steven p. brown solid-state nmr research · steven p. brown solid-state nmr research collaborations...
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Steven P. Brown Solid-State NMR Research
Collaborations with AstraZeneca, Daiichi Sankyo, GlaxoSmithKline,Pfizer and Syngenta to characterise solid-state forms
CH2,CH3
δ DQ (1 H
) / p
pm
δSQ (1H) / ppm
H3
H2H15
H10
14 12 10 8 6 4 2 0δSQ (1H) / ppm
14 12 10 8 6 4 2 0
30
25
20
15
10
5
0
30
25
20
15
10
5
0
amount of cimetidinefree form in mixture
with salt
level of detectionis 1% w/w
0%
100%
10%5%1%
0.5%
N SNH
N
NH
CH3
NN
H
H
(NH+)
CH3
12
3 4
5
6
7
8
9 1011
1213
14
1516
24 20 16 12 8 4 0δSQ (1H) / ppm