steve haltiwanger aeon

LifeWave 2011 Aeon Conference

Steve Haltiwanger MD, CCN

Prolonged exposure to both physiological and psychosocial stress increases inflammation and the rate of aging among the body’s organ systems (Sapolsky, 1992).

A exposição prolongada ao stresse fisiológico e psicossocial aumenta a inflamação e a taxa de envelhecimento entre os sistemas de órgãos do corpo (Sapolsky, 1992).

Stress

ANS + Biochemical response

Silent Chronic Inflammation + Free radical damage

Cellular Dysfunction

Organ damageAging

Envelhecimento

ANS + Resposta bioquímica

Inflamação Crónica Silenciosa + Lesões dos radicais livres

Disfunção Celular

Lesões nos órgãos

Stress: the reaction of the body and mind to everyday challenges and demandsStress: a reação do corpo e da mente a desafios e exigências do dia-a-dia

Both psychological stress and aging activate the Sympathetic Nervous systemTanto o stresse psicológico como o envelhecimento activam o sistema Nervoso Simpático

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Time (x 30 sec)

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HR

Healthy profile

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“High parasympathetic tone”(Stress resilience)

“Low parasympathetic tone”

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www.nuigalway.ie/childandfamilyresearch/documents/CFRC2010-05-19.ppt

Aging increases the activity of the sympathetic nervous system, which in turn increases inflammation and oxidative stress. O envelhecimento aumenta a atividade do sistema nervoso simpático, que, por seu turno, aumenta a inflamação e o stresse oxidativo.

Perfil saudável

Unhealthy profileHR

Perfil não saudável

«Tom parassimpático elevado»(Resiliência ao stress)

«Tom parassimpático baixo»

Chronic stress leads to pain and fatigue. It also increases immune-mediated inflammation activating inflammatory chemicals, which affect the brain and evoke feelings of malaise, sickness and tiredness (Graham et al., 2006; Ho et al., 2010). O stresse crónico conduz a dor e fadiga. Também aumenta a inflamação relativa à imunidade activando químicos inflamatórios, que afetam o cérebro e motivam sentimentos de mal-estar, doença e cansaço (Graham et al., 2006; Ho et al., 2010).

Two of the consistent effects of Aeon patches have been reports of more energy and less pain.Dois dos efeitos consistentes dos adesivos Aeon têm sido os relatos de mais energia e menos dor.

Increased C-Reactive Protein Aumento da Proteína C-Reativa

Increased Fibrinogen Aumento do Fibrinogénio

Increased Homocysteine Aumento da Homocisteína

Increased Lipid Peroxides Aumento dos Peróxidos Lipídicos

Increase Cytokine Production with an Imbalance of Inflammatory Cytokines Aumento da Produção de

Citoquinas com um Desequilíbrio das Citoquinas Inflamatórias

Increase in damaged DNA Aumento do ADN danificado

Biochemical Markers of InflammationMarcadores Bioquímicos da Inflamação

“Chronic (daily), subclinical (invisible) inflammation sustained over a lifetime is the underlying cause of aging (Pugliese, 1991).”«A inflamação crónica (diária), subclínica (invisível) mantida ao longo da vida é a causasubjacente do envelhecimento (Pugliese, 1991).»

Oxidative stressInflammation

NormalAging

Accelerated Aging

Inflamação porstresse oxidativo

EnvelhecimentoNormal

Envelhecimen-to Acelerado

Silent persistent inflammation is responsible for many of the chronic diseases of aging. A inflamação silenciosa persistente é responsável por muitas das doenças crónicas do envelhecimento.

Chronic and continuous inflammation creates oxidative stress, immune system breakdown and communication errors where the body loses it’s ability to distinguish normal cells from foreign invaders. A inflamação crónica e contínua cria stresse oxidativo, quebra do sistema imunitário e erros de comunicação em que o corpo perde a capacidade de distinguir as células normais dos invasores externos.

When this occurs the body’s immune system will attack both healthy and injured cells, which will eventually lead to organ damage (Sinatra, 2004). Quando isto acontece o sistema imunitário do corpo ataca células saudáveis e danificadas, o que acaba por conduzir a lesões nos órgãos (Sinatra, 2004).

“Cumulative oxidative stress is believed to play a major role in the process of cellular aging (Zhou et al., 2008).”«Crê-se que o stresse oxidativo cumulativo tem um papel importante no processo de envelhecimento celular (Zhou et al., 2008).»

Chronic inflammation and oxidative stress causing lipid peroxidation (damage to cellular membranes) characteristically increase with age and are important factors in creating organ dysfunctions (Csiszar et al., 2007). A inflamação crónica e o stresse oxidativo que causam a peroxidação lipídica (lesão das membranas celulares) aumentam caracteristicamente com a idade e são importantes fatores na criação de disfunção nos órgãos (Csiszar et al., 2007).

EIS testing showed Aeon patches improved cellular physiologic function measurementsO teste EIS demonstrou que os adesivos Aeon melhoram os resultados da função fisiológica celular

Oxidative stress typically increases with age resulting from increasing free radical production and declining antioxidant defenses (Sastre et al., 2000).O stresse oxidativo aumenta tipicamente com a idade, devido ao aumento da produção de radicais livres e ao declínio das defensas dos antioxidantes (Sastre et al., 2000).

To me this means that using strategies to correct these concerns will be very beneficial in reducing cellular damage and organ deterioration. O stresse oxidativo aumenta tipicamente com a idade, devido ao aumento da produção de radicais livres e ao declínio das defensas dos antioxidantes (Sastre et al., 2000).

Aeon – should be used with Glutathione and Carnosine PatchesAeon – deve ser usado com os adesivos Glutathione e Carnosine

Oxidative stress damages and creates age-related degeneration in:O stresse oxidativo prejudica e cria degeneração relacionada com o envelhecimento nas:

Mitochondria Mitocôndrias

DNA ADN

Protein and Nas Moléculas de Proteína e

Lipid molecules (Weinert et al., 2003). Moléculas Lipídicas

Genetic damage increases with aging as the levels of oxidant-damaged DNA and protein accumulate (Beckman and Ames 1998).As lesões genéticas aumentam com a idade, à medida que se

acumulam os níveis de ADN e de proteína danificados pelos oxidantes (Beckman and Ames 1998).

stress

oxidative

inflammation

Cell and organ

damage

Aging

Aeon Patches

Moving into Parasympathetic

Reduces Stress

StressIncreasesAumenta

Sympathetic activity increases inflammatory chemicals.A atividade do sistema nervoso simpático aumenta os químicosinflamatórios. However controlling inflammation reduces tissue damage and improves quality of life. Porém, controlar a inflamação reduz a lesão nos tecidos e melhora a qualidade de vida.

Stress

Parasympathetic activity curbs sympathetic activity. A actividade do parassimpático limita a actividade do sistema nervososimpático. DHEA reduces oxidative stress and increases anti-inflammatory

signals.A DHEA reduz o stresse oxidativo e aumenta os sinais anti-inflamatórios.

Fibrinogen, a protein made by the liver, may rise sharply in any condition that causes inflammation or tissue damage.O fibrinogénio, uma proteína produzida pelo fígado, pode subir

rapidamente em qualquer condição que cause inflamação ou lesão nos tecidos.

A high fibrinogen level is significantly associated with coronary artery disease, carotid atherosclerosis and strokes (De Luca et al., 2010; Kwaan, 2010).Um alto nível de fibrinogénios está significativamente associado àdoença da artéria coronária, à aterosclerose da carótida e aos derramescerebrais (De Luca et al., 2010; Kwaan, 2010).

These conditions cause 60% of the deaths in the elderly.Estas condições causam 60% das mortes dos idosos.

High fibrinogen levels can cause a heart attack or stroke via several mechanisms, including increased blood clots and excessive blood thickening. Elevados níveis de fibrinogénios podem provocar um ataque cardíaco ou derrame cerebral através de diversos mecanismos, incluindo o aumento de coágulos sanguíneos e o excessivo espessamento do sangue.

The New England Journal of Medicine studies showed that those with high levels of fibrinogen were more than twice as likely to die of a heart attack. lef.orgOs estudos do New England Journal of Medicine demonstraram que as pessoas com elevados níveis de fibrinogénio tinham mais do dobro das probabilidades de morrer de ataque cardíaco. lef.org

A team of scientists in China compared fibrinogen levels in two family groups, 7 families with a history of long life, compared to 9 families with traditionally shorter life expectancies. Uma equipa de cientistas da China compararam os níveis de fibrinogénio de dois grupos familiares, 7 famílias com uma história de longevidade, em comparação com 9 famílias com uma esperança de vida tradicionalmente mais curta.

The scientists concluded that low plasma fibrinogen levels are correlated with longer life (Wang, et al, 1998). Os cientistas concluíram que os níveis baixos de fibrinogénio do plasma estão relacionados com uma vida mais longa (Wang, et al, 1998).

Aeon testing showed a trend of lower fibrinogen levelsTestes feitos ao Aeon mostraram uma tendência para baixos níveis de fibrinogénio

Elevated C-reactive protein (CRP) is a biochemical marker of underlying chronic inflammation (Vasović et al., 2010).A proteína C-reativa elevada (CRP) é um marcador bioquímico de inflamação crónica subjacente (Vasović et al., 2010).

C-reactive protein is often sharply elevated in aged people with multiple degenerative diseases. A proteína C-reativa sobrefrequentemente um aumento abrupto em idosos com doenças de denegeração múltipla.

Systemic chronic inflammation plays a central role in age-related diseasesA inflamação crónica sistémica desempenha um papel central nasdoenças associadas à idade

“People with high levels of CRP, one of the cardinal markers of inflammation, were over four times more likely to have heart attacks than those with low levels of CRP (Sinatra, 2004).” «Pessoas com a CRP alta, um dos marcadores essenciais de inflamação, tinham quatro vezes mais probabilidades de sofrer ataquescardíacos do que as que tinham níveis baixos de CRP (Sinatra, 2004).”

Aeon testing showed a trend of lower CRP levelsTestes feitos ao Aeon mostraram uma tendência para níveis de CRP baixos

Varying degrees of high levels of homocysteine are detectable in all inflammatory diseases and it is a marker for inflammation (Wu, 2007). Diversos graus de níveis elevadosde homocisteína são detetáveis em todas as doenças inflamatórias, e este é um marcador da inflamação (Wu, 2007).

High homocysteine Homocisteína elevada

Acute and ChronicInflammationInflamação Agudae Crónica

Via Oxidative

stress

Organs most affected by chronic inflammation:Órgãos mais afetados pela inflamação crónica: Brain Cérebro

Heart Coração

Kidneys Rins

Lungs Pulmões

Arteries Artérias

Homocysteine-induced oxidative stress:Stresse oxidativo induzido pela homocisteína:

Damages blood vessels. Danifica os vasos sanguíneos.

Favors lipid peroxidation and Favorece a peroxidação lipídica e

Induces production of inflammatory factors (Lin et al., 2009). Induz a produção de fatores inflamatórios

InflammationInflamação

OxidationOxidação

AgingEnvelhecimento

Aeon testing showed a trend of lower homocysteine levels – showing an impact on both I & OTestes feitos ao Aeon demonstraram níveis tendencialmente mais baixos de homocisteína – mostrando um impacto na I & O

The level of lipid peroxides is a measure of cellular membrane damage caused by the action of free radicals (Miquel et al., 1998).O nível de peróxidos lipídicos permite medir a lesão na membranacelular devido à ação dos radicais livres (Miquel et al., 1998).

The elevation of lipid peroxides is an early warning of the potential long-term effects of oxidative stress. O aumento de peróxidos lipídicos é um aviso prévio de potenciaisefeitos de stresse oxidativo a longo-prazo.

The outcome of long-term oxidative stress is chronic degenerative disease (Halliwell et al., 1993).O resultado do stresse oxidativo a longo-prazo é a doençadegenerativa crónica

Why are lipid peroxides important?Porque são os peróxidos lipídicos importantes?

The concentration of lipid peroxides progressively increase with age (Bhagwat, 1997). A concentração de peróxidos lipídicos aumenta progressivamente com a idade (Bhagwat, 1997).

This is a reflection of accumulating oxidative stress and impaired antioxidant defenses. Isso é um reflexo do acumular do stresse oxidativo e da diminuição das defesas antioxidantes.

Damage to the structures of cell membrane lipid molecules lead to changes in their:As lesões nas estruturas das moléculas lipídicas da membrana celularlevam a mudanças na sua: Permeability Permeabilidade

Transport mechanisms and Mecanismos de transporte e

Communication signaling. Sinalização da comunicação.

This disrupts many cellular processes Isto perturba muitosprocessos celulares

Aeon testing showed a trend of lower lipid peroxide levels Testes feitos ao Aeon testing demonstraram níveis tendencialmente mais baixos de peróxido lipídico

Mitochondrial Insufficiency Insuficiência Mitocondrial

Since inflammation has destructive effects on the mitochondria, reducing inflammation will protect the mitochondria.Como a inflamação tem efeitos destrutivos nas mitocôndrias, reduzir a inflamação irá proteger as mitocôndrias.

Remember the mitochondria are the energy plants of the cell.Recordemos que as mitocôndrias são as fábricas de energia das células.

Aeon patches have been reported to increase energyTem sido referido que os adesivos Aeon aumentam a energia

Reduction of Inflammation by AeonRedução da Inflamação através do Aeon

Based on our lab study, use of Aeon patches results in the following changes in mediators of inflammation:Com base no nosso estudo laboratorial, o uso dos adesivos Aeon resulta nas seguintes mudanças nos mediadores da inflamação:

Decreased C-Reactive Protein LevelsRedução dos Níveis de Proteína C-Reativa

Decreased Fibrinogen levelsRedução dos níveis de Fibrinogénios

Decreased Homocysteine levelsRedução dos níveis de Homocisteína

Decreased Lipid Peroxide levelsRedução dos níveis de Peróxidos Lipídicos

Antioxidants + Anti-inflammatories

Glutathione

Carnosine

Aeon

Are Protective

Aeon reduces stress as measured by increased activity of the parasympathetic nervous system. O Aeon reduz o stresse medido pelo aumento da atividade do sistema nervosoparassimpático.

Aeon patches reduce the biochemical markers of inflammation that cause tissue and organ damage.Os adesivos Aeon reduzem os marcadores bioquímicos da

inflamação que causam lesões em tecidos e órgãos.

By reducing tissue and organ damage we can reduce the wear and tear associated with aging – NOW.Reduzindo os danos em tecidos e órgãos podemos reduzir o desgaste associado ao envelhecimento – AGORA.

Take HomeResumo

1. Anti-aging therapeutics, Volume 6 Eds. Klatz R, Goldman B. Chapter 4: Sinatra S. “Fire in the Heart”: New Developments in Diagnosis, Prevention & Treatment of Cardiovascular Disease. 2004, pgs 27-45. Chicago, American Academy of Anti-aging Medicine

2. Melo RC, Santos MDB, Silva E, et al. Effects of age and physical activity on the autonomic control of heart rate in healthy men. Braz J Med Biol Res. September 2005;38(9):1331-1338.

3. Csiszar A, Toth J, Peti-Peterdi J et al. The aging kidney: role of endothelial oxidative stress and inflammation. Acta Physiologica Hungarica. 2007; 94: 107–115.

4. Zhou XJ, Rakheja D, Yu X, et al. The aging kidney. Kidney Int. 2008 Sep;74(6):710-20.5. Sastre J, Pallardo FV, Garcia de la Asuncion J, et al. Mitocondria, oxidative stress and aging.

Free Rad Res. 2000;32:189–98.6. Weinert BT, Timiras PS. Theories of aging. J Appl Physiol. 2003;95:1706–16.7. De Luca G, Verdoia M, Cassetti E, et al. High fibrinogen level is an independent predictor of

presence and extent of coronary artery disease among Italian population. J Thromb Thrombolysis. 2010 Nov 16.

8. Vasović O, Trifunović D, Despotovié N, et al. Chronic low-grade inflammation, lipid risk factors and mortality in functionally dependent elderly. Vojnosanit Pregl. 2010 Jul;67(7):562-8.

9. Kwaan HC. Role of plasma proteins in whole blood viscosity: a brief clinical review. Clin Hemorheol Microcirc. 2010;44(3):167-76.

10. Wang X, Wang G, Yang C, Li X. Comparison of plasma fibrinogen level in members of Uygur family of longevity and non-longevity in Xinjiang. Wei Sheng Yan Jiu. 1998 Sep 30;27(5):315-6, 327.

11. Ho RC, Neo LF, Chua AN, Cheak AA, Mak A. Research on psychoneuroimmunology: does stress influence immunity and cause coronary artery disease? Ann Acad Med Singapore. 2010 Mar;39(3):191-6.

12. Graham JE, Robles TF, et al. Hostility and pain are related to inflammation in older adults. Brain Behav Immun. 2006 Jul;20(4):389-400.

13. Finch JM, Joseph J. Homocysteine, Cardiovascular Inflammation, and Myocardial Remodeling. Cardiovasc Hematol Disord Drug Targets. 2010 Nov 11.

14. Lin CP, Chen YH, Leu HB et al. Anti-inflammatory strategies for homocysteine-related cardiovascular disease. Front Biosci. 2009 Jan 1;14:3836-45.

15. Wu JT. Circulating homocysteine is an inflammation marker and a risk factor of life-threatening inflammatory diseases. J Biomed Lab Sci. 2007;19(4):107-112.

16. Miquel J, Ramirez-Boscá A, Soler A, et al. Increase with age of serum lipid peroxides: implications for the prevention of atherosclerosis. Mech Ageing Dev. 1998 Jan 12;100(1):17-24.

17. Bhagwat VR. Relationship of erythrocyte superoxide dismutase, serum lipid peroxides and age. Indian J Med Sci. 1997 Feb;51(2):45-51.

18. Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr. 1993 May;57(5 Suppl):715S-724S.

19. Sapolsky R M. Stress, the aging brain, and the mechanism of death. Cambridge, MA: MIT Press, 1992.

20. Pugliese PT. Advanced Professional Skin Care. APSC Publishing, 1991

Y-Age Aeon Basic Protocol

Rotate through the point locations shown, using an Aeon patch 5-7 days per

week. The recommended point locations for Y-Age Aeon follow, but you can

experiment with these point locations for Y-Age Glutathione and Y- Age

Carnosine as well.

Option 1: Conception Vessel 6 (CV6)

Location: On the midline of the abdomen,

1.5 cun (the length of the index and middle

fingers) below the belly button.

Option 2: Governing Vessel 14 (GV14)

Location: At the base of the back of the

neck, where the C7 vertebra protrudes if

you tuck your chin to your chest

Option 3: Kidney 3 (KI3) Location: In the

depression just behind the inside ankle

bone

Option 4: Large Intestine 4 (LI4)

Location: On the back of the hand, in the

web, on the bone of the index finger

Option 5: Liver 3 (LV3)

Location: On the top of the foot, in the

web of the big toe

Y-Age Advanced Protocols and Combinations

Aging is a complex process resulting from a number of different factors.

Therefore, an effective anti-aging strategy must be a comprehensive one that

tackles the various causes of aging. Each element of the Y-Age system is

designed to provide its own unique anti-aging benefit. Using these patches in

combination with one another enhances the affects of each individual product

and provides a more complete defense against aging.

Keep the following guidelines in mind when combining Y-Age patches:

Frequency of Use

• Y-Age Glutathione – Five to seven days per week

• Y-Age Carnosine – One to three days per week

• Y-Age Aeon – Five to seven days per week

Wear any TWO patches together on any day of the week on any TWO

recommended Y-Age patch locations. Use muscle testing to determine the

placements and patches that work best for you.

Note: Some people experience strong detoxification symptoms when wearing more than one Y-Age

patch at a time. Additionally, some people experience feelings of fatigue when wearing Carnosine or

Aeon during the day. With Aeon, this often occurs because the patch has shifted the Central Nervous

System to the parasympathetic. If you fall into this category, you may want to consider taking Aeon off

for a few hours and wearing Carnosine in the evening only.

Basic Recommended Y-Age Patch Locations

• Conception Vessel 6

• Conception Vessel 22

• Governing Vessel 2

• Governing Vessel 14

• Heart 7

• Kidney 3

• Large Intestine 4

• Liver 3

• Lung 9

• Spleen 6

Y-Age 7 Day Protocol

Alternatively, you can choose to follow the recommended Y-Age protocol below

for combining all the Y-Age patches.

Glutathione and Aeon should be worn during the day (12 hours), seven days per

week. Carnosine should be worn at night only; seven days per week.

Y-Age 7 Day Protocol Point Locations

Bladder 60 Conception Vessel 6

Y-Age 7 Day Protocol Point Locations (Continued)

Conception Vessel 17 Gallbladder 41


Governing Vessel 14 Kidney 1


Kidney 3 Kidney 27


Large Intestine 4 Liver 3


Lung 9 Pericardium 6


Spleen 4 Spleen 6


Spleen 21 Stomach 36


Triple Burner 5

Energy Enhancer & Y-Age Aeon

In the following protocols, the Energy Enhancer patches promote the flow of

energy through the body; while the Aeon patches balance this flow of energy

and promote and anti-stress response.

Energy Enhancer & Y-Age Aeon (continued).

Combining Y-Age Aeon and IceWave

If you do not find pain relief with IceWave alone, you can try applying an Aeon

patch at the midline of the body to enhance the effects of IceWave. This applies

whether you are dealing with all over body pain or with a specific area of pain.

To use this approach, first apply IceWave according to one of the basic

protocols found in the IceWave brochure (i.e., Clock Method, Bracketing Method

or one of the placements for whole body pain). Then apply an IceWave patch at

one of the recommended points below:

Combining Y-Age Aeon and IceWave (continued)

Governing Vessel 14 Governing Vessel 4

Combining Y-Age Aeon and IceWave (continued)

Conception Vessel 17 Over the Belly Button

steve haltiwanger aeon

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