Simon McAdoo APC – Regal Processors Limited

The Lauridsen Group Companies

Feed ingredients and user-ready

consumer products that

support animal health.

Meat by-products for the food, pet food,

feed and pharmaceutical

industries.

Processed poultry by-products.

Clinically safe biotherapeutics

that address unmet needs.

High-purity plasma fractions for the diagnostic, life

science research, biopharmaceutical and

veterinary vaccine industries.

Deproteinized whey for global bakery, beverage, confectionery, dairy and prepared foods markets.

Functional protein solutions including stocks, broths, flavors, fats, health and

nutrition and fish products.

NORTH AMERICA Calgary, Alberta Vercheres, Quebec Ankeny, Iowa [Global Headquarters] Boone, Iowa Denison, Iowa Dubuque, Iowa Selma, North Carolina Sublette, Kansas

LATIN AMERICA Buenos Aires, Argentina Araçatuba, Brazil Chapecó, Brazil San Luis, Brazil

EUROPE Craigavon, Northern Ireland Doncaster, England Poznan, Poland Granollers, Spain [European Headquarters] Villarrobledo, Spain

ASIA PACIFIC Dezhou, China Hebei, China Lin Yi, China Tokyo, Japan [Sales Office]

APC GLOBAL PRESENCE

Craigavon, Northern Ireland

Doncaster, England

Poznan, Poland

Granollers, Spain • European Headquarters

Villarrobledo, Spain

APC Europe – American Protein Corporation

APC

• Was founded in the USA in 1981

• Is the world’s largest producer of spray-dried plasma proteins

• Evolved from manufacturing plasma used as performance enhancers in swine diets to specializing in protein fractionation

• Has a product line of nearly 20 different ingredients and complete end-user products

European Production Facilities

REGAL PROCESSORS LIMITED – located in County Armagh

Regal Processors

In existence for >40yr’s, part of the APC group for the past 23yrs.

Regal Processors Ltd. process over 90% of the available bovine and porcine blood on the island of Ireland, sourced from EC approved slaughterhouses, for the manufacture of spray dried animal blood products – functional proteins.

What we do: APC Spray Dried Proteins

Functional Plasma Protein

Whole Blood

Highly Digestible Blood Cells

AP820 AP301

Manufacturing Process Summary

Q/A steps

Dedicated tankers

Storage tanks

Concentration

Spray-drier Staging

Bagging

Category 3 blood from bovine and porcine approved for the manufacturing of blood products according to R1069/2009 anticoagulant

Centrifuge

RBC

Plasma

Chiller

Storage tanks

Further processing

storage

Finished products include spray dried bovine plasma, porcine plasma, bovine haemoglobin (red cells), porcine haemoglobin (red cells) and whole blood.

ISO 9001

ISO 14001

GMP - feed materials

HACCP

Standards include:

USE OF BLOOD PRODUCTS AS FEED ADDITIVE FOR ANIMAL CONSUMPTION AND INDUSTRIAL USE

APC is the world’s largest producer of spray dried blood & plasma proteins for feed and industrial applications – approximately 75% worldwide.

Applications in the following:

Animal Health & Nutrition Swine Ruminant Poultry Companion Aquaculture Industrial Applications Plywood Fertilizer Cement Plaster/Stucco

The EC Regulations regarding the manufacture of spray dried blood products are enforced nationally by DAERA NI – Department of Agriculture, Environment and Rural Affairs for Northern Ireland.

LEGISLATION

LEGISLATION

REGULATION (EC) No 1069/2009 animal by-products and derived products not

intended for human consumption

Category 3 materials – Article 10 (a) (…) parts of animals slaughtered (…) and which are fit for human consumption (…) but are not intended for human consumption for commercial reasons; “Blood post-mortem inspected and fit for human: food grade” (b) (i) (…) parts of animals which are rejected as unfit for human consumption (…) but which did not show any signs of disease communicable to humans or animals (…) originating (…) from animals that have been slaughtered in a slaughterhouse and were considered fit for slaughter for human consumption following an ante-mortem inspection “Blood ante-mortem inspected”

(EC) No 999/2001 as regards prohibitions concerning animal feeding of processed animal proteins derived

from non-ruminant animals (latest amendment 56/2013)

II. Derogations from the prohibitions provided for in Article 7(1) and (2)(…) A. The prohibitions provided for in Article 7(1) and (2) shall not

apply to: (a) the feeding to farmed animals of (…):

(iv) hydrolysed proteins derived from parts of non-ruminants and from ruminant hides and skins;

(b) the feeding to non-ruminant farmed animals of(…):

(iii) blood products derived from non-ruminants; (iv) processed animal proteins, other than fishmeal, derived from non-ruminants (…) (includes blood meal)

Implemented by EC Reg. 142/2011

LEGISLATION

REGULATION (EC) No 142/2011 animal by-products and derived products not intended for human consumption

Porcine Blood Products

1. Raw material Only porcine blood referred to in Article 10(a) and Article 10(b)(i) of Regulation (EC) No 1069/2009 may be used for the production of blood products. 2. Species of destination

SWINE FUR POULTRY AQUA PETFOOD

LEGISLATION

REGULATION (EC) No 142/2011 animal by-products and derived products not intended for human consumption

Bovine/ Mixed Species Blood Products

1. Raw material Only bovine blood referred to in Article 10(a) and Article 10(b)(i) of Regulation (EC) No 1069/2009 may be used for the production of blood products. 2. Species of destination

3. Exceptions in non-EU countries

FUR PETFOOD

ADDITIONAL SAFETY STEPS

EAPA (European Animal Protein Association) Code of Practice:

Porcine blood products destined for swine feeds manufacturing

1. Minimum 80ºC outlet temperature 2. Minimum 180ºC inlet temperature 3. Hold plasma and red cells going to swine for at least 2 weeks @ minimum

20ºC 4. Water activity below 0.6 and moisture content less than 8 % 5. Keeping appropriate records

S18

Key Business Strategies

Research & Product Development Leadership

APC’s staff of researchers and product developers has published more than 400 scientific papers relating to the efficacy and use of blood

and plasma proteins.

COW SWINE FUR

POULTRY AGRICULTURE AQUA INDUSTRIAL

PETFOOD

WE ARE BACKED BY SOUND SCIENCE

• More than 400 peer-reviewed studies over 30 years across species demonstrate effectiveness

APC R&D Team

• 15 People in R&D and Technical Service. • 2 R&D Groups : USA group and European group • Work closely with Universities and External Research

groups on both sides of the ocean.

Spanish R&D and Pilot Plant Facilities

LAB (Lauridsen Advance Building)

R&D Project Focus

Projects Oriented to Maintain /Expanding Actual Business

Projects Oriented to Develop a New Product/New Process

Biosafety Basic Research

Publications related with the Biosafety of Blood Products

R&D Project Focus

S12

R&D Projects

APC R&D Projects

Biosafety Projects •Virus and bacteria safety

trials

Expanding Actual Business / Incremental Innovations • Swine •Wet Pet Food •Dry Pet Food •Calves

New Applications / New Products /Breakthrough Innovations •Dairy Cows •Aqua •Poultry • Field trials • SDAP in antibiotic free diets.

Basic Research /Breakthrough Innovations •Mode of Action •Hydrolyzed Products •Plasma Fractionation • Industrial Projects

Other Activities in The R&D Department During The Year 2017 • 5 Published/Accepted articles in Peer-Review J

• Crenshaw et al. JSHP 25(1):10-18. SDP in pigs positive for PRRS • Blázquez et al. PLoS ONE 12(4):e0175289. UV effect on Salmonella

• Bach et al.. AFST 231 :89-96. Use of Peptein in Dairy Cows

• Crenshaw et al. Plasma vs alternative proteins • Morrison et al. J Dairy Sci. 100(6):1-13

• 6 Articles submitted in Peer-Rev. J.

• Polo & Matas. Use of Pepton in cherry tomato

• Blázquez et al. UV and SD effect on E. coli • Blázquez et al. SD effect on Salmonella strains

• Campbell et al. Feeding UV-SDPP to naïve pigs

• Lee et al., Plasma effect on Dairy Cows • Pérez-Bosque et al. Aging papers

• 21 Abstract/papers in specialized Congress

• ESPHM 2017 – 2 Abstracts and Posters (Biosafety) • AASV 2017– 2 Abstract and Oral presentation (Swine)

• AASV 2018 – 1 Absrtract submitted and accepted (Biosafety)

• ADSA 2017 – 2 Abstracts and Posters (Dairy Cows) • ESS 2017 – 1 Abstract (Horses)

• ISIN 2017 – 2 Abstract (MOA)

• Microbiota Congress – 1 Abstract (MOA)

• WAS – 1 Abstract (Aqua)

• Aquaculture Europe – 1 Abstract (Aqua) • Leman Conference – 1 Abstract (Biosafety)

• IPPE 2018 – 1 Abstract submitted (Poultry)

• AMENA 2017: 2 Abstract (Swine & Poultry) • Gut Health 2017: 1 Abstract submitted (Swine)

• ABRAVES 2017 – 1 Abstract (swine)

• MW ASAS 2018 – 2 Abstract (Plasma with Formaldehyde)

• 17 White Papers / Articles in specialized magazines • Digestibility of Turkey blood

• Plasma in poultry. New Leeson paper

• 4 Tech Notes about use of plasma in Aqua • 4 Tech Notes about the use of plasma in swine

• 2 Discoveries related with the use of plasma in swine.

• Pepton in Olive trees • SDP in wet cat food improves digestibility

• Use of SDP in farm with problems with PCV2 and PRRS

THE FUTURE – THREATS/OPPORTUNITIES

• OPPORTUNITITES:

• ATB REPLACEMENT • BAN ON ZINC OXIDE (ZnO)

• TREATS:

• BREXIT??? • ANIMAL DISEASE AND SUBSEQUENT LEGISLATION – think about the impact of BSE in the

past! What about ASF in CEE (Poland, Russia, Belarus, Romania etc) • RETAILER BAN ON THE USE OF ANIMAL PROTEINS.

Meat Association and Retailers ban on the use of Animal Proteins

For further information on our company, our

products, or the science backing up as the leader in blood products’ research, you can:

Visit us at functionalproteins.com/europe

Contact us at: info@apc-europe.com Call us at: +34 938 615 060

THANK YOU FOR YOUR ATTENTION.