spectroscopic methods-introduction & acknowledgement

8/11/2019 Spectroscopic Methods-Introduction & Acknowledgement

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Acknowledgement

We would like to thank the Calvin Mckain Library for providing us with worthwhile information

aiding in the completion of our project. We would also like to thank Skoog 8th/9thedition the

book has been a very useful source throughout our research. We would like to thank various

certified internet sources for providing us with necessary information. We also express our

gratitude to Mrs.Gordon-Smith and Mr. OBrien for giving us this project to do and guiding us

throughout the entire process

Introduction

The advancement of Spectroscopic methods is very important to the Pharmaceutical Industry. A

wide variety of spectroscopic methods have been employed in the Pharmaceutical Industry for

drug analysis for example ultra violet and visible spectroscopy which incorporates the principle

that drug molecules absorb radiation in the ultraviolet region of the spectrum as well as the

visible region. Infrared spectroscopy uses electromagnetic radiation. Nuclear Magnetic

Resonance Spectroscopy commonly known as NMR has become the one of the most excellent

technique for determining the structure of organic compounds. Of all the spectroscopic methods,

it is the only one for which a complete analysis and interpretation of the entire spectrum is

normally expected. To be successful in using NMR as an analytical tool, it is necessary to

understand the physical principles on which the methods are based. (IOCD, 2013)

NMR is a research technique that uses radiation in the radiofrequency region.

Mass Spectroscopy, Mass spectrometry has been expressed as the smallest scale in the world not

due to the mass of the spectrometers size but due to the size of what the molecule weighs. Over

the past decade, mass spectrophotometry has went through remarkable technological


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development so it can be applied to drugs,protein,DNA and a wide variety of biologically

important molecules. Mass spectrometry is the method of measuring atoms and molecules to find

out their molecular weight.

Raman Spectroscopy, Raman spectroscopy is classified as one of the most sensitive techniques

for sample analysis. Raman Spectroscopy, named after Indian physicist, Sir Chandrasekhara

Raman, involves the observation of the altering of wavelength and frequency of light as it

scatters the electrons of a particular medium. This phenomenon is known as the Raman Effect,

also named after Sir Raman (Collins, 2003).

Raman Spectroscopy applications and contributions to society are vast ranging from the

pharmaceutical industry and industrial chemistry to forensic sciences and art

Spectroscopic methods can be used to analyze and test various pharmaceutical drugs. For

example spectrophotometry can be used to analyze the drug aspirin to determine the amount of

acetylsalicylic acid present in the commercial product. Spectrophotometry is a technique used

to measure how much a chemical substance absorbs light by measuring the intensity of light as a

beam of light passes through sample solution. The basic principle involves each compound

absorbing or transmitting light over a certain range of wavelength. This measurement can also be

used to determine the amount of a known chemical substance. Spectrophotometry is one of the

most common and helpful methods of quantitative analysis in a variety of fields such as

chemistry, biochemistry, physics, and clinical applications. (Ucdavis n.d)

Reference


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Harper Collins. (2003). Collins English Dictionary.Harper Collins.

Harper Collins. (2003). Collins English Dictionary -Complete and Unbridged.Harper Collins.

IOCD, (2013) Nuclear Magnetic Resonance Spectroscopy retrieved from

http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/Spectrpy/nmr/nmr1.htm

Scripps Center(2014) Mass Spectrophotometry. Retrieved fromhttp://masspec.scripps.edu/mshistory/whatisms_details.php#Basics

Ucdavis(n.d)Spectrophotometry. Retrieved

fromhttp://chemwiki.ucdavis.edu/Physical_Chemistry/Kinetics/Reaction_Rates/Experimental_D

etermination_of_Kinetcs/Spectrophotometry
http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/Spectrpy/nmr/nmr1.htmhttp://masspec.scripps.edu/mshistory/whatisms_details.php#Basicshttp://masspec.scripps.edu/mshistory/whatisms_details.php#Basicshttp://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/Spectrpy/nmr/nmr1.htm

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