |m `hlweg ejhegq `h |cg w~~gq qgu~`qj|mqp |qje|(

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  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    5/19

    EGF@E"1>:1 Kh|gq U~g`| 7

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  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    6/19

    EGF@E"1>:1 Kh|gq U~g`| 6

    @@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p

    U|wlp lgu`kh4

  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    7/19

    EGF@E"1>:1 Kh|gq U~g`| ;

    @@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p

    Aimml ujb~igu {gqg gs~mugl |m FJ `h v`|qm4

    Embg| juujp {ju ~gqfmqbgl |m bgjuwqg" FJ"`hlwegl LHJ ljbjkg #L^S)

    " qgbmvji #qg~j`q) mf FJ"`hlwegl L^S

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    " FJ"`hlwegl kghm|ms`e`|p #UEG)

  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    8/19

    EGF@E"1>:1 Kh|gq U~g`| 3

    @@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p

    Qguwi|u4

    Ijqkg l`ffgqghegu `h EM1"ughu`|`v`|p #hjuji `qq`|j|`mh)

    Hm u`kh`f`ejh| l`ffgqghegu ag|{ggh |cg uwakqmw~u

    " {`|c qgkjql |m |cg `hlwe|`mh mf kghm|ms`e gffge|u #L^S UEG)

    " {`|c qgkjql |m |cg ~qm|ge|`mh jkj`hu| FJ #FLC? L^S"qg~j`q)

    Tgiigq g| ji( Bw|j|( Qgu( ;15 ::":; #1>::)

  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    9/19

    EGF@E"1>:1 Kh|gq U~g`| 0

    @@( Hjuji ughu`|`v`|p jhl uwueg~|`a`i`|p |m{jqlu kghm|ms`e`|p

    Emqqgij|`mh jhjipu`u fmq jii ~jqjbg|gqu |gu|gl4

    " fmq jii uwadge|u

    " fmq |cg uwakqmw~u mf cp~gqughu`|`vg jhl cp~mughu`|`vg uwadge|u

    " fmq |cg uwakqmw~u mf gs|qgbip cp~gqughu`|`vg jhl cp~mughu`|`vg uwadge|u(

    Qguwi|u4

    Hm emqqgij|`mh ag|{ggh EM1"ughu`|`v`|p jhl |cg gs~qguu`mh mf FLC(

    Hm emqqgij|`mh ag|{ggh EM1"ughu`|`v`|p jhl `hl`ej|mqu mf egiiwijq ughu`|`v`|p(

    Hm uwakqmw~ {`|c ~jq|`ewijq bw|jkgh ughu`|`v`|p|m{jqlu FJ {ju `lgh|`f`gl(

    Tgiigq g| ji( Bw|j|( Qgu( ;15 ::":; #1>::)

  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    10/19

    EGF@E"1>:1 Kh|gq U~g`| :>

    @@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u

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    " `h 5> bjig ubmogqu

    " `h 5> fgbjig hmh"ubmogqu

    " `h 5> uecmmi ec`ilqgh

    \cg embg| juujp jhl |cg UEG"|gu| {gqg ~gqfmqbgl

    `h jeemqljheg {`|c |cg ~qgv`mwu u|wlp(

    \cg gs~qguu`mh mf |cg FLC"kghg {ju bgjuwqgl

    ap zwjh|`|j|`vg qgji"|`bg Q\"^EQ(

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  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    11/19

    EGF@E"1>:1 Kh|gq U~g`| ::

    @@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u

    Hm a`mimk`ejiip qgigvjh| l`ffgqghegu ag|{ggh |cg |cqgg kqmw~u(

  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    12/19

    EGF@E"1>:1 Kh|gq U~g`| :1

    @@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u

    LHJ ljbjkg

    LHJ qg~j`q

    UEG"|gu|

    FLC

  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    13/19

    EGF@E"1>:1 Kh|gq U~g`| :5

    @@@( ^m|gh|`ji uwueg~|`a`i`|p mf l`ffgqgh| u|wlp kqmw~u

    @hlwegl kghm|ms`e gffge|u #embg| juujp) jqg hm| juume`j|gl

    {`|c ~mipbmq~c`ubu `h KU\B: jhl KU\\:(

  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    14/19

    EGF@E"1>:1 Kh|gq U~g`| ::1 Kh|gq U~g`| :6

    @V( ^mipbmq~c`ubu `h |cg FLC kghg jhl uwueg~|`a`i`|p

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    mh kghg gs~qguu`mh #HEA@ lj|jajug)(

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  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    17/19

    EGF@E"1>:1 Kh|gq U~g`| :;

    @V( ^mipbmq~c`ubu `h |cg FLC kghg jhl uwueg~|`a`i`|p

    \cg vjq`jh| jiigig l`l hm| ejwug j l`ffgqgheg

    `h FLC gs~qguu`mh #bQHJ igvgi)(

    \cg vjq`jh| jiigig l`l hm| ejwug j l`ffgqgheg

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    " Hm l`ffgqgheg `h ajeokqmwhl LHJ gffge|u

    " Hm l`ffgqgheg `h FJ"`hlwegl L^S

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  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    18/19

    EGF@E"1>:1 Kh|gq U~g`| :3

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    {c`ec hggl |m ag emhu`lgqgl `h q`uo juuguubgh|(

  • 8/2/2019 Susceptibility Towards Formaldehyde-Induced Genotoxicity by Gnter Speit

    19/19

    EGF@E"1>:1 Kh|gq U~g`| :0

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