specification biotinylated polymeric probe (bp)t: (+649) 921 9710 19 mount st, auckland, new zealand...

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GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand www.GlycoNZ.com SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ polyacrylamide biotin conjugate _______________________________________________________________________________________ Catalogue ID number: Numéro d'identification du catalogue: 0600-BP Ligand & spacer: Glcβ1-3GlcNAcβ-OCH 2 CH 2 CH 2 NH 2 Product synonym: Produit synonyme: Glcβ3GlcNAcβ-C3-BP Glcβ3GlcNAcβ-C3-PAA-biot Glcβ1-3GlcNAcβ-C3-PAA-biot Glcβ1-3GlcNAcβ-sp3-PAA-biot Glcβ1-3GlcNAcβ-OCH 2 CH 2 CH 2 NH 2 -PAA-biot Common name of ligand: Nom commun de ligand: - Descriptive name: Nom descriptif: Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH 2 ) 5 )-acrylamide-co-N- (Glcβ3GlcNAcβ-C3)-acrylamide] MW of ligand & spacer: MW de ligand & spacer: 440.5 Da MW of glycoconjugate: MW de glycoconjugué: ~20 kDa TECHNICAL SPECIFICATION - Spécifications techniques Appearance: Apparence Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème Purity ( 1 H NMR): Pureté ( 1 H NMR): Min 95% Identity ( 1 H NMR): Identité ( 1 H NMR): Conforms to structure Conforme à la structure Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide] Ligand content: Contenu du ligand: 20% mol. Label: Étiquette Biotin Biotine Label content: Contenu de l'étiquette: 5% DOCUMENT CONTROL - Contrôle des documents Date of issue: Date d'Emission: 04-NOV-2019 Document ID: ID de document: 0600-BP-SPEC-191104

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Page 1: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0600-BP

Ligand & spacer: Glcβ1-3GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Glcβ3GlcNAcβ-C3-BP Glcβ3GlcNAcβ-C3-PAA-biot Glcβ1-3GlcNAcβ-C3-PAA-biot Glcβ1-3GlcNAcβ-sp3-PAA-biot Glcβ1-3GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: -

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Glcβ3GlcNAcβ-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

440.5 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0600-BP-SPEC-191104

Page 2: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Glcβ3GalNAcβ-C3-PAA-biot Glcβ3GalNAcβ polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0602-BP

Ligand & spacer: Glcβ1-3GalNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Glcβ3GalNAcβ-C3-BP Glcβ3GalNAcβ-C3-PAA-biot Glcβ1-3GalNAcβ-C3-PAA-biot Glcβ1-3GalNAcβ-sp3-PAA-biot Glcβ1-3GalNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: -

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Glcβ3GalNAcβ-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

440.5 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0602-BP-SPEC-191104

Page 3: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

GlcNAcβ2Galβ-C3-PAA-biot GlcNAcβ2Galβ polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0605-BP

Ligand & spacer: GlcNAcβ1-2Galβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

GlcNAcβ2Galβ-C3-BP GlcNAcβ2Galβ-C3-PAA-biot GlcNAcβ1-2Galβ-C3-PAA-biot GlcNAcβ1-2Galβ-sp3-PAA-biot GlcNAcβ1-2Galβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: -

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(GlcNAcβ2Galβ-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

440.5 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0605-BP-SPEC-191104

Page 4: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Fucβ2`Lec-C3-PAA-biot Fucβ2`Lec polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0607-BP

Ligand & spacer: Fucβ1-2Galβ-3GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Fucβ2`Lec-C3-BP Fucβ2`Lec-C3-PAA-biot Fucβ1-2Galβ-3GlcNAcβ-C3-PAA-biot Fucβ1-2Galβ-3GlcNAcβ-sp3-PAA-biot Fucβ1-2Galβ-3GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: -

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Fucβ2`Lec-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

586.6 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0607-BP-SPEC-191104

Page 5: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

GlcNAcβ4Galβ-C3-PAA-biot GlcNAcβ4Galβ polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0608-BP

Ligand & spacer: GlcNAcβ1-4Galβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

GlcNAcβ4Galβ-C3-BP GlcNAcβ4Galβ-C3-PAA-biot GlcNAcβ1-4Galβ-C3-PAA-biot GlcNAcβ1-4Galβ-sp3-PAA-biot GlcNAcβ1-4Galβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: -

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(GlcNAcβ4Galβ-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

440.5 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0608-BP-SPEC-191104

Page 6: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

6`,6-Bn2Lec-C3-PAA-biot Lec-6,6`-di-O-Bn polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0704-BP

Ligand & spacer: 6-O-Bn-Galβ1-3(6-O-Bn)GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

6`,6-Bn2Lec-C3-BP 6`,6-Bn2Lec-C3-PAA-biot Lec-6,6`-di-O-Bn-C3-BP Lec-6,6`-di-O-Bn-C3-PAA-biot 6-O-Bn-Galβ1-3(6-O-Bn)GlcNAcβ-C3-PAA-biot 6-O-Bn-Galβ1-3(6-O-Bn)GlcNAcβ-sp3-PAA-biot 6-O-Bn-Galβ1-3(6-O-Bn)GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: Lec-6,6`-di-O-Bn

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(6`,6-Bn2Lec-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

620.9 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0704-BP-SPEC-191104

Page 7: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Neu5Gcα3Galβ-C3-PAA-biot Neu5Gcα3Galβ polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0709-BP

Ligand & spacer: Neu5Gcα2-3Galβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Neu5Gcα3Galβ-C3-BP Neu5Gcα3Galβ-C3-PAA-biot Neu5Gcα2-3Galβ-C3-PAA-biot Neu5Gcα2-3Galβ-sp3-PAA-biot Neu5Gcα2-3Galβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: Neu5Gcα3Galβ

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Neu5Gcα3Galβ-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

544.5 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0709-BP-SPEC-191104

Page 8: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Atri3GalNAcβ-C3-PAA-biot A (type 4) polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0721-BP

Ligand & spacer: GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

A (type 4)-C3-BP A (type 4)-C3-PAA-biot Atri3GalNAcβ-C3-BP Atri3GalNAcβ-C3-PAA-biot GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ-C3-PAA-biot GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ-sp3-PAA-biot GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: A (type 4)

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Atri3GalNAcβ-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

789.8 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0721-BP-SPEC-191104

Page 9: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

GlcNAcα3GalNAcβ-C3-PAA-biot GlcNAcα3GalNAc polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0724-BP

Ligand & spacer: GlcNAcα1-3GalNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

GlcNAcα3GalNAcβ-C3-BP GlcNAcα3GalNAcβ-C3-PAA-biot GlcNAcα1-3GalNAcβ-C3-PAA-biot GlcNAcα1-3GalNAcβ-sp3-PAA-biot GlcNAcα1-3GalNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: GlcNAcα3GalNAc

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(GlcNAcα3GalNAcβ-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

481.5 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0724-BP-SPEC-191104

Page 10: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

L-Rhaβ-Gly-PAA-biot β-L-rhamnose polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0726-BP

Ligand & spacer: L-Rhaβ-NHCOCH2NH2

Product synonym: Produit synonyme:

L-Rhaβ-Gly-BP L-Rhaβ-Gly-PAA-biot L-Rhaβ-sp4-PAA-biot L-Rhaβ-NHCOCH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: β-L-rhamnose

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(L-Rhaβ-Gly)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

220.3 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0726-BP-SPEC-191104

Page 11: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

GlcNAcα-C3-PAA-biot α-D-N-acetylglucosamine polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0728-BP

Ligand & spacer: GlcNAcα-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

GlcNAcα-C3-BP GlcNAcα-C3-PAA-biot GlcNAcα-sp3-PAA-biot GlcNAcα-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: α-D-N-acetylglucosamine

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(GlcNAcα-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

278.3 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0728-BP-SPEC-191104

Page 12: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Neu5Gcα3`(6-su)Lec-C3-PAA-biot 6-Su-3`NeuGcLec polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0730-BP

Ligand & spacer: Neu5Gcα2-3Galβ1-3(6-O-Su)GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Neu5Gcα3`(6-su)Lec-C3-BP Neu5Gcα3`(6-su)Lec -C3-PAA-biot 6-Su-3`NeuGcLec-C3-BP 6-Su-3`NeuGcLec-C3-PAA-biot Neu5Gcα2-3Galβ1-3(6-O-Su)GlcNAcβ-C3-PAA-biot Neu5Gcα2-3Galβ1-3(6-O-Su)GlcNAcβ-sp3-PAA-biot Neu5Gcα2-3Galβ1-3(6-O-Su)GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: 6-Su-3`NeuGcLec

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Neu5Gcα3`(6-su)Lec-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

849.8 (Na) Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 04-NOV-2019

Document ID: ID de document: 0730-BP-SPEC-191104

Page 13: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Neu5Gcα3`(6-su)LN-C3-PAA-biot 6-Su-3`NeuGcLN polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0731-BP

Ligand & spacer: Neu5Gcα2-3Galβ1-4(6-O-Su)GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Neu5Gcα3`(6-su)LN-C3-BP Neu5Gcα3`(6-su)LN -C3-PAA-biot 6-Su-3`NeuGcLN-C3-BP 6-Su-3`NeuGcLN-C3-PAA-biot Neu5Gcα2-3Galβ1-4(6-O-Su)GlcNAcβ-C3-PAA-biot Neu5Gcα2-3Galβ1-4(6-O-Su)GlcNAcβ-sp3-PAA-biot Neu5Gcα2-3Galβ1-4(6-O-Su)GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: 6-Su-3`NeuGcLN

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Neu5Gcα3`(6-su)LN-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

849.8 (Na) Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0731-BP-SPEC-191107

Page 14: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

6`-BnLN-C2-PAA-biot LacNAc-6`-O-Bn polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0735-BP

Ligand & spacer: 6-O-Bn-Galβ1-4GlcNAcβ-OCH2CH2NH2

Product synonym: Produit synonyme:

6`-BnLN-C2-BP 6`-BnLN-C2-PAA-biot LacNAc-6`-O-Bn-C2-BP LacNAc-6`-O-Bn-C2-PAA-biot 6-O-Bn-Galβ1-4GlcNAcβ-C2-PAA-biot 6-O-Bn-Galβ1-4GlcNAcβ-sp2-PAA-biot 6-O-Bn-Galβ1-4GlcNAcβ-OCH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: LacNAc-6`-O-Bn

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(6`-BnLN-C2)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

516.6 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0735-BP-SPEC-191107

Page 15: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Xylβ-Gly-PAA-biot β-D-xylopyranose polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0736-BP

Ligand & spacer: Xylβ-NHCOCH2NH2

Product synonym: Produit synonyme:

Xylβ-Gly-BP Xylβ-Gly-PAA-biot Xylβ-sp4-PAA-biot Xylβ-NHCOCH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: β-D-xylopyranose

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Xylβ-Gly)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

206.2 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0736-BP-SPEC-191107

Page 16: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

L-Araα-Gly-PAA-biot α-L-arabinose polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0738-BP

Ligand & spacer: L-Araα-NHCOCH2NH2

Product synonym: Produit synonyme:

L-Araα-Gly-BP L-Araα-Gly-PAA-biot L-Araα-sp4-PAA-biot L-Araα-NHCOCH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: α-L-arabinose

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(L-Araα-Gly)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

206.2 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0738-BP-SPEC-191107

Page 17: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Fucβ2`LN-C3-PAA-biot Fucβ2`LN polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0740-BP

Ligand & spacer: Fucβ1-2Galβ1-4GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Fucβ2`LN-C3-BP Fucβ2`LN-C3-PAA-biot Fucβ1-2Galβ1-4GlcNAcβ-C3-PAA-biot Fucβ1-2Galβ1-4GlcNAcβ-sp3-PAA-biot Fucβ1-2Galβ1-4GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: -

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Fucβ2`LN-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

586.6 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0740-BP-SPEC-191107

Page 18: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Ribβ-Gly-PAA-biot β-D-ribose polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0744-BP

Ligand & spacer: Ribβ-NHCOCH2NH2

Product synonym: Produit synonyme:

Ribβ-Gly-BP Ribβ-Gly-PAA-biot Ribβ-sp4-PAA-biot Ribβ-NHCOCH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: β-D-ribose

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Ribβ-Gly)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

150.1 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0744-BP-SPEC-191107

Page 19: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Fucβ2`(Fucα3)LN-C3-PAA-biot Fucβ2`(Fucα3)LN polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0745-BP

Ligand & spacer: Fucβ1-2Galβ1-4(Fucα1-3)GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Fucβ2`(Fucα3)LN-C3-BP Fucβ2`(Fucα3)LN-C3-PAA-biot Fucβ1-2Galβ1-4(Fucα1-3)GlcNAcβ-C3-PAA-biot Fucβ1-2Galβ1-4(Fucα1-3)GlcNAcβ-sp3-PAA-biot Fucβ1-2Galβ1-4(Fucα1-3)GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: -

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Fucβ2`(Fucα3)LN-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

732.7 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0745-BP-SPEC-191107

Page 20: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

GalNAcα3`LN-C3-PAA-biot GalNAcα3`LN polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0747-BP

Ligand & spacer: GalNAcα1-3Galβ1-4GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

GalNAcα3`LN-C3-BP GalNAcα3`LN-C3-PAA-biot GalNAcα1-3Galβ1-4GlcNAcβ-C3-PAA-biot GalNAcα1-3Galβ1-4GlcNAcβ-sp3-PAA-biot GalNAcα1-3Galβ1-4GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: -

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(GalNAcα3`LN-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

643.6 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0747-BP-SPEC-191107

Page 21: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

GalNAcβ3`LN-C3-PAA-biot GalNAcβ3`LN polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0748-BP

Ligand & spacer: GalNAcβ1-3Galβ1-4GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

GalNAcβ3`LN-C3-BP GalNAcβ3`LN-C3-PAA-biot GalNAcβ1-3Galβ1-4GlcNAcβ-C3-PAA-biot GalNAcβ1-3Galβ1-4GlcNAcβ-sp3-PAA-biot GalNAcβ1-3Galβ1-4GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: -

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(GalNAcβ3`LN-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

643.6 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0748-BP-SPEC-191107

Page 22: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

GalNAcα3`Lex-C3-PAA-biot αGalNAcLex polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0755-BP

Ligand & spacer: GalNAcα1-3Galβ1-4(Fucα1-3)GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

GalNAcα3`Lex-C3-BP GalNAcα3`Lex-C3-PAA-biot αGalNAcLex-C3-BP

αGalNAcLex-C3-PAA-biot GalNAcα1-3Galβ1-4(Fucα1-3)GlcNAcβ-C3-PAA-biot GalNAcα1-3Galβ1-4(Fucα1-3)GlcNAcβ-sp3-PAA-biot GalNAcα1-3Galβ1-4(Fucα1-3)GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: αGalNAcLex

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(GalNAcα3`Lex-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

789.8 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0755-BP-SPEC-191107

Page 23: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Neu5Acα6`(Fucα2`)LN-C3-PAA-biot 6`SiaH(type 2) polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0757-BP

Ligand & spacer: Neu5Acα2-6(Fucα1-2)Galβ1-4GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Neu5Acα6`(Fucα2`)LN-C3-BP Neu5Acα6`(Fucα2`)LN-C3-PAA-biot 6`SiaH(type 2)-C3-BP

6`SiaH(type 2)-C3-PAA-biot Neu5Acα2-6(Fucα1-2)Galβ1-4GlcNAcβ-C3-PAA-biot Neu5Acα2-6(Fucα1-2)Galβ1-4GlcNAcβ-sp3-PAA-biot Neu5Acα2-6(Fucα1-2)Galβ1-4GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: 6`SiaH(type 2)

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Neu5Acα6`(Fucα2`)LN-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

877.9 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0757-BP-SPEC-191107

Page 24: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

6-suGalβ-C3-PAA-biot β-D-galactose-6-O-sulfate polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0762-BP

Ligand & spacer: 6-O-Su-Galβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

6-suGalβ-C3-BP 6-suGalβ-C3-PAA-biot β-D-galactose-6-O-sulfate-C3-BP β-D-galactose-6-O-sulfate-C3-PAA-biot 6-O-Su-Galβ-C3-PAA-biot 6-O-Su-Galβ-sp3-PAA-biot 6-O-Su-Galβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: β-D-galactose-6-O-sulfate

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(6-suGalβ-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

317.1 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0762-BP-SPEC-191107

Page 25: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Neu5Acα3`(6,6`-su2)LN-C3-PAA-biot 3`SLN-6,6`-di-O-sulfate polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0763-BP

Ligand & spacer: Neu5Acα2-3(6-O-Su)Galβ1-4(6-O-Su)GlcNAcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Neu5Acα3`(6,6`-su2)LN-C3-BP Neu5Acα3`(6,6`-su2)LN-C3-PAA-biot 3`SLN-6,6`-di-O-sulfate-C3-BP 3`SLN-6,6`-di-O-sulfate -C3-PAA-biot Neu5Acα2-3(6-O-Su)Galβ1-4(6-O-Su)GlcNAcβ-C3-PAA-biot Neu5Acα2-3(6-O-Su)Galβ1-4(6-O-Su)GlcNAcβ-sp3-PAA-biot Neu5Acα2-3(6-O-Su)Galβ1-4(6-O-Su)GlcNAcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: 3`SLN-6,6`-di-O-sulfate

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Neu5Acα3`(6,6`-su2)LN-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

923.8 (Na) Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0763-BP-SPEC-191107

Page 26: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

3-suGalNAcα-C3-PAA-biot Tn-3-O-sulfate polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0769-BP

Ligand & spacer: 3-O-Su-GalNAcα-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

3-suGalNAcα-C3-BP 3-suGalNAcα-C3-PAA-biot Tn-3-O-sulfate-C3-BP Tn-3-O-sulfate-C3-PAA-biot 3-O-Su-GalNAcα-C3-PAA-biot 3-O-Su-GalNAcα-sp3-PAA-biot 3-O-Su-GalNAcα-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: Tn-3-O-sulfate

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(3-suGalNAcα-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

358.4 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0769-BP-SPEC-191107

Page 27: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

GalNGcβ-C3-PAA-biot β-D-N-glycolylgalactosamine polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0770-BP

Ligand & spacer: GalNGcβ-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

GalNGcβ-C3-BP GalNGcβ-C3-PAA-biot GalNGcβ-sp3-PAA-biot GalNGcβ-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: β-D-N-glycolylgalactosamine

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(GalNGcβ-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

294.3 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0770-BP-SPEC-191107

Page 28: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Galβ3GalNGcα-C3-PAA-biot TF(Gc) polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0773-BP

Ligand & spacer: Galβ1-3GalNGcα-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Galβ3GalNGcα-C3-BP Galβ3GalNGcα-C3-PAA-biot TF(Gc)-C3-BP TF(Gc)-C3-PAA-biot Galβ1-3GalNGcα-C3-PAA-biot Galβ1-3GalNGcα-sp3-PAA-biot Galβ1-3GalNGcα-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: TF(Gc)

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Galβ3GalNGcα-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

456.5 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0773-BP-SPEC-191107

Page 29: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

4-suGalNAcα-C3-PAA-biot Tn-4-O-sulfate polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0778-BP

Ligand & spacer: 4-O-Su-GalNAcα-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

4-suGalNAcα-C3-BP 4-suGalNAcα-C3-PAA-biot Tn-4-O-sulfate-C3-BP Tn-4-O-sulfate-C3-PAA-biot 4-O-Su-GalNAcα-C3-PAA-biot 4-O-Su-GalNAcα-sp3-PAA-biot 4-O-Su-GalNAcα-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: Tn-4-O-sulfate

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(4-suGalNAcα-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

358.4 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0778-BP-SPEC-191107

Page 30: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Neu5Acα3`(6`-su)TF-C3-PAA-biot 3`SiaTF-6`-O-sulfate polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0785-BP

Ligand & spacer: Neu5Acα2-3(6-O-Su)Galβ1-3GalNAcα-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Neu5Acα3`(6`-su)TF-C3-BP Neu5Acα3`(6`-su)TF-C3-PAA-biot 3`SiaTF-6`-O-sulfate-C3-BP 3`SiaTF-6`-O-sulfate-C3-PAA-biot Neu5Acα2-3(6-O-Su)Galβ1-3GalNAcα-C3-PAA-biot Neu5Acα2-3(6-O-Su)Galβ1-3GalNAcα-sp3-PAA-biot Neu5Acα2-3(6-O-Su)Galβ1-3GalNAcα-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: 3`SiaTF-6`-O-sulfate

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Neu5Acα3`(6`-su)TF-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

833.8 (Na) Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0785-BP-SPEC-191107

Page 31: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Lec3GalNAcα-C3-PAA-biot Lec3Tn polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0786-BP

Ligand & spacer: Galβ1-3GlcNAcβ1-3GalNAcα-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

Lec3GalNAcα-C3-BP Lec3GalNAcα-C3-PAA-biot Lec3Tn-C3-BP Lec3Tn-C3-PAA-biot Galβ1-3GlcNAcβ1-3GalNAcα-C3-PAA-biot Galβ1-3GlcNAcβ1-3GalNAcα-sp3-PAA-biot Galβ1-3GlcNAcβ1-3GalNAcα-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: Lec3Tn

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Lec3GalNAcα-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

643.6 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0786-BP-SPEC-191107

Page 32: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

6-suTF-C3-PAA-biot TF-6-O-sulphate polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0789-BP

Ligand & spacer: Galβ1-4(6-O-Su)GalNAcα-OCH2CH2CH2NH2

Product synonym: Produit synonyme:

6-suTF-C3-BP 6-suTF-C3-PAA-biot TF-6-O-sulphate-C3-BP TF-6-O-sulphate-C3-PAA-biot Galβ1-4(6-O-Su)GalNAcα-C3-PAA-biot Galβ1-4(6-O-Su)GalNAcα-sp3-PAA-biot Galβ1-4(6-O-Su)GalNAcα-OCH2CH2CH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: TF-6-O-sulphate

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(6-suTF-C3)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

520.5 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0789-BP-SPEC-191107

Page 33: SPECIFICATION Biotinylated polymeric probe (BP)t: (+649) 921 9710 19 Mount St, Auckland, New Zealand SPECIFICATION Biotinylated polymeric probe (BP) Glcβ3GlcNAcβ-C3-PAA-biot Glcβ3GlcNAcβ

GlycoNZ Ltd – a subsidiary of Kode Biotech Ltd GlycoNZ Limited PO Box 5965, Wellesley St, Auckland 1141, New Zealand Scott Laboratory Building – AUT University t: (+649) 921 9710 19 Mount St, Auckland, New Zealand

www.GlycoNZ.com

SPECIFICATION Biotinylated polymeric probe (BP)

Fucβ-Gly-PAA-biot β-L-fucose polyacrylamide biotin conjugate

_______________________________________________________________________________________

Catalogue ID number: Numéro d'identification du catalogue: 0799-BP

Ligand & spacer: Fucβ-NHCOCH2NH2

Product synonym: Produit synonyme:

Fucβ-Gly-BP Fucβ-Gly-PAA-biot β-L-fucose-Gly-BP β-L-fucose-Gly-PAA-biot Fucβ-sp4-PAA-biot Fucβ-NHCOCH2NH2-PAA-biot

Common name of ligand: Nom commun de ligand: β-L-fucose

Descriptive name: Nom descriptif:

Poly[N-(2-hydroxyethyl)acrylamide-co-N-(biot-(CH2)5)-acrylamide-co-N-(Fucβ-Gly)-acrylamide]

MW of ligand & spacer: MW de ligand & spacer:

220.3 Da

MW of glycoconjugate: MW de glycoconjugué: ~20 kDa

TECHNICAL SPECIFICATION - Spécifications techniques

Appearance: Apparence

Off-white to cream lyophilized powder Poudre lyophilisée blanc cassé à crème

Purity (1H NMR): Pureté (1H NMR): Min 95%

Identity (1H NMR): Identité (1H NMR):

Conforms to structure Conforme à la structure

Backbone: Colonne vertébrale: Poly[N-(2-hydroxyethyl)acrylamide-co-N-acrylamide]

Ligand content: Contenu du ligand: 20% mol.

Label: Étiquette

Biotin Biotine

Label content: Contenu de l'étiquette: 5%

DOCUMENT CONTROL - Contrôle des documents

Date of issue: Date d'Emission: 07-NOV-2019

Document ID: ID de document: 0799-BP-SPEC-191107