study program 2016/2017 subjects of the 3-4. … · 6 2 investigation of the behavior of terner...

UP FP Pharmacy major – obligatory subjects of the 3-4.. semester - Course descriptions – academic year of 2016/2017

1

University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2016/2017

Subjects of the 3-4. semesters

(obligatory subjects and criterion requirements)


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3rd semester

OPA-FZ2 Physical Chemistry 2 ____________________________________________________________________________ 3

OPA-KD1 Colloidics 1 ___________________________________________________________________________________ 5

OPA-SV1 Organic Chemistry 1 ____________________________________________________________________________ 7

OPO-A2S Anatomy, Histology and Embryology 2 _____________________________________________________________ 11

OPO-EN1 Human Physiology 1 ___________________________________________________________________________ 13

OPO-GN1 Pharmacobotany 1 _____________________________________________________________________________ 19

4th semester

OPA-G1B Pharmaceutical Biochemistry 1 ___________________________________________________________________ 21

OPA-MAN Instrumental Analysis ___________________________________________________________________________ 23

OPA-SK2 Organic Chemistry 2 ___________________________________________________________________________ 26

OPG-GI1 Basic Principles of Pharmacy _____________________________________________________________________ 30

OPO-EN2 Human Physiology 2 ___________________________________________________________________________ 32

OPO-FA2 Pharmacobotany 2 _____________________________________________________________________________ 38

OPR-SG1 Professional Practice 1 __________________________________________________________________________ 41

OPR-HUF-O Final Examination in Hungarian Pharmaceutical Terminology - oral ____________________________________ 43

OPR-HUF-W Final Examination in Hungarian Pharmaceutical Terminology - written __________________________________ 1

ATT1-2-3-4 Physical Education 1-2-3-4 _____________________________________________________________________ 2


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OPA-FZ2 PHYSICAL CHEMISTRY 2

Course director: DR. GÉZA NAGY, professor

Faculty of Natural Sciences - Department of General and Physical Chemistry

3 credit ▪ midsemester grade ▪ Basic module ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 0 lectures + 42 practices + 0 seminars = total of 42 hours

Course headcount limitations (min.-max.): 4 – 36 Prerequisites: OPA-FZ1 completed

Topic

The students completing the course will get experience in carrying out basic physical chemical measurements. They will learn the ways

of handling instruments, taking notes, evaluating experimentally taken data. Before the practice each student obtains an experimental

task to be solved. In home reading they refresh the theoretical back ground and study the instructions. Before beginning the laboratory

work they complete a short test to prove their level of understanding the theory and practice of the task to be solved. They work alone

following the written instructions and guidelines of the instructor. The data, calculations, graphs, tables and conclusions are introduced

into a carefully prepared note book. The tasks are taken from chapters of physical chemistry studied in course Physical chemistry I:

Thermo dynamics, reaction kinetics, electro chemistry, equilibrium, properties of solutions, determination of indicator exponents.

Different instruments like electrochemical work stations, spectro photometers, calorimeters, gas volume measurements, conductometric

apparatus, pH meter and other basic „small” laboratory equipment are used.

Conditions for acceptance of the semester

Maximum of 10 % absence of practices allowed.

Mid-term exams

Making up for missed classes

One week absence can be tolerated if the experiment is performed in a supplementary time (last week)

Reading material

- Obligatory literature

P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722

- Literature developed by the Department

The description of the experimental work is given in the home page of the department

- Notes

The description of the experimental work is given in the home page of the department

Laboratory manual downloaded from the web site of the Dept. for General and Physical Chemistry of Faculty of Sciences at the

University of Pécs

- Recommended literature

D. Freifelder: Physical Chemistry for Students of Biology and Chemistry, Science Books International Inc. ISBN 0 86720-002-2

Lectures

Practices

1 1 Determination of solubility, calculation of the differential dissolution heat



4 2 Investigation of the behavior of terner (three component) systems, preparation solubility triangle diagram



7 3 Investigation of the behavior Reaction heat measurement using adiabatic calorimeter



10 4 Investigation of kinetics of hydrolysis with conductometryc measurements



13 5 Investigation of decomposition kinetics of a drug molecule



16 6 Investigation of homogeneous catalysis (oxidation of ascorbic acid)




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19 7 Study of drug dissolution kinetics from pharmaceutical pills using spectrophotometric method



22 8 Potentiometry, pH measurement, investigation of selectivity of ion selective electrodes, measurement of redox potential.



25 9 Measurement of conductivity in electrolytes



28 10 Investigation of kinetics of electrode processes, cyclic voltammetry, current - electrode potential curves, Cottrell form, Tafel’s equation

29 10 Investigation of kinetics of electrode processes, cyclic voltammetry, current - electrode potential curves, Cottrell form,

Tafel’s equation

30 10 Investigation of kinetics of electrode processes, cyclic voltammetry, current - electrode potential curves, Cottrell form, Tafel’s equation

31 11 Determination of solubility products using potentiometric measurements



34 12 Determination of dissociation coefficient of color indicators using spectrophotometric method.



37 13 Computer modeling chemical reactions



40 14 Determination of diffusion coefficients



Seminars

Exam topics/questions

There is no exam to be taken for passing the laboratory practice

Participants

Dr. Nagy Géza (NAGFAAP.PTE), Dr. Nagyné Dr. Zengő Lívia (NAZLAAF.PTE)


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OPA-KD1 COLLOIDICS 1

Course director: DR. BARNA SZILÁRD KOVÁCS, associate professor

Faculty of Natural Sciences - Department of General and Physical Chemistry

2 credit ▪ semester exam ▪ Basic module ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 3 – Prerequisites: OPA-AT1 completed + OPA-FZ1 completed

Topic

Learning about the types, structure, stability, chemical and physical-chemical properties and about laws of interaction of colloidal systems.


Two written tests should be completed (min. 50%) during the semester.

Mid-term exams


Reading material



- Notes


D. J. Shaw: Introduction to Colloid and Surface Chemistry, 4th ed. (or later), Butterworth-Heinemann, Oxford 1992.,

D. F. Evans, H. Wennerström: The Colloidal Domain: Where Physics, Chemistry, Biology and Technology Meet, 2nd ed., Wiley-

VCH, New York 1999.

D. H. Everett: Basic Principles of Colloid Science, RSC, London 1988.

Lectures

1 The colloidal state

Dr. Kovács Barna Szilárd

2 Classification of colloidal systems


3 The structure of interfaces


4 Interfacial phenomena.


5 Surface tension.


6 Gas/liquid interface.


7 Interface of solution, phase boundary


8 Liquide/liquide interfaces


9 Solid/liquide interface


10 Capillary condensation. Wetting, wetting materials.


11 Adsorption phenomenon


12 Heat of adsorption, adsorption equations


13 Adsorption isotherms (Freundlich, Langmuir, Langmuir-Hückel, BET),


14 Adsorption hysteresis


15 Electric double-layer, electrokinetic potential



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16 Electrokinetic phenomena


17 Properties of dispersed systems: distribution, morfology, degree of dispersity


18 Stability of colloidal systems, parameters that affect the stability


19 Aerosols, foams


20 Emulsions, suspensions


21 Reology, properties and methodology.


22 Macromolecular colloids


23 Properties, examination methods of macromolecular colloids


24 Association colloids


25 Micelle formation


26 Parameters that affect the micelle formation


27 Liposomes


28 Langmuir Blodget films, LB technique.


Practices

Seminars


The colloidal state, classification of colloidal systems

The structure of interfaces, interfacial phenomena. Surface tension.

Gas/liquid interface. Interface of solution, phase boundary, liquide/liquide interfaces

Solid/liquide interface, capillary condensation. Wetting, wetting materials.

Adsorption phenomenon, heat of adsorption, adsorption equations, adsorption isotherms (Freundlich, Langmuir, Langmuir-Hückel,

BET), adsorption hysteresis.

Electric double-layer, electrokinetic potential, electrokinetic phenomena.

Properties of dispersed systems: distribution, morfology, degree of dispersity. Stability of colloidal systems, parameters that affect the

stability

Aerosols, foams, emulsions, suspensions.

Reology, properties and methodology.

Macromolecular colloids, properties, examination methods.

Association colloids, micelle formation, parameters that affect the micelle formation, liposomes, Langmuir Blodget films, LB technique.

Participants


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OPA-SV1 ORGANIC CHEMISTRY 1

Course director: DR. KÁLMÁN HIDEG, professor emeritus

Department of Organic and Pharmacological Chemistry

6 credit ▪ semester exam ▪ Basic module ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 2 – 60 Prerequisites: OPA-AN1 completed + OPA-AT1 completed

Topic

This subject is a part of chemistry basics. Its aim to present the nomenclature, structure, physical and chemical properties, synthesis,

reaction mechanisms and application of organic compounds.


During the semester students have to accomplish the preparative works and written tests. They have to document the experiments in their

exercise book.

The organic chemistry laboratory course will be graded (1-5), based on the two written tests on 6th and 11th week, first of all. The

evaluation can be modified by grades of semi-micro preparations, success of unknown identification as well as the outlook of the records

of exercise book.

Mid-term exams

Students have two extra dates to accomplish the written tests of laboratory course.


Students have to contact their lab TA within 48 hours of missing lab to make the necessary arrangements.

Reading material


John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th ed., Thomson Brooks, Belmont, 2007.


Kálai, T., Bognár, B. Organic Chemisry Laboratory Manual, Dept. of Org. and Med. Chem., Medical Faculty, University of Pécs, 2010.

- Notes


T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.

William H. Brown: Organic Chemistry, Saunders College Publishing, Fort Worth, 1995.

Charles F. Wilcox, Jr., Mary F. Wilcox: Experimental Organic Chemistry: a Small-scale Approach, 2nd ed., Prentice-Hall, London, 1995.

Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory with Multistep and Multiscale Syntheses, 3rd ed., Wiley, New York, 1994.

Lectures

1 The system of organic compounds, functional groups, reaction mechanisms.

Dr. Pápayné Dr. Sár Cecília





4 Alkanes - Orbital hybridization and the structure of alkanes; Nomenclature, physical and chemical properties, conformation.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

7 Unsaturated hydrocarbons - sp2 and sp hybridization, nomenclature, physical properties, reactions and synthesis of alkenes and

alkynes.

Dr. Hideg Kálmán

8 Unsaturated hydrocarbons - sp2 and sp hybridization, nomenclature, physical properties, reactions and synthesis of alkenes and

alkynes.

Dr. Hideg Kálmán


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9 Unsaturated hydrocarbons - sp2 and sp hybridization, nomenclature, physical properties, reactions and synthesis of alkenes and alkynes.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

13 Importance of unsaturated hydrocarbons in industry and biology - polymerization, isoprene, terpenes, steroids, carotenoids.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

16 Aromatic compounds - the structure of benzene, Hückel’s rule. Electrophilic aromatic substitution reactions.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

19 Alkyl halides - the character of C-X bonds, synthesis and reactions of alkyl halides (substitution, elimination); Organic halides in the environment.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

22 Organometallic compounds - their importance in organic syntheses (Mg, Na, Li, Zn, Si, Cu, Cd compounds).

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

25 Alcohols, phenols, ethers - Structure, physical and chemical properties, reactions; Their biological importance.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

28 Stereochemistry: isomerism, configuration, chirality.






31 Sulfur containing compounds: Physical, chemical properties, importance in biological processes (in amino acids, peptides, methylation in biology, AcCo-A, drugs).







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34 Aliphatic and aromatic nitro, azo and diazo compounds: Structure, reactions, significance in organic syntheses.

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

37 Amines; nomenclature, physical and chemical properties, basicity, preparation.

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

40 Biologically active amines; Alkaloids, nitrogen containing drugs and hormones.

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

Practices

1 General instructions for work in the laboratory, safety precautions. Introduction to use of common laboratory apparatus. Characteristic reactions of alkanes, alkenes and alkynes.



4 Basic laboratory operations I.: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation,

determination of the melting point).

5 Basic laboratory operations I: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation,

determination of the melting point).

6 Basic laboratory operations I: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation, determination of the melting point).

7 Basic laboratory operations II: Separation of dies with column chromatography; Identification of 1st unknown compound. Characteristic tube reactions of aromatic hydrocarbons.



10 Basic laboratory operations III: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the boiling point); Characteristic tube reactions of alkyl halides.

11 Basic laboratory operations III: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the

boiling point); Characteristic tube reactions of alkyl halides.

12 Basic laboratory operations III.: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the boiling point); Characteristic tube reactions of alkyl halides.

13 1st written test; Synthesis of p-bromo-acetanilide and p-nitro-acetanilide.



16 Characteristic tube reactions of alcohols, phenols and ethers.



19 Synthesis of fluorenol with reduction and fluorenone with oxidation; Identification of 2nd unknown compound;



22 Basic laboratory operations IV: Continuous extraction, thin layer chromatography, measurement of optical activity, infrared spectroscopy. Isolation of piperine.




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25 Preparation of 4-amino-benzenesulfonamide and nitrobenzene.






31 2nd written test. Characteristic reactions of amines.



34 Preparation of anthranilic acid; Identification of 3rd unknown compound.



37 Preparation of 2-iodobenzoic acid;



40 Evaluation.

41 Evaluation.

42 Evaluation.

Seminars


1.) Alkanes: Orbital hybridization and the structure of alkanes; Nomenclature, physical and chemical properties, combustion, free radical chlorination, conformation, cycloalkanes, type of ring strains, demonstrate with examples.

2. Unsaturated hydrocarbons: sp2 and sp hybridization, nomenclature, physical properties, reactions and synthesis of alkenes and alkynes. Electrophilic addition, Markovnikov’s rule, 1,2- and 1,4-addition, conjugated and cumulated dienes.

3. Importance of unsaturated hydrocarbons in industry and biology; polymerization, isoprene, terpenes, steroids, carotenoids, polymers,

rubber

4. Aromatic compounds: the structure of benzene, Hückels rule. Electrophilic aromatic substitution reactions. (Nitation, sulfonation,

bromination, Friedel-Crafts reactions), direction rules, classification of substituents, polyaromatics: examples, their chemical reactions aromatic electophilic substitution, oxidation.

5. Alkyl halides: the character of C-X bonds, physical properties, reactivity of alkyl halides, synthesis of alkyl and aromatic halides, and reactions of alkyl halides (substitution, elimination); Organic halides in the environment.

6. Organometallic compounds: their structure, their importance in organic syntheses (Mg, Na, Li, Si, Cu, Cd compounds).

7. Alcohols, phenols, ethers: Structure, physical and chemical properties, reactions; Their biological importance.

8. Stereochemistry: isomerism, absolute and relative configuration, chirality, racemates, diastereomers, polarimetry, resolution.

9. Sulfur containing compounds: Physical, chemical properties, importance in biological processes (in amino acids, peptides, methylation in biology, AcCo-A, drugs, sulfonamides, penicillin, cefalosporin).

Participants

Dr. Bognár Balázs (BOBGAAT.PTE)


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OPO-A2S ANATOMY, HISTOLOGY AND EMBRYOLOGY 2

Course director: DR. ANDREA PETHŐ-LUBICS, associate professor

Department of Anatomy

2 credit ▪ semester exam ▪ Pharmaceutical biology and medical theoretical knowledge module ▪ autumn semester ▪ recommended semester: 3


Course headcount limitations (min.-max.): 1 – 100 Prerequisites: OPO-A1G completed

Topic

Anatomy and histology of the reproductive and endocrine organs. Macroscopic and microscopic structure of the nervous system. General embryology.


The participation in both the lectures and the practices of the course is obligatory. The semester will be only accepted, if the number of

absences is less than 25% of the total number of classes (less than 7x45 min.)

The grade will be determined by the result of the anatomy end-semester test. The retakes are oral (B, C or D chances).

Mid-term exams


Not possible

Reading material


http://an-server.pote.hu



- Notes




Lectures

1 Male genital organs.

Dr. Kiss Péter

2 Female genital organs 1. Ovarium, tuba uterina, uterus. The ovulation and the menstruation cycle.

Dr. Tamás Andrea

3 Female genital organs 2. Pregnancy, placenta. Vagina, external genital organs.

Dr. Tamás Andrea

4 The main parts of the human development. Main steps during the zygote and the embryonic period.

Dr. Kiss Péter

5 Fetal period. Signs of the maturity of the newborn baby. Malformations and their causes.

Dr. Pethőné Dr. Lubics Andrea

6 Parts of the nervous system. Peripheral nervous system.

Dr. Tóth Pál

7 Macroscopic structure of the central nervous system. (Main parts, ventricles, meninges, blood supply)

Dr. Tóth Pál

8 Nervous tissue.

Dr. Tóth Pál

9 Sensory pathways.

Dr. Gaszner Balázs

10 Motor pathways.

Dr. Gaszner Balázs

11 The endocrine glands.

Dr. Tamás Andrea

12 The autonomic nervous system.

Dr. Pethőné Dr. Lubics Andrea

http://an-server.pote.hu/





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13 Structure of the visual system.

Dr. Horváth-Opper Gabriella

14 Structure of the auditory and the vestibular system.

Dr. Horváth-Opper Gabriella

Practices

1 Anatomy: organs of the lesser pelvis

2 Anatomy: organs of the lesser pelvis

3 Histology: ovary, uterus, vagina

4 Histology: testis, prostate gland

5 Anatomy: spinal cord

6 Anatomy: meninges, cranial nerves

7 Anatomy: macroscopic structure of the brain

8 Anatomy: macroscopic structure of the brain

9 Histology: peripheral nerve, spinal cord

10 Histology: cerebellum, neocortex

11 Histology: pituitary gland

12 Histology: thyroid gland, suprarenal gland

13 Histology: eye, inner and middle ear with models

14 Histology: eye, inner and middle ear (slides)

Seminars



Participants

Dr. Farkas József (FAJHAAO.PTE), Dr. Jüngling Adél (JUARAAO.PTE), Dr. László Eszter (LAEOAAO.PTE), Kovács László Ákos (KOLQAAO.PTE)



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OPO-EN1 HUMAN PHYSIOLOGY 1

Course director: DR. ZOLTÁN KARÁDI, professor

Department of Physiology



Course headcount limitations (min.-max.): 1 – 200 Prerequisites: OPO-AF2 parallel + OPO-MB2 completed

Topic

The most important mission of the Physiology Course in medical education is to familiarize students with the attributes of healthy functions of the living organism.

While acquiring knowledge about the most important functional characteristics of the human body the students can rely on their prior studies in biology, biophysics, chemistry-biochemistry and anatomy.

During the semester we introduce the most important elements of functioning of the organs and organ systems, as well as their cooperation

also required to adapting to the environment, and the factors affecting these processes.

Special emphasis is placed on the neural and humoral regulatory processes of these life-functions, which are vital to maintain and preserve the homeostasis of the organism.

With the transfer of all this knowledge we would like to mould a holistic attitude and thinking of students, which will enable them to

better understand the functions of the now healthy, however, later dysfunctional human organism.


Maximum of 15 % absence allowed

Mid-term exams

Written test on the 11th week Friday at 16:00.


The missed lab practice is advised to be covered by joining another group while the same topic is on schedule.

Reading material


J.E. Hall: Guyton and Hall Textbook of Medical Physiology, 12th edition, 2013


Figures of the lectures given are available on the homepage of Institute of Physiology and on the Neptun Meet Street.

Important messages on new information will be announced at the lectures and will be sent to you by course mails.

Please always find the current updated information and study materials on the homepage of the Institute of Physiology (physiology.aok.pte.hu).

- Notes

Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practices 1, internet study material, printable notebook, 2014

Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practice Worksheets 1, internet study material, printable notebook, 2014


L.S. Costanzo: Physiology, 5th edition, 2014

W.F. Ganong: Review of Medical Physiology, 2012, Appleton and Lange, Lange Medical Publications

Fonyó: Principles of Medical Physiology, Medicina Publishing, 2002

J.B. West (ed.): Best and Taylor’s Physiological Basis of Medical Practice, Williams and Wilkins, 1998

Lectures

1 Introduction. Principles of the homeostatic regulations.

Dr. Környei József László

2 Cellular transport processes. Humoral control mechanisms.


3 Basics of electrophysiology. Equilibrium potential, electrotonic potentials and action potential.

Dr. Buzás Péter

4 Fluid distribution in the body. The blood.

Dr. Vértes Zsuzsanna

5 Anorganic and organic blood constituents.


6 Structure and metabolism of hemoglobin. Metabolism of iron.

Dr. Nagy Bernadett


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7 The physiological role of leukocytes.

Dr. Nagy Bernadett

8 Mechanism of blood coagulation.

Dr. Szabó István

9 Blood group systems.

Dr. Szabó István

10 The cardiac cycle. Generators and conductors of impulses in the heart.


11 Electrocardiogram.

Dr. Gálosi Rita

12 Distribution of blood volume, pressure flow and resistance in the heart. Heart sounds.


13 Cardiac output and cardiac work.


14 Distribution of blood volume, pressure flow and resistance. Blood pressure. Arterial pulse.

Dr. Ábrahám István Miklós

15 Circulation through the capillaries. Circulation in the veins. The formation, pressure and flow of lymph.

Kóbor Péter

16 Pulmonary circulation, cerebral circulation. Circulation of the skin and skeletal muscle. Splanchnic circulation. Coronary

circulation.

Kóbor Péter

17 Neural and humoral regulatory mechanisms of the cardiovascular system. Homeostatic regulation of the cardiovascular system.

Dr. László Kristóf

18 Mechanics of respiration Intrathoracic pressure. Compliance. Respiratory volumes. Dead spaces.


19 Gaseous exchange in the lungs and tissues. Chemical control of respiration. O2 and CO2 transport mechanism and pH regulation.


20 Neural regulatory mechanisms of respiration. Mechanisms of acclimatization.

Petykó Zoltán

21 The gastrointestinal tract. Function and control of salivary secretion. The stomach. Gastric secretion.

Dr. Buzásné Dr. Telkes Ildikó

22 Duodenal processes. Biliary secretion. Secretion and absorption in the small intestine.


23 Liver functions.

Dr. Ollmann Tamás

24 Secretion and absorption in the large intestine. Formation of the feces. Digestion and absorption of different nutrients. Vitamins.

Péczely László Zoltán

25 Humoral and neural control of the gastrointestinal system.


26 Dynamics of glomerular filtration. Plasma clearance. Renal blood flow. Extraction ratio. Filtration fraction.


27 Renal circulation. The renin-angiotensin system.


28 Tubular processes. Concentrating and diluting mechanisms. Osmoregulation.


29 Fluid volume regulation of the body. The mechanisms of urination.


30 Acid-base regulation.

Dr. Jandó Gábor

31 Energy balance. Metabolism. Nutrition. Body mass regulation.


32 Body temperature of man. Hyperthermia, fever.


33 Peripheral control of body temperature. Central control mechanisms of body temperature.


34 The hypothalamo-hypophyseal system.


35 Anterior pituitary hormones.



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36 Cellular mechanisms of hormone action.


37 Hormonal regulation of female sexual functions.

Dr. Lengyel Ferenc

38 Pregnancy. Lactation.

Dr. Lengyel Ferenc

39 Hormonal regulation of male sexual function. Erection, ejaculation, coitus. Puberty. Climacteric.

Kóbor Péter

40 Humoral and central neural control of sexual behavior.

Kóbor Péter

41 Functions of posterior lobe of pituitary gland.


42 Thyroid physiology.


Practices

1 Getting acquainted with the laboratory. General information, schedules. Personal- and equipment safety rules. Animal care regulations.

2 Getting acquainted with the laboratory. General information, schedules. Personal- and equipment safety rules. Animal care

regulations.

3 Blood I.

4 Blood I.

5 Blood II.

6 Blood II.

7 Blood III.

8 Blood III.

9 Seminar: Blood (Discussion of the topics covered by the lectures and student labs)

10 Test on the chapter

11 The heart and circulation I.

12 The heart and circulation I.

13 The heart and circulation II.

14 The heart and circulation II.

15 The heart and circulation III.

16 The heart and circulation III.

17 The heart and circulation IV.

18 The heart and circulation IV.

19 Seminar: The heart and circulation

20 Test on the chapter

21 Respiration

22 Respiration

23 Gastrointestinal tract

24 Gastrointestinal tract

25 Examination of the urine

26 Examination of the urine

27 Measurement of the actual metabolic rate in human

28 Measurement of the actual metabolic rate in human. Test on the chapters.

Seminars


Topics of questions for the theoretical examination

1. Describe the body fluid compartments and explain the methods used for measurement of body fluid volumes

2. Describe the major plasma proteins and the other non-electrolytic constituents of blood and explain their function in the body

3. Describe the intra- and extracellular ionic components and explain their physiological functions

4. The structure, function and origin of erythrocytes

5. Characterize the various leukocytes indicating their origins and functions

6. Origin and function of blood platelets

7. The basic structure and metabolism of haemoglobin and the metabolism of iron

8. Describe the two pathways involved in the initiation of blood coagulation


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9. Specific mechanism of clot formation

10. Describe the mechanism of fibrinolysis. Explain the significance of anticlotting mechanism

11. Regulation of H+ ion concentration in the blood

12. A-B-0 blood groups. The Rh blood types

13. The role of leukocytes in the defence mechanism

14. Mechanical activity of the heart and the three-component model of heart muscle. Calcium ion movements within the cardiac muscle cell

15. Generators and conductors of impulses in the heart. Refractory periods

16. The sequence of events in the cardiac cycle

17. The human electrocardiogram (ECG). Electrocardiography: bipolar and unipolar leads

18. The heart sounds. Phonocardiography (PCG)

19. Cardiac output: measurement, normal standards and physiological variations

20. Metabolism and energetics of cardiac muscle

21. Ventricular wall tension and the Laplace relationship

22. The heart-lung preparation (Starling`s laws)

23. Arterial blood pressure: determinants of normal arterial blood pressure

24. The arterial and the venous pulse. Basic principles of hemodynamics.

25. Circulation through the capillaries

26. The properties, production and the movement of lymph

27. Circulation in the vein. Effect of gravity on circulation

28. The pulmonary circulation. Control of lung vessels

29. The coronary circulation

30. Cerebral circulation. The concept of blood-brain barrier.

31. Splanchnic circulation

32. Skeletal muscle circulation. Cutaneous circulation

33. Nervous control of the heart

34. Control mechanisms of the circulatory system: general considerations

35. Local control of the vascular smooth muscle

36. Autoregulation of blood flow in tissues and organs

37. The function and importance of baroreceptors in the regulation of circulation

38. Reflex control mechanisms of circulation

39. Mechanisms of vasoconstriction and vasodilatation

40. Mechanics of respiration (functions of respiratory muscles, compliance, intrathoracic pressures, respiratory volumes)

41. Alveolar air, alveolar ventilation, dead spaces. Function of the respiratory passageways

42. Gaseous exchange in the lungs and tissues

43. O2 and CO2 transport in the body

44. Peripheral and central regulatory mechanisms of respiration. Respiratory reflexes

45. Chemical control of respiration. Acidosis, alkalosis

46. Different types of hypoxia. Oxygen treatment. Mechanisms of acclimatisation. Nitrogen narcosis. Decompression sickness

47. Describe the origin, composition, function and control of salivary secretion

48. Describe the origin, nature and function of gastric secretion indicating the mechanisms of regulation

49. Mechanism and regulation of gastrointestinal movements

50. Identify the pancreatic secretions, their components, their action and the substrates on which they act. Control mechanism of pancreatic secretion

51. Describe the basic ingredients and functions of the bile indicating the origin and fate of the components and the factors controlling

bile secretions and gall bladder functions

52. Identify the components and functions of the intestinal system

53. Describe how carbohydrate is digested and absorbed indicating the enzymes involved

54. Describe how fat is digested and absorbed indicating the enzymes and secretions involved

55. Describe how protein is digested and absorbed indicating the enzymes and secretions involved

56. Dynamics of glomerular filtration. Glomerular filtration rate. Plasma clearance

57. Renal blood flow. Clearance of PAH. Extraction ratio. Filtration fraction

58. Regulation of renal blood flow and pressure. Renin-angiotensin system

59. Reabsorption and secretion of different substances in the renal tubule. Methods for their investigation

60. Concentrating and diluting mechanisms of the kidney

61. Fluid volume regulation of the body

62. Regulation of concentrations of ions in the extracellular fluid. Regulation of osmolality of body fluids

63. Basal metabolic rate. Describe factors influencing the basal metabolism

64. Define metabolic rate explaining those factors influencing the total expenditure of energy by the body

65. Describe the necessary elements of normal diet


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66. The normal body temperature and its physiological variations. Hyperthermia, fever, hypothermia

67. Chemical regulation of body temperature, changes of regulation at low and high environmental temperature

68. Physical regulation of body temperature, changes of regulation at low and high environmental temperature

69. Central regulatory mechanisms of heat production and heat loss

70. Mechanisms of hormone action (receptors, intracellular mediators, cAMP, Ca2+ and diacylglycerol, protein kinases)

71. Mechanism of hormonal regulation. Negative and positive feedback controls in the endocrine system

72. The anterior pituitary hormones. Regulation of pituitary hormone secretions. Pituitary dysfunction

73. Function of growth hormone during development and after adolescence

74. Abnormalities of thyroid secretion. Goitrogens

75. Function of the thyroid gland. Iodine metabolism in the body

76. Hormonal changes during menstrual cycle

77. Hormonal changes during pregnancy. Role of placenta in pregnancy. Foeto-placental unit

78. Hormones of lactation

79. Mechanism of erection and ejaculation. The sexual act (coitus)

80. The function of testis, epididymis, seminal vesicle and prostate

81. Regulation of the sexual behaviour. Maternal behaviour

82. Physiological changes at puberty and climacteric

83. Vasopressin and oxytocin. Function of ANH (atrionatriuretic hormone)

84. The effects of prostaglandins

Questions for the student lab report:

1. Hematocrit

2. Red blood cell counting

3. White blood cell counting

4. Differential leukocyte count

5. Determination of osmotic resistance.

6. Determination of hemoglobin concentration

7. MCV, MCH, MCHC values

8. Prothrombin time

9. Blood group determination (AB0 and Rh typing)

10. Examination of hemoglobin spectra

11. How to use work stations for electrophysiological registrations

12. Recording of heart beats of the frog „in situ”

13. Electric stimulation of heart (demonstr. of extrasystole)

14. Effect of thermal stimulations of frog’s heart.

15. Ligatures of Stannius

16. Investigation of Bowditch’s „All or nothing” law

17. Investigation of summation

18. Electrocardiography (ECG)

19. Examination of the arterial pulse

20. Measurement of blood pressure in human

21. Isolated frog’s heart preparing by Straub cannulla

22. Effect of acethylcholin on isolated frog’s heart

23. Effect of adrenalin on isolated frog’s heart

24. Effect of ions on the isolated heart

25. Direct measurement of blood pressure in cat

26. The circulation through capillaries of frog’s tongue.

27. Pulse wave registration.

28. Spirometry, dynamic parameters of respiration

29. Volumes and capacities of the lungs.

30. Measurement of maximal respiratory pressures (The experiments of Müller and Valsalva)

31. Demonstration of basic respiratory movements and pressure/volume changes (Donders model)

32. Gastric juice: Determination of BAO, MAO, PAO

33. Bile: detection of bile pigments

34. Feces: Detection of blood (Guajac-, benzidin-, Hematest)

35. Measurement of the actual metabolic rate in human

36. Measurement of the oxigen consumption in rat.

37. Specific gravity of urine.

38. Examination of the urine sediment


18

39. Urine examination with reagent strip methodology

40. Examination of pathological urine components with tests in tubes: protein, glucose, keton bodies, blood, ubg, bilirubin, pus detections

Participants

Kovács Anita (KOAMAET.PTE)


19

OPO-GN1 PHARMACOBOTANY 1

Course director: DR. ÁGNES FARKAS, associate professor

Department of Pharmacognosy



Course headcount limitations (min.-max.): 3 – 60 Prerequisites: OPR-LAT completed

Topic

Pharmacobotany covers all pharmaceutical aspects of botany, including cytology, histology, morphology and taxonomy of plants. Plant

systematics discusses the geographical origin of plant species, the possibilities of their cultivation and protection. A special emphasis is

laid on chemotaxonomic aspects, since the medicinal effect of a plant is often related to its taxonomic classification and chemical

characteristics. Practical instruction focuses on the knowledge of medicinal plants, including the confident use of plant identification

keys. Based on their knowledge of histology students are required to apply proper anatomical terms, and finally identify plant species

(taxa). The thorough knowledge of both general and specific pharmacobotany is a prerequisite of studying pharmacognosy.



Mid-term exams

Students have to pass (min. 60%) two written exams based on lecture materials, and another two written exams based on the practice

materials. The exams will be held on the 7th and 13th week of the semester.

For each test, maximum two other chances (B and C chance) will be offered for students who do not pass the exam at the first occasion

(A chance).

Students have to take notes and prepare drawings based on microscopic examinations. Students have to show their lab notebook to the

practice leader, who acknowledges fulfilment of the practice by his/her signature.


Participation is compulsory in lab practices; up to 2 absences are allowed. Missed practices can be made up either by joining the other

groups or taking extra time at the following lab practice. In all cases, students must make arrangements with their lab instructors in

advance.

Reading material


Á. Farkas: Pharmacobotany 1, University of Pécs, Institute of Pharmacognosy, Pécs, 2010

N. Papp: Pharmacobotany Practices, University of Pécs, Institute of Pharmacognosy, Pécs, 2011


Farkas Á., Papp N., Bencsik T., Horváth Gy.: Digital Herbarium and Drug Atlas, electronic learning material, 2014 TÁMOP-4.1.2.A/1-11/1-2011-0016

- Notes


D.F. Cutler, T. Botha, D.W. Stevenson: Plant Anatomy. An Applied Approach, Wiley-Blackwell, 2008

R.F. Evert, S.E. Eichhorn: Esau’s Plant Anatomy: Meristems, Cells and Tissues of the Plant Body: Their Structure, Function and Development, 3rd edition, Wiley

A. Fahn: Plant Anatomy, 4th edition

Lectures

1 Structure of the plant cell. Plastids and inclusions.

Dr. Papp Nóra

2 Structure of the cell wall.

Dr. Papp Nóra

3 Plant tissues I. Meristematic tissues.

Dr. Papp Nóra

4 Plant tissues II. Epidermal tissue; stomata, trichomes, secondary epidermis.

Dr. Papp Nóra

5 Plant tissues III. Vascular tissues; vascular bundle types.

Dr. Papp Nóra

6 Plant tissues IV. Ground tissues: parenchyma, collenchyma, sclerenchyma, secretory tissues.

Dr. Papp Nóra


20

7 1st written test

Dr. Papp Nóra

8 Root morphology. Modified roots. Root anatomy

Dr. Papp Nóra

9 Shoot morphology and anatomy. Shoot types.

Dr. Papp Nóra

10 Leaf morphology and anatomy. Leaf arrangement (phyllotaxis). Leaf venation.

Dr. Papp Nóra

11 Flower morphology. Inflorescence types.

Dr. Papp Nóra

12 Fertilisation, embryogenesis, ovule and seed. Fruit types.

Dr. Papp Nóra

13 2nd written test

Dr. Papp Nóra

14 Taxonomic categories, chemotaxonomic relations, rules of nomenclature.

Dr. Papp Nóra

Practices

1 Microscopic techniques and preparations (leaf clearing, cross sections, epidermal tissues). Plastids of the plant cell. Inclusions and crystals.

2 Chemical substances of the cell wall (cellulose, lignin). Mucilage content of the cell wall and the cytoplasm. Investigation of vacuolar content (inulin, alkaloids, tannins, anthocyanins).

3 The root and shoot tip; meristematic tissues.

4 Leaf epidermis; cross sections and cleared preparations.

5 Microscopic study of stem cross sections: vascular tissues and mechanical tissues.

6 Ground tissues. Plant secretory systems (schizogenous, lysigenous cavities, laticifers, glandular trichomes, glandular scales, nectaries).

7 Perianth, androecium, gynoecium. Tissue structure of the fruit and seed.

8 Morphological analysis of the root and its modifications.

9 Shoot system types, shoot modifications.

10 Leaf types, leaf arrangement, parts of the leaf. Shape, margin and venation of leaves, leaf modifications.

11 Morphological analysis of the flower: perianth, androecium, gynoecium. Floral formula, floral diagram.

12 Morphological investigation of inflorescences.

13 Fruit morphology: Dry dehiscent and indehiscent fruits.

14 Fruit morphology: Fleshy fruits, compound fruits and false fruits.

Seminars


The grades of the 2 written lecture tests serve as the basis of the final course grade.

The grades of the 2 written practical tests and the lab notebook serve as the basis of the practical grade.

Participants

Dr. Papp Nóra (PANAAA.T.JPTE)


21

OPA-G1B PHARMACEUTICAL BIOCHEMISTRY 1

Course director: DR. KATALIN SIPOS, associate professor

Department of Forensic Medicine

3 credit ▪ semester exam ▪ Basic module ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 5 – Prerequisites: OPA-AN1 completed + OPA-AT1 completed

Topic

The two-semester biochemistry course provides the essential fundamental biochemistry knowledge for the pharmaceutical students. This

course deals with the metabolic pathways of the living cell: the reactions, steps and regulation of these pathways. In the first semester

students will be introduced to the life of the basic synthetic and anabolic biochemical pathways and they will study how energy is produced in the cell. We will pay special attention to enzymes: their features, regulations, roles in the drug metabolism and action.



Mid-term exams

There are two mid-term exams. The results of them is included in the result of the exam.


According to personal agreement

Reading material



The materials of the lectures and seminars will appear on Neptune.

- Notes

The e-notes of Biochemistry will appear on Neptune.


Ch. P. Woodbury: Biochemistry for the Pharmaceutical Sciences

Raymond S. Ochs: Biochemistry

Thomas M. Devlin: Textbook of Biochemistry with Clinical Correlations

Lectures

1 Introduction

Dr. Sipos Katalin

2 Thermodynamics, biochemical reactions

Dr. Sipos Katalin

3 Biomembranes. Transport processes I

Dr. Sipos Katalin

4 Transport processes II

Dr. Sipos Katalin

5 Enzymes: characteristics, types, catalytic activities

Dr. Sipos Katalin

6 Proteases

Dr. Pandur Edina

7 Basic regulatory mechanisms in metabolism

Dr. Sipos Katalin

8 Glycolysis

Dr. Farkas Viktória

9 Gluconeogenesis


10 Glycogen metabolism


11 Cori cycle



22

12 Pentose phosphate pathway


13 Metabolism of complex carbohydrates

Dr. Sipos Katalin

14 Pyruvate dehydrogenase complex


15 Citric acid cycle


16 Mitochondrial transport processes


17 Terminal oxidation, ATP synthesis I


18 Terminal oxidation, ATP synthesis II


19 Degradation of lipids

Dr. Sipos Katalin

20 Ketone bodies


21 Biosynthesis of fatty acids


22 Biosynthesis of complex lipids

Dr. Sipos Katalin

23 Cholesterol metabolism I


24 Cholesterol metabolism II


25 Characterization of amino acids


26 Nucleic acids: building blocks, structures


27 Preparation for exam

Dr. Sipos Katalin


Dr. Sipos Katalin

Practices

Seminars

1 Macromolecules in biochemistry

2 Nutrition and vitamins in biochemistry

3 Carbohydrates: biochemical characterization. Carbohydrates in the extracellular space

4 Clinical importance of carbohydrates

5 Regulation of enzymes

6 Enzymekinetics. Inhibition of enzymes

7 Structure, folding and degradation of proteins

8 Lipids: phospholipids, sphingolipids, cholesterol, fatty acids

9 Clinical importance of lipids

10 Clinical consequences of terminal oxidation.

11 Carbohydrate metabolism

12 Lipid metabolism

13 Enzyme inhibiting drugs



There are no given exam questions. The topics of the exam will be the materials of lectures and seminars.

Participants

Dr. Farkas Viktória (FAVSAAP.PTE), Dr. Sipos Katalin (SIKMAAO.PTE), Dr. Takátsy Anikó (TAAAAA.T.JPTE)


23

OPA-MAN INSTRUMENTAL ANALYSIS

Course director: DR. FERENC KILÁR, professor

Institute of Bioanalysis

5 credit ▪ semester exam ▪ Basic module ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 1 – Prerequisites: OPA-AN2 completed

Topic

The theory and practice of instrumental analysis.



Mid-term exams

Lectures. Two written tests (7th and 13th weeks) during the semester.

Practices. Each practice is preceded with a short written test, and the students should prepare a report of the measurements and the

evaluation. A final grade will be given for the practices, if 75 % of the practices are completed successfully. The final grade must be

„satisfactory” at least.

The final mark for the Instrumental analysis is given by an oral exam, and by considering the grade of the practices. Failure in the practice

concludes the failure of the subject.


Maximum one absence can be retaken, in selected practices.

Reading material



Material can be downloaded from the website of the Institute of Bioanalysis under the Educational materials link:

http://aok.pte.hu/en/egyseg/oktatas/160 (the username and password are provided in the lectures).

- Notes


D.A. Skoog, F.J. Holler, S.R. Crouch: Principles of Instrumental Analysis (Thomson)

D.G. Watson: Pharmaceutical Analysis (Elsevier)

Lectures

1 Basis of creating instrumental signals

Dr. Kilár Ferenc

2 Errors in instrumental analysis, signal collection

Dr. Kilár Ferenc

3 Basic chemometry

Dr. Kilár Ferenc

4 Electroanalysis (potentiometry, conductometry, voltammetry)

Dr. Kilár Ferenc

5 Spectrophotometry

Dr. Kilár Ferenc

6 Spectrophotometry

Dr. Kilár Ferenc

7 Infrared spectroscopy, fluorescence spectroscopy

Dr. Kilár Ferenc

8 Infrared spectroscopy, fluorescence spectroscopy

Dr. Kilár Ferenc

9 Liquid chromatography, HPLC

Dr. Felinger Attila

10 Liquid chromatography, HPLC

Dr. Felinger Attila

11 Gas-chromatography

Dr. Poór Viktória

http://aok.pte.hu/en/egyseg/oktatas/160


24


Dr. Poór Viktória

13 Electrokinetic methods, electrophoresis

Dr. Kilár Ferenc

14 Electrokinetic methods, electrophoresis

Páger Csilla

15 Atomic absorption spectrometry

Dr. Kilár Ferenc


Dr. Kilár Ferenc

17 Nuclear magnetic resonance spectrometry

Dr. Kilár Ferenc

18 Nuclear magnetic resonance spectrometry

Dr. Kilár Ferenc

19 Electron paramagnetic resonance spectrometry

Dr. Kilár Ferenc

20 Electron paramagnetic resonance spectrometry

Dr. Kilár Ferenc

21 Mass spectrometry

Dr. Kilár Ferenc


Dr. Kilár Ferenc

23 Analytical ultracentrifugation

Dr. Kilár Ferenc

24 Analytical ultracentrifugation

Dr. Kilár Ferenc

25 Mössbauer spectroscopy

Dr. Kilár Ferenc

26 ORD, CD, polarimetry

Dr. Kilár Ferenc

27 Thermal analysis

Dr. Kilár Ferenc

28 Thermal analysis

Dr. Kilár Ferenc

Practices

1 Potentiometry

2 Potentiometry

3 Potentiometry

4 Potentiometry

5 Potentiometry

6 Potentiometry

7 Conductometry

8 Conductometry

9 Conductometry

10 Spectrophotometry













25

22 HPLC

23 HPLC

24 HPLC

25 Capillary electrophoresis



28 Infrared spectrometry



31 NMR

32 NMR

33 NMR







40 Retake of missing practices



Seminars


Exam topics can be found in the website of the Institute of Bioanalysis under the

Education link: http://aok.pte.hu/en/egyseg/oktatas/160

Participants

Dr. Bufa Anita (BUAEAA.T.JPTE), Dr. Dergez Tímea (DETCAA.T.JPTE), Dr. Poór Viktória (POVAAA.T.JPTE), Makszin Lilla (MALHAAT.PTE), Nagy Laura (NALPACT.PTE), Páger Csilla (PACMAAO.PTE)

http://aok.pte.hu/en/egyseg/oktatas/160


26

OPA-SK2 ORGANIC CHEMISTRY 2

Course director: DR. KÁLMÁN HIDEG, professor emeritus

Department of Organic and Pharmacological Chemistry

6 credit ▪ final exam ▪ Basic module ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 2 – 60 Prerequisites: OPA-SV1 completed

Topic

This subject is a part of chemistry basics. Its aim to present the nomenclature, structure, physical and chemical properties, synthesis, reaction mechanisms and application of organic compounds.


During the semester students have to accomplish the preparative works and written tests. They have to document the experiments in their

exercise book. The organic chemistry laboratory course will be graded (1-5), based on the two written tests on 6th and 11th week, first of

all. The evaluation can be modified by grades of semi-micro preparations, success of unknown identification as well as the outlook of

the records of exercise book.

Mid-term exams

Students have two extra dates to accomplish the written tests of laboratory course.


Students have to contact their lab TA within 48 hours of missing lab to make the necessary arrangements.

Reading material


John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th ed., Thomson Brooks, Belmont, 2007.


Kálai, T, Bognár, B. Organic Chemistry Laboratory Manual, Dept. of Org. Med. Chem., Medical Faculty, University of Pécs, 2010.

- Notes


T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.

William H. Brown: Organic Chemistry, Saunders College Publishing, Fort Worth, 1995.

Charles F. Wilcox, Jr., Mary F. Wilcox: Experimental Organic Chemistry: a Small-scale Approach, 2nd ed., Prentice-Hall, London, 1995.

Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory with Multistep and Multiscale Syntheses, 3rd ed., Wiley, New York, 1994.

Lectures

1 Aldehydes and ketones; structure, physical, chemical properties, reactions, important representatives.






4 Carboxylic acids and their derivatives - structure, physical, chemical properties.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

7 alpha-Position substituted derivatives of carboxylic acids.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán


27

10 Di- and polycarboxylic acids, representatives.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

13 Carbonic acid derivatives and their importance in biology and drugs.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

16 Esters of inorganic acids, biological significance (phosphatides, phospholipids).

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

19 alpha-Amino acids, peptides and proteins, biological importance.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

22 Monosaccharides; structure, mutarotation, reactions and biological importance.






25 Di- and polysaccharides; food reserve and structural material polysaccharides.






28 Heterocycles (5- and 6-membered heteroaromatic compounds, structure, biologically important representatives, chemical mode of action of coenzymes).

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás

34 Heterocycles in nucleotides, nucleosides, nucleic acids.

Dr. Kálai Tamás


Dr. Kálai Tamás


Dr. Kálai Tamás


28

37 Vitamins.

Dr. Hideg Kálmán

38 Vitamins.

Dr. Hideg Kálmán

39 Vitamins.

Dr. Hideg Kálmán

40 The basics of spectrometric identification of organic compounds.

Dr. Hideg Kálmán


Dr. Hideg Kálmán


Dr. Hideg Kálmán

Practices

1 General instructions for work in the laboratory, safety precautions; Purification of benzaldehyde, synthesis of benzoin.



4 Synthesis of 2,6-dibenzylidene-cyclohexanone; Characteristic tube reactions of oxo compounds.



7 Synthesis of benzil; Identification of 4th unknown compound.



10 Characteristic tube reactions of carbohydrates; Preparation of oxalic acid, isolation of citric acid and pectin.



13 Acetylation of glucose; Identification of 5th unknown compound;



16 1st written test; Characteristic tube reactions of carboxylic acids; Synthesis of aspirin.



19 Synthesis of lidocain (1st step); Characteristic tube reactions of carboxylic acid derivatives



22 Synthesis of lidocain (2nd step)



25 Synthesis of heterocycles I.: benzimidazole, 4,5-diphenyl-imidazole; Characteristic tube reactions of heterocycles

26 Synthesis of heterocycles I: benzimidazole, 4,5-diphenyl-imidazole; Characteristic tube reactions of heterocycles

27 Synthesis of heterocycles I: benzimidazole, 4,5-diphenyl-imidazole; Characteristic tube reactions of heterocycles

28 Synthesis of heterocycles II: dilantin, 4-methyl-7-hydroxycoumarine



31 2nd written test. Isolation of caffeine



34 Isolation of quercetin and myristic acid



37 Characteristic tube reactions of amino acids and peptides



40 Evaluation

41 Evaluation

42 Evaluation


29

Seminars


1. Alkanes - Orbital hybridization and the structure of alkanes; Nomenclature, physical and chemical properties, combustion, free radical

chlorination, conformation, cycloalkanes, type of ring strains, demonstrate with examples.

2. Unsaturated hydrocarbons - sp2 and sp hybridization, nomenclature, physical properties, reactions and synthesis of alkenes and alkynes. Electrophilic addition, Markovnikov’s rule, 1,2- and 1,4-addition, conjugated and cumulated dienes.

3. Importance of unsaturated hydrocarbons in industry and biology - polymerization, isoprene, terpenes, steroids, carotenoids, polymers, rubber

4. Aromatic compounds - the structure of benzene, Hückel’s rule. Electrophilic aromatic substitution reactions. (Nitation, sulfonation,

bromination, Friedel-Crafts reactions), direction rules, classification of substituents, polyaromatics: examples, their chemical reactions aromatic electophilic substitution, oxidation.

5. Alkyl halides - the character of C-X bonds, physical properties, reactivity of alkyl halides, synthesis of alkyl and aromatic halides, and reactions of alkyl halides (substitution, elimination); Organic halides in the environment.

6. Organometallic compounds - their structure, their importance in organic syntheses (Mg, Na, Li, Si, Cu, Cd compounds).

7. Alcohols, phenols, ethers - Structure, physical and chemical properties, reactions; Their biological importance.

8. Stereochemistry: isomerism, absolute and relative configuration, chirality, racemates, diastereomers, polarimetry, resolution.

9. Sulfur containing compounds - Physical, chemical properties, importance in biological processes (in amino acids, peptides, methylation in biology, AcCo-A, drugs, sulfonamides, penicillin, cefalosporin).

10. Nitro compounds - electronic structure, physical, chemical properties, synthesis (including aromatic electrophilic nitration), reduction

of nitro compounds, their nitro-aldol reaction, biologically important nitro compounds (glycerine trinitrate, chloroamphenicol).

11. Amino compounds - Physical, chemical properties, basicity of amines (compare aniline, ammonia, methylamine, dimethylamine etc.)

their possible synthesis (alkylation of ammonia, Gabriel synthesis, reductive amination, Hofmann rearrangement), reactions: Hinsberg reaction, oxidation of amines, reaction with HNO2.

12. Biologically important amines: structure and properties of histamine, tryptamine, choline, acetylcholine, taurine, putrescine, adrenaline; Alkaloids: definition (structure of mescaline, nicotine, coniine, quinine, papaverine, morphine)

13. Aldehydes and ketones: electronic structure of carbonyl group, enol-oxo tautomerism, physical, chemical properties, synthesis of

aldehydes and ketones, their reaction: aldol condensation, Canizzaro-reaction, Silver mirror/Fehling test, oxidation, reaction with amines, hydrazines, Grignard-reagent, oximes, Beckmann-rearrangement, ketenes, quinones, vitamin K.

14. Carbohydrates: classification of carbohydrates (ketose, aldose, pyranose, furanose, pentose, hexose), hemiacetal formation,

mutarotation, D- and L-sugars - and -anomers. Chemical-physical properties of carbohydrates. The following

covalent structures are required: glucose, fructose, mannose, galactose, ribose, 2-deoxy-ribose, glyceraldehyde, ascorbic acid.

Oxidation of carbohydrates, acetylation, bromination, formation of O- and N-glycosides. Epimerization (glucose, mannose, fructose). Formation of fructose 1,6-diphosphate in aldol reaction.

15. Function and structure of oligosaccharides and polysaccharides: sucrose, maltose, cellobiose, lactose, kitine, pectine, cellulose, starch.

Reducing sugars and non-reducing sugars, the invert sugar. Chemical reactions of oligosaccharides.

16. Carboxylic acids and their derivatives (acyl chlorides, anhydrides, esters, amides): Electronic structure of carboxylic acids and their

derivatives. Formation of carboxylic acids and their derivatives. Reactivity of carboxylic acid derivatives, acidity of carboxylic acids.

Physical and chemical properties of carboxylic acids. Ester synthesis, Claisen-condensation. Most important carboxylic acids: formic acid, acetic acid, benzoic acid, oleic acid, linolic and linoleic acid, palmitic and stearic acids, structure of lipids and phospholipids.

17. Alpha-substituted carboxylic acids and carbonic acid: halogenation, lactic acid, pyruvic acid, malonic acid, malonic acid synthesis,

oxalic acid, malic acid, maleic acid, fumaric acid, citric acid. Their structure, acidity, biological importance. Carbonic acid

derivatives: carbonic acid and its esters, phosgene, chloroformic acid esters and their utilization in amino acid synthesis, urea,

thiourea, diureides, barbituric acid and its derivatives, guanidine, creatine.

18. Amino acids, peptides: the exact covalent structure of 20 amino acids, physical and chemical properties (zwitterion formation,

chirality) peptide link formation, amino acid synthesis, glutathione, peptide synthesis, structure of proteins (primary, secondary,

tertiary, quaternary), general features of proteins, their classification with examples, denaturation and colour-reactions of proteins (Xantoprotein-test, Millon-test etc.)

19. 5-Membered heterocycles: classification of heterocycles, their nomenclature, most important representatives: furane, thiophene,

pyrrole. Heterocycles with two heteroatoms: oxazole, thiazole, imidazole, their electronic structure, aromaticity, aromatic

electrophilic substitution, basicity, virtual tautomerism. Biologically important representatives: biotin, ultraseptil, histamine, penicillins, aminophenazone, furfural; Indole and its derivatives: serotonine, auxins, indigo.

20. 6-Membered heterocycles: their nomenclature, most important representatives: pyridine, quinoline, isoquinoline, pyrilium,

benzpyrilium cation, their basicity, electronic structure, eno-oxo amino-imino tautomerism, aromatic electrophilic substitution,

nucleophilic substitution, biologically important derivatives: rutin, vitamin E, cyanidium chloride, tetrahydrocannabinol,

nicotinamide, quinine, papaverine, vitamin B6, isoniazide, nifedipine, barbituric acid: veronal, sevenal bases of nucleic acids, base

pairs cytosine, guanine, adenine, timine, uracil, their exact covalent structure, structure of DNA, RNA, vitamin B1, purine: caffeine, theophylline, theobromine, xanthine, pteridine, structure and function of folic acid.

21. Vitamins: classification of vitamins, their exact covalent structure, their biological role. Vitamin A, vitamin D, Vitamin E, vitamin

K, Vitamin B1, Vitamin B3, Vitamin B5, the role and function of the NAD, Vitamin B6, Vitamin B7, inosite, p-aminobenzoic acid,

folic acid, Vitamin B12, Vitamin C, Vitamin P and flavonoids, Vitamin U.

Participants

Dr. Bognár Balázs (BOBGAAT.PTE)


30

OPG-GI1 BASIC PRINCIPLES OF PHARMACY

Course director: DR. LAJOS BOTZ, professor

Department of Pharmaceutics and University Pharmacy

2 credit ▪ midsemester grade ▪ Pharmaceutical science theoretical knowledge and practical skills module ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPO-MB2/OPO-GB2 completed

Topic

The basic aims of the course are to provide fundamental knowledge of pharmaceutics and gain insight into the pharmaceutical profession.

The subject will support further studies and the summer professional practice by improving vocabulary, professional knowledge, etc..

Further goals are to draw the attention of students towards specific topics (professionalism, roles of pharmacists in healthcare) of pharmacy, to help students gain interest in practical aspects of pharmaceutical work and to introduce further professional studies.

The course gives an overview of the basic principles of pharmacy and pharmaceuticals. Definitions of the different groups of

pharmaceuticals, synopsis of the process of drug development, evolution and role of pharmacopoeias, sites and aims of small-, medium-

and large scale drug manufacturing, the role of community and clinical pharmacies. During the semester several on-site visits will be organized to familiarize students with the different fields of pharmacists.

Attendance of, and active participation in the lectures, furthermore understanding of given topics are the basic requirements of completing

the course. Students shall hold a short presentation regarding a previously discussed topic and shall take attend the on site visits organized

by the Institute (community pharmacy, clinical and hospital pharmacy, pharmaceutical industry). Topics discussed during the lectures,

but not included in the notes/books will also be included in the exams. Students can access the slides of the lectures and further reading material on a designated web based interface (Neptun Meet Street). Prior knowledge from earlier theoretical studies is an advantage.


Acceptance of term/semester (requirements of registration for the exam):

- Regular attendance of classes/lectures (maximum 25 % of absence is accepted),

- Assignments given in class should be carried out during term-time and,

- The mid-term and end-of-the-term test(s) should be passed (60,1%, minimum grade 2).

End-of-semester grade is given by end-of-the-term test’s result, any tests written throughout the semester and student performance during

the semester.

Examination and granting of grades: for Basic Principles of Pharmacy grade (midterm grade) is given based on mid-term and end-of-

the-term test results.

Mid-term exams


Compensation is possible following personal discussion.

Reading material



- Notes


Christopher A Langley, Dawn Belcher: Applied Pharmaceutical Practice, 2nd edition, Pharmaceutical Press 2012

Medicines, Ethics and Practice: The Professional Guide for Pharmacists, 36th edition, Royal Pharmaceutical Society of Great Britain, 2012

Lectures

1 Introduction to Basic Principles of Pharmacy. Short presentation of the Department of Pharmaceutics & Central Clinical Pharmacy

Dr. Fittler András Tamás

2 Pharmacy as a profession. Areas of pharmacy practice


3 Introduction of the product categories found in community pharmacies


4 Routes of administration


5 Classification of medications



31

6 How active substances and medicines are named. Index Nominum


7 Pharmacopoeias and Formularies


8 Contents and format of the medical prescription


9 Handling of the prescription by the pharmacist: Pharmacy Practice Procedures


10 Labelling of dispensed medicines


11 Latin terms and abbreviations, pharmaceutical calculations


12 On site visit to the Central Clinical Pharmacy

Dr. Lankó Erzsébet

13 Getting familiar with ingredients and dosage forms of pharmaceuticals made in pharmacies

Dr. Mayer Anna

14 Manufacturing of medicines and the importance of good manufacturing practice


15 Structure and tasks of a community pharmacy


16 Structure and tasks of a community pharmacy. On site visit


17 Structure and tasks of a clinical pharmacy


18 Structure and tasks of a clinical pharmacy. On site visit


19 Research and development of medicines

Dr. Vida Róbert György

20 Clinical trials

Dr. Vida Róbert György

21 Structure and tasks of the pharmaceutical industry


22 Structure and tasks of the pharmaceutical industry. On site visit


23 Oral presentations of students on pre-arranged topics 1


24 Oral presentations of students on pre-arranged topics 2


25 History of Pharmacy and Medicine (1) from the ancient world to 1100 AD.


26 History of Pharmacy and Medicine (2) in the medieval world form 1100 to 1617 AD.


27 History of Pharmacy and Medicine (3) in the modern world 1841-1986.

Dr. Végh Anna

28 Where are we heading? Pharmacy in the 21st century. Test

Dr. Végh Anna

Practices

Seminars


Based on the topics of the lectures.

Participants


32

OPO-EN2 HUMAN PHYSIOLOGY 2

Course director: DR. ZOLTÁN KARÁDI, professor

Department of Physiology

5 credit ▪ final exam ▪ Pharmaceutical biology and medical theoretical knowledge module ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 1 – 200 Prerequisites: OPO-EL1 completed

Topic

The most important mission of the Physiology Course in medical education is to familiarize students with the attributes of healthy functions of the living organism.

While acquiring knowledge about the most important functional characteristics of the human body the students can rely on their prior studies in biology, biophysics, chemistry-biochemistry and anatomy.

During the semester we introduce the most important elements of functioning of the organs and organ systems, as well as their cooperation

also required to adapting to the environment, and the factors affecting these processes.

Special emphasis is placed on the neural and humoral regulatory processes of these life-functions, which are vital to maintain and preserve the homeostasis of the organism.

With the transfer of all this knowledge we would like to mould a holistic attitude and thinking of students, which will enable them to

better understand the functions of the now healthy, however, later dysfunctional human organism.



Mid-term exams

Written test on the 11th week Friday at 16:00.


The missed lab practice is advised to be covered by joining another group while the same topic is on schedule.

Reading material


J.E. Hall: Guyton and Hall Textbook of Medical Physiology, 12th edition, 2013


Figures of the lectures given are available on the homepage of Institute of Physiology and on the Neptun Meet Street.

Important messages on new information will be announced at the lectures and will be sent to you by course mails.

Please always find the current updated information and study materials on the homepage of the Institute of Physiology (physiology.aok.pte.hu).

- Notes

Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practices 2, internet study material, printable notebook, 2015

Homepage of PTE ÁOK Institute of Physiology: Physiology Lab Practice Worksheets 2, internet study material, printable notebook, 2015


L.S. Costanzo: Physiology, 5th edition, 2014

W.F. Ganong: Review of Medical Physiology, 2012, Appleton and Lange, Lange Medical Publications

Fonyó: Principles of Medical Physiology, Medicina Publishing, 2002

J.B. West (ed.): Best and Taylor’s Physiological Basis of Medical Practice, Williams and Wilkins, 1998

Lectures

1 Endocrinology of the adrenal cortex. I.


2 Endocrinology of the adrenal cortex. II.


3 The adrenal medulla. Endocrinology of stress


4 Hormonal control of calcium homeostasis

Dr. Lengyel Ferenc

5 The endocrine pancreas


6 Hormonal control of intermediary metabolism.



33

7 Special problems of neonatal physiology. Physiology of ageing

Dr. Lengyel Ferenc

8 Ionic mechanism of membrane potential. Action potential and its propagation.

Dr. Buzás Péter

9 Electrophysiology of synapses. Neurochemical basis of neurotransmission. Function of the neuromuscular junction.

Dr. Buzás Péter

10 Molecular mechanism of muscle contraction. Mechanics, energetics and heat production of muscle contraction.


11 Electric characteristics of muscle contraction, muscle tone, fatigue. Contraction of smooth muscle.


12 The motor unit. Peripheral neural mechanism of muscle control.


13 Thalamocortical somatosensory functions. The sensory cortex.

Dr. Buzás Péter

14 General properties of spinal cord reflexes. Integrative functions of the spinal cord.


15 The spinal shock. Decerebrate rigidity.

Dr. Jandó Gábor

16 Postural coordination, Locomotion.

Dr. Jandó Gábor

17 Extrapyramidal system.


18 Physiology of the vestibular system.


19 Cerebellar control of motor functions.


20 Cortical control of motor functions. The pyramidal system.


21 Somaesthetic mechanisms. Somatotopic representations in the sensory systems.

Dr. Buzás Péter

22 Thalamocortical somatosensory functions. The sensory cortex.


23 Optics of vision. Retinal mechanisms.


24 Optics of vision, refractory errors of the eye. Retinal mechanisms.

Dr. Buzás Péter

25 Visual pathways, midbrain mechanism of vision. Central mechanism of vision.

Dr. Buzás Péter

26 Eye movements and their control.

Dr. Buzás Péter

27 Physiology of hearing. Central auditory mechanisms.


28 The chemical senses. Olfaction. Taste.

Dr. Szabó István

29 The autonomic nervous system.


30 Electroencephalography.


31 Neural control mechanism of sleep. Clinical importance of the evoked potential technique.


32 The diencephalon (hypothalamus). Its motor, autonomic and hormonal regulatory functions.

Dr. Ollmann Tamás

33 The concept of drive and motivation. Homeostatic drives.

Dr. Ollmann Tamás

34 Central neural regulation of hunger and thirst. Control of biological rhythms.

Dr. Szabó István

35 The limbic system.



34

36 Monoaminergic systems and their functions.


37 Emotions and their central nervous mechanism.

Dr. Ollmann Tamás

38 Mechanism of learning.


39 Types and disorders of memory functions.


40 Plasticity of the peripheral and central nervous system.

Dr. Varga Csaba

41 Intrinsic cortical mechanism. Functions of the frontal lobe. The parieto-temporal lobe.


42 Cerebral hemisphere dominance. Neurophysiological mechanisms of speech. Speech disorders.


Practices

1 The endocrine pancreas.

2 The endocrine pancreas.

3 Reproduction.

4 Reproduction.

5 Peripheral nervous system I.

6 Peripheral nervous system I.

7 Peripheral nervous system II.

8 Peripheral nervous system II.

9 Seminar: Endocrinology, Peripheral nerve, Membrane potential, Action potential, Synaptic transmission.

10 Student report (test).

11 Experiments on muscles.

12 Experiments on muscles.

13 Electromyography, Examination of fatigue.

14 Electromyography, Examination of fatigue.

15 Examination of reflexes.

16 Examination of reflexes.

17 Central nervous system.

18 Central nervous system.

19 Seminar: Muscle and reflexes.

20 Student report (test).

21 Sensory organs I.

22 Sensory organs I.

23 Sensory organs II.

24 Sensory organs II.

25 Electroencephalography in humans.

26 Electroencephalography in humans.

27 Student lab report.

28 Student lab report.

Seminars


Topics of questions for the theoretical examination

1. Describe the body fluid compartments and explain the methods used for measurement of body fluid volumes

2. Describe the major plasma proteins and the other non-electrolytic constituents of blood and explain their function in the body

3. Describe the intra- and extracellular ionic components and explain their physiological functions

4. The structure, function and origin of erythrocytes

5. Characterize the various leukocytes indicating their origins and functions

6. Origin and function of blood platelets

7. The basic structure and metabolism of haemoglobin and the metabolism of iron

8. Describe the two pathways involved in the initiation of blood coagulation

9. Specific mechanism of clot formation

10. Describe the mechanism of fibrinolysis. Explain the significance of anticlotting mechanism


35

11. Regulation of H+ ion concentration in the blood

12. A-B-0 blood groups. The Rh blood types

13. The role of leukocytes in the defence mechanism

14. Mechanical activity of the heart and the three-component model of heart muscle. Calcium ion movements within the cardiac muscle cell

15. Generators and conductors of impulses in the heart. Refractory periods

16. The sequence of events in the cardiac cycle

17. The human electrocardiogram (ECG). Electrocardiography: bipolar and unipolar leads

18. The heart sounds. Phonocardiography (PCG)

19. Cardiac output: measurement, normal standards and physiological variations

20. Metabolism and energetics of cardiac muscle

21. Ventricular wall tension and the Laplace relationship

22. The heart-lung preparation (Starling’s laws)

23. Arterial blood pressure: determinants of normal arterial blood pressure

24. The arterial and the venous pulse. Basic principles of hemodynamics.

25. Circulation through the capillaries

26. The properties, production and the movement of lymph

27. Circulation in the vein. Effect of gravity on circulation

28. The pulmonary circulation. Control of lung vessels

29. The coronary circulation

30. Cerebral circulation. The concept of blood-brain barrier

31. Splanchnic circulation

32. Skeletal muscle circulation. Cutaneous circulation

33. Nervous control of the heart

34. Control mechanisms of the circulatory system: general considerations

35. Local control of the vascular smooth muscle

36. Autoregulation of blood flow in tissues and organs

37. The function and importance of baroreceptors in the regulation of circulation

38. Reflex control mechanisms of circulation

39. Mechanisms of vasoconstriction and vasodilatation

40. Mechanics of respiration (functions of respiratory muscles, compliance, intrathoracic pressures, respiratory volumes)

41. Alveolar air, alveolar ventilation, dead spaces. Function of the respiratory passageways

42. Gaseous exchange in the lungs and tissues

43. O2 and CO2 transport in the body

44. Peripheral and central regulatory mechanisms of respiration. Respiratory reflexes

45. Chemical control of respiration. Acidosis, alkalosis

46. Different types of hypoxia. Oxygen treatment. Mechanisms of acclimatisation. Nitrogen narcosis. Decompression sickness

47. Describe the origin, composition, function and control of salivary secretion

48. Describe the origin, nature and function of gastric secretion indicating the mechanisms of regulation

49. Mechanism and regulation of gastrointestinal movements

50. Identify the pancreatic secretions, their components, their action and the substrates on which they act. Control mechanism of

pancreatic secretion

51. Describe the basic ingredients and functions of the bile indicating the origin and fate of the components and the factors controlling bile secretions and gall bladder functions

52. Identify the components and functions of the intestinal system

53. Describe how carbohydrate is digested and absorbed indicating the enzymes involved

54. Describe how fat is digested and absorbed indicating the enzymes and secretions involved

55. Describe how protein is digested and absorbed indicating the enzymes and secretions involved

56. Dynamics of glomerular filtration. Glomerular filtration rate. Plasma clearance

57. Renal blood flow. Clearance of PAH. Extraction ratio. Filtration fraction

58. Regulation of renal blood flow and pressure. Renin-angiotensin system

59. Reabsorption and secretion of different substances in the renal tubule. Methods for their investigation

60. Concentrating and diluting mechanisms of the kidney

61. Fluid volume regulation of the body

62. Regulation of concentrations of ions in the extracellular fluid. Regulation of osmolality of body fluids

63. Basal metabolic rate. Describe factors influencing the basal metabolism

64. Define metabolic rate explaining those factors influencing the total expenditure of energy by the body

65. Describe the necessary elements of normal diet

66. The normal body temperature and its physiological variations. Hyperthermia, fever, hypothermia

67. Chemical regulation of body temperature, changes of regulation at low and high environmental temperature


36

68. Physical regulation of body temperature, changes of regulation at low and high environmental temperature

69. Central regulatory mechanisms of heat production and heat loss

70. Mechanisms of hormone action (receptors, intracellular mediators, cAMP, Ca2+ and diacylglycerol, protein kinases)

71. Mechanism of hormonal regulation. Negative and positive feedback controls in the endocrine system

72. The anterior pituitary hormones. Regulation of pituitary hormone secretions. Pituitary dysfunction

73. Function of growth hormone during development and after adolescence

74. Abnormalities of thyroid secretion. Goitrogens

75. Function of the thyroid gland. Iodine metabolism in the body

76. Hormonal changes during menstrual cycle

77. Hormonal changes during pregnancy. Role of placenta in pregnancy. Foeto-placental unit

78. Hormones of lactation

79. Mechanism of erection and ejaculation. The sexual act (coitus)

80. The function of testis, epididymis, seminal vesicle and prostate

81. Regulation of the sexual behaviour. Maternal behaviour

82. Physiological changes at puberty and climacteric

83. Vasopressin and oxytocin. Function of ANH (atrionatriuretic hormone)

84. The effects of prostaglandins

85. The endocrine pancreas

86. Function of insulin in the body. Diabetes mellitus

87. Hormonal control of carbohydrate metabolism

88. Hormonal control of calcium and phosphor homeostasis

89. Hormonal function of the adrenocortical system. Hypophyseal regulation of the adrenocortical system. Stress and the adaptation syndrome

90. Function and regulation of mineralocorticoids

91. Function and regulation of glucocorticoids

92. Consequences of hypo- and hyperfunction of the adrenal cortex. Androgens and oestrogens of the adrenal cortex.

93. Hormones of the adrenal medulla. Importance of the sympathoadrenal system

94. Physiology of ontogenesis and ageing.

95. Molecular mechanism of muscle contraction. The regulatory role of calcium ion

96. Mechanical characteristics of muscle. Differentiation of fast and slow twitch muscle fibres. Role of the connective tissue in the function of muscles

97. Mechanism of fatigue

98. Electromyography (EMG)

99. The source of energy for muscle contraction (aerobe and anaerobe processes). Heat production during contraction-relaxation cycle

100. The neuromuscular junction

101. Structural and functional differences between skeletal and smooth muscles. Mechanism of smooth muscle contraction

102. Membrane potential and action potential: explain their ionic mechanisms. Membrane properties of CNS neurons

103. The compound action potential. Conductive properties of various nerve fibres

104. Neurochemistry of synapses, neurotransmitters, postsynaptic receptors and neuromodulators. EPSP, IPSP

105. The myotatic (stretch) reflex. Gamma motoneurons

106. The motor units. Central control of muscle contractions

107. Types of mechanoreceptors and their role in motor control

108. How do cutaneous mechanoreceptors help to explore, learn and know our environment?

109. Somatosensory mechanisms of spinal cord and brain stem

110. Pain mechanisms, central and peripheral components

111. Descendent control (gating) of nociception and of pain reactions

112. Organisation of primary somatosensory cortex, thalamocortical projection and somatotopy

113. The human electroencephalogram (EEG). Evoked potential (EP) technique

114. Neural mechanisms of sleep and correlated somatic, autonomic and bioelectrical phenomena. The role of reticular formation in the sleep-wakefulness cycle

115. The diencephalon (hypothalamus), its motor, autonomic and hormonal regulatory function

116. Hunger and thirst. Central regulatory processes of food and water intake

117. Central mechanisms of locomotion

118. Decerebration rigidity and spinal shock (symptoms and mechanisms)

119. Postural and righting reflexes, their central mechanisms and localisation within the spinal cord, brain stem and neocortex

120. Structure and function of the extrapyramidal system

121. Symptoms after damages of different extrapyramidal structures. Role of neurotransmitters in the extrapyramidal functions

122. Importance of the cerebellum in co-ordination of movements

123. Cerebellar cortical mechanisms


37

124. Structure and function of the vestibular system

125. Functions of the autonomic nervous system. Autonomic reflexes

126. Humoral mediators in the autonomic nervous system. Adrenergic, cholinergic and opioid receptors

127. Structures, connections and functions of the limbic system

128. Functions of the motor cortex. Symptoms following its damage

129. Corticospinal (pyramidal) system. Consequences of lesions of the pyramidal pathways and the peripheral motoneuron

130. The concept of drive and motivation. Their integrated neural mechanisms. Reticular activating system

131. Emotions and their central nervous mechanisms

132. The phenomena of operant (instrumental) and classical (Pavlovian) conditioning. Mechanism of reinforcement

133. Electrical and chemical self-stimulation. Rewarding (positive) and punishing (negative) reinforcement. Simple learning processes. Exceptional forms of conditioning

134. Types and disorders of memory functions

135. Cerebral dominance. Lateralisation of functions in the hemispheres. Split-brain examinations

136. Functions of the parietal and temporal association (intrinsic) areas of the neocortex. Symptoms after damages (apraxia, agnosia)

137. Neurophysiological mechanisms of speech. Speech disorders

138. Functions of the frontal lobe (prefrontal intrinsic area)

139. Functions of the temporal lobe (Kluver-Bucy syndrome)

140. Central monoaminergic systems and their functional significance

141. Peripheral auditory mechanisms (conductive apparatus and cochlea)

142. Central auditory pathways, acoustic cortex and related mechanisms

143. Physiological optics

144. The retina. Photoreceptors and neuronal functions in the retina

145. Central visual pathways, the visual cortex and their functions

146. Colour vision. Stereoscopic vision

147. Peripheral and central mechanisms of olfaction

148. Peripheral and central mechanisms of sensation of taste

149. Plasticity in the nervous system. Consequences of sensory deprivation in the visual cortex. Ageing. Transplantation

Questions for the student lab report:

1. Examination of oestrus cycle in rat

2. Different tests of pregnancy

3. Determination of human blood glucose level

4. Direct and indirect stimulation of nerve-muscle preparation;

5. Recording of a twitch contraction; Effects of repetitive stimulation muscles (complete and incomplete tetanus)

6. Effect of load on muscular contraction

7. Examination of fatigue in nerve-muscle preparation and on humans

8. Electromyographic registration methods (EMG)

9. Measurement of conduction velocity

10. Recording of a compound action potential of peripheral nerve trunks

11. The law of polar excitation

12. Demonstration of the Pflüger’s law

13. Measurement of rheobase and chronaxy

14. Effect of narcosis on peripheral nerves

15. Examination of reflexes in a frog (intact and spinal animal)

16. Examination of reflexes in the human

17. Stereotaxic technique

18. Reflex time, reaction time and action time

19. Electroencephalogram (EEG)

20. Measurement of visual acuity

21. Refractive errors and their corrections

22. Measurement of astigmia

23. Examination of pupil reactions

24. Perimetry

25. Examination of colour weakness and colour blindness

26. Audiometry

Participants

Kovács Anita (KOAMAET.PTE)


38

OPO-FA2 PHARMACOBOTANY 2

Course director: DR. ÁGNES FARKAS, associate professor

Department of Pharmacognosy

3 credit ▪ semester exam ▪ Pharmaceutical biology and medical theoretical knowledge module ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 3 – 80 Prerequisites: OPO-GN1 completed

Topic

Pharmacobotany covers all pharmaceutical aspects of botany, including cytology, histology, morphology and taxonomy of plants. Plant

systematics discusses the geographical origin of plant species, the possibilities of cultivation and nature conservation. A special emphasis

is laid on chemotaxonomic aspects, since the medicinal effect of a plant is often related to its taxonomic classification and chemical

characteristics. Practical instruction focuses on the knowledge of medicinal plants, including the confident usage of plant identification

keys. Based on their knowledge of histology students are required to apply proper anatomical terms, and finally identify plant species

(taxa). The thorough knowledge of both general and specific pharmacobotany is a prerequisite of studying pharmacognosy.



Mid-term exams

Students have to pass (min. 60%) two written exams based on lecture materials. If necessary, students will be provided maximum two

extra chances (B and C chance) besides the original exam date (A chance).

From the 2nd week onwards, students have to write a short test each week (recognising and characterising 5-5 medicinal plants).


Participation is compulsory in lab practicals; up to 2 absences are allowed. Missed practicals can be made up either by joining the other

groups or taking extra time at the following lab practical. In all cases, students must make arrangements with their lab instructors in

advance.

Reading material


Á. Farkas: Pharmacobotany 2. University of Pécs, Institute of Pharmacognosy, Pécs, 2016

N. Papp: Pharmacobotany Practices. University of Pécs, Institute of Pharmacognosy, Pécs, 2011


Farkas Á., Papp N., Bencsik T., Horváth Gy.: Digital Herbarium and Drug Atlas, electronic learning material, 2014 TÁMOP-

4.1.2.A/1-11/1-2011-0016

- Notes


Z. Yaniv, U. Bachrach (eds.): Handbook of Medicinal Plants, Haworth Press Inc., 2005

WHO Monographs on Selected Medicinal Plants, Vol. 1. (1999), Vol. 2. (2002)

Lectures

1 Algae (Phaeophyceae, Rhodophyceae), Fungi, Lichenes

Dr. Farkas Ágnes

2 Pteridophyta, Coniferophytina, Cycadophytina. Magnoliidae.

Dr. Farkas Ágnes

3 Caryophyllidae

Dr. Farkas Ágnes

4 Hamamelididae

Dr. Farkas Ágnes

5 Rosidae I.

Dr. Farkas Ágnes

6 Rosidae II.

Dr. Farkas Ágnes

7 Dilleniidae

Dr. Farkas Ágnes

8 Cornidae

Dr. Farkas Ágnes


39

9 Lamiidae I.

Dr. Farkas Ágnes

10 Lamiidae II.

Dr. Farkas Ágnes

11 Asteridae

Dr. Farkas Ágnes

12 Alismatidae. Liliidae.

Dr. Farkas Ágnes

13 Zingiberidae

Dr. Farkas Ágnes

14 Commelinidae, Arecidae

Dr. Farkas Ágnes

Practices

1 Fungi: Morphology of Ganoderma lucidum, Fomes fomentarius and Lentinus edodes. Lichenes: Morphological comparison of

Cladonia pyxidata and Cetraria islandica.

2 Pteridophyta: Spores and sporangia of Lycopodium clavatum and Equisetum arvense; rhizome of Dryopteris filix-mas.

3 Spermatophyta: Coniferophytina: Inflorescences, needles and wood of Pinus nigra.

4 Angiospermatophytina: Dicotyledonopsida: Magnoliidae: Aristolochiaceae, Ranunculaceae, Helleboraceae. Aristolochia shoot,

Ficaria root and leaf, Helleborus leaf.

5 Berberidaceae, Papaveraceae, Fumariaceae, Papaver sp. pistil and fruit.

6 Caryophyllidae: Phytolaccaceae, Polygonaceae, Caryophyllaceae. Saponaria officinalis root.

7 Hamamelididae: Fagaceae, Betulaceae, Juglandaceae. Leaf morphology and fruit types of Fagus and Quercus species. Juglans

regia fruit.

8 Plant identification practice with identification key.

9 Rosidae I.: Grossulariaceae, Crassulaceae, Rosaceae. Sedum sp. shoot, Rosa canina pseudofruit, Malus domestica nectary,

Rosaceae fruit types.

10 Rosidae I.: Fabaceae. Starch grains of Phaseolus vulgaris and Pisum sativum.

11 Rosidae II.: Araliaceae: Morphological features of Hedera helix and Panax ginseng. Apiaceae. Fruit of Carum carvi and

Foeniculum vulgare.

12 Rosidae II.: Punicaceae, Lythraceae, Onagraceae, Rutaceae. Hesperidium and shoot of Citrus limon.

13 Rosidae III.: Anacardiaceae, Hippocastanaceae, Geraniaceae, Celastraceae, Rhamnaceae. Pelargonium zonale non-glandular and glandular trichomes.

14 Rosidae III.: Vitaceae, Araliaceae, Violaceae, Cistaceae, Cucurbitaceae. Shoot of Bryonia alba or Cucumis sativus with bicollateral vascular bundles.

15 Dilleniidae: Brassicaceae, Salicaceae, Tiliaceae, Cannabaceae. Bifid hairs and glandular scales of Humulus lupulus. Malvaceae, Moraceae, Urticaceae, Buxaceae. Urtica dioica stinging hairs.

16 Dilleniidae: Euphorbiaceae, Elaeagnaceae, Hypericaecae. Laticifers and starch grains of Euphorbia sp., stellate hairs of Elaeagnus angustifolia. Primulaceae.

17 Cornidae: Caprifoliaceae, Valerianaceae, Rubiaceae. Sambucus nigra shoot.

18 Cornidae: Apocynaceae. Asclepiadaceae. Nerium oleander leaf. Plant identification practice.

19 Lamiidae I.: Solanaceae: Solanum tuberosum starch grains. Convolvulaceae.

20 Lamiidae I.: Boraginaceae, Plantaginaceae. Boraginaceae non-glandular trichomes. Scrophulariaceae, Verbenaceae. Verbascum phlomoides hairs.

21 Lamiidae II.: Lamiaceae.

22 Lamiidae II.: Lamiaceae-type glandular hairs on the leaf of Lavandula sp.. Salvia officinalis shoot.

23 Asteridae: Asteraceae

24 Asteridae: Secondary thickening in the stem of Helianthus annuus. Taraxacum officinale rhizome.

25 Monocotyledonopsida: Dioscoreaceae, Convallariaceae, Asparagaceae, Ruscaceae. Convallaria majalis rhizome.

26 Monocotyledonopsida: Alliaceae, Orchidaceae, Poaceae. Root tip and leaf of Allium sp., scale leaves of Allium cepa.

27 Visit to the botanical garden.

28 Visit to the medicinal plant garden.

Seminars


40


Final exam:

Entrance exam:

Preceding the oral exam, 5 medicinal plants should be identified and their brief morphological characterization should be given.

Oral exam:

Following the successful entrance exam, students are required to present their knowledge on 2 topics from the list below. The

general characterization of plant families should be followed by the morphological and chemotaxonomic description of the species belonging to the given families.

Exam questions:

1. Algae, Fungi, Lichenes

2. Lycopodiaceae, Equisetaceae, Aspidiaceae, Polypodiaceae

3. Ginkgoaceae, Abietaceae, Cupressaceae, Taxaceae, Ephedraceae

4. Myristicaceae, Illiciaceae, Lauraceae, Piperaceae, Aristolochiaceae

5. Berberidaceae, Ranunculaceae (Helleboraceae)

6. Papaveraceae, Fumariaceae

7. Chenopodiaceae, Caryophyllaceae, Polygonaceae

8. Hamamelidaceae, Fagaceae, Betulaceae (Corylaceae), Juglandaceae

9. Droseraceae, Rosaceae

10. Mimosaceae, Caesalpiniaceae, Fabaceae

11. Myrtaceae, Punicaceae, Lythraceae, Onagraceae

12. Rutaceae, Anacardiaceae

13. Hippocastanaceae, Geraniaceae, Linaceae, Erythroxylaceae

14. Polygalaceae, Krameriaceae, Rhamnaceae, Vitaceae, Loranthaceae

15. Araliaceae, Apiaceae

16. Violaceae, Passifloraceae, Caricaceae, Cucurbitaceae

17. Brassicaceae, Salicaceae

18. Tiliaceae, Sterculiaceae, Malvaceae

19. Moraceae, Cannabaceae

20. Urticaceae, Euphorbiaceae

21. Elaeagnaceae, Theaceae, Hypericaceae, Primulaceae

22. Aquifoliaceae, Caprifoliaceae (Sambucaceae), Valerianaceae, Ericaceae

23. Loganiaceae, Rubiaceae

24. Apocynaceae, Gentianaceae, Menyanthaceae, Oleaceae

25. Solanaceae, Convolvulaceae

26. Boraginaceae, Scrophulariaceae

27. Plantaginaceae, Pedaliaceae, Verbenaceae

28. Lamiaceae

29. Lobeliaceae, Asteraceae (Cichoriaceae)

30. Dioscoreaceae, Convallariaceae, Asparagaceae, Ruscaceae, Agavaceae

31. Asphodelaceae, Hyacinthaceae, Alliaceae

32. Amaryllidaceae, Melanthiaceae, Colchicaceae, Iridaceae, Orchidaceae

33. Zingiberaceae, Bromeliaceae, Poaceae, Arecaceae

Participants

Dr. Papp Nóra (PANAAA.T.JPTE)


41

OPR-SG1 PROFESSIONAL PRACTICE 1

Course director: DR. KLÁRA MAYER, assistant professor

Department of Pharmacotechnology

0 credit ▪ signature ▪ Criterion requirement module ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 1 – 70 Prerequisites: OPG-GI1 parallel

Topic

Aim of summer pharmacy practice after the 4th semester is to expose the pharmacy as a healthcare institution.

Student is allowed to execute the practice in a pharmacy or in a clinical/hospital pharmacy or in pharmaceutical industry/factory. It is also allowed to split the four week practice into 2-2 weeks in order to spend the practice at both places.

Proposal in the Hungarian pharmacy practice with Hungarian Student together.


Student can only work under the supervision of the tutor pharmacist or other assigned person.

Brief daily report must be done during the practice which has to be presented on course of Pharmaceutical Technology 1.

Mid-term exams


4 weeks of practice can be split into two parts due to illness.

Reading material



- Notes

Pharmaceutical Propedeutic, Basic Principles of Pharmacy,


European Pharmacopoeia

Pharmacopoeia Hungarica

Hungarian National Formulary: Formulae Normales VII (FoNo VII)

Compendium

Lectures

Practices

1-160 Knowing duties of pharmacists and the pharmacy

Knowing places in pharmacy

Storage of medicines, assuring storing conditions in pharmacy

Pharmaceutical appliances, instrumentation, knowing scales

Studying pharmaceutical ingredients, excipients

Packaging and labeling magistral preparations

Practicing basic technological procedures

Knowing rules and regulations of work in pharmacy

..

Pharmaceutical factory

Pharmaceutical industry works

Good Manufactory Practice (GMP)

The key persons in the factory

Quality Assurance, Qualify Person, responsibility

Production area, production process

Microbiology in the pharmaceutical industry

..

Seminars


Knowledge acquired is evaluated based on reports made during pharmacy practice.


42

Participants

Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Rezesné dr. Börzsei Rita Judit (BORPAAO.PTE)


43

OPR-HUF-O FINAL EXAMINATION IN HUNGARIAN PHARMACEUTICAL TERMINOLOGY - ORAL

Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor

Department of Languages for Specific Purposes

0 credit ▪ signature ▪ Criterion requirement module ▪ both semesters semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 1 – 400 Prerequisites:

Topic

Exam of Pharmaceutical Hungarian language skills required for the pharmaceutical practice.


Mid-term exams


Reading material



- Notes


Lectures

Practices

Seminars


Participants

UP MS Dentistry major – subjects of the Basic module - Course descriptions – academic year of 2016/2017

1

OPR-HUF-W FINAL EXAMINATION IN HUNGARIAN PHARMACEUTICAL TERMINOLOGY - WRITTEN

Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor

Department of Languages for Specific Purposes

0 credit ▪ signature ▪ Criterion requirement module ▪ both semesters semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 1 – 400 Prerequisites:

Topic

Exam of Pharmaceutical Hungarian language skills required for the pharmaceutical practice.


Mid-term exams


Reading material



- Notes


Lectures

Practices

Seminars


Participants

UP FP Pharamceutist major – obligatory subjects of the 3-4. semester - Course descriptions – academic year of 2016/2017

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ATT1-2-3-4 PHYSICAL EDUCATION 1-2-3-4

Course director: TAMÁS TÉCZELY, physical education teacher

Physical Education and Sports Center

0 credit ▪ signature ▪ Criterion requirement module ▪ both semesters semester ▪ recommended semester: 1 -2-3-4


Course headcount limitations (min.-max.): 2 – 50 Prerequisites: none / ATT1 / ATT2 / ATT3

Topics

The main goal of the university’s physical education is the development of our students' health. To prevent injuries, in the introductory

part of the sessions warming up of different muscle groups. We are improving the fitness stamina and strength of our students through

the sport movements and by using modern training methods. The practice of sport by becoming familiar with the rules of the game. Our task is to incorporate regular physical activity into the lifestyle of the students.

Course type:

Criteria requirement

During the general medical education until the end of the 10th semester, for dentists and pharmacists until the end of the 8 semester the

implementation of four semester regular physical activity is obligatory. They have to participate in 28 lessons of physical education on

weekly basis. (Two lessons weekly.) Due to fulfilling the requirements they can not enrol for the next semester. The organization, the

direction and the control are done by the teachers in charge of the workshops or by persons delegated by the dean of the Medical School We record the presence of the students. We verify the completion of the semester by confirmation of the registration plate in ETR system.

Conditions for acceptance of the semester:

The minimum requirement for acceptance of the semester is to attend on a ten week session training. During semester 4x45 minutes

absence is allowed. Accepting additional 4x45 minutes absence is the competence of the supervisor.

Possible absence:

We provide 6x45 minutes as a catching up time, which should be approved by the teacher. The catch up sessions have to be fulfilled during the last three weeks of semester.

Practices

The selection of the sport movements depends on the chosen game.

Exam questions

The acceptance of the semester is not connected to exam.

PE teachers

Farkas György (FAGMAAO.PTE), Finak Gáborné Gombosi Eszter (FIGMAAT.PTE) Lipcsik Zoltán (LIZIAAT.PTE), Németh Attila

(NEAGAET.PTE), Dr. Rugási Endre (RUEMAAP.PTE), Téczely Tamás (PETLAAT.PTE)


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Sport Day From To Place Min. Max. Teacher Supervisor

Aerobics Monday 18:00 19:00 SPO-SOR Sörház (Xavér str 19)

2 8 Dr. Szilárdné Kordély Erika

Aerobics Tuesday 19:00 20:00 SZEA-EDZ Main Building training room

2 8 Kerekes Kamilla

Aerobics Wednesday 18:00 19:00 SPO-SOR Sörház (Xavér str 19)


Aerobics Wednesday 19:00 20:00 SPO-SOR Sörház (Xavér str 19)

2 8 Kerekes kamilla

Aerobics Thursday 18:00 19:00 SPO-GYM Professor Gym (Megyeri str. 4)


Aerobics (pompom) Tuesday 19:00 20:30 SPO-SZT Gymnastics hall (Ifjúság út 6.)

2 6 Rill Leila

Athletics Monday 17.00 18.30 SPO-ATP PTE Athletics field (Ifjúság rd. 6.)

1 8 Hajduné Dr. László Zita

Athletics Friday 16.00 17.30 SPO-ATP PTE Athletics field (Ifjúság rd. 6.)


Badminton (Student Sports Club)

Thursday 16:30 17:45 SPO-TCS Sportshall - Jakabhegyi út 6.

2 7 Lipcsik Zoltán Farkas György

Basketball (men) Thursday 22:00 23:30 SPO-TCS Sportshall - Jakabhegyi út 6.

4 20 Németh Attila Miklós

Basketball (women) (Student Sports Club)

Wednesday 18:00 19:30 SPO-TCS Sportshall - Jakabhegyi út 6.


Farkas György

Box Thursday 18:00 19:00 SPO-SRC Slyven Ring and Caffe (Mezőszél u. 1.)

1 3 Alvics Gyula

Cardio Yoga Friday 15:00 16:30 SZEA-EDZ Main Building training room

2 10 Ragács Renáta

Climbing Thursday 17:30 19:00 SPO-PSM "Pécsi Sasok" Sportscenter (Búza tér 6/b.)

2 6 Téczely Tamás

Cross training Tuesday 21.00 22.30 SPO-CRF Cross Factory, Professor Gym court Megyeri út 4.)

1 6 Téczely Tamás

Dancing University Project - Ballroom Dancing

Thursday 20:30 22:00 SPO-I6T Dance Room (Ifjúság Street 6.)

1 4 Dr. Papp Judit Bánkyné Perjés Beatrix

Dancing University Project - Ballroom Latin Dances

Tuesday 20:30 22:00 SPO-I6T Dance Room (Ifjúság Street 6.)

1 4 Józsa János Bánkyné Perjés Beatrix

Dancing University Project - Belly Dance


1 4 Indzsi Deniz Bánkyné Perjés Beatrix

Dancing University Project - Body Shaping Dance Aerobics


1 4 Szuhán-Glass Beáta

Bánkyné Perjés Beatrix

Dancing University Project - Boogie-Woogie, Rock 'n' Roll, Swing

Monday 15:30 17:00 SPO-I6T Dance Room (Ifjúság Street 6.)

1 4 Szauer Zoltán Bánkyné Perjés Beatrix

Dancing University Project - Croatian, Serbian and Macedonian Dances


1 4 Vélin Veszna Bánkyné Perjés Beatrix

Dancing University Project - Cuban Salsa

Wednesday 17:30 19:00 SPO-I6T Dance Room (Ifjúság Street 6.)

1 4 Vágási Barbara, Kutni Balázs



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Dancing University Project - Hip-hop


1 4 Horváth Tamás Bánkyné Perjés Beatrix

Dancing University Project - Hungarian Folk Dance beginner


1 4 Tandiné Mosgai Andrea, Tandi Tibor


Dancing University Project - Latin Freestyle Aerobics


1 4 Szabó Adrienn Bánkyné Perjés Beatrix

Dancing University Project - Show/Musical Dance


1 4 Dr. Papp Judit Bánkyné Perjés Beatrix

Dancing University Project - Yoga

Wednesday 15:00 16:30 SPO-I6T Dance Room (Ifjúság Street 6.)

1 4 Gyenis Boglárka Bánkyné Perjés Beatrix

Football Friday 13:30 15:00 SPO-TCS Sportshall - Jakabhegyi út 6.

6 15 Téczely Tamás

Football Friday 15:00 16:30 SPO-TCS Sportshall - Jakabhegyi út 6.


Handball (men) (Student Sports Club)



Handball (women) (Student Sports Club)

Monday 17:30 19:00 SPO-TCS Sportshall - Jakabhegyi út 6.


Hiking (weekends, Mecsek)

hétvégente Mecsek 2 10 Farkas György

Horse Riding Thursday 17:00 18:30 SPO-PEA former PEAC Sportshall and sports field - Sport u. 1.

1 2 Bohár Áron Téczely Tamás

Jalagati + Wednesday 19:00 20:30 SPO-RSG RG Terem Ifjúság út 6.

1 2 Dr. Dudás Anna

Karate advanced (Student Sports Club)

Thursday 20:00 21:30 SZEA-EDZ Main Building training room

2 7 József Kristóf Farkas György

Karate beginner (Student Sports Club)

Tuesday 20:00 21:30 SZEA-EDZ Main Building training room

2 7 József Kristóf Farkas György

Kick-box Friday 19:00 20:30 SZEA-EDZ Main Building training room

2 12 Horváth László

Lacross Friday 19:00 20:30 SPO-V13 PTE Sports sites (Verseny u. 13.)

2 10 Dr. Rugási Endre

Nordic Walking Friday 16.00 17.30 SPO-ATP PTE Athletics field (Ifjúság út 6.)


Operational Medicine Training Program

Tuesday 16.15 17.30 SZEA-EDZ Main Building training room

1 6 Lipcsik Zoltán

Operational Medicine Training Program

Thursday 19.00 17.30 SZEA-EDZ Main Building training room

1 6 Dr. Karsai István

Other sportclubs from Pécs (with permission)


PTE- PEAC (Sport Club) (with permission)


Shaolin Kung Fu Monday 19:00 20:30 SPO-EP8 Elementary School in 8 Építők Str.

1 4 Bornemissza Gergely

Squash Friday 16:30 18:00 SPO-SOR Sörház (Xavér str 19)

2 4 Téczely Tamás


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Swimming Tuesday 12:00 13:30 SZEA-USZ Main Building swimming pool


Swimming Friday 13:30 15:00 SZEA-USZ Main Building swimming pool

3 15 Farkas György

Swimming Friday 15:00 16:00 SZEA-USZ Main Building swimming pool

3 15 Finak Gáborné Gombosi Eszter Gyöngyi

Table Tennis Thursday 13:30 15:00 SZEA-EDZ Main Building training room


Table Tennis Thursday 15:00 16:15 SZEA-EDZ Main Building training room

4 16 Farkas György

Table Tennis Friday 13:30 15:00 SZEA-EDZ Main Building training room


Tennis Thursday 18:00 19:00 SPO-MAT Makár Tanya Sports Center (Középmakár dűlő 4.)

2 6 Daróczi Balázs

Track and Field training

Tuesday 17:00 18:30 SPO-JSK Jakabhegy street outdoor handball field


Track and Field training

Friday 17:00 18:30 SPO-JSK Jakabhegy street outdoor handball field


Training in the Gym Wednesday 12:00 13:30 SPO-GYM Professor Gym (Megyeri str. 4)

2 10 Lipcsik Zoltán

Training in the Gym Friday 12:00 13:30 SPO-GYM Professor Gym (Megyeri str. 4)

4 20 Lipcsik Zoltán

Training in the Gym Friday 13:30 15:00 SPO-GYM Professor Gym (Megyeri str. 4)


Volleyball (men) (Student Sports Club)


2 7 Storcz Tamás Farkas György

Volleyball (women) (Student Sports Club)

Tuesday 16:30 18:00 SPO-TCS Sportshall - Jakabhegyi út 6.

2 7 Demeter András Farkas György

XCO Training Monday 19:00 20:00 SPO-MFK Mecsek Fitness Center (Ybl Miklós str. 10.)

2 7 Szőke Zita

Yoga Sunday 18:00 20:00 SPO-SOR Sörház (Xavér str 19)

2 10 Briest Charlotte

Zumba (fee payment necessary)

Wednesday 18:00 19:00 SPO-FOR Fordan Dance Center - Batthyány u. 9/a.

2 10 Varga Zsuzsanna

study program 2016/2017 subjects of the 3-4. … · 6 2 investigation of the behavior of terner...

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