side event 2695: lmos, synbio and dsi experiences from ...€¦ · un biodiversity conference 2018,...
TRANSCRIPT
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UN Biodiversity Conference 2018, Sharm El Sheikh, Egypt22 November 2018
Side event 2695: LMOs, SynBio and DSI –
experiences from farmers and young scientists
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• 13.15: Opening and Introduction
Joseph Opoku Gakpo, Journalist, Ghana, Alliance for Science
• 13.25: Farmer experiences with first generation of GM crops
• 13.35: Experiences of young scientists with synthetic biology
• 13.45: Experiences of young scientists with DSI
• 14.00: Q&A – Discussion
Agenda
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• Edwin Paraluman, farmer from the Philippines
Farmer experiences
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• Geoffrey Otim, Africa Synbio
• iGEM Delegation
Experiences of young scientists with SynBio
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Synthetic Biology in Africa
Geoffrey Otim, MSc
SynBio Africa
•5
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• First Synbio community in Africa
• Legally registered in Uganda
• Platform for scientists, researchers, policy makers, students and the public
• Goal: discuss and engage in SynBio
• over 60 members from Uganda, Kenya, Ghana, and Somalia
• To become a member: [email protected]
•11/22/2018
SYNBIO Africa
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Synthetic biology uses engineering principles to:
Design or redesign and construct biological parts,
devices and systems for useful purposes.
No internationally agreed definition on SynBio
Definition
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Synthetic biology promises to provide sustainable, low-cost technologies to many grand challenges of the modern society via innovations in agriculture, health care, energy production and environmental conservation.
https://synbioafrica.com/
Why Synthetic Biology?
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Recombinant DNA technology: allows to cut and paste pieces of DNA atdesired locations cleaved by restriction enzymes
Bacterium
Chromosome Plasmids
Extraneous DNA
Chromosome
recom
bin
ant D
NA
Fluorescent Proteins: allow through fluorescence microscopy to measure the concentration of a protein and thus the level of expression of the corresponding gene
gene gfp
•9
Underlying Technologies
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• DNA Sequencing • DNA Synthesis• Gene editing (e.g. CRISPR-Cas9)
•10
Underlying Technologies
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• Sensing of pathogens, cancer, toxins• Targeted drug delivery• Diagnostics
•11
Applications:Health Care
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• Reduction use of fertilizers and pesticides
• Industrial uses of biomass, shift to feedstock production
• Improvement of the nutritional value of foods (e.g. oilseed crops with boosted levels of omega 3 fatty acids)
• Reduction of land usage
•12
Applications:Agriculture
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•13
For example, bacteria that…- Produce bio-fuels- Transform waste into energy
Applications:Renewable/Alternative Energy
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•11/22/2018
Applications:bioremediation and pollution control
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• Ana Sifuentes, iGEM Foundation, Mexico
• Nina Jerala, Slovenia
• Janina Lüders, Germany
• Aiswarya Prasad, India
• Justin Vigar, Canada
•15
iGEM Delegation
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+ 42
Countries
+ 30,000
Participants
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Production of biofuel from waste
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Easy to handle, smart-
phone readable, paper
based and cell-free test-
strip to detect water
pollutants
Proof of principle tackling:
- Drug contamination in
drinks
- Heavy metal pollution in
water
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Cat pheromone based bio-synthetic deterrent
to reduce grain loss due to rodent attacks
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The Alberta Oil Sands have
generated over 1.18 trillion
litres of contaminated
wastewater, stored in
tailings ponds.
Proof of principle tackling:
- Engineering microbes able
to degrade toxic organic
compounds and sequester
toxic heavy metals
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• Fabian Rohden, German Association for SynBio, Germany
• Noemi Santamaria, University of Basel, Switzerland
Experiences of young scientists with DSI
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Digital Sequence Information and
Access & Benefit Sharing
Fabian Rohden
[email protected] Association for Synthetic Biology@gasb_synbio
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Access and Benefit Sharing
Country ofOrigin
PIC/MATCommercial
Product
Benefit Sharing
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DSI - Questions about the term
• “Digital” - What about non-digital information?
• “Sequence“ - What is a sequence?
• “Information“ - data + X
--> The term is far away from being well-defined!
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DSI in research
DSIABS
Conservation
ResearchPublic Health
F & A
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The nature of nature
Metabolites
DNA [4 Bases]
RNA [4 Bases]
Proteins [20 AA]
DSI
Products
--> The focus should be on the commercial products
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Experiences with DSI – Zika Outbreak
• Guillain–Barré syndrome
• Congenital Microcephaly
congenital Zika virus syndrome
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Speakers:
• Edwin Paraluman, farmer, Philippines
• Geoffrey Otim, SynBio Africa, Uganda
• Ana Sifuentes, iGEM Foundation, Mexico
• Nina Jerala, iGem, Slovenia
• Janina Lüders, iGem, Germany
• Aiswarya Prasad, iGem, India
• Justin Vigar, iGem, Canada
• Fabian Rohden, German Association for SynBio, Germany
• Noemi Santamaria, University of Basel, Switzerland
Feel free to contact
Q&A – Discussion