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C am ptothecin (nM ) 1 10 100 1000 % ofgrow th 0 20 40 60 80 100 120 Parental (IC 50 = 257.9nM ) Tam R 7 (IC 50 = 146.5nM ) Tam C 3 (IC 50 = 11.5nM ) Tam R 3 (IC 50 = 7.3nM ) Tam C 6 (IC 50 = 373.6nM ) Tam R 6 (IC 50 = 207.6nM ) M D A-M B-231 (IC 50 =590.9nM) SKBr3 (IC 50 = 25.9nM ) ppl. Fig. S3

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Page 1: Suppl. Fig. S3

Camptothecin (nM)

1 10 100 1000

% o

f g

row

th

0

20

40

60

80

100

120

Parental (IC50 = 257.9nM)

TamR7 (IC50 = 146.5nM)

TamC3 (IC50 = 11.5nM)

TamR3 (IC50 = 7.3nM)

TamC6 (IC50 = 373.6nM)

TamR6 (IC50 = 207.6nM)

MDA-MB-231 (IC50 =590.9nM)

SKBr3 (IC50 = 25.9nM)

Suppl. Fig. S3

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