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OME INVESTIGATIONS INTO THE CHEMICAL AND PHARMACEUTICAL ASPECTS OF YAGYOPATHY:

TUDIES IN PULMONARY TUBERCULOSIS

y : Meenakshi Raghuvanshi (1st PhD from DSVV)

y Ph. D. Thesis presents research study on chemical and pharmaceutical aspects of yagyopathic herbal

eatment of Pulmonary Tuberculosis. Yagyopathy (or Yagya-Therapy) is an ancient method of healing derived

om the Vedic Science.

agya and Gayatri are preeminent foundational elements of the Vedic Science and Culture. Pandit Shriram

harma Acharya, revered seer-sage of the present era had pioneered renaissance and expansion of both in new

ght.

n the process of yagya, herbal and plant medicinal sacrifices are made in the fire of specific type of wood in

specially designed fire-pit or brick and clay structure called (yagya) kunda. Slow combustion, sublimation, and

most prominently, the transformation into vapor phase of the sacrifised herbal and plant medicinal and nutritious

ubstances takes place in the yagya-fire. Yagya is a scientific method aimed at the finest utilization of the subtle

roperties of sacrifised matter with the help of the thermal energy of fire and the sonic vibrations of the mantras.

nhalation therapy and environmental purification are paramount applications of yagya apart from its enormous

ublime impact and auspicious spiritual effects sung with reverence in the Shastric Literature. Yagya is also calledomam, havan or agnihotra when conducted in a miniature form.

ecause of repeated rhythmic chanting of mantra and deep breathing, oral and nasal inhalation of medicinal

apors/gases/fumes (released from the processing of the herbal plant medicinal preparation in the yagya-fire)

ccurs naturally during yagya. Thus, yagyopathy (yagya-therapy) enables pulmonary administration of the herbal

medicines and is therefore expected to be a more efficient mode of healing in case of pulmonary diseases in

eneral and pulmonary tuberculosis in particular. Thorough scientific evaluation of this ancient therapy in the

eatment of pulmonary tuberculosis is the principal objective of my research work.

he yagyopathy experiments in my study were conducted using the fire-pit in the shape of Padma kunda which

constructed in the center of the Yagyopathy Lab of the Brahmvarchas research centre, Shantikunj, Hardwar.

he lab is surrounded by glass walls with appropriate facil ities of controlled ventilation and exhaust through theoof which can be connected (at the terrace of the lab) to desired instruments for collection and analysis of the

eleased medicinal fumes/gases/vapors etc.

harmaceutical investigations into a new mode of therapy require both clinical studies and pharmacokinetic

nalysis. These aspects of yagyopathic treatment of Pulmonary Tuberculosis are presented in my thesis.

wo experiments were conducted on some commonly found air-born microbes (including E.coli, Pseudomonas,

treptococci, and few Fungi strains). The samples exposed to yagya for few minutes showed about 70% reduction

growth as compared to the control cultures of the same bacteria which were exposed for same time to a slum

rea away from the place of yagya.

ome experiments were also conducted on samples from the sputum of patients who were diagnosed positive inhe AFB (acid fast bacilli) test. These Mycobacteria (M. tubercular) were cultured on two sets of solid Lowerstein

ensen medium slant and liquid Kirchner medium. One set from each patients sample was used as control and

he other as experimental. Yagya-output (medicinal vapors/gases/fumes) was passed in the experimental

amples for about 35-40 minutes using SKC Air check 2000 air sampling pump and high flow vacuum pump. The

tter was obtained from PCRI at BHEL Hardwar. The control samples were not treated with yagya. After

cubation at 35-37C for eight weeks, the growth in the sets treated with yagya-output was found to be about

5% less as compared to the control groups.

n order to evaluate the pharmaceutical potentials of yagyopathy on humans, I have conducted a clinical trial

tudy on 15 patients of Pulmonary Tuberculosis in the age group of 15-60 years. The yagya experiment was

erformed in the yagyopathy lab Brahmvarchas Research Centre, Shantikunj, Hardwar using the anti-tubercular

erbal preparation of Ayurvedic plant medicines. The yagya used to be performed for 30-45 minutes every dayith repeated loud rhythmic chanting of the Gayatri Mantra during the process of ahutis and deep breathing for

ew minutes after the ahutis (sacrifices of measured quantity of herbal/plant medicinal preparations in the yagya-

re) were completed. Duration of regular participation of a patient was about 35 to 75 days depending upon the

inical trials based on the sequential readings and statistical pattern of changes.

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he effects were tested by sequential readings (per 10 to 20 days as per the bio-statistical design) on different

inical physiological, microbiological, haematological, biochemical and pathological (including chest radiography)

arameters of importance during the course of study. The qualitative symptoms and clinical features of relevance

cluded loss of appetite, heaviness in chest, expectoration, body-temperature, BP, etc. The analysis showed

xcellent healing possibili ties of yagyopathy in Pulmonary Tuberculosis. Changes in important qualitative

ymptoms and clinical, pathological and haemetological parameters (including ESR, chest radiograph/X-ray and

ulmonary functions) showed clinically significant recovery with high statistical confidence.

imilar kind of study was made on a control group of ten patients; all of whom were under allopathic medication.he control group was comparable with the experimental group (without the outlier) in terms of age-group,

ender ratio, state of disease, locality etc, but no patient in this group participated in any yagya. Sequential

eadings on the above parameters were taken in manner similar to those in the experimental group. However,

he results on changes in the important symptoms and signs (including the pathological, radiological and

ulmonary parameters) were neither clinically nor statistically significant.

hysiological type compartment models for pharmacokinetic (PK) analysis of yagyopathy as a mode of pulmonary

rug administration is presented in my thesis. Its performance is compared with the oral and intravenous (i.v.)

rug administration by theoretical (mathematical) analysis and computational simulations using relevant data (for

K parameters such as mass transfer rate constants, blood flow rates, etc) from empirical PK studies on adult

ndians.

he results show yagyopathy as remarkably better both in terms of residential time and drug availability at the

te of action which in the case of Pulmonary Tuberculosis happens to be lungs. It is also notable that the

hysiological compartment modelling, theoretical analysis and associated simulations [15] here provide results on

bsolute (bio)availability rather than average estimators (as in empirical PK analysis).

he results of in-vitro experiments, clinical trials and pharmacokinetic models and analysis carried out in my Ph.

. work show remarkable potential of yagyopathy as an effective therapy against Pulmonary Tuberculosis.

tudies of this kind on other diseases (including psychosomatic disorders) would be immediate extensions of this

esearch. Future projects demanding original research would include (i) collaboration with pharmacologists;

i) empirical pharmacokinetic and pharmaco-dynamic studies; (iii) the lung-deposition studies of yagyopathy

xperiment with cascade impactor based fine particle fraction techniques, or the advanced imaging techniques

ke gamma-sccintiography, etc (iv) study of the role of mantras in yagyopathy.

eferences:

aghuvanshi Meenakshi (2006): Some Investigations into the Chemical And Pharmaceutical Aspects of

agyopathy: Studies In Pulmonary Tuberculosis (Ph.D.Thesis)

oshi R. R., Raghuvanshi M. and Pandya P. (2006): Yagyopathy vs. Oral and I.V. Drug Administration Evaluation

or Pulmonary TB using Physiological Compartment Modelling- Journal of Biological Systems Vol. 14, No. 3 pp.

63

aghuvanshi M., Pandya P. and Joshi R.R. (2004): Yagyopathic Herbal Treatment of Pulmonary Tuberculosis

ymptoms A Clinical Trial. Alternat. & Complemen. Therapy. Vol. 10 (2), pp. 101-105.

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