spontaneous damage to dna. examples of dna damage induced by radiation and chemicals

Spontaneous Damage to DNA

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Spontaneous Damage to DNA

Examples of DNA Damage Induced by Radiation and Chemicals

Direct Repair of Thymine Dimers

Not in humans

Page 6: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals

A metiltransferase é gasta nesta reacção

Page 7: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals

Base-Excision Repair

Page 8: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals

Nucleotide-Excision Repair of Thymine Dimers

Page 9: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals

Xeroderma pigmentosum

•Autosomal recessive mutations in several complementation groups

•Extreme sensitivity to sunlight

•Predisposition to skin cancer (mean age of skin cancer = 8 yrs vs. 60 for normal population)

Page 10: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals

Nucleotide excision repair - Energéticamente ineficiente

Page 11: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals

Mismatch Repair in E. coli

Page 12: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals

Page 13: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals

Teste de Ames para agentes mutagenicos

MUTAGENESIS DNA DAMAGE DNA REPAIR RECOMBINATION

DNA Repair 1 : Types of DNA damage

DNA damage & repair

DNA Damage. DNA damage DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000

DNA Repair. Spontaneous Alterations Depurination and Deammination

Cellular response to DNA damage

DNA Damage and DNA Repair - University of North Carolina ... · Possible Consequences of DNA Damage DNA Damage Via UV, oxidation or methylation damage Mutation Cell Death Nothing

Arginine Supplementation and DNA Damage

Engineered Nanoparticles Induce DNA Damage in …vetmed.tamu.edu/media/908279/romoser nano life 2014 nano dna damage...Engineered Nanoparticles Induce DNA Damage in Primary Human Skin

Autophagy-Dependent Regulation of the DNA Damage …DNA Damage and Cellular Stress Responses Autophagy-Dependent Regulation of the DNA Damage Response Protein Ribonucleotide Reductase

Satellite RNA Increases DNA Damage and Accelerates Tumor Formation … · DNA Damage and Repair Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models

DNA Damage, DNA Technologies, Genetics Since Gregor Mendel

DNA Repair, Recombination Genome Instability · DNA Repair, Recombination Genome Instability Lichun Jiang, ... Source of DNA damage ... Consequence of DNA Damage DNA repair Cell cycle

DNA damage and DNA repair · DNA damage and DNA repair Spontaneous loss of bases Alkylation of bases Oxidation of bases UV-light induced damage: Cyclobutane dimers …

DNA damage tolerance pathway involving DNA polymerase ι and

Transcriptomics, DNA Damage and DNA Damage … · Transcriptomics, DNA Damage and DNA Damage Response in Space Honglu Wu NASA Johnson Space Center Houston, Texas, USA 2018-04-26T11:56:16+00:00Z

Mapping the DNA Damage Response

CO6-1 Characterization of Clustered DNA Damage Induced by ......tered DNA damage is a unique radiation damage [1], and estimate quantity and quality of clustered DNA damage induced

Dna damage and repair

DNA Damage Repair Mechanisms

DNA Repair 1 : Types of DNA damage Radiobiology 2012

DNA Damage, DNA Repair, Aging, and Neurodegenerationperspectivesinmedicine.cshlp.org/content/5/10/a025130.full.pdf · DNA DAMAGE AND DNA REPAIR PATHWAYS Nucleic acids, proteins, and

the DNA Damage Response

12.6 DNA Repair. DNA Repair Errors in DNA replication or damage to DNA create mutations Errors in DNA replication or damage to DNA create mutations -

Spermatogenesis, DNA damage and DNA repair mechanisms in

DNA damage and repair lecture - unc.edu · DNA damage and repair ... Fanconi’s anemia - DNA repair. BRCA2 and 5 other genes ... Microsoft PowerPoint - DNA damage and repair lecture.ppt

Chromatin Responses to DNA Damage · * DNA repair * Checkpoint regulation * DNA replication Chromatin responses to DNA damage. Sensing DNA damage. Repairing DNA damage…

DNA base damage and repair (9-17) - University of Floridaoge.med.ufl.edu/courses/gms 6001/DNA base damage... · Commonly, DNA repair (and damage response mechanisms) are targeted

Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

Dna damage

Differences in DNA damage and repair in human …candle.am/wp-content/uploads/2017/12/NellyBabayan.pdfEvery cell experiences up to 10 5 spontaneous or induced DNA lesions per day Research

Dna Damage Nd Repair

DNA Damage - Columbus Labs · DNA Damage Figure 5-46. A summary of spontaneous alterations likely to require DNA repair. The sites on each nucleotide that are known to be modified

Dna damage checkpoints

DNA Damage for Students