stem cell concepts renew cancer research by john e. dick blood volume 112(13):4793-4807 december 15,...

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Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology

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Page 1: Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology

Stem cell concepts renew cancer research

by John E. Dick

BloodVolume 112(13):4793-4807

December 15, 2008

©2008 by American Society of Hematology

Page 2: Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology

John E. Dick.

John E. Dick Blood 2008;112:4793-4807

©2008 by American Society of Hematology

Page 3: Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology

Labeling pattern of leukemic cells in marrow of patient 1.

John E. Dick Blood 2008;112:4793-4807

©2008 by American Society of Hematology

Page 4: Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology

Models of tumor heterogeneity.

John E. Dick Blood 2008;112:4793-4807

©2008 by American Society of Hematology

Page 5: Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology

Hierarchy of leukemia stem cells in AML. Like the normal hematopoietic system, AML is organized as a hierarchy of distinct cell classes that is sustained by a subset of leukemia stem

cells (or SCID-leukemia initiating cells [SL-ICs], as assayed in immunodef...

John E. Dick Blood 2008;112:4793-4807

©2008 by American Society of Hematology

Page 6: Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology

Models of tumor initiation and progression.

John E. Dick Blood 2008;112:4793-4807

©2008 by American Society of Hematology