surgical legacies of modern combat: translating
TRANSCRIPT
![Page 1: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/1.jpg)
© American College of Surgeons 2017. All rights reserved Worldwide.
Achieving Zero Preventable Deaths Conference
Apri l 18-19, 2017
B r ian East r idge , M D , F A C S
C O L, M C , U SA R
P rof e ssor o f Su rge ry
U n iv e r s i t y o f T e x as He a l t h San A n t on io
Surgical Legacies of Modern Combat:
Translating Battlefield Medical
Practices into Civilian Trauma Care
![Page 2: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/2.jpg)
The opinions or assertions contained herein
are the private views of the author and are
not to be construed as official or as
reflecting the views of the Department of the
Army or the Department of Defense.
Disclaimer
Disclosures
None
![Page 3: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/3.jpg)
War’s Role as a Teacher For Antiquity
“He who would become a surgeon should join an army and follow it for war is the only proper school for a surgeon’..”
![Page 4: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/4.jpg)
History of Battlefield Medical Lessons
World War I • IV fluids • Blood transfusions • Motorized ambulances • Topical antisepsis
World War II • Whole blood/plasma available • Specialty-specific surgical groups • Antibiotics • Fixed wing aero-medical evacuation
Korean Conflict • Improved fluid resuscitation • Forward availability of definitive
surgery • Helicopters for patient evac/transport • Primary repair/grafts for vascular injury
Vietnam • Improved use of helicopters • Improved laboratory support • Portable radiology equipment • Mechanical ventilators in theater
Desert Shield/Storm • Burn team augmentation of
evacuation hospitals to provide theater-wide burn care
• Intercontinental aeromedical transport of burn patients
![Page 5: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/5.jpg)
Contemporary Battlefield Lessons Learned Joint Trauma System
• Focused empiricism / timely dissemination of knowledge
• Performance Improvement / generation of best practices
• Epidemiology of injury death
• Tactical Combat Casualty Care
• Acute surgical care
• Damage control resuscitation
• Forward surgical elements
• Serial damage control surgery
![Page 6: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/6.jpg)
• Unorganized delivery of trauma care on the battlefield • Casualties going to the wrong location • Suboptimal staffing and placement of surgical assets
• Medical records are not reliably being delivered with casualties at each level (<40%) • Impact on clinical care • Documentation directive
• No trauma registry driven by medical input that allows accurate description of injuries or deaths • Unable to reliably answer questions and improve outcomes
• Survivable Injuries and/or deaths • Lack of performance improvement measures / research
Genesis of the Military Trauma System Effort
Review of Battlefield Medical Care
Army Trauma Consultant 2003
![Page 7: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/7.jpg)
© American College of Surgeons 2017. All rights reserved Worldwide.
Battlefield Lesson
Learning Healthcare System
![Page 8: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/8.jpg)
Joint Trauma System Operational Cycle
DATA ANALYSIS DOD
TRAUMA REGISTRY
TRAUMA CARE
DELIVERY
PERFORMANCE IMPROVEMENT
FIGURE 4-3 Joint Trauma System operational cycle and links to the U.S. Department of Defense’s Combat Casualty Care Research Program. NOTE: DoD = U.S. Department of Defense; PI = performance improvement. SOURCE: Haut et al., 2016.
![Page 9: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/9.jpg)
JTS Directorate
Functions and Services
Concurrent Reports
Clinical Practice Guidelines
Special Projects
Performance Improvement
Reports
![Page 10: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/10.jpg)
Clinical Practice Guidelines
• Evidence-based
• Best clinical practice
• Tailored to operational battlefield environment
• Open access
• Resource for deploying surgeons and medical providers
![Page 11: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/11.jpg)
Focused Epiricism
• Successes
– Damage control resuscitation
– Whole blood for massive transfusion
– Tranexamic acid
• Failures
– Factor VIIa
Pragmatic approach to process improvement
– Urgency to improve outcomes because of high morbidity and mortality rates
– High-quality data are not available to inform clinical practice changes
– Data collection is possible.
• Principle of focused empiricism is using the best data available in combination with clinical experience to develop clinical practice guidelines through an iterative process
![Page 12: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/12.jpg)
12
0
5
10
15
20
25
2003 2004 2005 2006 2007 2008 2009 2010
Avg
Nu
mb
er
of
Un
its
Year
Average Component Units per Massive Transfusion
PRBC
FFP
Whole Blood
Platelets
Deployment of 1st
JTTS trauma team Aug 2004
Official Massive Transfusion
CPG issued Dec 2004
![Page 13: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/13.jpg)
0.0%
10.0%
20.0%
30.0%
40.0%
50.0%
60.0%
70.0%
2003 2004 2005 2006 2007 2008 2009 2010
Crude Adherence Rate
Death Rate
13
IRAQ
AFGHANISTAN
Damage Control Resuscitation
Compliance
![Page 14: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/14.jpg)
© American College of Surgeons 2017. All rights reserved Worldwide.
Battlefield Lesson
Epidemiology
of
Prehospital Trauma Mortality
![Page 15: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/15.jpg)
DOW
KIA
![Page 16: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/16.jpg)
![Page 17: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/17.jpg)
Hemorrhage Focus (n=888)
67.3% n=598
19.2% n=171
13.5% n=119
Truncal
Junctional
Extremity
36% Thoracic (max AIS 3)
64% Abdominopelvic (max AIS 4/5)
39% Cervical (max AIS 1) 61% Axilla and Groin (max AIS 5)
![Page 18: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/18.jpg)
Eliminating Preventable Death
on the Battlefield • US Military
– Preventable Prehospital Deaths = 25% • US Rangers
– Preventable Deaths = 3%
• Ranger success attribution: – Leadership
• Command-directed casualty response program
– Training • All Rangers and Docs trained in TCCC
Kotwal RS, Montgomery HR, Kotwal BM, et al. Eliminating preventable death on the battlefield. Arch Surg 2011.
![Page 19: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/19.jpg)
Multi-Disciplinary Multi-Institutional Mortality Investigation in the Civilian
Prehospital Environment (MIMIC)
• Develop a methodology for evaluating the causes and pathophysiology of pre-hospital deaths (optimal & in context)
• Network of experts to apply the methodology to identify the causes of pre-hospital deaths due to trauma and estimate the potential for survivability. – Trauma surgery
– Neurosurgery
– Orthopedic surgery
– Forensic pathology
– Emergency medicine
– Emergency medical services
![Page 20: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/20.jpg)
• Define the causes and pathophysiologic mechanisms of 3,000 pre-hospital deaths occurring in six regions of the country representative of the population.
• Describe the epidemiology of pre-hospital mortality in the context of trauma system development and estimate human and fiscal impact on society.
• Develop a blueprint for a sustained public health / injury mitigation strategies in the pre-hospital environment, identifying high priority areas for trauma systems performance improvement
Multi-Disciplinary Multi-Institutional Mortality Investigation in the Civilian
Prehospital Environment (MIMIC)
![Page 21: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/21.jpg)
© American College of Surgeons 2017. All rights reserved Worldwide.
Battlefield Lesson
Pre-Hospital Care
![Page 22: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/22.jpg)
Tactical Combat Casualty Care
Tactical Combat Casualty Care Set of trauma management guidelines customized for the battlefield that focus on the most common causes of preventable deaths on the battlefield:
• Hemorrhage • Noncompressible • Junctional • Peripheral
• Airway obstruction • Tension pneumothorax
Butler FK, Hagmann J, Butler EG. Tactical combat casualty care in special operations. Military Medicine 1996;161(Suppl.):3-16.
![Page 23: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/23.jpg)
Pre-Hospital Translation of Lessons Learned
Tactical Combat Casualty Care Hartford Consensus
Threat suppression
Hemorrhage control
Rapid Extrication to safety
Assessment by medical providers
Transport to definitive care • Need integrated response
Fire, EMS, Law Enforcement, Medical
![Page 24: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/24.jpg)
The Hartford Consensus
24
• American College of Surgeons • FBI • White House – Medical Policy • White House Medical • Asst Secretary of Defense - Health Affairs • Asst Secretary of Homeland Security – Health Affairs • Medical Section – Major Chiefs of Police • ACS Committee on Trauma • DoD Committee on TCCC
Improving Survival from Active Shooter Events: The Hartford Consensus Active Shooter and Intentional Mass-Casualty Events: The Hartford Consensus II The Hartford Consensus III: Implementation of Bleeding Control The Hartford Consensus IV: A Call for Increased National Resilience
![Page 25: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/25.jpg)
Pre-Hospital Translation Initiatives
LEFR-TCC Law Enforcement First Responder Tactical Casualty Care NAEMT
![Page 26: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/26.jpg)
Hemorrhage Control: Tourniquets
Kragh, et al – Tourniquet Study
• Ibn Sina Hospital, Baghdad, 2006
• Tourniquets are saving lives on the battlefield
• 31 lives saved in 6 months by use of prehospital tourniquets
Kragh JF, Walters TJ, Baer DG, et al. Survival with emergency tourniquet use to stop bleeding in major limb trauma. Annals of Surgery, 2009. 249(1):1-7.
![Page 27: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/27.jpg)
0
5
10
15
20
25
Pre-Tourniquet(Pre2006)
Transi on(2006-2007) Post-Tourniquet(Post2007)
IsolatedExtremityDeaths/Year
TCCCInterven on
Impact of Tourniquets on the Battlefield
Eastridge et al: Death on the Battlefield: Implications for the Future of Combat Casualty Care. J Trauma 2012
![Page 28: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/28.jpg)
Civilian Tourniquet Consensus
• Data strongly suggests that tourniquet use saves lives.
• Adverse side effects associated with tourniquets appear to be manageable and do not appear to outweigh the benefits of tourniquet use.
![Page 29: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/29.jpg)
© American College of Surgeons 2017. All rights reserved Worldwide.
Battlefield Lesson
Resuscitation
![Page 30: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/30.jpg)
Hemostatic Resuscitation
![Page 31: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/31.jpg)
Civilian Trial Pragmatic Randomized Optimal Platelet
and Plasma Ratio Trial (PROPPR)
Holcomb et al JAMA 2015;313:471 – 482
![Page 32: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/32.jpg)
Whole Blood Resuscitation in Combat
Fresh whole blood use by forward surgical teams in Afghanistan
is associated with improved survival compared to component therapy without platelets
Transfusion 2013
Shawn C. Nessen, Brian J. Eastridge, Daniel Cronk, Robert M. Craig, Olle Berséus, Richard Ellison, Kyle Remick, Jason Seery, Avani Shah, and Philip C. Spinella
FWB in austere combat environments safe and independently associated with improved survival when compared with resuscitation with RBCs and FFP alone.
![Page 33: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/33.jpg)
Whole Blood: Back to the Future
• Whole blood historically primary resuscitative solution for hemorrhagic shock.
• Transition to using component therapy occurred without evidence superior efficacy or safety.
• Misconceptions
– Whole blood must be ABO specific (O low titer 1:256)
– Whole blood cannot be leukoreduced
– Cold storage causes loss of platelet function
• Cold whole blood stored for up to 21 days has greater hemostatic capacity than blood components transfused in a 1 : 1 : 1 (in vitro)
Spinella, Cap: Curr Opin Hematol 2016, 23
![Page 34: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/34.jpg)
© American College of Surgeons 2017. All rights reserved Worldwide.
Battlefield Lesson
Forward Transitioning
Damage Control Philosophy
![Page 35: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/35.jpg)
Pre-Hospital DCR Concepts
• Stop obvious hemorrhage
– Hemostatic adjuncts
• Correction of coagulopathy
• Judicious fluid management (permissive hypotension)
• Thermoregulation
• Minimize pre-hospital time (“Golden Hour” is relative)
![Page 36: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/36.jpg)
Golden Hour and the Gates Effect
![Page 37: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/37.jpg)
Prehospital Time Noncompressible Torso Hemorrhage (GSW)
Alarhayem, Eastridge, et al: Mortality in Trauma Patients with Hemorrhage from Torso Injury Occurs Long Before the “Golden Hour” Presented at Southwestern Surgical Congress April 2016
Alarhayem, Eastridge: Time is the Enemy. Am J Surg 2016
Critical nature of prehospital time in patients with non-compressible torso hemorrhage. Evacuation times < 30 minutes not realistic, particularly in rural or austere environments. Emphasizes need to develop therapies to increase the window of survival in the prehospital environment.
![Page 38: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/38.jpg)
Military Tactical DCR Forward
• FWB is the best prehospital resuscitation fluid
• 75th Ranger Regiment program – Type O – Low Titer
Anti-A, Anti-B abs – Donors pre-screened
for typing, titers, and infectious diseases
– Use donor pool to transfuse casualties in shock
![Page 39: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/39.jpg)
Civilian DCR Forward
![Page 40: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/40.jpg)
Prehospital Plasma PAMPer Trial
![Page 41: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/41.jpg)
Prehospital Blood Outcomes
![Page 42: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/42.jpg)
• Program development /proof of concept in process at several institutions
– Mayo Clinic
– University of Pittsburgh
– University of Texas Health San Antonio / San Antonio Military Medical Center
Prehospital Whole Blood
![Page 43: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/43.jpg)
DCR Forward
• Scoop and Run or Stay and Play?
• Advanced providers?
• Critical care capabilities
• Blood products
• Surgical capability enroute
Versus
![Page 44: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/44.jpg)
UK MERT
2.3 3.4
7 8.9
15.2
37.5
0
5
10
15
20
25
30
35
40
ISS 1-9 ISS 10-19 ISS > 20
Observed Mortality Expected Mortality
Apodaca et al: Performance improvement evaluation of forward aeromedical evacuation platforms in Operation Enduring Freedom. J Trauma Acute Care Surg. 2013
![Page 45: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/45.jpg)
Battlefield Continuum of Care
Proof of Concept Forward Surgery
BAS
Level 1
Forward Surgical
teams
Level 2 Combat Support
Hospital, EMEDS, Fleet
Hospital
Level 3 Definitive Care
Level 4
Route from Injury to Definitive Care
Surgical Capability
CASEVAC 1 Hour TACTICAL
EVAC 24 Hours
STRATEGIC EVAC 48-72 Hours
![Page 46: Surgical Legacies of Modern Combat: Translating](https://reader030.vdocuments.site/reader030/viewer/2022012505/617facf05285175a5943ff5c/html5/thumbnails/46.jpg)
Bidirectional