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Skin & Bio Research
Scientific Beauty SubstantiationGlobal leader in Asian cosmetics testing
Ellead is a clinical and biotechnology company which is specialized in cosmetics and food supplement. Since 2001, Ellead has been performing clinical studies according to protocols for efficacy, safety, sensory tests of cosmetics, cosmeceuticals, and functional food products with great accuracy and reliability.
• Good Laboratory Pratice (GLP) certified by Korea Ministry of Food and Drug Safety
• ISO 9001: 2008 certification
• IRB (Institutional Review Board) registration
2016
2015
2014
2013
2012
2011
2007
2006
2005
2004
2003
2001
- Certified Good Laboratory Practice (GLP) by MFDS - Received Best Work Environment Award
- Establishment of in vitro research center at Osong, Korea - Development of improved evaluation method of UVA sunscreen (MFDS Cosmetic Efficacy Evaluation Guideline)- Validation of in vitro UVA evaluation method (MFDS)
- Presentation on Functional Cosmetics in Korea at One Asia Beauty Forum in China 2014- 2014 Venture Industry Activation Merit Award (received MOTIE Minister Award)- Developed evaluation method for irritation test using artificial skin- Development of evaluation method for edema improvement and skin blood flow (MFDS Cosmetic Efficacy Evaluation Guideline)
- Registered IRB with Korea Centers for Disease Control and Prevention - Development of evaluation method for dark circle alleviation (KFDA Cosmetic Efficacy Evaluation Guideline)
- Development of evaluation method for proper acne skin care (KFDA Cosmetic Efficacy Evaluation Guideline)
- Changed CI and opened second R&D Center- Registered IRB with US Food and Drug Administration - Received Million Dollar Export Award
- Field trip of cosmetic officialdom of China, Thailand, Philippines and Indonesia
- Certified as technically innovative (INNO-BIZ) company- Development of evaluation method for water-resistant sunscreen of SPF (KFDA Cosmetic Efficacy Evaluation Guideline) - Certified as venture company
- Acquired ISO 9001:2000 - Technology exchange with “DermExpert”
- Certified as the industry’s first R&D center by Korean Industrial Technology Promotion Association
- Established “Ellead”
History
Ellead | Skinn & Bio Research
Core Values
Sophistication
Trust
Our dermatologists have various clinical experiences and our skilled researchers provide the most suitable testing method to meet the demands of our customers. We perform clinical trials in accordance with Good Clinical Practice (GCP) under the supervision of our dermatologists.
AdvanceIn order to correspond with the current rapidly changing market, Ellead strives to extend its business spectrum to provide total clinical evaluation service focused on customer satisfaction by building a network with research and development centers and universities. We continue to develop new instru-ments, software and studies to maintain our advanced technologies.
RelianceEllead has been acknowledged for producing reliable and accurate results and accredited by the government. Many research results were presented at academic conferences. Now multinational corporations trust our research results and maintain a business partner.
• Standard Operating Procedures (SOP) set to meet various international regulations
• Studies conducted based on GCP guideline
• Ellead Institutional Review Board (IRB) registered with Korea and US FDA
• Quality Assurance system for high reproducibility and accuracy
• State of the art GLP compliant facilities
• Dermatologist-controlled studies
• Patented scientific photography system
• Multiple instruments to ensure reliability
• Various protocols tailored to each customer’s needs
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Quality Management
Efficacy / Safety / Sensory Evaluation
Testing Overview
Testing for
- Cosmetic products
- Active ingredients
- Raw materials
- Hair care products
- Toiletries
- Household products
- Functional foods
- Cosmetic devices
Ellead | Skin & Bio Research
Clinical test forEfficacy evaluation
Clinical test forSafety evaluation
- Functional cosmetics- Functional foods- Quasi-drugs
Service fields
test for cosmeticingredients and products
- Cytotoxicity test- Efficacy evaluation
- Primary patch test- Repeated insult patch test- Cumulative irritation test
Clinical test
In v
itro
effic
acy t
est
Safety test
In vitro
CLINICAL EVALUATION
Clinical safety test
Patch testSafety testing of cosmetic ingredients and finished products is of utmost importance. A variety of patch test designs are available to test for irritation or sensitization in the product development process.
Primary patch test
Repeated insult patch test (RIPT)
Cumulative irritation test (CIT)
Comedogenicity testComedogenic potential is tested by counting the number of comedones.
Follicular biopsy test on the back
Home use test with visual assessment
In-use testIn-use test is designed to test your product on the consumer’s view and dermatologist examination.
Self-assessment questionnaires (satisfaction & tolerance)
Adverse reaction
Eye irritation testEye irritation test is conducted in collaboration with ophthalmologist to study the level of sting and irritation in the eye that occur from contacting a product.
Efficacy / Safety / Sensory Evaluation
In Korea, anti-wrinkle, whitening and sunscreen products are categorized as functional cosmetics
Anti-aging
Anti-wrinkle*
Skin whitening*
Sunscreen (SPF, PA, Waterproof, Sweatproof)*
Skin hydration & lasting effect
Trans-epidermal water loss (TEWL)
Skin barrier recovery
Skin elasticity · Dermal density
Facial lifting
Skin sebum · Blackhead
Cleansing (Pore, Make-up)
Skin desquamation · Turn over
Skin gloss · Translucency
Dark circle
Cellulite · Puffiness · Stretch mark
Skin temperature
Microcirculation
Anti-microbial (Handwash)
Ellead | Skin & Bio Research
Clinical efficacy test
Skin careClinical efficacy tests are conducted to test and substantiate the product’s intended purposes. We offer a wide range of tailored studies to claim your product’s efficacy and to maximise its impact in the marketplace using the latest equipment and technology.
Various test areas
Anti-wrinkle
Whitening
Before After
Available standards:
CLINICAL EVALUATION
Clinical efficacy test
SPF PA Water resistance In vitro
MFDS
ISO 24444
FDA final rule (2011)
Cosmetics Europe
CFDA
MFDS
ISO 24442
JCIA
CFDA
MFDS water resistance
FDA final rule (2011)
Colipa water resistance
CFDA
ISO 24443
FDA final rule (2011)
SunscreenWe have many Multiport Solar Simulators dedicated to each SPF, PA and water resistance test to offer multiple product testing according to the desired standard listed below.
We also offer in vitro SPF and PA test according to ISO 24443 and US FDA standards.
Efficacy / Safety / Sensory Evaluation
Skin temperature
Facial lifting Dermal density
Cheek sagging
Before After
Color durability and homogeneity
Hydration of lips
Eyelash curling
Ellead | Skin & Bio Research
Clinical efficacy test
Make-upA variety of makeup products from foundations to eye makeup products can be tested to prove their efficacies on improving skin tone and lightening as well as for long lasting coverage, waterproof, curling and volumizing effect.
Hydration
Desquamation
Roughness
Lip careLip care products are applied topically to help moisturize and relieve skin dryness and chapping, and are tested for such claims.
Makeup color lasting effect · Homogeneity
Makeup coverage & lasting effect
Mascara & eyeliner waterproof effect
Eyelash curling & volume
Nail color lasting effect
Before After Overlay
Before After
CLINICAL EVALUATION
Clinical efficacy test
Efficacy / Safety / Sensory Evaluation
Hair gloss
Hair damage care Scalp desquamation
Hair growth Hair volume
Hair careA wide range of hair product testing is available including hair growth studies with phototrichogram as well as hair condition, color, strength and style testing services.
Hair growth
Hair damage
Gloss · Hydration
Tensile strength · Elasticity
Curling · Volume
Dye color durability
Scalp sebum · Desquamation
Scalp hydration · Elasticity
Before After
Before After Before After Before After
Intimate hygieneIntimate hygiene products are tested in collaboration with gynecologist and dermatologist.
Vaginal health grading
pH measurement
Skin hydration
Self-assessment
Ellead | Skin & Bio Research
Clinical efficacy test
Oral careOral care products, such as tooth paste or mouthwash, can be tested for tooth whitening effect, oral hygiene and breath odor.
Tooth whitening
Oral hygiene
Breath odor
Acne study
Quasi-drugsQuasi-drugs are the products that have minimal to moderate pharmacologic (cosmeceutical) activity. The efficacy tests for quasi-drugs are conducted according to available guidelines.
Hair loss
Acne
Atopic dermatitis
Anti-microbial (Sanitizer)
Deodorant
Dandruff
Before After
CLINICAL EVALUATION
Functional foods
Efficacy / Safety / Sensory Evaluation
Visual assessment
Skin hydration · Wrinkle · Elasticity
Blood examination · Urine examination
Skin careEfficacy claims such as anti-wrinkle, whitening and hydration effects and safety of food supplements are tested after the approval of Ellead Institutional Review Board.
GLP study (certified by MFDS)
Skin irritation test Ellead has acquired Good Laboratory Practice (GLP) certification by Korea Ministry of Food and Drug Safety (MFDS) for in vitro Skin Irritation: Reconstructed Human Epidermis Test Method (OECD TG439).
in vitro
Ellead | Skin & Bio Research
In vitro test
In vitro test
MTT assay
WST-1 assay
Alamar blue assay
Cytotoxicity & cell viability Nitric oxide inhibition assay
Cytokine inhibition assay (IL-6, TNF-α)
Protein inhibition assay (COX-2, PGE2)
Anti-inflammation
DPPH radical scavenging assay
ORAC (Oxygen radical absorbance capacity) assay
Total polyphenol quantification assay
ROS (Reactive oxygen species) scavenging assay
Anti-oxidant mRNA expression analysis
(Aquaporin, Hyaluronan synthase, Involucrin, Filaggrin)
Protein expression analysis (Involucrin, Filaggrin)
Moisture & Skin barrier
Collagen synthesis assay
Collagenase inhibition assay (MMP-1, MMP-3)
Anti-wrinkle Skin Irritation
: Reconstructed Human Epidermis Test
Skin absorption test using diffusion cell
3T3 NRU phototoxicity test
Alternatives to animal testing
Elastase inhibition assay
Elasticity
mRNA expression analysis by RT-PCR, RT-qPCR
Protein expression analysis by Western blot
Others tyrosinase inhibition assay
DOPA oxidation inhibition assay
Melanogenesis inhibition assay
Whitening
testing is essential in raw material / active ingredient development. Ellead offers various efficacy and safety tests customized to your needs at our new Ellead Osong research center dedicated solely for testing.
in vitro
in vitro
in vitro
in vitro
in vitro
in vitro
CLINICAL EVALUATION
Ellead Co., Ltd. www.ellead.com[HQ] 325, Hwangsaeul-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea 13590Tel: +82-31-709-9030 | Fax: +82-31-703-9071 | E-mail: [email protected]
[BRANCH] Venture center II, 194-41, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, Republic of Korea 28160 Tel: +82-43-715-5371 | Fax: +82-43-715-5377 | E-mail: [email protected]
Sophistication Advance Reliance
• ISO 9001:2008 Certified• GLP (Good Laboratory Practice) Certified• IRB (Institutional Review Board) Registered