solutions for molecular - perkinelmer 珀金埃尔默€¦ · solutions for molecular ... less pbs...

VALIDATED SOLUTIONS FOR MOLECULAR CYTOGENETICISTS

PRODUCTS AND METHODOLOGIES Not for distribution in the USA

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Signature Genomics has established cutting-edge methodologies that are now standard in molecular cytogenetics. Founded in 2003 Signature Genomics has analyzed over 50,000 cytogenetic samples and established a powerful database of abnormalities. Based on this information a unique aCGH array design has been defined that targets relevant regions for molecular cytogenetic analysis.

PerkinElmer is a global scientific leader that is taking action to improve the health and safety of people and their environment. We are committed to protecting the health of expectant mothers, babies and families. PerkinElmer is the world’s leading supplier of newborn screening systems, a pioneer in methods for risk assessment during pregnancy and a leader in cord blood banking. Following its acquisition by PerkinElmer in 2010, Signature Genomics has enhanced PerkinElmer’s molecular cytogenetics expertise.

As one of the pioneers in the field of molecular cytogenetic analysis, we continuously work towards innovation and development of cutting-edge technologies to improve human health. We aim to share our experience and expertise with the global cytogenetics community and significantly advance the field of cytogenetics.

SIGNATURE GENOMICS - CYTOGENETICS PIONEER

A GLOBAL LEADER IN HUMAN AND ENVIRONMENTAL HEALTH

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PerkinElmer is bringing the newest molecular techniques to cytogenetic laboratories.

Our innovative methodologies support:

• Higher detection rates

• More results - faster & cheaper

• Fewer unclear results

• Streamlined processes

• PerkinElmer support from sample to result

Oligonucleotide-based microarrays and bead-based multiplex BACs-on-Beads™ (BoBs) products have been specifically designed, developed and validated by cytogeneticists for cytogeneticists performing molecular karyotyping.

With the recent acquisition of chemagen, PerkinElmer is now able to support the entire workflow incorporating automated DNA/RNA isolation solutions.

PERKINELMER - INNOVATORS IN MOLECULAR CYTOGENETICS

PerkinElmer is working with its sizeable customer base (in the regions marked blue on the map) to advance health care.

Faster results – higher sensitivity

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chemagen Technology - DNA/RNA extraction and purification.....................................6

EasyAmp - Single cell whole genome amplification....................................................8

BACs-on-Beads - Power to expand on existing FISH capabilities...............................9

PRODUCTS AND METHODOLOGIESCONTENTS

Products for Research

Products for IVD

KaryoLite BoBs....................................................................................................11

CGX Oligo Arrays.................................................................................................13

CGX™ Hybridization Oven...................................................................................14

ScanRI Scanner...................................................................................................15

Genoglyphix® visualization software and database...........................................16

Prenatal BoBs....................................................................................................18

Array CGH - A comprehensive product portfolio............................................................12

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UNIQUETECHNOLOGYFOR DNA/RNAISOLATION

As the number of samples increases, the need for automation becomes more acute. Automation also offers better reproducibility and reliability in the isolation process. The key competence behind chemagen Technology is the isolation of genomic DNA and total RNA. This competence is expressed in chemagic Kit products, which contain proprietary magnetic particles with a high affinity to nucleic acids and low protein binding.

A crucial step in human genetic testing is the isolation of high quality DNA or RNA.

PerkinElmer’s chemagen Technology offers flexible solutions for applications in:

chemagen Technology – Complete Solutions for DNA/RNA Isolation in Human Genetics

• Biobanking

• Human Genetics

• Epigenetics

• 10 μl - 10 ml samples with one instrument• Wide variety of sample material (Blood,

Blood Spots, Plasma, Cells, Tissue)• Easy to connect to standard liquid handling systems

• Up to 1 ml samples, 1 - 12 samples in parallel• Pre-installed protocols• Cost-effective sample preparation

• Several kits for the isolation of genomic DNA and total RNA

• Suitable for use with liquid handling instruments and automated magnetic bead-based platforms

• Available as manual kits

CHEMAGIC MSM I – OUTSTANDING FLEXIBILITY

CHEMAGIC PREPITO – INNOVATIVE BENCHTOP SOLUTION

CHEMAGIC KITS - MAGNETIC BEADS FOR ENDLESS POSSIBILITIES

All products listed are for Research Use Only. Not for use in diagnostic procedures.

DNA/RNA ISOLATION

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CHEMAGIC

KITS OVERVIEW

The chemagic Kit portfolio comprises a large number of kits for the isolation of DNA and RNA.

Instrument

chemagic MSM I

chemagic MSM I

chemagic MSM I

chemagic MSM I

chemagic MSM I

chemagic Prepito

chemagic Prepito

chemagic Prepito

chemagic Prepito

Manual or on LH instruments

Instrument

chemagic MSM I

chemagic MSM I

chemagic MSM I

chemagic MSM I

chemagic Prepito

chemagic Prepito

Instrument

chemagic MSM I

chemagic MSM I

chemagic MSM I

Sample Volumes

50 µl - 400 µl blood 1 ml - 4 ml blood 3 ml - 10 ml blood

Paper filter punch outs

4 ml saliva

1 swab

1.2 x 107 cells

100 µl - 250 µl

600 µl

10 µm section

animal tissues or cells

5 µl - 20 µl (without ethanol)

Sample Volumes

1 ml serum/plasma 4 ml serum/plasma

1 ml amniotic fluid

5 ml plasma 4 ml plasma

up to 500 µl bisulfite reaction mix

250 µl blood, 10 mg tissue or 1 - 5 ml pelleted amniotic fluid

1 ml serum/plasma

Sample Volumes

2.5 ml stabilized blood 2.5 ml stabilized blood

1 ml serum/plasma

2 ml blood or bone marrow; max. cell number 20 x 106

Samples/Run

96 24 12

96

24

96

12

12

6

12

12

Samples/Run

12 24

12

12 12

96

12

12

Samples/Run

12 24

12

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Human Genetics projects and Biobanking

chemagic DNA Blood Kit special

chemagic DNA Blood Spot Kit special

chemagic DNA Saliva Kit special

chemagic DNA Buccal Swab Kit special

chemagic DNA Cell12M Kit special

Prepito DNA Blood250 Kit

Prepito DNA Blood600 Kit

Prepito FFPE Kit

Prepito DNA Tissue Kit

chemagic SEQ Pure Kit

Prenatal Genetics and Epigenetics

chemagic Circulating NA Kit Special

chemagic Amniotic Fluid Kit special

chemagic Epigenetic NA Extraction Kit special

chemagic Epigenetic Bisulfite Purification Kit special

Prepito DNA Cyto Pure Kit

Prepito Circulating NA1k Kit

Isolation of total RNA

chemagic RNA Blood Kit special

chemagic RNA Saliva Kit special

chemagic mRNA/gDNA Kit special

Further chemagic Kits are available on request. Products listed are for Research Use Only. Not for use in diagnostic procedures.

DNA/RNA ISOLATION

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Lysis/extractionbuffer

Amplificationcocktail

Pre-ampcocktail

Add cell in ~2 microliters or less PBS

15 min 90 min 60 min

3 µg aDNA

Analysis

Single Cell Whole Genome Amplification with EasyAmp™ • Simple 1-tube, 3-step and 3 hour

protocol

• Eight components sufficient to perform 50 (or 12) reactions

• About 1 million fold amplification of a single cell to produce 3-5 micrograms of DNA

• Low background

• Reproducible locus amplification

• No allele bias

RAPID AND ROBUST ONE-TUBE PROTOCOL

EASYAMP EasyAmp™ is a single cell whole genome amplification (WGA) kit that can be used when the amount of DNA is not sufficient to perform the direct

analysis, e.g. research in vitro fertilization (IVF) applications on single cells. EasyAmp WGA is based on technology from Rubicon Genomics.

Reliable and Reproducible Amplification Technology

EasyAmp enables the researcher to obtain the amountof DNA from only one cell that previously required over 10,000 cells for subsequent analyses. EasyAmp, in contrast to other single cell amplification methods, delivers amplified genomic DNA that reproducibly represents all sequences with low allele drop out. EasyAmp can be used on polar bodies, blastomere or blastocyst cells for preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS) research applications.

The EasyAmp™ whole genome amplification process amplifies a single cell’s DNA approximately one million-fold to give 3-5 micrograms of amplified DNA.

EasyAmp reagents are for Research Use Only. Not for use in diagnostic procedures.

WHOLE GENOME AMPLIFICATION

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is an exciting new technology from PerkinElmer. By immobilizing BAC (bacterial

artificial chromosome) derived DNA probes onto Luminex® xMAP® fluorescently coded beads, BoBs enables rapid detection of copy number changes in targeted genomic regions from a minute amount of DNA. BACs-on-Beads technology supports high throughput molecular karyotyping in a microplate well which, in turn, can lead to greater laboratory efficiency and better use of resources.

Expand on your FISH capability using BoBs technology

BACs are large cloned sequences of human DNA, typically 150,000 - 170,000 basepairs long. When coupled to Luminex® xMAP® beads, the length of the BACs is a useful property. BAC derived DNA probes have a higher signal-to-noise ratio compared to smaller DNA probes regardless of the DNA quality. This represents an important advantage when working with samples such as amniotic fluid, CVS, POC (product of conception) and DNA amplified from single or few cells. The advantage of BACs over oligonucleotides, which are often less than 100 basepairs long, is that fewer probes are needed for the same coverage of a target region. Results of unclear clinical significance that are common with other fast molecular karyotyping techniques are rarely encountered with the new BACs-on-Beads assays. BAC DNA has long been used as probes for FISH (fluorescence in situ hybridization) in cytogenetic laboratories. Now, with the availability of the BACs-on-Beads technology multiple FISH probes can be handled in a single well and you can perform the equivalent of tens to hundreds of FISH experiments simultaneously.

THE POWER OF BACS-ON-BEADS

BACs-on-Beads™ (BoBs™)

BACS-ON-BEADS TECHNOLOGY

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BOBS PRODUCTS BRING THESE BENEFITS TO YOUR WORK

• Robust assay with low quality DNA from various sample types

• Enables high throughput analysis as tens of samples can be run simultaneously reducing the hands-on time

• Resources are optimized as sample volume can be increased without increasing staffing

• Complete procedure from extracted DNA to result availability takes less than 24 hours

• Results are clear and easy to interpret

• More information due to the multiplexing power of xMAP®

is an established multiplexing technology utilizing approximately 5 μm diameter polystyrene beads that have been impregnated with a specific ratio

of two different fluorescent dyes.

By using ten different concentrations of each of the two dyes it is possible to generate up to 100 bead types with distinct fluorescent signatures, or spectral addresses that can be identified through excitation of the impregnated dyes when read by the Luminex 100/200™ instrument.

The advantage of the Luminex® instrument platform lies in the fact that up to 100 different bead types can be mixed together and the experiment can be performed in a multiplexed fashion using microplates. The instrument can automatically aspirate the beads from each well of a 96-well plate, and by use of a flow system that allows one bead to be interrogated by two lasers simultaneously, all beads can be classified and quantified within the assay in a short amount of time.

Easy interpretation of the Copy Number Changes with BoBsoft™ Analysis Software

BoBsoft™ analysis software takes the output file generated by the Luminex® 100/200™ instrument, and analyzes the data. The signal intensities from the sample and reference DNA are compared to provide a clear display of any copy number changes in the targeted regions.

Assay Based on Luminex® xMAP® Technology

LUMINEX XMAP TECHNOLOGY


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KaryoLite BoBs™ has been developed to detect arm specific aneuploidies in all 24

chromosomes in a single assay for research use only. The product covers p and q arms of all chromosomes 1-22, X and Y. Based on the BACs-on-Beads technology, it consists of BAC DNA immobilized onto polystyrene microspheres distinguishable by the Luminex® instrument system.

KaryoLite BoBs utilizes a new concept of composite beads having DNA from three different BAC clones on each bead type. The composite clone format expands the region of chromosomal DNA interrogated by each bead.

KARYOLITE BOBS™

Research may be performed with KaryoLite BoBs using only 50 ng of genomic DNA extracted directly from amniotic fluid, chorionic villae or fetal tissue. As no cell culturing is required with any BoBs assay, KaryoLite BoBs offers a clear advantage over conventional cytogenetic techniques in cases in which cell culture is problematic, for example in POC (product of conception) analysis.

Results in Under 24 hours with Hands-On Time ~ 3.5 hoursThe probes used have been carefully selected to give information about the whole chromosome including the distal and proximal region of the chromosome arms. For acrocentric chromosomes (13, 14, 15, 21 and 22) three beads have been selected to cover exclusively the q-arms.

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24 Chromosomes in 24 Hours

KaryoLite BoBs reagents are for Research Use Only. Not for use in diagnostic procedures.

KARYOLITE

BOBS

KaryoLite BoBs utilizes a new concept of composite beads having three different BAC clones on each bead type.


See these references Grati FR et al. Application of a new molecular technique for the genetic evaluation of products of conception. Prenat Diagn. 2012, 32, 1–10. DOI: 10.1002/pd.4004. Paxton CN et al. Rapid aneusomy detection in products of conception using the KaryoLite™ BACS-on-Beads™ assay. Prenat Diagn. 2012, 32, 1-7. DOI: 10.1002/pd.4003.

ARRAY

CGH

ARRAY COMPARATIVE GENOMIC HYBRIDIZATION TECHNOLOGY

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Oligonucleotide Array CGH Solution developed by Signature Genomics Traditional karyotyping methods,

such as FISH or G-banding, are well established for detecting

chromosomal aberrations however, these methods are limited by speed, throughput and resolution.

While these traditional methods are able to detect microscopic visible chromosomal alterations such as an extra chromosome band, smaller gains or losses in the genome cannot be found reliably. Array CGH in contrast enables higher resolution genome analysis and allows the detection of submicroscopic chromosomal imbalances across the genome in one single experiment.

As one of the pioneers in the field of Molecular Cytogenetics, Signature Genomics, a PerkinElmer company, has early on established cutting-edge technologies that are now the standard for detection of chromosomal abnormalities.

Signature Genomics from the beginning has used a ‘genotype-first’ approach and has developed an oligoarray design for the detection of submicroscopic aberrations associated with learning disability and dysmorphic features. This array design has led to a partnership between Signature Genomics, PerkinElmer and Agilent Technologies, Inc.

This partnership allows clinical researchers access to relevant cytogenetic content through the use of our streamlined and robust CGX workflow.

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CGXOLIGO ARRAYS

• Proven design, representing over 245 known syndromic regions and over 980 functionally significant genes

• Three different array types based on the same design to adjust for throughput and detection requirements including Absence of Heterozygosity (AOH) and Uniparental Disomy (UPD) detection

– CGX™: 8x60K with a resolution of 190 kb in the backbone, and 28 kb in the targeted regions

– CGX™-HD: 4x180K with a resolution of 40 kb in the backbone, and 20 kb in the targeted regions

– CGX™-SNP: 4x180K with a resolution of 80 kb in the backbone, and 20 kb in the targeted regions. In addition, detection of contiguous stretches of Absence of Heterozygosity (AOH) of approximately 5-10 Mb

• All designs updated to HG19

CGX OLIGO ARRAYS CHARACTERISTICS THAT WILL BENEFIT YOUR WORK

specifically designed, developed and verified by Signature Genomics for the

detection of small genetic aberrations associated with learning disability and dysmorphic features in research applications. The oligonucleotide probes on the CGX™, CGX™-HD and CGX™-SNP arrays cover the entire human genome with specific focus on over 245 cytogenetically relevant regions, 980 functionally significant genes, pericentromeric regions, and subtelomeres.

Almost every abnormality detected by CGX Oligo Arrays can be visualized by FISH

FISH confirmation might be required to identify structural changes and the possible source of any change. With the possibility for ordering unlabeled BAC clone DNA for confirmation purposes, PerkinElmer offers a total solution package consisting of discovery and confirmation options.

CGX Oligo Arrays are oligonucleotide-based microarrays

CGX Oligo Arrays are Research Use Only products. Not for use in diagnostic procedures. CGX Oligo Arrays are designed by Signature Genomics and manufactured by Agilent Technologies, Inc.


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OVEN

• Rotator Motor Speed 2 to 20 RPM

• Approximate Oven Height: 22.0" (55.8 cm) Dimensions Width: 17.4" (44.5 cm) Depth: 17.75" (39.5 cm)

• Approximate Chamber Height: 14.5" (36.8 cm) Dimensions Width: 12.5" (31.8 cm) Depth: 12.0" (30.5 cm)

• Operating Temperature Range + 5° to 70°C (+/- 0.1°C)

• Weight 75 lbs (34.0 kg)

• Power Input 110-120 volts, 220-240 volts

• Hybridization Chamber Holds up to 24 hybridization Rotator Rack chambers during hybridization

• High Throughput The oven is designed to hold up to 24 CGX™ Hybridization Chambers.

• Consistent Data Reproducible results; increased sensitivity and specificity.

• Flexibility

• Variable temperature control range; from + 5° to 70°C (+/- 0.1°C)

• Variable rotation speed control from 5 to 20 RPM.

SPECIFICATIONS

The CGX™ Hybridization Oven is designed for optimal hybridization performance to achieve consistent and reliable results. The oven is a compact

and flexible instrument designed for an optimal microarray processing workflow.

CGX™ Hybridization Oven


CGX™ HYBRIDIZATION

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ScanRI™ is one of the fastest microarray scanners on the market enabling the capture of images in approximately 20 min when scanned at 3 μm resolution.

It provides simultaneous 2-color image acquisition with scanning resolution from 3 μm to 40 μm. Combined with its small size, low background noise and high sensitivity, ScanRI provides an attractive solution for array users.

Fast and Sensitive Scanning with ScanRI

• Weight 15.5 kg

• Dimensions 278 x 457 x 369 mm3

• Laser excitation wavelengths of 532 nm and 635 nm

• Simultaneous 2-color scanning

• Scanning resolution from 3 μm to 40 μm

• Low background noise and high sensitivity

• Uniform scanning across the microarray slide

SCANRI SCANNER - MAIN SPECIFICATIONS

SCANNING AND VISUALIZATION


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DESIGNED BY CYTOGENETICISTS FOR CYTOGENETICISTS

Genoglyphix® sets a new standard for array based cytogenetic analysis. Developed by Signature Genomics and available exclusively with CGX oligo arrays, Genoglyphix® genome browser software provides intuitive data visualization and annotation features for streamlined and rapid analysis of CGX data.

Genoglyphix® is a powerful data visualization software and database based

on the analysis of over 50,000 verified cytogenetic samples.

Genoglyphix® offers a proven analysis tool with a complete workflow including sample tracking, aberration categorization, data interpretation, report creation functionality and data sharing options with other Genoglyphix® users worldwide.

Genoglyphix®: turning 50,000 samples into meaning • Access to Signature’s database containing

over 12,000 verified genetic alterations identified in over 50,000 samples

• Direct links to other relevant databases such as the DGV, OMIM, PubMed, UCSC and Ensembl for easy data interpretation

• Secure web based (128-bit encryption) access to Genoglyphix® database and software

• Generation user defined databases and custom tracks displaying abnormal results, copy number variants and analysis notes

• Data display in HG18 or HG19

• Report creation functionality

• Optional sharing of data with other Genoglyphix® users

• Availability of FISH probes for result confirmation

GENOGLYPHIX® – BRINGING MULTIPLE GENETIC DATABASES INTO ONE TOOL

GENOGLYPHIX® EASILY GUIDES CYTOGENETICISTS THROUGH ANALYSIS WITH CONVENIENT TOOLS

PERKINELMER ARRAY SOFTWARE SOLUTIONS

Genoglyphix® software is for Research Use Only. Not for use in diagnostic procedures.


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GENOGLYPHIX® GENOMEBROWSER

GRAPHICAL REPRESENTATION OF ABERRATIONS IN THE GENOGLYPHIX® GENOME BROWSER

• Display of normal copy number variation in DGV within the selected genomic region


• Display of GC content in the selected genomic region

• Display of known syndromes within the selected genomic region

• Display of similar aberrations within the Signature Genomics data base

• Display of genes within the selected genomic region

Prenatal BoBs™ is a CE-marked IVD product based on BACs-on-Beads technology. In addition to detecting copy number changes of chromosomes 13, 18, 21, X and Y, the product enables detection of 9 additional chromosomal regions in which

a clear correlation between a loss and an adverse outcome has been demonstrated.1 Copy number changes in these targeted microdeletion regions are not easily found with other commonly used methods. Also the microdeletion syndromes detected by Prenatal BoBs often are not inherited and do not display ultrasound abnormalities, so they may otherwise be missed in a prenatal setting.

LITERATURE: 1. OMIM: http://www.ncbi.nlm.nih.gov/omim/ #105830, #123450, #150230, #176270, #182290, #188400, #194050, #194190, and #2472002. Vialard et al. Prenatal BACs-on-Beads: the prospective experience of five prenatal diagnosis laboratories, Prenat Diagn. 2012, 32, 329-335.

See also Cheng YKY et al. The detection of mosaicism by Prenatal BoBs™ Prenat Diagn. 2012, 32, 1–8 DOI: 10.1002/pd.4006. Gross SJ et al. Rapid and novel prenatal molecular assay for detecting aneuploidies and microdeletion syndromes, Prenat Diagn. 2011 Mar;31(3):259-66. Vialard F et al. Prenatal BACs-on-Beads: a new technology for rapid detection of aneuploidies and microdeletions in prenatal diagnosis, Prenat Diagn. 2011 May;31(5):500-8.Shaffer LG et al. The development of a rapid assay for prenatal testing of common aneuploidies and microdeletion syndromes, Prenat Diagn. 2011 Aug;31(8):778-87.Popowski T et al. Williams-Beuren Syndrome: the prenatal phenotype, Am. J. Obs & Gyn. 2011.Izzo A et al. 40 Mb duplication in chromosome band 5p13.1p15.33 with 800 kb terminal deletion in a foetus with mild phenotypic features, Eur. J. Med. Genet. 2012 Feb 55 (2) 140-144.

IVD PRODUCT

Low Input Material – Fast Results Analysis using Prenatal BoBs can be performed with 50-250 ng genomic DNA, an amount which can be obtained from 3-5 mL of amniotic fluid or from 1 villus. Results are ready in 24-48 hours from the time of sampling. Clear Result Interpretation

In Prenatal BoBs a gain or loss of a region is called if three or more probes within a given target region exceed the cut-off for gain or loss. Frequencies of aneuploidies and single microdeletion syndromes vary from common to rare. It is expected that there is a finding of an aneuploidy or microdeletion syndrome region with the Prenatal BoBs kit in every 1/250 births.2

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Microdeletion Syndrome Cytoband

DiGeorge Syndrome 22q11.2

DiGeorge 2 Syndrome 10p14

Williams-Beuren Syndrome 7q11.2

Prader-Willi Syndrome 15q11-q12

Angelman Syndrome 15q11-q12

Smith-Magenis Syndrome 17p11.2

Wolf-Hirschhorn Syndrome 4p16.3

Cri du Chat Syndrome 5p15.3-p15.2

Langer-Giedion Syndrome 8q23-q24

Miller-Dieker Syndrome 17p13.3

Aneuploidies Cytoband

Trisomy 13: Patau Syndrome Chr 13

Trisomy 18: Edwards Syndrome Chr 18

Trisomy 21: Down Syndrome Chr 21

Sex Chromosome Abnormalities Chr X, Chr Y

A more informative option than FISH and QF-PCR for IVD Labs

PRENATAL

BOBS

Prenatal BoBs reagents are not available in the USA and Canada.

In other countries please check availability with your PerkinElmer sales representative.

Prenatal BoBs is a

CE-marked IVD

product based on

PerkinElmer BACs-on-

Beads technology

(described on pages

9-10).

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Product Name

Prenatal BoBs™

Luminex® 200 w/ xPONENT®

BoBsoft 1.1 Analysis Software

BoBsoft 2.0 Analysis Software

Product Number

IVD

3100-0020

1014-0020

5012-0020

5012-0202

ORDERING INFORMATIONProduct Name

chemagic DNA Blood Kit special, 50 µl, 96 samples




chemagic DNA Blood Kit special, 1 ml, 24 samples



chemagic DNA Blood Kit special (4 ml elution tubes), 3 ml, 12 samples






chemagic DNA Blood Spot Kit special, 3 - 6 mm paperfilter punch outs, 96 samples

chemagic DNA Saliva Kit special, 4 ml, 24 samples

chemagic DNA Saliva Kit special, 12 samples

chemagic DNA Buccal Swab Kit special, 96 samples

chemagic DNA Cell12M Kit special, 12 samples

Prepito DNA Blood250 Kit, 12 samples

Prepito DNA Blood600 Kit, 6 samples

Prepito FFPE Kit, 10 µm section, 12 samples

Prepito DNA Tissue10 Kit, 10 mg tissue, 12 samples

chemagic SEQ Pure Kit, 10 - 20 µl

chemagic SEQ Pure Kit LH, 10 µl

chemagic SEQ Pure Kit LH, 20 µl

chemagic Circulating NA Kit special, 1 ml, 12 samples

chemagic Circulating NA Kit special, 4 ml, 24 samples

chemagic DNA Amniotic Fluid Kit special, 1 ml, 12 samples

chemagic Epigenetic NA Extraction Kit special, 5 ml, 12 samples

chemagic Epigenetic NA Extraction Kit special, 4 ml, 24 samples

chemagic Epigenetic Bisulfite Purification Kit special, 500 µl, 96 samples

Prepito DNA Cyto Pure Kit, 12 samples

Prepito Circulating NA1k Kit, 6 samples

chemagic RNA Blood Kit special, 12 samples

chemagic RNA Blood Kit special, 24 samples

chemagic RNA Saliva Kit special, 1 ml, 12 samples

chemagic mRNA/gDNA Kit special, 2 ml blood or bone marrow, 12 samples

Product Name

EasyAmp 50 reaction WGA kit

EasyAmp 12 reaction WGA kit

Luminex® 200 w/ xPONENT®

Constitutional BoBs

KaryoLite™ BoBs™

BoBsoft 1.1 Research Analysis Software

BoBsoft 2.0 Research Analysis Software

ScanRI

ScanRI PC

Genoglyphix SW

CGX™ HD/SNP Gasket Slides-100

CGX™ Gasket Slides-100

CGX™ HD/SNP Gasket Slides-20

CGX™ Gasket Slides-20

CGX™ Ozone-barrier slide covers

CGX™ (2 slides per pack)

CGX™ (4 slides per pack)

CGX™ HD (2 slides per pack)

CGX™ HD (4 slides per pack)

CGX™ SNP (2 slides per pack)

CGX™ SNP (4 slides per pack)

CGX™ Hybridization chamber, stainless

CGX™ Hybridization oven

CGX™ Hybridization oven rotator

CGX™ Cot-1 Human DNA

CGX™ Oligo aCGH Hybridization Kit

CGX™ Oligo aCGH Wash Kit

CGX™ DNA Labeling Kit – Purification Columns

CGX™ Stabilization and Drying Solution

CGX™ DNA Labeling Kit

Product Number

chemagen products

CMG-1072

CMG-721

CMG-746

CMG-1091

CMG-1086

CMG-1097

CMG-1074

CMG-763-1

CMG-763-2

CMG-703-1

CMG-703-2

CMG-715

CMG-704

CMG-1030

CMG-1081

CMG-1035

CMG-748

CMG-756

CMG-2002

CMG-2004

CMG-2027

CMG-2010

CMG-108

CMG-459

CMG-458

CMG-1096

CMG-1090

CMG-797

CMG-1068

CMG-1088

CMG-1069

CMG-2034

CMG-2025

CMG-1083

CMG-1084

CMG-1093

CMG-1031

Product Number

Easy Amp

4502-0010

4503-0010

BACs-on-Beads

1014-0020

4500-0020

4501-0010

5012-0010

5012-0102

CGX™

1013-0010

1013-0020

5016-0010

4113-0010

4114-0010

4115-0010

4116-0010

4117-0010

4118-0010

4119-0010

4122-0010

4123-0010

4124-0010

4125-0010

1015-0020

1015-0040

1015-0030

4130-0010

4131-0010

4132-0010

4135-0010-P4

4134-0010

4135-0010

PerkinElmer, Inc. PerkinElmer, Inc.940 Winter Street Wallac OyWaltham, MA 02451 USA PO Box 10Phone: (800) 762-4000 or 20101 Turku, Finland(+1) 203-925-4602 Phone: (+ 358) 22678-111www.perkinelmer.com Fax: (+ 358) 22678-357

Signature Genomics/ PerkinElmer2820 N. Astor StreetSpokane, WA 99207 USAPhone: (+1) 877-744-2447

PerkinElmer chemagen Technologie GmbHArnold-Sommerfel-Ring 252499 Baesweiler, GermanyPhone: (+49) 2401-805500

ISO 13485ISO 9001CMDCASISO 14001OHSAS 18001

For a complete listing of our global offices, visit www.perkinelmer.com/ContactUs

©2012 PerkinElmer, Inc. All rights reserved. PerkinElmer is a registered trademark of PerkinElmer, Inc. All other trademarks depicted are the property of their respective holders or owners. PerkinElmer reserves the right to change this document at any time and disclaims liability for editorial, pictorial or typographical errors.

1244-9963-05, December 2012

solutions for molecular - perkinelmer 珀金埃尔默€¦ · solutions for molecular ... less pbs...

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