Slot 1: Diagram of Respiratory System• Extrapulmonary • n=nasal • m=mouth • t=trachea • b=bronchi

• 1º

• Intrapulmonary • bronchi

• 2º • 3º

• rb=respiratory bronchiole

• tb=terminal bronchiole

• a=aveoli • as=aveolar sac • at=atria • ad=aveolar duct

Pharynx

Slot 5.1

Slot 5.2: Nasal conchae

Olfactory epithelia; no goblet cells

Thicker than respiratory lining

Respiratory Epithelium -

1/3 height nuclear free borderBasal Cells

Sustentacular

cells

Goblet cells

Slot 5.3: Larynx

Vocalis Muscle

Respiratory Epithelium Cartilage

Epiglottis

Stratified Squamous

Esophagous

T = trachea

Vocal ligament position

Slot 5.4: Trachea

• A=adventitia • C=cartilage • P=pericondrial

membrane • Green=submucosa • YellowYellow line = elastic

membrane • Pink=respiratory

epithelium • E=pseudostratified

epithelial cells (has goblet)

• L=lamina propria • M=trachealis muscle

(smooth)

Hyaline cartilage

Fibrocartilagenous coat

Slot 5.5: Trachea-bronchi junction

• LB=left bronchi – (1º branch)

• RB=right bronchi – (1º branch)

• C=cartilage • T=trachea

Slot 5.6: Sections of Intrapulmonary bronchus

• m=muscularis mucosa • c=cartilage • Arrowhead: mast cells • v=capillaries

Respiratory epithelium

Lamina propria

Submucosa

Mucoserous glands

Slot 5.7 Bronchioles

• arrows=patches of cilia • arrowheads= clara cells (secret surfactant) • m=muscularis mucosa • a=alveoli • Deep folds do not exist in live animals• c= clara cell

Slot 5.8: Lung Diagram

• Green line = simple cuboidal epithelium; No goblet cells

• tb=terminal bronchioles

• rb=respiratory bronchioles

• A=alveoli, At=atrium, Ad=alveolar duct

• Arrows=aveolar pores • s=alveolar sac • (2)=simple squamous

Simple cuboidal

Slot 5.9: Alveoli

• A=alveoli p=pulmonary macrophage • e=endothelial cell f=fibroblast cell • s=septa between alveoli g=type II pneumocyte (surfactant)• arrowhead= diffusion barrier

Bas

al c

ells

Olfactory cells

Sust

enta

cula

r cel

ls

Microvilli

Lamina propria

Bowman’s gland (serous)

Nuclear free border (1/5)

NerveSlot 5.10: Nasal conchae

Slot 5.11: Nasal conchae• N=nerve • D=duct• B= turbinate bone • V=dilated blood vessels

Respiratory epithelium

Slot 5.12: Larynx: sagittal section

Epiglottis

Vocalis Muscle

Slot 5.13

Trachea (c.s.)

Hyaline cartilage

submucosa

Lamina propria

Respiratory epithelium

adventitia

artifact

Slot 5. 14: Extrapulmonary BronchusRespiratory epitheliumLamina propria

Submucosa

Hyaline cartilage

Vein

M. mucosa

Slot 5.15: Intrapulmonary Bronchus

Muscularis mucosa

Lamina propria

Ciliated Respiratory epithelium

Alveolar sacs

Cartilage

Slot 5.16: Diagram of

smaller respiratory tubes

Slot 5.17: Bronchiole

Bronchiole

Artery

M. mucosa

Alveolar ducts and sacs

Slot 5.18: Alveolar duct, alveoli

Alveolar pockets

Vessel

Respiratory bronchiole

Simple cuboidal

Ad

Slot 5.19: Alveoli

Septa

Pulmonary macrophage

Slot 5.20: Fetal lung, prior to expansion

Slot 5.22: Lung of non-smoker

• Note: macrophages have little particulate matter

Pulmonary Macrophages

Slot 5.23: Lung of smoker

• Note: pulmonary Note: pulmonary macrophages full of macrophages full of particulate matter (darker particulate matter (darker staining)staining) Pulmonary

macrophages