skin condition associated with disease
TRANSCRIPT
Skin conditiond and associated disease
Acanthosis Nigricans-insulin resistance (Diabetes Mellitus, PCOS)-GIT malignancy
AN can be divided into benign and malignant forms -Benign AN :
-younger individuals
-associated with insulin-resistant states (eg:DM,obesity,PCOS) increased levels of insulin and/or insulin-like growth factor are thought to stimulate epidermal and dermal proliferation.
-Similarly,skin tags(acrochondrons),which are pedunculated outgrowths of normal skin,are also commonly present on regions,affected byn AN
Malignant AN
underlying neoplasms ,especially of the GIT and genitourinary tracts.
The sudden appearance of such skin changes in middle-aged or elderly pt is suggestive of underlying malignancy.
These patient are not obese(but instead may have lost weight) and lesions can occur in uncomon areas(eg.mucous membrances, palms,soles.)
Answer : E- Polycystic ovarian sydrme
Porphyria Cutanea Tarda
PCT is a blistering skin disease of sun-exposed areas in those with a history of : Liver disease (hepatitis C,
alcoholism) Estrogen use Iron overload (hemochromatosis)
Look for involvement of thebacks of the hands and the
face.
PCT is a hypersensitivityof the skin to abnormalporphyrins when they areexposed to light.
Minimal hypertrichosis and erosions with crusts over the left side of the face
Diagnostic Tests/Treatment
The most accurate diagnostic test is increased uroporphyrins in a 24-hour urine collection.
It is a deficiency of uroporphyrin decarboxylase activity.
Correct the underlying cause (stop alcohol, stop estrogens) and remove iron with phlebotomy.
Bright pink fluorescence on woods lamp examination
Seborrheic Dermatitis (Dandruff)
Seborrheic dermatitis is a hypersensitivity reaction to a dermal infection with noninvasive dermatophyte organisms.
This is why both topical steroids (hydrocortisone, alclometasone) and antifungal agents (ketoconazole) are useful.
It is increased in:• AIDS• Parkinson disease
The term seborrheic is synonymous with benign
Dermatitis herpetiformis- celiac disease
Multiple skin tags
Insulin resistance Pregnancy Crohn disease(perianal)
Explosive onset of Seborrheic keratoses –GIT malignancy
Seborrheic Keratoses
These lesions are extremely common in the elderly.
They are hyperpigmented lesions commonly referred to as liver spots. They give a "stuck on" appearance.
Although they may look like melanoma to some people, seborrheic keratoses have no premalignant potential. They do not transform into melanoma.
They are removed with cryotherapy, surgery, or laser for cosmetic reasons.
Pyoderma gangrenosum - IBD