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Sponsored by AAGL Advancing Minimally Invasive Gynecology Worldwide Surgical Tutorial 3: Anatomy with Nerve Sparing PROGRAM CHAIR Robert M. Rogers, MD Sven Becker, MD, PhD Nucelio Lemos, MD, PhD Benoit Rabischong, MD, PhD

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Page 1: Surgical Tutorial 3: Anatomy with Nerve Sparing · 2020-01-30 · ureteral and pelvic nerves anatomy… Could be divided from a surgical point of view in 2 parts Right Ureter Vagina

Sponsored by

AAGLAdvancing Minimally Invasive Gynecology Worldwide

Surgical Tutorial 3: Anatomy with Nerve Sparing

PROGRAM CHAIR

Robert M. Rogers, MD

Sven Becker, MD, PhD Nucelio Lemos, MD, PhD Benoit Rabischong, MD, PhD

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Professional Education Information   Target Audience This educational activity is developed to meet the needs of residents, fellows and new minimally invasive specialists in the field of gynecology.  Accreditation AAGL is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.  The AAGL designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.   DISCLOSURE OF RELEVANT FINANCIAL RELATIONSHIPS As  a  provider  accredited  by  the Accreditation  Council  for  Continuing Medical  Education, AAGL must ensure balance, independence, and objectivity in all CME activities to promote improvements in health care and not proprietary interests of a commercial interest. The provider controls all decisions related to identification  of  CME  needs,  determination  of  educational  objectives,  selection  and  presentation  of content,  selection  of  all  persons  and  organizations  that will  be  in  a  position  to  control  the  content, selection  of  educational methods,  and  evaluation  of  the  activity.  Course  chairs,  planning  committee members,  presenters,  authors, moderators,  panel members,  and  others  in  a  position  to  control  the content of this activity are required to disclose relevant financial relationships with commercial interests related  to  the subject matter of  this educational activity. Learners are able  to assess  the potential  for commercial  bias  in  information  when  complete  disclosure,  resolution  of  conflicts  of  interest,  and acknowledgment of  commercial  support are provided prior  to  the activity.  Informed  learners are  the final safeguards in assuring that a CME activity is independent from commercial support. We believe this mechanism contributes to the transparency and accountability of CME.   

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Table of Contents 

 Course Description ........................................................................................................................................ 1  Disclosure ...................................................................................................................................................... 2  Visceral Innervation from the Promontory to the Vesicouterine Ligament with  Clinical Perspectives B. Rabischong  ............................................................................................................................................... 3  The Function and Purpose of the Visceral Nerves N. Lemos  ..................................................................................................................................................... 12  The End of Nerve‐Sparing Radical Hysterectomy? S. Becker  ..................................................................................................................................................... 15  Cultural and Linguistics Competency  ......................................................................................................... 20  

 

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Surgical  Tutorial  3:  Anatomy  with  Nerve  Sparing    

Robert  M.  Rogers,  Chair    

Faculty:  Sven  Becker,  Nucelio  Lemos,  Benoit  Rabischong    This   session   provides   participants   with   practical   instruction   on   the   anatomic   location   of   the   visceral  nerves   in   the   female   pelvis,   their   importance   to   the   patient   and   the   clinician,   and   surgical   dissection  techniques   for   exposing   these   fine   nerves.     Presentations   and   discussions   will   include   the   clinical  opinions   of  what   to   do  with   these   visceral   nerves   during   procedures   for   treatment   of   endometriosis,  chronic  pelvic  pain  and  gynecologic  cancers.    Learning  Objectives:  At  the  conclusion  of  this  course,  the  clinician  will  be  able  to:  1)  Explain  the  anatomic  location  of  the  visceral  nerves  in  the  pelvic  sidewall  and  demonstrate  the  surgical  dissection  techniques  needed  to  expose  these  fine  nerves.    

Course  Outline    2:15   Welcome,  Introductions  and  Course  Overview   R.M.  Rogers  

2:20   Visceral  Innervation  from  the  Promontory  to  the  Vesicouterine    Ligament  with  Clinical  Perspectives   B.  Rabischong  

2:35   The  Function  and  Purpose  of  the  Visceral  Nerves   N.  Lemos  

2:50   The  End  of  Nerve-­‐Sparing  Radical  Hysterectomy?   S.  Becker  

3:05   Questions  &  Answers   All  Faculty  

3:15   Adjourn  

1

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PLANNER  DISCLOSURE  The  following  members  of  AAGL  have  been  involved  in  the  educational  planning  of  this  workshop  and  have  no  conflict  of  interest  to  disclose  (in  alphabetical  order  by  last  name).  Art  Arellano,  Professional  Education  Manager,  AAGL*  Amber  Bradshaw  Speakers  Bureau:  Myriad  Genetics  Lab  Other:  Proctor:  Intuitive  Surgical  Erica  Dun*  Frank  D.  Loffer,  Medical  Director,  AAGL*  Linda  Michels,  Executive  Director,  AAGL*  Johnny  Yi*    SCIENTIFIC  PROGRAM  COMMITTEE  Arnold  P.  Advincula  Consultant:  Intuitive  Royalty:  CooperSurgical  Sarah  L.  Cohen*  Jon  I.  Einarsson*  Stuart  Hart  Consultant:  Covidien  Speakers  Bureau:  Boston  Scientific,  Covidien  Kimberly  A.  Kho  Contracted/Research:  Applied  Medical  Other:  Pivotal  Protocol  Advisor:  Actamax  Matthew  T.  Siedhoff  Other:  Payment  for  Training  Sales  Representatives:  Teleflex  M.  Jonathon  Solnik  Consultant:  Z  Microsystems  Other:  Faculty  for  PACE  Surgical  Courses:  Covidien    FACULTY  DISCLOSURE  The  following  have  agreed  to  provide  verbal  disclosure  of  their  relationships  prior  to  their  presentations.  They  have  also  agreed  to  support  their  presentations  and  clinical  recommendations  with  the  “best  available  evidence”  from  medical  literature  (in  alphabetical  order  by  last  name).  Sven  Becker*  Nucelio  Lemos  Speakers  Bureau:  Medtronic  Other:  Travel  Grants:  Medtronic  Other:  Researcher  Initiated  Support:  Laborie  Inc.,  Medtronic  Benoit  Rabischong*  Robert  M.  Rogers*        Asterisk  (*)  denotes  no  financial  relationships  to  disclose.  

2

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Visceral Innervationfrom the Promontory to Vesicouterine Ligaments

withClinical Perspectives

44th AAGL Global Congress, Las Vegas, Nevada 2015

B. Rabischong M.D

I have no financial relationships to disclose

Objective

• Discuss Visceral Innervation from Promontory to Vesicouterine Ligaments

Anatomy of Pelvic Visceral InnervationAn incomparable truncular neural network throughout the body…

1st part: Autonomic NervesHypogastric,

Splanchnic,

Inferior Hypogastric Plexus,

Visceral branches…

Anatomical Advantage of Laparoscopy

2nd part: Clinical applications

and Perspectives…

Topographic AnatomyRetroperitoneum:focus of the modern pelvic surgery

Septa and Spaces: accolaged visceral surface

Septa: vesico-vaginal, recto-vaginalSpaces: Retzius, paravesical, pararectal, retrorectal, presacral

Visceral ligaments: containing vessels/nerves

Sagitals: pubo-vesical, vesico-uterine, utero-sacralLaterals: parametrium, paracervix, lateral vesical et rectal

Visceral and parietal Fascia

Complex architecture based on connective tissue with 3 different degrees of density

Remarkable Interconnection of connective tissue

Crossed by: ureter, vessels, lymph nodes, somatic and autonomicnerves

P. Kamina

Topographic AnatomyLateral Spaces

Remarkable Interconnection of connective tissue

Ureter

Umbilicalartery

Uterine vessels

Obturator nerve

Vaginal vessels

PRFPVF

3

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Pelvic InnervationAutonomic Nerves, Pararectal Fossa

P. Kamina

Pararectal Spacedescribed by Japanese authors in radical hysterectomy

Could be divided in three spaces:

Latzko space (B)

Okabayashi space (C)

Yabuki or the Fourth space (D)« Paravaginal and pararectal space »

Yabuki et Al. Gynecol Oncol 2000

Pararectal Fossa (B,C,D)Latzko Space,right side

Ureter

Uterine ArteryUmbilical Artery

Pelvic Autonomic InnervationPararectal fossa, Visceral ligaments

Sympathetic system– Superior hypogastric plexus– Hypogastric nerves

Paraympathetic system Pelvic splanchnic nerves

Inferior hypogastric plexus

Visceral nerve branchesYamaguchi K. Clin Anat 2011

Pararectal fossaright hypogastric nerve(s) by Latzko space

Pay Attention to Operative Peritoneum!!!Hypogastric Nerve, right side

4

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Operative PeritoneumHypogastric Nerve, right side

Rectum

Douglas

Promontoire

Uretère Dt

Nerf Hypogastrique

Identification of Autonomic InnervationHypogastric Nerve

Rectum

Promontory

Right Ureter

Hypogastric Nerve

Identification of Autonomic InnervationHypogastric Nerve, Right Side

Douglas

Rectum

Ureter

Hypogastric Nerve

USL

Identification of Autonomic InnervationHypogastric Nerve, Left Side

Hypogastric NervePromontory

Splanchnic Nervesright pararectal fossa (Latzko)

5

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Inferior Hypogastric Plexus

Form of triangular blade (3 edges, 3 angles)

Constitution:• Hypogastric nerve, cranially

• Sacral sympathetic nerves, posteriorly

• Pelvic splanchnic nerves, caudally

Sagital direction

Relationships, Location:• Ureter, cranially

• Pelvic floor, caudally

• Rectum, medially

• Paracervix, Ligament latéral du rectum

• Landmark of Deep Uterine Vein

Ercoli A, Delmas V et Al. Surg Radiol Anat 2003Mauroy B, Bizet B et Al. Surg Radiol Anat 2007

Rectum Uretère

Middle Rectal Vessels

Inferior Hypogastric

Plexus

Inferior Hypogastric PlexusVisceral Branches in women

3 groups of visceral branches (fiber bundle or trunk)

• AnteriorVaginal, Vesical (vesical nerve),

• CranialUtero-vaginal (satellite of uterine artery), Superior Rectal

• Medial and inferiorInferior rectal

Vesical efferences (anterior and lateral)

• Paracervix, postero-lateral to vagina, vesicouterine ligament, uretero-vesical junction, bladder wall lat. and medial

• Satellite of ureter, outside and below

Ercoli A, Delmas V et Al. Surg Radiol Anat 2003Mauroy B, Bizet B et Al. Surg Radiol Anat 2007

The Vesicouterine LigamentAnatomicaly very fashionable now…

1st part: Superficial layer or Anterior leaf

Anterior and medial to the ureter

The « daily pillar of the bladder »

2nd part: Deep layer or Posterior leaf

Posterior and lateral to the ureter

Contains autonomic innervation / bladder

The focus of « distal » nerve sparing

In radical surgery, the surgeon should deal with:ureteral and pelvic nerves anatomy…

Could be divided from a surgical point of view in 2 parts

Right Ureter

Vagina

Bladder

Uterine Artery

VesicouterineLigament

Right Paravesical Space

Proximal Parametrium

VUL Radical Hysterectomy

12

Yabuki Spacethe fourth space, right side

Right Side

Vagina

Uterine Artery Ureter

Bladder Superficial Layer of Vesicouterine

Ligament

Parametrium

Umbilical and Superior Vesical

Arteries

Yabuki Space, Pelvic ureterRetroligamentory (U1), intraligamentory (U2), retrovesical (U3)

Left Side

Vagina

U1

U2

U3Uterine Artery

Uterus

Bladder

6

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Bladder

Vagina

Uterine Artery

AutonomicInnervation for bladder

Radical HysterectomyRight Side

Inferior Hypogastric PlexusVisceral Branches in women

3 groups of visceral branches (fiber bundle or trunk)

• Two AnteriorsVaginal, Vesical (vesical nerve),

Utero-vaginal (satellite of uterine artery), Superior Rectal Nerve

• Medial and inferior, inferior edge of IHPInferior rectal plexus or nerve

Rectal efferences (anterior and inferior)

• Superior rectal nerve / Recto-vaginal space/ Superior part and anterior wall of rectum

• Inferior rectal plexus / inferior part of rectum and IAS

• +/- Branches satelite of middle rectal artery

Ercoli A, Delmas V et Al. Surg Radiol Anat 2003Mauroy B, Bizet B et Al. Surg Radiol Anat 2007

Inferior Hypogastric PlexusVisceral Branches in women

3 groups of visceral branches (fiber bundle or trunk)

• Two AnteriorsVaginal, Vesical (vesical nerve),

Utero-vaginal (satellite of uterine artery), Superior Rectal Nerve

• Medial and inferior, inferior edge of IHPInferior rectal plexus or nerve

Rectal efferences (anterior and inferior)

• Superior rectal nerve / Recto-vaginal space/ Superior part and anterior wall of rectum

• Inferior rectal plexus / inferior part of rectum and IAS

• +/- Branches satelite of middle rectal artery

Ercoli A, Delmas V et Al. Surg Radiol Anat 2003Mauroy B, Bizet B et Al. Surg Radiol Anat 2007

Superior rectal plexus

Inferior rectal plexus

Rectovaginal SeptumPosterior Mesh, Genital Prolapse

Pelvic Autonomic InnervationBladder and sexual functions

Sympathetic system / Adrenergic• Compliance and storage• Stimulation of urethral smooth sphincter• Inhibition of detrusor muscle

Paraympathetic system / Cholinergic

• Voiding• Stimulation of detrusor• Inhibition of urethral smooth sphincter• Vaginal lubrification and genital swelling

Yoshimura et al. Korean J Urol 2014

What happens if I cut ?Bladder and sexual functions

Superior hypogastric plexus and hypogastric nerves• Urinary incontinence• Urgency

Pelvic splanchnic nerves• Bladder atonia• Disorders of bladder sensitivity• Decreasing blood flow to vagina, lubrification

IHP and visceral branches• Various dysfunctions according to the level of injury

The chance of the surgeon:• Consequences seem to be more limited if unilateral injury

But is it always so simple in the real life ? Probably No...

7

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NO because...Coexistence of adrenergic and cholinergic fibers in sympathetic and parasympathetic

« Computer assisted dissection » (CADD)3D reconstruction with immuohistochemical techniques

Descriptive and functional anatomical study

Alsaid B et Al. J Anat 2009

No because... Anatomical variationsMen-Women Differences, Hypogastric nerves

Yamaguchi K et Al. Clin Anat 2011

No because...Anatomical variationsMen-Women Differences, Hypogastric nerves

Yamaguchi K et Al. Clin Anat 2011

Clinical Applications, « Nerve Sparing », from Dr. Okabayashi until now...Evolution in the concept

• Kobayashi 1961, Tokyo method (laparotomy)

• Sakamoto 1980 (laparotomy)

• Hoeckel 1998 (laparotomy)

• Possover 1999 (laparoscopy)

• Maas, Trimbos 2000 (laparotomy)

• Kuwabara 2000 (laparotomy)

• Kato, Murakami, Yabuki 2000-2003 (laparo)

• Querleu 2002 (coelio-vaginale)• Ercoli, Delmas 2003 (cadaver)• Raspagliesi 2004 (laparotomy)

• Sakuragi 2005 (laparotomy)

• Possover 2005, LANN technique• Fujii 2008 (laparotomy)• ………..

Old Japanese Concept Objective: decrease urinary morbidity with same radicality

Sakuragi N. Int J Gynecol Cancer 2005

Parametrium, paracervix, ureter,Deep uterine vein

Left Side

Uterine Artery

UmbilicalArtery

Parametrium

Paracervix

« Nerve Sparing » from Okabayashi until now...Radical Hysterectomy, paracervix resection

Technical principles of lymphadenectomy

8

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Excision of parametrium and paracervixleft side

Obturator nerve

Pectineus ligament

EIV

Vaginal vessels

Obturator muscle

Ilio-coccygeus

PRF

Nerve Sparing in Endometriosis...Left Hypogastric Nerve

Ureter

Hypogastric Nerve

Nodule

Nerve Sparing in Endometriosis...Left Hypogastric Nerve, final view

U

EndometriosisNegra Method

Ceccarioni M. Surg Endosc 2012

Functional Results in DIEIs it effective? prospective study

Ceccaroni M et Al. Surg Endosc 2012

PerspectivesTo a better understanding of the nervous control

« Computer assisted dissection » (CADD)3D reconstruction with immuohistochemical techniques

Descriptive and functional anatomical study

Moszkovicz et Al. Surg Radiol Anat 2011

9

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PerspectivesPeroperative Neurostimulation Katahira A et Al. Gynecol oncol 2005

Possover M et Al. J Am Coll Surg 2005

Kneist W et Al. Eur Surg Res 2011

For the FuturLaparoscopic implantation of neural electrode

Restoring of motor or autonomic functions

Functional electrostimulation

Clinical perspectives ++:Paraplegic, bladder and rectal dysfunction, pelvic chronic pain

Possover et Al. New strategies of pelvic nerves stimulation for recovery of pelvicvisceral functions and locomtion in paraplegics. Neurourol Urodynam 2010.

Rabischong et Al. Laparoscopic implantation of neural electrodes on pelvic nerves:an experimental study on the obturator nerve in a chronic minipig model. SurgEndosc 2011

Clinical ApplicationNew strategies of pelvic nerves stimulation for recovery of pelvic visceral functions and locomtion in paraplegicsM. Possover et Al. Neurourol Urodynam 2010

Three patients with spinal cord injuries (Th5, Th7, Th10)

Bilateral laparoscopic implantation of:

octipolar elctrodes on sciatic and pudendal nerves

Brindley-Finetech extradural double elctrode on S3 and S4 roots

Brindley-Finetech sinlge elctrodes on femoral nerves

Results

Control of spasticity of lower extremities and of reflex incontinence by

stimulation of sciatic and pudendal nerves

Bladder emptying by sacral roots stimultion +/- interruption of pudendal

stimulation +/- pudendal nerve inhibition with high-frequency current

Standing and pendular walking by femoral stimulation in 2 patients

PerspectivesBeyond Nerve Sparing...

Rabischong B et Al. Surg Endosc 2011

PerspectivesBeyond Nerve Sparing...

Rabischong B et Al. Surg Endosc 2011

ConclusionsWe are still far from knowing everything...

Architectural and functional complexity of pelvic nervous system

Minimum theoretical knowledge is now essential

"Anatomical" advantage of laparoscopic approach satisfying the requirements of the modern pelvic surgery

Optimization of nerve preservation by new techniques of electrostimulation or virtual imaging or augmented reality

Beyond nerve sparing… fascinating clinicalperspectives…Neuropelveology

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Thank You Very Much For Your Attention !

http://theison.org/

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The Function and Purpose of the Visceral Nerves 

NUCELIO LEMOS

FEDERAL UNIVERSITY OF SÃO PAULODEPARTMENT OF GYNECOLOGY

PELVIC NEURODYSFUNCTION CLINIC

• Speakers Bureau: Medtronic• Other: Travel Grants: Medtronic• Other: Researcher: Initiated Support: Laborie Inc., Medtronic

• Review the main anatomical aspects of pelvicfloor neuro‐physiology

• Discuss the neural pathways behind pelvicfloor function

Continence

Petros & Ulmsten, 1993

LongitudinalMuscle

Of the Anus

LevatorPlate

“Hammock”

Post = AntR = 0

LUT Function

Petros & Ulmsten, 1

Micturition

LongitudinalMuscle

Of the Anus

LevatorPlate

“Hammock”

Post > AntR > 0

Petros & Ulmsten, 1993

12

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Anal Continence

Adapted from Rogers, RM.

MIC

RECTOVAGINAL FASCIA ANDPOST. RECTAL

WALLTRACTION: LEVATOR

PLATE

RECTOVAGINALFASCIA

COUNTERTRACTION: PERINEAL

BODY

RECTALANGULATION: PUBORECTALI

S MUSCLE

ANAL CANALSHORTENING:

LONGINTUDINALMUSCLE OF TH ANUS

Petros&Swash, 20

Bowel Emptying

ICM

RECTOVAGINAL FASCIA ANDPOST. RECTAL

WALLTRACTION: LEVATOR

PLATE

RECTOVAGINAL FASCIA

COUNTERTRACTION:

PERINEALBODY

RECTALANGULATION: PUBORECTALI

S MUSCLE

Petros&Swash, 2

Autonomic Nerves

9

Hypogastric Nerves(sympathetic)

Proprioception (filling sensation)nternal urethral and anal sphincters

up. Hypogastric Plexus(derived from sympathetic trunk)

Pelvic Splanchnic Nerves(nervi erigenti)Detrusor contractionCólon descendens, sigmoid and rectumNociception

Inf. Hypogastric Plexus

Image from

Hypogastric Nerve

Autonomic Nerves

11Image fro

Hypogastric Nerves(sympathetic)

Proprioception (filling sensation)ernal urethral and anal sphincters

p. Hypogastric Plexus(derived from sympathetic trunk)

Pelvic Splanchnic Nerves(nervi erigenti)Detrusor contractionCólon descendens, sigmoid and rectumNociception

Inf. Hypogastric Plexus

The Sacral Nerve Roots

13

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Neurophysiology of the LUT

Th10-L2 - Sympathetic- Internal Urethral Sphincter Contraction (α1)

- Detrusor Relaxation (β)

S2-S4 - Parasympathetic (M3)- Detrusor Contraction- Internal Urethral Sphincter Relaxation

S2-S4 - Somatic Nervous System- Urethral Contraction- Levator Ani Muscle Contraction

L1

L2

S2

S3

S4

M3

[email protected]

www.neurodisfuncao.med.br

[email protected]

www.neurodisfuncao.med.br

• Neurology of Sexual and Bladder Disorders: Handbook of Clinical Neurology, 3rd Series. Elsevier. Amsterdam, 2015.

• Possover M, Chiantera V, Baekelandt J. Anatomy of the Sacral Roots and the Pelvic Splanchnic Nerves in Women Using the LANN Technique. Surg Laparosc Endosc Percutan Tech. 2007 Dec;17(6):508‐10.

• Possover, Rhiem, Chiantera. The "Laparoscopic Neuro‐Navigation" ‐‐ LANN: from a functional cartography of the pelvic autonomous neurosystem to a new field of laparoscopic surgery. Minim Invasive Ther Allied Technol. 2004 Dec;13(5):362‐7.

• Possover M, Quakernack J, Chiantera V. The LANN technique to reduce postoperative functional morbidity in laparoscopic radical pelvic surgery. J Am Coll Surg. 2005 Dec;201(6):913‐7. Epub 2005 Oct 10. 

• Lemos N, Souza C, Marques RM, Kamergorodsky G, Schor E, Girão MJ. Laparoscopic anatomy of the autonomic nerves of the pelvis and the concept of nerve‐sparing surgery by direct visualization of autonomic nerve bundles. Fertil Steril. 2015. doi: 10.1016/j.fertnstert.2015.07.1138.

• Lemos N, Possover M. Laparoscopic Approach to Intrapelvic Nerve Entrapments. J Hip Preserv Surgery 2015; 2(2)92‐98.

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The End of Nerve-Sparing Radical Hysterectomy

Sven Becker

Frankfurt University Women’s Hospital

I have no financial relationships to disclose.

Discuss the following statement:

While Nerve-Sparing Radical Hysterectoy is aninteresting technical concept, it does not fitwith current oncologic understanding ofcervical cancer treatment

Four Main Points

• 1. Cervical Cancer with extensive parametrial involvement and node-positive Cervical Cancer should be treated with primary radiation

• 2. Early Stage – node negative cervical cancer can be operated on with minimal parametrial resection

• 3. Extensive Parametrial resection does not fit into our modern concept of cervical cancer treatment

• 4. Without extensive parametrial resection, nerve-sparing techniques are unnecessary

Four Main Points

• 1. Cervical Cancer with extensive parametrial involvement and node-positive Cervical Cancer should be treated with primary radiation

Lancet, 1997

The Study that‘s the Elephant in the Room

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Lancet, 1997 Lancet, 1997

Indications for Adjuvant Radiochemotherapy

- Positive Lymphnodes- Tumor-Size > 4 cm- (Extensive) Parametrial Infiltration- Positive Margins- Inadequate Lymphonodectomy (< 15 pelvic nodes)- L1, V1

German Recommendations

Querleu – Morrow- Classification

A – Minimal Resection of Paracervical TissueDissection/Visualization of Ureters without MobilisationGoal: Complete Removal of Cervix

Early Cervical Cancer < 2 cmWithout nodal InvolvementWithout LVS+

Hysterectomy after Radiation

Querleu – Morrow- Klassifikation

B – Ureter-Tunnel dissected – Ureter Lateralized+ paracervical LND instead of total lateral resection (B2)

Paracervical LND = medial of N. obturatoriusIliacal LND = lateral of N. obturatorius

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Querleu – Morrow- Classification

C – Complete Mobilization of UreterResection of Uterosacrale Ligament near RectumResection of Vesicouterine Ligament near Bladder

C1 nerve-sparingC2 not nerve-sparing

Nerve-sparing WITHOUT subsequent Radiation…?

Four Main Points

• 2. Early Stage – node negative cervical cancer can be operated on with minimal parametrial resection

125 Pat. IB1-IIA 62 Typ I --- 63 Typ III Radical Hysterectomy

Morbidity 45% --- 85%

15 J. Survival 76% vs. 80% for Tumors < 3 cm

2011

Minimal Risk of Parametrial Invasion:< 2 cm Size< 1 cm Invasion

2011

Oncologic Tailoring instead of unnecessary parametrial resection with nerve-sparing approach?

Negative Sentinel-Node simple Hysterektomie60 Pat.Median Follow-Up 47 MonthsNo Recurrences

2009

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GOG-Studie (USA)Shape-Trial (Kanada, GCIG)

2013

SHAPE-TRIAL

Gynecologic Oncology 2013

Selecting the right Patient!

Four Main Points

• 3. Extensive Parametrial resection does not fit into our modern concept of cervical cancer treatment

• 4. Without extensive parametrial resection, nerve-sparing techniques are unnecessary

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Is Landoni right?Is Surgery plus Radiochemotherapy really inacceptable?

Could radical laparoscopy and nerve-sparing-surgery PLUS adjuvant radiochemotherapy yield different morbidities?

The big, unanswered question:

2009

2009

2012

2012Summary

• 1. Cervical Cancer with extensive parametrial involvement and node-positive Cervical Cancer should be treated with primary radiation

• 2. Early Stage – node negative cervical cancer can be operated on with minimal parametrial resection

• 3. Extensive Parametrial resection does not fit into our modern concept of cervical cancer treatment

• 4. Without extensive parametrial resection, nerve-sparing techniques are unnecessary

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CULTURAL AND LINGUISTIC COMPETENCY Governor Arnold Schwarzenegger signed into law AB 1195 (eff. 7/1/06) requiring local CME providers, such as

the AAGL, to assist in enhancing the cultural and linguistic competency of California’s physicians

(researchers and doctors without patient contact are exempt). This mandate follows the federal Civil Rights Act of 1964, Executive Order 13166 (2000) and the Dymally-Alatorre Bilingual Services Act (1973), all of which

recognize, as confirmed by the US Census Bureau, that substantial numbers of patients possess limited English proficiency (LEP).

California Business & Professions Code §2190.1(c)(3) requires a review and explanation of the laws

identified above so as to fulfill AAGL’s obligations pursuant to California law. Additional guidance is provided by the Institute for Medical Quality at http://www.imq.org

Title VI of the Civil Rights Act of 1964 prohibits recipients of federal financial assistance from

discriminating against or otherwise excluding individuals on the basis of race, color, or national origin in any of their activities. In 1974, the US Supreme Court recognized LEP individuals as potential victims of national

origin discrimination. In all situations, federal agencies are required to assess the number or proportion of LEP individuals in the eligible service population, the frequency with which they come into contact with the

program, the importance of the services, and the resources available to the recipient, including the mix of oral

and written language services. Additional details may be found in the Department of Justice Policy Guidance Document: Enforcement of Title VI of the Civil Rights Act of 1964 http://www.usdoj.gov/crt/cor/pubs.htm.

Executive Order 13166,”Improving Access to Services for Persons with Limited English

Proficiency”, signed by the President on August 11, 2000 http://www.usdoj.gov/crt/cor/13166.htm was the genesis of the Guidance Document mentioned above. The Executive Order requires all federal agencies,

including those which provide federal financial assistance, to examine the services they provide, identify any

need for services to LEP individuals, and develop and implement a system to provide those services so LEP persons can have meaningful access.

Dymally-Alatorre Bilingual Services Act (California Government Code §7290 et seq.) requires every

California state agency which either provides information to, or has contact with, the public to provide bilingual

interpreters as well as translated materials explaining those services whenever the local agency serves LEP members of a group whose numbers exceed 5% of the general population.

~

If you add staff to assist with LEP patients, confirm their translation skills, not just their language skills.

A 2007 Northern California study from Sutter Health confirmed that being bilingual does not guarantee competence as a medical interpreter. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2078538.

US Population

Language Spoken at Home

English

Spanish

AsianOther

Indo-Euro

California

Language Spoken at Home

Spanish

English

OtherAsian

Indo-Euro

19.7% of the US Population speaks a language other than English at home In California, this number is 42.5%

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