southwestern medical perspectives fall 2015

75 Years of VisionThe Lasting Gift of Southwestern Medical Foundation

Part I I: 1980 to 1999Hearts (and Minds) of Gold

The Nobel Prize ( actual size )

Hearts and Minds

The lasting gift of Southwestern Medical Foundation began in the

heart and mind of Dr. Edward H. Cary. But for it to grow into something truly

remarkable, many people – extraordinary people with generous hearts and

brilliant minds – had to become convinced of its noble cause.

And as they were, one by one, something important happened. A tipping

point was reached, when it was no longer a question of “will we make it?”

but rather “how far will we go?”

Such was the transition for the Foundation and the medical school between

the years 1980 and 1999. It was an exceptional 20 years – a period of time when

a quality medical school became a magnet in our community for generous hearts

and was able to attract from the world many of its most brilliant medical minds.

In a sense, it was a golden era.

Hearts of gold were found in generous donors determined to elevate the

human spirit by helping to end human suffering. And exceptional minds struck

gold – not once, but four times – in the form of science’s highest achievement:

the Nobel Prize, awarded to researchers whose curiosity challenged them to ask

farsighted questions and then, incredibly, answer them.

Lastly, during this period Southwestern Medical Foundation celebrated its

golden anniversary – 50 years of unprecedented achievement and support.

Because this community of extraordinary people worked together, we

shouldn’t be surprised at the outcome: the establishment of an academic medical

center second to none.

Our feature story is not meant to be an exhaustive recounting of our history.

It is, rather, an opportunity to retell a few stories of people and impact, of community

support and results, of inspiring vision coming to fruition in a remarkably short

period of time.

In producing this issue, two things became readily apparent: 1) There is so much history

to tell that we cannot possibly begin to tell it all, and 2) We know there are more wonderful

stories that deserve to be told.

I want to invite you to contribute your stories to add to the rich history of the Foundation

as we continue to explore our archives and make plans to publish new stories as they are known.

On the back cover you will learn more about how you can share your recollections with us.

Thank you beyond measure for your friendship and support.

Kathleen M. Gibson

Pres ident

ShareCAPTURE A MEMORY

pay tribute

rememberINSPIRE

MAKE A DIFFERENCE

reminisceHONORADD

YOUR VOICE

Edward M. Ackerman Sara Melnick AlbertRuth Sharp AltshulerBarry AndrewsGilbert AranzaMarilyn H. AugurDavid W. BieglerGene H. BishopAlbert C. Black, Jr.George W. Bramblett, Jr.Daniel H. BranchJean Ann BrockStuart M. BumpasEdward H. Cary, IIIDan W. Cook, IIIBerry R. CoxEdwin R. DanielsJoe D. DentonRobert J. DiNicolaThomas M. Dunning

Thomas J. EngibousRobert T. Enloe, IIIJerry FarringtonRobert I. FernandezLee FikesDavid L. FlorenceEdwin S. Flores, PhDTerry J. Flowers, EdDRobert S. FolsomGerald J. FordGerald W. FronterhousePrintice L. GaryWilliam R. Goff Joe M. Haggar, III Howard HallamCharles M. Hansen, Jr.Joe V. Hawn, Jr.Frederick B. HegiThomas O. HicksLyda Hill

Laurence E. HirschJames M. HoakSally S. HoglundKeith W. HughesWalter J. HumannRay L. HuntPhilip R. JonssonDarrell E. JordanDale V. KeslerGary KusinDavid M. Laney Wright L. Lassiter, Jr., EdDThomas C. LeppertIrvin L. LevyJohn I. LevyWendy A. Lopez Sarah LosingerWales H. Madden, Jr.Ann E. MargolinMargaret McDermott

John D. McStay Mike A. MyersHarvey R. MitchellW. A. “Tex” Moncrief, Jr.Susan Byrne MontgomeryCipriano MunozJ. Fulton Murray, Jr.Joseph B. NeuhoffJack Pew, Jr.J. Blake PogueKathryn PriddyCaren H. ProthroMary Stewart RamseyLeonard M. Riggs, Jr., MDJean W. Roach John L. RoachLizzie Horchow RoutmanPete SchenkelJohn Field ScovellPaul R. Seegers

Carl Sewell, Jr.Lisa K. SimmonsRoger T. StaubachPaul T. StoffelJoanne H. Stroud, PhDJ. Liener TemerlinEllen C. TerryGifford O. TouchstoneJim L. TurnerJack C. Vaughn, Jr.John J. Veatch, Jr.Kent WaldrepW. Ray WallaceJimmy WestcottLaura L. WheatJon B. WhiteEvelyn Whitman-DunnTerry M. Wilson Donald Zale

HONORARY TRUSTEES

John L. AdamsRafael M. AnchiaCharles Anderson Charlotte Jones AndersonRalph W. Babb, Jr.Alice Worsham BassDoris L. BassPeter BeckJill C. BeeGil J. BesingRobert W. Best*Jan Hart BlackCecilia G. BooneDiane M. BrierleyRobert W. Brown, MDLeland R. Burk Stephen ButtW. Plack Carr, Jr.Jeffrey A. ChapmanNita P. ClarkRita C. Clements*Mary McDermott Cook*David R. CorriganHarlan R. Crow*Robert H. Dedman, Jr.Joseph M. DePinto

Jennifer EagleTimothy EllerMatrice Ellis-KirkSandra Street EstessRobert A. EstradaRoy Gene EvansAndersen C. FisherRichard W. Fisher Stuart FittsKay Carter FortsonAlan D. FriedmanJudy GibbsKathleen M. GibsonMarshal D. Goldberg, DDS, MSJoseph M. ( Jody) GrantSatish GuptaRolf R. Haberecht, PhDRonald W. HaddockNancy S. Halbreich*David C. HaleyKathryn W. HallLaQuita C. HallPaul W. HarrisLinda W. Hart*Jeffrey M. Heller

Julie K. HershJ. Hale HoakRichard E. Hoffman, MD David B. HollT. Curtis Holmes, Jr.*James R. HuffinesHunter L. HuntKay Bailey HutchisonRex V. JobeEric JohnsonJudith K. JohnsonRobert L. KaminskiGary C. Kelly Harlan KorenvaesPeter A. KrausLaurence H. LebowitzSamuel D. LoughlinBobby B. LyleS. Todd MaclinGloria Eulich MartindaleWilliam S. McIntyre, IVPauline MedranoHoward M. MeyersDavid B. MillerKay Y. MoranJennifer T. Mosle

Charles E. NearburgRay Nixon, Jr.James C. OberwetterTeresa Haggerty ParravanoLee Ann Pearse, MDCarlos G. PeñaGuillermo PeralesT. Boone Pickens*Daniel K. Podolsky, MDRichard R. PollockTodd A. Pollock, MDCarolyn Perot RathjenMichael S. RawlingsKelly E. RoachLinda Robuck*Catherine M. RoseMatthew K. RoseWilliam E. “Billy” Rosenthal*Robert B. RowlingStephen SandsSteven S. Schiff Robert J. SchlegelGeorge E. SeayDebbie Scripps George A. ShaferFlorence Shapiro

Karen L. ShufordTed C. SkokosNicole G. Small Emmitt J. Smith*William T. SolomonWilliam S. Spears, PhDCatherine B. TaylorRichard K. TempletonMichelle R. Thomas*Jere W. Thompson, Jr.McHenry T. TichenorJohn C. TollesonLisa TrouttW. Kelvin Walker*J. Thomas Walter, Jr.Jim W. Walton, DOKelcy L. WarrenCarol R. WestGeorge W. Wharton, MDKern Wildenthal, MD, PhDMartha S. WilliamsKneeland C. Youngblood, MD* Executive Committee

BOARD OF TRUSTEES

Robert B. Rowling, ChairmanKathleen M. Gibson, PresidentDonald W. Seldin, MD, VP – Medical Center Relations

OFFICERS

Brian Grosheider, VP – FinanceKaty Sinor, Secretary

2

Southwestern Medical Foundation Officers, Trustees and Honorary Trustees

7 5 Y E A R S O F V I S I O N : T H E L A S T I N G G I F T

EDITOR

Kim Brayton the BraytonGroup

EDITORIAL / RESEARCHDIRECTOR

Traci Beeson

CREATIVE / DESIGNDIRECTOR

Kim Brayton

WRITERS

Kim Brayton

Various authors and sources*

Randal Daugherty

PHOTOGRAPHERS

Archival resources*

David Gresham

Steve Foxall

* see page 95

Editorial comments and contributions are welcome.Send correspondence to:

Southwestern Medical FoundationParkland Hall at Old Parkland3889 Maple Avenue, Suite 100Dallas, Texas 75219

[email protected] 214-351- 6143f 214-352-9874

contents

A Defining Decade 1980 to 1989Aided by support from the Foundation and growing interest from the Dallas philanthropic community, the medical school gains international acclaim with three Nobel Prize winners. Advances inbiomedical science accelerate our understanding of the mechanisms of health and disease, while the idea of disease prevention firmly enters the public consciousness. Despite unexpected economic challenges, it is a decade of remarkable achievement.

4

By Leaps and Bounds 1990 to 1999An unprecedented fundraising drive significantly accelerates thedevelopment of the North Campus and marks the start of a significant leap forward in biomedical research. The medical school makes a solid contribution to the most remarkable scientific project ever undertaken by mankind. An important clinical initiative comes of age as the promise of Zale Lipshy Hospital becomes a reality, and a fourth Nobel Prize is won.

40

75 Years of Vision Part II: 1980 to 1999

68 A Grand CelebrationThe Foundation celebrates its 75th anniversary in style.

80 33 Years of WisdomWilliam T. Solomon is honored for over three decades of service.

1 President’s Letter

92 In The NewsUT Southwestern medical students thank their benefactors, the Foundation donates $7.5 million to UT Southwestern to help further global leadership in neuroscience, and an Ida M. Green Visiting Professor continues to inspire women in biomedical science.

96 A Moment in Time

Cover Story

Features

Every Issue

3S O U T H W E S T E R N M E D I C A L P E R S P E C T I V E S . F A L L 2 0 1 5

84 What’s NextThe second and third programs in the Foundation’s “Leading the Conversation on Health” series.

86 Annual MeetingRobert B. Rowling is electedChairman of the Foundation.

82 Legacy of GivingLooking back on bequests made in the 1980s and 1990s.

88 New Trustees2014 –2015 Trustees are recognized for their leadership, and 2015 –2016Trustees are announced.


“What shines through all this work is a dedication to quality, an unrelenting

drive to do workof the highest caliber,

with an imaginative overtone – so that the studies do not

simply repeat the work of others but forge

new domains of learning.”Donald M. Seldin, MD

Chairman of Internal Medicine, Southwestern Medical SchoolThe University of Texas Health Science Center at Dallas

(at the time)

n December 9, 1979, a commission of eminent scientists certified the globaleradication of smallpox — which was later endorsed by the World Health Assembly

on May 8, 1980. Beyond ending centuries of human suffering, it was an iconic testament to what medical science could achieve. A disease that had ravaged the world, the nation and the city of Dallas just 90 years ago was no more. Gone, too, were many archaic and naive notions of disease and patient care.

In their place, revolutionary advances in biomedical science were accelerating our understanding of the mechanisms of human health and disease. Nothing seemed impossible since the imagination-igniting discovery of DNA. Molecular biology — a convergence of biochemistry, genetics, microbiology, virology and physics — had become a powerful platform from which to understand disease and seemed to hold unlimited potential for improving human health. In academic circles across the country, UT Southwestern was beginning to be recognized as a premier, research-intensive

medical school. In Dallas, the medical center was committed to making public health and community outreach a central component of its mission. By 1980, hundreds of its clinicians were the practicing faculty at Parkland, Children’s Medical Center, Scottish Rite and the Veteran’s Administration Hospital. Southwestern Medical Foundation, after founding and nurturing the medical school’s development for nearly four decades, was a conduit to promote the school to the Dallas business and philanthropic communities. Charles C. Sprague, MD, President of the Medical Center, observed that annual grants from the Foundation “enabled the school to bring to its staff and to hold some of the best of the nation’s medical teaching and medical research talent.”

A team of UT Southwestern physicians performing surgery at Parkland. By 1980, medical school faculty were teaching and practicing medicine at Parkland, Children’s Medical Center, Scottish Rite and the VA Hospital.



A DEFINING DECADE

1 9 8 0 T O 1 9 8 9

O

The molecular basis of biological activity became essential to understanding the nature of disease.

Led by Donald Seldin, MD, the Department of Internal Medicine had risen to a position of preeminence and was internationally respected. Encouraged by Seldin and Sprague, the departments of biochemistry, cell biology, microbiology and physiology were thriving. In 1979, Joseph Goldstein, MD, Chairman of the Department of Molecular Genetics, approached Alfred G. Gilman, MD, PhD, who was working at the University of Virginia School of Medicine, about a position as Chairman of the Department of Pharmacology. The two had been postdoctoral fellows in the same lab at the National Institutes of Health a decade earlier. At the time, Gilman was immersed in research and editing the sixth edition of the famous text his father had co-authored: Goodman and Gilman’s The Pharmacological Basis of Therapeutics, long considered the “bible” of pharmacology textbooks. “I was working my tail off on the book and was much too busy to even think about a new job,” Gilman said. Then in 1981, Seldin came calling. “Very few say no to Dr. Seldin,” Gilman recalled, “and I arrived in Dallas to chair the Department of Pharmacology.” Gilman in turn was able to attract top researchers, elevating his department to among the best in the country.

hile many people carried the cause of the medical school forward in the 1980s, for decades to come, as it had for decades prior, UT Southwestern would owe much to the passion and personality of Philip O’Bryan (P. O’B.) Montgomery, Jr., MD. Dr. Montgomery was a Professor of Pathology and Associate Dean. Early in his career, he had attracted the attention of the research world by being among the first to characterize fibrinoid, the change in the blood vessel walls of people with high blood pressure. Peter O’Donnell’s first involvement with UT Southwestern came in the mid-1950s when Montgomery approached him for help in purchasing equipment. A friend of Montgomery's from high school, O’Donnell and his wife Edith had by now transformed their collective wealth — his success as a securities investor and her inheritance — into the O’Donnell Foundation.

6

The most universal and respected

medical text in pharmacology, The Pharmacological Basis of Therapeutics

by Goodman and Gilman is used

for the effective prescribing of drugs

in daily medicine and considered

the “bible of pharmacology.”

It was co-authored by Louis S.

Goodman, MD, and Alfred Gilman,

PhD (shown at left), of Yale University

School of Medicine.

First published in 1941, the book is

in its 12th edition. Physicians of all

therapeutic and surgical specialties,

clinical pharmacologists, clinical

research professionals and pharmacists

rely on the book.

Gilman named his son Alfred

Goodman Gilman, who became Chair of

the Department of Pharmacology

at UT Southwestern in 1981. Michael

Brown, MD, once quipped that Gilman

(the son) “ is probably the only person

who was ever named after a textbook.”

Alfred G. Gilman, MD, PhD, served

as primary editor of the textbook in

1980, 1985 and 1990.

Alfred Gilman, PhD, father of Alfred G. Gilman, MD, PhD, and co-author of Goodman and Gilman’sThe Pharmacological Basis of Therapeutics. The title page shown is from the first edition.


Don Seldin, MD, with students.

W



Kern Wildenthal, MD, PhD, succeeds Fred Bonte, MD, as Dean of the Medical School. At 38, Wildenthal is the youngest dean of any American medical school.____________

____________

____________Roger Unger, MD, Professor of Internal Medicine, is awarded the Claude Bernard Medal, the highest award given by the European Association for the Study of Diabetes.____________UT System Board of Regents approves new building projects, including an ambulatory care teaching center and two additional floors of the Fred F. Florence Bioinformation Center.____________ Emmet J. Conrad, MD, the first African-American surgeon on the staff of St. Paul Hospital, is elected Chief of Staff.

After stepping down as Dean of the Medical School, a position he had held

since 1973, Fred Bonte, MD, becomes head of the newly established Center

for Nuclear Medicine. Nuclear medicine scanners had made it possible to study

blood flow in a noninvasive manner, especially following a stroke. From 1980,

Bonte served as the Director of the Nuclear Medicine Center. He is currently a

Senior Investigator with the Alzheimer’s Disease Center.

Frederick J. Bonte, MD

William B. Neaves, PhD, is appointed Dean of the UT Southwestern

Graduate School of Biomedical Sciences. Neaves began his career at

the medical school in 1972 as an Assistant Professor in Cell Biology.

“I’d never been to a place where there was a greater sense of

community spirit and a sort of delight in what each was doing and

the successes that one’s colleagues were achieving,” he says.

William B. Neaves, PhD

1 9 8 0

Elsewhere in the world, Frederick Sanger, PhD, a British biochemist, wins the Nobel Prize in Chemistry for developing a method to sequence DNA molecules, known as the “Sanger Method.” It is a major breakthrough that allows long stretches of DNA to be rapidly and accurately sequenced. It is a foretaste of things to come.

Frederick Sanger, PhD


8

Among other notable civic and business leaders, William T. Solomon joins the board of Southwestern Medical Foundation.____________

____________UT Southwestern forms the Center for Human Nutrition, jointly funded by the medical school and the O’Donnell Foundation.____________ Morris Ziff, MD, is named first Ashbel Smith Professor, the highest academic tribute in the UT System.____________Dallas County taxpayers approve a major expansion and enhancement of Parkland Memorial Hospital, the primary teaching site of UT Southwestern, enabling a significant upgrade of clinical services.

In 1981, a group of women in Dallas commit themselves to

taking on heart disease by initiating the Sweetheart Ball, which

becomes one of the most prestigious charity events in Dallas.

Proceeds from the Sweetheart Ball’s early years establish

the Gail Griffiths Hill Chair in Cardiology at UT Southwestern,

named for a founding member of the group. Later, the funds are

directed to the Sweetheart Ball Fund for Cardiology Research.

The endowment fuels the search for new therapies to

prevent and cure heart disease, including treatments for those

genetically predisposed.

Since its inception, the Sweetheart Ball has raised more than

$22 million for cardiovascular research at UT Southwestern.

The Gail Griffiths Hill Chair in Cardiology, established by proceeds from the Sweetheart Ball, is currently held by Sharon Reimold, MD.

1 9 8 1

Philip O’Bryan “P. O’B.” Montgomery, Jr., MD, came to Southwestern Medical School to practice and teach pathology in 1952. Montgomery played a central role in developing the Department of Pathology.



Later on, Montgomery needed funding to pursue his ideas for research and education. He reached out to Eugene McDermott, a family friend and co-founder of Texas Instruments. Montgomery had made lasting friendships with McDermott and had introduced Cecil Green and Erik Jonsson to the medical school as well — all three men who had founded Texas Instruments. With his genuinely caring nature and endearing enthusiasm, Montgomery formed meaningful relationships with the three men, their wives and families that would have a profound impact on the school’s development for years to come. Montgomery possessed a keen eye for talent. O’Donnell recalls that in 1980 Montgomery told him, “Brown and Goldstein will win the Nobel Prize.” “I watched my friend Phil Montgomery devote half a century to serving UT Southwestern....He recruited students and faculty and planned campuses. He was a money-raiser and a money-giver. He was knowledgeable, analytical, scientific, attentive and caring. In short, he was a perfect doctor,” O’Donnell said.

y 1980, the population of Dallas had reached 900,000, doubling in size since Parkland had first opened its doors in 1954 on a site adjacent to the medical school campus. Over the years, the rapid growth exceeded the funding required. A tipping point had nowbeen reached and, as a result, Parkland entered a period of rapid decline. The public hospital’s financial resources had been tapped. Funding to upgrade the facilities, let alone properly maintain them, wasn’t available, nor was there money to add nursing and janitorial staff. Parkland’s deterioration also put the medical school in a precarious situation. For decades, Parkland had added tremendous value as a teaching hospital, but as it continued to struggle financially, many of the school’s top clinicians began to leave. The situation was dire.

Dallas went from the 22nd largest city in the country in 1950 to the 7th largest city by 1980.

1950

1960

1970

1980

434,462

679,684

844,401

904,078

City of Dallas Population

“I believe Charlie Sprague reached the high point of his many years of exemplary leadership when he made the decision to reach out to

the community for help in reversing the deterioration of Parkland.” Kern Wildenthal, MD, PhD President Emeritus of the Medical Center

B

Sprague emerged to mobilize Dallas. He spoke to the Dallas Citizen’s Council and the Dallas Chamber of Commerce. He involved civic leaders Ralph Rogers and Erik Jonsson; later, Kay Bailey Hutchinson and Paul Bass helped engage political and business leaders. The community was stepping forward, together. The Dallas Morning News and Dallas Times Herald promoted the idea that restoring Parkland was critical. The newspapers not only explained the problem but helped to educate

the public on what could easily have been seen as an unpopular solution — raising taxes to increase Parkland’s annual budget. The Citizen’s Council, led by Rogers, assessed the severity of the situation and recommended an $80 million bond issue to upgrade the hospital. With the passing of the bond issue, Rogers would add helping to save Parkland Hospital to his long list of notable accomplishments. Once new political leadership and new funding was put into place, Parkland began to reverse its downward trend almost overnight. “If the community hadn’t acted as quickly as it did to reinvigorate Parkland, the medical school, as well as the hospital, would have been seriously damaged,” Wildenthal said.

hile the genetic and molecular basis for understanding the nature of disease had captured enormous scientific interest, another way of thinking about human health had solidly emerged: that of prevention. Perceptions of what constituted a healthy lifestyle were evolving. No longer were people who ate fresh fruits, vegetables and whole-grain bread considered “health nuts.” It now seemed common sense that people who ate and drank in moderation, didn’t smoke and exercised regularly had a better chance to live out their natural lifespan. In London, a noted epidemiologist named Geoffrey Rose asserted that the Western diet, high in fat and salt and low in fiber, was responsible for the growing epidemic of heart disease. By the start of the 1980s, many Americans had come to believe that fat — particularly the saturated fat found in meat and dairy products — was the primary problem with their diet. Studies from around the world spawned countless theories and books on diet and nutrition and their various effects on disease prevention and overall health.


10

Ralph B. Rogers was an American industrialist,

philanthropist and PBS executive, called the “Founding

Father of the Public Broadcasting Service.”

During World War II, he contracted rheumatic

fever and discovered during his 14 months of fighting

the disease that it was responsible for killing more

children than all other children’s diseases combined.

“I refuse to accept that this massive illness cannot

be conquered,” he said at the time.

He raised money, enlisted the support of drug

companies and laboratories, and found scientists

who would accept his financial help to work on the

disease. Eventually this effort led to the discovery

that the disease was linked to strep throat. Through

the development of antibiotics, rheumatic fever

was all but wiped out.

After World War II, he moved to Texas and built

Kenilworth Corporation, which later became Texas

Industries, a concrete and building materials firm.

Rogers retired in 1975 but continued to pursue

philanthropic activities and civic causes, especially

medicine and education. In Dallas, he was credited

with saving the Dallas Symphony Orchestra.

Ralph B. Rogers

W



A gift of $100,000 from Southwestern Medical Foundation establishes the Charles Cameron SpragueDistinguished Chair in Biomedical Science in honor of Dr. Sprague’s 15th anniversary at UT Southwestern. The gift is made with the intent to grow it to $500,000 over the next 5 years.____________Drs. Jonathan Uhr and Ellen Vitetta report in Nature the results of their study of a cancer-seeking antibody that removes cancer cells from the bone marrow of mice.

Ralph Rogers, working as Parkland’s Board Chairman, asks Ron Anderson, MD, an Associate Professor of Internal Medicine and Medical Director of Parkland’s emergency room, to take the helm. The request follows the approval of Dallas County taxpayers for an $80 million bond offering that will expand and reinvigorate Parkland’s aging facilities. Anderson initially turns him down, but Rogers convinces him that rather than caring for a few people each day he could care for hundreds and influence the health care of hundreds of thousands more. Anderson promises Rogers five years but goes on to tirelessly champion the rights of all Dallas citizens to receive quality health care for the next 29 years. Under his leadership, Parkland becomes known as one of the finest public hospitals in the country, a center of excellence for the treatment of trauma and burn victims, and receives national acclaim for its community outreach programs. In 1997, Anderson recalled that Rogers called him to his bedside as he lay dying: “I know I’ve just got another couple of days, but I want to talk to you. I think you made a really good decision...how many years has it been now — that five years?” Anderson told him it’d been 17 years. Rogers continued, “I wanted you to know before I die that I was right,” and then added, “Now go on.”

Ron Anderson, MD, in front of Parkland’s emergency entrance.

“...Dr. Ron Anderson’s dedication to the needs of the most

vulnerable of our community was unwavering. Through his stewardship of Parkland, in partnership with the physicians of UT Southwestern,

legions have received care and comfort not available to them otherwise.” Daniel K. Podolsky, MD President, UT Southwestern

1 9 8 2


12

For Southwestern Medical Foundation, George L. MacGregor is elected Chairman Emeritus, James W. Aston is elected Chairman and James W. Keay is elected President.____________A challenge grant by Southwestern Medical Foundation is matched by the Meadows Foundation to establish a state-of-the-art cardiac laboratory at Parkland Hospital.____________

____________

Ann and Charles A. Sanders, MD

Southwestern Medical Foundation establishes a

$100,000 scholarship fund honoring the late Harold

B. Sanders, Sr., who was an original member of

the Board of Trustees, serving for 41 years and as its

general counsel for 35 years.

His son, Charles A. Sanders, MD, was a 1955

graduate of UT Southwestern and would later become

Chairman and CEO of Glaxo Inc., a leading research-

based pharmaceutical firm.

“UT Southwestern is the institution that shaped me

as a physician, and I will always be very grateful for the

wonderful experiences it afforded me,” Dr. Sanders said.

Dr. Sanders' brother, Judge Barefoot Sanders, would

preside over the desegregation of Dallas Independent

School District.

As a result of lobbying by George Buchanan, MD, UT Southwestern

Professor of Pediatrics, and Donald Fernbach, MD, then Chief of

Hematology and Oncology at Houston’s Texas Children’s Hospital,

the State of Texas begins screening all newborn babies for sickle

cell disease. The screening proves extremely accurate and allows for

early, preventive measures critical to extending life.

George Buchanan, MD

1 9 8 3

Two separate research groups, an American team at the National Cancer Institute and a French team at the Pasteur Institute in Paris, independently declare that a novel retrovirus may have been infecting AIDS patients. The two viruses turn out to be the same, and in 1986, LAV and HTLV-III are renamed HIV. The image is a transmission electron micrograph of the human immunodeficiency virus (shown in the larger cells). It was taken in 1983 and is one of the first photos of the virus.

In the midst of swirling and conflicting opinions, O’Donnell became determined to help put the field of human nutrition on a firmer scientific foundation. “The idea wasn’t resoundingly endorsed at first,” O’Donnell recalled. However, he persisted.

On October 15, 1981, the medical center formed the Center for Human Nutrition. Scott Grundy, MD, PhD, had been recruited as its director by Drs. Mike Brown and Joe Goldstein. The Center was opened

with state funds and an endowed chair from O’Donnell. The medical school committed the space and the equipment. At the time, UT Southwestern was only the second medical school ( behind Columbia) to begin such a center. The Friends of the Center for Human Nutrition, led by Vin Prothro, a former Texas Instruments executive and technology leader, would later raise an additional $2 million. The focus of the research was on “important medical problems in our society” — especially arteriosclerosis, cholesterol, diabetes, obesity, stroke and hypertension. “There were a lot of misconceptions on the part of the public,” Grundy recalled. “My research emphasis before I came to Southwestern was focused on cholesterol. Considering the work underway here at the time, I guess I was a natural fit,” Grundy added. As Brown and Goldstein continued their research, their work predicted the kind of drug that would lower cholesterol levels. Though Merck held the first statin drug patent, its scientists were not convinced of its efficacy. Ultimately, one of the first clinical trials on statins was done at UT Southwestern. “We were able to show how effective they really were,” Grundy said. It is particularly noteworthy that the groundbreaking work of Brown and Goldstein was done while they were members of the Department of Medicine and fully active in patient care, ward rounds and student teaching.



”Obstacles are what you see when you take your eye off the goal. I resolved

not to take my eye off the goal.” Peter O’Donnell

In the 1980s, Helen Hobbs, MD, was Chief

Resident at Parkland Memorial Hospital.

Donald Seldin, MD, then Chairman of

Internal Medicine, persuaded her to make

the transition from full-time clinician to

physician-scientist and urged her to train

with Drs. Brown and Goldstein.

Beginning in 1983, Hobbs spent four

years as a postdoctoral research fellow in

their laboratory before joining the

UT Southwestern faculty.

“Don Seldin single-handedly changed

the course of my career, and Drs. Brown

and Goldstein provided a tough, rigorous

and yet supportive environment in which to

train as a scientist,” Hobbs said.

Dr. Hobbs is now considered one

of the world's foremost geneticists in the

areas of cholesterol metabolism and

cardiovascular disease.

Donald Seldin, MD, and Helen Hobbs, MD

Scott Grundy, MD, PhD


14

y 1981, it was clear to many members of the medical school that in addition to a teaching hospital, the country’s top academic clinicians sought a referral hospital where they could admit patients and offer a wider breadth of specialized medical treatments. Within Dallas, it was beginning to be seen as an economic priority as well. In Houston, the Texas Medical Center had become an economic engine and home to the largest concentration of medical facilities in the world. World-class physicians such as cardiologists Michael E. DeBakey and Denton A. Cooley had attracted international attention. Both UT Southwestern and the city of Dallas were at a competitive disadvantage. The UT Board of Regents agreed to support an outpatient facility — where doctors could provide for their patients’ more basic health care needs — but supporting a new hospital was seen as too great a financial risk to consider. After garnering financial support from the UT System, the medical school broke ground on what would become the James W. Aston Ambulatory Care Center. The seven-story outpatient facility opened in 1984. But planning, constructing and profitably operating a new hospital without the benefit of local or state tax support, or funding from the UT System, presented a daunting challenge. One December evening in 1981, a pediatrician at Children’s Medical Center, Robert Kramer,MD, and his wife were dining with their friends, Bruce and Lynn Lipshy. Lipshy asked Kramer

what he thought Dallas needed most, providing Kramer an opportunity to explain the benefits of a referral hospital. “Let’s do it !” was Lipshy’s immediate response. Lipshy later contacted Donald Zale, who was equally enthusiastic. Owing to Lipshy and Zale’s enthusiasm, a series of conversations with Sprague, Neaves and Wildenthal began, and the realities of a referral hospital were discussed in detail. The Zale Foundation funded a feasibility study and, along with a sizable commitment

from the Zale Corporation, committed nearly $10 million to the project. Though additional monies would be needed, Zale and Lipshy’s commitment had attracted the attention of the philanthropic community, including Ralph Rogers.

”Our institution [was] the only one of the top 20 medical

schools in the nationthat [did ] not have such a hospital.

It was something we wanted and expressed a need for...but I

honestly didn’t know how it was going to come about.”

Charles C. Sprague, MDPresident of the Medical Center

The Zale brothers, Morris and William, started Zale Jewelers with a single store in Wichita Falls, Texas, in 1924. When Morris Zale retired as President in 1957, his brother-in-law, Ben Lipshy, succeeded him. In the 1970s, Lipshy’s son, Bruce, became Vice President. When Morris retired as Chairman in 1970, his son, Donald Zale, rose to the position of President and CEO. From 1970 to 1980 company sales tripled to over $1 billion. Don worked for the company for 35 years.

Don Zale and Bruce Lipshy

B



Charles Sprague, MD, and Kern Wildenthal, MD, PhD,then Dean of the Medical School, present Peter O’Donnell with a $23 million plan to grow faculty endowment. O’Donnell contributes a significant matching grant to fund the plan.____________University Medical Center, a nonprofit corporation dedicated to building a university-related teaching and research hospital, is formed.____________

____________Stormie Jones, after receiving the world’s first heart/liver transplant in February, is admitted to the medical school’s General Clinical Research Center for studies on cholesterol metabolism.

The James W. Aston Ambulatory Care Building becomes the first major on-campus outpatient facility where

faculty physicians can see private patients. The building is named in honor of the late James W. Aston, longtime

Chairman of Southwestern Medical Foundation.

1 9 8 4


Kenneth Altshuler, MDRon J. Anderson, MD

David W. Bilheimer, MDF. Gary Cunningham, MD

William J. Fry, MDRobert J. Kramer, MD

James P. McCulley, MDWilliam L. Meyerhoff, MD, PhDP. O’B. Montgomery, Jr., MD

Vert Mooney, MDAlan K. Pierce, MD

Roger N. Rosenberg, MD

Duke Samson, MDDonald W. Seldin, MD

Vernie A. Stembridge, MDRobert V. Walker, DDSJames Willerson, MD

Paul M. Bass*Gene H. Bishop

Nancy G. BrinkerWilliam E. Collins

William E. Cooper*Robert W. Decherd

Ruben EsquivelLee Fikes

David G. FoxGerald W. Fronterhouse

John P. Harbin

William R. HawnJohn J. KickhamBarron U. Kidd

Margaret McDermottL. William McNutt, Jr.

Harvey R. MitchellPeter O’Donnell, Jr.Patricia PattersonJohn G. Penson

C. Vincent Prothro*David W. Quinn*

Michael F. Romaine, PhDFrank M. Ryburn, Jr.

Ruth C. SharpCharles M. Solomon

Richard C. StraussJere W. Thompson

Terry M. WilsonWarren G. Woodward

Lew D. Zale

The governing body of Zale Lipshy University Hospital embodied the resolve of dozens of business and civic leaders. They served to ensure the future growth

and excellence of the medical school by continuing to attract the best faculty and outstanding students, improving health care services for the community

and providing international recognition for Dallas as a major medical center.

* Executive Committee** Deceased

16

U N I V E R S I T Y H O S P I T A L B O A R D

C H A I R M A N Donald Zale*

F O U N D I N G C O - C H A I R M E N

Ben Lipshy**Ralph B. Rogers

V I C E C H A I R M E N

Charles G. Cullum* Bruce A. Lipshy*

Charles C. Sprague, MD*

P R E S I D E N T A N D C E O

Ronald F. Garvey, MD

M E D I C A L A D V I S O R Y B O A R D

C H A I R M A N

Kern Wildenthal, MD, PhD

V I C E C H A I R M A N

John W. Burnside, MD


It was determined that the medical school would provide the medical staff, Parkland would provide support services and a new independent entity, University Medical Center (UMC), would take on the financial responsibility. “Looking back, it is very clear that financing would not have come about without Ralph Rogers,” Sprague said. By 1987, as a result of Rogers’ leadership, a unique bond structure was created that led to UMC completing, in March, a $40 million tax-exempt bond offering. Two months later, on June 23, stakeholders broke ground on the hospital. Meanwhile, the Foundation helped set in motion private funds to effect the payback of the bond issue. In 1987, $23 million was raised and $15 million in additional support was underway.

arold Simmons had a form of arthritis that affected his spine and shoulder. The middle son of rural Texas schoolteachers, Simmons was a self-made billionaire. At age 29, he borrowed money to buy a small drugstore and within a decade had built a statewide drugstore chain, which he sold to the Eckerd Corporation in 1973 for more than $50 million. Following the sale, Simmons prospered as an intuitive investor and creative financier. Simmons’ arthritis specialist was in private practice at St. Paul. Appreciative of the care he’d received, Simmons offered to fund research that might help others. His doctor redirected Simmons’ interest to UT Southwestern and Morris Ziff, MD, who was leading one of the most advanced arthritis research programs in the country. In April 1983, Harold Simmons pledged $7.5 million to establish the Harold C. Simmons

Arthritis Research Center. At the time, it was the largest gift the medical school had ever received — and the start of what would become a remarkable legacy of giving. That same year, Seldin convinced UT Southwestern graduate Robert Haley, MD, to return to Dallas to found the Division of Epidemiology and Preventive Medicine. Epidemiologists study the relationship between medical conditions and their causes by collecting and analyzing data about public health and the behavior of disease. By determining how and why diseases and illnesses occur, epidemiologists are able to help prevent their spread and recurrence. Haley had worked as a resident at Parkland before leaving for Atlanta to work at the CDC, where he produced a pioneering, 10-year study on the control of hospital-acquired infections. His ideas were implemented by the CDC and helped set the standards for hospitals across the country.


Harold Simmons’ remarkable legacy of giving to the medical center began in 1983.

Morris Ziff, MD, was recruited

from New York University, where

he had established himself as a

distinguished rheumatologist.

Don Seldin, MD, persuaded Ziff

to come to the medical school,

where he grew a program

that became among the best

in the country – accelerated by

Harold Simmons’ generosity.

H

n 1984, the medical center looked to strengthen its molecular biology expertise, especially in the area of gene cloning, because the process had become a critically important component of biomedical research. The medical school was on the hunt for a Chairman of the Department of Biochemistry, which took Joe Goldstein, MD, to Cold Spring Harbor Laboratories in Long Island, New York

— a place Mike Brown, MD, once described as being to biology “what Athens was to philosophy.” There, Goldstein met with Joseph Sambrook, PhD. Sambrook was a British molecular virologist, internationally known for his work with the genetics of DNA tumor viruses and how they integrate their DNA into a host cell. He had been personally responsible for many of the advances in molecular biology technique and had co-authored the definitive manual on gene cloning. In short, Sambrook was exactly who the medical school needed. While there was little doubt that Sambrook could propel UT Southwestern to the leading edge of molecular biology, few thought he would leave the academic environment offered by Cold Spring Harbor. Sambrook had been personally hired as assistant director there by James Watson, MD, the co-discoverer

of the structure of DNA, and was the logical choice to succeed him. UT Southwestern invited Sambrook to spend time on campus beginning in September 1984. During his time in Dallas, he witnessed the level of community support given to the molecular biology department through a significant, anonymous gift donated through Southwestern Medical Foundation. It made an impression. “The standard of science here is very high,” Sambrook noted, “and the people have a great desire to have the place be number one.” He accepted the position as Chairman of the Department of Biochemistry on August 1, 1985.

t was several months earlier in 1985 that Ralph Rogers went to call on a good friend,H. Ross Perot. Perot had consistently expressed interest in supporting “world-class” institutions, and in the previous six years, six UT Southwestern faculty members had been elected to the National Academy of Sciences (NAS) — a prestigious achievement by any measure. But Perot declined Rogers’ request, saying, “Perception is more important than reality”—suggesting that the medical center was not widely perceived as world-class. As it turnes out, Perot was simply tempting fate.


18

Joseph Sambrook, PhD, was world renowned

for his studies of viruses and the molecular

biology of normal and cancerous cells. His

work effectively changed the ways in which

scientists approach the cellular development

of many forms of human cancer. Sambrook

was often described by his peers as brilliant,

feisty, driven and highly competitive.

I

I

“It changed everything.” Peter O’Donnell


20

through their discoveries, [Dr. Brown and

Dr. Goldstein] revolutionized our knowledge about the regulation

of cholesterol metabolism and the treatment of diseases caused

by abnormally elevated cholesterol levels in the blood.”

The Nobel Committee, Stockholm

i don’t believe that the work that Joe and I have done

could have been done at any other institution.”

Michael S. Brown, MDNobel Laureate

“

“

NOS.1&2

it isn’t often in the course of an institution’s history that a single year stands out so clearly, but such was the 1985—1986 academic year for UT Southwestern. On October 14, 1985, it was announced that Drs. Joseph L. Goldstein and Michael S. Brown had won the Nobel Prize in Physiology or Medicine ”for their discoveries concerning the regulation of cholesterol metabolism.” Never before had a Nobel Prize in Physiology or Medicine been awarded forresearch done exclusively within the state of Texas. Brown and Goldstein found that “human cells have low-density lipoprotein (LDL) receptors that remove cholesterolfrom the blood” and that when LDL receptors are not present in sufficient numbers, individuals become at risk for cholesterol-related diseases. It was a pioneering discovery that would lead to the development of statins, which help regulate cholesterol, improve the quality of life for millions of people, and save lives. The Nobel Prize, wrote Harriet Zuckerman in her book Scientific Elite, is the “gold standard by which all other scientific awards are judged…[the] universal and instantly understood metaphor of supreme achievement.” When Brown and Goldstein received their Nobel awards in Stockholm on December 10, 1985, it was a triumph not only for their landmark research into cholesterol metabolism but for UT Southwestern and the Dallas community, which had nurtured their talent, supported their work and maintained their loyalty in the face of highly attractive offers from other prestigious institutions. In scientific circles, the question was asked: What was it about UT Southwestern that encouraged the growth and development of these two assistant professors?

The answer is found in the DNA that makes up the medical school: an insistence from Dr. Cary when the school was founded — that medical and scientific excellence be intertwined with a unique culture of collaboration. Brown and Goldstein did more than help inspire the commercial development of a new category of lifesaving drugs — they electrified the

imaginations of medical researchers around the world. The scientific foundation of their work was the discovery that cells have surface receptors that trap cholesterol-carrying molecules, which are then internalized for cellular use. When Brown and Goldstein started out, the existence of cell receptors was known — but what those receptors did, how they worked or how common they were was unknown. The discovery that receptors played a vital role in the regulation of cholesterol in the



Drs. Brown and Goldstein celebrate with colleagues at the UT Health Science Center after the announcement was made that the two had been awarded the 1985 Nobel Prize in Physiology or Medicine.

Since 1901, the Nobel Prizes in Physics, Chemistry, Physiology or Medicine, and Literature and the Prize in Economic Sciences have been awarded in Stockholm.

bloodstream was a quantum scientific leap. Suddenly, it seemed possible that receptors might be unwitting doormen allowing disease to enter the cell — a kind of microscopic Trojan horse. It was an idea that could be applied to many metabolic processes, and it illuminated a new realm of discovery at life's most basic level.

s soon as he heard the announcement, Rogers called Perot. Getting on the line, Perot laughed: “When I walked into the office this morning, I told all of my associates that I would be hearing from Ralph today. I said that this was going to cost me.” Before making a donation, Perot did something that proved farsighted. Not thinking it was right that Dallas could celebrate a championship football team that had brought the city great pride yet have no plans to honor two Nobel Prize winners, he sponsored a dinner, using his clout to help attract some 300 community leaders. “Perot Lauds Two Nobel Laureates,” read the headline on the front of The Dallas Morning News Metropolitan section on January 10, 1986. The feature story explained that business and civil leaders had gathered “to hear Perot and other speakers…praise the individuals and the institution that brought Texas its first homegrown Nobel Prize.” The joyous celebration

would mark the beginning of Dallas’ ongoing commitment on the part of many in the city to support biomedical education and research. Over the next few years Perot became more involved in the medical school. He gathered input from Goldstein, Brown and others. They explained that the best basic science investigators build their laboratories with both postdoctoral fellows and exceptional students to assist them. While the school had begun a small MD/PhD program in 1978 and was able to offer to participants some financial assistance, funding fell far short of the need. Perot recognized the opportunity and provided a $20 million, 10-year grant, which enabled UT Southwestern to create the single largest and most competitive Medical Scientist Training Program (MSTP) in the country. At the time, it was thought to be the only program that would enable a student to become an MD/PhD with little or no debt. Perot called it “an investment in people and in intellect that will bring enormous

rewards in the years to come. These funds will help train young scientists who might well make the important medical breakthroughs of the future.” He added: “UT Southwestern is the only institution in this part of the country that has the capability of becoming the best of its kind in the world in the next few years.” Perot’s support was more than financial. He personally attended MSTP functions and spoke to potential candidates. And his contribution was not only critical to UT Southwestern but helped a nation keep among its highest priorities the process of actively identifying, encouraging and financially supporting the next generation of its most brilliant medical researchers.


22

After gathering input from Brown and Goldstein, Ross Perot announced that he would provide the funding to create the largest Medical Scientist Training Program (MSTP) in the country.

A



Michael S. Brown, MD, and Joseph L. Goldstein, MD, are announced winners of the Nobel Prize in Physiology or Medicine. ____________Medical school personnel treat victims of Delta Air Lines Flight 191, which crashed near DFW Airport.____________Joseph Sambrook, PhD, becomes Chairman of the Department of Biochemistry.____________

____________Southwestern Medical Foundation pledges $1 million to a new private, nonprofit referral hospital proposed by University Medical Center once certain conditions are met. The gift is earmarked for the purchase of equipment used for research, teaching and patient care.

By the mid-1980s, the campus has grown into a sprawling biomedical complex, housing one of the finest scientific

faculties in the nation who are engaged in the training of new physicians, in research that often is of worldwide

importance, and in the development of new health care techniques that will improve the quality of medicine.

1 9 8 5


Continuing a longstanding legacy of giving, the Hoblitzelle Foundation makes seven gifts totaling just under $2.1 million to Southwestern Medical Foundation in support of the medical center and health care across the state. The Hoblitzelle Foundation’sannual giving has proved foundational and transformative since the school’s founding in 1943.____________Howard Hughes Medical Institute (HHMI) announces its intent to establish a major research unit at the medical school — a five-year, $20 million commitment to develop a center for molecular biomedical research. Later in the year, HHMI launches a $60 million researchprogram devoted to the science of structural biophysics. UT Southwestern is one of only six of its member institutions selected for the task.____________

____________The Charles Cameron Sprague Distinguished Chair in Biomedical Science is established as a permanent endowment upon reaching its $500,000 goal. A few years later, the endowment reaches $1 million.____________Bruce Beutler, MD, joins the Howard Hughes Medical Institute (HHMI) at UT Southwestern, returning to the medical school where he completed his residency.

24

In the early 1980s, the John A. Hartford

Foundation in New York was

interested in making grants aimed at

accelerating university-originated

biomedical discoveries to benefit

patients. The Hartford Foundation had

a solid reputation for providing grants

for innovative public health programs

and specialized clinical research.

It took proposals from 13 medical

centers, including Harvard, Johns

Hopkins and UT Southwestern.

The UT Southwestern proposal

was the joint product of the

medical center and a mayor’s task

force to stimulate development of a

biotechnology industry in Dallas.

In early 1985, Hartford announced

that UT Southwestern would receive

the five-year, $3 million award – the

largest in the foundation’s history – to

create a venture capital pool to fund

innovative biotechnology projects.

The effort is formally established

in March 1986 as Dallas Biomedical

Corporation – a private venture

between UT Southwestern and inves-

tors. It is the first organization

of its kind in the country and draws

international attention.

Its unique funding contribution to

research projects at UT Southwestern

is supported by the interest

earned on $12.5 million in escrowed

investments by private investors. The

medical center contributes to the

funding of research projects from its

Hartford grant.

Between 1986 and 1990, Dallas

Biomedical funds 30 research projects

it feels have commercial promise.

After a reorganization, the company

focuses its efforts on a new cancer

therapy. However, the company is

faced with raising as much as $40

million to be able to take the therapy

through early-stage clinical studies.

When that proves too much

of a risk for investors, the developed

technologies become part of the

UT Southwestern intellectual property

portfolio and are offered to

industry under traditional licensing

arrangements.

Vin Prothro led the effort to raise private venture capital to launch the Dallas Biomedical Corporation.

1 9 8 6

n February 1986, the Howard Hughes Medical Institute (HHMI) announced it was establishing a major research unit at the school — a five-year, $20 million commitment to develop a center for molecular biomedical research. UT Southwestern was one of only 12 major university medical centers in the country to be chosen by HHMI and would be the site of one of its largest research centers.

The Hughes designation catapulted the medical center to the forefront of molecular biomedical excellence. At the time, it was the largest infusion of private funds from a single source in the institution’s 43-year history. The timing of the announcement could not have been better. Joe Sambrook, PhD, well understood its recruitment value and, armed with fully funded Hughes “Investigatorships,” set out to aggressively build his department. On a personal level the timing also proved auspicious because renowned molecular biologist Mary-Jane Gething, PhD, a researcher at Cold Spring Harbor Laboratory and Sambrook’s wife, would soon become one of the school’s first Howard Hughes Investigators. Her memories encapsulate the school’s unique culture: “The whole medical school was special. Many medical schools…[had] deep divisions between the basic researchers and the clinicians. But in Dallas…there’s a guy called Don Seldin who…had insisted that his clinicians have a research focus. So there was this amazing synergy there between the clinicians and the basic scientists.”

n May 1986, Wildenthal put the remarkable academic year into perspective in a report made to the Foundation: “As with most worthwhile endeavors the dividends being realized now are more the product of wise investment and decisions made over the past four decades....Those of us who are in a position to enjoy today’s success owe an immeasurable debt to our predecessors for making these successes possible.” It was an acknowledgment of the visionary leadership provided by Cary, Seldinand Sprague, among others, as well as the work of recent Foundation leaders such as George MacGregor, James Aston and James Keay.



Howard Hughes (seen here with his new Boeing 100A,a civilian version of the Army’s P-12B pursuit aircraft, in Inglewood, California, in the 1940s) founded the HHMI in 1953.

Most remember Howard Hughes as an eccentric billionaire who spent his last years in isolation, but Hughes was a man of extraordinary intellect and diverse talents: an investor, aviator, aerospace engineer, inventor and filmmaker. He acquired and expanded Trans World Airlines ( which later merged with American Airlines) and

developed Hughes Aircraft Company. But Hughes’ enduring legacy is the Howard Hughes Medical Institute. His vision of scientific philanthropy was to commit monies that would probe “the genesis of life itself.” Hughes was born in Humble, Texas, and is buried in Houston, Texas.

I

I

s a final exclamation point to the academic year, in May 1986 the HHMI launched a $60 million research program devoted to the science of structural biophysics. UT Southwestern was one of only six of its member institutions selected for the task. The goal of the research was to unlock the mysteries of protein structure and function. There are tens of thousands of proteins in the body. Each has a highly specialized biochemical function that is determined by its shape. But accurate visualization of those

proteins was a highly complex, time-consuming process. X-ray crystallography, developed by physicists to determine the precise arrangement of atoms in metallic crystals, was one of the best visualizing tools available. So, with his Howard Hughes Investigatorships in hand, Sambrook went in search of the world’s premier X-ray crystallographers. During his search, exceptional researchers outside the field of X-ray crystallography were identified — including 28-year-old researcher Bruce Beutler, MD, who had done his residency at UT Southwestern a few years earlier. Beutler joined HHMI at UT Southwestern later that year and set up his lab. His interest was in developing a means to block a cellular activity called “tumor necrosis factor” (TNF), which could prove useful in reducing chronic inflammation. Beutler’s lab patented a unique protein, which was ultimately acquired by Amgen. Today, the molecule his team invented is marketed as Enbrel, an effective treatment for rheumatoid arthritis and other inflammatory diseases.

n August 31, 1986, Charles Sprague, MD, stepped down as President of The University of Texas Health Science Center. Sprague had guided its growth from a small but promising medical school into a leading comprehensive medical and life sciences center. Upon his retirement, he was named President Emeritus of the medical center and joined Southwestern Medical Foundation, becoming President in 1987 and Chairman of the Board and Chief Executive Officer in 1988. During Sprague’s tenure as President, the medical center’s annual budget had grown from $10 million to $183 million, sustained in large part by ever-increasing appropriations from federal and state funding in support of medical education and research. Throughout the first half of the 1980s, funding had grown steadily, and by 1985 state appropriations alone had reached $62.5 million. It seemed that the momentum of the 1985 —1986 academic year would be unstoppable.

Bruce Beutler, MD, graduated

from the University of California,

San Diego, at age 18 in 1976. He

enrolled in medical school at the

University of Chicago, receiving

his MD in 1981. In 1986, he

was invited by Joe Sambrook to

join the Howard Hughes Medical

Institute at UT Southwestern,

where he set up his own lab.


26

During Sprague’s tenure as President, the medical center’s annual budget grew from $10 million to $183 million.

$200 million

$100 million

1972 1986

$183 M

$10 M

A

O



1 9 8 6

”There is no question that the medical center would

not have achieved its success...would not enjoy the

present outstanding physical plant...and would not

have some of its very best faculty residing at the

school had it not been for private support.”

Charles C. Sprague, MD

On August 31, Charles Sprague, MD, steps down as President of The University of Texas Health

Science Center. The next day, Kern Wildenthal, MD, PhD, assumes the presidency.

In the spring of 1986, the medical school comes full circle: Its first graduate retires. In 1944, Ervin Addy, MD, 65, had been the first of 61 graduates to walk across the stage and receive his medical degree from the fledgling medical school made of plywood and big dreams. Now, near the same time Addy retires, the Howard Hughes Medical Institute announces its plan to spend at least $20 million to set up a major biomedical science facility, establishing labs on two floors of the Cecil H. and Ida Green Science building to accommodate up to 25 scientists. It’s a remarkable contrast that demonstrates just how far the medical school had come in only 42 years.

The first graduation ceremony was held in March 1944 in the Alex W. Spence Junior High School auditorium.

[ CONT. ]


28

The UT System Board of Regents changes the name of the health science center to The University of Texas Southwestern Medical Center at Dallas, ending a long struggle to reincorporate the word “Southwestern” into the name. The effort began in 1970 when Bryan Williams, Associate Dean for Student and Alumni Affairs,

wrote on behalf of medical students who had expressed their deep concern to him: “...we are not only proud of the name ‘Southwestern’ but we are...very appreciative of the part that [Southwestern Medical Foundation] has played in the existence of this medical school.”

1 9 8 7Charles Sprague, MD, joins Southwestern Medical Foundation as President.____________ On March 25, University Medical Center closes on a $40 million, tax-exempt bond offering for Zale Lipshy University Hospital. Ground is broken on June 23. ____________John D. and Catherine T. MacArthur Foundation gives 30 acres of land to UT Southwestern.____________

____________Southwestern Medical Foundation makes a $100,000 donation to be used in setting up a permanent medical and health science exhibit at The Science Place in Fair Park.____________Donald Seldin, MD, announces he will be steppingdown after 35 years as Chairman of Internal Medicine, having built arguably the finest Department ofInternal Medicine in the country. He inspired generations of physician-scientists, creating the intellectual foundation on which UT Southwestern was built.

Ida M. and Cecil Green had a lifelong passion

for learning. Cecil Green co-founded Texas

Instruments in 1951 and had amassed a fortune

by the time he retired in 1975.

The Greens devoted their lives to giving

away the fortune – with over $30 million directed

to UT Southwestern.

Beyond their lifelong and extraordinary

support of the medical center, the couple gave

hundreds of millions of dollars to educational

and medical facilities all over the world.

Believing in a “multiplier factor,” the Greens

felt that by contributing to the training of

scientists, physicians and educators, their gifts

would eventually impact the lives of many

thousands, perhaps even millions, of people.

Ida passed away in 1986 at the age of 83,

following a battle with leukemia.

Ida M. and Cecil Green in front of the Green Research Building.

The Green Research Building was adjacent to the Green Building (which Ida M. and Cecil Green also helped fund) on the South Campus.

FEATURED DEPARTMENTS, LABS AND CENTERS

» Animal Resource Center

» The Center for Human Nutrition

» The Department of Biochemistry

» Divisions of the Department of Internal Medicine including Endocrinology, Rheumatology and Infectious Disease

The Green Research Building



Kern Wildenthal, MD, PhD, joined the UT Southwestern faculty as an Assistant Professor of Medicine and Physiology in 1970, becoming an Associate Professor in 1971 and full Professor in 1975. From 1976 to 1980, he served as Dean of the Graduate School, and from 1980 to 1986 he was Dean of the Medical School.

he day after Sprague retired, Wildenthal took the helm as only the second president of the medical center — a position he would hold for the next 22 years. Wildenthal was the unanimous choice of the UT System Board of Regents and an internationally recognized research scientist in the field of cardiac physiology, having authored more than 120 scientific papers in basic research and clinical cardiology as well as numerous articles on health and education policy issues. During his tenure as Dean of the Medical School, eight of its professors were named to the National Academy of Sciences (NAS). But almost overnight, the price of oil plummeted. The Texas real estate and banking markets collapsed, and the state economy was thrown into a deep recession. Wildenthal was only a few weeks into his Presidency when he was informed that state supportfor the medical school’s 1986 — 1987 budget would be cut by 14%. “With this news came the solemn warning

that the decreased budget level would be perpetuated until further notice,” he recalled. “We were suddenly thrown into a serious financial crisis at a time when we were fundamentally poised to move forward and capitalize on the huge gains made over the past few decades.” UT Southwestern needed to raise millions of dollars. And quickly. Joined by Sprague (now President of the Foundation) and other Foundation members, Wildenthal reached out to members of the community familiar with the medical school for their help— a list that included Harold Simmons, Peter and Edith O’Donnell, Erik Jonsson, Cecil Green and Margaret McDermott. Importantly, efforts were made to engage others less familiar with UT Southwestern, including Nancy Hamon, Charles and Sarah Seay and dozens of other donors, a few of whom preferred their generosity be paired with anonymity.

In 1986, Saudi Arabia ramped up output, which sparked a 60% plunge in the price of oil, sending it just above $10 a barrel. The drop created an oil bust and banking crisis that drove the Texas economy into recession. State unemployment would reach 9.3%. Between 1986 and 1990, more than 700 Texas banks and thrifts would fail. As a result, beginning in 1986, state funding to UT Southwestern is immediately cut by 14%.

T


30

meanwhile, Sambrook was determined to recruit Johann Deisenhofer, PhD, who worked at the Max Planck Institute for Biochemistry in Martinsried, a small town near Munich. Together with Hartmut Michel and Robert Huber, Deisenhofer studied a protein complex found in photosynthetic bacteria called a photosynthetic reaction center. In a collaboration that started in 1982, the three scientists used X-ray crystallographyto determine the precise structure of this membrane-bound protein atom by atom —more than 10,000 atoms in total. The task was largely finished in 1985, and the reaction center represented the largest and most complex structure ever solved by X-ray crystallography up to that time. The structural determination helped explain the detailed mechanism of the conversion of light energy into chemical energy in photosynthesis, a biological process upon which almost all life on our planet depends. But their work had implications in other fields far outside the area of photosynthesis research. Many other critical biological functions are associated with membrane-bound proteins, such as the transport of nutrients into cells, hormone action and nerve impulses. Word of Deisenhofer and his team’s remarkable success had spread throughout the world scientific community. He’d received numerous invitations to report his results in scientific meetings, seminars, even TV shows. “I received a formal letter from Joe Sambrook (whom I had never heard of ) asking

whether I might be interested in a faculty position,” Deisenhofer said. “I knew absolutely nothing about the place…but a postdoctoral fellow in our research group in Munich had completed his PhD at Baylor College of Medicine in Houstonand spoke highly of UT Southwestern.” Deisenhofer ended up visiting the campus twice. He was impressed by the breadth and depth of the school’s basic sciences department and the spirit of collaboration that existed between it and the clinical departments, and he recognized the benefits of being a Howard Hughes Investigator. During both visits, Sambrook fortuitously asked Kirsten

Fischer-Lindahl, a Professor of Microbiology and Biochemistry and a Hughes Investigator, to show Deisenhofer around Dallas. “Almost immediately after I met her, I fell in love,” Deisenhofer recalled. In March 1988, Deisenhofer moved to Dallas to become a Professor of Biochemistry at UT Southwestern and Investigator at the Howard Hughes Medical Institute. In December, Deisenhofer, Michel and Huber received the 1988 Nobel Prize in Chemistry for their work. Fischer-Lindahl and Deisenhofer were married in 1989.

Johann Deisenhofer raising a glass at the Nobel Awards dinner in Stockholm.

the work on the photosynthetic reaction center changed my life

in many ways. It was a special privilege to belong to the very small group

of people who saw the structural model of this molecule grow on the

screen of a computer workstation, and it is hard to describe the excitement

I felt during this period of the work. The wide recognition of our work also

opened the possibility for me to move to a new place, and to build a

research group of my own. The best of several opportunities was an offer

from The University of Texas Southwestern Medical Center at Dallas.”

Johann Deisenhofer, PhD Nobel Laureate

7 5 Y E A R S O F V I S I O N : T H E L A S T I N G G I F T7 5 Y E A R S O F V I S I O N : T H E L A S T I N G G I F T


“

NO.3

“People would always see me orMike or both of us and say, ‘Oh, you’re

the guy who won the Peace Prize.’We used to say, ‘No,we did this and that.’

Now, we just say, ‘Yeah.’” Joseph L. Goldstein, MD

“Very frequently, people will call me Joe,and they’re always embarrassed,

and I say: 'Don’t be embarrassed. My wifemakes the same mistake.’”

Michael S. Brown, MD


32

After winning the Nobel Prize, Drs. Brown and Goldstein were offered top positions at many of the most prestigious medical institutions across the country. As partners, they made a conscious decision not to seek the limelight but to continue working together, doing the things they loved — staying close to the science and to the students. They attracted funding, tirelessly recruited new talent and contributed thinking that hadan extraordinary impact on the medical center. To many observers, it was remarkable how easily they shook off winning the Nobel Prize and went on their way. Yet they were, in fact, rock stars of medical science — celebrities who wore the mantle of their achievements with grace while garnering increasing recognition from the scientific and lay communities.

Michael Brown, MD, and Joe Goldstein, MD

n 1986, Scott Grundy, MD, PhD, working with researchers in California, was comparing the effects of different types of fats on cholesterol levels. In the Mediterranean region of the world, people had eaten comparatively large amounts of olive oil — a monounsaturated fat — for centuries. And yet studies had shown that in those populations cholesterol and heart disease were quite low. At the time, it was believed that polyunsaturated fat — the fat found in corn and safflower oils — was far healthier. “Our studies proved that monounsaturated fat lowered cholesterol as much as polyunsaturated fat did when you substituted it for saturated fats,” Grundy said. “Furthermore, monounsaturated fats are synthesized normally by the body and less likely to have some of the side effects that have been postulated to occur with polyunsaturated fats.” The news generated tremendous interest worldwide, and millions of people began adding

olive oil to their everyday diet. In September 1987, the first statin drug, lovastatin, was approved by the FDA and released for marketing as Mevacor (Merck). Many others would follow. Over the next 15 years, Brown and Goldstein, Grundy, and a host of leading investigators at UT Southwestern continued to conduct research on various statin formulations. Their results, combined with

that of researchers around the world, confirmed the safety and effectiveness of statins in preventing heart disease in people with high cholesterol.

y the late 1980s, reducing the amount of fat in one’s diet had been identified as one of the most important changes needed to improve the nation’s health. Medical, scientific, federal and international agencies spread the word that saturated

fats cause heart disease. A concerted national effort to reduce saturated fat began. Certain foods, like red meat, became particularly associated

with heart disease. In 1988, however, Grundy surprised the nation’s nutritionists with

his discovery that stearic acid, a saturated fat — “the bad kind” — did not raise total cholesterol. Grundy proved that once stearic acid got into the body,

the vast majority of it was quickly converted to monounsaturated fat: “the good kind.” The announcement bordered on heresy for many nutritionists and generated headlines across the country with the news that foods high in stearic acid, like beef fat and cocoa butter, were not as detrimental to one’s health as experts had long assumed.



“Statins are oneof the major accomplishments

in medicine in the pastthree decades. They will save

millions of lives in theU.S. and around the world.”

Scott Grundy, MD, PhDDirector The Center for Human Nutrition

Olive oil – a monounsaturated fat – is a key component of the Mediterranean diet.

I

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ith the tremendous successes of the 1980s, it was becoming apparent to Wildenthal and Neaves that at the rate the medical center was growing, it would soon be landlocked. For many years, a tract of land covering roughly 65 acres just north of the medical school lay dormant. The open space belonged to the Chicago-based John D. and Catherine T. MacArthur Foundation — one of the nation’s largest independent foundations. Initially, UT Southwestern had no interest in the land. But the growing school’s attempts to acquire property across from the main campus on Harry Hines Boulevard failed, and federal regulations prevented any disturbance of eight, heavily treed acres on the main campus that were home to a sizable population of snowy egrets. On behalf of UT Southwestern, Neaves, Vin Prothro and Philip O’Bryan Montgomery, III, agreed to work with the MacArthur Foundation to explore acquiring the land as a philanthropic gift. After months of preparation, a formal request was submitted. While the request was acknowledged to be a worthy cause, it was rejected because it fell outside of the core mission of causes the MacArthur Foundation supported. Rather than accept the rejection, a team that included Wildenthal, Montgomery, Prothro and O’Donnell reimagined its approach. A new proposal asked for a donation of 30 acres, requested the rights to purchase another parcel of land over time — and put forward a convincing argument that as the land was developed, the portion the MacArthur Foundation

retained would rise dramatically in value. The proposal was approved with certain conditions, and near the end of 1987 UT Southwestern officially acquired the first 30 acres of North Campus land. With the land secured, a master plan for the North Campus was drawn up: the result of a 10-month study funded in part by a grant from Southwestern Medical Foundation. The plan called for the construction of more than 2.5 million square feet of facilities over a period of 20 years. Just months later, in 1988, Harold Simmons made an unprecedented $41 million commitment to the medical center to begin to develop what was called the North

Campus. At the time, it was the largest philanthropic gift in Dallas history and ranked as one of the largest donations ever made for medical research in the U.S. The gift included the funds to complete the first research building (the Simmons Biomedical Research Building), to provide additional funding for arthritis research and cancer research, to help establish the


34

In 1988, the Heart Transplant Program was initiated at UT Southwestern. W. Steves Ring, MD, Professor of Cardiothoracic Surgery, performed the first transplant on noted author and Texas historian A. C. Greene. Faced with incurable cardiomyop-athy, in June 1988 Greene underwent a heart transplant and two years later published Taking Heart, in which he described the experience of receiving the heart of a 31-year-old woman (who had died from a brain tumor)and his gratitude and joy at getting a second chance at life.

Philanthropist C. Vincent (“Vin”) Prothro, UT Southwestern Professor William Neaves, PhD, and businessman Philip O’Bryan Montgomery, III, were instrumental in facilitating the donation by the MacArthur Foundation on which the North Campus would be located.

W


Johann Deisenhofer, PhD, is awarded the Nobel Prize in Chemistry.____________Harold C. Simmons commits $41 million to UT Southwestern for cancer and arthritis research.____________The Perot Foundation commits $20 million to UT Southwestern to fund the Medical Scientist Training Program (MSTP).____________Daniel Foster, MD, becomes Chair of the Department of Internal Medicine, succeeding Donald Seldin, MD.____________

____________

____________ Donald Seldin, MD, is named President of Southwestern Medical Foundation, succeeding Charles Sprague, MD, who becomes Chairman and Chief Executive Officer. James W. Aston, who served as President for eight years and Chairman for seven years, joins George L. MacGregor as Chairman Emeritus. The Foundation also honors four decades of service by Evelyn Whitman, establishingthe Evelyn M. Whitman Scholarship Fund.____________A $5 million grant from the National Institute on Aging establishes a center to explore the underlying genetics and biology of memory loss, dementia and aging, giving UT Southwestern the only Alzheimer’s Disease Research Center in the Southwest (at the time).


Researchers from UT Southwestern’s Space Medicine Laboratory take an electrocardiogram while weightless during a NASA 707 flight as it soars on a parabolic curve path. Both Buckey and Gaffney later fly as NASA astronauts.

From left, a NASA technician, Lynda Lane, Jay Buckey, MD ( horizontal) and Drew Gaffney, MD

Oscar-winning actress Greer Garson Fogelson donates $1.5 million to the Foundation to endow a chair honoring Paul C. Peters, MD, who had cared for her husband, oilman E.E. “Buddy” Fogelson. Peters was internationally recognized for his leadership in urological surgery and, in 1964, headed the team that performed the first kidney transplant in Texas.

Greer Garson Fogelson and E.E. “Buddy” Fogelson

[ UT Southwestern] has become a distinguished institution with a national reputation of significance. This is all the more commendable in view of the fact that the school was founded in rather humble surroundings only 45 years ago. In this short time, the medical school has developed an enviable national reputation for teaching, scientific inquiry and patient care.”The Liaison Committee of Medical EducationThe official accrediting body for educational programs leading to the MD degree in the United States.

1 9 8 8

“


36

An $8.3 million,10-year commitment is made to establish theHarry S. Moss Heart Trust. The medical center was first selected as a recipient of Moss Trust funds in the early 1970s when an original commitment established the Harry S. Moss Heart Center.____________

Southwestern Medical Foundation celebrates its golden anniversary.____________Paul Bass, Jr., is elected as a Foundation Trustee after histerm as Chairman, Board of Managers of Parkland, ends in January. “It’s a great compliment,” he says. “I think the medical school is the greatest asset of the city of Dallas.”____________A 20-year master plan calls for the construction of six research towers on the North Campus. The 10-month study, funded in part by a grant from Southwestern Medical Foundation, calls for the construction of more than 2.5 million square feet of facilities.____________

____________ Researchers at UT Southwestern refine a fast-acting drug called tissue plasminogen activator (tPA), which can rapidly dissolve blood clots in patients with ischemic stroke, greatly reducing the risk of mortality or severe disability.____________UT Southwestern establishes the Department of Neurosurgery, which is chaired by Duke Samson, MD, who will later be dubbed by D Magazine as “the most interesting neurosurgeon in the world.”____________John P. Perkins, PhD, becomes Dean of the UT Southwestern Graduate School of Biomedical Sciences, and William B. Neaves, PhD, officially becomes Dean of the Medical School — the unanimous choice of a 16-member search committee.____________The Foundation receives its first distribution from the Shannon estate, estimated at almost $4 million. Hall Shannon, MD, was one of the original founders of the Foundation.____________Zale Lipshy University Hospital opens, providing greater access to UT Southwestern’s clinical specialists and faculty. “I couldn’t have survived the construction and opening of Zale without Bill Neaves,” recalls Don Zale.

UT Southwestern researchers in mineral metabo-

lism, including the world-renowned Charles Pak,

MD, announce results of clinical trials using a

new treatment to restore spinal bone mass. The

slow release form of sodium fluoride with calcium

citrate — which later becomes known as Citracal TM—

is shown to safely reverse the effects of

osteoporosis by augmenting bone mass.Charles Pak, MD

1 9 8 9

Harold C. Simmons Comprehensive Cancer Center and to endow five Distinguished Chairs named for his four daughters and his wife, Annette. Yet even with the monies in place to cover the construction costs of the first research tower, there remained a critical hurdle to overcome: Being a state institution meant that construction of all new medical school buildings required approval from the Texas Higher Education Coordinating Board. And the deep economic downturn in Texas had resulted in a moratorium on all new construction at state universities. After initial talks, there appeared to be no room for exceptions. In fact, the Board Building Committee recommended disapproval of the construction. Wildenthal took charge, aided by calls from community members with relationships in Austin. He invited Coordinating Board members to learn the details of the MacArthur grant and the implications of Simmons’ generous gift, emphasizing among other things that the fully funded building would serve to attract the country’s best medical researchers. In the weeks prior to the official vote, Wildenthal met individually with members of the Coordinating Board, and on the day of the vote he eloquently addressed the full Board. Instead of voting unanimously to approve the Committee’s recommendation as it had routinely done in the past, the Coordinating Board rendered a split vote and in the process narrowly approved the new construction. Relentless determination in the pursuit of medical excellence was the basis on which the school was built. It would also be the standard on which the future would be built.



On June 5, 1981, the CDC reported a rare

lung infection in five young, previously

healthy gay men in Los Angeles. The men

had other complications; it appeared their

immune systems were failing.

When the first AIDS cases were reported,

no one knew what was causing the

disease or how it was being transmitted,

let alone how to prevent or treat it.

From the outset, AIDS patients were

stigmatized and attracted a high level

of discrimination as the disease was first

linked to gay men and intravenous drug

users. Celebrities like Elizabeth Taylor

came forward to help focus the country

on the human tragedy of the growing

epidemic.

During this period, funding for AIDS

research was not directed to the medical

center. Nevertheless, in 1989 Robert

W. Haley, MD, working with local health

organizations, put together the first

household survey covering relevant issues

such as sexual behavior.

It was highly controversial.

“Our teams went door-to-door and

took blood samples to measure how many

people might already have the latent

infection,” Haley explained.

Follow-up meetings with the Dallas

County Health Department produced the

AIDS Prevention Program. With the results

of the blood test survey in hand, program

members knew where in the community

to focus. They made friends with those

putting themselves at risk and educated

them on the seriousness of the disease

and its prevention.

“It was extremely effective and

attracted funding from the Centers for

Disease Control (CDC) and other sources.

As a result of this initiative, Dallas was the

first major city in the country to turn the

epidemic curve around,” Haley said.

A few years later, it appeared that

federal funding for the AIDS Prevention

Program might be cut. After a series of

meetings that brought The League

of Women Voters, The Women’s Council

of Dallas and The Dallas County Medical

Society together with the medical school,

the AIDS Prevention Program was placed

under the UT Southwestern School of

Health Professions. It was renamed the

Community Prevention and Intervention

Unit (CPIU) and, as a result, was able to

retain its federal grants.

“It has functioned ever since as one of

the finest AIDS prevention programs in

the country with continuous funding from

the CDC,” Haley said.

n January 21, 1989, Southwestern Medical Foundation turned 50. It was a time to reflect on a remarkable legacy of accomplishment.

Later that year, on November 1, Southwestern Medical Foundation and the Hoblitzelle Foundation sponsored a cancer symposium in honor of the Foundation’s 50th anniversary.The event drew many of the world’s most notable leaders in cancer research — a reflection of the respect that UT Southwestern had earned as a leading research institution. “The development of excellence at Southwestern Medical School over the past two decades is now recognized at an international level,” noted Jonathan Uhr, Chairman of the Department of Microbiology. As a result of Harold Simmons’ unprecedented generosity, the medical center could now take steps to establish itself as a leader in oncology research and treatment. Nine days later, at the November 10 dedication ceremonies for the opening of Zale Lipshy University Hospital, Wildenthal praised the city of Dallas for its significant involvement in making it happen. Donald Zale, Chairman of University Hospital at the time, remarked that dedications often mark “a rite of passage from one stage in the life of an institution to another.” And indeed it would be.


38

“…had it not been for the vision and commitment of Dr. Cary and Karl Hoblitzelle there would be no Southwestern

Medical Foundation or University of Texas Southwestern Medical Center, certainly not as we know them today.”

Charles Sprague, MD Chairman of the Foundation

“From the beginning the Foundation has focused itsattention on educating great physicians and meeting the medical

needs of the community, often providing leadership as well as funds for various health care programs.”

George L. MacGregor Chairman Emeritus of the Foundation

“As Southwestern Medical Foundation celebrates its golden anniversary, it does so with the pride of knowing that

the founders’ vision for forging a major medical center in Dallas has become a reality.”

Don Seldin, MD President of the Foundation

O



“Other than the Nobel Prize, this is the honor to which most American scientists aspire.”

Kern Wildenthal, MD, PhD(referring to National Academy of Sciences membership)

UT Southwestern Faculty Elected to the National Academy of Sciences in the 1980s

Michael S. Brown, MD

1980

Joseph L. Goldstein, MD

1980

Jean D. Wilson, MD

1983

Alfred G. Gilman, MD, PhD

1985

Jonathan W. Uhr, MD

1984

Samuel M. McCann, MD

1983

Roger H. Unger, MD

1986

1 9 8 9

8

23

1989 numbers are shown relative to 2015.*National Academy of Sciences

2.4 M$176 M900 31,500

7.7 M$2.3 B2,400 64,700

TotalSq. Ft.

Annual Budget

Full-Time Faculty

NAS*Members

Nobel Laureates

TotalStudents

1989 vs. 2015

[ CONT. ]


40

A collaborative effort between Zale Lipshy and

the Dallas Museum of Art humanized the public

spaces and patient rooms with the glowing colors

and vibrant patterns of museum-quality Asian

textiles. Margaret McDermott made the visionary

suggestion. The acquisition and installation of

approximately 300 textiles was made possible by

a gift from the Eugene McDermott Foundation.Margaret McDermott

The new Zale Lipshy University Hospital provides the medical school a hospital to care for referral patients.

It helps attract and retain strong faculty members from throughout the nation and offers medical students the

opportunity to observe highly specialized medical cases as part of their education.

n August 1990, the medical school successfully recruited Willis Maddrey, MD, as Vice President for Clinical Affairs. One of his responsibilities was to ensure

the success of Zale Lipshy University Hospital, which had opened nine months earlier. Maddrey was an internationally renowned expert on digestive and liver disease and had served as Associate Physician in Chief in the Department of Medicine at Johns Hopkins Hospital. He had directed the liver unit at Johns Hopkins in Baltimore and had been Chairman

of the Department of Medicine at Jefferson Medical College in Philadelphia. The day he arrived in Dallas, only four of the hospital’s six floors were open and no more than a dozen patients occupied beds in Zale Lipshy’s 152-bed facility. To remain viable, a capacity of 100 patients was needed. Parkland had by now been much improved and, as a teaching hospital, it was the focus of much of the faculty’s attention. “No public hospital was more highly regarded in the country,” Maddrey confirmed. “Parkland had the best trauma center in the world. And probably the finest burn unit and obstetrics departments as well." He added, “I was confident that the city could support two parallel hospital services and neither one would be diminished by the other.”

Willis Maddrey, MD, was recruited to ensure the success of the new hospital.



I

BY LEAPS AND BOUNDS

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The new Zale Lipshy was equipped with some of the most advanced medical and diagnostic equipment available.

A patient room at University Hospital.

n 1991, Southwestern Medical Foundation created its most prestigious civic honor, the Community Service Award, given annually to members of the community who provided significant support to the improvement of medical education, research and patient care. The award’s first recipient was James W. Aston, former President and Chairman of Republic Bank, who, like many before him, had long championed the cause of quality health care in Dallas. In the mid-1960s, when Karl Hoblitzelle’s health began to decline during his last years as President of the Foundation, Aston played a key role. During his long history of service to the Foundation, Aston served as Treasurer, Vice President, President, Chairman of the Board and Chairman Emeritus. Southwestern Medical Foundation was just one of a dozen institutions that owed Aston a huge debt of gratitude. Among his many significant accomplishments, his innovative financial strategies are credited for the successful bond campaign that built the Dallas/Fort Worth Airport. When Aston died in 1995, Foundation President Charles Sprague summed up Aston’s contributions: “It would be hard to exaggerate James Aston’s influence on the development of the medical school.”

eanwhile, clinical chairs led by Maddrey were starting to find success growing Zale Lipshy through a select handful of surgical subspecialties that included neurosurgery, otolaryngology (ENT), plastic surgery and ophthalmology. But progress was slow. “Some of the faculty remained unconvinced of the need for a university practice and, for them, seeing private patients was less of a priority than attending at Parkland, teaching and research,” recalls John Rutherford, MD, who joined the

UT Southwestern faculty in 1993 as holder of the Gail Griffiths Hill Chair in Cardiology. “There were a lot of determined people in the community who wanted the hospital to succeed, and they helped us tremendously along the way,” Maddrey noted. The list included Donald Zale ( who served as Chairman of the hospital’s Board of Directors beginning in 1987), Margaret and Eugene McDermott, Cecil and Ida Green, Peter O’Donnell, Erik Jonsson and Ralph Rogers — all of whom, by 1994, had been awarded the Foundation’s coveted Community Service Award.


42

“A sea change in the way the hospital was viewed by the faculty

needed to occur...but we madeit work. And it made a difference.”

Willis Maddrey, MD

James W. Aston was a Dallas banker, civic leader and longtime Foundation Board Member. He joined Republic National Bank as Vice President after World War II and worked under Karl Hoblitzelle, who was Chairman of the bank from 1945 to 1965.

Duke S. Samson, MD, who joined

the UT Southwestern faculty in

1977, was one reason why Zale

Lipshy Hospital grew. His renowned

reputation as a neurosurgeon

attracted patients from across the

Southwest. Samson was named

Chairman of the Division of

Neurosurgery in 1985, which

became a department in 1989.Duke S. Samson, MD

I

M



The Eugene McDermott Foundation and the Biological Humanics Foundation (which McDermott founded) establish a distinguished chair in developmental biology in honor of Philip O’Bryan Montgomery, Jr.____________The Mary Nell and Ralph B. Rogers Magnetic Resonance Center opens its doors. The $4.8 million, 24,000-square-foot building is the first on the medical center’s new 30-acre North Campus site.____________

____________

____________The Foundation receives the final $1.2 million distribution from Mary Lucile Shannon to create the $3.7 million Distinguished Chair in Surgery. Her husband, Hall Shannon, was one of the four co-founders of the Foundation.____________The Mobility Foundation gives $6.5 million to establish the Mobility Foundation Center for Rehabilitation Research.____________Drs. Joel Taurog and Robert Hammer confirmthe creation of genetically altered rats, providing the first animal model for arthritis research.

Bryan Williams, MD, a former UT Southwestern student in 1947, receives

Southwestern Medical Foundation’s prestigious Ho Din Award – the first

time a faculty member has won the award in over 40 years. “I don’t believe

there is an individual in the country who has done a more outstanding

job as a student advocate than Bryan Williams,” says Charles Sprague, MD.

At the same time, the Foundation establishes the Bryan Williams Student

Assistance Fund to help UT Southwestern medical students in their pursuit

of becoming doctors.

Bryan Williams, MD, with students

UT Southwestern announces the endow-

ment of more than 20 new Distinguished

Chairs – the result of a successful

$21 million fundraising campaign. Robert

W. Decherd, Chairman and CEO of

A. H. Belo Corp. (parent company of The Dallas Morning News and WFAA-TV ),

served as Chairman of the leadership

committee.

It was the first organized effort to

seek endowed funds for faculty posi-

tions at the medical school and would

help attract and retain the best medical

minds in the country.

The effort began as a $10.5 million

Southwestern Endowment Challenge,

which was funded by $8.4 million from

The O’Donnell Foundation, $1 million

from Ida and Cecil Green, $1 million from

Southwestern Medical Foundation and

$100,000 from an anonymous donor.

“[ The Chairs ] serve as tangible

symbols of the great progress being

made by this campus and the community

effort and understanding which had

been a cornerstone for that success,”

said Louis Beecherl, Jr., Chairman of the

UT System Board of Regents.

Kern Wildenthal, MD, PhD, and Robert W. Decherd

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44

In July 1991, the U.S. Department of Health and Human Services and CDC released a major study, ”Healthy People 2000,” – a set of health indicators and objectives – and encouraged their use by public health officials nationwide. The report cited the following sta-tistics: of the top 10 leading causes of death in America each year, half were related to improper diet and lack of exercise; nearly 400,000 deaths were related to smoking, and more than 100,000 deaths were alcohol-related. Writing in the Foundation’s monthly newsletter, Charles Sprague, MD, President of Southwestern Medical Foundation, sagely addressed the topic:

“It is regrettable that there are so many people in the country demanding state-of-the-art medical care while at the same time doing nothing to modify their lifestyle, even in the face of known benefits from doing so. “Each of us has the responsibility to not only take advantage of such information in our own lives but also to encourage others to do so. The paradox is that not only does it cost little or nothing, but the savings in dollars and improved quality of life is enormous.” Nearly 25 years later, it remains a fundamental insight into the country’s national discussion on health care.

Charles C. Sprague, MD

UNITED STATES

1) The Whitehead Institute/MIT Center for Genome Research,Cambridge, Massachusetts

2) Washington University School of Medicine Genome Sequencing Center,St. Louis, Missouri

3) United States DOE Joint Genome Institute, Walnut Creek, California

4) Baylor College of Medicine Human Genome Sequencing Center, Department of Molecular and Human Genetics, Houston, Texas

5) GTC Sequencing Center,Genome Therapeutics Corporation, Waltham, Massachusetts

6) Multimegabase Sequencing Center, The Institute for Systems Biology,Seattle, Washington

7) University of Washington Genome Center, Seattle, Washington

8) University of Texas Southwestern Medical Center at Dallas, Dallas, Texas

9) University of Oklahoma’s Advanced Center for Genome Technology, Dept. of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma

10 ) Stanford Genome Technology Center, Stanford, California

11) Stanford Human Genome Center and Department of Genetics,Stanford University School of Medicine,Stanford, California

12) Cold Spring Harbor Laboratory,Lita Annenberg Hazen Genome Center, Cold Spring Harbor, New York

UNITED KINGDOM

13) The Wellcome Trust Sanger

Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom

FRANCE

14) Genoscope and CNRS UMR-8030,Evry, France

JAPAN

15) RIKEN Genomic Sciences Center,Yokohama, Japan

16) Department of Molecular Biology, Keio University School of Medicine,Tokyo, Japan

CHINA

17) Beijing Genomics Institute/Human Genome Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China

GERMANY

18) Department of Genome Analysis,Institute of Molecular Biotechnology,Jena, Germany

19) Max Planck Institute for Molecular Genetics, Berlin, Germany

20) GBF – German Research Centre for Biotechnology, Braunschweig, Germany

Ultimately, more than 1,000

researchers from six nations

participated in the Human

Genome Project (HGP) – the

United States, the United

Kingdom, France and Japan.

China and Germany would

join the effort later.

The vast majority of the

sequencing was performed

in 20 prestigious universities

and research centers.

UT Southwestern was one

of 12 in the U.S.

The Human Genome Project logo

n September 30, 1990, a monumental scientific undertaking called the Human Genome Project (HGP) officially began. It was considered the molecular biology equivalent of landing a man on the moon. Advances in gene sequencing and other recent discoveries had made it possible to imagine the project. But it was the promise of uncovering the genetic basis of disease that gave the idea an unstoppable momentum. Researchers from around the world agreed that deciphering the human genome would serve as the foundation upon which to build the science, medicine and health care of the 21st century. The scope of the project was enormous — estimated to take 15 years and cost as much as $3 billion. The National Institutes of Health (NIH) and the Department of Energy’s Office of Biological and Environmental Research were prepared to provide funding. Twenty of the world’s most prestigious biomedical research laboratories would ultimately be invited to contribute. UT Southwestern was one of 12 from the United States.

n the late 1980s, federal support for biomedical research began to fall. By 1991,although 94.7% of grant applications were recommend for approval, just over 25% were funded — down from a funding level of almost 40% four years earlier. A similar trend was occurring at the state level. The state of Texas was now providing less than 2% of UT Southwestern’s overall research budget. For fiscal year 1991– 92, support

dropped to $1.7 million from $2.4 million the year earlier. The medical school leadership determinedthat to continue to remain competitive with the best biomedical research facilities in the country, an additional $150 million was needed beyond the recent $100 million overall appropriation from the UT System. It was a bold decision — at the time, it

was the largest fundraising campaign for research ever undertaken by an American medical school and the largest private donor campaign of any kind ever attempted in Dallas.



The percentage of federal grants being funded fell from roughly 40% in 1988 to 25% in 1991.

“[Locating...the gene related to a disease is like] trying to find a burned-out light bulb

in a house located somewhere between the East and West Coasts without

knowing the state, much less the town or street, the house is on.”

Francis S. Collins, MDLeader, U.S. Human Genome Project

1988 1991

40%of approved federal grant applications

funded

25%of approved federal grant applications

funded

“The Human Genome will be the foundation of biology for decades, centuries

or millennia to come.”Sir John Sulston, FRSLeader, UK Human Genome Project

O

I

Members of the philanthropic community acknowledged the need and began their support. On December 4, 1991, UT Southwestern was able to announce that four gifts totaling

$85 million had been received. The O’Donnell Foundation gave a $25 million challenge gift to support neuroscience, cancer, developmental biology and genetic research. Erik Jonsson, co-founder of Texas Instruments and an ardent medical school supporter, gave $30 million in his capacity as President of the Excellence in Education Foundation. It was Eugene McDermott, Cecil Green and Jonsson — three founders of Texas Instruments — who had provided original funding for the foundation in the 1960s and 1970s. Nancy Hamon gave $25 million — $10 million to help complete what would become the Nancy B. and Jake L. Hamon Biomedical Research Building on the North Campus, and $15 million to establish two cancer

research centers and two distinguished chairs. Southwestern Medical Foundation pledged $5 million in a challenge grant to help raise matching funds for research. To complete the $150 million goal, a fundraising campaign called The Fund for Molecular Research was formally announced on October 29, 1992. It was co-chaired by two prominent Dallas businessmen: Lee Raymond, President of Exxon Corporation, and Liener Temerlin, Chairman of Temerlin McClain, one of the state’s largest advertising agencies. A total of 50 business and civic leaders stepped forward to serve on the campaign committee — many of whom were also prominent members of the Southwestern Medical Foundation Board.

a


46

Ross Perot congratulates Erik Jonsson, co-founder of Texas Instruments. As President of the Excellence in Education Foundation, Jonsson donated $30 million to the medical school. Standing at left are Drs. Michael S. Brown and Joseph L. Goldstein.

Drew Gaffney, MD, completed a fellowship in cardiology at UT Southwestern in 1977 and was a Faculty Associate and an Assistant Professor of Medicine. From 1979 to 1987, he served as Assistant Director of Echocardiography at Parkland. For the next two and a half years, Gaffney was a Visiting Senior Scientist with NASA’s Life Sciences Division. His 15 years of experience in cardiac research and operation of equipment such as echocardiographs and rebreathing devices led to his being selected in June

1991 as a payload specialist aboard STS-40 Columbia Spacelab Life Sciences (SLS 1), the first Spacelab mission dedicated to a single discipline: the life sciences. Gaffney was a co-investigator on an experiment studying the effects of weight-lessness on the circulatory system, the largest of 20 experiments performed during the flight. He logged more than 218 hours in space aboard the Columbia Spacelab. The primary test subjects aboard the shuttle mission were the astronauts, 30 rodents and thousands of tiny jellyfish.

Liener Temerlin ( left ), Chairman of Temerlin McClain; Kern Wildenthal, MD, PhD, President of UT Southwestern; and Lee Raymond ( right ), President of Exxon Corporation. Temerlin and Raymond co-chaired The Fund for Molecular Research.

Drew Gaffney, MD



John D. Minna, MD, one of the foremost lung cancerresearchers and clinicians in the world, is appointed Director of the Harold C. Simmons Comprehensive Cancer Center and later leads UT Southwestern’s burgeoning cancer program.____________Richard B. Gaynor, MD, a graduate of UT Southwestern, considered one of the top investigators in the field of AIDS research, joins the Departments of Internal Medicine and Microbiology.____________Southwestern Medical Foundation creates the Community Service Award to honor individuals who have provided significant support to the improvement of medical education, medical research and patient care. ____________

Construction on the first North Campus research tower, the Simmons Biomedical Research Building, begins.____________Gordon Green, MD, who earned his medical degree at Southwestern Medical School, is appointed Dean of the School of Allied Health Sciences at UT Southwestern. Previously, he had done a six-year tour of duty with the United States Public Health Service, after which he became the Director of the Dallas County Department of Health. He would go on to become President of the Dallas County Medical Society and a Foundation Board Member.____________The Algur H. Meadows Diagnostic Imaging Center nears completion. It will serve as an imaging facility for both Zale Lipshy and Parkland hospitals. The Meadows Foundation gave $1.5 million to build the center.____________The Foundation receives two separate pledges from the Collins family totaling $2 million in honor of Jim Collins, former eight-term U.S. Congressman from Dallas.____________Margaret Thatcher visits UT Southwestern.

In recognition of Drew Gaffney’s June 1991 NASA flight on Spacelab Life Sciences 1, the campus designs a “Southwestern in Space” logo, used on publications, T-shirts and bumper stickers.

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1 9 9 3


48

The Foundation’s Community Service Award is presentedto seven remarkable individuals: Cecil H. Green, J. Erik Jonsson, George L. MacGregor, Margaret McDermott,Edith and Peter O’Donnell, Jr., and Ralph B. Rogers in celebration of Southwestern Medical School’s 50th anniversary. ____________Survivors of the Branch Davidians fire near Waco are rushed to the Parkland burn unit for treatment.____________The Simmons Biomedical Research Building is dedicated. ____________Hoblitzelle Foundation pledges $1.25 million to the Foundation for The Fund for Molecular Research to establish and equip a neuroscience laboratory on the North Campus.

The Fund for Molecular Research, a $150 million campaign, is formally announced — at the time, the largest fundraising campaign for research ever undertaken by an American medical school.____________ UT Southwestern researchers begin using a “gene gun” to shoot DNA-coated micro-projectiles directly into the cells of animals. It was hoped the technique would lead to new ways of immunizing people against viral infections. ____________The Prostate Disease Center, a collaboration between UT Southwestern and Zale Lipshy, is formed to integrate internationally known research with superb clinical skills of the physician staff.____________Forty-two out of the 50 Dallas doctors named in the 1992 edition of "The Best Doctors in America" are UT Southwestern faculty.____________ The Institute for Exercise and Environmental

Medicine, a joint venture between UT Southwestern

and Presbyterian Hospital, opens. The brainchild of

Benjamin D. Levine, MD, UT Southwestern Assistant

Professor of Internal Medicine, its mission is

to use techniques of exercise and environmental

physiology to better understand the limits of human

functional capacity in health, aging and disease.Benjamin D. Levine, MD

1 9 9 2

In 1993, the Foundation sponsors a Human Genome Project Symposium during UT Southwestern Alumni Week on the occasion of its 50th anniversary. Nobel Laureates Drs. James Watson, Francis Crick, Joe Goldstein and Mike Brown headline a distinguished roster of speakers. While speaking at an anniversary dinner, Eugene Braunwald, MD, Chairman of the Executive Committee of the Department of Medicine at Harvard Medical School, remarks: “There are many fine museums in the country, but only one National Gallery of Fine Art. There are many fine musical institutions, but only one Metropolitan Opera. Likewise there are many excellent medical centers, but only one University of Texas Southwestern Medical Center.” High praise indeed.

Eugene Braunwald, MD


he completion of the Simmons Biomedical Research Building in 1993 was a landmark achievement. The building was designed to accommodate a mix of basic science and clinical researchers. Laboratory space could be customized to meet the needs of specific kinds of research. In combination with the unique esprit de corps that existed between departments, the new building became a powerful recruiting tool to attract and hold a critical mass of “movers and shakers.” During the 1990s, hundreds of researchers and clinicians were recruited, including John Minna, MD, world renowned as a leader in the genetics of lung cancer; R. Sanders Williams, MD, an internationally recognized researcher and highly regarded clinician and teacher in molecular cardiology; and Luis Parada, MD, one of the most-cited research scientists in developmental biology in the world at the time.


“There’s a very synergistic working environment. That’s one

of the things that attracted me.” Luis F. Parada, PhD Director of the Center for

Developmental Biology

This sample caption copy. It is here to indi-cate the visual weight of a caption and to suggest the approx-imate length of the caption. Please do not read t at this time..

In 1988, shortly after the land was acquired

from the John T. and Catherine T. MacArthur

Foundation by UT Southwestern, Harold

Simmons made an unprecedented $41 million

commitment that would begin development

of the North Campus. At the time, it was

the largest philanthropic gift in Dallas history

and ranked as one of the largest donations

ever made for medical research in the U.S.

The commitment included funds to

complete the Simmons Biomedical Building,

provide additional funding for cancer

research and help establish the Harold C.

Simmons Comprehensive Cancer Center.

Simmons’ support of Southwestern Medical

Foundation became exceedingly important

in advancing scientific and medical research at

UT Southwestern.Harold and Annette Simmons

The Simmons Biomedical BuildingThe 11-story Simmons Biomedical Building opens in 1993. It is the first research tower constructed on the North Campus and is named in honor of the late Reuben Leon and Fairess Clark Simmons, parents of Harold Simmons.

FEATURED DEPARTMENTS, LABS, CENTERS AND PROGRAMS

» Multiple Neuroscience Research Labs

» Developmental Biology Program ( funded by a gift from the Excellence in Education Foundation)

» Department of Pathology ( two floors )

» The Harold C. Simmons Comprehensive Cancer Center

» The Cancer Immunobiology Center

» Eugene McDermott Center for Human Growth and Development

» The Program for Excellence in Postgraduate Research

» Frank M. Ryburn, Jr. Cardiac Center

T


50

ale Lipshy Hospital was also attracting outstanding specialists. The medical center expanded its list of medical specialties to include pain management, auditory and facial nerve disorders, prostate cancer, lung cancer and breast cancer — and the hospital began to attract patients from all over the country. “A lot of schools had one star here and there,” Maddrey recalled. “We were building teams of stars.”

he first Gulf War began in 1990 and ended the following year. Some 700,000 soldiers — 100,000 from Texas — were sent to liberate Kuwait from Saddam Hussein. When the veterans returned home, thousands of men and women streamed into veterans hospitals complaining of memory loss, cloudy thinking, balance problems, insomnia, constant headaches and body pain. As many as 100,000 were thought to be affected. Physicians had no explanation for their symptoms and assigned a diagnosis of post-traumatic stress disorder (PTSD). Affected veterans insisted something far more serious

was wrong, but skepticism regarding the legitimacy of their illness grew. “It [was] very hard not being believed, being told it’s all in your head,” a top Special Forces officer explained. Ross Perot, who had long been known as a steadfast supporter of Vietnam POWs and injured veterans, fielded dozens of distressed calls from men he knew before the war — veterans who had looked forward to promising careers but were now struggling with the most basic aspects of daily living. “It was obvious these men had been wounded,” Perot said. In 1994, Perot approached UT Southwestern specialists for help. When diagnosis and treatment proved elusive, Perot was introduced to Robert W. Haley, MD, Director of the Division of Epidemiology. Perot proposed a $1.5 million grant to investigate “Gulf War Syndrome.” Haley agreed. When he began, Haley neither accepted nor rejected the idea that Gulf War veterans were suffering from post-traumatic stress. But after several years of research, enabled by additional funding from Perot, he came to the conclusion that many veterans had indeed suffered brain injuries that were likely caused by exposure to low levels of sarin gas, pesticides and anti-nerve-gas pills. The Defense Department and Veteran’s Administration were unconvinced and continued to believe that combat stress was the correct diagnosis.

Determined to answer the many unexplained questions, Haley and his team continued their research with financial support from Perot and the medical center’s blessing.

Robert W. Haley, MD

Outside Dallas, H. Ross Perot is perhaps

best known for being an independent

presidential candidate in 1992 and 1996.

In 1962, Perot founded Electronic Data

Systems (EDS) and sold the company

to General Motors in 1984. In 1988, he

founded Perot Systems Corporation.

Perot was born in Texarkana, Texas.

He became an Eagle Scout in 1942 and

attended Texarkana Junior College

before entering the U.S. Naval Academy

in 1949. In 1956, Perot married

Margot Birmingham.

Z

T



Alfred G. Gilman, MD, PhD, is awarded the Nobel Prize in Physiology and Medicine, making UT Southwestern home to more Nobel Laureates than any other medical school in the world.____________In September, Southwestern Medical Foundation sponsors an important public forum. The event features Nobel Laureates Drs. Michael Brown and Joseph Goldstein discussing the Human Genome Project and some of the ethical questions it raises, which draws an unexpectedly large crowd of more than 1,000 people. “We had no idea we would have such a tremendous response,” Sprague says.____________Paul Bass, Jess Hay and Donald Zale receive Southwestern Medical Foundation’s Community Service Award.____________Jean and J. Thomas Walter, Jr. pledge $1 million to establishthe Jean Walter Center for Movement Disorders.____________Parkland Memorial becomes the first hospital in Texas to win the prestigious Foster G. McGaw Prize for Excellence in Community Service.____________

____________The General Clinical Research Center (GCRC) at UT Southwestern celebrates its 20th anniversary as one of the oldest federally funded clinical research centers in the nation. It has been home to pioneering research in areas such as cholesterol metabolism, diabetes, osteoporosis, hypertension, neurological disorders and space medicine. Charles Pak, MD, serves as principal investigator, a position once held by Donald Seldin, MD.

Following NASA’s award of $5 million to UT Southwestern for space medicine research, NASA’s only Specialized Center of Research and Training in Physiology is established.

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In December, a handwritten note addressed to Dr. Sprague arrives without ceremony in Southwestern Medical Foundation’s office mail.

Charlie — Have you ever been informed that the Foundation is in my will with probability of over $1,000,000? Okay? Holiday Best Wishes to you — Louise

The note is from Louise Kahn, who will pass away a year later, leaving a percentage of her estate to the Foundation. The donation (more than $1 million ) will be used tocreate the Louise W. Kahn Scholar in Biomedical Research.


52


a basic discovery should be looked upon as sort of an underground

spring that nourishes many oases in the desert. So when people ask,

‘What practical benefit is Al Gilman’s work going to be?’ it’s like asking, ‘What

can you grow from an underground spring?' Pretty soon we’re going

to have a beautiful garden all nourished by the kind of work he has done —

the revolutionary work that exposed a whole new aspect of biology

that no one, frankly, knew existed before.”

Michael S. Brown, MD, Nobel Laureate

nobody wins the Nobel Prize. You earn the Nobel Prize.”

Ross Perot

nobel week in Stockholm is one giant party that goes on from morning

to night and never seems to end. Al can look forward to a gala week — full of

protocol, alcohol and cholesterol. My advice to Al, the pharmacologist,

is to take along some Tylenol.”

Joseph L. Goldstein, MD, Nobel Laureate

52

“

“

“

NO.4

and then it happened again. Great intellect, dogged determination and relentless curiosity were rewarded on October 10, 1994, when the Nobel Prize Committee announced that Alfred G. Gilman, MD, PhD, Chairman of the Department of Pharmacology, had won the 1994 Nobel Prize in Physiology or Medicine for his discovery of G-proteins and the role they play in cellular communication. He shared the prize with Martin Rodbell, MD, at the National Institute of Environmental Health Sciences in North Carolina. Gilman had maintained his intense focus over the course of three decades, earning himelection to the National Academy of Sciences (1985), the American Academy of Arts and Sciences (1988), and the Institute of Medicine (1989) and garnering him the Lasker Award (1989), among others. But nothing quite compares to becoming a Nobel Laureate. “Someday you’ll be able to design a drug that works on only the molecule you want to target and on no other molecules in the human body,” Gilman predicted at the time. G-proteins rest at the inner surface of the cell membrane. When a neurotransmitter or hormone arrives outside the cell, it doesn’t enter the cell directly; instead, it binds to a receptor on the cell’s surface. This attachment triggers a specific G-protein, one of many, to switch from “off” to “on.” The activated G-protein enlists other proteins to begin specific cellular activities. Gilman found that each G-protein has a “timer,” allowing the cellular activity

to continue only as long as the G-protein remains “on.” In addition, he found that any disruption in the normal operation of “off to on” and “on to off” might lead to disease, even cancer. His groundbreaking research incited untold numbers of researchers around the world to further the understanding of the roles G-proteins play in human disease. Gilman acknowledged the support of his research team, which especially included Elliott Ross, PhD, and Paul Sternweis, PhD, both of whom became independent investigators in the Department of Pharmacology. He later wrote, “It is easy to be a successful Chair in Dallas; our administration, particularly President Kern Wildenthal and Dean William Neaves, and local philanthropists ensure it.” UT Southwestern was now home to four Nobel Laureates — more than any other medical school or research institute in the world — anunprecedented achievement even among the most elite universities.


Gilman and his team used leukemia cells to identify and demonstrate G-proteins, which receive multiple signals from outside the cell, integrate them and control fundamental life processes within the cell.

“My reaction? First I activated my receptor, then my G-protein, etc.

I was extremely excited. I think I secreted all the adrenaline

I had. Then I poured myself a big glass of Coke, because I was suddenly

thirsty, and I proceeded to spill it allover the telephone

when the first reporter called.” Alfred G. Gilman, MD, PhD Nobel Laureate



54

hroughout the country, articles on diet, active lifestyles and the health benefits of certain foods appeared with greater frequency. They contained a steady stream of do’s and don’ts and, on occasion, contradictory information. By the mid-1990s, the inconsistencies of dietary advice became more generally recognized. In 1994, the New England Journal of Medicine raised the question: “What should the public believe?...They substitute margarine for butter, only to learn that margarine may be worse for the arteries. They are told to eat oat bran to lower their cholesterol, but later learn that the bran they dutifully ate may be useless.” One of the unintended consequences of the nation’s “fat-free crusade” to lower cholesterol was that much of the public came to believe that if their food didn’t contain fat, eating it wouldn’t make them fat. The food industry substituted trans fats for animal fats, which at the time were seen as a healthier alternative to saturated fats, and replaced calories from fat with sugar, leaving many “low-fat” food products with the same calorie content. The great irony was that with the introduction of more and more fat-free and reduced-fat products, Americans

grew fatter. The focus on fat calories to the neglect of carbohydrate calories contributed — along with a more sedentary lifestyle and other factors — to an alarming obesity epidemic sweeping the country. Up until the early 1980s, obesity rates across America had remained between 12% to 14%. But by 1990, rates had risen to 25% and, perhaps of greater concern, were continuing to rise. Across the medical school, research began to focus on the metabolic syndrome, a field of study defined by a group of conditions — increased blood

pressure, a high blood sugar level, excess body fat around the waist and abnormal cholesterol levels — that occur together, increasing the risk of heart disease, stroke and diabetes. Along with statin research, which was showing how powerful the drug was in

reducing heart attacks, “the metabolic syndrome was something many at Southwestern became extremely interested in understanding,” Grundy said.

“Our emphasis began to shift as it became clear that the obesity problem

in America had become significant.” Scott Grundy, MD, PhD

Ironically, the fat-free and low-fat diet crusade helped contribute to America’s obesity epidemic.

Scott Grundy, MD, PhD, Director of the Center

for Human Nutrition, is a pioneer in research

involving cholesterol and lipoprotein

metabolisms. He became one of the prime

movers in helping American physicians

recognize metabolic syndrome as an

important risk factor for heart disease.

T



The Fund for Molecular Research ends, surpassing its $150 million goal by more than $8.5 million.____________Charles C. Sprague, MD, receives Southwestern Medical Foundation’s Ho Din Award.____________The Heritage Society of Southwestern Medical Foundation is created to recognize individuals who have made a planned gift or have included a bequest to the Foundation in their wills.____________The Foundation’s Community Service Award honors Ruth Altshuler, Annette and Harold Simmons,and Joe M. Dealey.____________J. Erik Jonsson, former Dallas Mayor, co-founder of Texas Instruments and longtime supporter of Southwestern Medical Foundation and UT Southwestern, dies.____________James W. Aston dies, leaving the Foundation and the entire Dallas community enriched by nearly 50 years of his visionary leadership.____________

Paul M. Bass (far left) is elected Chairman of Southwestern Medical Foundation, and W. Plack Carr, Jr., a member of the Foundation Board since 1992, is elected President.

1 9 9 5

During the 1990s, managed care displaced indemnity insurance to become the dominant form of private-sector health insurance. Between 1987 and 1997, privately insured Americans enrolled in Health Maintenance Organizations (HMOs) increased from 16% to 48% nationally. Over the same period, those enrolled in Preferred Provider Organizations (PPOs) increased from 11% to over 25%. The tremendous growth of managed care organizations had significant effects on the health care market, among them the competitive pressures placed on other providers leading them to reduce

costs and/or quality of care. Zale Lipshy, like most university hospitals across the country, suffered an additional financial disadvantage. University hospital operations had far greater overhead: medical student educational programs, clinical research activities, and the need for the latest medical equipment and technology. As a result, Sprague, acting in his role as President of the Foundation, madethe appeal for donations earmarked to help Zale Lipshy maintain its reputation for excellence. It was an appeal heard and acted on by the caring people of the Dallas community.

The 1990s were a period of rapid growth in managed care.


56

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Nancy Hamon worked in Hollywood

and appeared in several 1940s films before

returning to Texas and marrying famed oilman

Jake Hamon in 1949. After the deaths of

her son in 1984 and her husband in 1985, she

devoted her life to philanthropy.

Mrs. Hamon’s gifts to UT Southwestern

included a $25 million donation in 1994 to the

Fund for Molecular Research campaign;

$15 million of that gift established the Nancy

B. and Jake L. Hamon Center for Therapeutic

Oncology Research, the Nancy B. and Jake L.

Hamon Center for Basic Research in Cancer

and two Distinguished Chairs in those fields.

The remaining funds were used to help

construct the Nancy B. and Jake L. Hamon

Biomedical Research Building.

In the 1980s, the Hamons, through Dr.

Bryan Williams at the medical school, realized

that many of the students were in need

of housing but had limited funds. Williams

arranged for some of the students to live in the

Hamons’ guesthouse, and they worked for the

couple by driving them to various functions.

In 1999, Mrs. Hamon gave a $4 million

challenge grant to launch a campaign to build

the Bryan Williams, MD, Student Center.

The campaign was co-chaired by Charles A.

Sanders, MD (class of ’65), and Fred Lucas,

MD (class of ’61).

“I wanted to do something at the medical

school that would honor Bryan Williams

for all those years he spent helping students,”

Mrs. Hamon said. “So when he mentioned that

they didn’t have any place to relax or exercise,

I told him I would like to help.”

In 1994, Mrs. Hamon received the

Linz Award, which honors a Dallas County

resident’s humanitarian and civic efforts.

“Nancy Hamon’s philanthropy is legendary.

Her continued support of Southwestern

Medical Foundation and UT Southwestern has

turned countless dreams into reality,” said

then Foundation President W. Plack Carr, Jr.

Nancy Hamon

The eight-story Hamon Biomedical Research Building opens in 1995. It is the second research tower to be completed on the North Campus and is named in honor of Nancy B. and Jake L. Hamon.

FEATURED DEPARTMENTS, LABS, CENTERS AND PROGRAMS

» Department of Molecular Biology and Oncology

» Department of Microbiology

» Hamon Center for Basic Research in Cancer

» The Molecular Immunology Center

» McDermott Genome Science and Technology Center

» Genetics and Development Graduate Program

» Molecular Microbiology Graduate Program

The Hamon Biomedical Research Building

[ CONT. ]

hilanthropy can create an unbroken path to the future where one good thing leads to another. But a proper appreciation of its longer-term effects takes closer examination. The following account from the mid-1990s is an excellent example. UT Southwestern was actively pursuing Glen A. Evans, MD, PhD, who was working at the Salk Institute for Biological Studies in California. Evans was world renowned for having established one of the nation's first and finest genetic research centers. The medical center wanted him as the Director of the Eugene McDermottCenter for Human Growth and Development and to lead UT Southwestern’s participation in the Human Genome Project. Eugene McDermott had established the farsighted Center in 1973, shortly before his death in August that same year. It was one of many generous and visionary acts he and his wife, Margaret, had made in support of UT Southwestern with the elegant and noble goal of “maximizing everyone’s capacities for thinking and doing.” The Biological Humanics Foundation, then headed by Mary McDermott Cook and established by her father in 1950, donated its last and largest gift of

$6 million, with almost $5 million earmarked to further enhance the Center. The gift was then matched by monies from The Fund for Molecular Research. The total endowment allowed the medical school not only to attract a researcher of Evans’ stature, but to move his team of scientists, technicians — even his equipment — from California to Dallas, where they took over 10,000 square feet located in the newly completed Nancy B. and Jake L. Hamon Biomedical Research Building on the North Campus. “We were very fortunate in moving to an institution where the administration is so forward-thinking and, in fact, confident about their ability to recruit from elsewhere. Skip Garner ( Evans’ assistant director) and I had designed the entire 10,000 square feet

of laboratory space. It [had] a lot of unique features… [and] was actually under construction before we ever committed to coming to Southwestern, which shows the confidence they had that we wouldn’t turn them down,” Evans recalled. Few academic medical centers in the country could have put together such an offer. But few medical centers have the broad, committed support of a medical foundation determined to push them forward. Evans and Harold “Skip” Garner, Jr., PhD, who was trained as a nuclear physicist, went on to make a difference. Evans led a team that completed the sequencing of chromosome 11 — work he had begun at the Salk Institute.


Mary McDermott Cook, daughter of Margaret and Eugene McDermott,continued the family’s philanthropic legacy.

“What we’re accomplishing here,we couldn’t have done anywhere else.”

Glen A. Evans, MD, PhDDirector of the Eugene McDermott Center for Human Growth and Development


Glen Evans, MD, PhD, one of the

world’s research leaders in the Human

Genome Project, was recruited

from the Salk Institute in California.

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58

From the outset, Garner and Evans focused their efforts on automation. Garner developed automating sequencing technology, which used three custom robots to do much of the repetitive work. One of them ran 24 hours a day, seven days a week, preparing samples to go in the sequencing machine. It proved amazingly efficient — capable of preparing 15,000 samples a day, as opposed to the 200 samples a human technician could prepare. The innovations led to something unique among sequencing labs. Evans declared that instead of a “laboratory full of bored, uninspired technicians,” his sequencing team had “the time to study the biology of what these [discoveries] mean.” It was philanthropy that made this possible – a contribution of vision and generosity, effort and discrimination that resulted not just in a series of good things for UT Southwestern but of good things for mankind. This is but one of dozens of examples that did much to help the medical center grow.

n 1995, the Fund for Molecular Research campaign was ending. The effort had been a monumental success, surpassing its $150 million goal by more than $8.5 million — an unprecedented accomplishment aided by the hard work of the Campaign Committee and Southwestern Medical Foundation and achieved through the extraordinary generosity of the people of Dallas.

“Since Evans’ arrival, his program [has] grown to become one of the largest

Human Genome Centers in the country…he and his colleagues [have

been] awarded multiyear grants totaling over $20 million.”

Kern Wildenthal, MD, PhD President, UT Southwestern

Unlike those involved with most “big science” research projects,

researchers with the Human Genome Project didn’t have to wait for the

work to be complete before they could get results.

Among the first genes identified by the medical center’s Genome

Science and Technology Center (GESTEC) was one linked with hereditary

multiple exostoses type 2 – a disease that disrupts bone growth and

predisposes its sufferers to bone cancer – found on chromosome 11.

It was announced by Glen Evans, MD, PhD, and Michael Lovett, PhD.

Before genetic researchers can identify how a gene might affect

disease and health, they first have to find it. Lovett was a skilled

gene mapmaker who developed a technology that sped up the process

of finding and analyzing genes. One gene, BRCA1, which is involved

in familial breast cancer, was isolated (at other institutions) with the type

of technology Lovett developed.

UT Southwestern researchers were also investigating Wilms’ tumor,

a kidney cancer most common in children, and long QT syndrome,

a heart disease that was thought to be the cause of cardiac arrest in

young adults, among others.

A human karyotype showing 22 chromosome pairs, plus an XY (male) sex chromosome pair, under a simple light microscope.

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59

Eric Olson, PhD, is recruited as Chairman of new Department of Molecular Biology and Oncology.____________ The name of Southwestern Medical Foundation’s Community Service Award is changed to the Charles Cameron Sprague Community Service Award in honor of Dr. Sprague, who is at the time both President Emeritus of UT Southwestern and Chairman Emeritus of the Foundation.____________The Perot Foundation donates an additional $23.3 million to continue the Medical Science Training Program (MSTP) and enhance biomedical research. ____________For the second time in three years, Kimberly-Clark Corporation pledges $1 million to the Foundation to benefit research at UT Southwestern.____________ Steven McKnight, PhD, becomes Chairman of the Department of Biochemistry. ____________

In 1996, Glen Evans, MD, PhD, Director of the Eugene McDermott Center for Human Growth and Development, gave a talk to members of the Philosophical Society of Texas about his work on the Human Genome Project. In describing his DNA sequencing lab, he referenced a more famous graduate of the Salk Institute, Michael Crichton. Crichton was a postdoctoral fellow of Jonas Salk but became better known as the author of Jurassic Park (1990), in which a commercial company sequences the DNA of dinosaurs after extracting it from insects embedded in amber. In the book, Crichton describes the sequencing laboratory as “two six-foot-tall

round towers in the center of the room; along the walls rows of waist-high stainless steel boxes. The boxes are...automated gene sequencers...being run by a Cray supercomputer.” “Without realizing it,” Evans explained, “Crichton described the laboratory that we constructed [ just ] two years ago here at Southwestern...using a battery of automated gene sequencers...and in our case, run not by a Cray supercomputer, which is obsolete...but by a Hewlett- Packard Exemplar parallel processing supercomputer.” He concluded: “In essence [ his ] description...is exactly what has come to pass.”

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S O U T H W E S T E R N M E D I C A L P E R S P E C T I V E S . F A L L 2 0 1 5

Despite concerns about chemical

food additives and the use of

pesticides on crops causing cancer,

a poor diet is likely to pose a far

greater risk, determines a National

Research Council committee

chaired by Ronald W. Estabrook,

PhD, Professor of Biochemistry at

UT Southwestern.

“Toxic chemicals that occur

naturally in foods may pose a greater

risk of causing cancer than the

residues of synthetic pesticides that

people consume in their diet.

But the danger of either group of

chemicals causing cancer is much

smaller than the risk associated with

diets containing too much fat,

too many calories or an excess of

alcohol,” the report concludes.

Ronald W. Estabrook, PhD


60

The Foundation receives a $1 million grant from the E.E. Fogelson and Greer Garson Fogelson Charitable Foundation to create a Distinguished Chair and expand the endowment of an existing Distinguished Chair.____________Robert W. Haley, MD, and his team’s ongoing research into Gulf War Syndrome confirms that neurotoxic brain damage from exposure to wartime chemicals is linked to a genetic predisposition.____________John Rutherford, MD, Professor of Internal Medicine, is one of the senior investigators on an important five-year study showing that lowering normal cholesterol levels can dramatically reduce the risk of a second heart attack. ____________Dorothy L. and John P. Harbin give $1 million tothe Foundation to enhance Alzheimer’s disease research.____________Robert T. Hayes makes a $1 million gift to the Foundationto fund psychiatric research.____________


Ross and Margot Perot are awarded the Foundation’s Charles

Cameron Sprague Community Service Award.

Earlier in the year, the Perot Foundation added an additional

$23.3 million to further enhance biomedical research and

continue the Medical Science Training Program ( MSTP ).

“It was vital to this country then,” Dr. Kern Wildenthal says,

referring to Perot’s original MSTP gift, “and even more so today

that these programs continue to grow to fill the nation’s

research needs.”

Among the Perot Foundation’s many gifts to UT Southwestern

are two of the largest pledges ever made to a public university or

medical school.

Ross and Margot Perot

1 9 9 7

Jonathan Uhr, MD, came to Texas when Donald Seldin, MD, then Chair of Internal Medicine, recruited him toChair the Department of Microbiology. Uhr was already an internationally known biomedical researcher. Dr. Uhr has been at the forefront of many seminal discoveries in immunology. He first demonstrated the role of passive antibody feedback — a body of work that led to the prevention of Rh disease. In 1997, he celebrated 25 years as Chair, having grown the Department from three faculty members to 27. That same year, he stepped down to join the Cancer Immunobiology Center, directed by one of his most accomplished

recruits, Ellen Vitetta, PhD. “When Jon Uhr recruited me here from New York, he made it clear that his goal was to create the best Microbiology Department in the country, with a very strong immunology component,” said Vitetta, an NAS member and one of the most highly cited researchers in the country. “When I saw the list of people he had brought on board...I knew it would be a fantastic place to work. I was not disappointed.” Vitetta would later train Linda Buck, PhD, who went on to become an NAS member and to win the 2004 Nobel Prize in Physiology or Medicine.

Jonathan Uhr, MD

n 1996, Steven McKnight, PhD, became head of the Department of Biochemistry, replacing Joe Sambrook, PhD, who had left for Australia.

McKnight was born and raised in Texas. He did his postdoctoral research at the Carnegie Institution of Washington, DC, became a staff member there in 1983, and was appointed a Howard Hughes Investigator in 1988. In 1991, McKnight left academia to co-found Tularik, a San Francisco-based biotechnology company. “Bill (Neaves) told me with quiet determination…that he fully expected me to end up at Southwestern once Tularik was on its feet. Brown and Goldstein

were equally adamant. This continued interest by the UT Southwestern leadership impressed me a lot,” McKnight recalled. McKnight’s recruitment was facilitated by a significant financial incentive provided by an anonymous Dallas donor. It would prove to be a farsighted decision.

aley and his research team continued their research of Gulf War syndrome. By 1997, they had confirmed that neurotoxic brain damage from exposure to wartime chemicals was linked to a genetic predisposition. Haley briefed the nation’s top military and political leaders and testified before Congress. Perot had called it the “ultimate insult” that the government had fought against thepeople it sent to war. Senator Kay Bailey Hutchison agreed with Perot and got involved. As Chairman of the Military Construction and Veterans Affairs Appropriations Subcommittee and a member of the Defense Appropriations Subcommittee, Senator Hutchison was in the perfect position to make a difference. “I couldn’t understand why we were spending so much money trying to prove it didn’t exist,” Senator Hutchison said. In 1998, she secured federal funding that allowed Gulf War syndrome research to continue, which resulted in research that played a pivotal role in the military’s recognition of the reality of Gulf War syndrome and the severity of its impact on veterans. Haley was able to show the presence of a gene that controlled the production of a specific enzyme that allowed the body to fight off chemical toxins by destroying them. This provided the explanation of why one person might be severely injured and the person standing next to him or her was not affected. Still, exactly how, when and where the troops had become exposed to the chemicals and how they damaged brain cells remained mysteries that would take Haley and his team of researchers another 15 years to uncover.


Steven McKnight, PhD


Thomas Kurt, MD, and Robert W. Haley, MD, review

magnetic resonance brain images. They collaborated

with Jim Hom, PhD, and other UT Southwestern faculty

on clinical and animal studies that demonstrated

harmless doses of three chemicals used to protect Gulf

War soldiers from insect-borne diseases and nerve-

gas poisoning are highly toxic to the nervous system

when used in combination.

At right is the January 15, 1997, cover of the Journal of the American Medical Association (JAMA), in which

their three initial papers on Gulf War illness were

published together – a feat that has never been done

before or since by a single research team.

I

H

n 1998, the O’Donnell Foundation helped establish the Endowed Scholars Program in Medical Science with a $25 million challenge grant. It inspired $35 million in additional donations — including $5 million each from the W.W. Caruth Jr. Foundation, the Virginia Murchinson Linthicum Trust and Southwestern Medical Foundation. While the Medical Scientist Training Program that Perot had funded was designed to attract top students, the Endowed Scholars Program was created to attract and retain the world’s best young faculty at the beginning of their careers. It offered a package of generous research support for a new faculty member’s first four years, as well as the opportunity to work side by side with Nobel-caliber mentors. The Endowed Scholars Program would prove extraordinarily valuable as many brilliant young men and women made the decision to continue their careers at the medical school.


Southwestern Medical Foundation recently sat down with Peter O’Donnell and invited him to share his memories and talk about the future.

SWMF: You were good friends with Philip

O’Bryan “P. O’B.” Montgomery. What can

you tell us about him?

O’DONNELL: I watched my friend Phil

Montgomery devote half a century to serving

UT Southwestern. He was an educator, a

researcher and an associate dean....For many

people in the community, he was an unpaid

consultant who referred them to experts at

the medical center for their health problems.

P. O’B. was the reason I got interested

in UT Southwestern. Early on, he asked me

to support a research project: the UV flying

spot microscope. From there I was hooked.

I remember in 1980, P. O’B. told me:

“Goldstein and Brown will win the Nobel

Prize.” In 1985, they did. In 1988, he said:

“Gilman will win it.” He had an eye for talent.

One day, I picked him up and we were

driving along on Inwood Road, by where the

North Campus is today, and he looked at

me and said, “We’ll need this land one day.”

SWMF: What remarkable insight.

O’DONNELL: I have thought about this a

lot. When recruiting talent – dollars, space

and colleagues are all critical. But if you don't

have the space, you're in trouble. Solving that

is the number one problem. We would have

been landlocked like so many other medical

schools. We are able to recruit and grow

today because we’ve got the land.

SWMF: Anything you can share about Don

Seldin?

O’DONNELL: It's impossible to overesti-

mate the impact he's had here. Seldin took

on Goldstein and Brown and mentored them.

Seldin spotted Al Gilman. I asked Al one time

how he'd gotten to UT Southwestern. Al was

at Case Western. He told me, “Dr. Seldin

came to see me, and in 45 minutes he blew

me away.” Seldin is an outstanding presenter.

Having that keen eye for talent has been

the difference maker. Goldstein and Brown

spotted Scott Grundy when I was deter-

mined to put the study of human nutrition on

scientific foundation at the school. It was a

bit of an uphill battle, beginning a Center for

Human Nutrition, but we got it done.

SWMF: It’s interesting that people needed

convincing.

O’DONNELL: I ran across a saying a long

time ago that I never forgot: “Obstacles are

what you see when you take your eye off the

goal.” I resolved to never take my eye off the

goal. I've had a long interest in nutrition and

systems biology, as well as in neuroscience

and the brain. If you are convinced of it, you

put your money into it.

SWMF: Brown and Goldstein?

O’DONNELL: They were exceptionally im-

portant during this period, no question. But I

think what’s so marvelous is that they contin-

ue to do important work and are incredibly

valuable to the school. That’s our roots,

and we’re still getting the benefit. I asked

Joe to join the Board of Cooper Aerobics

Center. He is quiet, but people really listen

when he speaks. He gets calls from all over

the world because what he and Mike Brown

are doing continues beyond their original

work. They're doing tremendous things.

SWMF: What do you see going forward?

O’DONNELL: I believe there is a strong need

to mentor young MDs who can be trained to

be clinicians. There is a human component

that shouldn't be left behind as we advance

technologically. An outstanding doctor and a

good friend at the school embodies this idea,

Dr. Gene Frenkel. I’d start with oncology and

roll it out through all the departments. My in-

terest extends to both physicians and nurses.

SWMF: Do you see your role over the years

through the lens of a businessperson?

O’DONNELL: I’m not a businessperson; I’m

an investor. But in the case of the medical

school, the return on investment is not mea-

sured in profits but in enduring and positive

leadership.

SWMF: On behalf of the Foundation and

the medical school, we thank you and Edith

for your tremendous vision, tenacity and

extraordinary generosity.

Peter and Edith O’Donnell

62

I



Beginning in 1998, The Cain Foundation, William P. Clements, Jr., Thomas O. Hicks, Nancy Cain and Jeffrey A. Marcus, the McDermott Foundation, Deborah and W. A. “Tex” Moncrief, Jr., and Michael L. Rosenberg each give $1.25 million to the Endowed Scholars Program.____________

____________

____________

____________Bob Smith, MD, donates $1 million to the Foundation to fund prostate research.____________ Woodring Wright, MD, PhD; Jerry Shay, PhD; and their collaborators report that the enzyme telomerase causes human cells grown in the laboratory to retain their “youth” – continuing to divide long past the time they normally stop.

Sydney and J.L. Huffines donate

$1 million to Southwestern

Medical Foundation to establish

a Distinguished Chair in cancer

research in honor of Eugene

Frenkel, MD. Frenkel, a Professor

of Medicine in the Harold C.

Simmons Comprehensive Cancer

Center, joined the faculty in 1962.

He is a hematologist/oncologist

whose research on transport

mechanisms of vitamin B12 led to

studies of drug delivery and drug

resistance in cancer chemothera-

py. “Dr. Frenkel is a very, very fine

person,” Huffines said, “...one of

the last old-time doctors with a

true bedside manner. He is more

than deserving of any honor.”Eugene Frenkel, MD

William B. Neaves, PhD, who joined

the UT Southwestern faculty in 1972 as

Assistant Professor of Cell Biology, is

appointed Executive Vice President for

Academic Affairs while continuing as

interim Dean of the Medical School.

“Bill has always played a crucial

role in recruiting and retaining gifted

faculty members and in enhancing our

international prominence in education,

research and clinical programs,” says

Dr. Kern Wildenthal.

Before the North Campus was

developed, Neaves held to an unwavering

vision: “I want to stress that the North

Campus should not and cannot

become a site devoted exclusively or

predominately to basic research.

“My goal...is to see it evolve with

a mixture of basic and clinical faculty

characteristic of the successful develop-

ment of our main campus. I’m referring

to the ability of people from different

departments and disciplines – basic on

the one hand and clinical on the other –

to walk down the hall and interact

with each other and form affinity groups

based on their common interest in

a particular biomedical problem.”

It was a vision now underway.

Bill Neaves, PhD

1 9 9 8

Eric Olson, MD, Chairman of Molecular Biology and

Oncology, and his team discover both a molecular

pathway that leads to heart enlargement and a way

to block it using a drug already approved by the

FDA (but for another condition).

Eric Olson, MD

Adelyn and Edmund M. Hoffman donate $1 million to establish a Distinguished Chair in support of the medical center’s growing clinical program. Adelyn will later establish a $5 million fund for research in DNA-based epidemiology.____________

____________


64

1 9 9 9

In 1993, a gift of $10 million from Charles

E. and Sarah “Sadie” Seay helped build the

Seay Biomedical Building, the third tower

on the North Campus.

The Seays met as students at UT Austin

and married in 1937. Charlie Seay began

his career as an insurance agent and later

launched his own business, specializing in

life insurance stocks.

For more than half a century, the Seays

were legendary champions of children.

Their gift of $11.5 million established the

Sarah M. and Charles E. Seay Comprehensive

Center of Pediatric Emergency and Intensive

Care through a charitable remainder trust at

Southwestern Medical Foundation.

The Seays endowed five Centers, three

Distinguished Chairs and four Chairs – one in

pediatric infectious diseases.

In the early 1950s, the couple helped

fund the first pediatric intensive care unit

at Bradford Hospital for Babies, which later

became Children’s Medical Center.

In the 1960s, the Seays enabled Children’s

Medical Center Dallas to establish the first

pediatric psychiatric facility in the area.

Their donations in the 1970s, 1980s and

1990s also made possible the Sarah M.

and Charles E. Seay Emergency Referral

Center and the Seay Intensive Care Unit at

Children’s and the Luke Waites Child

Development Center at Texas Scottish

Rite Hospital.

“They are two of the most unselfish

people I have ever known,” said Paul Bass,

Chairman of the Foundation.

Charles E. and Sarah Seay

The eight-story Seay Biomedical Building opens in 1999 — the third research tower to be built on the North Campus.

FEATURED DEPARTMENTS, LABS AND CENTERS

» Clinical facilities for Internal Medicine, Psychiatry and Surgery

» Seay Center for Basic and Applied Research in Psychiatric Illness

» The Simmons Comprehensive Cancer Center

» The Center for Biomedical Inventions

» Outpatient clinics for psychiatry and cancer patients

The Seay Biomedical Building

Kenneth Altshuler, MD, Chairman of the

Department of Psychiatry at UT Southwestern,

was influential in advising Charles and Sarah

Seay on the needs of the medical school

and the community in psychiatric research

and treatment and in gaining the Seays'

support. Altshuler had built the department

to national stature and scientific reputation.

In 1999, then Governor George W. Bush

appointed him a member of the Board

of Directors of the Texas Department of

Mental Health and Mental Retardation.

Kenneth Altshuler, MD

n the late 1990s, the head of Cardiology, R. Sanders Williams, MD, told Helen Hobbs, MD, about a call for applications from the Donald W. Reynolds Foundation in Las Vegas. The Reynolds Foundation was offering what would become a 10-year, nearly $60 million grant to create a Center for Cardiovascular Disease research. “I wasn’t very enthusiastic about it,” Hobbs recalls. Her lab had recently identified two recessive forms of severe high cholesterol, an exciting discovery that called for its own new research. That and the sheer size of the grant, which ensured a crowded field of the country’s top academic medical centers, made the opportunity a long shot at best. Ultimately, however, Hobbs and Ron Victor, MD, now Director of the Hypertension Center at Cedars-Sinai's Heart Institute in Los Angeles, accepted the challenge and became Co-Principal Investigators. After the initial review, UT Southwestern emerged as one of the five finalists —an elite group that included Johns Hopkins, Duke, Harvard and the University of California at San Francisco. The centerpiece of the medical school’s proposal was the Dallas Heart Study (DHS), which incorporated a sample population of more than 6,000 adults from Dallas County. The study combined the best features of laboratory and population-based research. Its key design feature —captured in its theme: Taking Diversity to Heart — was to effectively leverage the genetic diversity in Dallas. The goal was to identify new genetic, protein and imaging biomarkers that could detect cardiovascular disease at its earliest stages. It was also designed to examine the social, behavioral and environmental factors contributing to cardiovascular risk in order to find effective interventions. In 1999, the team's efforts were rewarded with the first of many Reynolds Foundation grants going to UT Southwestern. The result was the establishment of the Donald W. Reynolds Cardiovascular Clinical Research Center, a multidisciplinary collaboration among geneticists, epidemiologists, and clinical and molecular biologists. Over the next 25 years, the collaboration would lead to the discoveries of major genes and proteins that contribute to heart and metabolic disease. The Dallas Heart Study has become one of UT Southwestern’s greatest research projects. The data gathered has been, and will continue for decades to be, an invaluable resource to young cardiologists in clinical research as well as to those in related fields such as obesity and liver disease.


Helen Hobbs, MD, Howard Hughes Medical Institute Investigator and Professor of Internal Medicine and Molecular Genetics

“We’re one of the few places in the world that has people working on the

fundamental mechanisms of heart disease as well as on improving care

to individuals in the community.” Helen Hobbs, MD


I


66

he Moncrief Radiation and Research Foundation, chaired by W. A.“Tex“ Moncrief, Jr., had awarded the Moncrief Radiation Center in Fort Worth to the UT System in 1995. But in 1999, Moncrief made the decision to transfer ownership so that it could be staffed and managed by UT Southwestern.

Moncrief was a Fort Worth oilman and patriarch of one of Texas’ first families of philanthropy, having learned the importance of giving from his parents, W.A. “Monty” and Elizabeth Moncrief. The Moncrief Radiation Center, which had been renamed Moncrief Cancer Resources, was one of the first community radiation facilities in the country. The physical plant and equipment were valued at $30 million, and the Moncrief Foundation’s endowment had, by 1999, grown to $60 million. Together, the $90 million donation represented the largest single philanthropic gift ever

received by a university or medical center in Texas at that time. “Tex and Deborah Moncrief rank among the most generous philanthropists in America,” Wildenthal said. “Beyond that, they are — purely and simply — just wonderful, good people.” Southwestern Medical Foundation and the medical center were blessed to count among their friends many wonderful, good people — compassionate and generous men and women, families and foundations committed to making a difference in the lives of others. And, remarkably, seen as one philanthropic community, they were just getting started.

Deborah and W. A.“Tex” Moncrief, Jr.

As the millennium approached, the changes that

had occurred across the health care landscape in

Dallas were nothing short of remarkable.

A mere 60 years after Southwestern Medical

Foundation was founded and 56 years since

Southwestern Medical College opened, the medical

school had some 1,900 research projects underway,

totaling more than $166 million.

During the 1998 –1999 academic school year,

UT Southwestern was educating 794 medical

students, 435 graduate students, 365 PhD

graduate students, 70 master’s graduate students,

319 health professions students, 250 bachelor’s

degree students, 40 post-baccalaureate

undergraduate students and 29 professional

master’s students.

In 1999, UT Southwestern’s faculty and residents

provided care to almost 75,000 hospitalized

patients, delivered over 13,500 babies and had

more than 1.5 million outpatient visits coming from

Dallas, North Texas and other parts of the world.

All of this could be traced back to an unshakable

and clear vision of quality by the Foundation’s

founder, Dr. Edward H. Cary.

1943 Southwestern Medical College on Oak Lawn

1999 The North Campus

T



1 9 9 9

UT Southwestern faculty elected to the National Academy of Sciences in the 1990s

A. James Hudspeth, MD, PhD

1991

Steven L. McKnight, PhD

1992

Ellen S. Vitetta, PhD

1994

Johann Deisenhofer, PhD

1997

David L. Garbers, PhD

1993

13

23

1999 numbers are shown relative to 2015.* National Academy of Sciences

3.6 M$500 M1,100 42,300

7.7 M$2.3 B2,400 64,700

TotalSq. Ft.

Annual Budget

Full-Time Faculty

NAS*Members

Nobel Laureates

TotalStudents

1999 vs. 2015

Future issues of Perspectives magazine willfollow the history of the Foundation from 2000 on. The North

Campus continues its expansion; more Nobel Laureatesare named; and the medical center, supported in part by gifts

made through the Foundation, completes thestate-of-the-art William P. Clements Jr. University Hospital.

[ CONT. ]

A GRAND CELEBRATION OF A GRAND VISION

68

SEVENTY-FIVE years ago, Southwestern Medical Foundation was formed by leaders who knew that a great city would require great philanthropy. In recognition of this diamond anniversary, the Foundation held a celebration at the Winspear Opera House to honor the many visionaries whose generous contributionsover the years have led to extraordinary advancements in medical research, medical education and health care.

We hope you enjoy a pictorial review of what was a wonderful evening of celebration.

PHOTOGRAPHY BY STEVE FOXALL AND DAVID GRESHAM

'' DALLAS in the early days was basically a medical wilderness,

not having libraries or laboratories or pathologists in the city when my grandfather

came to Dallas to start his practice in 1902 – there was none of that here.” Edward H. Cary, III

HONORARYCo-Chairs of the Foundation’s 75th Anniversary

Steering Committee were Mayor Mike Rawlings and Mr. and Mrs. Peter

O’Donnell, Jr. William T. Solomon served as Chairman.

COMM ITTEE members included Edward H.

Cary, III – the grandson of Foundation founder Dr. Edward H. Cary –

Ruth Collins Altshuler, Jan Hart Black, Mary McDermott Cook,

David R. Corrigan, Harlan R. Crow, Thomas M. Dunning, Robert A.

Estrada, Nancy Strauss Halbreich, Paul W. Harris, Lyda Hill,

James R. Huffines, Mrs. Eugene McDermott, Dr. Daniel K. Podolsky,

Caren H. Prothro, Carolyn Perot Rathjen, Catherine M. Rose,

Lizzie Horchow Routman, Robert B. Rowling and Emmitt J. Smith, III.

71

“It was the Foundation that stepped up and said we’ve got to be a provider, a catalyst.”

Mayor Mike Rawlings

“We’ve got just the brightest people –this is a real shining star.”

Caren Prothro

“Six Nobel Laureates – my gosh a’mighty – nobody has all that!”

Lyda Hill

“Southwestern Medical Foundation is in large part responsible for the enormous success

of Dallas as a medical center.”Ruth Altshuler

“You can’t be a world-class city such as Dallas is today without a teaching hospital and a

medical center of the quality that we have.”Harlan Crow

“Research drives the evolution and development of health care and medicine.”

Bill Solomon

“There were a few key people like Don Seldin whosaid this institution is going to stand

for excellence. It will grow for sure – it will do all the things that it has to do, but as it does,

it will stand for quality. That was part of the founding and the culture of the institution,

and it persisted through the decades.”Kern Wildenthal, MD, PhD

“As we know, medical scientific research begins with the individuals who are trained and dedicated to doing that research and have the

resources available to them to carry out that research.That’s what’s been so vital

about Southwestern Medical Foundation.”Bob Estrada

“Without the generosity of the people of thiscommunity, UT Southwestern would not be one of

the top-rated medical schools in America.”Senator Kay Bailey Hutchison

“Curiosity. What would the medical school be without curious people?”

Margaret McDermott

“I feel very strongly that people in academic clinical departments should, among other things,

have a research program of presumably high dignity.”Donald Seldin, MD

“Sometimes I’m in the position of just dreaming about doing excellent research. Because of

Southwestern Medical Foundation, it’s been possible to actually achieve what I want to.”

Bruce Beutler, MD, Nobel Laureate

“We’re gonna build a medical school – we’re gonna build a great medical school.”

Tom Dunning

“You have to give them the opportunity to make their discoveries. You have to make it

possible so that they know that they won’t be limited – that they’re limited only

by their imagination and skill.”Michael Brown, MD, Nobel Laureate

74

'' THE MEDICAL CENTER was not a creation of the city, but of the citizens of Dallas seeing a need for their community.”

Dr. Daniel K. PodolskyPresident UT Southwestern

During the gala, the Foundation announced a $7.5 million gift to UT Southwestern to provide support

and inspire additional gifts to accelerate scientific discovery and strengthen its standing as a leader in neuroscience.

'' WE ARE lastingly grateful to the founders, donors and all the other past and

present visionaries who have made such an impact on our community.”

Kathleen Gibson

GALAGALLERY

To view more photos, go to swmedical.org > Events.

78

33 Years of Wisdom WILLIAM T. SOLOMON SERVED NOBLY AS FOUNDATION CHAIR

SOUTHWESTERN MEDICAL FOUNDATION MILESTONE

Bill Solomon began his service on the Board of Trustees of Southwestern

Medical Foundation in 1981. He became Chairman of the Board in 2008 and led the Foundation during six years of transition and growth. When the Heritage Society was formed in 1995, Solomon and his

wife, Gay, became Charter Members. During 2000, when the quiet phase of the largest campaign in the medical school’s history was announced, Sol-omon organized and led a committee of 100 civic and business leaders and stepped up as Chair of the Innovations

in Medicine campaign – an eight-year campaign that began with a goal of $500 million and ultimately raised $772 million. The Solomons committed a lead gift of $1 million to the campaign. Then in 2003, they added $10 million to endow enhanced patient services and to create the William T. and Gay F. Solomon Division of General Internal Medicine at UT Southwestern. The intent of the gift was to help perfect a seamless system of clinical care, combining patient services with the latest technology and physician expertise. The ultimate goal was lofty: to create a model for improved doctor-patient relations in Dallas and other environments around the country. During 2004, the Solomons received the Foundation’s highest volunteer

service honor: the Charles Cameron Sprague Community Service Award. During 2011, the Building the Future

of Medicine campaign was announced and, again, Solomon stepped up to leadthe effort to raise $200 million in com-munity support for the $800 million William P. Clements Jr. University Hospital. That same year, the Solomons gave $1 million in support of the new, state-of-the-art hospital. The Solomons have made an extraordinary impact on the Foundation

80

In honor of Bill Solomon’s lasting

contributions over 33 years,

Southwestern Medical Foundation

created an endowed Professorship:

the William T. Solomon Professor-

ship for Quality in Clinical Care.

It is meant to recognize and

sustain in perpetuity the lead-

ership Solomon has brought to

patient-centered, humanistic and

quality care at UT Southwestern –

and to further embed quality

practices in health care in Dallas

and throughout the world.

and UT Southwestern, serving with tremendous distinction for more than 30 years. With the exception of the founders, no one has since made a greater contribution in leadership, governance, and rallying of community support for Southwestern Medical Foundation than Bill Solomon. We are tremendously grateful and will be forever appreciative of his years of leadership and his depth of wisdom and generosity.

Kathleen Gibson, Bill Solomon and Bob Rowling with the framed tribute of the William T. Solomon Professorship for Quality in Clinical Care.

“It has been remarkable for me to contemplate the enormous impact that Bill and Gay Solomon have

made on the Foundation and UT Southwestern.”

Robert B. Rowling Chairman of the Foundation

“He has served not just as the right leader at the right time but as the counselor to many at the Foundation

and medical center on every important matter they have faced since he became Chair in 2008.”

Dr. Daniel K. Podolsky President, UT Southwestern

Bill Solomon

A Legacy of Giving“We only hope that through the years many of our citizens will remember

the Foundation in order that human suffering can be alleviated.”

– Karl Hoblitzelle, Founder

Mary Lucile Shannon

Throughout Southwestern Medical Foundation’s history, its impact has been enhanced by generous lifetime and estate gifts. To all who have made these gifts, we owe a debt of gratitude for their concern for quality health care and a vision that medical research could help improve the lives of everyone in our community and throughout the world.

BY RANDAL DAUGHERTY

82

Fifty years after her husband, Dr. Hall Shannon, became one of the key architects

of the founding of Southwestern Medical Foundation in 1939, and 21 years after his death

in 1968, Mary Lucile Shannon bequeathed to Southwestern Medical Foundation almost

$4 million to create the Hall and Mary Lucile Shannon Distinguished Chair in Surgery

at UT Southwestern. Since its establishment, this Chair traditionally has been held by

the Chairman of the Department of Surgery, raising the Department’s prominence and

attracting renowned physicians to the medical center.

The first person to hold the Shannon Chair was one of the leading surgery chiefs and

trauma experts in the country, Dr. C. James Carrico. The Shannon Chair was instrumental

in his decision to return to his alma mater in 1990, where he had received the highest honor

a senior medical student can receive, the Ho Din Award. Today, this prestigious Chair

resides with the internationally acclaimed surgical oncologist Dr. Michael Choti, the current

Chairman of the Department of Surgery and the Surgeon-in-Chief for William P. Clements

Jr. University Hospital.

Mary Lucile, or “Cile” as she was known, was involved in civic work that

complemented the work of her husband, a well-known Dallas surgeon and a member of the

surgical staff at Baylor University Medical Center from 1919 until his retirement in 1959.

Mrs. Shannon served as president of the Dallas County Medical Society Auxiliary and as an

organizer of the Visiting Nurse Association.

Upon his appointment to the Shannon Chair, Dr. Carrico said, “An Endowed Chair

is a graphic and solid demonstration of UT Southwestern’s dedication to the surgery

program.” It is also a lasting legacy of the generosity of Mrs. Shannon and a wonderful

memorial to the many contributions she and Dr. Shannon made in building health care in

this community.

In 1996, a $5 million bequest from Virginia Murchison Linthicum became one of the first

gifts to UT Southwestern’s Endowed Scholars Program in Medical Science, which supports

tenure-track assistant professors to pursue research in both basic and clinical science. Almost

20 years later, the program has launched the careers of 76 investigators, among them 12 who

carried the title of Virginia Murchison Linthicum Scholar in Medical Research.

Mrs. Linthicum, in her lifetime and through her estate, built a tremendous legacy of

generosity at UT Southwestern. Nearly a decade before her death, she created the Virginia

and Edward Linthicum Distinguished Chair in Biomolecular Science.

As a young woman, she married Clint Murchison, Sr., an avid sportsman. They traveled

to ranches they owned and welcomed such guests as the Duke and Duchess of Windsor and

President and Mrs. Lyndon Johnson. After Mr. Murchison’s death, she married Edward

Linthicum, an importer and breeder of Arabian horses, a cattle rancher and an oil investor.

In the early 1980s Mr. Linthicum was treated for leukemia at UT Southwestern. The

Linthicums were so impressed by the outstanding quality of care he received that they decided

to offer ongoing financial support, most notably through this wonderful bequest through

Southwestern Medical Foundation.

Virginia Murchison Linthicum

Browns’ combined estates to be used for scientific research in the causes, pre-vention, treatment and/or cure of heart ailments, cancer and/or mental illnesses and in the medical applications for and against these diseases.

Ruby D. Hexter Charitable Trust$1 million. Trust principal was transferred to Southwestern Medical Foundation as an endowment to benefit projects of interest to Dr. Seldin. Mrs. Hexter was a patient of Dr. Seldin’s.

Helen L. Wineburgh $10,000 for ful-fillment of the mission of Southwestern Medical Foundation.

1 9 8 8George A. Wilson $300,000 for fulfill-ment of the mission of Southwestern Medical Foundation.

Lorraine Sanders $20,000 to benefit Children’s Medical Center.

1 9 8 9Mary Lucile Shannon $3.7 million to create the Hall and Mary Lucile Shannon Distinguished Chair in Surgery.

1 9 9 0Josephine Simonson $73,500 to expand assistance to victims of aphasia – the loss or impairment of the ability to communicate, usually resulting from an injury or stroke. Ms. Simonson was a nationally recognized teacher and clinician in the field of pathology and a member of the Department of Neurology at UT Southwestern.

Dr. Frank H. Kidd, Jr. $10,000 for emergency student loans.

1 9 8 0Nina Beeks Super $10,000 to establish the Dr. Archie R. Super Scholarship Fund.

1 9 8 5Ella C. McFadden $4 million from a charitable trust Mrs. McFadden estab-lished in her will to terminate in 20 years. Following her death in 1965, an endowment was established to support the Bio-Behavioral Brain Science program in the Department of Psychiatry at UT Southwestern.

1 9 8 6Mary Olive Titterington McClendon $1.045 million from a testamentary trust provided in her will. The trust provides that the distribution be designated a “Gift from Mary Olive Titterington McClendon and Robert Williamson McClendon to be used for scientific and medical research for illnesses of the mind and body.”

Pinta Huff Harris $1.5 million repre-senting one-half of her residuary estate to be used in the State of Texas for medical and scientific research in the prevention, treatment and cure of cancer or mental illness.

1 9 8 7Ida Green $465,000 representing 3 per-cent of her residuary estate. Funds were used to establish the Ida Green Fund.

Ralph E. Brown and Berniece R. Brown Approximately $1.5 million from the

Bequests in the 1980s and 1990s to Southwestern Medical Foundation

1 9 9 2Wilma Sprague Stewart $800,000. She was the sister of Dr. Charles Sprague.

Dr. William E. Crow $630,000 from the termination of the trust Dr. Crow created in his will to provide for his wife, Fannie Davis Crow, and longtime nurse, Frieda Smasal. His wife died in 1970 and left a bequest of $431,000. The funds support important research projects.

Pauline Wallace $85,000 to create the Pauline Wallace Memorial Endowment Fund, used to support Alzheimer’s disease research at UT Southwestern.

1 9 9 3Dr. Everett C. Fox $400,000 bequest to be used for lectureships, teaching and research in the Department of Dermatology at UT Southwestern.

1 9 9 4May E. Sanders $50,000 to the Harold B. and May E. Sanders Scholarship Fund.

Ralph E. Hays Family Trust $60,000 for fulfillment of the mission of Southwestern Medical Foundation.

William C. Chilton $10,000 for fulfill-ment of the mission of Southwestern Medical Foundation.

1 9 9 6Louise Kahn $1 million directed to support the Endowed Scholars Program.

1 9 9 8Virginia Murchison Linthicum $5 million earmarked for the Endowed Scholars Program.


What’s Next?ORIGINAL LECTURE SERIES

84

TWO INSPIRED CONVERSATIONS: ONE LOOKING FORWARD, ONE LOOKING BACK

On April 7, 2014, in the Pecan Room at Old Parkland, Southwestern Medical Foundation held its second “Leading the Conversation on Health” program. These conversations are designed to bring together a diverse community of thought leaders focused on the future of health and provide a means to better understand the

SECOND ROW – Lee Cullum, Dr. Joe Goldstein, Dr. Bruce Beutler, Lyda Hill, Jack Roach, Dr. Daniel K. Podolsky, Harlan Crow, Dr. Joe Goldstein, Gay Solomon, Peter O’Donnell, Elvis Mason, Lyda Hill, Terry and Bob Rowling

PHOTOS BY STEVE FOXALL


SECOND ROW – Harlan Crow; Don Zale, Kathleen Gibson

THIRD ROW – Bill Solomon, Kathleen Gibson, Peter O’Donnell; Tom Dunning

FOURTH ROW – Peter and Bonnie Smith, Phillip Wiggins; Dr. Carol Podolsky, Dr. Daniel K. Podolsky, Trinka Taylor

extraordinary strides being made in academic medicine, education and clinical care in the Dallas area. The event was hosted by Bill Solomon, Kathleen Gibson, and Harlan Crow, whose Crow Holdings restored the Parkland Hospital and Nurses Quarters. Old Parkland was the original teaching hospital for Southwestern Medical College, which was started by the Foundation on the Old Parkland Campus. We were fortunate to have a conversation with Nobel Laureates Bruce Beutler, MD, and Joseph Goldstein, MD. Dr. Goldstein is Chair of Molecular Genetics at UT Southwestern, and Dr. Beutler is Director of the Center for the Genetics of Host Defense. Introductions were made by Dr. Daniel K. Podolsky,and the event was moderated by Lee Cullum. Our speakers riveted the crowd with stories of breakthroughs in science, inspiring outstanding questions from the audience.

On November 24, 2014, filmmaker, journalist and broadcaster Quin Mathews screened a series of film clips titled “How Dallas Brought a Great Dream to Reality,” marking the third “Leading the Conversation on Health” event. “One of the most remarkable stories in Dallas history is the unique way in which the Foundation came together to create one of the leading medical research centers in the world,” said Mathews. “As the Foundation celebrates its 75th anniversary, we are indebted to the donors and founders whose vision and generosity have indeed advanced the goal of building one of the finest medical centers anywhere,” said Foundation President Kathleen Gibson. Guests in attendance included Foundation founder grandson Edward H. Cary, III, Honorary 75th Steering Committee Chairs Edith and Peter O’Donnell, 75th Steering Committee Chairman Bill Solomon, Foundation Chairman Bob Rowling, and Foundation Board members Sara Albert, Jill Bee, Gil Besing, Dan Branch, Harlan Crow, Bob Dedman, Tom Dunning, Bob Estrada, Jeff Heller, James Huffines, Dr. Daniel K. Podolsky, Linda Robuck, George Seay, Trinka Taylor, Dr. Kern Wildenthal, Dr. Kneeland Youngblood and Don Zale.

Edith O’Donnell, Quin Mathews

Annual MeetingSOUTHWESTERN MEDICAL FOUNDATION

ROBERT B. ROWLINGAPPOINTED CHAIRMANAND 2014-2015 TRUSTEES NAMED

t its annual meeting, Southwestern Medical Foundation announced that Robert B. Rowling has been appointed Chairman of the Foundation. In his new role, Rowling will work closely with Foundation President and CEO Kathleen Gibson. Rowling previously served on the Foundation’s Executive Committee and as Vice Chairman of the Board. He replaces William T. Solomon, who is stepping down after serving as Chairman since 2008. The announcement comes as Southwestern Medical Foundation marks its 75th anniversary of advancing the cause of academic medicine, innovative research and leading-edge medical education. “As we celebrate our remarkable history in this mile-stone year, we are extremely fortunate to have Bob Rowling providing new leadership on the Board and helping expand the Foundation’s position in the business, philanthropic, and medical communities,” Solomon said. “In addition to his broad business, management and financial experience, he brings a strong understanding of the community and the donors who are served by the Foundation.” Rowling is owner and chairman of TRT Holdings, Inc., a company with global interests in energy, hotels, financial services, fitness and consumer retailing. He previously served as Vice Chairman of the UT System Board of Re-gents and as Chairman of the UT Investment Management Company. In 2003, Rowling was inducted into the Texas Business Hall of Fame, and in 2005, he was inducted into both the UT Austin McCombs School of Business Hall of Fame and the All-American Wildcatters for his achievements in the oil and gas industry. In November 2013, he was honored by his alma mater with the university’s highest distinction as he joined the ranks of UT’s Distinguished Alumni. Rowling and his wife, Terry, have given generously to numerous organizations in Dallas and around the world. In November, the Rowlings were recipients of the 2013 Charles Cameron Sprague Community Service Award, the Foundation’s highest community distinction, honoring those who provide significant support to the improvement

86

A of medical education, medical research and patient care. Their most recent gift to UT Southwestern totaled $5 million to assist in support of the new William P. Clements Jr. University Hospital. “It is a pleasure and an honor to help Southwestern Medical Foundation continue to play a pivotal role in supporting world-class patient care, scientific innova-tion and education for the next generation of health care professionals,” Rowling said. “Thanks to the foresight of so many visionary men and women, the Foundation has built

a meaningful 75-year legacy in our community. I look forward to working with our dedicated trustees and generous donors to build on that legacy. “I would also like to thank and acknowledge the tremendous leadership of Bill Solomon, who contin-ues to serve on the Founda-tion Board, and who chairs

the 75th Anniversary Steering Committee. We owe Bill a great debt of gratitude for the work and preeminence the Foundation has achieved under his insightful leadership.” Rowling’s appointment comes during a period of extraordinary growth for UT Southwestern. In the last few decades, the medical center has made a rapid rise to prominence and emerged among the top tier of research and clinical institutions in the world. “We are thrilled to announce Bob Rowling as Chair-man during this exciting period for Southwestern Medical Foundation,” Gibson said. “He is an extraordinary busi-nessman with profound insight into our community. He will play a major role as the Foundation continues its support for one of the world’s preeminent medical centers. Thanks to Bob’s expert guidance, the Board and the Foundation will continue to positively impact the future of health and the achievement of important medical breakthroughs.”

Robert B. Rowling, new Chairman of the Foundation

ROBERT B. ROWLINGAPPOINTED CHAIRMANAND 2014-2015 TRUSTEES NAMED

“Thanks to Bob’s expert guidance, the Board and the Foundation will continue

to positively impact the future of health and the

achievement of important medical breakthroughs.”

Kathleen M. Gibson


FIRST ROWRolf Haberecht, Bill Solomon, Leonard Riggs

SECOND ROWDr. Daniel K. Podolsky, Senator Kay Bailey Hutchison, Mike Myers, Linda Hart, Mitch Hart

Bill Solomon, Catherine Rose

Jennifer Eagle, Carolyn Rathjen

THIRD ROW Jere Thompson, Jr., David Haley, Peter Beck

Edward H. Cary, III, Kathleen Gibson, Ed Daniels

John McStay, Ruben Esquivel, Carlos Peña

Andrew Avery, MD, is just the second graduate in the history of UT Southwestern Medical School to win both the Ho Din Award and the Iatros Award. The Ho Din Award was instituted by Southwestern Medical Foundation in honor of Dr. E. H. Cary to recognize those who exemplify the unique personal qualities embodied in all great physicians – knowledge, understanding, and, most of all, compassion. Ho Din, which represents “the spirit of medical wisdom and human understanding,” has been a hallmark of excellence at UT Southwestern for more than 70 years and is the foremost honor bestowed on outstanding seniors. The Iatros Award, first presented in 1984, is sponsored by the UT Southwestern Medical School Alumni Association and is determined by a vote of the graduating medical class.

Dr. Andrew Avery, winner of the 2014 Ho Din Award, and Edward Cary, III, the grandson of Dr. Edward H. Cary, who established the award in 1943.

SOUTHWESTERN MEDICAL FOUNDATION

Listed below are the 14

new Trustees of Southwestern

Medical Foundation elected

for the 2015-2016 year.

Their photos and bios will

appear in the next issue.

Charles Anderson

Leland R. Burk

Richard W. Fisher

Dr. Marshal D. Goldberg

J. Hale Hoak

Dr. Richard E. Hoffman

Gary C. Kelly

Samuel D. Loughlin

Bobby B. Lyle

S. Todd Maclin

Dr. Lee Ann Pearse

Steven S. Schiff

Lisa Troutt

Kelcy L. Warren

Jennifer Eagle

A Dallas native, Jennifer Eagle

is an active volunteer dedicated

to the local community. She

attended Woodrow Wilson High

School and earned her BBA from

Baylor University. Currently, she

is a Board Member of TACA,

where she has served on the

Finance Committee, Profile and

Brand Management Commit-

tee, Grants Committee and as

Board Chairman. Jennifer is also

a Board Member of the Dallas

Zoological Society and serves on

its Executive Committee, Nomi-

nating Committee, and as Capital

Campaign Committee Co-Chair

in addition to serving as Devel-

opment Committee Co-Chair for

the past five years. Previously, she

served on the Board of the Dallas

Children’s Advocacy Center and

the President’s Advisory Council

for the AT&T Performing Arts

Center and Co-Chaired 2x2 for

Aids and Art.

Together with her husband

John, Jennifer was honored with

the S.M. Wright Foundation

Appreciation Award in 2009 and

the Episcopal School of Dallas

Philanthropy Award in 2006.

Stuart Fitts

Stuart Fitts is the Managing Part-

ner of Fitts Investment Company,

a Dallas-based privately held

investment firm with investments

in a diverse field of interests

including golf course develop-

ment, oil and gas, commercial

real estate, pharmaceuticals and

medical technology.

Stuart is also the Managing

Partner of West Dallas Invest-

ments and Trinity Groves, a real

estate partnership focused on

the assemblage and development

of property in the West Dallas

area of the Trinity River corridor.

Trinity Groves is a restaurant

incubator that has created dozens

of new restaurant concepts.

Stuart previously owned EGF

Broadcast Corporation and Gulf

California Broadcast Company,

which owned and operated radio

and television properties in Palm

Springs, California.

In 2006, he co-founded and

became Managing Partner of

Scientific Health Development,

an investment fund focused on

early stage medical device and

pharmaceutical companies. He is

also co-owner of EBG, LLC, the

holding company that owns and

operates Eatzi’s Market & Bakery

in Dallas.

Stuart is the author of a chil-

dren’s book on safety: A Stranger

in the Park. The book is used by

educators, police and security

officials as an education tool to in-

struct parents and children about

the threat of “stranger danger”

in a nonthreatening but effective

manner.

Stuart is a native Dallasite. He

received his BA in English from

Southern Methodist University in

1987 and his MBA from SMU's

Cox School of Business in 1991.

Governor George W. Bush

appointed Stuart to the Texas

Diabetes Council in 1995. He

served two terms on the Council

and was responsible for creating

the Mobile Diabetes Care Unit

program. He has served on the

Board of Presbyterian Healthcare

Resources and Hunger Busters, a

nonprofit organization dedicated

to feeding the homeless. He also

served on the Board of the

Ronald McDonald House of

Dallas.

New TrusteesFOR 2014-2015FOR 2015-2016

88

Kathryn W. HallU. S. Ambassador ( ret.)

Kathryn Hall is the proprietor of

HALL Wines and WALT Wines

and has been involved in the

California wine industry since her

family first purchased a vineyard

30 years ago. She has had a dis-

tinguished career as a successful

businesswoman, as a community

activist, and most recently as the

U.S. Ambassador to Austria.

Kathryn began her public

career as assistant city attorney

in Berkeley, California. Later, she

joined Safeway Stores, where she

was responsible for developing

and administering one of the na-

tion’s first and largest affirmative

action programs. Subsequently

she worked as an attorney and

businesswoman in Dallas, where

she was President of an inner city

development company and part-

ner of Hall Financial Group, Inc.

Long committed to social

issues, Kathryn has served on

numerous nonprofit and institu-

tional Boards, addressing issues

related to social care and mental

health. She co-founded the North

Texas Food Bank, served on the

U.S. House of Representatives

Hunger Advisory Committee, and

was the Director and VP of the

Texas Mental Health Associa-

tion. Kathryn has served on the

National Advisory Council for

Violence Against Women and as

a trustee of the Woodrow Wilson

International Center for Scholars.

She served as the U.S. Am-

bassador to Austria from 1997 to

July 2001. During her term, she

worked hard to promote Ameri-

can wine in Austria and Europe.

Since her return to America, she

has resumed her role as proprietor

of Kathryn Hall Vineyards. Based

upon her experience promoting

American agriculture in Austria,

in September 2001 she was

appointed to the United States

Department of Agriculture’s

Agricultural Technical Advisory

Committee (ATAC) for interna-

tional trade.

Kathryn earned a BA in

Economics from the University

of California, Berkeley, and a JD

from the University of California

Hastings College of Law.

Dr. Chris MillerPresident, Dallas County Dental Society

Dr. Chris Miller and his brother,

Dr. Matt Miller, have spent more

than two decades together in

dentistry and co-founded Miller

& Miller, DDS, which has served

patients in the Plano area since

1986.

Chris volunteers with Christi-

na’s Smile, a nonprofit organiza-

tion that provides free dental care

to children in need. He also pro-

vides services for an organization

known as the Lost Boys of Sudan.

In 2001, the International Rescue

Committee rescued 3,800 “Lost

Boys” from Sudan and placed

them in approximately 100 cities

around the United States. Before

being brought to America, these

young men were forced to flee

from their native Sudan at a very

young age and walk hundreds of

miles in an attempt to survive the

civil war in Sudan. Many of these

young men had five or six of their

bottom front teeth extracted in

tribal ceremonies, and they are

now struggling to eat American

food and speak English properly.

Chris is a 1980 graduate

of the University of Kansas with

a BA degree in Human Biology.

He attended Baylor College of

Dentistry in Dallas and received

a Doctor of Dental Surgery

(DDS) degree in 1984. He is

an active member of, and has

held leadership positions in, the

American Dental Association,

the Texas Dental Association, the

Academy of General Dentistry,

and the Dallas County Dental

Society. Chris is also an alumnus

of the prestigious L.D. Pankey

Institute.

Ray Nixon, Jr.

Ray Nixon is the Executive

Director and Portfolio Manager

of Barrow, Hanley, Mewhinney

& Strauss, LLC. Barrow Hanley,

founded in 1979, is one of the

largest value-oriented investment

managers of institutional assets

in the U.S. The $96 billion dollar

firm provides value-oriented

investment strategies to institu-

tional investors, mutual funds, and

family offices on five continents.

Ray joined Barrow Hanley in

1994 from Smith Barney, Inc.,

where he was a member of the

firm’s Investment Policy Com-

mittee and served as the lead

institutional stockbroker for the

Southwest. During his 37-year

investment career, he also served

as a research analyst for the Teach-

er Retirement System of Texas.

Ray holds a BA and an MBA from

The University of Texas.

(cont. on next page)


SOUTHWESTERN MEDICAL FOUNDATION

New Trustees

FOR 2014-2015 (cont.)

Ray is Chairman of

the Texas Health Resources

Investment Committee and a

member of the McCombs School

of Business Advisory Council, The

University of Texas Development

Board, and the Board of the

Salvation Army.

James C. Oberwetter U. S. Ambassador (ret.)

James Oberwetter is a Dallas

executive with extensive senior

leadership experience in the non-

profit, government and business

sectors.

In April of 2014 he retired as

President and CEO of the Dallas

Regional Chamber of Commerce,

where he served since 2009.

During his tenure, the Chamber’s

economic and strategic devel-

opment fund tripled in size, and

significant corporate recruitment

to the region was the result.

In November 2003 he was

nominated by President George

W. Bush to serve as U.S. Ambassa-

dor to the Kingdom of Saudi Ara-

bia. Following his confirmation,

from February 2004 until April

of 2007, he used his public policy

and business management skills

to lead his country team in a

repositioning of the U.S./Saudi

relationship.

Prior to his Ambassadorial

service, James was Senior Vice

President of Hunt Consolidated,

Inc. of Dallas, where he advised

the Chairman, Ray L. Hunt, and

the Hunt family of companies,

including Hunt Oil Company, on

governmental and public affairs

strategies domestically and inter-

nationally.

His past civic service includes:

Chairman, Texas Commission on

Drug and Alcohol Abuse; Chair-

man, City of Dallas Civil Service

Commission; Chairman, biparti-

san City of Dallas Redistricting

Committee; Executive Commit-

tee, Dallas Metropolitan YMCA;

Chairman, Volunteer Center;

Vice Chairman, Dallas Fort

Worth World Affairs Council;

founding member, Dallas Friday

Group and the Dallas Breakfast

Group; member, Board of Dallas

Workforce Commission; member,

Board of the Greenhill School;

honorary Lifetime Achievement

Award from the Texas Parent

Teacher Association for leading

groups in peaceful desegregation

of the Dallas school system. He

was nominated for the U.S. De-

partment of State’s Cobb Award

for outstanding Ambassador of

the year.

Prior to his work with Hunt,

James served as press secretary to

then Congressman George H. W.

Bush and as special assistant to

the Administrator of the U.S. En-

vironmental Protection Agency.

James was educated at The

University of Texas at Austin,

graduating with a Bachelor of

Journalism degree from the

School of Communications.

Bob Schlegel

Bob Schlegel grew up near Toron-

to, Canada, where he graduated

with a BA in Economics and a

CPA license from Wilfrid Laurier

University. In 1979 he started two

companies in Dallas and in 1985

moved his family here. He and his

wife, Myrna, built and operated

a group of luxury nursing and

retirement centers with 2,500

beds in 15 locations. He also

built Pavestone Company into a

national manufacturer of concrete

landscape products with 20 manu-

facturing locations.

Bob and Myrna have been

recognized by WLU with Honor-

ary Doctorate degrees and a new

facility named in their honor, The

Schlegel Centre for Entrepreneur-

ship and Innovation. Bob was in-

ducted into the Horatio Alger As-

sociation in 2008. Some of Bob’s

favorite volunteer positions have

included serving on the Executive

Board of the SMU Cox School of

Business and on the Boards of the

Students in Free Enterprise, the

Salvation Army and the Young

Presidents’ Organization.

With his son, Kirby, Bob

owned and operated the Texas

Tornado Junior-A Hockey Team

of the NAHL; the Iowa Stars, a

former AHL farm team for the

Dallas Stars; and the Tacoma

Rainiers Baseball Club, the

Triple-A affiliate of the Seattle

Mariners.

Deborah Engstrom Scripps

Debbie Scripps has been a dedi-

cated community volunteer since

she and her husband, Ric, moved

back to Dallas from Minnesota in

1980. Debbie attended Thomas

Jefferson High School in Dallas

and Drake University in Des

Moines, Iowa. After graduating

with her Bachelor of Science in

Education, she worked as a grade

90

school teacher for several years.

Upon returning to Dallas, she

immediately became a hands-on

community volunteer. Currently,

she serves on the Executive

Committee of Children’s Medical

Center Foundation, as a member

of Crystal Charity Ball, and as

an Advisory Board Member for

Texas Community Partners. In

addition, Debbie has served in

many leadership roles, including

as President of the Junior League

of Dallas, as Chair of Children’s

Medical Foundation Board of

Trustees, and as a member of

the Bryan’s House Board of

Directors. Her previous Board

positions include the Volunteer

Center of Greater Dallas and the

Mental Health Association of

Greater Dallas.

Nicole G. Small

Nicole Small serves as CEO of

LH Holdings, Inc. and as Presi-

dent of the Lyda Hill Foundation,

related entities that use their

resources to fund game-changing

advances in science and nature,

empower nonprofits, and improve

the local communities of greatest

importance to the organizations’

founder, Miss Lyda Hill. In these

roles since early 2014, Nicole is

responsible for overseeing the

strategic direction of both enti-

ties, including their

financial and investment activi-

ties, as well as their philanthropic

initiatives.

From 2011 through 2013,

Nicole served as the inaugural

Eugene McDermott CEO of

Dallas’ Perot Museum of Nature

and Science. Nicole joined

the Dallas Museum of Natural

History in 2001, having first served

as a member of the Museum’s

expansion team until she was

named CEO in April 2002.

In 2006, Nicole spearheaded

the merger of the city’s three

then-existing nature, science, and

children’s museums (the Dallas

Museum of Natural History, The

Science Place and the Children’s

Museum) into a single museum

that later became the Perot

Museum of Nature and Science

in Victory Park. Nicole worked

with the Board, the community

and the Museum team to raise

more than $200 million, which

provided for the site acquisition,

exhibition planning and design,

construction of the new

building, education programs and

an endowment – more than a full

year before the Museum’s

planned opening. These

achievements earned the Perot

Museum widespread acclaim,

both for its innovative design and

programming excellence.

Earlier, Nicole held positions

with several technology, venture

capital and consulting firms,

including serving as the founder

and CEO of an Internet start-up,

as an entrepreneur in residence

at a California-based business

incubator, and as an analyst with

McKinsey & Company.

Nicole received an undergrad-

uate degree from the University of

Pennsylvania and an MBA from

the Kellogg School of Manage-

ment at Northwestern University.

She is currently a member of the

Dallas Assembly, YPO, Charter

100, and International Women’s

Forum. She serves on the Boards

of the A.H. Belo Corporation and

Communities Foundation of Tex-

as and on the Strategic Planning

Committee for The Hockaday

School.

Jim Walton, MDPresident, Dallas County

Medical Society

Dr. Jim Walton is President

and CEO of Genesis Physicians

Group, the largest independent

physicians association in North

Texas. A former practicing

internist, Jim served as Vice

President of Network Perfor-

mance/Baylor Quality Alliance at

Baylor Health Care System before

joining Genesis in March.

Throughout his career,

Jim has been focused on quality

improvement strategies to elimi-

nate health disparities. He brings

together his knowledge of quality

improvement and an understand-

ing of the challenges facing

today’s independent

physicians. He has served as Dallas

County Medical Society’s Medical

Director for Project Access

Dallas, a network of more than

2,000 physicians and 15 hospitals

providing comprehensive

health care access to uninsured

patients in Dallas County.

Jim received an MBA from

the University of Michigan, a

Doctorate of Osteopathic Medi-

cine from the University of North

Texas Health Science Center,

and a bachelor’s degree from

the University of North Texas.

He is board certified in Internal

Medicine.


SOUTHWESTERN MEDICAL FOUNDATION BRINGS TOGETHER FUTURE DOCTORS AND THEIR BENEFACTORS AT ANNUAL SCHOLARSHIP LUNCHEON

Southwestern Medical Foundation

brought together future doctors and the

donors whose gifts are supporting their

medical education at the recent Scholarship

Luncheon held at UT Southwestern’s

T. Boone Pickens Biomedical Building.

The Foundation holds the annual

luncheon to thank philanthropists and

introduce them to the deserving medical

students who benefit directly from their

generosity. This year, the Foundation gave

$223,500 in scholarship awards to 177

medical students.

“We thank the donors for their vision in

providing scholarships that will establish

the next generation of leaders in academic

medicine and health care. As the

Foundation celebrates its 75th anniversary,

we are thrilled to mark this milestone by

introducing our generous donors to the

future doctors they are helping through

medical school,” said Foundation President

Kathleen M. Gibson.

For 75 years, Southwestern Medical

Foundation has been an important phil-

anthropic partner supporting deserving

students at UT Southwestern, managing

$12 million in both merit and need-based

scholarship endowment funds.

“Many students at UT Southwestern

depend on the Foundation’s support for

an exemplary medical education. These

critical funds provide the means to

attract the best and brightest students

year in and year out,” said Wes Norred,

UT Southwestern Vice President for

Student and Alumni Affairs.

Guests at the luncheon included not

only donors, students and Foundation

Board members, but also administrators,

physicians and professors from the medical

school. Also in attendance were members

of the Foundation’s Heritage Society, which

is a society that honors those who have

generously included the Foundation or

UT Southwestern in their estate planning.

Robert B. Rowling, Chairman of the Board

of Southwestern Medical Foundation,

thanked donors for continuing the

Foundation’s 75-year legacy of ensuring

the community support needed for quality

medical education in Dallas.

“Our donors have made a tremendous

92

impact over the last 75 years by helping

thousands of bright young students

complete their medical education,” Rowling

said. “Over 50 percent of all practicing

physicians in North Texas receive some or

all of their training at UT Southwestern.

By helping students, you’re helping the

entire community by investing in the

development of the clinical care that is the

future for all of us.”

During the luncheon, several students

thanked the philanthropists who have

given so generously to support their medical

educations.

“As I was thinking about what to say

today to let you know how much I

TOP – Nia Jones

SECOND ROW – Rachel Hein, Wes Norred, Tyler McDonald; Julie Huang, Camille Herbert, Patricia Beall, Nia Jones

THIRD ROW – Jan Hart Black, Florence Shapiro; Nicholas Norris

appreciate your support, it occurred to me

that this isn’t just about me. Your generosity

is giving back to our community in the

form of better medical care. I am honored

to be the vehicle for that,” said Sachin

Shah, class president for second-year

medical school students.

“As you may be aware, the second year

of medical school with its increased work-

load is difficult to manage sometimes, and

the emotional impact of your assistance

and the sense that there is a community

behind me here at school means a great

deal to me,” said David Willcutts.

“My classmates are some of the most

incredible, intelligent, talented, selfless, and

kind people I have ever come across,” said

first-year student Cami Hebert. “I have

learned more than I ever thought I could

fit in my head, and the mentors who

surround me – upperclassmen, faculty, and

physicians – continually inspire me and

encourage me to be my best.”

Scholarships to UT Southwestern

students have been provided over the

years by many generous donors, families

and friends, from such funds as the: Dr.

E.H. Cary Scholarship Fund; Martha and

Robert Click Scholarship Fund; Frances

B. Conroy Scholarship Fund; Dorothy

R. Cullum Scholarship Fund; Fred F.

Florence Scholarship Fund; Collene C.

and Donald F. Goldman Scholarship

Fund; Felix B. and Josephine I. Goldman

Trust Fund; Jake L. and Nancy B. Hamon

Scholarship Fund; Senator Kay Bailey

Hutchison Scholarship Award for Women

in Science and Medicine; Dr. J. A. Majors

Scholarship Fund; Mr. and Mrs. M. A.

McBee Scholarship Fund; Dr. M. Hill and

Dorothy Metz Scholarship Fund; Morning

Star Family Foundation Scholarship Fund;

Lupe Murchison Foundation Scholarship

Endowment Fund; Tom F. Parker, III,

M.D. Scholarship Fund; Pillow Family

Medical Student Scholarship Fund; Shirley

P. Pollock Scholarship Fund; Kathryn

and Ashley H. Priddy Fund; Ralph B.

Rogers Scholarship Fund; Harold B. and

May E. Sanders Scholarship Fund; Anne

C. Schoellkopf Scholarship Fund; Jay

Simmons Scholarship Fund; Dr. Walter N.

Skinner Scholarship Fund; Dr. Richard M.

Smith Memorial Scholarship Fund; Alayne

and Charles C. Sprague, MD, Scholarship

Fund; S. Edward Sulkin, MD, Scholarship

Fund; Judith R. Tycher Scholarship

Fund; Vanatta Scholarship for Afro-

American Medical Students; Helen and

Juan R. Vilaro-Grau Scholarship Fund;

and Dr. Bryan Williams Medical Student

Scholarship Fund.


This year, Southwestern Medical Foundation has made helping deserving students by lessening the financial burden of receiving an exemplary medical education at UT Southwestern one of its top priorities. With your support, we can help ensure that the next generation of leaders in patient care, biomedical science and disease prevention are well prepared to care for the citizens of Dallas and North Texas. In fact, over 50% of all practicing physicians in the greater Dallas area received some or all of their medical education at UT Southwestern. Almost half of undergraduates depend on scholarship assistance from the Foundation to help them supplement their medical education. Your gift will go to support a combination of financial aid and academic innovation. To make a scholarship donation to Southwestern Medical Foundation in support of these outstanding students, please contact us at 214-351-6143 or visit us at swmedical.org.

TOP – Dr. Greg Fitz, Tyler McDonald

SECOND ROW – Bob Rowling, Kathleen Gibson, Jack Roach; Dr. David Pillow, Sukriti Bansal, Sunny Pillow

THIRD ROW – Kathleen Gibson, Nicholas Norris, Ed Cary,III, Claudia Goodsett,Jan Hart Black; Dr. Gary Reed, Marge Davis, Robert Click

SOUTHWESTERN MEDICAL FOUNDATION CELEBRATES 75 YEARS SUPPORTING LEADING MEDICAL RESEARCH, MEDICAL EDUCATION AND PATIENT CARE

On January 14, 2015, Southwestern

Medical Foundation celebrated its legacy

of advancing medical research, education

and patient care in the community during

a 75th anniversary celebration.

The Foundation announced a $7.5

million gift to UT Southwestern Medical

Center to provide support and inspire

additional gifts to accelerate scientific

discovery and strengthen its standing as a

leader in neuroscience.

“I can think of no more outstanding

example of the spirit of wisdom and hu-

man understanding than the work of the

medical community in Dallas,” said Dallas

Mayor Mike Rawlings, one of several

Honorary Chairs of the 75th Anniversary

Steering Committee.

“We celebrate the impact made by

our founders and the vast contributions

made by our generous community, both of

which have led to extraordinary progress

94

in medicine and will ensure our bright

future,” said Robert B. Rowling, Chairman

of Southwestern Medical Foundation.

“The emergence of UT Southwestern

as one of the nation’s leading biomedical

centers today is a testament to the vision of

the founders and the leaders who came

after them and their commitment to help-

ing the community understand the need,”

said William T. Solomon, Chairman of the

75th Anniversary Steering Committee.

The Foundation’s success coincides

with a period of unprecedented advance-

ments, including the recent opening of

the William P. Clements Jr. University

Hospital.

Equally important is the transformation

of Zale Lipshy University Hospital into a

dedicated neuroscience hospital, with the

intention of “prioritizing neurosciences

from the most basic aspects of research

right down to innovations and delivery

of care today,” as noted by Dr. Daniel K.

Podolsky, President of UT Southwestern.

“This wonderful gift that Southwestern

Medical Foundation is making on the

occasion of its 75th Anniversary symbol-

izes the continued advancement of leader-

ship in science, education and treatment

that Southwestern Medical Foundation

has always represented.”

“As we celebrate the 75th anniversary

of Southwestern Medical Foundation, we

reflect on the profound ways in which our

community has supported building one of

the leading medical centers in the world.

We are lastingly grateful to the founders,

donors and all the other past and present

visionaries who have made such an impact

on our community,” said Kathleen Gibson,

President of Southwestern Medical

Foundation. “Our most recent gift to UT

Southwestern is just one small part of a 75-

year legacy that has been the lasting gift of

Southwestern Medical Foundation.” Huda Y. Zoghbi, MD, PhD

HUDA Y. ZOGHBI, MD, PHD, SELECTED AS THE IDA M. GREEN DISTINGUISHED VISITING PROFESSOR FOR 2015

E stablished by Southwestern Medical

Foundation, the Ida M. Green Distin-

guished Visiting Professorship is named

for the late wife of Texas Instruments

founder Cecil H. Green. Mrs. Green, who

died in 1986, provided a major bequest to

Southwestern Medical Foundation, which

has provided significant and inspired

support recognizing women in science and

medicine for almost 30 years.

Dr. Huda Y. Zoghbi, is a Professor in

the Departments of Pediatrics, Molecular

and Human Genetics, Neuroscience, and

Neurology at Baylor College of Medicine

in Houston. Dr. Zoghbi initially planned

to become a clinical pediatric neurologist,

but an encounter during her residency

inspired her to change course. She realized

that to pursue effective treatments she

needed to specifically understand what

caused the kinds of devastating neurologi-

cal conditions she had encountered.

Dr. Zoghbi went on to establish her

own lab at Baylor, and later she and her

colleagues identified mutations in the gene

MECP2, which causes the neuro-

developmental disorder Rett syndrome.

Dr. Daniel K. Podolsky is presented with a $7.5 million gift to support leadership in neuroscience at UT Southwestern by Kathleen Gibson, Bill Solomon and Bob Rowling (not pictured).

This annual event is important in working

to inspire women in the biomedical science

and medicine fields. Nothing speaks

louder than to see the successes of other

women and to have role models and spon-

sors emerge for others.”

In a recent article she co-authored with

Dr. Paul Greengard, Nobel Laureate in

Physiology or Medicine (2000), for The

Scientist, Dr. Zoghbi wrote, “We owe it to

ourselves and to the future of U.S. science

to portray the richness that a life in re-

search can hold for both men and women.

We have all seen highly gifted people with

a love of math or science pursue other

lucrative careers, simply because they don’t

realize the excitement that can be found at

the lab bench or in the field.

“The beauty of science is that when

you go to work every day, you have no idea

what might happen. You may work hard

for months or years with little progress

toward answers until the day when

everything changes. The rush of reward

and satisfaction is beyond compare. For

anyone, man or woman, what could be

more exciting than that?”


Standing (left to right ) : Jane Johnson, PhD, Huda Zoghbi, MD, PhD, Diane Jeffries, Jo Ann Carson, PhD, Devon Crawford, PhD, Alecia Nero, MD, Mary Ashley Liu, Laurie Seidel. Sitting ( left to right ) : Christina Ahn, Courtney Lane, Lauren Tyra, Angela Shoup, PhD, Marissa Pullum, Carole Mendelson, PhD, Naomi Winick, MD, Jenny Hsieh, PhD.

Rett, which mainly affects girls, is charac-

terized by normal early growth and devel-

opment followed by a slowing of develop-

ment, loss of purposeful use of the hands,

distinctive hand movements, slowed brain

and head growth, problems with walking,

seizures, and intellectual disability.

Before Dr. Zoghbi’s discovery, it had

not been proven that Rett was genetic.

Since then, other mutations in MECP2

have been linked to learning disabilities

and autism spectrum disorders.

“Recognizing the significant achieve-

ments of Dr. Zoghbi is exactly why this

distinguished visiting professorship ex-

ists,” said Dr. Carole Mendelson, Professor

of Biochemistry and of Obstetrics and

Gynecology, Director of the North Texas

March of Dimes Birth Defects Center and

current Co-Chair of the Women in Science

and Medicine Advisory Committee

(WISMAC) at UT Southwestern.

Adds Kathleen Gibson, President of

Southwestern Medical Foundation, “It is

an honor for the Foundation to support

WISMAC’s efforts for so many years and

to see its impact on faculty and students.

“Recognizing the significant achievements of Dr. Zoghbi is exactly why this distinguished visiting professorship exists.”

– Carole Mendelson, PhD

SPECIAL THANKS

As history amply attests, accomplishments are rarely achieved alone, and the produc-tion of this special issue of Perspectives is no exception. There have been many authors and stewards of history that have come before us. Some have passed away, and others are still with us; but their work was equally helpful to us in telling this story. We extend to them our sincerest gratitude and hope that we have been good custodians of this history as we share it with those who will pick up the torch for theadvancement of medicine going forward.

REFERENCES

Friedberg, MD, Errol C. From Rags to Riches: The Phenomenal Rise of the University of Texas Southwestern Medical Center. Durham: Carolina Academic Press, 2007.

Hazel, Michael V. “Medical Milestones: A Timeline.” Legacies. Spring 1993: 4-11.

Newsline: The Newsletter of Southwestern Medical Foundation. (Fall 1987 – Winter 1999).

Race, MD, PhD, George J. UT Southwestern: Commemorating the First Half Century. Dallas: UT Southwestern Medical Center, 1997.

Southwestern Medical Foundation News. (Spring 1955 – Spring 1987).

Southwestern Medical Perspectives: A Publication of Southwestern Medical Foundation. (Spring 1999 – Spring 2014).

UT Southwestern, CenterTimes, “History Special Edition, Celebrating the First Fifty Years: 1943-1993.”

SPECIAL THANKS

Edward H. Cary, III

Dallas County Medical Society and the Dallas Medical Journal archives

Harlan Crow and Cathy Golden, Old Parkland

The Dallas Morning News photo archives

Parkland Foundation, Beth Ellis Dexter

Dallas Public Library, Texas/Dallas History & Archives Division

Texas Medical Association library and archives

UT Southwestern Dean’s Office: Dr. J. Gregory Fitz and Diana DiLolle

UT Southwestern Facilities and Planning: Kirby Vahle and James Drake

UT Southwestern Medical School library and archives, Cameron Kainerstorfer

UT Southwestern Office of Business Affairs: Mike Serber and Abraham Mathew

UT Southwestern Student Affairs: Wes Norred and Chuck Kettlewell

Photo (Ziff) page 17: Terry Cockerham

Photo page 30: Tobbe Gustavsson/Reportage-bild/TT/Sipa USA

Photos pages 35 and 51: NASA photo library

Human Genome Project logo, page 44,courtesy U.S. Department of Energy Human Genome Project

Photo (Perot) page 50: Allan Warren

Photo page 65: Brian Coates

96

A moment in time that connected our remarkable past with its shining future. In 1943, at the first meeting of the Board of Trustees of Southwestern Medical College, the Board voted to establish an annual award to recognize the individual who best exemplified the qualities found in the ideal physician. It was named the Ho Din Award after a Greek acronym, which stands for “the spirit of medical wisdom.” Edward H. Cary, MD, one of the original founders of Southwestern Medical Foundation, envisioned the award and was also a recipient of the award. For more than 70 years, the Ho Din Award has been the foremost honor bestowed on the medical school’s most outstanding senior or, in rare instances, a faculty member. On May 30, 2014, the award ceremony found an extra measure of meaning when Edward Cary, III, the grandson of Dr. Cary, presented the Ho Din Award on behalf of the Foundation to a well-deserving Andrew Avery, MD, in recognition of his outstanding medical knowledge, understanding and compassion.

A Moment in Time

[ May 30, 2014 ]

Nonprofit Org.U.S. Postage

PAIDDallas, Texas

Permit No. 3997

PARKLAND HALL AT OLD PARKLAND3889 MAPLE AVENUE, SUITE 100DALLAS, TEXAS 75219

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Tell Us Your Story If you have a story, photo or anecdote that adds to the rich history of Southwestern Medical Foundation and you would like us to consider it for publication in an upcoming issue of Perspectives, we would love to hear it. Just send a brief synopsis and any photos to [email protected] or simply call 214-351-6143. We look forward to hearing from you.

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