sifi group sifi group presentationpresentation · 2014-05-20 · focus on focus on cataract...
TRANSCRIPT
SIFI Group SIFI Group SIFI Group SIFI Group SIFI Group SIFI Group SIFI Group SIFI Group PresentationPresentationPresentationPresentationPresentationPresentationPresentationPresentation
SIFI aims SIFI aims SIFI aims SIFI aims SIFI aims SIFI aims SIFI aims SIFI aims at becoming an international at becoming an international at becoming an international at becoming an international at becoming an international at becoming an international at becoming an international at becoming an international EyeCareEyeCareEyeCareEyeCareEyeCareEyeCareEyeCareEyeCare company company company company company company company company
Mission
SIFI aims SIFI aims SIFI aims SIFI aims SIFI aims SIFI aims SIFI aims SIFI aims at becoming an international at becoming an international at becoming an international at becoming an international at becoming an international at becoming an international at becoming an international at becoming an international EyeCareEyeCareEyeCareEyeCareEyeCareEyeCareEyeCareEyeCare company company company company company company company company
enabling enabling enabling enabling enabling enabling enabling enabling practitioners to manage a wide range of practitioners to manage a wide range of practitioners to manage a wide range of practitioners to manage a wide range of practitioners to manage a wide range of practitioners to manage a wide range of practitioners to manage a wide range of practitioners to manage a wide range of
ophthalmic diseases ophthalmic diseases ophthalmic diseases ophthalmic diseases ophthalmic diseases ophthalmic diseases ophthalmic diseases ophthalmic diseases , from prevention through diagnosis, , from prevention through diagnosis, , from prevention through diagnosis, , from prevention through diagnosis, , from prevention through diagnosis, , from prevention through diagnosis, , from prevention through diagnosis, , from prevention through diagnosis,
pharmacological and /or surgical treatment, pharmacological and /or surgical treatment, pharmacological and /or surgical treatment, pharmacological and /or surgical treatment, pharmacological and /or surgical treatment, pharmacological and /or surgical treatment, pharmacological and /or surgical treatment, pharmacological and /or surgical treatment,
including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.including rehabilitation.
SIFI GroupSIFI GroupSIFI GroupSIFI GroupSIFI GroupSIFI GroupSIFI GroupSIFI Group
Pharma BusinessPharma Business
SIFI SpASIFI SpASIFI SpASIFI SpA
Eyelab SrlEyelab SrlEyelab SrlEyelab SrlOftafarmaOftafarmaOftafarmaOftafarma
Romania SrlRomania SrlRomania SrlRomania Srl
LaboratoriosLaboratoriosLaboratoriosLaboratorios SIFI SIFI SIFI SIFI de Mexico S.A. de Mexico S.A. de Mexico S.A. de Mexico S.A.
de de de de C.V.C.V.C.V.C.V.
SIFI SIFI SIFI SIFI MedtechMedtechMedtechMedtech SrlSrlSrlSrl
SIFI SIFI SIFI SIFI RealRealRealReal Estate SrlEstate SrlEstate SrlEstate Srl
de de de de C.V.C.V.C.V.C.V.
OrganisationOrganisationOrganisationOrganisationOrganisationOrganisationOrganisationOrganisation
GeneralGeneralGeneralGeneral ManagerManagerManagerManager
QualityQualityQualityQuality AssuranceAssuranceAssuranceAssurancePlanning, Planning, Planning, Planning, ControlControlControlControl & & & &
OrganisationOrganisationOrganisationOrganisation
Finance & Finance & Finance & Finance & AdministrationAdministrationAdministrationAdministration PurchasingPurchasingPurchasingPurchasing OfficeOfficeOfficeOffice
Business & Portfolio Business & Portfolio Business & Portfolio Business & Portfolio DevelopmentDevelopmentDevelopmentDevelopment
Manufacturing Manufacturing Manufacturing Manufacturing OperationsOperationsOperationsOperations(QP)(QP)(QP)(QP)
Market AccessMarket AccessMarket AccessMarket Access
From a domestic From a domestic From a domestic From a domestic From a domestic From a domestic From a domestic From a domestic leader …leader …leader …leader …leader …leader …leader …leader …
BrandBrandBrandBrandBrandBrandBrandBrand positioningpositioningpositioningpositioningpositioningpositioningpositioningpositioning
Strong company brand Strong company brand Strong company brand Strong company brand Strong company brand Strong company brand Strong company brand Strong company brand image:image:image:image:image:image:image:image:
� Almost 80 years Almost 80 years Almost 80 years Almost 80 years of history and of history and of history and of history and
excellence excellence excellence excellence
� Broad product portfolio that meets Broad product portfolio that meets Broad product portfolio that meets Broad product portfolio that meets
most ophthalmologists needsmost ophthalmologists needsmost ophthalmologists needsmost ophthalmologists needs
� High level of serviceHigh level of serviceHigh level of serviceHigh level of service
� Top class educational programsTop class educational programsTop class educational programsTop class educational programs
Independent Independent Independent Independent Independent Independent Independent Independent mmmmmmmmarket research arket research arket research arket research arket research arket research arket research arket research
confirms confirms confirms confirms confirms confirms confirms confirms (*)(*)(*)(*)(*)(*)(*)(*)::::::::
� ‘most ‘most ‘most ‘most Trusted Brand in Trusted Brand in Trusted Brand in Trusted Brand in Italy’Italy’Italy’Italy’
� ‘ideal ‘ideal ‘ideal ‘ideal ophthalmic ophthalmic ophthalmic ophthalmic company’company’company’company’
� ‘... ‘... ‘... ‘... that best meets their that best meets their that best meets their that best meets their needs’needs’needs’needs’
� ‘best ‘best ‘best ‘best quality of product quality of product quality of product quality of product detailing’detailing’detailing’detailing’
� ‘best ‘best ‘best ‘best trained trained trained trained Reps’Reps’Reps’Reps’
“New vision” “New vision” “New vision” “New vision”
since since since since 2005200520052005
… to a global integrated … to a global integrated … to a global integrated … to a global integrated … to a global integrated … to a global integrated … to a global integrated … to a global integrated Eye Eye Eye Eye Eye Eye Eye Eye Care Care Care Care Care Care Care Care companycompanycompanycompanycompanycompanycompanycompany
� Top class educational programsTop class educational programsTop class educational programsTop class educational programs
(*) IMS Oftaclient survey 2007/2011/2012
Focus on OphthalmologyFocus on OphthalmologyFocus on OphthalmologyFocus on OphthalmologyFocus on OphthalmologyFocus on OphthalmologyFocus on OphthalmologyFocus on Ophthalmology
DistinctiveDistinctiveDistinctiveDistinctiveDistinctiveDistinctiveDistinctiveDistinctive featuresfeaturesfeaturesfeaturesfeaturesfeaturesfeaturesfeatures
Integrated Integrated Integrated Integrated Integrated Integrated Integrated Integrated business modelbusiness modelbusiness modelbusiness modelbusiness modelbusiness modelbusiness modelbusiness model
Product portfolio strategy based on Product portfolio strategy based on Product portfolio strategy based on Product portfolio strategy based on Product portfolio strategy based on Product portfolio strategy based on Product portfolio strategy based on Product portfolio strategy based on
““““““““Open InnovationOpen InnovationOpen InnovationOpen InnovationOpen InnovationOpen InnovationOpen InnovationOpen Innovation””””””””
Strong Pharma Strong Pharma Strong Pharma Strong Pharma Strong Pharma Strong Pharma Strong Pharma Strong Pharma businessbusinessbusinessbusinessbusinessbusinessbusinessbusinessStrong Pharma Strong Pharma Strong Pharma Strong Pharma Strong Pharma Strong Pharma Strong Pharma Strong Pharma businessbusinessbusinessbusinessbusinessbusinessbusinessbusiness
Medical Technologies business Medical Technologies business Medical Technologies business Medical Technologies business Medical Technologies business Medical Technologies business Medical Technologies business Medical Technologies business
set set set set set set set set for growthfor growthfor growthfor growthfor growthfor growthfor growthfor growth
SIFI SpASIFI SpASIFI SpASIFI SpASIFI SpASIFI SpASIFI SpASIFI SpA SIFI MEDTECH SrlSIFI MEDTECH SrlSIFI MEDTECH SrlSIFI MEDTECH SrlSIFI MEDTECH SrlSIFI MEDTECH SrlSIFI MEDTECH SrlSIFI MEDTECH Srl
Scope Scope Scope Scope Scope Scope Scope Scope ofofofofofofofof businessbusinessbusinessbusinessbusinessbusinessbusinessbusiness
Development,Development,Development,Development,
Manufacturing,Manufacturing,Manufacturing,Manufacturing,
M&SM&SM&SM&S of:of:of:of:
Development,Development,Development,Development,
M&SM&SM&SM&S ofofofof::::
Development,Development,Development,Development,
RegistrationRegistrationRegistrationRegistration,,,,
Manufacturing,Manufacturing,Manufacturing,Manufacturing,
M&SM&SM&SM&S ofofofof::::
Development,Development,Development,Development,
M&SM&SM&SM&S of:of:of:of:
RxRxRxRx, OTC,, OTC,, OTC,, OTC,
MedicalMedicalMedicalMedical
DevicesDevicesDevicesDevices
(CE Mark)(CE Mark)(CE Mark)(CE Mark)
NutraceuticalNutraceuticalNutraceuticalNutraceutical,,,,
CosmeceuticalsCosmeceuticalsCosmeceuticalsCosmeceuticals
IntraIntraIntraIntra----OcularOcularOcularOcular
LensesLensesLensesLenses ((((IOLsIOLsIOLsIOLs))))
& & & &
DiagnosticDiagnosticDiagnosticDiagnostic
EquipmentEquipmentEquipmentEquipment
DisposablesDisposablesDisposablesDisposables,,,,
MedicalMedicalMedicalMedical
DevicesDevicesDevicesDevices
� 50+ 50+ 50+ 50+ pharmaceuticalpharmaceuticalpharmaceuticalpharmaceutical formsformsformsforms
� ProprietaryProprietaryProprietaryProprietary and and and and inininin----licensedlicensedlicensedlicensed productsproductsproductsproducts
� BFS manufacturing BFS manufacturing BFS manufacturing BFS manufacturing capabilitycapabilitycapabilitycapability
� Focus on Focus on Focus on Focus on CataractCataractCataractCataract and and and and VisualVisualVisualVisual
AbilitiesAbilitiesAbilitiesAbilities measurementsmeasurementsmeasurementsmeasurements
� ProprietaryProprietaryProprietaryProprietary IOLsIOLsIOLsIOLs and and and and diagnosticdiagnosticdiagnosticdiagnostic
Product Product Product Product Product Product Product Product offeringofferingofferingofferingofferingofferingofferingoffering
SIFISIFISIFISIFISIFISIFISIFISIFIMedtechMedtechMedtechMedtechMedtechMedtechMedtechMedtech
SrlSrlSrlSrlSrlSrlSrlSrl
IOLsIOLsIOLsIOLs
OVDsOVDsOVDsOVDsVisionVisionVisionVision
testerstesterstesterstesters
Combinations Combinations Combinations Combinations
AntiAntiAntiAnti----InfectivesInfectivesInfectivesInfectives
+ Steroids+ Steroids+ Steroids+ SteroidsTear Tear Tear Tear
supplements & supplements & supplements & supplements &
wound wound wound wound healinghealinghealinghealing
AntiAntiAntiAnti----
NutraceuticalsNutraceuticalsNutraceuticalsNutraceuticals &&&&
NeuroprotectorsNeuroprotectorsNeuroprotectorsNeuroprotectors
SIFI SIFI SIFI SIFI SIFI SIFI SIFI SIFI SpASpASpASpASpASpASpASpA
� BFS manufacturing BFS manufacturing BFS manufacturing BFS manufacturing capabilitycapabilitycapabilitycapability
� TollTollTollToll Manufacturing Manufacturing Manufacturing Manufacturing
� ProprietaryProprietaryProprietaryProprietary IOLsIOLsIOLsIOLs and and and and diagnosticdiagnosticdiagnosticdiagnostic
equipmentequipmentequipmentequipment, , , , inininin----licensedlicensedlicensedlicensed disposablesdisposablesdisposablesdisposables
� StateStateStateState----ofofofof----thethethethe----ArtArtArtArt manufacturing manufacturing manufacturing manufacturing plantplantplantplant
Imaging Imaging Imaging Imaging
diagnosticsdiagnosticsdiagnosticsdiagnostics
SrlSrlSrlSrlSrlSrlSrlSrl
CataractCataractCataractCataract
disposablesdisposablesdisposablesdisposables
AntiallergicsAntiallergicsAntiallergicsAntiallergicsAntiAntiAntiAnti----
InfectivesInfectivesInfectivesInfectives
AntiAntiAntiAnti----
GlaucomaGlaucomaGlaucomaGlaucomaNSAIDsNSAIDsNSAIDsNSAIDs
SIFI SIFI SIFI SIFI SIFI SIFI SIFI SIFI SpASpASpASpASpASpASpASpA
CorticosteroidsCorticosteroidsCorticosteroidsCorticosteroids
�SIFI SIFI SIFI SIFI is a leader in Italy, the is a leader in Italy, the is a leader in Italy, the is a leader in Italy, the world’s 5world’s 5world’s 5world’s 5th th th th
largest largest largest largest ophthalmic marketophthalmic marketophthalmic marketophthalmic market
Global market Global market Global market Global market Global market Global market Global market Global market coveragecoveragecoveragecoveragecoveragecoveragecoveragecoverage
largest largest largest largest ophthalmic marketophthalmic marketophthalmic marketophthalmic market
�The Group of companies employs The Group of companies employs The Group of companies employs The Group of companies employs a a a a staff of staff of staff of staff of staff of staff of staff of staff of
about 350about 350about 350about 350about 350about 350about 350about 350 and generates and generates and generates and generates turnover from turnover from turnover from turnover from
domestic sales and international Pharma domestic sales and international Pharma domestic sales and international Pharma domestic sales and international Pharma
marketsmarketsmarketsmarkets
�The Group HQ is located 20 km from The Group HQ is located 20 km from The Group HQ is located 20 km from The Group HQ is located 20 km from
Catania, Italy, where Catania, Italy, where Catania, Italy, where Catania, Italy, where R&D and R&D and R&D and R&D and R&D and R&D and R&D and R&D and
HQ/Production siteHQ/Production siteHQ/Production siteHQ/Production site SubsidiarySubsidiarySubsidiarySubsidiary Distributors/PartnersDistributors/PartnersDistributors/PartnersDistributors/Partners
Catania, Italy, where Catania, Italy, where Catania, Italy, where Catania, Italy, where R&D and R&D and R&D and R&D and R&D and R&D and R&D and R&D and
manufacturing facilities for Pharmaceuticals manufacturing facilities for Pharmaceuticals manufacturing facilities for Pharmaceuticals manufacturing facilities for Pharmaceuticals manufacturing facilities for Pharmaceuticals manufacturing facilities for Pharmaceuticals manufacturing facilities for Pharmaceuticals manufacturing facilities for Pharmaceuticals
and Medical Technologies are locatedand Medical Technologies are locatedand Medical Technologies are locatedand Medical Technologies are locatedand Medical Technologies are locatedand Medical Technologies are locatedand Medical Technologies are locatedand Medical Technologies are located
Group Group Group Group HQHQHQHQ
� SIFISIFISIFISIFI holdsholdsholdsholds aaaa marketmarketmarketmarketmarketmarketmarketmarket shareshareshareshareshareshareshareshare ofofofofofofofof cacacacacacacaca........ 88888888%%%%%%%% ofofofof thethethethe ItalianItalianItalianItalianItalianItalianItalianItalian ophthalmicophthalmicophthalmicophthalmicophthalmicophthalmicophthalmicophthalmic marketmarketmarketmarketmarketmarketmarketmarket,,,, inininin 3333rdrdrdrd
positionpositionpositionposition afterafterafterafter AlconAlconAlconAlcon andandandand AllerganAllerganAllerganAllergan
Leader in Italy, Leader in Italy, Leader in Italy, Leader in Italy, Leader in Italy, Leader in Italy, Leader in Italy, Leader in Italy, expandingexpandingexpandingexpandingexpandingexpandingexpandingexpanding abroadabroadabroadabroadabroadabroadabroadabroad
� SIFISIFISIFISIFI PharmaPharmaPharmaPharma currentlycurrentlycurrentlycurrently distributesdistributesdistributesdistributes itsitsitsits pharmaceuticalspharmaceuticalspharmaceuticalspharmaceuticals inininin internationalinternationalinternationalinternational marketsmarketsmarketsmarkets andandandand
hashashashas aaaaaaaa directdirectdirectdirectdirectdirectdirectdirect salessalessalessalessalessalessalessales presencepresencepresencepresencepresencepresencepresencepresence inininininininin MexicoMexicoMexicoMexicoMexicoMexicoMexicoMexico andandandandandandandand RomaniaRomaniaRomaniaRomaniaRomaniaRomaniaRomaniaRomania::::::::
� RoughlyRoughlyRoughlyRoughly 85858585%%%% ofofofof SIFISIFISIFISIFI Pharma’sPharma’sPharma’sPharma’s revenuesrevenuesrevenuesrevenues areareareare concentratedconcentratedconcentratedconcentrated inininin thethethethe TopTopTopTopTopTopTopTop 55555555 EUEUEUEUEUEUEUEU regionregionregionregionregionregionregionregion,,,,ItalyItalyItalyItaly takingtakingtakingtaking thethethethe largestlargestlargestlargest shareshareshareshare;;;;
� TheTheTheThe remainderremainderremainderremainder originatesoriginatesoriginatesoriginates fromfromfromfrom emergingemergingemergingemergingemergingemergingemergingemerging marketsmarketsmarketsmarketsmarketsmarketsmarketsmarkets (Mexico,(Mexico,(Mexico,(Mexico,(Mexico,(Mexico,(Mexico,(Mexico, RussiaRussiaRussiaRussiaRussiaRussiaRussiaRussia andandandandandandandand Turkey)Turkey)Turkey)Turkey)Turkey)Turkey)Turkey)Turkey) andandandandEastEastEastEast EuropeEuropeEuropeEurope (Romania)(Romania)(Romania)(Romania);;;;
GoingGoingGoingGoing forward,forward,forward,forward, growthgrowthgrowthgrowth willwillwillwill bebebebe ledledledled bybybyby aaaa markedmarkedmarkedmarked internationalinternationalinternationalinternationalinternationalinternationalinternationalinternational expansionexpansionexpansionexpansionexpansionexpansionexpansionexpansion inininin� GoingGoingGoingGoing forward,forward,forward,forward, growthgrowthgrowthgrowth willwillwillwill bebebebe ledledledled bybybyby aaaa markedmarkedmarkedmarked internationalinternationalinternationalinternationalinternationalinternationalinternationalinternational expansionexpansionexpansionexpansionexpansionexpansionexpansionexpansion inininin
selectedselectedselectedselected marketsmarketsmarketsmarkets whilewhilewhilewhile consolidatingconsolidatingconsolidatingconsolidating thethethethe domesticdomesticdomesticdomesticdomesticdomesticdomesticdomestic leadershipleadershipleadershipleadershipleadershipleadershipleadershipleadership positionpositionpositionposition
MultiMultiMultiMulti----channel strategy for optimum product portfolio managementchannel strategy for optimum product portfolio managementchannel strategy for optimum product portfolio managementchannel strategy for optimum product portfolio management
� SIFI Sales Force details Cluster 1Cluster 1 products to Ophthalmologists
� Eyelab Reps detail Cluster 2 Cluster 2 products to Ophthalmologists (+ paediatricians and GPs)
DomesticDomesticDomesticDomesticDomesticDomesticDomesticDomestic salessalessalessalessalessalessalessales coveragecoveragecoveragecoveragecoveragecoveragecoveragecoverage
� Eyelab Reps detail Cluster 2 Cluster 2 products to Ophthalmologists (+ paediatricians and GPs)
Rx, OTC, Medical Devices, Rx, OTC, Medical Devices, Rx, OTC, Medical Devices, Rx, OTC, Medical Devices, Rx, OTC, Medical Devices, Rx, OTC, Medical Devices, Rx, OTC, Medical Devices, Rx, OTC, Medical Devices, NutraceuticalsNutraceuticalsNutraceuticalsNutraceuticalsNutraceuticalsNutraceuticalsNutraceuticalsNutraceuticals
Detailing to 7,500Detailing to 7,500Detailing to 7,500Detailing to 7,500OphtalmologistsOphtalmologistsOphtalmologistsOphtalmologists
SIFI SIFI SIFI SIFI SIFI SIFI SIFI SIFI EyelabEyelabEyelabEyelabEyelabEyelabEyelabEyelab
Direct sale toDirect sale toDirect sale toDirect sale toselected pharmaciesselected pharmaciesselected pharmaciesselected pharmacies
SIFI SIFI SIFI SIFI SIFI SIFI SIFI SIFI Sales forceSales forceSales forceSales force
36 reps + 6 AMs36 reps + 6 AMs36 reps + 6 AMs36 reps + 6 AMs
EyelabEyelabEyelabEyelabEyelabEyelabEyelabEyelabSales forceSales forceSales forceSales force
20 reps + 3 AMs20 reps + 3 AMs20 reps + 3 AMs20 reps + 3 AMs
through Pharmacy specialist through Pharmacy specialist through Pharmacy specialist through Pharmacy specialist through Pharmacy specialist through Pharmacy specialist through Pharmacy specialist through Pharmacy specialist
partner (by 2015)partner (by 2015)partner (by 2015)partner (by 2015)
Global Global Global Global Global Global Global Global growthgrowthgrowthgrowthgrowthgrowthgrowthgrowth strategystrategystrategystrategystrategystrategystrategystrategy
International International International International International International International International marketsmarketsmarketsmarketsmarketsmarketsmarketsmarkets
EmergingEmergingEmergingEmergingEmergingEmergingEmergingEmerging marketsmarketsmarketsmarketsmarketsmarketsmarketsmarkets
Romania, Mexico, Romania, Mexico, Romania, Mexico, Romania, Mexico, Russia, Russia, Russia, Russia, TurkeyTurkeyTurkeyTurkey, China , China , China , China
DirectDirect subsidiarysubsidiary onlyonly forforRomania and Mexico; Romania and Mexico; locallocalpartner/partner/distributordistributor forfor otherother
Mature Mature Mature Mature Mature Mature Mature Mature marketsmarketsmarketsmarketsmarketsmarketsmarketsmarkets
SpainSpainSpainSpain, UK , UK , UK , UK ((locallocal distributordistributor/partner)/partner)
OtherOtherOtherOther EU EU EU EU marketsmarketsmarketsmarkets((distributorsdistributors currentlycurrently in in
Global Global Global Global Global Global Global Global agreementsagreementsagreementsagreementsagreementsagreementsagreementsagreements
OutOutOutOut----licensing licensing licensing licensing
CollaborationCollaboration agreementsagreementswithwith global global partnerspartners on on addedadded valuevalue proprietaryproprietaryassetsassets (i.e. antinfective-
Romania and Mexico; Romania and Mexico; locallocalpartner/partner/distributordistributor forfor otherother
countriescountries
((distributorsdistributors currentlycurrently in in evaluationevaluation)) assetsassets (i.e. antinfective-
antinflammatorycombination)
InInInInInInInIn--------LicensingLicensingLicensingLicensingLicensingLicensingLicensingLicensing
Leveraging SIFI’s core strengths to attract opportunities:Leveraging SIFI’s core strengths to attract opportunities:Leveraging SIFI’s core strengths to attract opportunities:Leveraging SIFI’s core strengths to attract opportunities:
� a track record of collaborative relationshipsa track record of collaborative relationshipsa track record of collaborative relationshipsa track record of collaborative relationships
PartnershipsPartnershipsPartnershipsPartnershipsPartnershipsPartnershipsPartnershipsPartnerships
China China China China
Romania, Romania, Romania, Romania, MexicoMexicoMexicoMexico
� a track record of collaborative relationshipsa track record of collaborative relationshipsa track record of collaborative relationshipsa track record of collaborative relationships
� ppppositionedositionedositionedositioned as midas midas midas mid----sized, specialist partner with core R&D and sized, specialist partner with core R&D and sized, specialist partner with core R&D and sized, specialist partner with core R&D and
M&S competencesM&S competencesM&S competencesM&S competences
SpainSpainSpainSpain(Angelini)(Angelini)(Angelini)(Angelini)
UK (UK (UK (UK (MoorfieldsMoorfieldsMoorfieldsMoorfields))))
China China China China (COP) (COP) (COP) (COP)
TurkeyTurkeyTurkeyTurkey((((TekaTekaTekaTeka)))) China Otsuka Pharmaceutical Co., LtdChina Otsuka Pharmaceutical Co., Ltd
R&DR&DR&DR&DR&DR&DR&DR&D -------- activitiesactivitiesactivitiesactivitiesactivitiesactivitiesactivitiesactivities
•LineLineLineLine extensionsextensionsextensionsextensions
•New New New New drugdrugdrugdrug delivery delivery delivery delivery systemssystemssystemssystems
• OphthaOphthaOphthaOphtha ––––formulationsformulationsformulationsformulations
•ProprietaryProprietaryProprietaryProprietary dossiersdossiersdossiersdossiers’ ’ ’ ’ update/upgrade update/upgrade update/upgrade update/upgrade totototocontinuouslycontinuouslycontinuouslycontinuously meetmeetmeetmeet GMP GMP GMP GMP standardsstandardsstandardsstandards
•RetinalRetinalRetinalRetinal degenerationdegenerationdegenerationdegeneration & & & & GlaucomaGlaucomaGlaucomaGlaucoma
•InfectionInfectionInfectionInfection
• OphthaOphthaOphthaOphtha ––––formulationsformulationsformulationsformulationsdevelopmentdevelopmentdevelopmentdevelopment
standardsstandardsstandardsstandards
RegulatoryRegulatoryRegulatoryRegulatoryRegulatoryRegulatoryRegulatoryRegulatorycompliancecompliancecompliancecompliancecompliancecompliancecompliancecompliance
IncrementalIncrementalIncrementalIncrementalIncrementalIncrementalIncrementalIncrementalinnovationinnovationinnovationinnovationinnovationinnovationinnovationinnovation
Back Back Back Back Back Back Back Back ofofofofofofofofthe the the the the the the the EyeEyeEyeEyeEyeEyeEyeEye
AnteriorAnteriorAnteriorAnteriorAnteriorAnteriorAnteriorAnterior
SegmentofSegmentofSegmentofSegmentofSegmentofSegmentofSegmentofSegmentof
the the the the the the the the EyeEyeEyeEyeEyeEyeEyeEye GlaucomaGlaucomaGlaucomaGlaucoma
•Public Public Public Public fundedfundedfundedfunded projectsprojectsprojectsprojects(Italy/EU)(Italy/EU)(Italy/EU)(Italy/EU)
•R&DR&DR&DR&D partnershipspartnershipspartnershipspartnerships
•InflammationInflammationInflammationInflammation
•Dry Dry Dry Dry EyeEyeEyeEye////OcularOcularOcularOcular surfacesurfacesurfacesurface
•WoundWoundWoundWound healinghealinghealinghealing
the the the the the the the the EyeEyeEyeEyeEyeEyeEyeEye
R&DR&DR&DR&DR&DR&DR&DR&D -------- open open open open open open open open innovationinnovationinnovationinnovationinnovationinnovationinnovationinnovation
�� WideWideWideWideWideWideWideWide IPIPIPIPIPIPIPIP acrossacrossacrossacrossacrossacrossacrossacross allallallallallallallall businessbusinessbusinessbusinessbusinessbusinessbusinessbusiness segmentssegmentssegmentssegmentssegmentssegmentssegmentssegments
StrongStrongStrongStrong teamsteamsteamsteams ofofofof SIFISIFISIFISIFI researchersresearchersresearchersresearchers generatedgeneratedgeneratedgenerated inininin thethethethe lastlastlastlast 3333 yearsyearsyearsyears 6060606060606060 patentspatentspatentspatents andandandand patentpatentpatentpatent applicationsapplicationsapplicationsapplications::::
2020202020202020 inininin PharmaPharmaPharmaPharma eeee 4040404040404040 inininin MedtechMedtechMedtechMedtech2020202020202020 inininin PharmaPharmaPharmaPharma eeee 4040404040404040 inininin MedtechMedtechMedtechMedtech
�� OpenOpenOpenOpenOpenOpenOpenOpen InnovationInnovationInnovationInnovationInnovationInnovationInnovationInnovation
CurrentlyCurrentlyCurrentlyCurrently 2222 majormajormajormajor collaborativecollaborativecollaborativecollaborative R&DR&DR&DR&D projectsprojectsprojectsprojects::::
ODAKODAKODAKODAKODAKODAKODAKODAK:::: preclinicalpreclinicalpreclinicalpreclinical andandandand clinicalclinicalclinicalclinical researchresearchresearchresearch ofofofof thethethethe OrphanOrphanOrphanOrphan DrugDrugDrugDrug PolihexanidePolihexanidePolihexanidePolihexanide (PHMB)(PHMB)(PHMB)(PHMB) totototo treattreattreattreat
AcanthamoebaAcanthamoebaAcanthamoebaAcanthamoeba keratitiskeratitiskeratitiskeratitis (AK)(AK)(AK)(AK).... FundedFundedFundedFunded underunderunderunder aaaa EuropeanEuropeanEuropeanEuropean (FP(FP(FP(FP7777)))) Grant,Grant,Grant,Grant, itititit involvesinvolvesinvolvesinvolves anananan internationalinternationalinternationalinternational
consortiumconsortiumconsortiumconsortium ofofofof partners,partners,partners,partners, includingincludingincludingincluding thethethethe MoorfieldsMoorfieldsMoorfieldsMoorfields PharmaceuticalPharmaceuticalPharmaceuticalPharmaceutical (UK)(UK)(UK)(UK) andandandand thethethethe UniversityUniversityUniversityUniversity ofofofof
RouenRouenRouenRouen (FR),(FR),(FR),(FR), forforforfor aaaa totaltotaltotaltotal budgetbudgetbudgetbudget ofofofof €€€€ 5555....5555mmmm
HippocratesHippocratesHippocratesHippocratesHippocratesHippocratesHippocratesHippocrates:::: developmentdevelopmentdevelopmentdevelopment ofofofof biosensorsbiosensorsbiosensorsbiosensors,,,, drugdrugdrugdrug deliverydeliverydeliverydelivery carrierscarrierscarrierscarriers andandandand medicalmedicalmedicalmedical ICTICTICTICT solutionssolutionssolutionssolutions,,,, basedbasedbasedbased
onononon micromicromicromicro andandandand nanonanonanonano technologiestechnologiestechnologiestechnologies.... FundedFundedFundedFunded underunderunderunder aaaa nationalnationalnationalnational grantgrantgrantgrant (MIUR),(MIUR),(MIUR),(MIUR), itititit involvesinvolvesinvolvesinvolves aaaa SicilianSicilianSicilianSicilian
TechnologicalTechnologicalTechnologicalTechnological ClusterClusterClusterCluster (Distretto(Distretto(Distretto(Distretto TecnologicoTecnologicoTecnologicoTecnologico SiciliaSiciliaSiciliaSicilia MicroMicroMicroMicro eeee NanoNanoNanoNano Sistemi),Sistemi),Sistemi),Sistemi), includingincludingincludingincluding partnerspartnerspartnerspartners suchsuchsuchsuch
asasasas STMicroelectronicsSTMicroelectronicsSTMicroelectronicsSTMicroelectronics,,,, ItaltelItaltelItaltelItaltel andandandand ISMETT,ISMETT,ISMETT,ISMETT, forforforfor aaaa totaltotaltotaltotal budgetbudgetbudgetbudget ofofofof €€€€ 22222222mmmm
R&DR&DR&DR&DR&DR&DR&DR&D
The ODAK The ODAK The ODAK The ODAK europeaneuropeaneuropeaneuropean consortiumconsortiumconsortiumconsortium
For more info visit www.odak-project.eu
R&DR&DR&DR&DR&DR&DR&DR&D
For more info visitwww.hippocrates-project.org/EN/
PipelinePipelinePipelinePipelinePipelinePipelinePipelinePipeline
Project Project Project Project
CodeCodeCodeCode
TherapeuticTherapeuticTherapeuticTherapeutic indicationindicationindicationindication / / / / intendedintendedintendedintended useuseuseuse RegulatoryRegulatoryRegulatoryRegulatory Status Status Status Status Development stageDevelopment stageDevelopment stageDevelopment stage ExpectedExpectedExpectedExpected
launchlaunchlaunchlaunch
XNTXNTXNTXNTXNTXNTXNTXNT MildMildMildMild totototo moderate Dry moderate Dry moderate Dry moderate Dry EyeEyeEyeEye, , , , associatedassociatedassociatedassociated withwithwithwith ocularocularocularocular
surfacesurfacesurfacesurface oxidativeoxidativeoxidativeoxidative stressstressstressstress....
MedicalMedicalMedicalMedical DeviceDeviceDeviceDevice LaunchLaunchLaunchLaunch Q2Q2Q2Q2----2014201420142014
MDGMDGMDGMDGMDGMDGMDGMDG Sterile Sterile Sterile Sterile medicalmedicalmedicalmedical devicedevicedevicedevice gauzesgauzesgauzesgauzes withwithwithwith 3 3 3 3 differentdifferentdifferentdifferent
presentationspresentationspresentationspresentations aimedaimedaimedaimed at at at at cleansingcleansingcleansingcleansing, , , , moisturizingmoisturizingmoisturizingmoisturizing and and and and
sanitizingsanitizingsanitizingsanitizing the the the the periocularperiocularperiocularperiocular areaareaareaarea
MedicalMedicalMedicalMedical DeviceDeviceDeviceDevice IndustrialisationIndustrialisationIndustrialisationIndustrialisation Q4Q4Q4Q4----2014201420142014
AVSAVSAVSAVSAVSAVSAVSAVS NutraceuticalNutraceuticalNutraceuticalNutraceutical addressedaddressedaddressedaddressed totototo supportsupportsupportsupport patientspatientspatientspatients withwithwithwith retinalretinalretinalretinal
degenerationdegenerationdegenerationdegeneration pathologiespathologiespathologiespathologies....
NutraceuticalNutraceuticalNutraceuticalNutraceutical IndustrialisationIndustrialisationIndustrialisationIndustrialisation Q3Q3Q3Q3----2014201420142014
MyCMyCMyCMyCMyCMyCMyCMyC NutraceuticalNutraceuticalNutraceuticalNutraceutical addressedaddressedaddressedaddressed totototo supportsupportsupportsupport patientspatientspatientspatients withwithwithwith
MyopiaMyopiaMyopiaMyopia at at at at differentdifferentdifferentdifferent stage stage stage stage ofofofof progressionprogressionprogressionprogression....
NutraceuticalNutraceuticalNutraceuticalNutraceutical IndustrialisationIndustrialisationIndustrialisationIndustrialisation Q1Q1Q1Q1----2015201520152015
DRLsDRLsDRLsDRLsDRLsDRLsDRLsDRLs NutraceuticalNutraceuticalNutraceuticalNutraceutical addressedaddressedaddressedaddressed totototo supportsupportsupportsupport patientspatientspatientspatients withwithwithwith
DiabeticDiabeticDiabeticDiabetic RetinopathyRetinopathyRetinopathyRetinopathy at at at at specificspecificspecificspecific stage stage stage stage ofofofof progressionprogressionprogressionprogression....
NutraceuticalNutraceuticalNutraceuticalNutraceutical FormulationFormulationFormulationFormulation
developmentdevelopmentdevelopmentdevelopment
Q4Q4Q4Q4----2015201520152015
ATSATSATSATSATSATSATSATS ModerateModerateModerateModerate totototo severe Dry severe Dry severe Dry severe Dry EyeEyeEyeEye
ControlControlControlControl ofofofof inflammationinflammationinflammationinflammation atatatat ocularocularocularocular surfacesurfacesurfacesurface levellevellevellevel....
MedicalMedicalMedicalMedical DeviceDeviceDeviceDevice
(‘(‘(‘(‘subamedsubamedsubamedsubamed’)’)’)’)
IndustrialisationIndustrialisationIndustrialisationIndustrialisation----DossierDossierDossierDossier
preparationpreparationpreparationpreparation
Q1Q1Q1Q1----2016201620162016
ControlControlControlControl ofofofof inflammationinflammationinflammationinflammation atatatat ocularocularocularocular surfacesurfacesurfacesurface levellevellevellevel.... (‘(‘(‘(‘subamedsubamedsubamedsubamed’)’)’)’) preparationpreparationpreparationpreparation
LtPFLtPFLtPFLtPFLtPFLtPFLtPFLtPF IOPIOPIOPIOP loweringloweringloweringlowering agentagentagentagent
Innovative PF Innovative PF Innovative PF Innovative PF formulationformulationformulationformulation
AddedAddedAddedAdded valurevalurevalurevalure genericgenericgenericgeneric IndustrialisationIndustrialisationIndustrialisationIndustrialisation Q2Q2Q2Q2----2016201620162016
ODAKODAKODAKODAKODAKODAKODAKODAK TreatmentTreatmentTreatmentTreatment ofofofof rare rare rare rare cornealcornealcornealcorneal infectioninfectioninfectioninfection AcanthamoebaAcanthamoebaAcanthamoebaAcanthamoeba
keratitiskeratitiskeratitiskeratitis
Orphan DrugOrphan DrugOrphan DrugOrphan Drug PreclinicalPreclinicalPreclinicalPreclinical 2018201820182018
PipelinePipelinePipelinePipelinePipelinePipelinePipelinePipeline
XNTXNTXNTXNTXNTXNTXNTXNT
2014201420142014 2015201520152015 2016201620162016 2017201720172017 2018201820182018
H1 H2 H1 H2 H1 H2 H1 H2 H1 H2
XNTXNTXNTXNTXNTXNTXNTXNT
MDGMDGMDGMDGMDGMDGMDGMDG
AVSAVSAVSAVSAVSAVSAVSAVS
MyCMyCMyCMyCMyCMyCMyCMyC
DRLsDRLsDRLsDRLsDRLsDRLsDRLsDRLs
ATSATSATSATSATSATSATSATS
LtPFLtPFLtPFLtPFLtPFLtPFLtPFLtPF
ODAKODAKODAKODAKODAKODAKODAKODAK
Key financialsKey financialsKey financialsKey financialsKey financialsKey financialsKey financialsKey financials
50,0
60,0
70,0
Sales (m Sales (m Sales (m Sales (m Sales (m Sales (m Sales (m Sales (m €€€€€€€€))))))))
-
10,0
20,0
30,0
40,0
50,0
2010 2011 2012 2013
12,0
14,0
EBITDA (m EBITDA (m EBITDA (m EBITDA (m EBITDA (m EBITDA (m EBITDA (m EBITDA (m €€€€€€€€))))))))
21%
20%
25%
EBITDA (% on net revenues)EBITDA (% on net revenues)EBITDA (% on net revenues)EBITDA (% on net revenues)EBITDA (% on net revenues)EBITDA (% on net revenues)EBITDA (% on net revenues)EBITDA (% on net revenues)
-
2,0
4,0
6,0
8,0
10,0
12,0
2010 2011 2012 2013
8%
15%16%
0%
5%
10%
15%
20%
2010 2011 2012 2013
� AAAA 76767676----yearyearyearyear longlonglonglong devotiondevotiondevotiondevotion totototo OphthalmologyOphthalmologyOphthalmologyOphthalmology
Closing remarksClosing remarksClosing remarksClosing remarksClosing remarksClosing remarksClosing remarksClosing remarks
� SolidSolidSolidSolid reputationreputationreputationreputation withinwithinwithinwithin thethethethe pharmaceutical/ophthalmicpharmaceutical/ophthalmicpharmaceutical/ophthalmicpharmaceutical/ophthalmic communitycommunitycommunitycommunity
� ExperiencedExperiencedExperiencedExperienced managementmanagementmanagementmanagement teamteamteamteam
� AAAA marketmarketmarketmarket leaderleaderleaderleader inininin ItalyItalyItalyItaly
- high-quality and comprehensive product list- specialised, long-established, full-time sales forces
CommitmentCommitmentCommitmentCommitment totototo buildingbuildingbuildingbuilding longlonglonglong----lastinglastinglastinglasting commercialcommercialcommercialcommercial andandandand developmentdevelopmentdevelopmentdevelopment alliancesalliancesalliancesalliances� CommitmentCommitmentCommitmentCommitment totototo buildingbuildingbuildingbuilding longlonglonglong----lastinglastinglastinglasting commercialcommercialcommercialcommercial andandandand developmentdevelopmentdevelopmentdevelopment alliancesalliancesalliancesalliances
� AAAA growinggrowinggrowinggrowing internationalinternationalinternationalinternational networknetworknetworknetwork (Companies(Companies(Companies(Companies andandandand ResearchResearchResearchResearch Institutions)Institutions)Institutions)Institutions)
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ForForForFor furtherfurtherfurtherfurther information information information information pleasepleasepleaseplease contactcontactcontactcontact::::
Marcello PizzulloMarcello PizzulloMarcello PizzulloMarcello PizzulloMarcello PizzulloMarcello PizzulloMarcello PizzulloMarcello Pizzullo
Head of Business and Portfolio DevelopmentHead of Business and Portfolio Development
SIFI S.p.ASIFI S.p.ASIFI S.p.ASIFI S.p.A
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