SUBJECT INDEX ACTH

ectopic production of, 403 effect of, on steroid secretion and steroidogenic enzyme activities and expression, 855

ACTH/MSH like peptides in the treatment of cisplatin neuropathy, 179

Albumin binding globulin regulation of, secretion by human Sertoli cells in culture, 423

Aldosterone molecular genetic studies on the biosynthesis of, in humans, 981

Aminoglutethimide effect of, on aromatase inhibition, 641

Anabolic steroids a review of their effects on the muscles, possible mechanisms of action and use in athletics, 469

Androgen(s) tissue, and the endocrine autonomy of breast cancer, 167

Androgen insensitivity syndrome prenatal prediction of, using Exon 1 polymorphism of the androgen receptor gene, 659

16-Androstenes GC-MS studies of, 549

Angiotensin II -directed glomerulosa cell function in fetal adrenal cells, 847

Antiestrogen(s) ICI 182,780: a new, with clinical potential, 173 mechanisms of growth inhibition by, in human breast and endometrial cancer cells, 117

Antisteroids modulation of the agonist activity of, by a novel c/s-acting element, 43

Aromatase evaluation of the racemate and the enantiomers of a new highly active and selective, inhibitor of the aminoglutethimide type, 641 Exemestane (FCE 24304), a new steroidal, inhibitor, 137 in vitro potency and selectivity of the non-steroidal androgen, inhibitor CGS 16949A compared to steroidal inhibitors in the brain, 281 kinetic properties of, mutants Pro308Phe, Asp309Asn, and Asp309Ala and their interactions with, inhibitors, 693 regulation of human, cytochrome P450 gene expression, 923

Avidin-gene inducibility of, by progesterone is suppressed during estrogen-induced cytodifferentiation, 609

Brain in vitro potency and selectivity of the non-steroidal androgen aromatase inhibitor CGS 16949A compared to steroidal inhibitors in the, 281

Breast cancer abnormal estrogen receptor in clinical, 243 aromatization inhibition alone or in combination with GnRH agonists for the treatment of premenopausal, patients, 155 basic fibroblast growth factor (bFGF): mitogenic activity and binding sites in human, 87 clinical, new developments in selection and endocrine treatment of patients, 211 comparison of c-myc and HER2/neu amplification in human primary, 13 direct stimulation by estrogen of growth factor signal transduction pathways in human, cells, 111 growth factors in, : mitogenesis to transformation, 69 hormonal regulation of c-erb B-2 oncogene expression in, cells, 21 4-hydroxyandrostenedione treatment for postmenopausal patients with, 145 inhibition of oestrogen synthesis in postmenopausal women with, 149 plasma-borne specific inhibitor of the proliferation of human estrogen-sensitive, cells, 703 tissue androgens and the endocrine autonomy of, 167

XIII

XIV Subject Index

Cancer hypcrcalcemia in, 123 modulation of tumour-induee~ bone resorption by bisphosphonates, 131

Cholesterol hormonal and stressor-associated changes in porcine adrenocortical, ester hydrolase activity, 725 ontogcnesis of, side-chain cleavage activity, in the ovine adrenal during late gestation, 303 regulation of, movement to mitochondrial cytochrome P450scc in steroid hormone synthesis, 751

Cortisol determination of urinary, with three commercial immunoassays, 573 familial and iatrogenic, receptor resistance, 385 metabolism of, by human liver in vitro, 713

Cortisol-biotin conjugate synthesis of a, and evaluation as tracer in an immunoassay for salivary cortisol measurement, 683

CRF ectopic production of, 403

Cushing's disease unrestrained production of POMC and its peptide fragments by pituitary corticotroph adenomas in, 379

Cytochrome P450 comparison of human fetal hepatic and adrenal, activities, 335 hormone stimulated steroid biosynthesis in granulosa cells studied with a fluorogenic probe for, 479 immunochemical specificity of placental NADPH, reductase in neoplastic and non-neoplastic human tissue, 515 in guinea pig adrenal, 863 modes of regulation of liver-specific steroid metabolizing, 1055 participation of a, enzyme from the 2C subfamily in progesterone 21-hydroxylation in sheep liver, 591 steroid metabolism by constitutive, 1023

Cytokines potential relevance of, to ovarian physiology, 439

Cytoskeleton role of, in the regulation of steroidogenesis, 769

Danazol induction of progesterone receptor by, in cultured cancer cells and the rat uterus, 289

1,25-Dihydroxyvitamin D3 characterization of human, receptor antipeptide antibodies, 649

eDNA expression chimeric, and site directed mutagenesis studies of CYP2A1 and CYP2A2, 1037

DNA antiestrogen-liganded estrogen receptor interaction with estrogen responsive element, in vitro, 249 comparison of cAMP-responsive, sequences and their binding proteins, 931 magnetic, affinity purification of ecdysteroid receptor, 629

Endometrial cancer growth-promoting effects of progesterone in a human, cell line (Ishikawa-Var I), 635 mechanisms of growth inhibition by antiestrogens and progestins in human breast and, cells, 117

Epitestostcrone a potent competitive inhibitor of C2~-steroid side chain cleavage in the testis, 721

ERG 11 gene molecular genetic analysis of the, in Saccharomyces cerevisiae, 1107

Estradiol modulatory actions of, on phorbol ester-stimulated LH secretion from cultured rat pituitary cells, 619

17fl-Estradiol dehydrogenase purification, characterization and subcellular localization of membrane-bound, of porcine endometrial cells, 1089

Estrogen(s) direct stimulation by, of growth factor signal transduction pathways in human breast cancer cells, I 1 l

Estrogen responsive element antiestrogen-ligande~l estrogen receptor interaction with, DNA in vitro, 249

Subject Index XV

Gene(s) analysis of the duplicated human Ot/P450c21/X, cluster, 961 bovine CYP17 and CYPllA and human CYP21B, 931 promoter elements of the mouse 21-hydroxylase (Cyp-21), 937 steroids and growth promoting factors in the regulation of expression of, 63

Gene expression changes in, during senescence of adrenocortical cells in culture, 951 effect of ACTH on steroid secretion and steroidogenic enzyme activities and, 855 hormonal regulation of steroidogenic enzyme, in Leydig cells, 895 of 3~-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes, 805 regulation of human aromatase cytochrome P450, 923 regulation of, of enzymes controlling aldosterone synthesis in rat adrenal, 837 role of cytokines in the regulation of Leydig cell P450c17, 907

Glucocorticoid(s) -dependent hypertension, 409

Glucuronosyltransferases steroid UDP, 1099

GnRH aromatization inhibition alone or in combination with, agonists for the treatment of premenopausal breast cancer patients, 155

Growth factor(s) basic fibroblast, : mitogenic activity and binding sites in human breast cancer, 87 direct stimulation by estrogen of, signal transduction pathways in human breast cancer cells, 111 in breast cancer: mitogenesis to transformation, 69 in the regulation of expression of genes and gene networks, 63

Growth hormone mechanism of, regulation of sexually dimorphic P450 enzymes in rat liver, 1045

4-Hydroxyandrostenedione treatment for postmenopausal patients with breast cancer, 145

25-Hydroxydihydrotachysterol synthesis and biological activity of, 363

21-Hydroxylase promoter elements of the mouse, (Cyp-21) gene involved in cell-selective and cAMP-dependent gene expression, 937

17~-Hydroxylase/17,20-1yase deficiency molecular basis of, 973

1 lfl-Hydroxylation of 17~-21-dihydroxypregna-l,4-diene-3,20-dione 17-acetate in dependence of the inducer structure, 543 molecular biology of, 827

18-Hydroxylation in the Y-1 adrenal cell line: response to ACTH and to culture conditions, 535

3~,-Hydroxysteroid dehydrogenase molecular cloning of multiple, related enzymes from rat liver, lung and kidney, 1083 purification and properties of human hepatic, 343 structure, function and tissue-specific gene expression of, 805

3fl-Hydroxysteroid dehydrogenase ontogeny and subcellular localization of, in the human and rat adrenal, ovary and testis, 45 l regulation by dexamethasone of the, activity in adult rat Leydig cells, 565

1 lfl-Hydroxysteroid dehydrogenase molecular biology of, enzymes, 827

17fl-Hydroxysteroid dehydrogenase deficiency: an inherited form of male pseudohermaphroditism, 989

Hypothalamo-pituitary-gonadal system actions of acetyl-L-carnitine on the, in female rats, 351

Lcydig cells control of steroidogenesis in, 445 effects of serum and serum lipoproteins on testosterone production by rat Leydig cells in vitro, 581 hormonal regulation of steroidogenic enzyme gene expression in, 895

XVI Subject Index

regulation by dexamethasone of the 31/-hydroxysteroid dehydrogenase activity in adult rat, 565 role of cytokines in the regulation of, P450c17 gene expression, 907

Leydig tumor control of steroidogenesis in MA-10 mouse, cells, 319 regulation of expression of 3fl-hydroxysteroid dehydrogenase is mediated by cAMP in H540 rat, cells, 915

Liarozole (R 75 251) an antitumoral agent which inhibits retinoic acid breakdown, 197

Lipoprotein receptors and steroidogenesis, 395

Mammary adenocarcinomas high frequency of, in metallothionein promoter-human growth hormone transgenic mice, 237

Mammary cancer cells regulation of androgen receptor messenger ribonucleic acid and protein level by steroid hormones in human, 599

Male pseudohermaphroditism 17/~-hydroxysteroid dehydrogenase: an inherited form of, 989

MCF-7 cells covalent labeling of proteins by 17//-estradiol, retinoic acid, and progesterone in the human breast cancer, 489 tamoxifen induced changes in, of human breast cancer, 189

mRNA regulation of androgen receptor, level by steroid hormones in human mammary cancer cells, 599

Oncogene(s) c-erb B-2

hormonal regulation in, expression in breast cancer cells, 21 receptor, in tumor cells, 1

c-myc amplification in human primary breast cancer, 13

erb B-2 and its ligands in growth control of malignant breast epithelium, 229

HER2/neu amplification in human primary breast cancer, 13

neu/erb B-2 signal transduction by the, a potential target for anti-tumor therapy, 95

ras + myc -induced mouse prostate carcinomas, 79

Wnt gene family in tumorigenesis and in normal development, 9

transformed granulosa cells as a model system for the study of steroidogcnic processes, 875

Peptide hormones novel antitumor, and their effect on signal transduction, 105

P-450s alteration of the substrate specificity of mouse 2A, by the identity of residue-209, 1031

P-450scc regulation in pig granulosa cells, 869

Phorbol ester effect of estradiol and progesterone on, -stimulated LH secretion from cultured rat pituitary cells, 619

Pituitary tumor cell line effects of retinoic acid on, 263

Progesterone adrenergic influence on, metabolism in the rat ovary, 885 growth-promoting effects of, in a human endometrial cancer cell line (Ishikawa-Var I), 635 modulatory actions of, on phorbol ester-stimulated LH secretion from cultured rat pituitary cells, 619

Progesterone antagonists the antitumor potency of, is due to their differentiation potential, 203

Subject Index

Progestin(s) -induced fatty acid synthetase in human mammary tumors, 223 mechanisms of growth inhibition by, in human breast and endometrial cancer cells, 117

Prostate carcinoma androgen sensitivity and gene expression in ras + myc-induced mouse, 79

Prostatitis soy of dietary source plays a preventive role against the pathogenesis of, in rats, 557

XVII

Receptor(s) androgen

domain functions of the, 37 prenatal prediction of androgen insensitivity syndrome using Exon 1 polymorphism of the, gene, 659

angiotensin II characterization and coupling of, subtypes in cultured bovine adrenal fasciculata cells, 271

1,25-dihydroxyvitamin D3 characterization of human, antipeptide antibodies, 649

ecdysteroid magnetic DNA affinity purification of, 629

estrogen(s) aberrant, species in human meningioma tissue, 57 immunohistochemical detection of human, with region D-specific anti-peptide antibodies, 31 l interaction of, with DP-TAT-59, an active metabolite of new triphenylethylene derivative (TAT-59), 507 interaction of, with estrogen responsive element DNA in vitro, 249

glucocorticoid, 389 progesterone

induction of, by Danazol in cultured cancer cells and the rat uterus, 289 somatostatin

in human cancer: incidence, characteristics, functional correlates and clinical implications, 27 Retinoic acid

covalent labeling of proteins by, in the human breast cancer cell lines MCF-7 and MCF-7/Adr R, 489 effect of liarozole (R 75 251) on, 197 effects of, on estrogen- and thyroid hormone-induced growth in a newly established rat pituitary tumor cell line, 263

Sertoli germ cells interactions in the human testis, 419

Sex hormone binding globulin steroidal and non-steroidal factors in plasma, regulation, 431

Sex steroid hormones cartilage responsiveness to, 415

Somatostatin receptor imaging in the diagnosis and treatment of neuroendocrine tumors, 185

Steroids(s) current research on, metabolism: transition from biochemistry to molecular-cell biology, 745 enzymes involved in, reduction in vertebrates, invertebrates and procaryonts, 665 1 l~-hydroxylation by a fungal microsomal cytochrome P450, 1117

Steroid- 1-dehydrogenase of Rhodococcus erythropolis: purification and N-terminal amino acid sequence, 297

Steroid enzyme-linked immunoassays biotin-hydrazide derivatives for the development of, 523

Steroid hormone(s) interplay of, receptors and transcription factors on the mouse mammary tumor virus promoter, 365 regulation of androgen receptor messenger ribonucleic acid and protein level by, in human mammary cancer cells, 599

Steroidogenesis extraglandular hormonal, in aged rats, 1095

Steroidogenic enzymes structure, function, and role in regulation of steroid hormone biosynthesis of, 779

XVIII Subject Index

Tamoxifen changes induced by, in MCF-7 human breast cancer cells, 189

Testosterone effects of serum and serum lipoproteins on, production by adult rat Lcydig cells/n vitro, 581

Transcription factors interplay of steroid hormone receptors and, on the mouse mammary tumor virus promoter, 365

Vitamin D characterization and regulation of, hydroxylases, 1073

Vitamin D3 isolation and identification of, in Solarium malacoxylon incubated with ruminal fluid, 677

Zymosterol a simple method for the isolation of, from a sterol mutant of Saccharomyces cerevisiae, 741

We wish to express our deep thanks to the following persons for their kind collaboration in reviewing papers for the The Journal of Steroid Biochemisry and Molecular Biology: Drs J. B ~ , F_ziinburgh, Scotland; A. BELANOER, Quebec, Canada; J. CxRt,vr~T-DuKE, Huddinge, Sweden; K. C. CHm~6, New York, U.S.A.; C. Fea~T~, Washington, U.S.A.; M. GOWNDAN, Quebec, Canada; R. A. HAWKINS, Edinburgh, Scotland; L. KI~Y, New York, U.S.A.; L. A. MILLmL Denver, U.S.A.; C. MONDe, New York, U.S.A.; J. SXF.Z, Lyon, France; B. SCHXCHTER, New York, U.S.A.; J. SnvL,,gD, Quebec, Canada; and V, LifO-THE, Quebec, Canada.