sun & environment: get connected, get … · the ma-jor biologic effects of acute exposure to...

SUN & ENVIRONMENT: GET CONNECTED, GET PROTECTED

L ’ O R É A L R E S E A R C H & I N N O V A T I O N S Y M P O S I U M

The mission of the L’Oréal Group is to offer the best of beauty to all

women and men on the planet and Innovation has been a driving

force for L’Oréal growth. The diversity of hair and skin types and the

diversity of beauty needs are a vital part of the creative processes at

L’Oréal Research & Innovation.

Our commitment to better understanding skin and hair diversity can be

fully appreciated in technological advances in hair care and coloration

and in photoprotection.

Furthermore, L’Oréal Research endeavors to identify mechanisms of

skin sensitivity to the light, in particular to UVA light, in different parts

of the world. Thanks to “in vitro“ skin models, we have deciphered the

biological influences of UV light and of different environmental factors

on this particular tissue.

Today, given the diversity of skin types and the variations of environ-

mental conditions, a personalized monitoring of environmental risks is

indispensable. In relevant prevention strategies, new technologies, like

flexible sensors, are paving the way for individualized connected envi-

ronmental protection.

EDITORIAL

Michèle VERSCHOORE, MDMedical Director,

L’Oréal Research and Innovation,

S U N & E N V I R O N M E N T : G E T C O N N E C T E D , G E T P R O T E C T E D

5.00 PM Opening Remarks

Françoise BERNERD

5.05 PM Evolutionary Adaptation of the Skin to the Environment Mark SHRIVER

5.30 PM Effect of Sunlight and Pollution on the Skin Henry W. LIM

6.00 PM An Integrated Strategy Against Environmental Stress

Didier CANDAU

6.30 PM Stretchable Bioelectronics for Continuous Characterization and Monitoring of Skin Health Roozbeh GHAFFARI

6.55 PM Closing Remarks Mark SHRIVER

SUN & ENVIRONMENT: GET CONNECTED, GET PROTECTED

ChairmanMark SHRIVER, PhD

Associate Professor of Anthropologyand Genetics at Penn State University,

State College, USA

Co-ChairmanFrançoise BERNERD, PhDL’Oréal Research & Innovation Fellow, Head of Light and Pigmentation Research Group. Advanced Research, France

VANCOUVER CONVENTION CENTER: ROOM: WEST 118 - 120 TUESDAY, JUNE 9TH - 5PM - 7PM





There are many sources of information regarding the physiology and pathophysiology of the human skin and its responses to environmental exposures. Human evolution has provided a series of natural experiments as humans first spread across the natal continent Africa and then across the rest of the world. Although human populations can differ substantially in superficial traits such as skin pigmentation, skin response to UVR, hair texture, and facial features, the levels of genetic diversity genome-wide are very low. “Race” as a means to organize and conceptualize human genetic and phenotypic variation is thus only of limited utility. A more useful model within which to investigate human diversity, the population-genomic model explicitly recognizes that the genome is a composite of many local regions with diverse evolutionary histories. Dermatological differences among populations can provide the means to investigate the physiology of skin biology. Admixture mapping methods, some of the most statistically powerful approaches to gene discovery, are ideally suited to identifying the genetic factors underlying phenotypic differences among populations. Given many of the skin differences across the world’s populations are the result of local adaptation to the environment, locating and investigating these genes can and should give us many insights into the interaction of skin and the sun. Examples of will be given using the discoveries of the genes that have lightened the skin of Europeans and physical differences in skin pigmentation and skin responses across several populations.

EVOLUTIONARY ADAPTATION OF THE SKIN TO THE ENVIRONMENT

Mark SHRIVER, PhDAssociate Professor of Anthropologyand Genetics at Penn State University, State College, USA

EFFECT OF SUNLIGHT AND POLLUTION ON THE SKIN


Sunlight as it reaches the surface of the earth consists of ultraviolet (UV)-B, UVA, visible light and infrared. The ma-jor biologic effects of acute exposure to UVB radiation are cutaneous erythema and vitamin D synthesis, while UVA, tanning. Chronic effect of UVB is photocarcinogenesis, and UVA, photocarcinogenesis and photoaging. Recent stu-dies have also pointed out that longwaves UVA1 are more harmful than previously thought with huge impact in DNA le-sions formation, photoimmunosuppression and alterations of many biological functions. Other radiations can also be dele-terious and have to be taken into account such as Visible light which is needed for general illumination but now shown to be responsible for induced pigmentation lasting up to 3 months, and more pronounced in dark skinned individuals. Infrared A radiation has been shown to contribute to photoaging. Emerging data also show that air pollution has detrimental effects on human skin. Therefore, development of better and global protective measures against all these environmental injuries, UV rays and beyond, have to be considered for the future.

Henry W. LIM, MDC.S. Livingood Chair and ChairmanDepartment of DermatologyHenry Ford HospitalDetroit, Michigan, USA


AN INTEGRATED STRATEGY AGAINST ENVIRONMENTAL STRESS


Diversity of populations and skin colors, as well as variety of external stress require a broad and integrated strategy of pro-tection in each product and each use. To face this challenge, we will see, from the usual ones to the more innovative ones, technologies that allow us to broaden the scope of protection and to give an appropriate response.1. A broad and overall protection based on our current tool box for short-term developments. 2. Identification of innovative systems using all technical tools from filters to biological protective molecules.

Altogether these approaches will aim at offering a broader photoprotection by i) a physical surface photoprotection able to cover long UVA between 370 and 400 nm and ii) a biological photoprotection with appropriate anti-oxidants (AOX). AOX being no longer considered as formulation aids, but really as auxiliary of photoprotection, associated with the filters system and formulated so that their complementarity is expressed.

3. Evaluation of photoprotection efficacy provided by the overall system using biological and clinical end points including pigmentation.

4. The final dimension from efficacy to efficiency with a finished product combining photoprotection performance and an adequate texture for optimal conditions of use.

Didier CANDAU, PhDSenior Research Associate, Applied Research Anti-ageing and Photoprotection DepartmentL’Oréal Research and Innovation, Chevilly-Larue, France


STRETCHABLE BIOELECTRONICS FOR CONTINUOUS CHARACTERIZATION AND MONITORING OF SKIN HEALTH


Human skin is a living organ with soft, stretchable and dynamically changing characteristics; whereas wearable devices are largely planar, rigid and non-deformable. Here, we present novel materials, mechanics and designs for ultrathin skin-coupled sensors and microelectronics systems, called ‘epidermal electronics’, which can mechanically match the physical properties and curvilinear geometries of skin. We demonstrate microfabricated arrays of sensors configured in ultrathin, flexible formats for continuous monitoring of skin temperature, thermal and electrical conductivity, skin modulus, pH, and movement. Quan-titative analyses of strain over various anatomical locations and electronics performance under stress illustrate the utility of these systems to laminate on skin, for clinical diagnostics and continuous health monitoring applications. Sleep study analysis, continuous monitoring of sweat, physiology, and dermatologic analysis of skin mechanical properties are all enabled using this platform, thus highlighting promising new directions in skin health enabled with epidermal electronics.

Roozbeh GHAFFARI, PhDMC10 Technology Inc Co-Founder & Vice President, MIT Research Laboratory of Electronics, Los Angeles, USA


D I A M O N D S P O N S O R

www.congress.loreal.com/2015-wcd.phpwww.loreal.fr/

sun & environment: get connected, get … · the ma-jor biologic effects of acute exposure to...

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