specie: anopheles gambiae pest genome size: 260 mb status: 3rd assembly and annotation niaid funded

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Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

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Page 1: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Specie: Anopheles gambiae PESTGenome size: 260 MbStatus: 3rd assembly and annotationNIAID funded

Page 2: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Species: Aedes aegypti LiverpoolGenome size: 1.3 GbStatus: 1st assembly and annotationNIAID funded

Page 3: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Species: Culex pipiens quinquefasciatus JHBGenome size: 540 MbStatus: Shotgun sequencing completed ~8 XNIAID funded

Page 4: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Species: Ixodes scapularis WIKELGenome size: 2.1 GbStatus: Shotgun sequencing in progress ~4 XNIAID funded

Page 5: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Species: Peduculus humanus humanusGenome size: 100 MbStatus: Shotgun sequencing completed, ~8 XNHGRI funded

Page 6: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Species: Glossina morsitans morsitansGenome size: 500-600 Mb (~7 Gb ??)Status: ~3 X coverage approved, > 40 K EST availableSanger Center

Page 7: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Species: Phlebotomus papatasi, Lutzomyia longipalpisGenome size: Pp, ~170 MB, Ll ~ 300 Mb Status: BAC end and ESTs in progress, > 30 K EST avail.NHGRI and Sanger Center

Page 8: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Species: Rhodnius prolixusGenome size: 670 MbStatus: Preliminary analysis of genomic DNANHGRI funded

Page 9: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Species: Anopheles gambiae M and S Forms (6-10 other Anopheles spp. pending)

Genome size: 260 MbStatus: Shotgun sequencing in progressNHGRI funded

Page 10: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Genome-specific Curation

• Anopheles gambiae PEST - Kitsos Louis

• Aedes aegypti - Neil Lobo

• Culex pipiens - Peter Arensburger

• Ixodes scapularis - Cate Hill

• Anopheles gambiae M/S - Nora Besansky

• Other species - lead authors of white papers

Page 11: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Discussion of Morning Topics

1. Too many genomes

2. VectorBase web site view

3. VectorBase web site content

4. AnoBase integration

5. EST data independent of genomes

6. CVs

7. Expression/array data

Page 12: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded
Page 13: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded
Page 14: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Population Data

1. Insecticide resistance data: High priority, directly linked to genomes

2. Population genetics data: Marker sets and population genetics data sets, directly linked to genomes

3. Population genetics of other species for which genomes are not available

4. Epidemiological/Ecological data: Parallel development by malaria groups in Africa

5. Vector and parasite population data

Page 15: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Malaria Monitoring and Control Consortium (BMGF)

• Malaria vector transmission and ecology data from 6 countries

• Core malaria vector data sets to drive malaria simulation models

• BMGF and MMCC objective of common data repository and format

Page 16: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

• Population Data versus Genome Data

Page 17: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Specie: Sabethes cyaneusGenome size:Status:

Page 18: Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded

Specie: Trypteroides bambusaGenome size:Status: