successfully scaling up industrial fermentation of ... lubben.pdf · successfully scaling up no...
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Marcel LubbenPresident, Reverdia
Successfully Scaling Up Industrial Fermentation of Biosuccinium™
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Successfully Scaling UpNo technical scale-up without commercial scale-up
Create Market Pull
Create Trust
Technological scale-up
Commercial scale-up
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enabling sustainable materials
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Create Trust
Technological scale-up
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Utilizing the distinct and unique competencies of two leading companies
Create TrustReverdia: Powered by DSM + Roquette
• Top global starch and derivatives producer
• Biorefinery experts
• €3 billion Euros turnover
• Member of UN Global Compact
• Biotechnology leader
• Annual net sales of around €9 billion
• Top ranking Dow Jones Sustainability Index
Experts on the potential of biomass
Experts on using microorganisms to convert sugars from biomass into chemicals/materials
Biomass Biosuccinium Materials OEM Brand Owner
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Low-pH yeast technology enables economic commercial production
Creating TrustSelect best technology and use through entire scale-up
Best LCASimple & robust process
Flexible feedstock(1st and 2nd generation)
Consistent QualityBest economicsLow-pH yeast technology
Select best technology and use through entire scale-up – avoid changes halfway
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Large CO2 reduction potential with Biosuccinium™
Create TrustBiosuccinium™ Footprint Benchmarks
Executed by the Copernicus Institute at Utrecht University, the Netherlands
The adipic acid data is for a best in class plant with 98% N2O abatement.
Data is published in the Wiley Online Library (August 2013)
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Provide consistent supply with growing production capacity
Create TrustStatus Supply Chain
• Current Biosuccinium™ capacity about 10 kta• Expansion plans for next facility of about 50 kta by 2016
Biomass Biosuccinium Materials OEM Brand Owner
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Create TrustFermentation
No shortcuts in scale-up1. Pilot 2.Demo 3.First commercial
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Create Trust Product Recovery
Don’t solve everything at once but stick to order:1. Quality 2.COGS 3.Productivity increase
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Create Trust
Select best technology and use through entire scale-up – avoid changes halfway
No shortcuts in scale-up– Pilot– Demo– First commercial
Don’t solve everything at once but stick to
1. Quality2. COGS & LCA – minimize side stream
production3. Productivity increase
Be on-site during start-up – seamless transfer lab -> pilot -> demo -> commercial plant – no shortcuts
Summary
Technological scale-up
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Create Market
PullCommercial
scale-up
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Create Market PullAssembling the Value Chain
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In-house application development Support customer application development activities Identify impact on processes and downstream products Develop demonstrator end-use products Create market pull
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Create Market PullBiosuccinium™ Qualified in Multiple Applications
TPU = thermoplastic polyurethane; PU = polyurethanes; PBS = polybutylene succinate: new biopolymer; Spandex / Elastane = elastic fibers
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Polyurethanes Footwear mid and outer soles:
30 % bio-based
Alkyd paint Resin: biobased from 66% to 96%
– several renewables used Coating with dimethyl succinate
solvent: – reduction drying time ~40%.– hardness developed faster
Biosuccinium™ Demonstrators Help Create Awareness and Market Pull
Create Market PullDeveloping Demonstrators
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Create Market Pull
There is no such thing as being too early for market development
Deliver additional customer benefits next to the green benefit
Work the value chain! Continuous dialogue between
– Process– Quality– Customer feedback
COGS and quality equilibrium Believe in your offering!
Summary
Create Market Pull
Commercial scale-up
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Successfully Scaling UpNo technical scale-up without commercial scale-up
Create Market Pull
Create Trust
Technological scale-up
Commercial scale-up