study demonstrates effectiveness of combination therapy for breast cancer cells in vitro
DESCRIPTION
Study Demonstrates Effectiveness of combination therapy for breast cancer cells in vitroTRANSCRIPT
EMMANUEL ALVAREZ
LONDOÑO
MEDICINE STUDENT
III SEMESTER
UNIVERSIDAD PONTIFICIA
BOLIVARIANA
MOLECULAR BIOLOGY
“STUDY DEMONSTRATES EFFECTIVENESS OF
COMBINATION THERAPY FOR BREAST CANCER
CELLS IN VITRO” AND “SAFER
ALTERNATIVE TO EXPERIMENTAL GENE
THERAPY AGAINST HIV INFECTION”
Consists of a combination therapy focused on breast cancer cells, including those resistant to chemotherapy, which was used in a HDACi and a calpain inhibitor.
This method of scientists is more secure than normal and gene therapy is both a protein with zinc finger nuclease (ZFN) and a nuclease, these work together one selects the exact gene and over the short chain DNA.
INTRODUCTION
“STUDY DEMONSTRATES EFFECTIVENESS OF COMBINATION THERAPY FOR BREAST CANCER CELLS IN VITRO”
NEWS-MEDICALS(JULY. 3, 2012)
• The anti-cancer treatment by Boston University, not only serves the triple negative breast cancer, also for other cancers resistant to chemotherapy and other treatments.
• This combination therapy seeks genes that are silenced are expressed to produce the inhibitor of cell growth, and thus control the triple negative breast cancer.
“STUDY DEMONSTRATES EFFECTIVENESS OF COMBINATION THERAPY FOR BREAST CANCER CELLS IN VITRO”
NEWS-MEDICALS(JULY. 3, 2012)
HER2 is an oncogene, there are drugs such as Herceptin to help combat the problem in triple negative breast cancer is HER2 or not is another type of marker, so this is so deadly cancer and its treatment is so complex.
The triple negative breast cancer is very aggressive and metastatic, resistant to treatment with Herceptin, in charge of uniting with HER2 signal and stimulate growth arrest and cell spreading.
The therapy used in this research is to inhibitors of histone deacetylases of (HDACi) and calpeptin, calpain calpeptin inhibits a protein responsible for signaling and promote cell cycle.
“STUDY DEMONSTRATES EFFECTIVENESS OF COMBINATION THERAPY FOR BREAST CANCER CELLS IN VITRO”
NEWS-MEDICALS(JULY. 3, 2012)
The study yielded very positive results, the cells increased cell death, inhibitors were expressed and decreased the spread and growth of cancer cells.
The study should be further investigated, as was conducting in vitro, but so far gives results very positive and encouraging for modern medicine.
“STUDY DEMONSTRATES EFFECTIVENESS OF COMBINATION THERAPY FOR BREAST CANCER CELLS IN VITRO”
NEWS-MEDICALS(JULY. 3, 2012)
OBSERVATION
I think a study that has very good looking, has a clear goal and so far the results have been very encouraging. From what I could investigate the news I think the drugs used in this combination therapy will be effective in vivo study, are focused on key cell cycle inhibitors and propagation and cell growth.
Scientists have designed a method to eliminate the CCR5 receptor, which becomes resistant to T cells against HIV.
the ZFN is responsible for marking a specific gene and nuclease cuts it, these two proteins are highly accurate.
“SAFER ALTERNATIVE TO EXPERIMENTAL GENE THERAPY AGAINST HIV INFECTION”
NEWS-MEDICALS(JULY. 2, 2012)
ZFN proteins were added to T cells and was diminished in these CCR5 means that if the gene inactive.
In this therapy is also working on trying to reprogram fibroblasts lot of his to become stem cells.
“SAFER ALTERNATIVE TO EXPERIMENTAL GENE THERAPY AGAINST HIV INFECTION”
NEWS-MEDICALS(JULY. 2, 2012)
Retroviruses as vectors in gene therapy have a significant drawback, namely that the integrase enzyme can insert the genetic material in any area of the host genome.
“SAFER ALTERNATIVE TO EXPERIMENTAL GENE THERAPY AGAINST HIV INFECTION”
NEWS-MEDICALS(JULY. 2, 2012)
If the result in the transformation of fibroblasts into stem cells, would be an effective therapy for patients with HIV, as it would replace its new T cells infected lymphocytes and also resistant to the virus, this is the goal they want to meet the scientists who made this study suggest that "Even a small number of stem cells that lead to this characteristic of HIV resistance could reach a patient completely replace the original T cell population and vulnerable"
“SAFER ALTERNATIVE TO EXPERIMENTAL GENE THERAPY AGAINST HIV INFECTION”
NEWS-MEDICALS(JULY. 2, 2012)
OBSERVATION
I think a study that may come to accomplish great results, but I think it is a big barrier and that is like discovering an effective and safe to enter the cell ZFN, a vector that is not a virus, could be a lipid molecule, as a kind of micelle, capable of traversing the membrane and into
the cytosol is capable of releasing its contents.
MEDICAL UTILITY“STUDY DEMONSTRATES EFFECTIVENESS OF COMBINATION
THERAPY FOR BREAST CANCER CELLS IN VITRO”
For treatment of breast cancer have several treatments, including the Herceptin,
tamoxifen, aromatase inhibitor and other more, but for triple negative breast cancer
there are very few treatments and there are not very effective, this New therapy proposed by the University of Boston, is useful for the large percentage of people suffering from
this aggressive disease.
MEDICAL UTILITY“STUDY DEMONSTRATES EFFECTIVENESS OF COMBINATION
THERAPY FOR BREAST CANCER CELLS IN VITRO”
This combination therapy seeks genes that are silenced are expressed to produce the inhibitor of cell growth, and thus control the triple negative
breast cancer, but not only this type of cancer also for certain cancers that are resistant to
chemotherapy and other antineoplastic drugs, which would contribute to the preservation of human life
and the improvement of the quality of this.
The medical utility of this method is basically very large AIDS treatment and prevention of this disease every day is
expanding worldwide, it is possible that in the future from this method is invented a type of vaccine to prevent AIDS,
becoming resistant to all of our T cell Also in AIDS, can be very useful method of cutting this gene, when hematopoietic stem cells reprogrammed to assist the production of new healthy T
lymphocytes.
MEDICAL UTILITY“SAFER ALTERNATIVE TO EXPERIMENTAL GENE THERAPY
AGAINST HIV INFECTION”
AIDS not only in this study may be necessary, also in other disease associated with genetic alterations, such as enzyme deficiencies or structural alterations, would be replaced by
another gene expression and would give the necessary reconfiguration also in hematopoietic stem cell would be
effective in the treatment of leukemias and anemias the large amount of the world.
AIDS not only in this study may be necessary, also in other disease associated with genetic alterations,
such as enzyme deficiencies or structural alterations, would be replaced by another gene
expression and would give the necessary reconfiguration also in hematopoietic stem cell
would be effective in the treatment of leukemias and anemias the large amount of the world.
MEDICAL UTILITY“SAFER ALTERNATIVE TO EXPERIMENTAL GENE THERAPY
AGAINST HIV INFECTION”
Martinez S, Lina Maria. Biología Molecular. 5 ed Medellín: UPB. Fac Medicina
Study Demonstrates Effectiveness of combination therapy for breast cancer cells in vitro. News-Medicals. July 3, 2012.
Safer alternative to experimental gene therapy against HIV infection .News-Medicals. July 2, 2012.
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