suissepigs genetics gmbh & co. kg · • performance testing: the traits in the breeding goal...
TRANSCRIPT
SUISSEPIGS Genetics GmbH & Co. KG
Global Trading, Consulting & Services in Breeding Industry
WWW.SUISSEPIGSGENETICS.RU
Breeding program for dairy cattle
SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry
Elements of breeding program
• Breeding goal: what traits are important
and must be improved.
• Performance testing: the traits in the
breeding goal must be recorded
• Herd-book keeping: animal identification,
registration of inseminations and births
including a mother and a father
• Breeding value estimation: BLUP-animal
model with genomic selection
• Selection: compare breeding progress
with standards, defined in a breeding goal
03.08.2020 2
SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry
Breeding goal
• The breeding goal depends on the requirements of the
economic environment, the climatic conditions, animal
housing conditions and the feeding basis
• These dependencies vary from country to country
• Import genetics has only a very limited influence on the
breeding goals pursued in the foreign breeding program
03.08.2020 3
Breeding Value Estimation
• Breeding values cannot
simply be compared across
different countries
– Genotype-environment
interactions
– Different estimation
models
– Different trait definition
03.08.2020 4
SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry
Interbull: Genetic correlations between countries
Fat content – Holstein
03.08.2020 5
Correlations are significantly < 1.00
SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry
Genomic selection
03.08.2020 6
• SNP-effects estimated with and
without bull XY
• SNP-effects include kinship
• It is important to have a close
relationship between the
training data set and
candidates for selection
• SNP-effects shall be continuously
re-estimated
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−40 −20 0 20 40 60 80
−40
−2
00
20
40
60
80
DGZW ORG vs Wonderment
DGZWs ORG
DG
ZW
s W
on
derm
en
t
Mean24.82
Stdv
15.41
Mean
24.69
Stdv
15.4
Korrelation: 1Rangkorrelation: 1
Direct genomic breeding value (effect estimation WITHOUT bull XY)
DG
BV
(E
ffe
ct e
stim
atio
n W
ITH
bu
ll X
Y) Bull XY itself
Offspring
grandson
SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry
Genomic SelectionCrossbred population Simmental - Holstein
03.08.2020 7
Conclusion:
Genotypes are a
mirror-reflection of
the population
Simmental has hardly
any genetic link to the
training data set
Pure Simmental
Pure Holsteins
SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry
Conclusions
• Breeding values cannot simply be compared across
different countries.
• Genomic breeding values can only be estimated with
sufficient accuracy if the SNP-effects with a training
sample are calculated from the own population.
• The animals in the training sample must have traditional
BLUP breeding values based on their own population
and must have the closest possible genetic relationship
to the genotyped animals.
03.08.2020 8
SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry