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Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies Aleksandr E. Miklos, Christien Kluwe, Bryan S. Der, Supriya Pai, Aroop Sircar, Randall A. Hughes, Monica Berrondo, Jianqing Xu, Vlad Codrea, Patricia E. Buckley, Alena M. Calm, Heather S. Welsh, Candice R. Warner, Melody A. Zacharko, James P. Carney, Jeffrey J. Gray, George Georgiou, Brian Kuhlman, Andrew D. Ellington Chemistry & Biology Volume 19, Issue 4, Pages 449-455 (April 2012) DOI: 10.1016/j.chembiol.2012.01.018 Copyright © 2012 Elsevier Ltd Terms and Conditions

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Page 1: Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies Aleksandr E. Miklos, Christien Kluwe, Bryan S. Der, Supriya Pai, Aroop Sircar,

Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies 

Aleksandr E. Miklos, Christien Kluwe, Bryan S. Der, Supriya Pai, Aroop Sircar, Randall A. Hughes, Monica Berrondo, Jianqing Xu, Vlad Codrea, Patricia E. Buckley, Alena M. Calm, Heather S. Welsh, Candice R. Warner, Melody A. Zacharko, James P. Carney, Jeffrey J.

Gray, George Georgiou, Brian Kuhlman, Andrew D. Ellington 

Chemistry & Biology Volume 19, Issue 4, Pages 449-455 (April 2012)

DOI: 10.1016/j.chembiol.2012.01.018

Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies Aleksandr E. Miklos, Christien Kluwe, Bryan S. Der, Supriya Pai, Aroop Sircar,

Figure 1

Chemistry & Biology 2012 19, 449-455DOI: (10.1016/j.chembiol.2012.01.018) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies Aleksandr E. Miklos, Christien Kluwe, Bryan S. Der, Supriya Pai, Aroop Sircar,

Figure 2

Chemistry & Biology 2012 19, 449-455DOI: (10.1016/j.chembiol.2012.01.018) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies Aleksandr E. Miklos, Christien Kluwe, Bryan S. Der, Supriya Pai, Aroop Sircar,

Figure 3

Chemistry & Biology 2012 19, 449-455DOI: (10.1016/j.chembiol.2012.01.018) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

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