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SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry WWW.SUISSEPIGSGENETICS.RU Breeding program for dairy cattle

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SUISSEPIGS Genetics GmbH & Co. KG

Global Trading, Consulting & Services in Breeding Industry

WWW.SUISSEPIGSGENETICS.RU

Breeding program for dairy cattle

SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry

Elements of breeding program

• Breeding goal: what traits are important

and must be improved.

• Performance testing: the traits in the

breeding goal must be recorded

• Herd-book keeping: animal identification,

registration of inseminations and births

including a mother and a father

• Breeding value estimation: BLUP-animal

model with genomic selection

• Selection: compare breeding progress

with standards, defined in a breeding goal

03.08.2020 2

SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry

Breeding goal

• The breeding goal depends on the requirements of the

economic environment, the climatic conditions, animal

housing conditions and the feeding basis

• These dependencies vary from country to country

• Import genetics has only a very limited influence on the

breeding goals pursued in the foreign breeding program

03.08.2020 3

Breeding Value Estimation

• Breeding values cannot

simply be compared across

different countries

– Genotype-environment

interactions

– Different estimation

models

– Different trait definition

03.08.2020 4

SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry

Interbull: Genetic correlations between countries

Fat content – Holstein

03.08.2020 5

Correlations are significantly < 1.00

SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry

Genomic selection

03.08.2020 6

• SNP-effects estimated with and

without bull XY

• SNP-effects include kinship

• It is important to have a close

relationship between the

training data set and

candidates for selection

• SNP-effects shall be continuously

re-estimated

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−40 −20 0 20 40 60 80

−40

−2

00

20

40

60

80

DGZW ORG vs Wonderment

DGZWs ORG

DG

ZW

s W

on

derm

en

t

Mean24.82

Stdv

15.41

Mean

24.69

Stdv

15.4

Korrelation: 1Rangkorrelation: 1

Direct genomic breeding value (effect estimation WITHOUT bull XY)

DG

BV

(E

ffe

ct e

stim

atio

n W

ITH

bu

ll X

Y) Bull XY itself

Offspring

grandson

SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry

Genomic SelectionCrossbred population Simmental - Holstein

03.08.2020 7

Conclusion:

Genotypes are a

mirror-reflection of

the population

Simmental has hardly

any genetic link to the

training data set

Pure Simmental

Pure Holsteins

SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry

Conclusions

• Breeding values cannot simply be compared across

different countries.

• Genomic breeding values can only be estimated with

sufficient accuracy if the SNP-effects with a training

sample are calculated from the own population.

• The animals in the training sample must have traditional

BLUP breeding values based on their own population

and must have the closest possible genetic relationship

to the genotyped animals.

03.08.2020 8

SUISSEPIGS Genetics GmbH & Co. KG Global Trading, Consulting & Services in Breeding Industry