statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. - pubmed - ncbi
DESCRIPTION
StatinsTRANSCRIPT
-
KEYWORDS:
PubMed Commons home
How to join PubMed Commons
Expert Rev Clin Pharmacol. 2015 Mar;8(2):189-99. doi: 10.1586/17512433.2015.1011125. Epub 2015 Feb 6.
Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms.Okuyama H , Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T, Uchino H.
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present aperspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins thatimpair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and 'heme A', andthereby ATP generation. Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, whichin turn protects arteries from calcification. Statins inhibit the biosynthesis of selenium containing proteins, one of whichis glutathione peroxidase serving to suppress peroxidative stress. An impairment of selenoprotein biosynthesis may bea factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency. Thus,the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated bythe pervasive use of statin drugs. We propose that current statin treatment guidelines be critically reevaluated.
ATP generation; atherosclerosis; coenzyme Q10; heart failure; mitochondrial toxin; selenoprotein; statin; statincardiomyopathy; vitamin K2
PMID: 25655639 [PubMed - in process]
PubMed Commons
0 comments
Abstract
1
Author information
LinkOut - more resources
Full text links
PubMed
Statins stimulate atherosclerosis and heart failure: pharmacologic... http://www.ncbi.nlm.nih.gov/pubmed/25655639
1 of 1 5/5/15, 23:59