Single vs Dual HER2 Blockade for Metastatic HER2-Positive Breast Cancer

Program Goals

Changes to the Standard of Care for HER2-Positive Disease

CLEOPATRA Trial Results

CLEOPATRAUpdated Overall Survival Analysis

Administering Dual HER2 Blockade

Are All Patients Candidates for Dual HER2 Blockade?

Pertuzumab /Trastuzumab /DocetaxelSafety Profile

Approaches in Different Scenarios

Neoadjuvant Therapy

Surgery in a Patient With Stage IV Breast Cancer

Investigational Trials

Abbreviations

References

References (cont)

References (cont)