stem cells and cell therapy homeostasis - tumor - neuronal ...€¦ · regenerative medicine 7 this...

News 8/2013 Biomedicine

39

M. Al-Rubeai, M. Naciri, University College Dublin, Ireland (Eds)

Stem Cells and Cell TherapyWith the discovery of stem cells capable of multiplying indefinitely in culture and differen-tiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The fea-tures of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells.

Features 7 This is the first book of its kind to offer an advanced understanding of the latest technologies in stem cell expansion and manufacturing 7 This is a book designed specifically to provide power-ful research opportunities for those interested in perusing work in large scale production of stem cells for clinical application 7 This book is spe-cially formatted so that it is not only a source on stem cell biology and therapeutic application but also a good foundation for understanding basic regenerative medicine 7 This book is a valuable reference resource for both experienced investiga-tors in stem cell therapy as well as those in cell culture, bioengineering, tissue engineering and developmental biology fields

Contents Use of Human Embryonic Stem Cells in Therapy.- Human Neural Stem Cell-based Cell- and Gene-therapy for Neurological Diseases.- Vascular Stem Cell Therapy.- Bioprocessing of Human Pluripo-tent Stem Cells for Cell Therapy Applications.- Blood Cell Bioprocessing: The Haematopoietic System and Current Status of In-vitro Production of Red Blood Cells.- Bioprocessing Challenges Associated with the Purification of Cellular Therapies.- Separation Technologies for Stem Cell Bioprocessing.

Fields of interestBiomedicine general; Cell Biology; Stem Cells

Target groupsResearch

Product categoryContributed volume

Due September 2013

2013. VII, 180 p. 24 illus., 22 in color. (Cell Engineering, Volume 8) Hardcover7 $189.00ISBN 978-94-007-7195-6

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S. Amini, Temple University College of Science & Technology, Philadelphia, PA, USA; M. K. White, Temple University School of Medicine, Philadelphia, PA, USA (Eds)

Neuronal Cell CultureMethods and Protocols

In Neuronal Cell Culture: Methods and Protocols, the latest aspects of the culture of neural cells are explored by experts in the field who also explain the practical and theoretical considerations of the techniques involved.

Features 7 Covers the latest aspects of the culture of neu-ral cells 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents General Overview of Neuronal Cell Culture.- Considerations for the Use of SH-SY5Y Neu-roblastoma Cells in Neurobiology.- Cultured Cell Line Models of Neuronal Differentiation: NT2, PC12.- Murine Teratocarcinoma-Derived Neuronal Cultures.- Isolation and Propagation of Primary Human and Rodent Embryonic Neural Progenitor Cells and Cortical Neurons.- Mouse Enteric Neuronal Cell Culture.- Preparation of Neural Stem Cells and Progenitors: Neuronal Production and Grafting Applications.- Deriva-tion of Neuronal Cells from Fetal Normal Human Astrocyte (NHA).- Slice Culture Modeling of Central Nervous System (CNS) Viral Infection.- Neurospheres and Glial Cell Cultures: Immuno-cytochemistry for Cell Phenotyping.- Transfection of Neuronal Cultures.- Lentiviral Transduction of Neuronal Cells.- Compartmentalized Neuronal Cultures.- Quantitative Assessment of Neurite Outgrowth Over Growth Promoting or Inhibitory Substrates.

Fields of interestNeurosciences; Neurobiology; Cell Culture

Target groupsProfessional/practitioner


Due September 2013

2013. X, 182 p. 38 illus., 31 in color. (Methods in Molecular Biology, Volume 1078) Hardcover7 $189.00ISBN 978-1-62703-639-9

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G. Banfalvi, University of Debrecen, Debrecen, Hungary

Homeostasis - Tumor - MetastasisHomeostasis. The health of an organism is influ-enced by external and internal changes that may lead to the loss of homeostasis. Under healthy conditions organisms compensate these changes. If compensation fails disease ensues. Attention will be paid to lifestyle, environmental changes, genetic makeup and health system. It will be answered how lifestyle, environment, genetic makeup and social conditions help to maintain or upset the biological balance and lead to cancer. Tumor formation. To understand this process the transfer of intracellular and the pathways of extracellular information (signal transduction) will be reviewed briefly. Loss of cellular balance may lead to cell death (.e.g. apoptosis) or to rapid cell growth of cells leading to tumor formation. Metastasis.

Features 7 First the reader will learn about maintaining homeostasis, then about loss of health by upsetting the biological balance 7 The consequence of unbalanced cell growth helps to understand cell death and tumor formation 7 Readers will get an idea how primary tumors cells confined to re-stricted areas in the body can be effectively treated without cancerous consequences 7 Old (he-matogen) and new theories (lymphatic) will help the understanding of metastatic spread of tumors

Contents Preface.- Homeostasis.- Cell cultures.- Loss of homeostasis.- Tumor development.- Metastasis.- References.- Abbreviations.

Fields of interestCancer Research; Cell Biology; Biomedicine general


Product categoryMonograph

Due August 2013

2013. XVI, 250 p. 71 illus., 16 in color. Hardcover7 $189.00ISBN 978-94-007-7334-9

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www.springer.com/978-94-007-7195-6



Biomedicine springer.com/NEWSonline

40

S. Bhattacharya, MIAMI, FL, USA; A. Nicholas, University of Alabama at Birmingham, Birmingham, AL, USA (Eds)

Protein Deimination in Human Health and DiseaseContents Physiological pathways of PAD activity and citrul-linated epitope generation.- from citrullination to specific immunity and disease in rheumatoid arthritis.- The role of citrullinated proteins in the pathophysiology of rheumatoid arthritis.- Protein citrullination: the link between rheumatoid arthri-tis and periodontitis?.- From genes and environ-ment to anti-culture immunity in rheumatoid arthritis: The role of the lungs.- Neutrophils and their contribution to autoimmunity in rheumatoid arthritis.- Deimination in skin and regulation of PAD expression in keratinocytes.- Importance of citrullination on hair protein molecular assembly during trichocytic differentiation.- Deimination in the peripheral nervous system: A wallflower existence.- Deimination in multiple sclerosis and experimental autoimmune encephalo-myelitis.- Protein hypercitrullination in CNS demyelinating disease reversed by PAD inhibi-tion.- Deimination in prion diseases.- Deimina-tion in Alzheimer’s disease.- Ongoing studies of deimination in neurodegenerative diseases using the F95 antibody.- The role of protein deimination in epigenetics.- Identifying citrullination sites by mass spectroscopy.- Homocitrulline—an analogue and confounder related to citrulline.- Picking the PAD lock: Chemical and biological approaches to identify PAD substrates and inhibitors.

Fields of interestNeurosciences; Neurochemistry; Ophthalmology



Due October 2013

2013. IV, 373 p. 131 illus., 71 in color. Hardcover7 $209.00ISBN 978-1-4614-8316-8

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A. R. Brasier, University of Texas Medical Branch, Galveston, TX, USA (Ed)

Heterogeneity in AsthmaContents Introduction: Applications of Translational Sci-ence to Clinical Problems.- Section I: Spectrum of Asthma.- Introduction to spectrum of asthma.- 1. Introduction to Asthma and Phenotyping.- 2. Epidemiology of Asthma.- 3. Heterogeneity of asthma in society.- 4. Allergens and Environmen-tal Association to Asthma.- 5. Current Clinical Diagnostic Tests for Asthma.- 6. Management of Asthma: the current US and European Guide-lines.- 7. Community Interventions in Asthma.- 8. Heterogeneity of Response to Therapy.- Section II: Genetics and Genomics in Asthma.- Introduction to genetics and genomics in asthma.- 9. Genet-ics of Asthma.- 10. Genomics of Asthma.- 11. Epigenetics of Asthma.- Section III: Proteomics, Metabolomics, and Systems Biology of Asth-ma.-11. Introduction to proteomics, metabolomics and systems biology of asthma.- 12. Overview of Proteomics in Airway Disease.- 13. Metabolomics in Asthma.- 14. Overview on Methods of Sample Preparation.- 15. Measurement of Innate Im-munity in the Airway.- 16. Functional Proteomics in Isolated Cells for Steroid Response.- Section IV: Modeling Complex Data in Asthma.- Introduc-tion to modeling complex data in asthma.- 17. Biostatistical Analysis and Predictive Modeling in Asthma Phenotype.- 18. Role of Visual Analyt-ics in Asthma Phenotyping and Complex Data Analysis.- Section V: Biobehavioral Determinants in Asthma.- Introduction to biobehavioral deter-minants.- 19. Central Nervous System Influences in Asthma.- 20. Social and Cultural Influences in Asthma Diagnosis and Management.- Section VI: Conclusions and Future Directions.- Summary

Fields of interestHuman Physiology; Molecular Medicine



Due September 2013

2013. Approx. 250 p. 29 illus., 22 in color. (Advances in Experimental Medicine and Biology, Volume 795) Hardcover7 $189.00ISBN 978-1-4614-8602-2

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S. Caccio, Istituto Superiore di Sanità, Rome, Italy; G. Widmer, Tufts Cummings School of Veterinary Medi Division of Infectious Diseases, North Grafton, MA, USA (Eds)

Cryptosporidium: parasite and diseaseFeatures 7 Gives an up to date overview to all aspects of parasite biology and disease symptoms in cryptosporidiosis 7 Describes molec ular biol-ogy, epidemiology and host-parasite interaction in detail 7 Provides information on diagnosis, symptoms and treatment for physicians and veterinarians

Contents Section 1: Taxonomy and epidemiology of Crypto-sporidium.- Taxonomy and molecular taxonomy.- General epidemiology, including waterborne and foodborne transmission.- Molecular epidemiol-ogy of human infections (appendix: molecular protocols for parasite detection and genotyping).- Cryptosporidiosis in farm animals.- Cryptospo-ridiosis in other vertebrates.- Section 2: Molecular biology and genomics.- Genomics and compara-tive genomics (appendix: databases and other bioinformatic resources).- Gene expression and regulation.- Cryptosporidium metabolism.- Sec-tion 3: Host-parasite interaction.- Host-parasite interaction.- Clinical cryptosporidiosis.- Im-munology of cryptosporidiosis.- Treatment of cryptosporidiosis.- Section 4: Cryptosporidium and the water.- Cryptosporidium in drinking and recreational water (appendix: method for recovery and identification of Cryptosporidium from water).- Removal and inactivation of Cryptospo-ridium from water.

Fields of interestParasitology; Veterinary Medicine; Infectious Diseases



Due December 2013

2014. Approx. 350 p. 55 illus., 15 in color. Hardcover7 approx. $209.00ISBN 978-3-7091-1561-9

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41

D. Coppola, Moffitt Cancer Center, Tampa, FL, USA (Ed)

Molecular Pathology and Diagnostics of CancerFeatures 7 The book is designed to provide a quick reference for the management of pathology cases requiring molecular testing 7 It includes a detailed description of sophisticated molecular tests 7 It explains how the molecular pathology results will guide to the correct diagnosis and will affect patient care

Contents Preface.- Molecular Pathology and Diagnostics of Gliomas.-Molecular Pathology and Diagnostics of Thyroid and Parathyroid Malignancies.- Molecular Pathology and Diagnostics of Breast Cancer.- Mo-lecular Pathology and Diagnostics of Non-Small Cell Lung Carcinoma.- Molecular Pathology and Diagnostics of Colorectal Cancer.- Molecular Pathology and Diagnostics in Esophago-Gastric Cancer.- Molecular-Genetic Testing in He-patocellular Carcinoma and Its Premalignant Conditions.- Molecular Diagnostics of Pancreatic Cancer.- Molecular Pathology and Diagnostics of Prostate Cancer.- Molecular Diagnosis of Bladder and Kidney Cancer.- Molecular-Genetic Testing in Penile, Scrotal, and Testicular Cancer.- Mo-lecular Pathology and Diagnostics of Gynecologic Malignancies.- Molecular Pathology of Bone and Soft Tissue Neoplasms and Potential Targets for Novel Therapy .- Molecular Pathology and Diag-nostics of Pancreatic Endocrine Neoplasms.- Mo-lecular Pathology and Diagnostics of Childhood Tumors.- Molecular Pathology and Diagnostics of Cutaneous Malignancy.- Molecular Diagnostics of Lymphoid Neoplasms.- Molecular Diagnostics of Myeloid Neoplasms.

Fields of interestCancer Research; Pathology; Biomedicine general



Due September 2013

2014. III, 633 p. 30 illus., 20 in color. (Cancer Growth and Progression, Volume 16) Hardcover7 $209.00ISBN 978-94-007-7191-8

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B. Eyden, S. S. Banerjee, Christie NHS Foundation Trust, Manchester, UK; Y. Ru, Institute of Hematology and Blood Diseas, Tianjin, China, People’s Republic; P. Liberski, School of Medicine, Łódź, Poland

The Ultrastructure of Human TumoursApplications in Diagnosis and Research

The Ultrastructure of Human Tumours: Applica-tions in Diagnosis and Research describes the core features as seen by transmission electron microscopy, defining the different types of cellular differentiation in tumours; this is relevant for tumour nomenclature and diagnosis, which, in turn, are important for tumour pathologists in their collaboration with oncologists for the treat-ment of cancer patients. The book is divided into 8 chapters.

Features 7 A comprehensive volume of electron micro-graphic images of human tumours 7 Set in the context of classical light microscopy-based pathology, and designed to help tumour patholo-gists achieve greater diagnostic precision 7 Ul-trastructural images of new, recently described variants of tumours, not documented in previ-ously published ultrastructural pathology mono-graphs 7 Insights into tumour cell structure and function

Contents Epithelial Tumours, Especially Carcinoma Squamous and Glandular Differentiation.- Ma-lignant Melanoma.- Soft-Tissue/Mesenchymal/Spindle Cell Tumours.- Tumours of the Nervous System.- Haematolymphoid Neoplasia.- Tumours of Complex or Uncertain Differentiation.

Fields of interestCancer Research; Biological Microscopy; Pathol-ogy


Product categoryAtlas

Due November 2013

Jointly published with Zhejiang University Press

Distribution rights for China: Zhejiang University Press

2014. Approx. 680 p. 757 illus. Hardcover7 approx. $219.00ISBN 978-3-642-39167-5

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M. Fabbri, University of Southern California Children’s Hospital Los Angeles, Los Angeles, CA, USA (Ed)

Non-coding RNAs and CancerThis book will comprehensively cover the most updated knowledge on the role of non-coding RNAs in human cancer. The Reader will be guided from the definition of what non-coding RNAs are to the translational and therapeutic implications of these fascinating molecules for cancer patients, through some of the most important discoveries clarifying the role of non-coding RNAs in human carcinogenesis.

Features 7 Examines recently identified gene regulatory mechanisms involving non-coding RNAs 7 Pro-vides essential information of the biogenesis, physiology and de-regulation of non-coding RNAs in cancer 7 Guides the reader to the most widely and effectively used bioinformatic approaches to the study of miRNAs

Contents Introduction.- Biogenesis and Physiology of microRNAs.-Detecting non-coding RNA expres-sion: from arrays to next generation sequenc-ing.- MicroRNAs in Solid Tumors.-MicroRNAs in hematologic malignancies.- miRNAs as Cancer Biomarkers.- Unraveling the complex network of interactions between non-coding RNAs and epigenetics in cancer.- MicroRNA SNPs in Can-cer.- Bioinformatics Approaches to the study of microRNAs.- Beyond miRNAs: role of other non-coding RNAs in cancer.- Translational Implica-tions for non-coding RNA in Cancer.- Index.

Fields of interestCancer Research; Cell Biology; Biochemistry, general



Due September 2013

2013. VI, 240 p. 19 illus. in color. Hardcover7 $189.00ISBN 978-1-4614-8443-1

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42

S. C. Frost, R. McKenna, University of Florida, Gainesville, FL, USA (Eds)

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial ApplicationsContents Preface. Part I Introduction.- Overview of the Carbonic Anhydrase Field.- Part II Carbonic Anhydrases: Ancient but Relevant. Physiological Functions of the Alpha Class of Carbonic Anhy-drases.- Catalytic Mechanism of α-Class Carbonic Anhydrases: CO2 Hydration and Proton Transfer.- Structure and Catalytic Mechanism of b-Carbonic Anhydrases.- Prokaryotic Carbonic Anhydrases of Earth’s Environment.- Carboxysomal Carbonic Anhydrases.- Carbonic Anhydrases and their In-terplay with Acid/base-coupled Membrane Trans-porters.- Carbonic Anhydrase Related Proteins: Molecular Biology and Evolution.- Membrane Associated Carbonic Anhydrase IV (CA IV): A Personal and Historical Perspective.- Carbonic Anhydrase Expression in Kidney and Renal Can-cer: Implications for Diagnosis and Treatment.- Carbonic Anhydrase IX: Regulation and Role in Cancer.- Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metasta-ses.- Carbonic Anhydrase IX (CAIX) as a Media-tor of Hypoxia-induced Stress Response in Cancer Cells.- Carbonic Anhydrases and Brain pH in the Control of Neruronal Excitability.- Carbonic An-hydrase Inhibitors: Drug Design.- Natural Prod-ucts that Inhibit Carbonic Anhydrases.- Glaucoma and the Application of Carbonic Anhydrase Inhibitors.- Carbonic Anhydrase Inhibitors and High Altitude Illnesses.- Thermal-Stable Carbonic Anhydrases: A Structural Overview.- Carbonic Anhydrases in Industrial Applications. Index.

Fields of interestGene Function; Protein Science; Biomedicine general



Due September 2013

2013. XII, 425 p. 75 illus., 37 in color. (Subcellular Biochemistry, Volume 75) Hardcover7 $209.00ISBN 978-94-007-7358-5

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R. Gieschke, D. Serafin, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Development of Innovative Drugs via Modeling with MATLABA Practical Guide

The development of innovative drugs is becom-ing more difficult while relying on empirical approaches. This inspired all major pharmaceuti-cal companies to pursue alternative model-based paradigms. The key question is: How to find inno-vative compounds and, subsequently, appropriate dosage regimens?

Features 7 Provides concepts for the creation of drug-disease models 7 Written from the industry perspective 7 Based on many years of experience

Contents Background of pharmacologic modeling.- First example of a computational model.- Differen-tial equations in MATLAB.- Pharmacologic modeling.- Drug-disease modeling.- Population analyses.- Clinical trial simulation.- Graphics-based modeling.- Outlook.- Appendix A: Hints to MATLAB programs.- Appendix B: Solution to exercises.

Fields of interestPharmacology/Toxicology; Pharmaceutical Sci-ences/Technology; Simulation and Modeling



Due September 2013

2013. XIV, 446 p. 192 illus., 112 in color. Hardcover7 $209.00ISBN 978-3-642-39764-6

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M. Giese, Institute for Molecular Vaccines, Heidelberg, Germany (Ed)

Molecular VaccinesFrom Prophylaxis to Therapy - Volume 1

This book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacte-rial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clini-cians interested in new developments in molecular vaccine research and application in infections and cancer.

Features 7 Provides detailed insight to basic vaccine immunology 7 Discusses different aspects of cancer vaccines 7 Explains how to use molecular vaccines in infectious diseases

Contents Molecular vaccines - from prophylaxis to therapy.- Vaccine immunology.- Vaccines for infectious diseases.- Cancer vaccines.

Fields of interestVaccine; Immunology; Molecular Medicine



Due August 2013

2013. VI, 430 p. 87 illus., 79 in color. Hardcover7 $209.00ISBN 978-3-7091-1418-6

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43


Molecular VaccinesFrom Prophylaxis to Therapy - Volume 2

This title discusses all aspects of non-infectious and non-cancer– so called NINC – vaccines. Hy-pertension, diabetes and allergy vaccine develop-ment are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclini-cal to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Administration) guidelines are described in-depth. The book is therefore of interest for researchers and clinicians engaged in vaccine development and molecular vaccine application.

Features 7 Reviews aspects of NINC vaccine develop-ment 7 Illustrates the complete process of vac-cine development from bench to preclinical and clinical studies and launch to the market 7 En-riches understanding of the use of nanotechnology in vaccine development

Contents Non-infectious and non-cancer vaccines.- Adju-vants and nanotechnology.- In silico and delivery systems.- Patenting, manufacturing, registration.




Due September 2013

2013. XV, 474 p. 92 illus., 69 in color. Hardcover7 $209.00ISBN 978-3-319-00977-3

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Molecular VaccinesFrom Prophylaxis to Therapy

The set of two volumes gives an detailed insight to all aspects of molecular vaccine development and application. Volume one provides a compre-hensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the complex topic of cancer vaccines is discussed in detail. Volume two discusses all aspects of non-infectious and non-cancer– so called NINC – vaccines. Hypertension, diabetes and allergy vaccine development are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclinical to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Ad-ministration) guidelines are described in-depth. Molecular Vaccines from Prophylaxis to Therapy is of interest for researchers and clinicians engaged in molecular vaccine development and applica-tion.

Features 7 Provides detailed insight to the basic vaccine immunology 7 Explains how to use molecular vaccines in infectious diseases and cancer 7 Il-lustrates the complete process of vaccine develop-ment from bench to preclinical and clinical studies and launch to the market 7 Enriches under-standing of the use of nanotechnology in vaccine development




Due November 2013

2014. 750 p. 800 illus., 200 in color. (2-volume-set)7 $279.00ISBN 978-3-319-01142-4

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P. Gopalakrishnakone, National University of Singapore, Singapore, Singapore (Ed)

Handbook of ToxinologyBiological Toxins and Bioterrorism

In recent years, the field of Toxinology has ex-panded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the bio-chemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential.

Features 7 Complete and comprehensive overview of tox-inology 7 Written by a very large team of experts from all around the world 7 Covers all areas of toxinology, including topics like bioterrorism, toxin evolution and toxin based drug development

Fields of interestBiomedicine general; Pharmacology/Toxicology; Pharmaceutical Sciences/Technology


Product categoryReference work

Due August 2014

Print

2015. 550 p. 30 illus., 15 in color. (Handbook of Toxinology, Volume 1) 7 $360.00ISBN 978-94-007-5868-1

9<HTUELA=hfigib> eReference

2015. (Handbook of Toxinology, Volume 1) 7 $360.00ISBN 978-94-007-5869-8

9<HTUELA=hfigji> Print + eReference

2015. 550 p. 30 illus., 15 in color. (Handbook of Toxinology, Volume 1) 7 $450.00ISBN 978-94-007-5870-4

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44

S. F. Grant, Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA (Ed)

The Genetics of ObesityIn the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), h has been more robustly observed by others. Studies from both FTO knock out and FTO overexpression mouse model sup-port the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease.

Features 7 Comprehensive review of efforts aimed at uncovering genetic variants associated with obesity 7 Covers breakthroughs in syndromic obesity, including Bardet-Biedl and Prader-Willi syndromes 7 Reviews Genome-wide Association Studies and effects on obesity research

Contents Genetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies.- Genetic Obesity Syndromes.- Genome-Wide Association Studies of Obesity.- Copy Number Variants and their Contribution to the Risk of Obesity.- Genet-ics of Childhood Obesity.- Genetic Pleiotropies of Obesity.- Functional Follow-up of Genetic Vari-ants Using FTO as the Prime Example.- Index.

Fields of interestHuman Genetics; Endocrinology; Biomedicine general



Due October 2013


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K. M. Haigis, Ph.D., Harvard Medical School, Charlestown, MA, USA (Ed)

Molecular Pathogenesis of Colorectal CancerColorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies.

Features 7 Identification and characterization of targetable oncogenic pathways in colorectal cancer 7 Dis-cussion of the current and future prospects for targeting that pathway therapeutically 7 Emerg-ing technologies for identifying new cancer related genes, and therefore new therapeutic targets

Contents Preface.- The Genetics of Colorectal Cancer.- Mo-lecular Mechanisms of Colorectal Carcinogen-esis.- The association between inflammation and colorectal cancer.- Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease.- Mutational activation of KRAS and BRAF in colorectal cancer.- The PI3K pathway in Colorectal Cancers.- TGF-ß signal-ing pathway and colorectal cancer.- The Clinical Significance of Mutations in Colorectal Can-cer.- Colorectal Cancer Genome and Its Implica-tions.- Copy-Number Alterations in the Colorectal Cancer Genome.- Genome-wide association studies in colorectal cancer.- Future prospects for leveraging molecular information in the fight against colorectal cancer.- Index.

Fields of interestCancer Research; Molecular Medicine; Protein Science



Due October 2013

2013. X, 290 p. 40 illus., 36 in color. Hardcover7 $189.00ISBN 978-1-4614-8411-0

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M. Hayat, Room 213, Library building, Union, NJ, USA (Ed)

Stem Cells and Cancer Stem Cells, Volume 11Therapeutic Applications in Disease and injury

Contents Preface. I. Embryonic stem cells.- Maintenance of human embryonic stem cell identity and Inhibi-tion of extraembryonic differentiation: Role of cnot1, cnot2 and cnot3.-Investigating the role of the embryonic stem cell self-renewal gene nanog in neoplastic processes.- Derivation and expansion of human embryonic stem cells under xeno-free, defined conditions.- Self-renewal of naïve state mouse embryonic stem cells: Role of lacdinac in lif/stat3 signaling.- Cancer gene therapy potential of neural stem cells derived from human em-bryonic stem cells and induced pluripotent stem cells. II. Cancer stem cells.- The role of cancer stem(-like) cells and epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma.- Glioma propagating cells show enhanced chemoresistance and radioresistance (an update).- Chemical genomic approaches to eradicate leukemia stem cells.- Isolation of cancer stem cells showing drug resistance in the human epithelia ovarian cancer.- Cancer stem cells in pe-diatric sarcomas.- Cancer stem cells derived from mouse induced pluripotent stem cells.- Stem-ness regulation of somatic cancer cells.- Induced differentiation of brain tumour stem cells.- Role of microenvironment in regulating stem cell and tumor initiating cancer cell behavior and its po-tential therapeutic implications.- Identification of ovarian cancer stem cells: molecular pathways. III. Hematopoietic stem cells.- Hematopoietic stem cells and bone regeneration. [...]

Fields of interestCancer Research; Oncology; Medicine/Public Health, general



Due September 2013

2013. X, 266 p. 26 illus., 18 in color. (Stem Cells and Cancer Stem Cells, Volume 11) Hardcover7 $209.00ISBN 978-94-007-7328-8

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45

M. Hayat, Kean University, Union, NJ, USA (Ed)

Tumors of the Central Nervous System, Volume 12Pineal, Pituitary, and Spinal Tumors

Contents Preface. I Molecular mechanisms.- Classification/diagnosis of brain tumors using discriminate function analysis.- Neuronal differentiation in the adult brain: cdk6 as the molecular regulator.- Pro-lactinomas: role of vegf, fgf-2 and cd31.- Human brain tumor growth: role of aquaporins.- Mo-lecular and functional characterization of human adipocytes.- II Children’s cancer.- Inhibition of neuroblastoma progression by targeting Lym-phangiogenesis: role of an endogenous soluble splice-variant of vegfr-2.- Hyperinsulinemia tends to induce growth without growth hormone in children with brain tumors after neurosur-gery.- Childhood brain tumors: proton beam therapy.- Pathogenesis of medulloblastoma: role of molecular genetic alterations.- Medulloblastomas: survival differences between children and adults.- Survivors of childhood cancer: risk of glioma and meningioma following radiotherapy.- Survivors of childhood cancer: risk of new primary neoplasms of the cns.-III Treatments.- Brain tumor typing and therapy using combined ex vivo magnetic resonance spectroscopy and molecular genomics.- Atlas-based segmentation of tumor-bearing brain images.- Nonthermal irreversible electroporation as a focal ablation treatment for brain cancer.- The role of whole brain radiation therapy for meta-static brain tumors.- Craniotomy for intracra-nial tumors: role of postoperative hematoma in surgical mortality.- Pituitary adenomas: treatment using the endonasal approach intracranial tumors: treatment with endoscopic neurosurgery.- Inci-dence of recraniotomy for postoperative infections after surgery for intracranial tumors. [...]

Fields of interestCancer Research; Oncology; Biomedicine general



Due September 2013

2014. XL, 374 p. 62 illus., 52 in color. (Tumors of the Central Nervous System, Volume 12) Hardcover7 $209.00ISBN 978-94-007-7216-8

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M. S. Islam, Karolinska Institutet Dept. Clinical Research & Education, Stockholm, Sweden (Ed)

Islets of LangerhansContents Microscopic Anatomy of the Human Islet of Langerhans.- The Comparative Anatomy of Islets.- Approaches for Imaging Islets: Recent Advances and Future Prospects.- Islet Cell Development.- High Fat Programming of β-Cell Failure.- Elec-trophysiology of Islet Cells.- ATP-Sensitive Potassium Channels in Health and Disease.- Role of Mitochondria in β-cell Function and Dys-function.- Basement Membrane in Pancreatic Islet Function.- Calcium Signaling in the Islets.- Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets.- Exocytosis in Islet β-Cells.- Proteomics and Islet Research.- Wnt Signaling in Pancreatic Islets.- Mechanisms of Pancreatic β-Cell Apoptosis in Diabetes and Its Therapies.- β-Cell Function in Obese-Hyper-glycemic Mice [ob/ob Mice].- Islet Structure and Function in the GK Rat.- The β-Cell in Human Type 2 Diabetes. [...]

Fields of interestBiomedicine general; Cell Biology; Diabetes


Product categoryHandbook

Due July 2014

Print

2nd ed. 2014. 800 p. 240 illus., 200 in color. 7 approx. $549.00ISBN 978-94-007-6685-3

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A. M. Khalil, J. Coller, Case Western Reserve University School of Medicine, Cleveland, OH, USA (Eds)

Molecular Biology of Long Non-coding RNAs Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identi-fied and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several criti-cal developments during that time.

Features 7 Brings together key experts in the field of lncRNAs 7 Has appeal for basic scientists and clinicians 7 Focuses on the recently discovered, and less understood, class of long non-coding RNAs

Contents Preface.- Chromatin regulation by long non-coding RNAs.- Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs.- Roles of long non-coding RNAs in X-chromosome inactivation.- Roles of Long Non-Coding RNAs in Genomic Imprinting.- Dysregulation of long noncoding RNAs in human disease.- Functions of long non-coding RNAs in non-mammalian systems.- Emerging technologies to study long non-coding RNAs.- Long non coding RNAs and nuclear body formation and function.- Index.

Fields of interestHuman Genetics; Biomedicine general; Protein Science



Due September 2013


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46

M. Kinter, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; C. S. Kinter, Oklahoma Medical Resarch Foundation, Oklahoma City, OK, USA

Application of Selected Reaction Monitoring to Highly Multiplexed Targeted Quantitative ProteomicsA Replacement for Western Blot Analysis

A key experiment in biomedical research is moni-toring the expression of different proteins in order to detect changes that occur in biological systems under different experimental conditions. The method that is most widely used is the Western blot analysis. While Western blot is a workhorse in laboratories studying protein expression and has several advantages, it also has a number of significant limitations.

Features 7 Explains both the theoretical and experimental details of the selected reaction monitoring experi-ment as it is applied to proteins 7 Describes a new type of quantitative proteomics experiment called selected reaction monitoring 7 Reviews the experiment result of a robust and powerful method to measure the abundance of a protein in complex samples

Contents The use of mass spectrometry for highly selective detection.- overview of how the selected reaction monitoring experiment works.- Designing a selected reaction monitoring method for a pro-tein.- Example analyses include: sample process-ing, sample analysis, data processing.- Future Directions.

Fields of interestBiomedicine general; Proteomics; Mass Spectrom-etry


Product categoryBrief

Due October 2013

2013. V, 55 p. 13 illus., 9 in color. (SpringerBriefs in Systems Biology) Softcover7 approx. $49.95ISBN 978-1-4614-8665-7

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S. Klimpel, Goethe-University, Frankfurt, Germany; H. Mehlhorn, Heinrich Heine University, Düsseldorf, Germany (Eds)

Bats (Chiroptera) as Vectors of Diseases and ParasitesFacts and Myths

This book gathers contributions by 16 internation-al authors on the phenomenon “bats,” shedding some light on their morphology, the feeding be-haviors (insects, fruits, blood) of different groups, their potential and confirmed transmissions of agents of diseases, their endo- and ectoparasites, as well as countless myths surrounding their lifestyle (e.g. vampirism, chupacabras, batman etc.). Bats have been known in different cultures for several thousand centuries, however their nocturnal activities have made them mysterious and led to many legends and myths, while proven facts remained scarce. Even today, our knowledge of bats remains limited compared to other groups in the animal kingdom.

Features 7 Covers the morphology and biology of bats and the potential vectorship of agents of diseases and parasites 7 Special attention is given at the numerous myths that had been told or are still told on these unique organisms 7 Presents some of the most interesting and most important findings in bat research

Contents The World of Bats.- The Astonishing Morphol-ogy of Bats.- Bats as Potential Reservoir Hosts for Vector-Borne Diseases.- Bat Endoparasites.- Macroparasites – Ectoparasites.- Glimpses into how Bats Fly.- Blood-Licking Bats.- Vampirism in Medicine and Culture.- Chupacabras and “Goat Milkers”.- Myths on Candiru.

Fields of interestParasitology; Medical Microbiology; Health Pro-motion and Disease Prevention



Due September 2013

2013. X, 175 p. 38 illus., 36 in color. (Parasitology Research Monographs, Volume 5) Hardcover7 $189.00ISBN 978-3-642-39332-7

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M. Klink, Institute of Medical Biology Polish Academy of Sciences, Lodz, Poland (Ed)

Interaction of Immune and Cancer CellsThe tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, en-dothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells.

Features 7 Comprehensively describes the role of all im-portant immune cell types in cancer 7 Depicts in a structured way immune cell function in the tumor environment, progression and treat-ment 7 Intelligibly delineates therapeutic vac-cines and immunotherapies against cancer

Contents Immune cells within tumor microenvironment.- Tumor-stroma interaction and cancer progres-sion.- The role of tumor associated macrophages (TAMs) in tumor progression.- Dendritic cells dysfunction and tumor progression.- Myeloid-derived suppressor cells (MDSC) and tumor growth.- Tumor-infiltrating lymphocytes and their role in solid tumor progression.- Polymorpho-nuclear neutrophils and tumor: friend or foe?.- Cancer immunosurveillance and immunoedit-ing.- Adoptive T cell immunotherapy – Perfecting self-defense.- Monoclonal antibodies to CTLA4 with focus on ipilimumab.

Fields of interestImmunology; Cancer Research; Vaccine



Due October 2013


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47

L. Konieczny, I. Roterman-Konieczna, P. Spólnik, Jagiellonian University Medical College, Krakow, Poland

Systems BiologyFunctional Strategies of Living Organisms

Contents The Structure and Function of Living Organ-isms.- General physiochemical properties of biological structures.- Self-organization.- Hypoth-esis - Protein folding simulation hypothesis - late stage intermediate – role of water.- Energy in Biology – Demand and Use.- General principles of thermodynamics.- Biological energy sources – synthesis of water.- ATP synthesis.- Photo-synthesis.- Direct and indirect exploitation of energy sources.- Energy conversion efficiency in biological processes.- Entropic effects.- Energy requirements of organisms.- Information – Its Role and Meaning in Organisms.- Information as a quantitative concept. - Reliability of information sources.- Types of information conveyed by DNA. - Information entropy and mechanisms assisting selection.- The role of information in interpreting pathological events.- Hypothesis - Protein folding early stage intermediate.- Regulation in Biological Systems.- The cell and the organism.- The prin-ciple and mechanism of automatic intracellular regulation.- Regulatory coupling between cells and organisms – hierarchical properties of regulation.- Regulatory mechanisms on the organism level.- Basic principles of regulation in biology.- Regula-tion levels.- Hypothesis - Proteome construction hypothesis.- Interrelationships in Organized Biological Systems.- The need of mutual relations in biological systems.- Cooperation and coordina-tion.- The characteristics of process coordination in individual cells and organisms.- Mutual rela-tionship between cells and the organism – activa-tion and inhibition of enzymes (rapid effects). [...]

Fields of interestBiomedicine general; Systems Biology; Cell Biol-ogy



Due November 2013

2014. 275 p. 157 illus., 91 in color. Hardcover7 approx. $189.00ISBN 978-3-319-01335-0

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X. Li, University of Ulster, Londonderry, UK

Functional Magnetic Resonance Imaging ProcessingContents Preface.- MRI perfusion weighted imaging analy-sis. - Perfusion imaging. - Gamma-variate fitting. - AIF selection. - Dispersion effects in DSC-MRI. - Summary of the PWI algorithm.- First level fMRI data analysis for activation detection. - fMRI experimental design. - fMRI data pre-processing. - Activation detection: model free and model based methods. - Models for hemodynamic re-sponse function and drift. - General linear model (GLM) for activation detect. - Hypothesis test and threshold correction. - Summary of algorithm for 1st level fMRI data analysis.- 2nd level fMRI data analysis using mixed model. - Mixed model for fMRI data analysis. - Numerical analysis for mixed effect models. - Iterative trust region method for ML estimation. - Exception trust region algorithm for second level fMRI data analysis. - Degree of freedom (DF) estimation. - fMRI data analysis future directions. - Second level fMRI data pro-cessing algorithm summary.- fMRI effective con-nectivity study. - Nonlinear system identification method for fMRI effective connectivity analysis. - Model selections for effective connectivity study. - Robust method for second level analysis. - Ef-fective connectivity for resting-state fMRI data. - Limitations for fMRI effective connectivity in this study. - Summary of the algorithm for fMRI effec-tive connectivity study.-Diffusion weighted imag-ing analysis. - Basic principle of diffusion MRI and DTI data analysis. - Fiber tracking. - High angular resolution diffusion imaging (HARDI) analysis. - Adaptive Q-ball imaging regularization. - Diffu-sion spectrum imaging. [...]

Fields of interestNeurosciences; Computer Imaging, Vision, Pat-tern Recognition and Graphics; Statistics and Computing/Statistics Programs



Due September 2013


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D. A. Liebermann, B. Hoffman, Temple University School of Medicine, Philadelphia, PA, USA (Eds)

Gadd45 Stress Sensor GenesEmerging evidence indicates that the Gadd45 fam-ily of genes play a unique and critical role as sen-sors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other research-ers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli.

Features 7 Provides a comprehensive picture of the unique global role Gadd45 genes play as stress sen-sors and the molecular pathways involved 7 The functions of Gadd45 proteins are mediated by protein-protein interactions that modulate struc-ture/function of other cellular proteins implicated in cell cycle regulation 7 Gadd45 proteins are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress

Contents Gadd45 in stress signaling, cell cycle control and apoptosis.- Gadd45 in Modulation of Solid Tumors and Leukemia.- Gadd45 Proteins: Key players of repair-mediated DNA demethylation.- Gadd45 proteins in Immunity.- Gadd45 in the liver — Signal transduction and transcriptional mechanisms.- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelop-ment, Neuronal Injury, and Cognitive Neuroepi-genetics.- Gadd45 stress sensors in preeclampsia.- Index.

Fields of interestGene Function; Biochemistry, general; Human Genetics



Due September 2013

2013. XIV, 140 p. 18 illus., 11 in color. (Advances in Experimental Medicine and Biology, Volume 793) Hardcover7 $139.00ISBN 978-1-4614-8288-8

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48

S. Magez, Vrije Universiteit Brussel Faculty of Science, Brussels, Belgium; M. Radwanska, Brussels, Belgium (Eds)

Trypanosomes and TrypanosomiasisThis new volume written by experts in the field of trypanosome research covers every aspect of trypanosome-vector-host biology. It is a must read for basic researchers working with trypanosomes and related organisms, infection and drug devel-opment as well as parasitology in a broader sense.

Features 7 Covers all aspects of Trypanosoma infec-tion 7 Connects basic science with clinical research and drug design 7 Provides in depth information on trypanosome-vector-host biology

Contents Tsetse fly biology: where it all starts.- Trypanolytic activity of NHS: a first defense.- Antigenic varia-tion: the answer to host immunity.- Early onset of host immunity: the big unknown.- Myeloid cells: parasite control versus pathology.- Adaptive immunity - T cells: old and new views on defense part I.- Adaptive immunity - B cells: old and new views on defense part II.- Proteomics of trypano-somes: what’s in there.- Diagnosis: when to treat and when not.- Drug design: the past, the pres-ent and future.- Nanobody technology: a novel approach to an old fight.- Sodalis as expression system: using the Trojan horse.- Nagana: it’s not all about HAT.

Fields of interestParasitology; Medical Microbiology; Infectious Diseases



Due September 2013


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H. Mehlhorn, Heinrich Heine University Department of Zoomorphology, Düsseldorf, Germany; Z. Wu, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China, People’s Republic; B. Ye, Chongqing Medical University Pathogenic Biology, Chongqing, China, People’s Republic (Eds)

Treatment of Human Parasitosis in Traditional Chinese MedicineContents Introduction ( Heinz Mehlhorn) .- Schistoso-miasis in China ( Wei Hu) .- Clonorchis and Opisthorchis infection and their impact on cancer ( Banchob Sripa) .- Angiostrongylus cantonensis in China (Wu Zhongdao, Lv Zhiyue) .- Traditonal Chinese treatment methods against schistosomes and other trematodes ( Wu Zhongdao, Su Xi) .- Treatment methods of Traditional Chinese Medicine for hydatidosis and other tapeworm infections ( Ye Bin) .- Traditonal Chinese treat-ment methods against nematodes ( Wu Zhongdao, Su Xi) .- Toxoplasmosis and traditional chinese medicine (Lv Fangli) .- Malaria in China (Ying Wang) .- Malaria and traditional Chinese medi-cine (Xu Wenyue) .- Intestinal protozoan diseases and traditional Chinese medicine (Ma Changling) .- Dengue fever and similar vector borne diseases in China (Wu Yu) .- Tsutsugamushi in China (Zheng Xiaoying) .- Leishmaniasis in China (Chen Jianping) .- Impact of climate and globalization on parasites (Heinz Mehlhorn) .- Conclusions (Heinz Mehlhorn).

Fields of interestParasitology; Medicine/Public Health, general; Complementary & Alternative Medicine



Due September 2013

2013. IV, 263 p. 138 illus., 116 in color. (Parasitology Research Monographs, Volume 6) Hardcover7 $189.00ISBN 978-3-642-39823-0

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A. E. Nixon, Dyax Corporation Discovery Research, Cambridge, MA, USA (Ed)

Therapeutic PeptidesMethods and Protocols

Features 7 Features methods for the identification of pep-tide therapeutic candidates through a wide variety of techniques 7 Includes step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents Design of Phage-Displayed Cystine-Stabilized Mini-Protein Libraries for Proteinaceous Binder Engineering.- Construction of a Filamentous Phage Display Peptide Library.- Engineering Bio-Active Peptide-Based Therapeutic Molecules.- T7 Lytic Phage-Displayed Peptide Libraries: Construction and Diversity Characterization.- Af-finity Selection Using Filamentous Phage Display.- Bioprospecting Open Reading Frames for Peptide Effectors.- Identification of Ideal Peptides for Heterovalent Ligands.- Substrate Phage Display for Protease Substrate Sequence Characterization: Bovine Factor Xa as a Model System.- Engineer-ing Peptide Therapeutics Using MIMETIBODY™ Technology.- Evaluation of Peptides as Protease Inhibitors and Stimulators.- Assessment of Anti-microbial (Host Defense) Peptides as Anti-Cancer Agents.- Peptide Labelling Strategies for Imaging Agents.- Peptide Optimization and Conjugation Strategies in the Development of Molecularly Targeted Magnetic Resonance Imaging Contrast Agents.- Evaluation of Prenylated Peptides for Use in Cellular Imaging and Biochemical Analysis.- Ultraviolet Absorption Spectroscopy of Peptides.- Fluorescence Spectroscopy of Peptides.- Circular Dichroism of Peptides.- Fourier Transform Infrared Spectroscopy of Peptides.

Field of interestPharmacology/Toxicology



Due December 2013

2014. Approx. 265 p. 58 illus., 5 in color. (Methods in Molecular Biology, Volume 1088) Hardcover7 approx. $119.00ISBN 978-1-62703-672-6

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49

M. A. Repka, University of Mississippi School of Phar National Center for Natural Products Res, University, MS, USA; N. Langley, BASF Corporation, Tarrytown, NY, USA; J. DiNunzio, Bridgewater, NJ, USA (Eds)

Melt ExtrusionMaterials, Technology and Drug Product Design

Contents Melt Extrusion in Drug Delivery: Three Decades of Progress.- Twin Screw Extrusion for Pharma-ceutical Processes.- Properties and Applications of Polyvinyllactam Polymers.- Properties and Applications of Hypromellose Acetate Succinate (HPMCAS) for Solubility Enhancement Using Melt Extrusion.- Cellulose Ethers for Extrusion Applications.- Properties and Applications of Polyethylene Oxide and Ethylcellulose for Tamper Resistance and Controlled Drug Delivery.- For-mulation Development of Amorphous Solid Dispersions Prepared by Melt Extrusion.- Non-Sink In Vitro Dissolution Testing of Amorphous Solid Dispersions.- Manufacture of Pharmaceuti-cally Relevant Materials by Mechanochemistry Using Twin Screw Extrusion.- Melt Extruded Controlled Release Dosage Forms.- Excipient/API Melt Processing via Injection Molding.- Devices and Implants Prepared Using Hot Melt Extrusion.- Solid Lipid Extrusion.- Formulation, Bioavail-ability and Manufacturing Process Enhancement: Novel Applications of Melt Extrusion in Enabling Product Development.- Hot Melt Extrusion as a Continuous Pharmaceutical Manufacturing Process.- Hot-Melt Extrusion Process Design Us-ing Process Analytical Technology.- Consistency of Pharmaceutical Products: An FDA Perspective on Hot-melt Extrusion Process.- Melt Extrusion: A Commercial Perception to Practicality.- Future Trends.

Fields of interestBiomedicine general; Pharmaceutical Sciences/Technology



Due September 2013

2013. I, 563 p. 261 illus., 141 in color. (AAPS Advances in the Pharmaceutical Sciences Series, Volume 9) Hardcover7 $209.00ISBN 978-1-4614-8431-8

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A. Santos, Instituto de Microbiologia Paulo de Góes, Rio de Janeiro, Brazil; M. Branquinha, Ins. de Microbiologia Paulo de Góes, Rio de Janeiro, Brazil; C. d’Avila-Levy, L. Kneipp, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; C. Sodré, Ins. de Microbiologia Paulo de Góes, Rio de Janeiro, Brazil (Eds)

Proteins and Proteomics of Leishmania and TrypanosomaContents Preface.- Biology of Human Pathogenic Try-panosomatids: Epidemiology, Lifecycle and Ultrastructure.- Selection of Molecular Targets for Drug Development against Trypanosomatids.- A2 and other visceralizing proteins of Leishmania: role in pathogenesis and application for vaccine development.- Arginase in Leishmania.- The heat shock proteins of Trypanosoma cruzi.- The Gp82 Surface Molecule of Trypanosoma cruzi Meta-cyclic Forms.- The Gp85 Surface Glycoproteins from Trypanosoma cruzi.- Trypanosoma cruzi Trans-Sialidase: Structural Features and Biologi-cal Implications.- Surface Topology Evolution of Trypanosoma Trans-Sialidase.- Ecto-Nucleotid-ases and Ecto-Phosphatases from Leishmania and Trypanosoma Parasites.- Gp63 Function in the Interaction of Trypanosomatids with the Inverte-brate Host – Facts and Prospects.- Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis.- The Expected Outcome of the Trypanosoma cruzi Proteomic Map: a Review of its Potential Biologi-cal Applications for Drug Target Discovery.- Pro-teomics advances in the study of Leishmania parasites and leishmaniasis.- Towards the Phos-phoproteome of Trypanosomatids. Index.

Fields of interestParasitology; Microbial Genetics and Genomics; Infectious Diseases



Due September 2013

2013. V, 399 p. 54 illus., 37 in color. (Subcellular Biochemistry, Volume 74) Hardcover7 $209.00ISBN 978-94-007-7304-2

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E. Spangenburg, University of Maryland School of Public Health, College Park, MD, USA (Ed)

Integrative Biology of Women’s HealthDefining and understanding cellular and mo-lecular mechanisms that are relevant to women’s health has become a critical area of scientific pur-suit. Until recently, very little effort has been place on defining or understanding critical differences between women and men that may be critical to the overall health of the woman.

Features 7 Integrates the work of young, upcoming investigators with that of established investi-gators to encourage innovative thoughts and ideas 7 Focuses on three areas: skeletal-muscle function, metabolic function, and cardiovascular function 7 Provide “translational” chapters that attempt to place the basic science work in context within our current understanding of the human

Contents 1. Influence of ovarian hormones on skeletal muscle contractility.- 2. Novel Findings in Bone biology: impact on bone health for women.- 3. Estrogen Effects on Skeletal Muscle.- 4. The contribution of ovarian hormones to the cellular regulation of lipid metabolism.- 5. The role of estrogens in the regulation of peripheral glucose dynamics.- 6. The Impact of Estrogen Receptor a Expression in the Pathogenesis of Metabolic Syndrome- 7. Metabolic Health in the Aging Fe-male: Human Perspective.- 8. Transitions Across a Lifetime: Unique Cardiovascular Physiology of Women and Relationship to Cardiovascular Disease Risk.- 9. Estrogen, Cardiac Protection and Aging.- 10. Diet and Exercise Are Potent Modula-tors of Cardiovascular Disease in Women.

Fields of interestHuman Physiology; Cell Biology; Endocrinology



Due September 2013

2013. Approx. 300 p. Hardcover7 $189.00ISBN 978-1-4614-8629-9

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50

S. G. Sprecher, University of Fribourg, Switzerland (Ed)

Brain DevelopmentMethods and Protocols

Contents Immunostaining of the Developing Embryonic and Larval Drosophila Brain.- Non-Fluorescent RNA In Situ-Hybridization Combined with An-tibody Staining to Visualize Multiple Gene Expres-sion Patterns in the Embryonic Brain of Drosophi-la.- Analysis of Complete Neuroblast Cell Lineages in the Drosophila Embryonic Brain via DiI-Label-ing.- Flybow to Dissect Circuit Assembly in the Drosophila Brain.- Immunofluorescent Labeling of Neural Stem Cells in the Drosophila Optic Lobe.- Using MARCM to Study Drosophila Brain Development.- Dye Coupling and Immunostain-ing of Astrocyte-Like Glia Following Intracellular Injection of Fluorochromes in Brain Slices of the Grasshopper, Schistocerca gregaria.- Methods in Brain Development of Molluscs.- In Situ Hybrid-ization and Immunostaining of Xenopus Brain.- Microinjection Manipulations in the Elucidation of Xenopus Brain Development.- Morpholino Studies in Xenopus Brain Development.- Sensitive Whole-Mount Fluorescent In Situ Hybridization in Zebrafish Using Enhanced Tyramide Signal Amplification.- Dynamic Neuroanatomy at Sub-cellular Resolution in the Zebrafish.- Anatomical Dissection of Zebrafish Brain Development.- Im-munohistochemistry and In Situ Hybridization in the Developing Chicken Brain.- Transplantation of Neural Tissue: Quail-Chick Chimeras.- RNAi-Based Gene Silencing in Chicken Brain Develop-ment.- Immunohistochemistry and RNA In Situ Hybridization in Mouse Brain Development.- In Utero Electroporation to Study Mouse Brain Development.- The Cre/Lox System to Assess the Development of the Mouse Brain.

Fields of interestNeurosciences; Neurobiology



Due September 2013

2013. X, 330 p. 63 illus., 49 in color. (Methods in Molecular Biology, Volume 1082) Hardcover7 $139.00ISBN 978-1-62703-654-2

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A. Suzumura, Nagoya University, Nagoya, Japan; K. Ikenaka, National Inst of Physiological Science, Aichi, Japan (Eds)

Neuron-Glia Interaction in NeuroinflammationAccumulation on glia is an active pathological element in many neurological disorders. Gliosis produces neuroinflammation through both neu-rotrophic and inflammatory means, but the exact mechanism through which this happens remain unclear. It is suspected that damage to neurons activates the growth of glial cells. The proposed book focuses on the interaction between neurons and glia to help elucidate the pathophysiology of neuroinflammation in neurological disorders.

Features 7 Focuses on neuron-glia interaction of vari-ous aspects for understanding of neurological disorders 7 Discusses interactions between neurons and microglia during neuroinflamma-tion 7 Written by experts in the field

Contents Acute, Chronic, and Non-classical Neuroinflam-mation: Definitions in a Changing Scientific Environment.- Neuroinflammation in Neurologi-cal Disorders.- Factors from Intact and Damaged Neurons.- Interactions between Neurons and Microglia During Neuroinflammation.- Neuron-Astrocyte Interactions in Neuroinflamma-tion.- Neuron-oligodendrocyte Interactions in Neuroinflammation.- Neuron-glia Interaction via Neurotrophins.- Glial Communication via Gap Junction in Neuroinflammation.- Toll-Like Recep-tors and Neuroinflammation.- The Blood-Brain-Barrier in Neuroinflammation.

Fields of interestNeurosciences; Neurology



Due September 2013

2013. X, 300 p. 25 illus., 24 in color. (Advances in Neurobiology, Volume 7) Hardcover7 $189.00ISBN 978-1-4614-8312-0

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The MycotaA Comprehensive Treatise on Fungi as Experimental Systems for Basic and Applied Research

Series editor: K. Esser

Volume 12

O. Kurzai, Friedrich Schiller University of Jena, Jena, Germany (Ed)

Human Fungal PathogensWhereas plant and insect infections are com-monly caused by fungi, only a small minority of the vast diversity of fungal species is pathogenic to humans. Despite this, fungal infections cause considerable morbidity and mortality worldwide.

Features 7 A completely revised new edition 7 Written by experts 7 Richly illustrated

Contents From Commensal to Pathogen: Candida albicans.- Aspergillus fumigatus: Saprophyte to Pathogen.- Systems Biology Approaches to Understand and Predict Fungal Virulence.- Receptor-Ligand Interactions in Fungal Infections.- Macrophages in the Immune Response against Cryptococcus.- T Cell Responses in Fungal Infections.- Molecular Mechanisms of Histoplasma Pathogenesis.- Visu-alizing Immune Responses in Fungal Infections – Established and Novel Methods.- Mucosal Im-munology in Candida albicans Infection.- Invasive Aspergillosis in the Intensive Care Unit.- Molecu-lar Epidemiology of Pneumocystis Outbreaks.- Infections Caused by Mucorales.- Diagnostics of Fungal Infections.- Therapeutic Strategies in Fungal Infections.- Antifungal Pharmacokinetics.

Fields of interestMedical Microbiology; Immunology; Allergology


Product categoryHandbook

Due October 2013

2nd ed. 2013. X, 415 p. 55 illus., 34 in color. Hardcover7 approx. $269.00

Subscription price, valid for subscribers of the whole series7 approx. $239.00ISBN 978-3-642-39431-7

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51

I. Wakabayashi, Hyogo College of Medicine, Hyogo, Japan; K. Groschner, Medical University of Graz Center for Physiological Medicine, Graz, Austria (Eds)

Interdisciplinary Concepts in Cardiovascular HealthThis book provides an introduction to the prin-ciples of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. Further, it promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiol-ogy. The book offers a valuable resource work for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.

Features 7 Provides comprehensive and well-orga-nized overview of a highly interdisciplinary field 7 Covers a wide range of biomedical re-search areas 7 Clearly arranged to create an easy to use knowledge base

Fields of interestMolecular Medicine; Metabolic Diseases; Health Promotion and Disease Prevention



Due August 2013

2013. Approx. 650 p. 82 illus., 50 in color. (3-volume-set)7 $459.00ISBN 978-3-319-01416-6

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C. Waldsich, University of Vienna, Austria (Ed)

RNA FoldingMethods and Protocols

Contents Predicting RNA Structure: Advances and Limita-tions.- Cis-Acting 5’ Hammerhead Optimization for In Vitro Transcription of Highly Structured RNAs.- RNA Structural Analysis by Enzymatic Digestion.- A Mutate-and-Map Protocol for Inferring Base Pairs in Structured RNA.- Map-ping RNA Structure In Vitro Using Nucleobase-Specific Probes.- Massively Parallel RNA Chemical Mapping with a Reduced Bias MAP-Seq Proto-col.- Probing RNA Folding by Hydroxyl Radical Footprinting.- Monitoring Global Structural Changes and Specific Metal Binding Sites in RNA by In-Line Probing and Tb(III) Cleavage.- Chemi-cal Probing of RNA in Living Cells.- A Chemo-genetic Approach to Study the Structural Basis of Protein-Facilitated RNA Folding.- Applying UV Crosslinking to Study RNA-Protein Interac-tions in Multicomponent Ribonucleoprotein Complexes.- The Kinetics of Ribozyme Cleavage: A Tool to Analyze RNA Folding as a Function of Catalysis.- RNA Catalytic Activity as a Probe of Chaperone-Mediated RNA Folding.- Evalua-tion of RNA Chaperone Activity In Vivo and In Vitro Using Misfolded Group I Ribozymes.- RNA Conformational Changes Analyzed by Compara-tive Gel Electrophoresis.- Detecting RNA Tertiary Folding by Sedimentation Velocity Analytical Ultracentrifugation.- RNA Folding Dynamics Using Laser Assisted Single-Molecule Refolding.- RNA Refolding Studied by Light-Coupled NMR Spectroscopy.- Exploring RNA Oligomerization and Ligand Binding by Fluorescence Correlation Spectroscopy and Small Angle X-Ray Scattering.

Fields of interestHuman Genetics; Nucleic Acid Chemistry



Due October 2013

2014. 340 p. 61 illus., 36 in color. (Methods in Molecular Biology, Volume 1086) Hardcover7 $139.00ISBN 978-1-62703-666-5

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J. L. Workman, S. M. Abmayr, Stowers Institute for Medical Research, Kansas City, MO, USA (Eds)

Fundamentals of Chromatin While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamen-tals of chromatin. Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes.

Features 7 Focuses on fundamental properties of chromatin that include structure, composition, modifications and functions in nuclear processes such as transcription, and DNA replication and repair 7 Chapters from this book have been written by leading researchers in the field 7 This book provides an updated overview of the basics to knowing the function of chromatin

Contents Preface.- Histone, Nucleosome and Chromatin Structure.- Histone Chaperones in the Assem-bly and Disassembly of Chromatin.- Chromatin Remodeling Complexes.- Regulating Chromatin by Histone Acetylation.- Histone Methylation in Chromatin Signaling.- Histone Ubiquitylation Control of Gene Expression.- Regulation of Chromatin Structure and Function by PARP-1 and ADP-ribosylation.- Histone phosphoryla-tion and chromatin dynamics.- Reading histone modifications.- Properties and functions of histone variants.- Transcription through Chroma-tin.- Chromatin remodeling in DNA repair and replication.- Heterochromatin: A Critical Part of the Genome.- Emerging Areas of Chromatin Research.- Index.

Fields of interestHuman Genetics; Biomedicine general; Gene Expression



Due November 2013


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52

Z. Yang, National University of Singapore, Singapore, Singapore (Ed)

Neural Computation, Neural Devices, and Neural ProsthesisFeatures 7 Assembles a base of knowledge from different fields of neuroscience, computation, material and technology, circuits and system, clinical reports, and psychology 7 Provides a systematic ap-proach guiding future educational and research activities 7 Explores an interdisciplinary area still in its infancy, but with the potential to create significant impact

Contents 1. Electromagnetic Effects of Wireless Transmis-sion for Neural Implants.- 2. Energy-Efficient Digital Processing for Neural Action Potentials.- 3. Doppler Radar Noncontact Vital Sign Monitor-ing.- 4. From Auditory and Visual to Immersive Neurofeedback Application to Diagnosis of Alzheimer’s Disease.- 5. Eyelid Reanimation Pro-totype for Facial Nerve Paralysis.- 6. Flexible Elec-trode for Implantable Neuroprosthetic Devices.- 7. Visual Prostheses.- 8. Near-Field Wireless Power and Data Transmission to Implantable Neuropros-thetic Devices.- 9. Neural Recording and Neural Stimulation Circuits and Systems.- 10. Neuron Chips.- 11. Analysis and Design of 3D Potentiostat for Deep Brain Implantable Devices.- 12. Compu-tational Models and Hardware Implementations for Neuron-Machine Interactions.- 13. Analysis and Design of 3D Potentiostat for Deep Brain Implantable Devices.- 14. Advances in Learning Visual Saliency: From Image Primitives to Seman-tic Contents.

Fields of interestBiomedicine general; Biomedical Engineering

Target groupsGraduate


Due November 2013


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T. Zhu, Syngenta Biotechnology, Inc. (SBI), Research Triangle Park, NC, USA (Ed)

Genome Profiling for Genetic Marker DiscoveryRecent advancement in genome technology, especially high throughput low cost sequenc-ing and microarrays, revolutionizes the way for discovering genetic markers and enables their new applications. This volume is designed to build a genetic tool box with these emerging techniques for molecular biologists, geneticists, clinical scientists and breeders. While theses methods and protocols were developed in genomics and bioin-formatics laboratories in the forefront of the fields, the format of each method or protocol is easy to understand and practical to address different chal-lenging issues in genetic marker discovery.

Fields of interestHuman Genetics; Bioinformatics; Molecular Medicine



Due December 2013

2012. 300 p. (Methods in Molecular Biology, Tentative volume 2258) Hardcover7 approx. $99.50ISBN 978-1-60327-350-3

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