strategic support for advanced therapiesinnovate uk – advanced therapies building our in addition...

UK Research and Innovation

UK Research and Innovation #IndustrialStrategy

Building our

Strategic support for advanced therapies

AMC Meeting Oxford 14 March 2019

Ian McKay – Innovation Lead – Advanced Therapies

[email protected]



Building our

•  we sit at the heart of delivering government’s Industrial Strategy and target of UK R&D expenditure reaching 2.4% of GDP

•  we act as a transformative agent for change in the UK economy by accelerating productivity and driving disruptive innovation

•  we support innovation, from spin-outs and start-ups to companies with the ambition to scale and grow in the UK and through global markets

•  we help companies of all sizes in all sectors access the research, partners, investors and markets they need to innovate and grow

The UK’s innovation agency



Building our

8,000 Unique organisations involved

Up to

£7.30 For every £1 we’ve invested

£2.2bn Since 2007

We’ve funded around

11,000 projects

Up to

£16bn in added value to the economy

Investment of Industry match funding taking the total value of projects above

£3.75bn

70,000 Jobs created in total

8 jobs For each organisation involved

3



Building ourInnovate UK – Advanced Therapies

In addition to our Regenerative Medicine & Cell Therapy themed CR&D competitions companies have been successful in securing grants through

•  Biomedical Catalyst •  Smart •  KTP •  Materials & Manufacturing and other themed

competitions

+£32m Additional

funding from industry

£67m CR&D grants

awarded

>140 Advanced therapies

projects funded



Building our


Jan-Mar 2017

Apr-Jun 2017

Jul-Sep 2017

Oct-Dec 2017

Jan-Mar 2018

Apr-Jun 2018

Jul-Sep 2018

Wave 1 ISCF announced

Wave 2 ISCF announced

IndustrialStrategyandLifeSciencesSectorDeal

Oct-Dec 2018



Building ourIndustrial Strategy Challenge Fund

•  Delivers the science that business needs to transform existing industries and create new ones

•  Accelerates commercial exploitation of the most exciting technologies the UK has to offer the world

•  Ensures that scientific investment truly delivers economic impact, jobs and growth right across the country

•  Industry-led and powered by multi-disciplinary research and business-academic collaboration



Building our

Ageing Society Future of mobility

Industrial Strategy Challenge Fund


AI and Data Economy

National Satellite Test Facility

Audience of the future

Quantum technologies

Next generation services

Made smarter

Leading-edge healthcare (inc. medicines manufacturing)

Data to early diagnosis and precision medicine

Healthy ageing

Accelerating detection of disease

Self-driving vehicles

Manufacturing and materials of the future

Faraday battery challenge

Robots for a safer world

Driving the electric revolution

Future flight

Clean growth Energy revolution

Transforming construction

Transforming food production

Industrial decarbonisation

Smart sustainable plastic packaging

Transforming Foundation Industries


Underpinning UKRI investments (Wave 1a) up to £283m

Leading-Edge Healthcare Challenge (including Medicines Mfg) up to £188m

National Satellite Test Facility up to £99m

Next Gen. Affordable Lightweight Materials Mfg (ATI projects) up to £26m

Autonomous Vehicles (CCAV projects) up to £38m

Robotics and AI in extreme environments Challenge up to £93m

Faraday Battery Challenge up to £246m

Wave 1 Challenges (c. £1bn)

9


Wave 2 Challenges (up to £729.5m)

Early diagnosis & precision med (up to £196m)

Healthy ageing (up to £98m)

Next generation services (up to £20m)

Audience of the future (up to £33m)

Quantum technology (up to £20m)

Transforming construction (up to £170m)

Transforming food production (up to £90m)

Energy revolution (up to £102.5m)

10

ICSF Medicines Manufacturing Challenge

Medicines Manufacturing Collaborative R&D

£25m

Advanced Therapies Treatment Centres

£30m

Cell & Gene Therapy Manufacturing Centre

£12m

Medicines Manufacturing Innovation Centre

£13m

Vaccines Development & Manufacturing Centre

£66m

Over £210m to develop first-of-a-kind technologies for the manufacture of medicines to accelerate patient access to new drugs and treatments

Digital Health Technology Catalyst

£35m

Viral vector production for

cell and gene therapies £5.6m

Digitalisation of medicines manufacturing

£4.3m

Medicines Manufacturing CR&D

•  12AdvancedTherapies

•  £10.2mgrantfunding+£3.6mco-funding•  10Medicineandtherapeuticdevelopment

•  £4.2mgrantfunding+£1.6mco-funding•  9Pharmaceuticalproductiontechnology

•  £5.2mgrantfunding+£2.4mco-funding



Building our

iMATCH

•  clinical delivery pathway •  informatics

•  end to end supply chain •  infrastructure •  economic modelling

•  track & trace solutions •  education

Advanced Therapy Treatment Centres

London ATN



Building ourATTC Network Projects

£3.3m funding to support network integration awarded in late 2018 Patient-Reported Outcomes assessment to support accelerated access to advanced cell and gene therapies: PROmics •  Total project costs of £1.4m with grant funding of £1.2m Standard Approach to atMP tissue colLEction (SAMPLE) •  Total project costs of £2.5m with grant funding of £2m



Building our

Funding Opportunities

Biomedical Catalyst

Any innovative solution to a health and care challenge £10m available, closes 3rd April 2019 Feasibility & Primer – up to 18 months and £1m total costs Early & Late – must end by March 2021 and £4m total costs

Feasibility Primer Early Late

Exploration&evaluationofthecommercialpotentialofascientificidea(deskorbench)

Technicalevaluationthroughtoproofofconceptinamodelsystem

Progressionofatechnicalevaluationuptothepointofreadinessforclinicaltesting

Demonstrationofeffectivenessinhumans,patients,orotherrelevantenvironment

Innovate UK Smart Grants: February 2019

Projects that support ambitious or disruptive R&D innovations with significant potential for impact on the UK economy £20m available, closes noon 24 April 2019 6 and 18 months •  total project costs between £25k and £500k •  single company or collaboration 19 and 36 months •  total project costs between £25k and £2m •  collaboration only https://apply-for-innovation-funding.service.gov.uk/competition/324/overview

SupportingUKinnovativebusinessestodayindevelopingtheindustriesoftomorrow

strategic support for advanced therapiesinnovate uk – advanced therapies building our in addition...

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