ART I C L E S

Senescent cells harbour features of the cancerepigenomeHazel A. Cruickshanks1,5,6, Tony McBryan1,6, David M. Nelson1, Nathan D. VanderKraats2, Parisha P. Shah3,John van Tuyn1, Taranjit Singh Rai1,5, Claire Brock1, Greg Donahue3, Donncha S. Dunican4, Mark E. Drotar1,Richard R. Meehan4, John R. Edwards2, Shelley L. Berger3 and Peter D. Adams1,7

Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicativesenescence is a tumour suppressor process that imposes a limit on the proliferative potential of normal cells that all cancer cellsmust bypass. Here we show by whole-genome single-nucleotide bisulfite sequencing that replicative senescent human cellsexhibit widespread DNA hypomethylation and focal hypermethylation. Hypomethylation occurs preferentially at gene-poor,late-replicating, lamin-associated domains and is linked to mislocalization of the maintenance DNA methyltransferase (DNMT1) incells approaching senescence. Low-level gains of methylation are enriched in CpG islands, including at genes whose methylationand silencing is thought to promote cancer. Gains and losses of methylation in replicative senescence are thus qualitatively similarto those in cancer, and this ‘reprogrammed’ methylation landscape is largely retained when cells bypass senescence.Consequently, the DNA methylome of senescent cells might promote malignancy, if these cells escape the proliferative barrier.

The DNA methylomes of cancer cells exhibit many aberrationswhen compared with normal cells. This includes DNA hypo- andhypermethylation and associated transcriptional de-repression, genesilencing and genome instability. Global DNA hypomethylation isthought to cause expression and recombination of repetitive sequencesleading to instability of the cancer genome, whereas hypermethylationat CpG islands can contribute to cell transformation by silencingtumour suppressor genes1,2. More recent studies have also linkedDNA hypomethylation in cancer cells to formation of repressivechromatin domains and gene silencing3. The origin of these aberrationsis unknown, but may be linked to perturbations in the DNAmodification machinery.Cellular senescence is a stable proliferation arrest and an

important tumour suppressor mechanism4–7. For example, replicativesenescence blocks tumour formation by imposing an upper limiton the proliferative capacity of normal cells8,9. To become fullytransformed, cancer cells must bypass senescence (by circumventingor inactivating the senescence barrier before or after its imposition,respectively). Chromatin changes are apparent in senescent cells,but they are only beginning to be characterized at the whole

1Institute of Cancer Sciences, University of Glasgow and Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK. 2Center for Pharmacogenomics, WashingtonUniversity School of Medicine, St Louis, Missouri 63110, USA. 3Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.4MRC Human Genetics Unit at the Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK. 5Presentaddresses: MRC Human Genetics Unit at the Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK;(H.A.C.); Institute of Biomedical and Environmental Health Research, University of the West of Scotland, Paisley, PA1 2BE, UK (T.S.R.). 6These authors contributedequally to this work.7Correspondence should be addressed to P.D.A. (e-mail: p.adams@beatson.gla.ac.uk)

Received 20 September 2012; accepted 14 October 2013; published online 24 November 2013; DOI: 10.1038/ncb2879

genome level10–18. There is no comprehensive analysis of DNAmethylation in senescent cells. Therefore, we set out to comprehensivelymap and compare the DNA methylome of proliferating andreplicatively senescent cells.

RESULTSGlobal hypomethylation and focal hypermethylation insenescenceIMR90 cells undergo replicative senescence after prolonged passagein culture through a combination of shortened telomeres andinduction of p16INK4a (p16; ref. 19). Senescent IMR90 cellsexhibited characteristic features of senescence, including proliferationarrest, enlarged morphology, expression of senescence-associatedβ-galactosidase (SA β-gal) activity and p16, repression of cyclin A, andchromatin changes marked by senescence-associated heterochromatinfoci (SAHFs) and recruitment of the histone chaperone, HIRA,to PML (promyelocytic leukemia) nuclear bodies (SupplementaryFigs 1a–i)4,12,19. Moreover, gene expression profiling of these cellsshowed altered expression of many genes18, including repressionof proliferation-promoting genes (Supplementary Figs 2a–c), and

NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013 1495

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

1,500

1,000

500

Chr 4

100

1000

1000

200 50 Mb

–200

0

0

Senescent percentage methylation

Overlay

Difference p

Proliferating percentage methylation

Unmethylated CpGMethylated CpG

65 58 4235

0

Prolif.

Prolif. Sen.

Sen.

Hypo

Hyper

Pro

lif.

Ave

rage

inte

nsity

uni

ts

Sen

.ssDNA 5-MeC

Hypo

Hyper

Hypo

HyperA

vera

ge

size

of

DM

R (b

p)

No

. of

DM

Rs

Per

cent

age

met

hyla

tion

(sen

esce

nt)

–per

cent

age

met

hyla

tion

(pro

lifer

atin

g)

4060

No

. of

Cp

G (

×104

)

80100120140

200

0 20 40 80 10060

5

0

–15

–10

–5

20,000

25,00030,000

5,000

0

10,000

15,000

60,000

75,000

0

15,000

30,000

45,000

a b dc

f

Per

cent

age

met

hyla

tion

(sen

esce

nt)

Percentage methylation (proliferating)

Percentage methylation (proliferating)

20

40

60

80

100

00 20 40 60 80 100

e

Diff

eren

ce p

200

0

–200

i jhg

Figure 1 Senescent cells exhibit overall hypomethylation and focalhypermethylation. (a) Proliferating (Prolif.) and senescent (Sen.) IMR90cells stained for 5-methylcytosine (5-MeC) and single-stranded DNA (ssDNA).Scale bar, 5 µm. (b) Quantitation of a in three independent experiments(100 cells each); error bars, mean ± s.e.m. (c) Percentages of methylatedand unmethylated basecalls at reference CpG dinucleotides in proliferatingand senescent cells. (d) Numbers of CpG dinucleotides becominghypomethylated (hypo) and hypermethylated (hyper) in senescence. (e)Plot of chromosome 4 (chr 4) percentage methylation for proliferating andsenescent cells. An overlay of these two plots is shown with difference p,proportional to the P value differences between methylation of proliferating

and senescent cells. Negative and positive values are hypomethylationand hypermethylation, respectively. (f) Enlargement of boxed region frome. (g,h) Across the whole genome, regions of intermediate methylation inproliferating cells tend to be hypomethylated in senescence. For g and hCpGs were split into 100 bins on the basis of proliferating methylation. Theaverage senescent methylation/methylation difference of each bin was thencomputed and plotted. (i) Number of hypomethylated and hypermethylatedDMRs (differentially methylated regions) over whole genome in senescentcells. (j) Average size of hypomethylated and hypermethylated DMRs overwhole genome. bp, base pairs. For c–j data are from whole-genome bisulfitesequencing of three independent replicates.

upregulation of many inflammatory mediators comprising anotherhallmark of senescence, the senescence-associated secretory phenotype(Supplementary Fig. 21d)20.

Initially, to compare DNAmethylation in proliferating and senescentcells, we stained cells with an antibody to 5′-methylcytosine. Consistentwith previous global analyses in cultured primary human cells14, thisshowed a decrease in overall DNA methylation in senescent cells

(Fig. 1a,b). Previous studies have indicated that the overall methylationlevel of immortal cells in culture is relatively stable14,21, suggestingthat the changes observed are not solely due to extended growth inculture, but are linked to a finite proliferative lifespan. To determineDNA methylation profiles across the whole genome, we carried outsingle-nucleotide bisulfite sequencing (in excess of 15× coveragein triplicate) of proliferating and senescent cells, yielding a total of

1496 NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

314.7Gbp) of sequence data (Supplementary Table 1). Analysis of thedata confirmed an overall decrease in cytosine methylation in senescentcells (Fig. 1c), from 65.0 to 58.4% methylcytosine basecalls, out of allbasecalls at reference CpG sites. Individual replicates of proliferatingand senescent cells were highly concordant (Supplementary Tables 2and 3 and Fig. 3a), with paired Pearson coefficients ranging from 0.88to 0.92 between like samples (Supplementary Table 4). Absolute levelsand changes in methylation at non-CpG sites, CHG and CHH (definedin SupplementaryMethods), were negligible (proliferating to senescent,0.44–0.41% (CHG) and 0.42–0.43% (CHH); Supplementary Tables 5and 6), compared with the frequency of failed bisulfite conversion ofunmethylated C to U (Supplementary Table 7). Net hypomethylationin senescence consisted of hypo- and hypermethylation events,although hypomethylation exceeded hypermethylation (Fig. 1d andSupplementary Table 8).As reported previously22, proliferating IMR90 cells contained

interspersed regions of near-complete and partial methylation. Whencompared with proliferating cells, senescent cells showed extendedregions of substantial hypomethylation, predominantly at regions ofpartial methylation in proliferating cells (Fig. 1e and SupplementaryFig. 3). In addition, senescent cells contained focal regions ofhypermethylation (Fig. 1d–f and Supplementary Fig. 3b). We useda sliding and expanding window approach to identify contiguoussignificant (false discovery rate, FDR< 0.05) differentially methylatedregions in senescence (sDMRs, defined in Supplementary Methods).There were more hypomethylated than hypermethylated sDMRs, andthe former were several fold longer and of greater magnitude than thelatter (Fig. 1g–j and Supplementary Fig. 3b).As senescence involves many programmed changes in gene

expression (Supplementary Fig. 2a–d; ref. 18), we asked whetheralterations in methylation correlate with these changes. Senescence-associated hypomethylation at genes generally occurred at thosegenes expressed at low levels in proliferating cells (SupplementaryFig. 4a–c) and, typically, was not associated with changes in geneexpression, regardless of whether it occurred at gene bodies orpromoters (Supplementary Fig. 4d,e). As gene promoters containingCpG islands are typically hypomethylated, as expected we observedlittle further hypomethylation at these sites (Supplementary Fig. 4c,f).When compared with hypomethylation, the magnitude of gene

promoter and body hypermethylation in senescent cells wastypically modest (Supplementary Fig. 4a,b,d,e). However, thiswas distributed more equally across low-, intermediate- andhigh-expression genes, with some bias towards low-expressiongenes (Supplementary Fig. 4a–c). Interestingly, compared withhypomethylation, hypermethylation was more likely to occur at geneswhose expression increased or decreased in senescence (SupplementaryFig. 4d–e). Indeed, amongst expressed genes in proliferating cells, therewas a significant (P = 0.0014) bias towards increased methylationof the promoter and downregulation in senescence (Fig. 2a andSupplementary Fig. 4g). The set of genes harbouring a CpG island,expressed in proliferating cells, and showing increased methylation insenescence includedmany cell cycle genes whose repression contributesto senescence-associated proliferation arrest, including histones(HIST1H2BM andHIST1H2AE),CCNA2,CENPA,MCM2 andTOP2A(Supplementary Table 9). Of the 221 genes in Supplementary Table 9,122 decreased and eight increased their expression in senescence. By

Ingenuity Pathway Analysis (IPA) the top ranked ‘biofunction’ of all221 genes in this dataset is ‘Cell Cycle’ (Supplementary Table 10).To extend this analysis, we adopted a more sophisticated approach

for discovering differential methylation patterns associated withchanges in gene expression. In this recently described approach23,differential methylation was represented as an interpolated curve, orsignature, and groups of genes with similarly shaped signatures andcorresponding expression changes were identified (Fig. 2b,c). Thisapproach identified a set of 139 genes (Supplementary Table 11). Ofthese, expression of 136 decreased in senescence, typically associatedwith increased DNA methylation at promoter proximal regions eitherside of the CpG island (Fig. 2d,e and Supplementary Fig. 5 and 11).IPA showed the top-ranked biofunction of this set to again be ‘CellCycle’ (Supplementary Table 12), and there was substantial and highlysignificant overlap of the genes in Supplementary Tables 9 and 11.Specifically, of 221 and 139 genes in Supplementary Tables 9 and 11respectively, 49 were in common (27.0-fold enrichment over random,P < 0.0001; Fig. 2f). In sum, two independent analyses showed thatincreased promoter methylation, particularly flanking CpG islands, isassociated with repression of cell cycle genes in senescence.

Hypomethylation occurs at late-replicating lamin-associateddomains (LADs)Next, we wanted to understand the process of hypomethylation insenescence. First, we set out to determine whether hypomethylationoccurs by a failure of maintenance methylation in proliferatingcells or active demethylation in senescent cells. We observedthat hypomethylation was already detectable in cyclin A-positiveproliferating cells as the population approached replicative senescence(near-senescent; Fig. 3a). Moreover, we failed to detect ongoing lossof methylation in senescent cells after proliferation arrest (Fig. 3b).Together, these results suggest that hypomethylation occurs in cellsapproaching senescence (near-senescent cells) before proliferationarrest, suggesting a failure of maintenance methylation by theDNA methyltransferase, DNMT1 (ref. 24). As shown previously25,expression ofDNMT1was repressed in senescent cells (Fig. 3c–e).Moresignificantly, in cells approaching senescence, we observed subnuclearrelocalization of DNMT1 (Fig. 3f,g). Specifically, in near-senescentcells there was a marked reduction in proliferating cyclin A-positivecells with nuclear DNMT1 puncta, compared with proliferatingcells (Fig. 3f,g). Previous studies have shown that S-phase DNMT1puncta are localized to late-replicating heterochromatic regions ofthe nucleus24. Indeed, we confirmed that some DNMT1 foci inproliferating cells co-localized with a constitutive heterochromaticsequence, such as pericentromeric satellite 2 (Fig. 3h). Unlike DNMT1,there was no change in the number of replication factories nor theirassembly at satellite 2 sequences, as judged by PCNA foci (Fig. 3i–j). Inline with altered DNMT1 localization, satellite 2 was hypomethylatedin senescent cells as shown previously26,27, and demonstrated bybisulfite sequencing and methylation-sensitive Southern blotting(Fig. 4a,b). Failure of these sequences to recruit DNMT1 wasalso accompanied by the de-compaction of their chromatin andupregulation of transcription, as shown here by fluorescence insitu hybridization (FISH) and reverse-transcription PCR (RT-PCR)respectively (see Fig. 4c–g) for a control genic sequence). Moreover,knockdown of DNMT1 triggered accelerated cellular senescence as

NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013 1497

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

0.4

0.3

0.2

0.1

0

–0.1

–0.2

–0.3

–0.4–6 –4 –2 0

Ln fold change expression Cluster 1

2 4 6

128 109

452 234

CD

CA

8

EN

PP

1

PO

LE2

FAM

64A

CA

12

CA

12

ITG

B3B

P

SH

MT1

RFC

5

NE

K2

RFC

2

NU

SA

P1

PO

LE2

KIF

20A

PFA

S

AE

BP

1

RFC

2

KIF

20A

NU

SA

P1

PFA

S

0.3

CpG density

Cp

G d

ensi

ty

Meth. diff.

0

–0.3

0.3

172 49 900

–0.3–5 kb +5 kbTSS

Met

hyla

tion

diff

eren

ce

c

d

e f

RFC2–2.6517

RFC2–2.6517

RFC2–2.6517

RFC2–2.6517

1.0

0.5

0

–0.5

–1.0

TSSTSSTSSTSS

DNA methylation replicates CpG density

Met

hyla

tion

diff

eren

ce

(Sen

.–P

rolif

.)

–5 kb 0 +5 kb –5 kb 0 +5 kb –5 kb 0 +5 kb –5 kb 0 +5 kb

a b

Figure 2 Promoter proximal methylation of transcriptionally repressedcell cycle genes. (a) Ln fold change of gene expression betweenproliferating and senescent cells (positive values, increased expressionin senescence; negative values, decreased expression in senescence)against the difference in promoter methylation between proliferating andsenescent cells (Sen. − Prolif.). Analysis only for genes expressed abovethe median level of expression in proliferating cells. The red numbersshow the number of genes (expressed in proliferating cells) with indicateddirections of expression (FDR<0.05 and fold change >1.5) and promotermethylation (FDR< 0.05) changes. (b,c). Example of a cluster (cluster1) of downregulated genes with similar differential methylation signaturesidentified during execution of the gene list tool in ref. 23. (b) Cluster1 location in a dendrogram of signatures arranged by shape. Greenbars denote downregulated genes; red bars denote upregulated genes.Cluster 1 highlighted in blue and with arrow. (c) A close-up view ofcluster 1, with gene names. Cluster 1 contains two replicates of the

RFC2 gene. (d) Three plots on the left: differential methylation versusposition up- and downstream of the transcription start site (TSS) (−5 kb(kilobases) to +5 kb) of RFC2 gene. The y axis is a differential methylationscore that ranges from −1 to 1, denoting complete hypomethylation andhypermethylation, respectively. The vertical dashed centre line marks theTSS. Fold change (log 2) gene expression is indicated in green. Data fromall three replicates are shown. Rightmost plot: relative CpG density aroundRFC2 gene TSS, plotted in red. (e) Average plot of differential methylation(green) versus position up- and downstream of TSS (−5 kb to +5 kb) for all136 downregulated genes in Supplementary Table 11 (three upregulatedgenes are excluded), smoothed over 100bp sliding windows. The left axisis average methylation difference, plotted in green. Units are in differentialmethylation (ranging from −1 to 1, as for a). The right axis is CpG density,plotted in red. Units are CpG sites per base pair. (f) Venn diagram showingoverlap of genes in Supplementary Tables 9 and 11. Overlap = 27.0-foldenrichment over random, P <0.0001.

shown previously28,29, on the basis of proliferation arrest, repression ofcyclin A and expression of SA β-gal (Supplementary Fig. 6a–d); andalso expression of satellite 2 and other chromatin changes characteristic

of senescence (specifically, appearance of SAHFs and recruitment ofhistone chaperone HIRA to PML nuclear bodies11,12; SupplementaryFig. 6e–g). A previous report showed that late-replicating sequences are

1498 NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

Pro

lif.

Sen

.

2.15

02.15

0

chr19: 10,110,000 10,130,000 10,150,000

DNMT1

20 kb5-

met

hylc

ytos

ine

(AIU

)

PD

26

PD

34

PD

45

Sen

.

Actin

DNMT1

Pro

lif.

Pro

lif.

Nea

r-se

n.

DAPI Cyclin A DNMT1

148

50

DNMT3B

Senescence

98

Per

cent

age

of r

elat

ive

DNMT1

mR

NA

0

Low

met

hylat

ion

Inter

med

iate

met

hylat

ion High

met

hylat

ion

20

40

60

80

100

800

Prolif.

Prolif.

Sen.

Sen.

Prolif.

Near-s

en.

Prolif.

Near-s

en.

Sen. +

2 w

ks

Sen. +

4 w

ks

900

1,000

1,100

1,200

1,300

1,400

1,500

0

20

Satellite 2 DNMT1

Merge

40

60

80

100

Per

cent

age

of c

yclin

A +

cel

lsw

ith D

NM

T1 fo

ci

0

10

20

30

40

50

Nea

r-se

n.

0

Per

cent

age

of c

yclin

A+

ce

lls w

ith

rep

licat

ion

foci

1020304050

ij

Per

cent

age

of c

yclin

A+

cel

ls

Mr (K)

cb

DAPI PCNA MergeSatellite 2

h

a ProliferatingNear-senescent

ge fd

Figure 3 DNA hypomethylation occurs before cell cycle exit and is associatedwith mislocalization of DNMT1. (a) Quantitation of 5-methylcytosine byimmunofluorescence in cyclin-A-positive (cyclin A+) proliferating andnear-senescent cells. See Supplementary Methods for definitions of Prolif,Near-sen and Sen. Low methylation denotes 900–1,700 average intensityunits, intermediate methylation 1,800–2,200 units and high methylation2,300–2,900 units. (b) Quantitation of 5-methylcytosine in proliferating(Prolif.), senescent (Sen.) and cells fixed 2 weeks and 4 weeks after onsetof senescence, Sen.+2wks and Sen.+4wks respectively. (c) Western blotof DNMT1, DNMT3B and actin across indicated cell population doublings(PDs) and senescent cells. Mr (K), relative molecular mass (thousands).(d) RNA sequencing (RNA-seq) analysis showing aligned reads (fragmentsper bp per million mapped reads) on DNMT1 gene in proliferating and

senescent cells. (e) Quantitative RT-PCR analysis of DNMT1 expression inproliferating and senescent cells normalized to expression of GAPDH as ahousekeeping gene. mRNA, messenger RNA. (f) Quantitation of proliferatingand near-senescent cyclin A-positive cells containing DNMT1 foci (fromg). (g) Immunofluorescence of DNMT1 and cyclin A in proliferating (Prolif)and near-senescent (Near-sen.) cells. Arrowheads mark DNMT1 puncta.DAPI, 4,6-diamidino-2-phenylindole. Scale bar, 5 µm. (h) Immuno-FISH ofsatellite 2 and DNMT1 with merge: DNMT1, red; satellite 2, green. Scalebar, 5 µm. (i) Immunofluorescence in situ hybridization (immuno-FISH) ofsatellite 2, PCNA and merge: PCNA, red; satellite 2, green. Scale bar, 5 µm.(j) Quantitation of proliferating and senescent cyclin A-positive cells thatcontain PCNA foci. Source data for a,b,e,f,j in Supplementary Table 22.Uncropped images of blots/gels are shown in Supplementary Fig. 8e.

progressively demethylated over cumulative cell divisions30. Our resultsshow that, in near-senescent cells, DNMT1 fails to localize normally tolate-replicating satellite 2 sequences, and this is associated with theirDNA hypomethylation.To test whether DNA hypomethylation was globally enriched at

late-replicating sequences, we compared regions of hypomethylationin senescent fibroblasts with early- and late-replicating sequences infibroblasts, using a data set generated previously31. This confirmedenrichment of hypomethylation at late-replicating sequences (Fig. 5a,band Supplementary Table 13). Conversely, there was depletion ofhypomethylation from early-replicating sequences (Fig. 5a,e and

Supplementary Table 13). Whereas hypermethylated regions coveredonly a small proportion of the genome (7.3% in hypermethylatedsDMRs), resulting in small absolute overlapwithmuch larger early- andlate-replicating regions, hypermethylation was significantly enrichedin early-replicating regions and depleted from late-replicating regions(Fig. 5a,c,d and Supplementary Table 13). Previous studies have shownco-localization of DNA replication sites in late S-phase with LADsand nuclear lamin B1 foci32–34. Indeed, there was enrichment ofhypomethylation at LADs (ref. 18), but a significant depletion ofhypermethylation (Fig. 5a,f,g and Supplementary Table 13). Early-replicating DNA sequences tend to be gene rich31, and approximately

NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013 1499

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

Senescence

PD26PD34

PD45Sen

.

PD26PD34

PD45Sen

.

DAPI MYC

88%

met

hyla

tion

55%

met

hyla

tion

Sat 2

GAPDH

RT+ + + + ––––

2D F

ISH

are

a

DAPI Satellite 2

Pro

lif.

Prolif.

Nea

r-se

n.P

rolif

.N

ear-

sen.

Near-s

en.

Prolif.

Near-s

en.

0

100

200

300

400

2D F

ISH

are

a

500

600

0

100

200

300

400

Pro

lifer

atin

gS

enes

cent

a

e f g

b c d

Figure 4 Hypomethylation and expression of late-replicating satellitesequences in senescent cells. (a) Bisulfite sequencing of satellite 2in proliferating and senescent cells. Each row represents an individualclone. Filled and open circles are methylated CpG and unmethylated CpGdinucleotides respectively. (b) Southern blot of genomic DNA with themethyl-sensitive enzyme BstBI probed with a probe specific for satellite2. Genomic DNA was harvested at different timepoints as cells approachsenescence as indicated by arrow. (c) FISH using a probe for satellite 2 in

proliferating and near-senescent cells. Scale bar, 5 µm. (d) Measurement oftwo-dimensional (2D) area occupied by the FISH probe from c. (e) RT-PCRof satellite 2 in IMR90 cells at indicated PD and senescence. (f) FISH usinga probe for MYC in proliferating and near-senescent cells as a negativecontrol for c. Scale bar, 5 µm. (g) Measurement of the two-dimensional areaoccupied by the MYC FISH probe in f. For all graphs, error bars indicatethe mean ± s.e.m. of three independent experiments where 100 cells werescored per experiment. Source data for d,g in Supplementary Table 22.

60% of gene promoters contain CpG islands. Accordingly, therewas an obvious enrichment of hypermethylation and depletionof hypomethylation at these sites (Fig. 5a,h,i and SupplementaryTable 13). Together, these results indicate that hypermethylation isfound preferentially at CpG islands. In contrast, hypomethylation insenescence occurs preferentially at gene-poor, late-replicating LADsand is linked tomislocalization ofDNMT1 in near-senescent cells.

Methylation changes in senescence resemble those in cancerThe widespread hypomethylation at late-replicating regions and LADs,as well as focal hypermethylation at CpG islands, are reminiscent ofmethylation changes previously reported in cancer1,3,35,36. In addition,aberrant transcription of satellite 2 has been noted in many cancercells37. Therefore, we directly addressed whether the gains and lossesof DNA methylation observed in senescence overlap with those incancer. Specifically, we compared sDMRs in IMR90 cells with cancer

DMRs (cDMRs) reported previously for colon and breast cancer3,35,36.Remarkably, when scored across the whole genome, we observedpartial but highly significant overlaps between altered methylationevents in cancer and senescence. Hypermethylated sDMRs wereenriched at hypermethylated cDMRs (Fig. 6a,b and SupplementaryTables 14, 15, 16). Similarly, hypomethylated sDMRs were enrichedat hypomethylated cDMRs, this being particularly marked for largerDMRs (Fig. 6a,c and Supplementary Fig. 6h and SupplementaryTables 14, 15, 16). Conversely, hypermethylated sDMRs weredepleted from hypomethylated cDMRs (Fig. 6a,d and SupplementaryTables 14, 15, 16), and hypomethylated sDMRs were depleted fromhypermethylated cDMRs (Fig. 6a,e and Supplementary Tables 14, 15,16). More specifically, several CpG islands whose hypermethylationwas previously reported to predict a cancer CpG island methylatorphenotype showed small increases in methylation in senescence(namely, RUNX3, CACNA1G, SFRP2, SOCS1 and NEUROG1;

1500 NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

Chr 10

Percentage methylation

100

200 10 Mb

–200

15

0

0

0

Early rep.

Difference p

Late rep.

Lamin B1

Genes

CpG islands

Per

cent

age

of la

te-r

ep.

over

lap

with

hyp

o.

0

Random

Observ

ed

Random

Observ

ed

Random

Observ

ed

10

20

30

40

50

60

70

80

90∗

∗ ∗ ∗ ∗

∗ ∗ ∗100

Per

cent

age

of la

te-r

ep.

over

lap

with

hyp

er.

0

10

20

30

40

50

60

70

80

90

100

Per

cent

age

of e

arly

-rep

. ov

erla

p w

ith h

yper

.

0

10

20

30

40

50

60

70

80

90

100

Random

Observ

ed

Per

cent

age

of e

arly

-rep

. ov

erla

p w

ith h

ypo.

0

10

20

30

40

50

60

70

80

90

100

Per

cent

age

of L

AD

s ov

erla

p

with

hyp

o.

Random

Observ

ed0

10

20

30

40

50

60

70

80

90

100

Per

cent

age

of L

AD

s ov

erla

p

with

hyp

er.

Random

Observ

ed

Random

Observ

ed

Random

Observ

ed0

10

20

30

40

50

60

70

80

90

100

Per

cent

age

of C

pG

l ove

rlap

w

ith h

yper

.

Per

cent

age

of C

pG

l ove

rlap

w

ith h

ypo.

0

10

20

30

40

50

60

70

80

90

100

0

10

20

30

40

50

60

70

80

90

100

a

b c d e

f g h i

Figure 5 Hypomethylation occurs at gene-poor, late-replicating andlamin-associated domains whereas hypermethylation occurs at gene-rich,early-replicating regions and CpG islands. (a) Plot of a 43.5Mb(megabase) region of chromosome 10 (chr 10) percentage methylationof proliferating (blue) and senescent (orange) cells with difference P(Fig. 1e). Normalized enrichment of lamin B1 determined by chromatin

immunoprecipitation sequencing of proliferating IMR90 cells is shown.Early- and late-replicating sequences from31 are annotated. Genes and CpGislands are from UCSC. (b–i) Plots showing percentage overlap in total basepairs of indicated features across the whole genome, comparing observedand random predicted values. Asterisks indicate statistical significanceand P <0.001.

refs 38,39; Fig. 6f and Supplementary Fig. 7 and SupplementaryTable 17). Interestingly, the promoter of CDKN2A (p19) did notshow increased methylation within the CpG island itself, but a markedincrease in the flanking regions either side (Supplementary Fig. 7). CpGisland ‘shores’, close to designated islands, are themselves often targetsof increased methylation in cancer40. In addition, we noted increased

methylation within the CpG islands of two genes, ESX1 and IRAK3(ref. 41), whose expression is incompatible with cancer cell survival(Supplementary Fig. 7 and Table 17).Replicative senescence is a barrier to cell transformation8,9. In the

process of malignant transformation, immortal cancer cells mustevade replicative senescence. Our results suggest that features of the

NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013 1501

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

Chr 16

200 5 Mb

–200

0

Percentage methylation

Difference p

HansenHypo.cDMR

Hyper.cDMR

Berman

Hon

Hansen

Berman

Hon

Genes

CpG islands

Per

cena

tge

of h

yper

. cD

MR

ove

rlap

w

ith h

yper

. sD

MR

Per

cent

age

of h

yper

. cD

MR

ove

rlap

w

ith h

ypo.

sD

MR

Per

cent

age

of h

ypo.

cD

MR

ove

rlap

w

ith h

ypo.

sD

MR

(5

00 k

b D

MR

s on

ly)

Per

cent

age

of h

ypo.

cD

MR

ove

rlap

w

ith h

yper

. sD

MR

0

Random

Observ

ed

Random

Observ

ed

Random

Observ

ed

Random

Observ

ed

20

80NEUROG1, chr 5, CpG1 134, 898, 640–134, 899, 950

40

Per

cent

age

met

hyla

tion

20

01 kb hg18

134,898,500 134,899,000 134,899,500NEUROG1

134,900,000 134,900,500

TSS

40

60

0

20

40

60

0

20

40

60

0

20

40

60

∗ ∗ ∗ ∗

a

b

f

c d e

100

0

Figure 6 Methylation changes in senescence resemble those in cancer.(a) Plot of a 13.5Mb region of chromosome 16 (chr 16) with percentagemethylation in proliferating (blue) and senescent (orange) cells anddifference p (Fig. 1e). Genes and CpG islands are shown. Hypomethylatedand hypermethylated DMRs from colon and breast cancer, hypo. cDMR andhyper. cDMR respectively, are mapped from3,35,36. (b–e) Plots of percentageoverlap in total base pairs of indicated features across whole genome,comparing observed and random predicted values; cDMRs taken fromref. 36. Asterisks indicate statistical significance and P -value � 0.001.(f) Increased methylation of neurogenin 1 (NEUROG1) CpG island in

senescence. Plot of percentage methylated basecalls in proliferating(orange) and senescent cells (blue), at the NEUROG1 gene, fromwhole-genome bisulfite sequencing data of three replicates of proliferatingcells and three replicates of senescent cells. The orange and bluelines show the smoothed average percentage methylated basecalls atcorresponding CpGs. Individual CpGs are indicated by black ticks alongthe x axis. The UCSC NEUROG1 gene (blue bar (hatched, exon 1)) andCpG island (green bar) are also shown. The TSS is indicated by a verticalblack arrow. The gene, chromosome and bp of the CpG island are indicatedat the top left.

1502 NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

50

Con

trol

SV

40

SV40 T antigen

β actin

92

90

88

86

Pop

ulat

ion

dou

blin

gs

84

82

800

Chr 16

Proliferatingpercentage methylation

Senescentpercentage methylation

Bypasspercentage methylation

Difference pSen.–Prolif.

Difference pBypass–Prolif.

Difference pBypass–Sen.

100

1000

1000

020 Mb

p13.3 13.2 12.3 p12.1 16p11.2

20 40 60Days

ControlSV40

80 100

q11.2 q23.116q21q12.1 22.1 22.313

100

80

60

Byp

ass

40

20

0

100

80

60

Byp

ass

40

20

0

1008060Proliferating40200 1008060

Senescent40200

a

c

d

b

Mr (K)

Figure 7 Altered methylation is retained in cells that bypass senescence.(a) Three replicates of IMR90 cells approaching senescence (PD 80;Supplementary Fig. 1a) were infected with a control lentivirus or alentivirus encoding SV40 T antigen. Mr (K), relative molecular mass(thousands). (b) SV40 T antigen-expressing cells exhibit extension oflifespan (bypass). (c) DNA was collected for whole-genome bisulfitesequencing from bypass cells at PD 84. Plot of chromosome 16 (chr16) with percentage methylation for proliferating, senescent and bypass

cells. Difference P is proportional to the p value difference betweenmethylation of proliferating and senescent cells (difference P , Sen. −Prolif.), proliferating and bypass cells (difference P , Bypass − Prolif.) andsenescent versus bypass cells (difference P , Bypass − Sen.). Negativeand positive values are hypomethylation and hypermethylation respectively.(d) Plot of percentage methylation in 2 kb windows encompassing wholegenome, comparing either bypass against proliferating cells (left) or bypassagainst senescent cells (right).

cancer methylome can be present in premalignant senescent cells,and perhaps propagated into cancer cells on escape from senescence.To test this, IMR90 cells approaching senescence were infected witha lentivirus encoding simian virus 40 (SV40) large T antigen to

inactivate pRB and p53 and promote bypass of senescence (Fig. 7a,b),generating proliferating senescence ‘bypass’ cells (SupplementaryFig. 8a–c). Whole-genome bisulfite sequencing was carried out onbypass cells. The profile of DNA methylation in senescent cells was

NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013 1503

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

largely retained in bypass cells (Fig. 7c, top three tracks). Consequently,the difference between bypass and proliferating cells resembledthe difference between senescent and proliferating cells, and thedifferences between bypass and senescent cells were less marked(Fig. 7c). Underscoring this, there was strong overall concordancebetween methylation in senescent cells and in bypass cells (Pearsonr = 0.955), but poorer concordance between proliferating cells andbypass cells (Pearson r = 0.900; Fig. 7d). When DMRs were definedrelative to proliferating cells, hypomethylated sDMRs significantlyoverlapped with hypomethylated bypass DMRs, and the same was truefor hypermethylated DMRs (Supplementary Table 18). For example,88.7% of hypomethylated sDMRs (>500 kb) are also observed inbypass cells (predicted random overlap = 26.4%) (SupplementaryTable 18). Importantly, methylation changes retained in bypass cellswere enriched for methylation changes in cancer (SupplementaryTables 19–21). For example, 88.4% of hypomethylated sDMRs thatare retained in bypass cells are also observed in colon cancer cells(predicted random overlap= 39.6%; Supplementary Table 19, row 19).Specific CpG islands known to be methylated in cancer and shown hereto acquire DNA methylation in senescence (CpG island methylatorphenotype genes, ESX1, IRAK3), typically retained significant elevationof methylation in bypass cells (Supplementary Table 17). These dataindicate that altered methylation acquired in senescent cells can beretained when these cells bypass senescence.

DISCUSSIONHere we have shown that senescent cells harbour extensive changes toDNA methylation, compared with proliferating cells. First, senescentcells exhibit widespread hypomethylation in late-replicating, gene-poorregions, including pericentromeric satellites and LADs. As normalcells approach their proliferative limit, altered regulation of DNMT1is linked to DNA hypomethylation of these regions, and associatedexpression of satellite 2 repeats. Several recent studies underscore LADsas central to changes in nuclear and chromatin structure in senescentcells17,18,42. Whereas knockdown of DNMT1 triggered prematuresenescence, we failed to observe delayed senescence on its ectopicexpression. Conceivably, DNA hypomethylation of late-replicatingregions is a sufficient trigger or effector of senescence, but is alsoredundant with other independent senescence triggers and effectors4.Suppression of DNMT1 may also trigger senescence by activationof DNA damage signalling43. Second, in senescent cells, a subset ofrepressed cell cycle genes exhibits increased DNA methylation atpromoter-proximal regions either side of theCpG island. At these genes,DNA methylation might contribute to repression and so senescence-associated cell cycle exit and stable proliferation arrest40. Finally,increased methylation in senescent cells occurs disproportionatelywithin CpG islands, regions that are typically free of DNA methylation.The physiological function of this low-level methylation is unclear,especially at genes whose CpG island methylation is thought tocontribute to cancer, such as SFRP2 and IRAK3 (refs 41,44); in fact,here methylation may reflect a form of ‘epigenetic damage’ in stressedsenescent cells (see below). Increases inDNAmethylationmight involveDNMTs other than DNMT1, such as the de novo methyltransferaseDNMT3B (refs 25,45,46; Fig. 3c).Our data support the view that altered methylation in cancer does

not necessarily result from genetic alterations. Instead, features of

Methylation spreading

Limited escape from senescence

Extension of proliferative lifespan

Gene silencing

Mislocalization of DNMT1

CpG island methylation:

Tumour suppressor gene expression potential:

Widespread hypomethylation (for example at late-replicating LADs):

CancerYoung tissue Aged tissue

Non-senescent Senescent Cancer

Figure 8 The altered epigenome of senescent cells might promoteage-associated increase in incidence of human cancers. Our analysesand previous studies and ideas62 lead to the following model. Senescentcells accumulate with age in human tissues59. These senescent cellsharbour low-level methylation of CpG islands of tumour suppressorgenes that is insufficient to silence gene expression. However, even alimited/transient escape from senescence, for example owing to geneticinactivation of PTEN63,64, confers further rounds of cell division that permitsproliferation-dependent spreading of DNA methylation51. Hence, an initial‘seed’ of methylation in a senescent cell in an aged tissue can, in conjunctionwith other genetic alterations and clonal selection, grow to full CpG islandhypermethylation and tumour suppressor gene silencing, thereby facilitatingprogression to late-life cancer. Global hypomethylation in senescent cellsmay also promote genome instability and dysfunction3,47,48,55–58.

the cancer methylome can originate in premalignant senescent cells,and be propagated into cancer cells on bypass of senescence. As cellsprogress to malignant cancer, acquired genetic changes and clonalselection will further mould the epigenome, probably leading to somedifferences between the epigenomes of senescent cells reported hereand cancer cells35. Cancer cells might also acquire methylation changesindependent of any alteredmethylation associatedwith senescence.Both global hypomethylation and CpG island hypermethylation

are thought to promote cancer1,2,37,47,48. Remarkably, some of themethylation changes observed in senescence are similar to thosereported in cancer. In senescent cells, the extent of CpG islandhypermethylation of CpG island methylator phenotype genes (andother genes silenced in cancer, such as ESX1 and IRAK3) is small andprobably not sufficient for transcription repression. However, we havealso shown here that that altered methylation acquired in senescentcells can be retained in cells that bypass senescence. In such cells, andin the appropriate genetic context and tissue environment, low-levelmethylation in and around CpG islands of tumour suppressor genes,such as CDKN2A (p14), IRAK3 and SFRP2, might be a seed to promotefurther hypermethylation and perhaps silencing49–51. Consistent withthis idea, upregulation of DNMT3B is also associated with methylationof CpG islands in early stages of human colon cancer (for examplehyperplastic polyps and adenomas)52,53. In a mouse model of mutantBRAF-induced colon cancer, upregulation of DNMT3B is associatedwith onset of cell senescence, and ultimately methylation of the CpGisland of CDKN2A (p16), downregulation of p16 expression, bypass

1504 NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

of senescence, and progression to cancer54. As hypomethylation isalso a driver of genome instability and cancer47,48, senescent cells thatevade proliferation arrest might already harbour an unstable genome.Moreover, hypomethylation is expected to facilitate expression andtransposition of retrotransposons that further destabilize the cancergenome55–57. Indeed, increased transcription of retroelements insenescent human cells has been reported58. In sum, whereas senescenceis a bona fide tumour suppression mechanism4–9, if senescent cells canescape their proliferative barrier, they already harbour an epigeneticlandscape likely to promote malignancy. As senescent cells accumulatewithin aged tissues59–61, the altered epigenome of senescent cells mightfacilitate late-life onset of many human cancers62 (Fig. 8). �

METHODSMethods and any associated references are available in the onlineversion of the paper.

Note: Supplementary Information is available in the online version of the paper

ACKNOWLEDGEMENTSThanks to S. Pepper in the CRUKmicroarray facility and to S. Hansen for assistancewith DNA replication timing data. Thanks to Beijing Genome Institute for bisulfitesequencing. Work in the laboratory of P.D.A. was funded by NIA Program ProjectP01 AG031862 and CRUK Program A10250. S.L.B.’s laboratory was funded by NIAProgram Project P01 AG031862. R.R.M.’s laboratory was funded by the MRC andthe BBSRC. P.D.A. thanks P. Cairns for critical formative discussions.

AUTHOR CONTRIBUTIONSH.A.C. carried out the bulk of the experiments. D.M.N., P.P.S., J.v.T., T.S.R., C.B.,M.E.D. and D.S.D. carried out further experiments. T.M. carried out the bulk ofthe data analysis. N.D.V. and G.D. carried out further data analyses. H.A.C. andT.M. provided substantial and critical intellectual input. R.R.M., J.R.E. and S.L.B.provided further intellectual input. P.D.A., H.A.C. and T.M. conceived the projectand wrote the manuscript.

COMPETING FINANCIAL INTERESTSThe authors declare no competing financial interests.

Published online at www.nature.com/doifinder/10.1038/ncb2879Reprints and permissions information is available online at www.nature.com/reprints

1. Ting, A. H., McGarvey, K. M. & Baylin, S. B. The cancer epigenome–components andfunctional correlates. Genes Dev. 20, 3215–3231 (2006).

2. Sproul, D. & Meehan, R. R. Genomic insights into cancer-associated aberrant CpGisland hypermethylation. Brief Funct. Genomic. 12, 174–190 (2013).

3. Hon, G. C. et al. Global DNA hypomethylation coupled to repressive chromatindomain formation and gene silencing in breast cancer. Genome. Res. 22,246–258 (2012).

4. Kuilman, T., Michaloglou, C., Mooi, W. J. & Peeper, D. S. The essence of senescence.Genes Dev. 24, 2463–2479 (2010).

5. Michaloglou, C. et al. BRAFE600-associated senescence-like cell cycle arrest ofhuman naevi. Nature 436, 720–724 (2005).

6. Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression ofPten-deficient tumorigenesis. Nature 436, 725–730 (2005).

7. Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphomadevelopment. Nature 436, 660–665 (2005).

8. Feldser, D. M. & Greider, C. W. Short telomeres limit tumour progression in vivo byinducing senescence. Cancer Cell 11, 461–469 (2007).

9. Cosme-Blanco, W. et al. Telomere dysfunction suppresses spontaneous tumorige-nesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 8,497–503 (2007).

10. Choi, M. R. et al. Genome-scale DNA methylation pattern profiling of humanbone marrow mesenchymal stem cells in long-term culture. Exp. Mol. Med. 44,503–512 (2012).

11. Narita, M. et al. Rb-mediated heterochromatin formation and silencing of E2F targetgenes during cellular senescence. Cell 113, 703–716 (2003).

12. Zhang, R. et al. Formation of MacroH2A-containing senescence-associatedheterochromatin foci and senescence driven by ASF1a and HIRA. Dev. Cell 8,19–30 (2005).

13. O’Sullivan, R. J., Kubicek, S., Schreiber, S. L. & Karlseder, J. Reduced histonebiosynthesis and chromatin changes arising from a damage signal at telomeres. Nat.Struct. Mol. Biol. 17, 1218–1225 (2010).

14. Wilson, V. L. & Jones, P. A. DNA methylation decreases in ageing but not in immortalcells. Science 220, 1055–1057 (1983).

15. Schellenberg, A. et al. Replicative senescence of mesenchymal stem cells causesDNA-methylation changes which correlate with repressive histone marks. Aging 3,873–888 (2011).

16. Chandra, T. et al. Independence of repressive histone marks and chromatincompaction during senescent heterochromatic layer formation. Mol. Cell 47,203–214 (2012).

17. Sadaie, M. et al. Redistribution of the Lamin B1 genomic binding profile affectsrearrangement of heterochromatic domains and SAHF formation during senescence.Genes Dev. 27, 1800–1808 (2013).

18. Shah, P. P. et al. Lamin B1 depletion in senescent cells triggers large-scalechanges in gene expression and the chromatin landscape. Genes Dev. 27,1787–1799 (2013).

19. Forsyth, N. R., Evans, A. P., Shay, J. W. & Wright, W. E. Developmentaldifferences in the immortalization of lung fibroblasts by telomerase. Aging Cell 2,235–243 (2003).

20. Coppe, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. The senescence-associatedsecretory phenotype: the dark side of tumour suppression. Annu. Rev. Pathol. 5,99–118 (2010).

21. Young, J. I., Sedivy, J. M. & Smith, J. R. Telomerase expression in normal humanfibroblasts stabilizes DNA 5-methylcytosine transferase I. J. Biol. Chem. 278,19904–19908 (2003).

22. Lister, R. et al. Human DNA methylomes at base resolution show widespreadepigenomic differences. Nature 462, 315–322 (2009).

23. Vanderkraats, N. D., Hiken, J. F., Decker, K. F. & Edwards, J. R. Discoveringhigh-resolution patterns of differential DNA methylation that correlate with geneexpression changes. Nucleic Acids Res. 41, 6816–6827 (2013).

24. Leonhardt, H., Page, A. W., Weier, H. U. & Bestor, T. H. A targeting sequence directsDNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71,865–873 (1992).

25. Lopatina, N. et al. Differential maintenance and de novo methylating activity by threeDNA methyltransferases in ageing and immortalized fibroblasts. J. Cell Biochem. 84,324–334 (2002).

26. Suzuki, T., Fujii, M. & Ayusawa, D. Demethylation of classical satellite 2 and 3DNA with chromosomal instability in senescent human fibroblasts. Exp. Gerontol.37, 1005–1014 (2002).

27. Enukashvily, N. I., Donev, R., Waisertreiger, I. S. & Podgornaya, O. I. Humanchromosome 1 satellite 3 DNA is decondensed, demethylated and transcribed insenescent cells and in A431 epithelial carcinoma cells. Cytogenet. Genome. Res.118, 42–54 (2007).

28. Yamakoshi, K. et al. Real-time in vivo imaging of p16Ink4a reveals cross talk withp53. J. Cell Biol. 186, 393–407 (2009).

29. Young, J. I. & Smith, J. R. DNA methyltransferase inhibition in normal humanfibroblasts induces a p21-dependent cell cycle withdrawal. J. Biol. Chem. 276,19610–19616 (2001).

30. Aran, D., Toperoff, G., Rosenberg, M. & Hellman, A. Replication timing-relatedand gene body-specific methylation of active human genes. Hum. Mol. Genet. 20,670–680 (2011).

31. Hansen, R. S. et al. Sequencing newly replicated DNA reveals widespread plasticityin human replication timing. Proc. Natl Acad. Sci. USA 107, 139–144 (2010).

32. Moir, R. D., Montag-Lowy, M. & Goldman, R. D. Dynamic properties of nuclearlamins: lamin B is associated with sites of DNA replication. J. Cell Biol. 125,1201–1212 (1994).

33. Peric-Hupkes, D. et al. Molecular maps of the reorganization of genome-nuclearlamina interactions during differentiation. Mol. Cell 38, 603–613 (2010).

34. Yaffe, E. et al. Comparative analysis of DNA replication timing reveals conservedlarge-scale chromosomal architecture. PLoS Genet. 6, e1001011 (2010).

35. Berman, B. P. et al. Regions of focal DNA hypermethylation and long-rangehypomethylation in colorectal cancer coincide with nuclear lamina-associateddomains. Nat. Genet. 44, 40–46 (2012).

36. Hansen, K. D. et al. Increased methylation variation in epigenetic domains acrosscancer types. Nat. Genet. 43, 768–775 (2011).

37. Ting, D. T. et al. Aberrant overexpression of satellite repeats in pancreatic and otherepithelial cancers. Science 331, 593–596 (2011).

38. Toyota, M. et al. CpG island methylator phenotype in colorectal cancer. Proc. NatlAcad. Sci. USA 96, 8681–8686 (1999).

39. Weisenberger, D. J. et al. CpG island methylator phenotype underlies sporadicmicrosatellite instability and is tightly associated with BRAF mutation in colorectalcancer. Nat. Genet. 38, 787–793 (2006).

40. Irizarry, R. A et al. The human colon cancer methylome shows similar hypo- andhypermethylation at conserved tissue-specific CpG island shores. Nat. Genet. 41,178–186 (2009).

41. De Carvalho, D. D. et al. DNA methylation screening identifies driver epigeneticevents of cancer cell survival. Cancer Cell 21, 655–667 (2012).

42. Shimi, T. et al. The role of nuclear lamin B1 in cell proliferation and senescence.Genes Dev. 25, 2579–2593 (2011).

NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013 1505

© 2013 Macmillan Publishers Limited. All rights reserved.

ART I C L E S

43. Unterberger, A., Andrews, S. D., Weaver, I. C. & Szyf, M. DNA methyltransferase1 knockdown activates a replication stress checkpoint. Mol. Cell Biol. 26,7575–7586 (2006).

44. Suzuki, H. et al. Epigenetic inactivation of SFRP genes allows constitutive WNTsignalling in colorectal cancer. Nat. Genet. 36, 417–422 (2004).

45. Zhang, W. et al. Comparison of global DNA methylation profiles in replicative versuspremature senescence. Life Sci. 83, 475–480 (2008).

46. Casillas, M. A. Jr., Lopatina, N., Andrews, L. G. & Tollefsbol, T. O. Transcriptionalcontrol of the DNA methyltransferases is altered in ageing and neoplastically-transformed human fibroblasts. Mol. Cell Biochem. 252, 33–43 (2003).

47. Eden, A., Gaudet, F., Waghmare, A. & Jaenisch, R. Chromosomal instability andtumours promoted by DNA hypomethylation. Science 300, 455 (2003).

48. Gaudet, F. et al. Induction of tumours in mice by genomic hypomethylation. Science300, 489–492 (2003).

49. Song, J. Z., Stirzaker, C., Harrison, J., Melki, J. R. & Clark, S. J. Hypermethylationtrigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.Oncogene 21, 1048–1061 (2002).

50. Landan, G. et al. Epigenetic polymorphism and the stochastic formation ofdifferentially methylated regions in normal and cancerous tissues. Nat. Genet. 44,1207–1214 (2012).

51. O’Hagan, H. M., Mohammad, H. P. & Baylin, S. B. Double strand breaks can initiategene silencing and SIRT1-dependent onset of DNA methylation in an exogenouspromoter CpG island. PLoS Genet. 4, e1000155 (2008).

52. Ibrahim, A. E. et al. Sequential DNA methylation changes are associatedwith DNMT3B overexpression in colorectal neoplastic progression. Gut 60,499–508 (2011).

53. Nosho, K. et al. DNMT3B expression might contribute to CpG island methylatorphenotype in colorectal cancer. Clin. Cancer Res. 15, 3663–3671 (2009).

54. Carragher, L. A. et al. V600EBraf induces gastrointestinal crypt senescence andpromotes tumour progression through enhanced CpG methylation of p16INK4a.EMBO Mol. Med. 2, 458–471 (2010).

55. Walsh, C. P., Chaillet, J. R. & Bestor, T. H. Transcription of IAP endogenous retro-viruses is constrained by cytosine methylation. Nat. Genet. 20, 116–117 (1998).

56. O’Neill, R. J., O’Neill, M. J. & Graves, J. A. Undermethylation associated withretroelement activation and chromosome remodelling in an interspecific mammalianhybrid. Nature 393, 68–72 (1998).

57. Lee, E. et al. Landscape of somatic retrotransposition in human cancers. Science337, 967–971 (2012).

58. De Cecco, M. et al. Genomes of replicatively senescent cells undergo globalepigenetic changes leading to gene silencing and activation of transposable elements.Aging Cell 12, 247–256 (2013).

59. Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture andin ageing skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995).

60. Herbig, U., Ferreira, M., Condel, L., Carey, D. & Sedivy, J. M. Cellular senescence inageing primates. Science 311, 1257 (2006).

61. Sedelnikova, O. A. et al. Senescing human cells and ageing mice accumulateDNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 6,168–170 (2004).

62. Feinberg, A. P., Ohlsson, R. & Henikoff, S. The epigenetic progenitor origin of humancancer. Nat. Rev. Genet. 7, 21–33 (2006).

63. Vredeveld, L. C. et al. Abrogation of BRAFV600E-induced senescence byPI3K pathway activation contributes to melanomagenesis. Genes. Dev. 26,1055–1069 (2012).

64. Kennedy, A. L. et al. Activation of the PIK3CA/AKT pathway suppresses senescenceinduced by an activated RAS oncogene to promote tumorigenesis. Mol. Cell 42,36–49 (2011).

1506 NATURE CELL BIOLOGY VOLUME 15 | NUMBER 12 | DECEMBER 2013

© 2013 Macmillan Publishers Limited. All rights reserved.

DOI: 10.1038/ncb2879 METHODS

METHODSSource data for several analyses are provided in Supplementary Table 22.

Cell culture. IMR90 cells (Coriell) were grown in DMEM, high glucose (LifeTechnologies) supplemented with 20% fetal bovine serum, 2mM l-glutamine and100 µgml−1 penicillin–streptomycin and incubated at 37 ◦C with 20% (v/v) or 3%(v/v) O2 and 5% (v/v) CO2. Bisulfite sequencing was carried out on cells grown in3% (v/v) O2. Global DNA hypomethylation was also observed in 20% (v/v) O2 (forexample Figs 1a and 4b), and other experiments were carried out on cells grownunder these conditions. Proliferating cells were PD 20–28 in 3% (v/v) or 20% (v/v)O2, near-senescent cells were PD 54 in 20% (v/v) O2 and senescent cells were PD 59in 20% (v/v) O2 and PD 88 in 3% (v/v) O2.

Antibodies and short hairpin RNAs (shRNAs). See Supplementary Table 23.

Generation and production of lentiviruses. For bypass of senescence, a SINhuman immunodeficiency virus I (lenti-) vector expressing the early region of SV40from the cytomegalovirus promoter and the gene encoding neomycin resistance,driven by the SV40 early promoter, was generated. Production of lentivectors andinfection of IMR90 were carried out as described65. Infected cells were cultured inthe presence of 500 µgml−1 G418 sulfate (Invitrogen) for one week.

Immunofluorescence. Immunofluorescence was carried out broadly as de-scribed previously12. For staining with anti-5-methylcytosine, cells were fixed inparaformaldehyde and permeabilized with 0.2% (v/v) Triton X-100 in PBS (pH 7.5)for 2min at room temperature, then incubated in 2NHCl for 45min at 37 ◦C to de-nature DNA. DNA was counterstained with an antibody to ssDNA in place of DAPI.Staining intensities were quantified usingMetaMorph software (Molecular Devices).

Senescence-associated β-galactosidase staining. Carried out as described inref. 66.

RT-PCR. Total RNA was extracted from cells using TRIzol (Life Technologies)according to the manufacturer’s instructions. Before reverse transcription, totalRNA samples were DNase I treated as recommended by the manufacturer (LifeTechnologies). Reverse-transcription reactions were carried out using SuperScriptIII (Life Technologies) following the manufacturer’s protocol, using 1 µg of DNaseI-treated total RNA as template. 1 µl of first-strand complementary DNA wasused as a template for PCR. PCR conditions were as follows: 1× PCR buffer,0.2mM deoxynucleotide triphosphates (Life Technologies), 0.25 µM forwardprimer, 0.25 µM reverse primer and 1.25U Taq polymerase (Life Technologies).PCR reactions were incubated at 95 ◦C for 5min followed by 30 cycles of 95 ◦C for30 s, appropriate annealing temperature (primer pair dependent) for 30 s and 72 ◦Cfor 30 s, with a final incubation at 72 ◦C for 10min. PCR products were analysed onan agarose gel. For quantitative RT-PCR, reverse-transcription reactions were set upas described above; 2 µl of reaction was used as a template for real-time PCR usinginventoried TaqMan probes (Applied Biosystems) according to the manufacturer’sinstructions using a Chromo 4 real-time PCR machine (Bio-Rad).

Gene expression array. RNA samples prepared as above were hybridized to aHuman Genome U133 Plus 2.0 array (Affymetrix) according to the manufacturer’srecommendations and as reported previously18.

RNA-seq. RNA-seq was carried out on an Illumina GAIIx instrument, according tothe manufacturer’s instructions. Full results of RNA-seq will be reported elsewhere.

FISH. Cells grown on coverslips were hypotonically treated in 75mM KCl for20min. Cells were fixed by adding drops of methanol:acetic acid (3:1), and finallyincubated overnight inmethanol:acetic acid (3:1) at−20 ◦C. The next day, coverslipswere removed from fixative, steam dried and incubated in 100 µgml−1 RNase Ain 2× saline–sodium citrate (SSC; pH 7.0) for 1 h at 37 ◦C. Following washes in2× SSC, cover slips were incubated for 6min at 37 ◦C in 0.1mgml−1 pepsin inacidic conditions. Following pepsin treatment, cells were post-fixed in 1% (w/v)parafomaldehyde. Subsequently, cells were dehydrated by successive incubationsin 70%, 80% and 100% ethanol and dried. Once dried they were denatured byincubation in 70% (v/v) formamide and 2× SSC at 73 ◦C for 5min, dehydratedand dried as previously. Probes for FISH were prepared for hybridization accordingto the manufacturers’ recommendations (Vysis and Exiqon), denatured at 73 ◦Cfor 5min and pre-annealed for 1 h at 37 ◦C. Probes were applied to coverslips andincubated at 37 ◦Covernight. The following day coverslips were washed twice in 50%(v/v) formamide in 2×SSC for 10min at 43 ◦C, washed twice in 2×SSC at 37 ◦C for4min, washed with 2×SSC with DAPI for 4min at room temperature and finallywashed with 4× SSC with 0.05% (v/v) Tween-20 for 5min at room temperature.Slides weremountedwith ProlongGold (Life Technologies) and sealed. For co-FISHwith an immunofluorescent stain for protein of interest, cells were fixed as above and

antibody staining was carried out as described. Following antibody staining, cellswere post-fixed and treated as above with the omission of pepsin treatment. Areas ofFISH probe signal were quantified using MetaMorph software (Molecular Devices).

Western blotting. Carried out as described67. Uncropped western blots are shownin Supplementary Fig. 8d–e.

Methylation-sensitive Southern blotting. 1 µg of genomic DNA was digestedusing the BstBImethyl-sensitive endonuclease. Fragments were separated by agarosegel electrophoresis and DNA was transferred onto a nylon membrane (Bio-Rad) byupward capillary motion in 0.4M NaOH. DNA was immobilized on the membraneby baking at 80 ◦C. Blots were hybridized with a 32P-radiolabelled probe specific tothe sequence of interest in hybridization solution (3× SSC, 10mM EDTA, 0.2%(w/v) polyvinylpyrrolidone, 0.2% (w/v) Ficoll, 0.2% (w/v) BSA, 0.1% (w/v) SDS,0.04mgml−1 salmon sperm DNA and 0.02mgml−1 heparin, 9% (w/v) dextransulfate). The following day, blots were washed in 2×SSC/0.1% (w/v) SDS twice for5min at room temperature and twice in 0.1× SSC/0.1% (w/v) SDS for 15min at65 ◦C. Membranes were exposed to autoradiograph film (Kodak) for imaging.

Lamin B1 chromatin immunoprecipitation sequencing. Carried out aspreviously described18.

Bisulfite sequencing. 500 ng of genomic DNA was bisulfite treated using an EZDNA Methylation Gold kit following the manufacturer’s recommendations (ZymoResearch). Following treatment, PCR was carried out using conditions as above.Products were then directly cloned into pCR2.1 TA cloning vector following themanufacturer’s protocol (Life Technologies) and those positive for inserts weresequenced.

Whole-genome bisulfite sequencing. Carried out by BGI, Shenzhen.

Representative experiments. All data shown as representative experiments, forexample western blots and immunofluorescence, were repeated as shown at leastthree times.

Data analysis/statistics. Processing and alignment of bisulfite sequencing reads.Sequence reads are transformed in silico to fully bisulfite-converted forward (C→T)and reverse (G→A) reads. The converted sequences are aligned against a convertedhuman reference genome (hg18) in each combination: (1) forward (C→ T) readsaligned to forward (C→ T) genome; (2) reverse (G→A) reads aligned to reverse(G→A) genome; (3) forward (C→ T) reads aligned to reverse (G→A) genome;(4) reverse (G→A) reads aligned to forward (C→ T) genome. During the librarypreparation process68, genomic fragments representing alignments (3) and (4) aregenerated in the PCR step; however, they are not sequenced and only fragmentscorresponding to alignments (1) and (2) are read. As a result, only uniquelymatching alignments from (1) and (2) are retained. Alignment was carried out usingBismark69 (version 0.5.1), based on the Bowtie68 aligner (version 0.12.7). Unalignedreads resulting from the initial alignments from these libraries were trimmed 15 bpfrom the 5′ end to remove the adapter sequences, as some libraries contained thesesequences and realigned.

For each aligned sequence tag, the original unconverted sequence is comparedagainst the original unconverted reference genome and the methylation status isinferred. Sequences aligned from (1) and (2) give information on cytosines on theforward and reverse strands respectively.

To remove PCR bias, a deduplication step removes potential duplicate reads,where both ends of the fragment align to the same genomic positions on the samestrand, only one of the reads is retained. To control for potential incomplete bisulfitetreatment any readswithmore than threemethylated cytosines in non-CpG contextsare discarded. Supplementary Table 1 details the sequence yields at each stage of thisprocess. Supplementary Tables 2, 5 and 6 detail the number of methylated and un-methylated bases sequenced within CpG, CHG and CHH contexts (H=A, C or T).

Furthermore, reads aremapped against the unmethylated lambda genome, whichwas added to bisulfite sequencing reactions, giving the number of methylated bases,enabling the combined error rate resulting from sequencing errors and incompletebisulfite conversion (Supplementary Table 7) to be determined.

Identification of methylated cytosines. Processed reads are aggregated on a perCpG basis (number of bases read supporting methylated/unmethylated status). Ateach reference cytosine the binomial distribution was used to identify whethera subset of the genomes within the sample were methylated at this location.Methylcytosines were identified while keeping the number of false positives below1%. The probability of sequencing an observed number of cytosines given theidentified error rates from the lambda alignment was determined using the binomialdistribution. At each reference cytosine the number of trials in the binomial test wasthe read depth and the number of successes in the test was equal to the numberof cytosines sequenced at that base. The probability was then corrected using the

NATURE CELL BIOLOGY

© 2013 Macmillan Publishers Limited. All rights reserved.

METHODS DOI: 10.1038/ncb2879

Benjamini–Hochberg (BH-) FDR function and the list of CpG sites was thresholdedat the 0.01 FDR level. See Supplementary Table 3.

A two-tailed Fisher exact test was used to identify CpGs that were differentiallymethylated. Only CpGs determined using the binomial distribution in at least onesample, with at least three reads in at least one condition and with at least one readin the other condition, were considered for testing. P-values were corrected usingthe BH-FDR function to control false positives at a rate of 5%. See SupplementaryTable 8.

Identification of DMRs. DMRs were calculated using a sliding window approach,window size 2 kb. Windows start at an individual CpG and would extend 2 kb,ending at the final CpG contained within the window. At each window a two-tailed G-test of independence was carried out on both pooled and individualreplicates. Total G-value was defined as the sum of the G-value for the individualreplicates. Owing to the additive nature of G-tests, we were also able to computea heterogeneous G-value (the difference between the total and pooled G-values).Each G-value was converted to a P-value using a chi-square distribution at highprecision and the Python arbitrary precision mathematics (mpmath) package; thisP-value represents the overall significance of the window taking into account thethree replicates, whereas the P-value calculated from the heterogeneous G-value isto identify regions where replicates are significantly different.

P-values from pooled and heterogeneous G-tests were corrected using theBH-FDR function and transformed for display on the UCSC Genome Browseras −10 log10(FDR). Transformed P-values were multiplied by −1 if the pooledpercentagemethylationwas lower in senescent samples than in proliferating samples(reflecting that hypomethylation is shown as a negative value). Difference P is atwo-tailed G-test of independence on pooled samples for 2 kb windows.

Windows within 4 kb which had FDR corrected P-values of less than 0.05were merged for both pooled and heterogeneous P-values and resulting regionssmaller than 5 kb were discarded. When comparing proliferating and senescentsamples, 46 regions (spanning 353,622 bp—approximately 0.01% of the genome)were identified under these criteria as having significant FDR-adjusted P-valuesfor heterogeneity, and these regions were removed from the proliferating versussenescence pooled DMR regions.

Methylation difference plots. Data bins were created for the integer values 0–100and initialized as empty lists. For each CpG site within the pooled data, themethylation percentages for proliferating and senescent samples was calculated,considering only CpGs with minimum coverage of 10 reads in at least one sampleand three reads in both samples. The methylation percentage of the proliferatingsample was truncated to an integer value and used to select an appropriate databin, into which the senescent sample methylation percentage was appended, andthe average of each bin was computed, giving the corresponding final methylationpercentage in senescent cells. Methylation difference was defined as the differencebetween starting and final average methylation percentages.

Smoothed methylation plots. The pooled whole-genome methylation data wereprocessed using the BSmooth algorithm from the bsseq (v0.8.0) package withinBioconductor as described in refs 36,70. A modified version of the bsseqplotSmoothData function was created to plot the smoothed data with individualCpGs shown (addPoints= True) but suppressing the vertical ablines.

Methylation versus expression plots. Affymetrix raw data files (CEL) for eachGeneChip were imported into R and analysed using the Bioconductor (http://www.bioconductor.org) packages. The GCRobustMulti-array Averagemethod wasused to background correct and normalize all samples. Each probe was mappedto an Ensembl gene identifier using the array’s NetAffx annotation (version 29),and the fold change and expression in proliferating were mapped to the Ensemblgene identifier. Probes that mapped to multiple distinct Ensembl genes werediscarded. Where multiple probes map to a single gene the geometric average of theexpression/fold change was calculated. Results were then plotted using the ggplot2package within R.

Correlation between replicates. Replicates were compared pairwise, and for eachCpG the methylation percentage for each replicate was calculated, for those CpGswith minimum coverages of 10 in one replicate and three in both replicates. ThePearson correlation coefficient was then calculated and results are presented inSupplementary Table 4.

Determination of overlaps. Overlaps were computed on a per base pair basisbetween two datasets (A and B). For every region within A the number of base pairsthat were occupied by a region within B was computed. A permutation test wascarried out to determine the background genomic average expected overlap. 1000sets of regions with properties (length distribution and chromosome distribution)equal to those of set B were generated. Randomly generated regions of B wereprevented from being generated within unsequenced regions of the genome (asdefined by UCSCmapping and sequencing track—gap). The overlap of A and B wasrepeated for each randomly generated set of B to determine the average expectedrandom overlap. P-values were estimated empirically from the observed overlaps ofthe randomly generated sets.

Identification of altered methylation associated with altered gene expression. Thiswas carried out as described in ref. 23. For this approach, methylation signatureswere created for each gene by interpolating the differential methylation scores overa fixed window relative to the gene’s TSS. A curve similarity metric, the discreteFréchet distance, was used to cluster genes together on the basis of the shape of thedifferential methylation data in the window. We then identified clusters of geneswith similar patterns that have coordinated differential expression. To generate agene list, we executed this procedure over many 5 kb windows around the TSS andselectively combined the results.

All three replicate pairs were pooled and cross-referenced with Ensembl to deter-mine the TSS. Genes containing no sites with a differential methylation level of atleast 0.2within thewindowwere removed.Genes forwhichmethylation could not beinterpolated owing to a low number of sites in the region were removed. Signatureswere clustered for 23 5 kb windows overlapping every 500 bp, covering the area from8 kb upstream of the TSS to 8 kb downstream. Clusters that were significantly up- ordownregulated when compared with the overall set of expression values were thenidentified (Kolmogorov–Smirnov test; FDR< 0.05 using BH). The Fréchet distancewas computed using a scaling factor between the x axis (bp) and y axis (differentialmethylation score) of 2,500 bp to one unit. A minimum cluster size of 10 and a min-imum cluster purity of 0.85 were used. Gaussian smoothing (σ = 30) was applied tothe signatures before clustering. A gene was included in the final list if at least two ofits replicates were present in a significant cluster for at least two of the 5 kb windows.

One primary way in which false positives could be introduced with this methodis for a cluster of genes to form at random whose expression values happen tobe statistically significant. As a control, we clustered the methylation curves andthen scrambled their expression values before determining significant clusters andmaking a gene list as above. For 1,000 sets of scrambled expression values, weerroneously returned, on average, less than one gene per experiment (0.178). Of allexperiments, 5.4%had one erroneous gene, 3.3%had two erroneous genes and 1.6%had three or more erroneous genes.

For the metagene analysis in Fig. 2 and Supplementary Table 11, the averagedifferential methylation score was computed across all replicates and all genesdownregulated in the final gene list.

External data. Late/early-replicating domains. We determined domains of replica-tion timing as in ref. 35 on the basis of the data from ref. 31. Percentage normalizedreplication timing data were obtained (personal communication, Scott Hansen),and then we identified regions with a late:early log2-ratio (with a pseudocount of 1added to both numerator and denominator of the ratio) of greater than or equal to1.5 for late-replicating regions and less than or equal to −1.5 for early-replicatingregions. Matching positions within 2 kb were merged and regions larger than100 kbwere selected as late/early-replicating domains (yielding 1,029 late-replicatingregions and 1,075 early-replicating domains).

cDMRs. Colon cancer DMRs were obtained from ref. 36 and converted to hg18using the UCSC liftOver tool for direct comparison with our data. This resulted ina total of 13,455 hypo- and 2,865 hypermethylated cDMRs. A total of 73 regionsfailed to completely map to the hg18 assembly, whereas 18 mapped to unfinishedor unassembled regions of the genome (that is chr6_random) and were discarded.Colon cancer DMRs were also obtained from ref. 35 (GSE48580). Briefly, domainsidentified in cancer cells as hyper/hypomethylated were downloaded (in hg18format) and regions of hyper/hypomethylation in normal cells were subtracted usingsubtractBed (bedtools) with a minimum overlap of 50%. Breast cancer bisulfitesequencing raw data were obtained from ref. 3 (GSE29127) and were processed asabove to generate DMRs.

Accession numbers. Primary accessions—Bisulfite sequencing of proliferating,senescent and SV40 bypass cells (GSE36640).

Referenced accessions—Gene expression array (GSE36616)) and lamin B1chromatin immunoprecipitation sequencing (GSE32399) in matched cells18,bisulfite sequencing raw data (GSE29127; ref. 3), cDMRs (GSE32399; ref. 35).

65. Pchelintsev, N. A. et al. the HIRA histone chaperone complex in the chromatinlandscape. Cell Rep. 3, 1012–1019 (2013).

66. Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J. & Toussaint, O. Protocols todetect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarkerof senescent cells in culture and in vivo. Nat. Protoc. 4, 1798–1806 (2009).

67. Harlow, E. & Lane, D. Antibodies: A Laboratory Manual (Cold Spring HarborLaboratory Press, 1988).

68. Langmead, B., Trapnell, C., Pop, M. & Salzberg, S. L. Ultrafast and memory-efficientalignment of short DNA sequences to the human genome. Genome Biol. 10,R25 (2009).

69. Krueger, F. & Andrews, S. R. Bismark: a flexible aligner and methylation caller forBisulfite-Seq applications. Bioinformatics 27, 1571–1572 (2011).

70. Hansen, K. D., Langmead, B. & Irizarry, R. A. BSmooth: from whole genomebisulfite sequencing reads to differentially methylated regions. Genome Biol. 13,R83 (2012).

NATURE CELL BIOLOGY

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

WWW.NATURE.COM/NATURECELLBIOLOGY 1

DOI: 10.1038/ncb2879

A! B!

Days!

Popu

latio

n do

ublin

gs!

20!

30!

40!

50!

60!

70!

80!

90!

100!

0! 50! 100! 150!

Supplementary Figure 1!

Prolif! Sen!

% S

A β-

gal +

ve c

ells!

Prolif! Sen!

% c

yclin

A +

ve c

ells!

Prolif! Sen!

C!

E! G!

% S

AHF

+ve

cells!

Prolif! Sen!

% C

ells

with

HIR

A/PM

L !

colo

caliz

atio

n!

Prolif! Sen!

I!

D! F!

Prolif! Sen!

Prol

if!

DAPI! Cyclin A!

Sen!

H!

DAPI! HIRA!PML!

Prol

if!Se

n!

0!

10!

20!

30!

40!

50!

0!

20!

40!

60!

80!

100!

0!

20!

40!

60!

80!

100!

0!

20!

40!

60!

80!

100!

Supplementary Figure 1 Confirmation of senescence in IMR-90 cells. (A) Growth curve of IMR-90 cells grown in 3% O2 shows proliferation ceased at population doubling (PD) 88. Scale bar = 30mm (B) Senescence-Associated β-galactosidase staining in proliferating (prolif), PD28 and senescent (sen), PD88. (C) Quantitation of senescence-associated β-galactosidase (SA β-gal) positive cells. (D) Immunofluorescence of proliferating and senescent cells with a marker of cell proliferation, cyclin A and 4’, 6-diamidino-2-phenylindole (DAPI). Scale bar = 5mm. (E) Quantitation of cyclin A positive cells. (F)

Staining of proliferating and senescent cells with DAPI shows senescent cells displaying senescence associated heterochromatin foci (SAHF). Scale bar = 5mm. (G) Quantitation of SAHF positive cells. (H) Immunofluorescence of PML and HIRA in proliferating and senescent cells shows co-localization of these 2 proteins, a known marker of senescence in the senescent population. (I) Quantitation of cells with HIRA and PML co-localization. In panels (C), (E), (G) and (I), data was obtained from at least 100 cells scored from a single sample, representative of at least 10 independent samples.

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

2 WWW.NATURE.COM/NATURECELLBIOLOGY

0809_P

A(3)1_

nuH_IM

R90_P

D28_r

1_2.CE

L

0809_P

A(3)2_

nuH_IM

R90_P

D28_r

2_2.CE

L

0809_P

A(3)3_

nuH_IM

R90_P

D28_r

3_2.CE

L

0809_P

A(3)4_

nuH_IM

R90_P

D28_r

4_2.CE

L

0809_P

A(3)5_

nuH_IM

R90_P

D28_r

5.CEL

0809_P

A(3)6_

nuH_IM

R90_P

D90_r

1.CEL

0809_P

A(3)7_

nuH_IM

R90_P

D90_r

2.CEL

0809_P

A(3)8_

nuH_IM

R90_P

D90_r

3.CEL

0809_P

A(3)9_

nuH_IM

R90_P

D90_r

4.CEL

0809_P

A(3)10

_nuH_

IMR90_

PD90_

r5.CEL

ABCF1 (200045_at)NFKB1 (209239_at)IL1RAP (210233_at)TNFAIP6 (206025_s_at)CDO1 (204154_at)C5 (205500_at)NMI (203964_at)AFAP1L2 (226829_at)NOD1 (224190_x_at)HDAC9 (205659_at)RIPK2 (209545_s_at)MGLL (225102_at)CXCR4 (217028_at)CXCL10 (204533_at)CHST2 (203921_at)CFH /// CFHR1 (215388_s_at)APOL3 (221087_s_at)SCG2 (204035_at)PTX3 (206157_at)IL10RB (209575_at)CXCL1 (204470_at)CCL26 (223710_at)AOX1 (205083_at)TACR1 (230908_at)IL8 (211506_s_at)GPR68 (229055_at)CXCL11 (211122_s_at)NFE2L1 (214179_s_at)TPST1 (204140_at)ANXA1 (201012_at)

−1 0 1Value

0

Color Keyand Histogram

Count

A! B!

C!

Supplementary Figure 2!

Gene set! No.genes!

NES!

FWER!p-

value!

1.  Cell cycle process! 181! -2.64! 0!

2. Cell cycle phase! 158! -2.60! 0!

3. Mitotic cell cycle! 140! -2.59! 0!

4. Chromosome! 115! -2.52! 0!

5. Cell cycle G0! 297! -2.49! 0!

6. M-phase! 106! -2.47! 0!

7. Chromosomal part! 89! -2.44! 0!

8. M-phase of mitotic cell cycle! 79! -2.41! 0!

9. Mitosis! 76! -2.40! 0!

10. Spindle! 39! -2.30! 0!

11. DNA replication! 96! -2.29! 0!

12. DNA metabolic process! 244! -2.27! 0!

Proliferating! Senescent!

0809_PA(3)1_nuH_IMR90_PD28_r1_2.CEL 0809_PA(3)2_nuH_IMR90_PD28_r2_2.CEL 0809_PA(3)3_nuH_IMR90_PD28_r3_2.CEL 0809_PA(3)4_nuH_IMR90_PD28_r4_2.CEL 0809_PA(3)5_nuH_IMR90_PD28_r5.CEL 0809_PA(3)6_nuH_IMR90_PD90_r1.CEL 0809_PA(3)7_nuH_IMR90_PD90_r2.CEL 0809_PA(3)8_nuH_IMR90_PD90_r3.CEL 0809_PA(3)9_nuH_IMR90_PD90_r4.CEL 0809_PA(3)10_nuH_IMR90_PD90_r5.CEL GNAI2 (201040_at)PCDHB3 (221410_x_at)RPPH1 (1556684_at)DLGAP4 (202571_s_at)GM2A (33646_g_at)TAGLN (1555724_s_at)−−− (235511_at)GPR108 (225058_at)CD44 (216056_at)C3orf10 (224575_at)SAMD8 (242062_at)NKIRAS2 (218240_at)ATPIF1 (218671_s_at)CRCP (203898_at)C9orf5 (223006_s_at)−−− (242752_at)TNFRSF10C (234644_x_at)−−− (214781_at)CHPF (202175_at)ATXN7L1 (214343_s_at)TMEM42 (226361_at)TAPBP (208829_at)ATP6V0D1 (212041_at)CTTN (214074_s_at)PLD3 (201050_at)ATP6V0C (36994_at)PEX19 (201706_s_at)ATL3 (223453_s_at)LOC285147 (236166_at)GPER (210640_s_at)DDX3X (1558120_at)FILIP1 (1570515_a_at)PDDC1 (227968_at)DGKE (207518_at)C5AR1 (220088_at)XIAP (206536_s_at)PBLD (219543_at)KRTAP4−12 (224269_at)PTDSS2 (221005_s_at)AGTRAP (225059_at)FREM3 (243337_at)FLJ32063 (235147_at)HIST1H2BJ (214502_at)VPS53 (227229_at)USP30 (223602_at)TMC7 (220021_at)WBP2 (209117_at)COL10A1 (217428_s_at)−−− (242253_at)BCL11A (219498_s_at)ELMOD2 (1553928_at)CLCN7 (221961_at)IPW (221974_at)C13orf1 (230151_at)ZNF432 (219848_s_at)GREM2 (240509_s_at)MAP2K3 (215498_s_at)LOC729580 (225860_at)LOC643650 (1563742_at)GPX1 (200736_s_at)WNT5B (223537_s_at)DNAJC16 (212908_at)LDLR (202067_s_at)CD99L2 (233844_at)SGTB (232084_at)IRGQ (1569310_at)−−− (236719_at)−−− (222312_s_at)ZNF264 (205917_at)−−− (236089_at)RIT1 (236224_at)LOC284440 (1555363_s_at)−−− (239333_x_at)MIPOL1 (244246_at)−−− (230321_at)STS (203768_s_at)POLR2L (211730_s_at)SEC23B (210293_s_at)C7 (235979_at)PLGLB2 (230120_s_at)IPP (241393_at)ZNF207 (1556035_s_at)C9orf117 (1557867_s_at)PEX14 (33760_at)ANTXR1 (220093_at)C5orf24 (224875_at)DOPEY1 (40612_at)WWOX (219077_s_at)ZEB1 (210875_s_at)−−− (212867_at)DNAJB14 (222850_s_at)−−− (235505_s_at)TRPS1 (224218_s_at)ARHGAP5 (233849_s_at)TSPYL1 (1560647_at)−−− (239847_at)−−− (1556645_s_at)CXADR (203917_at)PAR5 (214834_at)TSPYL1 (1560648_s_at)KIAA1704 (226429_at)PMP22 (210139_s_at)PARD3B (1553188_s_at)TTLL1 (205652_s_at)FBXL18 (227500_at)NDRG3 (224368_s_at)CTA−221G9.4 (225525_at)CYLD (221905_at)BST2 (201641_at)GBP4 (235574_at)LOC338651 (1562681_at)AP3S2 (213215_at)−−− (1554751_at)ADAM12 (202952_s_at)FLJ42627 (221944_at)−−− (1560048_at)−−− (244201_at)−−− (227749_at)ABAT (209459_s_at)IFIT2 (217502_at)RSAD2 (242625_at)−−− (242365_at)LOC283904 (243059_at)EDN1 (218995_s_at)STX4 (229395_at)SLC39A13 (225277_at)−−− (1556996_at)C14orf182 (237460_x_at)ZNF271 (236231_at)−−− (1558401_at)CCL26 (223710_at)TST (209605_at)RNF187 (230662_at)ZNF641 (235179_at)−−− (235843_at)NIPA1 (1552696_at)C5orf24 (1553107_s_at)FDX1L (226451_at)PDPK1 (204524_at)FAM55C (243011_at)MAN1B1 (218636_s_at)C3orf18 (219114_at)ELAC2 (201766_at)CAB39L (221003_s_at)GRB2 (215075_s_at)PPPDE2 (212527_at)ATG9A (202492_at)C1orf91 (223676_at)SLC46A3 (214719_at)ZNF229 (1562789_at)MIF4GD (231727_s_at)PRR5 (47069_at)SLC6A8 (210854_x_at)SLC6A8 (202219_at)TMEM115 (216267_s_at)SLC44A2 (225175_s_at)APBA2 (209870_s_at)HEG1 (212822_at)CTF1 (206813_at)LPHN3 (242186_x_at)LOC100130740 (239791_at)−−− (236764_at)ZFAND5 (228317_at)MAPK8IP3 (230162_s_at)−−− (235190_at)VDR (213692_s_at)−−− (237348_at)−−− (228632_at)−−− (1558048_x_at)FAM98A (241832_at)MDH2 (213333_at)ZDHHC21 (233216_at)SYTL5 (242093_at)SEL1L (202063_s_at)SLC35E1 (222263_at)FHL1 (214505_s_at)FAM84A (234331_s_at)INMT (224061_at)ITGA11 (1554819_a_at)INTS10 (229633_at)−−− (1556636_at)FGFR2 (208229_at)C14orf37 (1557176_a_at)ULBP1 (221323_at)ANKRD13B (227720_at)ZKSCAN1 (214900_at)−−− (229979_x_at)ERBB2 (234354_x_at)FMNL3 (227844_at)MST150 (223276_at)STAT2 (205170_at)GALNT5 (237183_at)LUC7L (1557066_at)FHL1 (201539_s_at)EFEMP1 (228421_s_at)M6PRBP1 (202122_s_at)FHL1 (210298_x_at)TRIM38 (203610_s_at)THBS1 (215775_at)LRSAM1 (235449_at)PCSK6 (211262_at)APLP2 (208702_x_at)TMEM127 (222887_s_at)−−− (237171_at)RAB6B (221792_at)EML2 (204398_s_at)KLHDC8B (225755_at)LOC375010 (1558982_at)EXT2 (202013_s_at)IL7R (205798_at)JHDM1D (225142_at)EPHB2 (211165_x_at)PERLD1 (221811_at)−−− (236483_at)ZSWIM5 (232336_at)DIXDC1 (214724_at)C3orf38 (1569128_at)−−− (232544_at)STRADA (221554_at)COL10A1 (205941_s_at)CLN8 (222874_s_at)FAM124A (230519_at)−−− (227995_at)−−− (230014_at)SLC5A3 (1553313_s_at)−−− (1570301_at)SIAE (223744_s_at)TFE3 (1567704_at)FLJ42627 (232050_at)MDM2 (244616_x_at)GREM2 (220794_at)STK10 (228394_at)CDC34 (212540_at)SENP5 (213184_at)MIPOL1 (1552572_a_at)PCYT1A (204210_s_at)SAA1 /// SAA2 (208607_s_at)SAPS2 (202792_s_at)ERO1LB (231944_at)GPX3 (214091_s_at)−−− (228371_s_at)MBTPS1 (217543_s_at)MRVI1 (224550_s_at)SHC4 (235238_at)ITPRIPL2 (227956_at)UHRF1BP1 (233245_at)FAM18B2 (1552377_s_at)PSMC2 (238020_at)MTSS1 (210359_at)−−− (1561135_at)RNFT1 (221194_s_at)SLC2A6 (220091_at)RNF144B (239012_at)HSPB3 (206375_s_at)CCRL1 (220351_at)PI4K2A (209345_s_at)ERGIC1 (224024_at)EIF4E3 (238461_at)ZMYM6 (227594_at)LOC375295 (228564_at)SDCCAG8 (1553034_at)CLPTM1L (229416_at)DSCR3 (217309_s_at)ENTPD4 (1555358_a_at)SOD3 (205236_x_at)HIPK2 (225115_at)DAGLB (225832_s_at)ANK1 (208353_x_at)TMED4 (224676_at)PTPRG (244574_at)CST4 (206994_at)−−− (243065_at)−−− (229635_at)LOC100130955 (210795_s_at)DYNC1LI2 (203590_at)NCRNA00084 (238320_at)NCRNA00084 (227062_at)FOXG1 (206018_at)FN1 (214702_at)SYNGR1 (213854_at)MRS2 (227789_at)−−− (235830_at)GABRE (204537_s_at)KCNAB1 (210471_s_at)MDM2 (205385_at)MYH11 (207961_x_at)ABCA3 (204343_at)NEU1 (208926_at)GOSR2 (239159_at)LOC100131781 (240320_at)B3GNT2 (219326_s_at)EPHX1 (202017_at)DAGLB (225833_at)MMP19 (204574_s_at)LRRC66 (1568634_a_at)PLEKHA1 (219024_at)KRT15 (204734_at)PDK2 (213724_s_at)LOC401577 (239247_at)C2orf63 (228316_at)KCP (1556956_at)SEMA3E (206941_x_at)FICD (219910_at)CCNG2 (228081_at)LAMP1 (201551_s_at)LOC338799 (1556042_s_at)CYBA (203028_s_at)CD69 (209795_at)LOC440416 (229669_at)BCL2L2 (1555140_a_at)LDLR (202068_s_at)PNPO (222653_at)TPM2 (227397_at)TSPAN31 (203226_s_at)C15orf17 (224798_s_at)MAP1LC3A (227219_x_at)SEMA4F (211157_at)FBRSL1 (225704_at)HINT3 (226537_at)−−− (230099_at)PRR4 (204919_at)MAPRE3 (203841_x_at)LOC113230 (1558412_at)RCAN1 (215253_s_at)AK1 (202588_at)ZG16B (228058_at)SLC25A45 (1563498_s_at)FADS3 (216080_s_at)−−− (231643_s_at)IGFBP7 (213910_at)ZNF846 (1564331_at)TMEM176B (220532_s_at)SELM (226051_at)−−− (214807_at)TCEA2 (241428_x_at)C3orf10 (224023_s_at)NAPA (206491_s_at)RAB3B (205924_at)−−− (231819_at)GM2A (209727_at)FBXO28 (1555972_s_at)TGOLN2 (203834_s_at)HEATR7A (232498_at)GOLGA2 (35436_at)NKAP (228493_at)VAMP3 (201337_s_at)TFAP2C (205287_s_at)TNFRSF21 (214581_x_at)ATP6V0A1 (205095_s_at)DYNC1LI2 (213162_at)SLC48A1 (218417_s_at)CLN8 (223912_s_at)GALNT10 (230906_at)PHF23 (1555789_s_at)UBE2H (227950_at)ATP6V1F (201527_at)PSG3 (211741_x_at)C2orf24 (207511_s_at)SPRY4 (220983_s_at)ITPRIPL2 (227514_at)LRP12 (219631_at)PVR (32699_s_at)SLC39A9 (217859_s_at)PCNX (239100_x_at)C13orf31 (1553142_at)PDE1C (239218_at)DAG1 (212128_s_at)HRASLS (219983_at)−−− (215507_x_at)BCL2L1 (215037_s_at)GM2A (215891_s_at)COL4A3BP (223465_at)GCA (203765_at)SLC39A8 (219869_s_at)BCL2L1 (206665_s_at)GCLM (203925_at)MAPRE3 (229682_at)TIMP2 (203167_at)−−− (229733_s_at)APLP2 (208701_at)GSN (227957_at)ETFB (202942_at)CLTB (206284_x_at)SLC12A4 (209400_at)−−− (232653_at)ZBTB4 (227047_x_at)PHKG1 (234729_at)SIGMAR1 (214484_s_at)SQLE (213577_at)FTL (213187_x_at)MGLL (211026_s_at)MGC23284 (1556154_a_at)−−− (1566967_at)HM13 (224615_x_at)VPS53 (235710_at)DPM3 (219373_at)ABHD12 (228123_s_at)RHBDF1 (218686_s_at)PKIG (202732_at)SSR4 (201004_at)TMEM208 (221597_s_at)−−− (233668_at)ADRA2C (206128_at)SHC1 (201469_s_at)GFPT1 (202721_s_at)SCN3A (232512_at)MAPRE2 (202501_at)FLJ43663 (228702_at)BCR /// FLJ42953 /// LOC100133163 /// LOC728468 (226602_s_at)GRN (216041_x_at)TYRP1 (205694_at)TMEM120A (223482_at)CLTB (205172_x_at)APBA1 (206679_at)HMGCL (202772_at)−−− (233020_at)RORA (240951_at)MIA3 (1569057_s_at)MPP5 (235864_at)CFLAR (211316_x_at)MAPRE3 (203842_s_at)SRPRB (222532_at)C5orf45 (220341_s_at)MITF (207233_s_at)GAS6 /// LOC100133684 (202177_at)SENP5 (222110_at)CST3 (201360_at)LDB1 (35160_at)LDB1 (203451_at)OAS2 (206553_at)MGAT5 (206720_at)DDAH1 (229456_s_at)AP1S1 (209635_at)RABAC1 (203136_at)TXNIP (201008_s_at)MEGF9 (212831_at)BCAP31 (200837_at)CENPT (218148_at)−−− (235640_at)EXOC2 (226270_at)PAPPA (1559400_s_at)IVD (225311_at)−−− (228586_at)PEA15 (200787_s_at)SAMD4A (215120_s_at)MALAT1 (227510_x_at)NUDT16 (235002_at)IPP (219843_at)STK38 (1553117_a_at)CRYGS (223644_s_at)CCDC102B (220301_at)FLJ12993 (229623_at)PAFAH2 (205232_s_at)LOC642852 (243656_at)−−− (236713_at)RXRB (215099_s_at)ZRANB2 (241345_at)C1orf104 (1552862_at)STIM1 (202764_at)−−− (1564129_a_at)RXRB (215098_at)−−− (239814_at)CCNL2 (221427_s_at)ARHGAP23 (226638_at)MCFD2 (212246_at)LMF1 (219136_s_at)−−− (244069_at)RHOJ (1555234_a_at)APC (216933_x_at)ERGIC3 (216032_s_at)C19orf6 (230089_s_at)SAR1A (210790_s_at)OTUB2 (222878_s_at)NDFIP2 (230190_at)PLEKHB2 (201411_s_at)C19orf6 (213985_s_at)MPP2 (207984_s_at)PVR (214444_s_at)ETV5 (203349_s_at)ATF3 (202672_s_at)DRAM (218627_at)CAV2 (203323_at)FNDC3B (225032_at)B3GNT2 (222870_s_at)RHOJ (243481_at)NPC2 (200701_at)ST7L (236123_at)DAB2 (210757_x_at)TAX1BP1 (200977_s_at)GPR107 (211979_at)LPIN1 (212276_at)CREG1 (201200_at)PTPRK (203038_at)ARHGAP24 (223422_s_at)CTSO (203758_at)DNAJB12 (202866_at)GBA /// GBAP (209093_s_at)ARSD (223695_s_at)C12orf5 (219099_at)APC (203526_s_at)−−− (226034_at)GSTM3 (235867_at)SLC35B3 (222691_at)ATP6V1C1 (202874_s_at)STAT3 (225289_at)CXorf39 (225216_at)OCIAD1 (223011_s_at)EML1 (204797_s_at)TMCO1 (210768_x_at)VEPH1 (229759_s_at)GALNT10 (207357_s_at)SLC36A1 (213119_at)ITFG1 (221449_s_at)ATP6V1G1 (208737_at)ME1 (204059_s_at)MCTP2 (220603_s_at)SQLE (209218_at)CRYAB (209283_at)LMLN (238037_at)MEST (202016_at)CROT (204573_at)NUFIP2 (224938_at)FBXL20 (235089_at)ATP11A (213582_at)SLFN12 (219885_at)TMEM80 (65630_at)DENND4A (1554352_s_at)−−− (230449_x_at)−−− (212812_at)SAMHD1 (204502_at)VAMP3 (201336_at)STAT1 (209969_s_at)SH3TC2 (240966_at)SLC35A3 (206770_s_at)−−− (1569362_at)SH3KBP1 (223082_at)NDRG3 (221082_s_at)MAN1A2 (217920_at)TMEM97 (214283_at)PIGP (221689_s_at)−−− (231890_at)−−− (235058_at)ZDHHC21 (241946_at)−−− (228341_at)SSR1 (225435_at)PHKB (238601_at)PIK3R1 (212239_at)DNAJB14 (219237_s_at)NPR2 (204310_s_at)TMEM185A (231326_s_at)UBXN8 (215983_s_at)KIAA1468 (225508_at)SPR (203458_at)TMEM38B (222736_s_at)OSTM1 (218196_at)NT5E (1553994_at)TM7SF3 (222477_s_at)RPL37 (224763_at)TBXAS1 (236345_at)ATP7A (205198_s_at)AGPAT3 (223183_at)C22orf25 (235396_at)AOX1 (205083_at)RPS27L (238935_at)LIMK2 (202193_at)CD59 (228748_at)SCN9A (206950_at)KRAS (204010_s_at)FBXO9 (1559094_at)CHIC1 (228345_at)PRDM1 (228964_at)COL13A1 (211343_s_at)REEP5 (208873_s_at)RAB22A (213405_at)DNMBP (212838_at)CGRRF1 (204605_at)KCMF1 (240430_at)DOLK (204488_at)EME2 (1569868_s_at)FAS (204781_s_at)C18orf8 (221190_s_at)FXC1 (222481_at)LOC647979 (224597_at)BBS7 (235007_at)XIAP (225859_at)SDF4 (224472_x_at)SGMS1 (212989_at)ZNF235 (210595_at)KLHL28 (228328_at)ATP2C1 (209935_at)SOS1 (212780_at)BLZF1 (32088_at)−−− (229544_at)ZMPSTE24 (202939_at)−−− (235805_at)hCG_1806964 (232298_at)FBXO28 (202271_at)STS (203769_s_at)APC (203525_s_at)MGST1 (224918_x_at)−−− (227853_at)TMEM206 (222752_s_at)TNFRSF10C (211163_s_at)BRWD1 (231860_at)CAP2 (212554_at)−−− (230178_s_at)TRADD (1729_at)PTPRM (1555578_at)LOC152225 (1562048_at)NUAK1 (204589_at)IL7R (226218_at)ATP11A (230875_s_at)CAMK1D (235626_at)LOC727893 /// PDE4DIP (212390_at)NUDT16L1 (224477_s_at)DHRS7B (220690_s_at)C16orf52 (227351_at)PCNX (213159_at)TPP1 (214195_at)TMTC3 (226604_at)C1orf122 (225480_at)PIGG (218652_s_at)SIDT2 (218765_at)DDR1 (207169_x_at)ZBTB1 (205092_x_at)C20orf108 (224690_at)−−− (240721_at)SNX1 (213364_s_at)ALKBH6 (225969_at)COX4I1 (213758_at)BBS12 (229603_at)ANO10 (218910_at)KATNAL1 (227713_at)LOC729082 (225225_at)C1orf103 (220235_s_at)UNKL (229908_s_at)MAP1LC3B (208785_s_at)RTN2 (34408_at)CDKN2A (207039_at)CLCN3 (201734_at)−−− (238477_at)LYRM5 (225469_at)RPL7AP45 (236453_at)TMEM131 (212507_at)RNF170 (220985_s_at)NIPAL2 (227001_at)WDR47 (203855_at)TM7SF3 (217974_at)DDX58 (222793_at)SLC17A5 (223441_at)C1orf85 (1558692_at)CIAO1 (217501_at)CLIP1 (201975_at)GOPC (225023_at)BLOC1S2 (225049_at)CSGALNACT2 (222235_s_at)UQCRB (244293_at)APBA1 (228101_at)TBXA2R (336_at)−−− (241371_at)LPXN (216250_s_at)BTG2 (201236_s_at)CALD1 (235834_at)SEPW1 (1555851_s_at)SERINC2 (224762_at)DHCR7 (201791_s_at)GABARAPL2 (209046_s_at)NDRG3 (217286_s_at)STK38 (202951_at)TOM1L2 (226198_at)C17orf91 (214696_at)SYNGR2 (201079_at)GSTM3 (202554_s_at)C1orf52 (228135_at)−−− (242826_at)LMBRD1 (218191_s_at)CLPTM1L (226935_s_at)FGL2 (204834_at)KCNJ2 (206765_at)−−− (1557667_at)TAPT1 (238798_at)LEPR (211354_s_at)NLRX1 (219680_at)−−− (1565601_at)LOC643837 (227201_at)NAT15 (45526_g_at)BRWD1 (231960_at)SLC22A5 (205074_at)PACS2 (1555824_a_at)UBE2F (231948_s_at)NOL3 (1558738_at)FAM46A (221766_s_at)SCO2 (205241_at)IQSEC1 (203907_s_at)ENGASE (65635_at)AMN1 (226258_at)MBD5 (227839_at)−−− (222947_at)LOC387647 (230737_s_at)−−− (230968_at)GADD45B (207574_s_at)−−− (231137_at)C15orf37 (1556588_at)PTPMT1 (225901_at)PDE1C (216869_at)DIRC2 (226026_at)LYPLAL1 (230174_at)CHST3 (209834_at)−−− (228465_at)−−− (235685_at)FNDC3B (229865_at)XPNPEP1 (217380_s_at)IFIT3 (229450_at)ENGASE (220349_s_at)KPNA1 (202057_at)SPTAN1 (215235_at)LRP8 (205282_at)RNF181 (229932_at)MFSD11 (223242_s_at)RNF24 (204669_s_at)C9orf5 (223008_s_at)−−− (231097_at)GABBR2 (217077_s_at)C1orf2 (203550_s_at)C8orf34 (231380_at)SYNJ1 (212990_at)UBR3 (234982_at)CDKN2A (209644_x_at)MRS2 (218536_at)NECAP1 (209300_s_at)MAP7 (202890_at)−−− (238733_at)TPM1 (206117_at)APBB2 (212970_at)NR3C2 (205259_at)H2AFJ (220936_s_at)−−− (238963_at)ANKRD60 (230683_at)KIRREL3 (240402_at)DCUN1D3 (239648_at)RUNDC3B (241703_at)CYP2U1 (226393_at)MYO5A (204527_at)ATP7A /// LOC644732 (205197_s_at)PLA2G16 (235110_at)NCOA3 (209060_x_at)PIK3R2 (229392_s_at)NHEDC2 (229491_at)AOX1 (205082_s_at)PI4KA /// PI4KAP1 /// PI4KAP2 (213408_s_at)IFFO1 (209721_s_at)OSR2 (213568_at)CHST7 (206756_at)TTC13 (219481_at)C15orf52 (227272_at)−−− (244853_at)TMOD2 (226186_at)−−− (1559776_at)FDFT1 (208647_at)−−− (226594_at)ABHD12 (228124_at)CMTM4 (224998_at)CCPG1 (214151_s_at)CYP2U1 (226402_at)RGNEF (232994_s_at)TRAK2 (202125_s_at)SPG7 (214494_s_at)UACA (223279_s_at)GADD45B (213560_at)C1orf104 (230256_at)KIF9 (231319_x_at)GPR107 (211977_at)C15orf57 (225397_at)PLXNA1 (221537_at)PORCN (219483_s_at)RTN1 (210222_s_at)C1orf53 (1558508_a_at)HBEGF (203821_at)SLC41A2 (235299_at)TRIM35 (227102_at)GTDC1 (219770_at)−−− (237571_at)−−− (238684_at)EXOG (205521_at)SRI (208920_at)LOC100272217 (243785_at)CREBL2 (201990_s_at)−−− (239896_at)MFSD5 (212861_at)−−− (235529_x_at)CSF1 (207082_at)−−− (230657_at)SSH2 (226080_at)−−− (244241_x_at)BBX (226331_at)−−− (237175_at)NEDD4 (213012_at)HCFC2 (235264_at)KCTD13 (45653_at)SYTL3 (238423_at)ATP6V1H (221504_s_at)GFRA1 (230163_at)EIF5A2 (235296_at)EPB41L1 (212336_at)LAP3 (217933_s_at)RBKS (219222_at)RNF135 (223592_s_at)RC3H2 (220202_s_at)−−− (239951_at)CD55 (201926_s_at)GGCX (205351_at)SLC25A30 (226782_at)SIRT4 (222248_s_at)−−− (241310_at)CTNS (204925_at)BCL6 (203140_at)ERP44 (208958_at)C1orf71 (225550_at)WDR66 (230193_at)UBL3 (201534_s_at)−−− (235381_at)GTF2H5 (1558934_a_at)RC3H2 (238421_at)−−− (230834_at)RNFT1 (227268_at)PNPLA8 (223982_s_at)EIF4G3 (201936_s_at)NPR2 (214066_x_at)IRGQ (242183_at)LMLN (229611_at)−−− (227333_at)KLHL29 (229310_at)−−− (206110_at)GCC2 (202832_at)CASP12 (1564736_a_at)−−− (236380_at)−−− (235293_at)MFAP3L (210843_s_at)SAMD12 (238673_at)RSAD2 (213797_at)IFI44 (214453_s_at)CMPK2 (226702_at)−−− (239262_at)C17orf48 (223401_at)SNX3 (213545_x_at)RNF19B (213038_at)RARRES3 (204070_at)CXCL11 (211122_s_at)LPAR2 (206723_s_at)SPRY2 (204011_at)KLHL18 (212882_at)PRLR (227629_at)SNAPC5 (213203_at)UBE2Q1 (217978_s_at)KIAA1529 (229628_s_at)BEX1 (218332_at)ABHD15 (226796_at)APBB2 (213419_at)OPTN (202073_at)MKNK2 (218205_s_at)VTI1B (225926_at)SEPT8 (208999_at)DSCR3 (203635_at)−−− (233506_at)GPR37 (209631_s_at)SARM1 (213257_at)PRICKLE1 (230708_at)EPHX4 (239579_at)BTN3A2 /// BTN3A3 (204820_s_at)KIAA1219 (221736_at)−−− (243976_at)GALNTL2 (239461_at)CREBL2 (201989_s_at)SNX29 (225624_at)GABBR2 (209991_x_at)PRKAA1 (225985_at)−−− (233233_at)EMP1 (213895_at)FLJ90757 (1566557_at)EML1 (204796_at)FLJ90757 (1566558_x_at)VDR (204255_s_at)PRKAA2 (238441_at)LOC401074 (1559826_a_at)CCDC93 (209689_at)MMAA (242750_at)C10orf35 (226313_at)SVEP1 (1566722_a_at)−−− (1557302_at)ASPH (242037_at)MYH11 (201497_x_at)PPP1R1C (1555462_at)SP100 (210985_s_at)AKR1B10 (206561_s_at)GNB5 (204000_at)RAB4B (233385_x_at)−−− (228944_at)−−− (235964_x_at)KIAA0141 (201978_s_at)UBE2F (225783_at)GPRASP2 (228027_at)TRAF3IP2 (202987_at)DNAH5 (232381_s_at)LOC100129250 (221979_at)−−− (228548_at)SLC20A2 (202744_at)SLC6A15 (206376_at)HHAT (219687_at)−−− (236097_at)ALDH2 (201425_at)C5orf41 (1554229_at)CHRNA1 (206633_at)MBTPS1 (201620_at)TRPC6 (206528_at)PSEN1 (226577_at)TMEM136 (238497_at)TRIM4 (223384_s_at)C4orf22 (231565_at)IFI44 (214059_at)NSBP1 (221606_s_at)NFE2L3 (204702_s_at)CYLD (213295_at)−−− (220915_s_at)PDIA3 (229453_at)GATAD1 (213018_at)−−− (214202_at)HHEX (204689_at)HSD17B6 (205700_at)SLC2A13 (227176_at)MX1 (202086_at)PHTF1 (235844_at)DDX60 (218986_s_at)TMEM39A (218615_s_at)TDRKH (223530_at)LOC100129195 (236777_at)SEMA3C (203788_s_at)−−− (238038_at)FYN (216033_s_at)−−− (217584_at)SEC61A2 (228747_at)ARHGAP26 (226576_at)ANAPC7 (225521_at)TIGD6 (220986_s_at)C1QTNF3 (209425_at)GSN (227958_s_at)OAS1 (202869_at)MOSC2 (227417_at)−−− (226374_at)−−− (1560286_s_at)PARP14 (232610_at)DACT1 (219179_at)KCTD18 (226493_at)SFRS12IP1 (227288_at)TAX1BP1 (213786_at)−−− (213429_at)−−− (229705_at)−−− (234431_at)AMPD3 (207992_s_at)KLHL20 (204176_at)ERAP1 (214012_at)EFEMP1 (201843_s_at)HEATR5A (226510_at)−−− (235889_at)−−− (231215_at)−−− (237169_at)ZXDB (228005_at)SCRN3 (219234_x_at)DNAJC21 (230893_at)ZNF365 (206448_at)ARHGAP5 (235635_at)LMF1 (219135_s_at)−−− (232130_at)ZNF271 (238007_at)NR1D1 /// THRA (204760_s_at)−−− (237168_at)NMNAT1 (229852_at)PDE11A (221110_x_at)BBS1 (218471_s_at)FYN (210105_s_at)−−− (1558208_at)BMPR1B (229975_at)TMEM108 (223524_s_at)TRAPPC2L (238628_s_at)MTM1 (36920_at)−−− (1555900_at)FGF1 (205117_at)FOXC1 (1553613_s_at)TOPORS (1564403_at)HDAC9 (205659_at)MAP6 (235672_at)EBF1 (229487_at)KCNU1 (237273_at)ZNF441 (1553193_at)−−− (227306_at)SLC25A21 (220474_at)LOC161527 /// PML (211012_s_at)KIAA1908 (1561666_a_at)NCAPH2 (40640_at)−−− (241011_at)FOXH1 (231407_s_at)ODZ4 (213273_at)FLJ43390 /// LOC100128793 (231186_at)C14orf28 (235369_at)TRAF4 (235688_s_at)FMO5 (1569688_at)−−− (241773_at)−−− (31799_at)−−− (225906_at)ACAP2 (1552472_a_at)GPR160 (223423_at)ACAA1 (202025_x_at)PLK3 (215462_at)KLRD1 (207795_s_at)−−− (243742_at)−−− (240357_at)NIPA1 (225752_at)ANAPC10 /// ANAPC10P (241959_at)MFSD8 (228282_at)LOC283868 (1564683_at)CYS1 (228739_at)DNAJC3 (208499_s_at)−−− (240169_at)−−− (235351_at)C1orf51 (227285_at)IL1RAPL1 (222963_s_at)SLC2A13 (1552694_at)SEC63 (235395_at)ATP13A1 (218052_s_at)ROBO2 (226709_at)C1orf85 (225401_at)LOC100129701 (239029_at)−−− (232257_s_at)EIF4EBP2 (208769_at)LOC344887 (241418_at)EZH1 (239197_s_at)CDYL2 (1553647_at)LOC100128309 (232300_at)MRS2 (228542_at)PRKRIP1 (218378_s_at)GAS2L1 (209729_at)ZNF2 (223792_at)C16orf46 (230281_at)PPAP2A (209147_s_at)ACTC1 (205132_at)FAM129C (230983_at)MYO5A (241966_at)RNF135 (223591_at)ZNF79 (214138_at)SNAPC5 (1554093_a_at)−−− (236515_at)HRSP12 (203790_s_at)EPHA4 (229374_at)NADK (208919_s_at)TMEM50A (222401_s_at)FGF2 (204421_s_at)DUSP10 (221563_at)SLC41A1 (225570_at)KIAA1033 (212794_s_at)LMBRD2 (232893_at)NIPAL2 (220128_s_at)PDCD1LG2 (224399_at)CDH6 (205533_s_at)CAT (201432_at)ARHGAP26 (205068_s_at)ETHE1 (204034_at)ENC1 (201341_at)ANXA1 (201012_at)LARP6 (218651_s_at)SLC25A4 (202825_at)DDX10 (204977_at)ZNF622 (225152_at)MSX2 (205555_s_at)−−− (231383_at)−−− (239437_at)−−− (243724_at)LOC100134722 (220692_at)TBX19 (206838_at)FAM124A (241829_at)SPATA2L (214965_at)CST2 (208555_x_at)SLC25A15 (218653_at)LOC100129461 (1556555_at)−−− (228914_at)ETV7 (224225_s_at)−−− (239488_at)FLJ35379 (239553_at)CBX4 (227558_at)NPLOC4 (217796_s_at)NPTXR (213040_s_at)DDX60L (228152_s_at)PLCH1 (214745_at)IFIT1 (203153_at)TMEM173 (224916_at)RER1 (213296_at)PMAIP1 (204285_s_at)HERC3 (206183_s_at)UHRF1BP1L (213118_at)UBE2D4 (218837_s_at)C10orf118 (219844_at)KCNAB1 (210078_s_at)ZBTB20 (205383_s_at)GPR115 (237690_at)−−− (1561595_x_at)FZD8 (227405_s_at)LOC728411 (1556742_at)C7orf41 (226018_at)FBXL20 (232412_at)−−− (232875_at)RBMS2 (225776_at)ACOX1 (227962_at)FAM55C (235030_at)SOX6 (227497_at)TNFRSF10C (206222_at)ARHGAP18 (225166_at)C17orf63 (218464_s_at)PTPRA (213799_s_at)MAPK8IP3 (213178_s_at)LENG8 (224673_at)HISPPD2A (204578_at)−−− (229654_at)DGKQ (226605_at)BTRC (204901_at)MCOLN1 (219952_s_at)PDZK1 (205380_at)CDK6 (243000_at)LOC729082 (225332_at)TMEM8 (221882_s_at)ATP6V0A1 (212383_at)MDM2 (229711_s_at)SNRPN /// SNURF (201522_x_at)NOG (231798_at)EDIL3 (1558643_s_at)TXNIP (201009_s_at)NEGR1 (1553194_at)C12orf68 (229626_at)BTBD9 (235248_at)−−− (226252_at)MORN4 (236813_at)NFAT5 (208003_s_at)PDE5A (1562227_at)OPN3 (224392_s_at)TUBA4A (212242_at)PSTPIP2 (219938_s_at)TPST1 (204140_at)LDLRAP1 (57082_at)MINK1 (214246_x_at)−−− (235571_at)MDM2 (217542_at)LIPH (235871_at)MALAT1 (224559_at)PRKCE (206248_at)NUFIP2 (224939_at)MFGE8 (210605_s_at)NCRNA00084 (214657_s_at)NCRNA00084 (224566_at)HEXA (201765_s_at)ERAP2 (235104_at)NCRNA00084 (234989_at)TMEM30A (232591_s_at)HGSNAT (1557064_s_at)EDEM2 (228016_s_at)−−− (242629_at)TOR1AIP2 (235453_at)CXXC5 (224516_s_at)EHF (219850_s_at)ANK1 (205389_s_at)−−− (220489_s_at)MANEAL (226132_s_at)GSTM2 (204418_x_at)GOLGB1 (201057_s_at)NAV1 (227584_at)ATP9A (212062_at)MEGF9 (212830_at)APOL6 (1557116_at)PION (222150_s_at)ENO3 (204483_at)−−− (235015_at)PCMTD1 (235507_at)C1S (1555229_a_at)KLHL24 (221986_s_at)YPEL5 (222408_s_at)−−− (213158_at)SEC63 (229969_at)C19orf66 (53720_at)APOL3 (221087_s_at)MAML3 (242794_at)USP9X (229573_at)PARP14 (224701_at)MAFG (204970_s_at)ZNF284 (239462_at)RIT1 (209882_at)−−− (1557275_a_at)C12orf73 (226943_at)−−− (1557522_x_at)GLRX (206662_at)TIMP3 (201150_s_at)CNIH3 (214841_at)ERMP1 (222603_at)TRIM13 (230192_at)−−− (222033_s_at)PAQR7 (242123_at)CYB5D2 (225804_at)−−− (1570575_at)PERP (236009_at)C20orf194 (226607_at)TM2D2 (224413_s_at)RHOJ (235489_at)TP53INP1 (225912_at)PTPRM (203329_at)PTPRM (1555579_s_at)SHC1 (214853_s_at)MARCH9 (230001_at)SYNPO2 (227662_at)GALNT5 (229555_at)FAM117B (1553220_at)PGM5 (226303_at)−−− (242005_at)RNF152 (1553721_at)ISCU (209075_s_at)ATCAY (227365_at)WRB (202749_at)HIST1H2BC (214455_at)HIST1H2BC (236193_at)LOC399959 (236640_at)PITPNM3 (230076_at)KRTAP1−5 (233533_at)UBR3 (244121_at)KIAA1632 (227638_at)CCPG1 (214152_at)C5orf53 (226977_at)ULBP2 (238542_at)SAMD9L (230036_at)GLS (203159_at)POMGNT1 (217944_at)LGMN (201212_at)KLC1 (212877_at)CST1 (206224_at)SPRY4 (221489_s_at)TGFB2 (209908_s_at)DAGLB (226640_at)FAS (204780_s_at)CHCHD7 (218642_s_at)CCDC81 (220389_at)GNL1 /// LOC285831 (228857_at)NAAA (227135_at)WIPI2 (226986_at)HLA−E (200905_x_at)WFS1 (202908_at)OSTM1 (235198_at)RNF170 (226104_at)RNASET2 (217984_at)C9orf150 (227443_at)SLC44A3 (228221_at)CPPED1 (218610_s_at)RAPH1 (231075_x_at)−−− (231258_at)−−− (238967_at)CFLAR (208485_x_at)NOMO1 /// NOMO2 /// NOMO3 (221853_s_at)EDIL3 (207379_at)CPEB2 (235479_at)CFLAR (209508_x_at)CFLAR (211862_x_at)−−− (226865_at)TNFRSF10B (210405_x_at)TNFRSF10A (1552648_a_at)HLA−E (200904_at)IL12A (207160_at)ULBP2 (221291_at)YIPF3 (216338_s_at)LOC100133166 /// NBR1 (201383_s_at)TNFRSF10B (209295_at)TSPAN13 (217979_at)CTNND1 (208407_s_at)PGM2L1 (229553_at)KCNJ15 (210119_at)DYNC1LI2 (224616_at)CERCAM (224794_s_at)MPPE1 (209858_x_at)GCNT2 (211020_at)TAP1 (202307_s_at)SERINC3 (221472_at)TMBIM1 (217730_at)TMEM47 (209655_s_at)−−− (227193_at)−−− (49111_at)TIMP3 (201148_s_at)DHRS7 (213868_s_at)LRP10 (201412_at)SLC16A6 (230748_at)FANK1 (232968_at)CLU (208792_s_at)MAFK (226206_at)C2orf24 (200070_at)IDS (217432_s_at)EPB41L5 (220977_x_at)STC1 (204595_s_at)TNFRSF11B (204933_s_at)SLC17A5 (221041_s_at)SQSTM1 (201471_s_at)HBBP1 (216063_at)DKFZP564O0823 (204687_at)−−− (227318_at)PRKACB (202742_s_at)L1CAM (204584_at)−−− (238548_at)CALCOCO2 (235076_at)CPEB4 (224828_at)LRRC37A3 (229962_at)MPZL1 (201874_at)LOC644215 /// MTDH (1559822_s_at)STAT3 (208991_at)SYNE1 (209447_at)KDSR (202419_at)ARMC9 (219636_s_at)MARK4 (55065_at)RAPH1 (225189_s_at)HERC6 (219352_at)BEST3 (237003_at)ADAMTS8 (235649_at)−−− (1556138_a_at)TNFSF13B (223501_at)ENPP4 (204161_s_at)PDE11A (237248_at)MYOZ2 (213782_s_at)IL17D (227401_at)WDR78 (220769_s_at)MASP1 (232224_at)DDR1 (208779_x_at)FAM117B (1564868_a_at)MAFG (224466_s_at)PDGFRA (215305_at)BOC (225990_at)STBD1 (203986_at)LAMB1 (211651_s_at)OBFC2A (219334_s_at)CADM1 (209030_s_at)LGALS3BP /// LOC100133842 (200923_at)MEG3 (226210_s_at)ANGPTL2 (219514_at)SIL1 (218436_at)−−− (210824_at)−−− (231259_s_at)SLC26A2 (205097_at)HIST1H2BG (210387_at)HAPLN1 (230204_at)HIPK3 (207764_s_at)−−− (1570574_at)TMEM178 (229302_at)P2RX5 (210448_s_at)LHFP (218656_s_at)STYK1 (221696_s_at)ERAP2 (1554273_a_at)GPR155 (231166_at)ITPRIPL2 (227954_at)SEC62 (225352_at)CALCOCO1 (209002_s_at)BMP2 (205290_s_at)FILIP1L (1554966_a_at)CLDN1 (218182_s_at)OGFRL1 (226810_at)IGFBP7 (201162_at)CCPG1 (221511_x_at)ADAMTS12 (226997_at)PDE11A (224224_s_at)PRKACB (202741_at)THBS1 (235086_at)SEMA6D (226492_at)VAMP2 (201556_s_at)TRPA1 (217590_s_at)ITPRIPL2 (227792_at)MOAP1 (212508_at)ISG15 (205483_s_at)−−− (213808_at)HAPLN1 (230895_at)SERPIND1 (205576_at)KIAA0892 (227465_at)C5orf41 (225956_at)PLEKHH2 (227148_at)GDF15 (221577_x_at)KIAA1107 (1558293_at)CMTM6 (223047_at)KIF1C (209244_s_at)ZDHHC5 (224868_at)PCNX (229287_at)ABHD14B (224821_at)RNF10 (207801_s_at)CD163L1 (223655_at)−−− (226542_at)CCNL2 (232274_at)OGFRL1 (238469_at)SLC35F5 (225872_at)TMEM47 (209656_s_at)FGF2 (204422_s_at)SPATA18 (229331_at)ERAP2 (227462_at)EHF (224189_x_at)ETV5 (230102_at)TSC22D1 (215111_s_at)GBP3 (223434_at)GPR177 (221958_s_at)RSU1 (201980_s_at)FAM134A (222129_at)C2orf30 (224628_at)GDF11 (226232_at)SERINC3 (221471_at)C1orf63 (209007_s_at)TMEM59 (200620_at)AFF1 (201924_at)TMTC1 (226322_at)GCNT2 (230788_at)FAM3C (201889_at)SCD5 (224901_at)ARL6IP5 (200761_s_at)ASAH1 (213702_x_at)ANO4 (239883_s_at)PERP (222392_x_at)CD46 (208783_s_at)ITGA2 (227314_at)DUSP6 (208891_at)CABLES1 (225532_at)PAPSS2 (203060_s_at)C1orf183 (229382_at)NPDC1 (218086_at)TRIM22 (213293_s_at)C6orf203 (223576_at)−−− (227252_at)PRSS23 (226279_at)NFAT5 (224984_at)EPB41L5 (225855_at)NCOA7 (225344_at)−−− (225950_at)SLC33A1 (203165_s_at)RBMS2 (235558_at)KLHDC10 (210111_s_at)FAM55C (243606_at)BVES (228783_at)−−− (238726_at)C7orf25 (53202_at)UACA (236715_x_at)EDIL3 (225275_at)−−− (227061_at)CXCR4 (217028_at)DMXL2 (212820_at)SELT (225561_at)DPP4 (203716_s_at)TSPAN12 (219274_at)MAP1A (203151_at)SYTL4 (227703_s_at)SAP18 (208741_at)TMEM111 (217882_at)MFSD1 (218109_s_at)CCDC68 (220180_at)CSGALNACT2 (218871_x_at)GNAQ (224861_at)SLC4A11 (223748_at)ANGPTL2 (213004_at)TSGA10 (220623_s_at)RETSAT (218124_at)SRPX2 (205499_at)MAN2B2 (214703_s_at)TGFB2 (209909_s_at)AMIGO1 (226718_at)REEP5 (208872_s_at)DUSP6 (208893_s_at)SAMD9L (235643_at)C15orf48 (223484_at)GDE1 (226214_at)OBFC2A (233085_s_at)CLCC1 (207855_s_at)HMGCS1 (221750_at)C7 (202992_at)HIST1H2BK (209806_at)HTR7 (236281_x_at)−−− (231550_at)SETD7 (224928_at)SIAE (224391_s_at)LMLN (244881_at)NKIRAS1 (225930_at)ATP6AP1 (207809_s_at)SCUBE3 (230290_at)SH3KBP1 (1554168_a_at)TTC14 (225180_at)BID (227143_s_at)STAT3 (208992_s_at)SARNP (229069_at)GAS6 /// LOC100133684 (1598_g_at)SAT1 (213988_s_at)LAMP2 (226671_at)PBXIP1 (214177_s_at)ZBTB47 (226484_at)GABARAPL1 (208869_s_at)FAM84A (225667_s_at)PAPPA (224942_at)MMP2 (201069_at)−−− (243710_at)−−− (232110_at)−−− (225725_at)ADAMTS5 (235368_at)WFDC1 (219478_at)COX7A1 (204570_at)SLC16A2 (204462_s_at)CLEC2B (209732_at)PAPPA (224940_s_at)BMP2 (205289_at)−−− (214176_s_at)HBG1 /// HBG2 (213515_x_at)TNFRSF10D (227345_at)PS1TP4 (226381_at)STX12 (212112_s_at)CLDN1 (222549_at)DPP4 (211478_s_at)IDS (212221_x_at)SGMS2 (227038_at)FAM165B (228239_at)C1orf134 (244834_at)NCRNA00084 (224565_at)ZDHHC21 (235068_at)TM2D1 (213883_s_at)PCYOX1 (225274_at)TOB1 (202704_at)DNAJB9 (202842_s_at)−−− (228835_at)PSAP (200866_s_at)USP53 (237465_at)BSDC1 (222200_s_at)YPEL5 (217783_s_at)−−− (226297_at)−−− (243495_s_at)C10orf97 (218297_at)COPZ2 (219561_at)−−− (229072_at)SMURF2 (227489_at)SCUBE3 (230253_at)ANGPTL4 (221009_s_at)OGFRL1 (219582_at)DKK2 (219908_at)LCE2B (207710_at)ZBTB47 (226500_at)MGLL (225102_at)CCND1 (208712_at)IFITM3 (212203_x_at)IFITM1 (201601_x_at)FAM177A1 (227029_at)NIPSNAP3A (224436_s_at)BVES (223853_at)FAM13B (218518_at)RSL1D1 (213750_at)YPEL2 (227020_at)GFRA1 (205696_s_at)HINT3 (228697_at)C5orf28 (219029_at)TMEM77 (225228_at)SCAMP3 (201771_at)−−− (227755_at)EDEM2 (49679_s_at)PCDHB2 (231725_at)GSK3B (226183_at)−−− (1555904_at)LOC286059 (234147_at)−−− (205728_at)HBB (217232_x_at)−−− (232656_at)TMBIM4 (222845_x_at)IL8 (211506_s_at)ATP8B2 (226771_at)TFAP2C (205286_at)−−− (1558105_a_at)PLGLB1 /// PLGLB2 (205871_at)PITPNA (201190_s_at)CDIPT (201253_s_at)IDS (202438_x_at)MASP1 (213749_at)C5orf32 (224707_at)RIOK3 (202131_s_at)C10orf32 (225334_at)ATP6V1A (201972_at)GTF2IRD2 /// GTF2IRD2B /// LOC100133748 (215569_at)ANKRD46 (212731_at)ELMOD1 (231930_at)−−− (241685_x_at)CDKN2B (236313_at)SH3BGR (204979_s_at)FYCO1 (218204_s_at)VAMP3 (211749_s_at)GLIPR1 (226142_at)LOC644450 (1566145_s_at)SEPT8 (226627_at)ATP6V0E1 (214150_x_at)SLC14A1 (205856_at)LOC201229 (213195_at)SVIL (202566_s_at)MXRA5 (209596_at)STC1 (204596_s_at)CCDC50 (226713_at)TGFBR2 (207334_s_at)APLP2 (208703_s_at)C5orf15 (203024_s_at)−−− (1556123_a_at)DHRS1 (213279_at)RAB7L1 (218699_at)GLRX (209276_s_at)MAP1LC3B (208786_s_at)DUSP3 (201536_at)TMEM159 (213272_s_at)NCRNA00081 (228993_s_at)ATP6AP2 (201444_s_at)USP46 (203870_at)RIOK3 (202130_at)CCDC50 (236831_at)TM9SF1 (209150_s_at)LOC344595 (239466_at)−−− (229242_at)SOX6 (227498_at)BAG3 (217911_s_at)UBE2H (222421_at)MCTP2 (229021_at)NDUFAF4 (227559_at)SVEP1 (219552_at)MLLT11 (211071_s_at)STX12 (212111_at)−−− (202377_at)PPP1R3C (204284_at)DYNLT3 (203303_at)DUSP6 (208892_s_at)TGFBR2 (208944_at)SLC26A2 (224959_at)ARRDC4 (225283_at)SERPINE2 (212190_at)IRF1 (238725_at)BPGM (203502_at)IFI6 (204415_at)−−− (226550_at)ATP6V0E1 (200096_s_at)C14orf149 (227699_at)PIP5K1C (212518_at)TMBIM4 (223892_s_at)THRB (229657_at)LASS2 (222212_s_at)IFI30 (201422_at)−−− (232072_at)SBDS /// SBDSP (1554089_s_at)CPPED1 (239135_at)BRP44 (202427_s_at)ANKRD1 (206029_at)TM2D1 (211703_s_at)SGSH (204293_at)BRF2 (218955_at)NRBP2 (225949_at)LRPAP1 (201186_at)ZMYM6 (213698_at)LOC727770 (237737_at)C11orf17 (242515_x_at)CSGLCA−T (55093_at)VEPH1 (234940_s_at)C5orf15 (229260_at)FOXQ1 (227475_at)MEG3 (227390_at)AFF1 (215451_s_at)NAAA (214765_s_at)PDE1C (236344_at)−−− (235456_at)C1orf102 (227359_at)MICA (205904_at)SMPD1 (209420_s_at)FAS (215719_x_at)ACYP2 (206833_s_at)HSPB8 (221667_s_at)AGT (202834_at)GBAP (210589_s_at)PDK4 (225207_at)PIR (207469_s_at)GHR (205498_at)LHCGR (207240_s_at)MAN2B1 (209166_s_at)WBSCR22 (207628_s_at)LOC344595 (235606_at)MEG3 (212732_at)CYTH2 (1555842_at)ZNF224 (220019_s_at)TSPAN12 (230625_s_at)LIN7B (219760_at)CDADC1 (221015_s_at)PDE1C (1554378_a_at)FAM45A /// FAM45B (222955_s_at)C7orf25 (221573_at)C6orf89 (224987_at)LOC149832 (230502_s_at)CAV2 (213426_s_at)PSG4 (1568999_at)DOK4 (209691_s_at)ANK1 (207087_x_at)MBNL2 (205017_s_at)PCYT1A (204209_at)−−− (231676_s_at)−−− (1557242_at)CSNK1E (222015_at)TACC1 (217433_at)THBS1 (201107_s_at)TMEM63B (225271_at)HGSNAT (238090_at)LDLR (217173_s_at)SLC35E1 (227518_at)−−− (1557295_a_at)GOLSYN (218692_at)PARP9 (223220_s_at)APBB1IP (230925_at)TRIM23 (210994_x_at)C16orf5 (223960_s_at)FRK (207178_s_at)−−− (238734_at)VRK3 (239190_at)IFNA1 (208375_at)MEGF10 (232523_at)PSG5 (239583_x_at)ALG5 (222556_at)APOL2 (221653_x_at)SAMD9L (226603_at)RAB40B (204547_at)OPN3 (219032_x_at)MRPL32 (225260_s_at)PRUNE2 (212805_at)DYNC1LI1 (217976_s_at)KCNMA1 (221584_s_at)ABCB1 (209993_at)SVEP1 (213247_at)ADAM23 (244463_at)MPPE1 (213727_x_at)IFT20 (210312_s_at)BTN2A2 (205298_s_at)PIP4K2C (218942_at)ABLIM3 (205730_s_at)SEC62 (208943_s_at)PEX19 (201707_at)BTN3A3 (38241_at)CYB5R1 (202263_at)LOC202451 (228051_at)SYTL4 (229991_s_at)RTN1 (203485_at)TPRG1L (224871_at)LPIN1 (212274_at)PRRT3 (1556308_at)CAMLG (203538_at)SYT11 (209197_at)RAB9A (221808_at)NLGN2 (226288_s_at)MFAP3L (205442_at)NAPB (225111_s_at)PTPRA (213795_s_at)TNIP1 (243423_at)LOC100129550 (229699_at)SHANK2 (243681_at)C3orf62 (241817_at)KIAA0513 (204546_at)−−− (226399_at)FDFT1 (210950_s_at)ERP44 (208957_at)KIAA1377 (235956_at)−−− (238767_at)STS (203770_s_at)−−− (213114_at)AGAP3 (225789_at)KCND2 (207103_at)HAGH (205012_s_at)C6orf89 (224977_at)SLC10A3 (204928_s_at)NUB1 (222512_at)TBC1D2B (230377_s_at)ATOH8 (228890_at)TACR1 (230908_at)TBC1D24 (227908_at)C19orf42 (221988_at)ZNHIT6 (218932_at)TP53I3 (210609_s_at)LPCAT2 (229791_at)KLHL21 (203068_at)NHEDC2 (1564746_at)GADD45A (203725_at)RNF7 (224439_x_at)ZFYVE1 (223387_at)SLC12A4 (209402_s_at)TNFRSF10D (210654_at)FAM82B (222665_at)PURA (204020_at)PRRG1 (205618_at)CD46 (207549_x_at)CD44 (209835_x_at)CD44 (229221_at)NT5E (1553995_a_at)−−− (230795_at)ANTXR1 (220092_s_at)NRG1 (208231_at)ABTB2 (213497_at)−−− (229735_s_at)DDRGK1 (218159_at)PVR (216283_s_at)−−− (213448_at)MXD1 (226275_at)SLC4A4 (210738_s_at)SLC48A1 (48106_at)DYNC1LI2 (224614_at)RNF152 (1553722_s_at)PREPL (212217_at)CCNDBP1 (223084_s_at)LY96 (206584_at)CSAD (221139_s_at)SLC11A2 (203125_x_at)EPHB2 (209589_s_at)MPZL1 (210087_s_at)SLC2A12 (235050_at)EXD2 (1555808_a_at)RNPC3 (226975_at)TTLL7 (219882_at)C12orf62 (225772_s_at)CAB39L (225914_s_at)LSM10 (225593_at)C11orf67 (221600_s_at)POLR2L (202586_at)RIOK3 (202129_s_at)−−− (239252_at)TXNDC17 (224511_s_at)STUB1 (227625_s_at)UBE2B (228588_s_at)KIAA1632 (228453_at)FMN2 (223618_at)CD99L2 (233825_s_at)KIAA1468 (225506_at)UNC13B (202893_at)−−− (243345_at)RNF7 (224395_s_at)ZBTB20 (235308_at)GTF2A1L /// STON1 /// STON1−GTF2A1L (220190_s_at)YIF1A (202418_at)LRRC2 (231781_s_at)HAPLN3 (227262_at)CYTL1 (219837_s_at)NAGLU (204360_s_at)SMAD5OS (220263_at)SLC2A8 (218985_at)FAM45A (225351_at)LOC645513 (239556_at)−−− (230856_at)EHF (232361_s_at)VCAM1 (203868_s_at)CALD1 (231881_at)SVEP1 (224543_at)SC5DL (215064_at)KIAA1539 (207765_s_at)LHFP (231411_at)ACOX1 (209600_s_at)DLGAP4 (202572_s_at)−−− (240557_at)SORBS1 (218087_s_at)SLC31A1 (236217_at)PRMT2 (228722_at)ZNF436 (226114_at)ATP6V1E1 (208678_at)TAX1BP1 (200976_s_at)RNF14 (201823_s_at)LPCAT2 (227889_at)GPR137B (204137_at)CAPRIN1 (226285_at)ELTD1 (219134_at)RGL1 (209568_s_at)ENTPD4 (204076_at)CES2 (209667_at)LOC100129105 (241353_s_at)SPEG (232153_at)OR52K3P (232829_at)GPR155 (239533_at)CFTR (205043_at)NEO1 (229877_at)LIN7B (241957_x_at)ZNHIT1 (201541_s_at)WFS1 (1555270_a_at)EHF (222932_at)TMUB2 (218419_s_at)ENTPD5 (205757_at)MMP24 (213171_s_at)STOML1 (33736_at)ZDHHC24 (232091_s_at)FLJ22167 (219182_at)EDEM2 (218282_at)−−− (236527_at)DDR1 (1007_s_at)ADIPOR1 (217748_at)PGCP (203501_at)STOML1 (204701_s_at)FAM134C (212697_at)SYNPO2 (232119_at)RER1 (202297_s_at)IRGQ (64488_at)NAP1L2 (219368_at)ORMDL3 (223259_at)VNN1 (1558549_s_at)GRK4 (208365_s_at)ACVR1 (203935_at)NOL3 (59625_at)VAT1 (208626_s_at)DRP2 (207648_at)RAB6B (210127_at)RPL37 (224767_at)MAST3 (213045_at)ATXN7L1 (227732_at)SMCR7L (204594_s_at)CYBASC3 (224735_at)ZNFX1 (225076_s_at)CXCL10 (204533_at)TCEAL1 (204045_at)ABHD6 (45288_at)CLGN (205830_at)−−− (1561673_at)AHNAK2 (212992_at)RAB4B (228521_s_at)C18orf1 (209574_s_at)DDR1 (210749_x_at)FBXO2 (228036_s_at)DISP1 (228184_at)SLC35F2 (218826_at)RNF7 (218286_s_at)ARMCX6 /// LOC653354 (214749_s_at)ZNF791 (227122_at)COL27A1 (225288_at)PML (239582_at)PIGS (223148_at)PSG1 (210196_s_at)−−− (230343_at)ZDHHC21 (243835_at)SLC2A12 (244353_s_at)−−− (244117_at)PI4K2A (215134_at)GBX2 (210560_at)MMAA (242702_at)ZNF229 (235717_at)STOX2 (231969_at)−−− (229189_s_at)LEPR (207255_at)CYLD (221903_s_at)C1orf52 (239038_at)GUCA1B (235528_at)LAS1L (235541_at)AKD2 (1552299_at)MAP3K12 (205448_s_at)RAB11FIP1 (225177_at)MPHOSPH6 (1554906_a_at)PPP1R10 (201703_s_at)RPL23 (214744_s_at)LOC284023 (238096_at)CXCL11 (210163_at)PLA2R1 (240039_at)IFIH1 (219209_at)COL25A1 (1555253_at)ALS2CL (243276_at)PLCB4 (240728_at)−−− (239866_at)NEGR1 (239548_at)BID (211725_s_at)EIF4ENIF1 (242291_at)DRAM (241992_at)PELO (1560359_at)LOC439911 (1558345_a_at)CST3 (237623_at)LOC387647 (230736_at)BFSP1 (206746_at)TRADD (205641_s_at)PIGN (219048_at)ACOT8 (236514_at)−−− (229580_at)PIK3CA (231854_at)C12orf47 (64432_at)CTPS2 (222819_at)ZEB1 (239952_at)SLC39A8 (228945_s_at)−−− (241434_at)KIAA0141 (238659_at)AKR1C1 (1562102_at)TF (203400_s_at)LOC284751 (1556896_at)DHRSX (238053_at)PHTF1 (210191_s_at)LOC100127971 (237790_at)RUNX3 (204198_s_at)CNPY3 (228369_at)HEY1 (218839_at)IPO13 (203546_at)−−− (236063_at)HNRNPC (235500_at)LRP6 (34697_at)−−− (239543_s_at)ABHD4 (242023_at)WDR78 (229816_at)PIK3R2 (1568629_s_at)AHSA2 (226334_s_at)C14orf50 (237654_at)−−− (240233_at)STK16 (238572_at)OR2W3 (241881_at)−−− (1557383_a_at)ARHGAP22 (1560821_at)DHRS7 (236332_at)PLA2R1 (210194_at)HIST1H2AK (239041_at)TNFSF10 (202687_s_at)ST7L (1552738_a_at)LMOD1 (203766_s_at)KPNA5 (227934_at)RTCD1 (215351_at)−−− (1565734_at)−−− (242404_at)−−− (244433_at)ZXDB (216013_at)FLJ35390 (1564207_at)B3GALT1 (222969_at)RGS7 (206290_s_at)−−− (239064_at)LOC642103 /// MGAM (206522_at)FITM2 (233061_at)TFEC (206715_at)KIF5A (223933_at)−−− (241321_at)−−− (229554_at)−−− (235302_at)TTLL11 (242545_at)ATRNL1 (213744_at)CAB39L (225915_at)SNRPN (226591_at)PREPL (243542_at)−−− (1569344_a_at)C1orf91 (223656_s_at)EIF4E3 (225939_at)CEACAM19 (230504_at)CCDC157 (242949_x_at)JUP (201015_s_at)CCDC148 (231504_at)PNPLA2 (212705_x_at)CPE (201117_s_at)−−− (1570349_at)MRGPRX3 (1553293_at)OAS2 (204972_at)LOC729806 (217544_at)IL6R (226333_at)AP1S1 (205196_s_at)LOC151760 (1564838_a_at)−−− (230278_at)RGS9 (206518_s_at)RUNDC3B (215321_at)−−− (242866_x_at)ETV5 (231083_at)SPATA20 (218164_at)GRN (211284_s_at)PNPLA2 (213862_at)LOC100130506 (236656_s_at)TMED3 (208837_at)−−− (235078_at)ANK3 (209442_x_at)−−− (231467_at)G6PC3 (44654_at)NBEAL1 (1554106_at)ARSD (225280_x_at)PRKAB2 (214474_at)XPNPEP1 (222072_at)LMBR1L (220036_s_at)C20orf112 (230954_at)NR1D1 /// THRA (31637_s_at)NBR1 (1568857_a_at)SNAPC3 (222286_at)SHISA4 (226674_at)TECPR1 (227580_s_at)SPAG1 (210117_at)TLR3 (206271_at)FZD8 (224325_at)BLZF1 (1558560_s_at)TCP11L2 (1559413_at)GREB1 (205862_at)HISPPD2A (1555255_a_at)GGTA1 (228376_at)−−− (242818_x_at)WDR5B (235850_at)C1orf183 (220476_s_at)CYP2E1 (209975_at)−−− (243990_at)RSU1 (1560937_at)TMEM57 (241364_at)KRTAP4−8 (234631_at)−−− (236596_at)−−− (243947_s_at)−−− (242134_at)−−− (238782_at)CMTM4 (225009_at)FAR2 (239108_at)CPEB4 (224831_at)ABHD4 (218581_at)KGFLP2 (231031_at)C17orf39 (228452_at)CCNG2 (202770_s_at)YPEL3 (223179_at)APBB2 (212985_at)UTS2D (243175_at)TTC17 (218972_at)FBXL17 (242034_at)ZNF451 (215012_at)GSDMB (240701_at)ARL2BP (202092_s_at)−−− (215306_at)MCART1 (238574_at)SLC22A17 (218675_at)OSBPL2 (209222_s_at)DACH1 (228915_at)EFCAB6 (233839_at)LOC643837 (235497_at)−−− (236402_at)DGCR11 (215725_at)−−− (239302_s_at)UBE2Q1 (222480_at)ANKDD1A (229497_at)CDC37L1 (219343_at)RNLS (220564_at)PRLR (243755_at)CDKL3 (219831_at)SIRT4 (220047_at)FAM63A (221856_s_at)PLA2G16 (209581_at)ESM1 (208394_x_at)BAZ2A (201355_s_at)APLP2 (208704_x_at)WDR42A (202250_s_at)MORC4 (219038_at)IL13RA2 (206172_at)MMP10 (205680_at)GPR65 (214467_at)ZMAT3 (1555609_a_at)CCDC45 (223815_at)−−− (228811_at)LPPR2 (64899_at)EIF4EBP2 (224645_at)STIM2 (234140_s_at)HIST2H2BE (202708_s_at)DNER (226281_at)ZNF226 (219603_s_at)INSC (237056_at)TRPV2 (219282_s_at)ASAH1 (1555419_a_at)BTRC (224471_s_at)DPH3 (225200_at)TACC1 (200911_s_at)TMEM9B (222507_s_at)−−− (230333_at)SLC33A1 (203164_at)ABCC5 (226363_at)TP53INP1 (244721_at)ATP10A (214255_at)−−− (238951_at)TCTA (203054_s_at)LOC100133665 /// TALDO1 (201463_s_at)CHURC1 (226736_at)NACC2 (212993_at)MFSD7 (205144_at)RTN3 (219549_s_at)C17orf63 (222641_s_at)ACOX1 (213501_at)SEC11C (223299_at)RAB21 (203885_at)ZPLD1 (1561969_at)TMEM129 (225588_s_at)MAN2A2 (219999_at)HGSNAT (227564_at)LASS5 (224951_at)MURC (241749_at)HSD17B6 (37512_at)TRAF3IP1 (214458_at)MCAM (209087_x_at)PLA2R1 (235746_s_at)GNPTG (224887_at)LOC100130938 (230574_at)−−− (226725_at)KIAA1370 (225327_at)STEAP3 (218424_s_at)USP18 (219211_at)APLP2 (208248_x_at)RUSC2 (213066_at)CPPED1 (222686_s_at)−−− (238936_at)TGFB2 (228121_at)ECM1 (209365_s_at)HGSNAT (218017_s_at)PDLIM1 (208690_s_at)C14orf28 (238647_at)ELFN2 (1559072_a_at)MARCH2 (210075_at)MXD1 (206877_at)QSOX1 (201482_at)LOC100130506 (236657_at)LGR4 (218326_s_at)FBXL17 (227203_at)HOXB6 (205366_s_at)EZH1 (32259_at)RBM24 (235004_at)POPDC3 (219926_at)RPRD1A (225953_at)PNPLA3 (233030_at)FAM174A (226752_at)EDEM2 (221953_s_at)−−− (230728_at)PDCD4 (212593_s_at)BTN3A3 (204821_at)SLC44A1 (228486_at)SCG5 (203889_at)BCL2L13 (217955_at)FAM84A (234335_s_at)MBTPS2 (226760_at)RUNX1 (210365_at)−−− (230523_at)PLEKHA3 (223370_at)RASGRF2 (228109_at)ALPK2 (228367_at)TSC22D3 (208763_s_at)KIAA0247 (202181_at)−−− (242751_at)−−− (236599_at)LOC283070 (226382_at)HERC2P2 /// HERC2P3 /// LOC440248 (217317_s_at)−−− (231055_at)−−− (226250_at)TPP1 (200742_s_at)TPCN1 (217914_at)−−− (229810_at)PAIP2B (221868_at)−−− (222824_at)PPP1R3C (240187_at)AGTRAP (238135_at)LRRC37A2 (221740_x_at)STX7 (212632_at)TMEM22 (219569_s_at)PQLC3 (225579_at)TRIM23 (204732_s_at)TSC1 (209390_at)TMEM57 (218562_s_at)TMX4 (201581_at)RSAD1 (218307_at)ADPGK (220980_s_at)FBXO9 (1566509_s_at)TNFAIP1 (201207_at)RNASET2 (217983_s_at)ABCC5 (209380_s_at)RWDD2A (213555_at)FRY (214318_s_at)OPTN (202074_s_at)LOC151162 /// MGAT5 (212098_at)−−− (213675_at)SEMA6A (215028_at)PDE10A (205501_at)PRKACB (235780_at)SS18L1 (213140_s_at)CASP4 (209310_s_at)LOC645513 (242305_at)KCTD7 (1553717_at)C17orf86 (221621_at)BRWD1 (225446_at)LOC100129250 (78383_at)TM2D1 (212963_at)RASGRP3 (205801_s_at)OAS1 (205552_s_at)FLJ22167 (64900_at)C22orf9 (217118_s_at)EDN1 (1564630_at)ADRBK2 (204184_s_at)SAMD9 (219691_at)ZNF582 (241602_at)−−− (238932_at)TMEM50B (225182_at)AMY1A /// AMY1B /// AMY1C /// AMY2A /// AMY2B (208498_s_at)−−− (226125_at)SEC31B (209889_at)B3GNT1 (203188_at)FBXO9 (210638_s_at)TM9SF3 (224755_at)DMD (208086_s_at)ERMAP (219905_at)SLC39A11 (227046_at)PCDHB10 (223854_at)TRAK1 (202080_s_at)−−− (238466_at)LOC100130331 (215970_at)PITPNC1 (229414_at)DAB2 (201279_s_at)DRP2 (1556627_at)PDE5A (240088_at)−−− (239039_at)MAPRE2 (213489_at)PLEKHH2 (239568_at)ATP2C1 (209934_s_at)SP100 (210218_s_at)ATP6V0A4 (220197_at)SAMD9 (228531_at)STAT1 (AFFX−HUMISGF3A/M97935_3_at)LEPR (211356_x_at)SLC22A4 (205896_at)PSMC2 (201067_at)SLC41A2 (243894_at)CLEC2B (1556209_at)TRAK2 (202124_s_at)CAV2 (203324_s_at)CYBRD1 (222453_at)−−− (227278_at)FTH1 (214211_at)AK3 (224151_s_at)ITFG1 (1556151_at)SKP1 (200711_s_at)C16orf72 (225183_at)UFM1 (218050_at)STAT1 (200887_s_at)IKBKB (209341_s_at)TANC1 (225308_s_at)−−− (235664_at)NDFIP1 (217800_s_at)ME1 (204058_at)GFPT1 (226886_at)AMFR (202203_s_at)−−− (229815_at)−−− (230886_at)SLC31A1 (203971_at)−−− (217604_at)PLEKHM3 (235360_at)ATP6AP2 (201443_s_at)RAPH1 (225188_at)RNF14 (201824_at)RTCD1 (238087_at)MAP4K4 (218181_s_at)MCAM (211340_s_at)DYNC1H1 (211928_at)CD44 (212063_at)−−− (230175_s_at)KIF1C (209245_s_at)KIF3A (213623_at)C5orf41 (225957_at)−−− (242181_at)CRYL1 (220753_s_at)EHF (225645_at)N4BP2L2 (214748_at)−−− (1570155_at)C4orf31 (219747_at)AMIGO2 (222108_at)RPL23AP7 (221634_at)SLC35A1 (203306_s_at)SLC41A2 (223798_at)RHBDD1 (226948_at)FAM82A1 (235349_at)CLCN3 (201733_at)DNAJB9 (202843_at)−−− (227623_at)TRAM1 (201398_s_at)CYP51A1 (202314_at)ATP6V0E1 (214244_s_at)SC4MOL (209146_at)TMTC1 (224397_s_at)−−− (231513_at)ITGA2 (205032_at)PRNP (201300_s_at)−−− (226941_at)CYB561 (209163_at)−−− (1559990_at)PCYOX1 (203803_at)SGIP1 (223672_at)MCFD2 (212245_at)GNAI1 (209576_at)CCPG1 (221156_x_at)DPP4 (203717_at)SCG2 (204035_at)PTX3 (206157_at)AKAP2 /// PALM2 /// PALM2−AKAP2 (202759_s_at)−−− (227082_at)MXRA7 (235836_at)ATP6V1C1 (202872_at)PALMD (218736_s_at)ABCB1 (243951_at)C14orf100 (223547_at)CCDC50 (235051_at)CYBRD1 (217889_s_at)SAMD4A (212845_at)CALD1 (201616_s_at)DGKA (203385_at)HYPK /// SERF2 (226692_at)VNN1 (205844_at)SLITRK6 (232176_at)PAPPA2 (228237_at)RAB6B (225259_at)NCOA3 (209061_at)CD55 (201925_s_at)LOC90110 (226842_at)TNS3 (217853_at)PHKA1 (229876_at)KLHL7 (223250_at)−−− (237311_at)−−− (227089_at)−−− (229130_at)LAMB1 (201505_at)ZCCHC6 (220933_s_at)PDIA5 (203857_s_at)APLP2 (211404_s_at)HK2 (202934_at)KDELR3 (207265_s_at)SLC31A1 (235013_at)GNL1 (239068_at)PLA2G4C (209785_s_at)OS9 (200714_x_at)IDUA (213723_s_at)GSN (200696_s_at)BCAP29 (225674_at)C15orf57 (1560814_a_at)ADAM28 (205997_at)MINPP1 (209585_s_at)PDCD4 (212594_at)YIPF5 (224934_at)MKL1 (215291_at)PCDHB14 (231726_at)−−− (237212_at)ZDHHC5 (224858_at)FAM134A (221983_at)DEGS1 (207431_s_at)GNAI1 (227692_at)ZNF846 (1569157_s_at)TBC1D9B (206431_x_at)LOC100132969 /// TMEM185A (227880_s_at)ZNF600 (242463_x_at)IRGQ (1555833_a_at)LOC645513 (1561760_s_at)−−− (1568876_a_at)LOC100133166 /// NBR1 (201384_s_at)SYT17 (229053_at)ZNF449 (228968_at)C5orf56 (1564276_at)LRP12 (220253_s_at)DTNA (211493_x_at)NME5 (206197_at)−−− (227115_at)SLC8A3 (1562403_a_at)TMEM187 (204340_at)FLJ44054 (1570447_at)PSG9 (207733_x_at)IL21R (221658_s_at)TAPT1 (226735_at)ZNF23 (213934_s_at)PON2 (210830_s_at)NUDT4 (212183_at)−−− (221788_at)CTBS (218924_s_at)ATRNL1 (213745_at)MCEE (226238_at)SP100 (202864_s_at)RNF10 (208632_at)SPAG8 (206816_s_at)SLC39A8 (216504_s_at)LOC149832 (228456_s_at)ARHGEF3 (218501_at)ERCC5 (202414_at)TARSL2 (227611_at)ATRN (212517_at)TMEM38A (222896_at)VAMP1 (213326_at)ANKH (223092_at)RAB30 (227842_at)AKR1B1 (201272_at)PRDM1 (217192_s_at)SH3PXD2A (224817_at)RAI14 (202052_s_at)SEC62 (1552790_a_at)C6orf138 (234689_at)C17orf103 (226657_at)GLB1 (201576_s_at)PINK1 (209019_s_at)COL4A3BP (226277_at)DNASE1L1 (203912_s_at)KCTD4 (239787_at)GDPD1 (238681_at)TMEM167A (224702_at)ANKH (223094_s_at)NUMB (209073_s_at)SGCD (214492_at)−−− (244864_at)−−− (226681_at)CLN5 (214252_s_at)PURG (235634_at)MRVI1 (226047_at)AFF1 (211826_s_at)PGCP (208454_s_at)LYST (203518_at)DHRS7 (210788_s_at)SQLE (213562_s_at)OSTM1 (243287_s_at)IFNAR1 (225661_at)ANGPTL2 (213001_at)RGNEF (1560348_at)KIAA1324 (221874_at)TAC3 (219992_at)PAPPA (201982_s_at)COLEC10 (207420_at)−−− (231331_at)AKR1C1 (204151_x_at)ARHGAP25 (38149_at)−−− (236297_at)NAV1 (224770_s_at)−−− (214345_at)DDX58 (218943_s_at)BTRC (216091_s_at)SYNGR1 (204287_at)−−− (237083_at)−−− (241900_at)ZKSCAN1 (214670_at)WIPI1 (203827_at)QPRT (242414_at)LEPREL1 (218717_s_at)−−− (232715_at)PRICKLE2 (225968_at)CD44 (1557905_s_at)SEMA6A (225660_at)ZFAND2A (226650_at)PRDX6 (200844_s_at)MMP3 (205828_at)SYNPO2 (225721_at)ATP6V0E1 (201172_x_at)CCPG1 (222156_x_at)SLC20A1 (201920_at)TMTC1 (244506_at)C4orf49 (223734_at)GALNT1 (201723_s_at)−−− (225239_at)TGFB2 (220406_at)NCSTN (208759_at)−−− (1566146_x_at)MEG3 (226211_at)ACAA1 (214274_s_at)SLC1A1 (206396_at)−−− (1566144_at)MANEAL (231564_at)−−− (43511_s_at)CD9 (201005_at)NOMO1 /// NOMO2 /// NOMO3 (217225_x_at)PSG1 (210195_s_at)GLRB (205280_at)RGNEF (1554004_a_at)MEG3 (210794_s_at)CLIP3 (212358_at)CHL1 (204591_at)CTSD (200766_at)PERP (217744_s_at)LPPR2 (218509_at)SEMA6D (233801_s_at)LOC100131731 (1557263_s_at)THBS1 (239336_at)RPL10 (200724_at)LIMCH1 (212325_at)BCL2L2 (209311_at)DKFZP564O0823 (225809_at)ADAM19 (209765_at)HAPLN1 (205524_s_at)SEMA6D (220574_at)STOM (201060_x_at)ZFAND5 (229368_s_at)−−− (225123_at)PLXNA3 (203623_at)C1orf63 (209006_s_at)MAN2A1 (205105_at)−−− (235938_at)FGF9 (206404_at)−−− (1561754_at)PARD3B (228411_at)APH1B (226358_at)EVI5 (208297_s_at)ATF6 (217550_at)LRP6 (225745_at)TMEM9B (218065_s_at)PLCB4 (203895_at)SCUBE3 (228407_at)ADAMTS5 (229357_at)SLC14A1 (229151_at)SLC4A4 (203908_at)LRRN3 (209840_s_at)PSG9 (209594_x_at)PSG5 (204830_x_at)PSG4 (208191_x_at)PSG7 (205602_x_at)ANGPT1 (205609_at)KCNN2 (220116_at)CD44 (204490_s_at)ANO4 (229749_at)SERINC3 (211769_x_at)NRG1 (206237_s_at)ARL6IP5 (200760_s_at)ANTXR1 (227660_at)−−− (236278_at)−−− (1569664_at)WNT16 (224022_x_at)SERPINE2 (227487_s_at)STOM (201061_s_at)CD44 (212014_x_at)PCDH9 (219737_s_at)PSG2 (208134_x_at)PLCB4 (203896_s_at)−−− (1556346_at)TAP2 (204770_at)PSG1 (208257_x_at)CD44 (210916_s_at)BRP44 (227669_at)NEO1 (204321_at)ADAMTS5 (1558636_s_at)TMOD2 (219701_at)TRIM73 (1554250_s_at)−−− (227290_at)APOD (201525_at)CLN5 (204085_s_at)TRIM58 (215047_at)PCDHB16 (232099_at)−−− (226773_at)−−− (235561_at)KIF5A (205318_at)NUDT6 (230329_s_at)THAP2 (223588_at)SAP18 (208740_at)CCDC50 (225331_at)ADAMTS1 (222162_s_at)C6orf105 (229070_at)FAS (216252_x_at)CYP51A1 (216607_s_at)−−− (235556_at)COBLL1 (203642_s_at)WDR63 (243087_at)−−− (230313_at)SYNPO2 (244108_at)DNAJC6 (204720_s_at)TNFRSF21 (218856_at)CLCN3 (201735_s_at)GDPD1 (1555606_a_at)−−− (1560208_at)SLC12A8 (219874_at)SCUBE3 (217600_at)CXCR7 (212977_at)MPPE1 (206764_x_at)COQ10B (1561948_at)PNMA2 (209598_at)HSD17B12 (217869_at)TMEM127 (219460_s_at)ZMAT3 (219628_at)DTX4 (212611_at)TXNIP (201010_s_at)ANO4 (236420_s_at)−−− (227221_at)TRAM1 (201399_s_at)−−− (221973_at)TP53INP1 (235602_at)CDKN1A (202284_s_at)TMOD1 (203661_s_at)ARMCX3 (217858_s_at)PROS1 (207808_s_at)NAALADL2 (1557998_at)TSGA10 (223838_at)−−− (239671_at)GPR177 (228949_at)SERPINI1 (205352_at)CCND2 (200951_s_at)CCND2 (200953_s_at)HIST1H4B (232035_at)FOXE1 (206912_at)STXBP1 (202260_s_at)SEMA6A (223449_at)HAPLN1 (205523_at)TNFRSF10A (231775_at)GLS (203158_s_at)NRG1 (208230_s_at)NPC1 (202679_at)MXD1 (228846_at)LIMCH1 (212327_at)LOC643401 (1557765_at)OLR1 (210004_at)ADAMTS5 (219935_at)CCND2 (200952_s_at)SYNPO2 (225895_at)C5orf53 (241874_at)WIPI2 (214699_x_at)HBG1 /// HBG2 (204419_x_at)HBG1 /// HBG2 (204848_x_at)PIK3IP1 (221756_at)SYNPO2 (225894_at)−−− (1559462_at)−−− (1557241_a_at)LIMCH1 (212328_at)GALNT1 (1568618_a_at)TGFB2 (220407_s_at)ABCB1 /// ABCB4 (209994_s_at)VWA5A (205011_at)ACAD11 (225573_at)SLC1A1 (213664_at)C5orf56 (230405_at)IDS (202439_s_at)PGM2L1 (229256_at)HIST1H2AC (215071_s_at)ADAMTS1 (222486_s_at)ANGPT1 (205608_s_at)BAT5 (224756_s_at)INA (204465_s_at)PCDH9 (219738_s_at)NRG1 (206343_s_at)−−− (235666_at)ITGA8 (214265_at)RRM2B (223342_at)PCSK6 (207414_s_at)−−− (241898_at)SYNPO2 (225720_at)SLFN5 (1553055_a_at)COBLL1 (215393_s_at)SRPRB (218140_x_at)PINK1 (209018_s_at)SMURF2 (205596_s_at)IDI1 (208881_x_at)RND3 (212724_at)C14orf100 (223215_s_at)PRNP (215707_s_at)BTN2A1 (215493_x_at)TOR1B (209593_s_at)TEX2 (218099_at)DCBLD2 (213873_at)PHKA1 (205450_at)IDI1 (204615_x_at)PCYT1A (225069_at)TXNDC17 (228743_at)SLC26A2 (224963_at)NIPAL3 (225876_at)PSG6 (209738_x_at)PSG6 (208106_x_at)SHANK2 (213308_at)SP110 (209761_s_at)ALG5 (218203_at)LPAR1 (204037_at)−−− (241962_at)PDPK1 (224986_s_at)BAMBI (203304_at)PLA2G12A (242323_at)ATP6V0E1 (214149_s_at)PIK3IP1 (221757_at)−−− (230820_at)BTN2A1 (203944_x_at)YIPF6 (212342_at)CD36 (209555_s_at)PIGB (205452_at)PRICKLE1 (226065_at)PLEKHB2 (201410_at)C2orf30 (224630_at)TXNRD1 (201266_at)BTN2A1 (211256_x_at)DCBLD2 (224911_s_at)FAM45A /// FAM45B (221804_s_at)LACTB2 (222714_s_at)ARSD (225286_at)LOC647309 (1569616_at)MPZL1 (231621_at)FOXF2 (206377_at)SLC7A11 (209921_at)WNK1 (211994_at)SLC4A4 (210739_x_at)TNFRSF10B (209294_x_at)TERF2IP (201174_s_at)−−− (1568853_at)tcag7.1188 (1561254_at)GDE1 (202593_s_at)KYNU (204385_at)THRB (207044_at)SLC25A20 (203658_at)MYOZ2 (211476_at)CCDC80 (225242_s_at)KYNU (217388_s_at)CRTAP (226656_at)RNF103 (202636_at)KYNU (210663_s_at)BLCAP (201032_at)ADAM23 (206046_at)SLITRK5 (214930_at)C3 (217767_at)FAM82A2 (218126_at)ENPP4 (204160_s_at)ST3GAL5 (203217_s_at)CCDC113 (222890_at)MESDC2 (238679_at)SLC4A4 (211494_s_at)ARHGAP24 (230803_s_at)CD36 (206488_s_at)GDF11 (226234_at)SLC35E1 (229410_at)CCNG2 (211559_s_at)ACSF2 (218844_at)TCF21 (229529_at)SOD2 (221477_s_at)FGL2 (227265_at)KIAA1107 (214098_at)FAM117B (226431_at)PIGG (233654_at)−−− (230580_at)TMEM106B (226529_at)LSS (202245_at)GSTK1 (217751_at)ACAP2 (212477_at)TMEM205 (225003_at)PDE5A (1553175_s_at)C20orf108 (224693_at)SPATA18 (230723_at)ZDHHC14 (219247_s_at)XYLT2 (219401_at)PCDHB9 (223927_at)RAG1 (206591_at)PDCD4 (202730_s_at)WWTR1 (202132_at)PRKAB2 (1558027_s_at)−−− (240896_at)CYB561 (209164_s_at)REEP2 (205331_s_at)VNN2 (205922_at)−−− (230491_at)SYT16 (1554797_at)−−− (225328_at)WHAMML1 /// WHAMML2 (1557261_at)UBE2L6 (201649_at)KLHL24 (221985_at)IL10RB (209575_at)−−− (229921_at)ORAI3 (221864_at)GALNT5 (236129_at)LYST (210943_s_at)FAM65C (227654_at)−−− (215347_at)ABCC4 (1555039_a_at)NTM (222020_s_at)PPIC (204518_s_at)RHOJ (238905_at)UBE2H (222420_s_at)PCSK5 (213652_at)ETV5 (203348_s_at)GPRC5A (203108_at)C1orf216 (212791_at)−−− (239706_x_at)CRTAP (227138_at)XPR1 (226615_at)TMEM185A (1554105_at)COX19 (231831_at)−−− (243735_at)CLCC1 (230002_at)ACSL1 (207275_s_at)ANK2 (202921_s_at)−−− (233212_at)APOL2 (221013_s_at)DYNC2LI1 (203763_at)PLEKHH2 (243650_at)ADCY6 (209195_s_at)PCDHB13 (232415_at)ERCC6 (230108_at)IRGQ (221877_at)SLC41A3 (224931_at)PARD3B (1553190_s_at)−−− (232411_at)−−− (229417_at)−−− (226391_at)NT5DC1 (223178_s_at)TMEM41B (212622_at)NFKBIZ (223217_s_at)C1orf226 (227019_at)−−− (241853_at)−−− (213383_at)AIFM2 (228445_at)FKBP3 (222485_at)SDF4 (221972_s_at)AKAP6 (217669_s_at)−−− (1556332_at)TGM2 (211003_x_at)LOC100134190 /// LRP1 (200784_s_at)SREBF2 (201247_at)−−− (230605_at)DHRS3 (202481_at)RHOU (223168_at)LIN37 (213526_s_at)TMEM50B (228001_at)PAPPA2 (213332_at)PSMB10 (202659_at)MGAT1 (201126_s_at)UCHL1 (1555834_at)SQSTM1 (213112_s_at)DCTN1 (201082_s_at)C19orf66 (1555491_a_at)CPEB4 (224829_at)CCDC107 (229063_s_at)GPR153 (64942_at)LOC100128590 (1558920_at)LOC222070 (58900_at)C1orf50 (219406_at)LOC387723 (229323_at)VAMP7 (202829_s_at)PLA2R1 (207415_at)GGCX (235413_at)ROBO2 (226766_at)CLTB (211043_s_at)GPX3 (201348_at)TMEM198 (227890_at)MDGA1 (232237_at)ABHD6 (221679_s_at)GATA3 (209604_s_at)FLJ31715 (1553775_at)−−− (1557705_a_at)−−− (227943_at)SLC22A18 (204981_at)TMEM106A (1552303_a_at)DNAJC1 (222620_s_at)PRLR (231981_at)MMP12 (204580_at)C14orf179 (226195_at)APOL1 (209546_s_at)−−− (236616_at)MMAA (236347_at)RHBDD1 (227414_at)PARP12 (218543_s_at)FBXL2 (214436_at)MICALL2 (1555862_s_at)DNAJC5 (224611_s_at)LOC440552 (238199_x_at)LOC729776 (229444_at)RNFT1 (221195_at)APLP1 (209462_at)DNHD1 (242540_at)PITPNC1 (238649_at)SNPH (205104_at)C6orf192 (226301_at)TAPBP (210294_at)ZSCAN18 (218312_s_at)−−− (244799_s_at)CFHR2 (206910_x_at)CABLES1 (225531_at)SAMHD1 (1559883_s_at)PLD1 (177_at)CHST2 (203921_at)DACT3 (228228_at)ZNF44 (228718_at)NETO1 (1562713_a_at)TNFSF15 (221085_at)−−− (235893_at)KIAA1377 (236325_at)PRICKLE1 (226069_at)−−− (229968_at)−−− (213930_at)SGPP1 (223391_at)TMEM100 (219230_at)PPM1K (235061_at)WDR42A (202249_s_at)OS9 (215399_s_at)PELO (214660_at)FAM8A1 (203420_at)SEC63 (201916_s_at)SCD5 (224018_s_at)PLCXD3 (239270_at)IFI44L (204439_at)WHAMML2 (1557450_s_at)BEST4 (1552296_at)JAG1 (216268_s_at)RORA (210479_s_at)BTBD9 (229867_at)ZNF547 (1552794_a_at)DNAJC18 (227169_at)PGBD4 (243815_at)−−− (228742_at)−−− (1558481_s_at)C7orf53 (239203_at)MFSD6 (225325_at)KIAA0368 (212427_at)TTC9 (213174_at)DUSP27 (232252_at)ITPR1 (216944_s_at)KPNA5 (229317_at)VPS41 (235625_at)LOC401052 (232812_at)SERAC1 (232183_at)ZNF585A (229794_at)PDE10A (211170_s_at)EXOC6 (226259_at)−−− (230416_at)WDR22 (227251_at)CHURC1 (223210_at)PLCXD2 (235230_at)−−− (1560958_s_at)C15orf17 (224805_s_at)IQCK (213392_at)HIP1 (226364_at)USP30 (227572_at)RAB4A /// SPHAR (206272_at)LONP2 (221833_at)RAB3B (227123_at)−−− (227264_at)−−− (244787_at)OSBP (201800_s_at)TBCKL (226126_at)GGT7 (226470_at)ELOVL4 (219532_at)RASSF8 (225946_at)SP110 (209762_x_at)KIAA1024 (215081_at)KIAA0226 (212733_at)ZNF224 (244462_at)ZMYM5 (206744_s_at)FKRP (227882_at)MAGI2 (209737_at)DGKE (238694_at)ARV1 (223223_at)CCDC87 (219887_at)AKD2 (1564002_a_at)TGDS (208249_s_at)ANGEL1 (213099_at)PDE4DIP (213388_at)CDRT4 (228482_at)−−− (229948_at)DUSP22 /// LOC100134371 (226440_at)CD55 (1555950_a_at)−−− (235661_at)COX19 (235533_at)−−− (229297_at)SCPEP1 (218217_at)C1orf54 (219506_at)RDH10 (227467_at)−−− (235581_at)C22orf9 (212421_at)KIF3C (203389_at)MAP7D2 (228262_at)PSMD9 (209334_s_at)RASSF8 (207754_at)−−− (241417_at)HIST1H3E (214616_at)−−− (242907_at)DENND4A (214787_at)ZNF277 (218645_at)KIAA1377 (232166_at)RFX5 (202964_s_at)NFS1 (218455_at)PARP8 (219033_at)SIRPA (202896_s_at)FBXO31 (224162_s_at)TM9SF4 (212194_s_at)LOC729723 (239325_at)ADAM32 (1552266_at)−−− (241857_at)RPL27A (223707_at)ARL17P1 (1555964_at)TRIM69 (232792_at)TMEM168 (234726_s_at)WDR52 (221103_s_at)−−− (227492_at)LGR4 (230674_at)CD44 (234411_x_at)ATOH8 (1558706_a_at)−−− (241663_at)SOX6 (224178_s_at)ENC1 (201340_s_at)KLRD1 (210606_x_at)GSTA4 (235405_at)ZBTB11 (242433_at)PGM2L1 (235149_at)XRN1 (1570394_at)RASL11A (238353_at)−−− (239300_at)ZC3H6 (227809_at)ABCA8 (204719_at)FOXO4 (205451_at)−−− (228116_at)WDR78 (1554141_s_at)PLXNA3 (1567519_at)VAMP4 (213480_at)−−− (241128_at)AMMECR1L (223297_at)PVR (1556582_at)TMEM217 (237016_at)C16orf7 (205781_at)N4BP2L1 (229718_at)POLI (238992_at)SIRT5 (229112_at)NDST1 (1554010_at)−−− (233672_s_at)LONP2 (221834_at)ERP27 (227450_at)ABCC4 (243928_s_at)−−− (239329_at)GEMIN8 (230758_at)AKAP8L (218064_s_at)RAPGEF2 (203097_s_at)PSEN1 (203460_s_at)ACAD8 (221669_s_at)KCTD16 (233234_at)LOC728411 (235888_at)−−− (238212_at)TMEM38B (222735_at)C1orf27 (222720_x_at)TREM1 (219434_at)CDH10 (220115_s_at)RAB7L1 (218700_s_at)SLC41A3 (219175_s_at)IL31RA (243541_at)LACTB (1552485_at)SEMA6D (244746_at)−−− (236038_at)LSS (211018_at)CD36 (228766_at)ITGBL1 (1557080_s_at)SAA1 /// SAA2 (214456_x_at)TGOLN2 (1554608_at)DENND3 (212975_at)−−− (1558890_at)SSX2IP (203016_s_at)−−− (241863_x_at)KCTD21 (229873_at)PTAR1 (243995_at)−−− (1559991_s_at)SPIN3 (1555883_s_at)−−− (231431_s_at)TMEM167B (222495_at)CCDC127 (226515_at)GALNT10 (212256_at)RNF144B (228153_at)ARHGEF9 (203263_s_at)PTRH2 (218732_at)LAT /// SPNS1 (211005_at)RAB11FIP5 (210879_s_at)CMBL (227522_at)TMEM107 (224495_at)ABHD6 (221552_at)−−− (1554609_at)KIAA1632 (236108_at)NALCN (228608_at)EPHA4 (206114_at)KLHL29 (1554262_s_at)DIO2 (211215_x_at)KLHL20 (204177_s_at)TSPAN17 (225235_at)−−− (228292_at)AHCYL2 (215672_s_at)CHST3 (32094_at)CLINT1 (201768_s_at)DCBLD2 (213865_at)LASS1 (229448_at)NUDT16 (235054_at)TNFSF10 (214329_x_at)SCN3A (210432_s_at)RNF130 (217865_at)CATSPER2 (1561405_s_at)LOC653602 (229546_at)SIRPA (217024_x_at)LTBR (203005_at)MARCH9 (226454_at)PNMA2 (209597_s_at)VEPH1 (229760_at)IQCE (204202_at)UQCC (217935_s_at)LMLN (1553284_s_at)FUCA1 (202838_at)STIM2 (225250_at)ANXA11 (228727_at)SLC35B2 (224716_at)EXOC7 (212035_s_at)TMCC1 (213349_at)−−− (243955_at)TMEM136 (230186_at)−−− (242819_at)KLHL20 (210635_s_at)−−− (238568_s_at)GALM (235256_s_at)C1orf85 (1558693_s_at)CTSZ (212562_s_at)TRPS1 (234351_x_at)C5orf44 (218674_at)HELQ (228736_at)DNAH1 (228111_s_at)HK2 (222305_at)−−− (244397_at)PTK2 (241453_at)RPL5 /// RPL5P1 /// RPL5P34 (210034_s_at)−−− (237857_at)CHRNE (215916_at)−−− (239478_x_at)RBM18 (225236_at)TMEM140 (218999_at)TLCD1 (227804_at)C3orf34 (1553158_at)ZNF471 (211923_s_at)RAB3IP (238526_at)ADRB2 (206170_at)EXOC6 (233924_s_at)EPHA4 (228948_at)MFSD8 (229509_at)−−− (239624_at)ID2 (201566_x_at)−−− (217922_at)−−− (243515_at)C9orf85 (235866_at)HIPK2 (225097_at)−−− (241660_at)ZNF434 (218937_at)SLC38A4 (220786_s_at)−−− (230654_at)−−− (243366_s_at)ZNF25 (228185_at)ARHGAP12 (207606_s_at)LYSMD2 (226748_at)LRRC2 (219949_at)FRS2 (226045_at)ATAD1 (224850_at)CALCOCO2 (210817_s_at)LOC728190 (1558794_at)C9orf3 (212848_s_at)ATP5L (208745_at)MCTP2 (243109_at)ZNF862 (213444_at)CLIP4 (226425_at)PHTF1 (205702_at)IL21R (219971_at)PTAR1 (226110_at)HHEX (215933_s_at)THAP6 (227813_at)HBB (211696_x_at)IFIT2 (226757_at)LOC641467 (237745_at)KIAA1219 (224678_at)−−− (1559053_at)SGMS2 (242963_at)C10orf18 (227777_at)TMCC1 (213352_at)EPM2A (205231_s_at)MGAT4B (224598_at)RPL35A (238026_at)NAP1L5 (228063_s_at)DNAJC16 (212911_at)−−− (238718_at)−−− (243657_at)GALNT11 (219013_at)SC5DL (211423_s_at)PRSS23 (202458_at)BRF2 (218954_s_at)FNTA (209471_s_at)TK2 (204276_at)C15orf24 (217898_at)VWA5A (210102_at)SP110 (208012_x_at)PREPL (212216_at)TAP2 (225973_at)PCNXL2 (1554256_a_at)RASA1 (210621_s_at)C9orf44 (233525_s_at)−−− (235459_at)STAT1 (AFFX−HUMISGF3A/M97935_MB_at)LIG4 (227766_at)EXD2 (218363_at)SRPRB (227737_at)SLC30A1 (212907_at)HLA−DOB (205671_s_at)NAV3 (204823_at)GM2A (235678_at)SYNGR1 (210613_s_at)GOPC (225022_at)C10orf26 (202808_at)GORASP2 (207812_s_at)TAPT1 (227407_at)AQP11 (229526_at)VEGFC (209946_at)KIF3B (225205_at)RNF41 (201961_s_at)SLC9A6 (203909_at)NSDHL (215093_at)RRAGC (222514_at)CAP2 (212551_at)DAP3 (208822_s_at)TJP1 (214168_s_at)−−− (229571_at)−−− (230180_at)ORMDL1 (228801_at)−−− (1569263_at)DIAPH2 (217246_s_at)CLCA2 (206166_s_at)KIF9 (230701_x_at)ZNF471 (232117_at)POMT1 (218476_at)MGC31957 /// TNFRSF10C (210484_s_at)−−− (1568851_at)HS2ST1 (230465_at)ZFAND5 (217649_at)ID2 /// ID2B (213931_at)TMEM8 (222718_at)NEK10 (237227_at)SLC25A16 (214140_at)KIF3C (203390_s_at)−−− (217029_at)BLVRB (202201_at)GUK1 (200075_s_at)−−− (1557196_a_at)NDST2 (203916_at)C17orf39 (220058_at)PDE1C (207303_at)GDF11 (216860_s_at)TBC1D13 (44696_at)KLC1 (232036_at)BICD1 (1556051_a_at)−−− (242899_at)−−− (238309_x_at)FAM134A (218037_at)SLC29A1 (201802_at)−−− (1555989_at)SERTAD1 (223394_at)TMX4 (201580_s_at)INF2 (224469_s_at)MARCH4 (230112_at)GADD45B (209304_x_at)NSDHL (209279_s_at)FMN2 (1555471_a_at)CXXC5 (222996_s_at)CHST3 (208252_s_at)AK5 (222862_s_at)SEPT3 (223362_s_at)PLXNA2 (227032_at)MRPL2 (229884_s_at)−−− (237728_at)NAPA (208751_at)ID2 (201565_s_at)CYB5D1 (1552711_a_at)RNF144B (235549_at)ANK1 (205390_s_at)−−− (1557542_at)TNFSF9 (206907_at)BDH2 (235155_at)−−− (235924_at)SEMA4F (228660_x_at)−−− (1559062_at)SNRK (1564514_at)TMEM170B (235798_at)PCDHA1 /// PCDHA10 /// PCDHA11 /// PCDHA12 /// PCDHA13 /// PCDHA2 /// PCDHA3 /// PCDHA4 /// PCDHA5 /// PCDHA6 /// PCDHA7 /// PCDHA8 /// PCDHA9 /// PCDHAC1 /// PCDHAC2 (210674_s_at)GALNT10 (220296_at)FEZ2 (202305_s_at)ANKRD36B (220940_at)SVEP1 (236927_at)−−− (228918_at)MAP2K3 (215499_at)BTBD9 (1553375_at)CNOT3 (229143_at)−−− (229380_at)ERO1LB (220012_at)TRIM36 (219736_at)ANK1 (208352_x_at)C4orf36 (1552919_at)CLDND1 (239146_at)−−− (228971_at)SYT17 (205613_at)PCDHB8 (221319_at)DNAJA2 (226994_at)TSPO (202096_s_at)ZMYM6 (219924_s_at)CLSTN2 (219414_at)KIAA0319L (217929_s_at)SHANK2 (213307_at)−−− (230119_at)C17orf67 (236863_at)−−− (229885_at)WDR78 (1554140_at)−−− (1559310_at)FLJ39632 (242546_at)PURA (204021_s_at)ID1 (208937_s_at)PEX3 (203970_s_at)IDS (211782_at)GPR158 (232195_at)LOC652900 /// SEZ6L2 (218720_x_at)FLJ35848 (1562484_at)−−− (1568633_a_at)PURA (213806_at)DUSP28 (229211_at)NIPAL2 (222950_at)C3orf33 (1554176_a_at)FMO5 (215300_s_at)−−− (1565895_at)−−− (222378_at)ZNF319 (228460_at)EPB41L1 (212339_at)NMNAT2 (209755_at)FMN2 (1559244_at)−−− (244701_at)LTBR (232819_s_at)C1orf183 (241809_at)COMT (208817_at)ARD1A (203025_at)C7orf38 (1566865_at)HIST1H2AD /// HIST1H3D (214472_at)ZMYM5 (235620_x_at)IQSEC2 (229840_at)DDHD1 (225970_at)MORF4L2 (243683_at)FNDC4 (218843_at)ITGA8 (239092_at)ANK3 (207950_s_at)KIAA1688 (227876_at)MDM2 (237891_at)LOC340184 (1563589_at)−−− (217648_at)−−− (1556997_a_at)DUSP3 (201538_s_at)−−− (231439_at)−−− (213500_at)LOC285628 (232504_at)PRLR (211917_s_at)C19orf42 (224712_x_at)LOC728537 (230941_at)MAN1A2 (217921_at)MEG3 (222328_x_at)HLA−G (210514_x_at)HLA−F (204806_x_at)GPR37 (214586_at)−−− (226637_at)CHID1 (223061_at)DAP (201095_at)HLA−G (211528_x_at)C4orf34 (224990_at)SNAP29 (239084_at)OSBPL2 (209221_s_at)CRELD1 (203368_at)ZER1 (202456_s_at)FHL1 (210299_s_at)SLC25A23 (226010_at)EFEMP2 (209356_x_at)−−− (1566968_at)RHOJ (235131_at)NBL1 (37005_at)RBMS2 (235439_at)RIT1 (239843_at)VAMP4 (211760_s_at)CNTNAP1 (219400_at)SLFN5 (238430_x_at)TMEM30A (222391_at)ADAMTS12 (221421_s_at)BTBD3 (202946_s_at)ZDHHC9 (222451_s_at)KIF3A (228680_at)DST (1553191_at)RAB5A (206113_s_at)MXD4 (212346_s_at)CYSLTR1 (231747_at)GFPT1 (227027_at)RGMB (226989_at)MXD4 (210778_s_at)RNF24 (204668_at)DCTN4 (233490_at)QPRT (204044_at)TBC1D2B (212796_s_at)TSPAN4 (209263_x_at)−−− (224346_at)−−− (224261_at)ANKRD10 (241414_at)−−− (236668_at)AHR (202820_at)CCDC115 (224946_s_at)MAFF (205193_at)ARMCX1 (218694_at)NCOA3 (211352_s_at)−−− (1566950_at)SEC63 (201915_at)TMEM179B (228089_x_at)LOC100134190 /// LRP1 (200785_s_at)UFM1 (222502_s_at)SEMA6D (233882_s_at)CBX6 (202048_s_at)C1orf198 (223063_at)TRPV2 (222855_s_at)DNAJB9 (1554462_a_at)RNF24 (210706_s_at)CCND1 (208711_s_at)YIPF6 (212340_at)DNAJB4 (203811_s_at)IGFBP7 (201163_s_at)NDFIP2 (224802_at)ITPRIPL2 (1568619_s_at)EDEM3 (220926_s_at)ERAP1 (212580_at)APBA2 (209871_s_at)VAMP2 (214792_x_at)GPR177 (228950_s_at)ARHGAP25 (204882_at)−−− (238573_at)PEX11B (202658_at)SP110 (223980_s_at)APRT (203219_s_at)CTSZ (210042_s_at)−−− (237945_at)ATP6V0E1 (201171_at)−−− (225880_at)−−− (235427_at)−−− (227121_at)GDF15 (229868_s_at)ZFAND5 (217741_s_at)TMEM50B (222907_x_at)PBXIP1 (212259_s_at)RHOJ (1555233_at)SGCB (205121_at)VEZT (223675_s_at)FAM155A (214825_at)UBE2B (202333_s_at)SGCD (230730_at)PDCD4 (202731_at)SEPT11 (230071_at)MAF (209348_s_at)−−− (213156_at)ABCC4 (1554918_a_at)TMOD1 (203662_s_at)TP53INP2 (224836_at)SMURF2 (232020_at)TRAM1 (210733_at)YIPF5 (224949_at)EDEM3 (223243_s_at)TM4SF1 (209387_s_at)CTTN (214073_at)SHISA5 (222986_s_at)−−− (216028_at)DPP7 (224814_at)DEDD2 (225434_at)TMEM189 /// UBE2V1 (223186_at)NAAA (215178_x_at)SPTAN1 (214925_s_at)SAMD14 (213866_at)DVL3 (201908_at)EIF5A2 (220198_s_at)RHBDD2 (232053_x_at)BSCL2 (208906_at)−−− (230299_s_at)CD151 (204306_s_at)G6PC3 (221759_at)GUK1 (213621_s_at)LOC100130905 (226526_s_at)ZNF605 (227822_at)FAM71F1 (236214_at)LOC641467 (229990_at)ABCF3 (202394_s_at)−−− (1557521_a_at)PSG3 (203399_x_at)MSX1 (228473_at)TIMP1 (201666_at)LOC728730 (242835_s_at)NCRNA00094 (203245_s_at)−−− (221861_at)FAM43A (227410_at)−−− (231508_s_at)C5orf4 (220751_s_at)CALD1 (212077_at)C3orf38 (1569129_s_at)BMPR2 (231873_at)FN1 (1558199_at)SDF4 (217855_x_at)SIN3B (209352_s_at)ETV1 (221910_at)−−− (1557012_a_at)C14orf45 (220173_at)PCDHB13 (221450_x_at)CALD1 (243084_at)NUCB1 (200649_at)TMEM39A (241392_at)FAM135A (223497_at)MOGS (210627_s_at)PCDH18 (225977_at)JMY (241985_at)C12orf76 (226583_at)NAV1 (224774_s_at)RRBP1 (201203_s_at)HIP1R (38340_at)PABPN1 (213046_at)MAP3K13 (211083_s_at)BCO2 (232449_at)C6orf99 /// LOC100130967 (230487_at)C1orf183 (229608_at)FBXO9 (1559096_x_at)RABGAP1L (203020_at)SFRS11 (213742_at)NSUN5C (213460_x_at)EPS8L2 (218180_s_at)CTSF (203657_s_at)FAM66C /// FAM66D (1559950_at)RILPL1 (1554017_at)SPRYD3 (225134_at)GRINA (212090_at)HYAL3 (211728_s_at)VKORC1 (217949_s_at)GLIS2 (223378_at)LOC284297 (230228_at)SUPT6H (208830_s_at)C19orf66 (218429_s_at)C16orf52 (230296_at)SLC22A15 (228497_at)CBX7 (212914_at)−−− (206659_at)TMEM80 (221951_at)IL15RA (207375_s_at)−−− (232729_at)TBC1D9B (212054_x_at)PPP2R3C (1569894_at)SLC35E1 (235035_at)CASP4 (213596_at)SLC44A2 (224609_at)MGAT4B (220189_s_at)SLC36A1 (1553272_at)KIAA1324 (226248_s_at)LOC644450 (215625_at)PSAP (200871_s_at)TCTN1 (218584_at)PNKD (225298_at)EME2 (1569867_at)NAT9 (204382_at)MASP1 (235770_at)CABYR (219928_s_at)SMAD7 (204790_at)C1QTNF5 /// MFRP (223499_at)C7orf43 (220659_s_at)GOLGA8A /// GOLGA8B (210424_s_at)MAP6D1 (242838_at)TRPS1 (218502_s_at)FLJ35700 (1559277_at)−−− (244247_at)SLC46A1 (1558703_at)UHRF1BP1 (226135_at)FLJ32255 (235291_s_at)SH3BP5 (201810_s_at)PMEPA1 (222449_at)GABBR2 (211679_x_at)CCNL2 (222999_s_at)KIAA1772 (220340_at)FLJ36644 (1558234_at)−−− (230282_at)−−− (238728_at)LAMB2 (216264_s_at)KLC1 (212878_s_at)ARMC9 (219637_at)DTNA (227084_at)ABCC10 (215873_x_at)TOLLIP (233881_s_at)EXPH5 (213929_at)SNAP29 (222597_at)CHMP1B (218178_s_at)TFE3 (206649_s_at)WDR42A (216885_s_at)−−− (1557316_at)HSPA6 (213418_at)ZNF783 (213367_at)PPM1H (233911_s_at)ADD1 (214736_s_at)LOC729970 (230433_at)SH3TC2 (219710_at)APLP2 (214875_x_at)RRBP1 (201206_s_at)LPIN2 (202459_s_at)SLC12A9 (223995_at)ATRX (208860_s_at)SERPINB8 (206034_at)ZNF219 (219314_s_at)SUPT6H (1554311_a_at)−−− (236806_at)XAF1 (206133_at)UBAC2 (224298_s_at)ADRBK2 (204183_s_at)MGC16275 (1558167_a_at)ASL (204608_at)GALNTL4 (1554079_at)WIPI2 (202031_s_at)TRIM38 (203568_s_at)ANK3 (206385_s_at)−−− (240823_at)RAB43 (225632_s_at)MAGI1 (232859_s_at)MKNK1 (209467_s_at)ALS2CL (229887_at)VDR (204254_s_at)PERLD1 (55616_at)NEGR1 (243357_at)TUBG2 (203894_at)KIF13B (202962_at)SURF1 /// VPS37A (204295_at)BRWD1 (1553227_s_at)PLD1 (205203_at)OGFOD2 (219246_s_at)MGC16275 (1558166_at)SORT1 (212807_s_at)IFFO1 (36030_at)C7orf13 (236340_at)LMF1 (46142_at)KIFC2 (226792_s_at)B4GALNT1 (206435_at)ZFP14 (232911_at)ASB6 (221657_s_at)FLJ44342 (229246_at)BBS4 (212745_s_at)DOCK4 (205003_at)CERCAM (227381_at)NADSYN1 (218840_s_at)SC65 (204078_at)ZHX2 (203556_at)SGSM2 (36129_at)PCSK5 (205559_s_at)TBRG1 (226318_at)GDPD3 (219722_s_at)−−− (235902_at)−−− (230640_at)−−− (1557315_a_at)STK36 (231806_s_at)B3GALT6 (1553959_a_at)C15orf17 (224804_s_at)CLU (222043_at)KIAA0652 (203364_s_at)LZTR1 (203412_at)HECA (218603_at)FBXL16 (227641_at)GORASP1 (215749_s_at)−−− (216943_at)FLJ41603 (227717_at)BTN2A2 (205299_s_at)SCRN3 (222849_s_at)−−− (229202_at)PSMG1 (238890_at)ZNF862 (226808_at)RFX5 (202963_at)PYROXD2 (228384_s_at)PER1 (202861_at)−−− (239881_at)−−− (227979_at)LOC283745 (1557627_at)ZNF846 (1569156_at)SLC35F5 (240335_at)LOC286208 (1560089_at)HBP1 (207361_at)BAT1 (212384_at)CSNK1A1 (1556006_s_at)LOC100133005 /// RASA4 (212706_at)−−− (225801_at)SMCR7 (235896_s_at)GATS (1553971_a_at)PITPNA (201191_at)EPHA6 (1561396_at)KCTD13 (221889_at)MAPK10 (204813_at)ProSAPiP1 (204447_at)ELMO2 (221528_s_at)LOC283070 (226959_at)RAB3A (204974_at)SERPINB8 (1554616_at)DTNA (208430_s_at)ORMDL3 (235136_at)−−− (236138_at)−−− (1556153_s_at)SLC20A1 (230494_at)CAMK1D (220246_at)CIDEC (219398_at)MAPK11 (211499_s_at)BBS4 (212744_at)BDH2 (218285_s_at)MCAM (209086_x_at)ABCC10 (213485_s_at)FAR2 (220615_s_at)ADCY9 (204497_at)MEG3 (229557_at)LRRC17 (232924_at)CHIC1 (1559481_at)ZFAND3 (222493_s_at)−−− (242906_at)−−− (240472_at)DUSP4 (204014_at)KLHL9 (233197_at)ARRB1 (222912_at)PPP3CC (32541_at)VWCE (242957_at)RAB3IP (238853_at)−−− (225176_at)PNPLA3 (220675_s_at)C10orf54 (225373_at)SUFU (222749_at)MBTPS2 (206473_at)MAP3K13 (206249_at)KCNMB4 (222857_s_at)HERC4 (232026_at)−−− (1559086_at)CIRBP (225191_at)LOC649851 /// MYL5 (205145_s_at)GSG1 (221252_s_at)ENG (201809_s_at)GLI4 (238364_x_at)PARD6B (214827_at)−−− (230571_at)STX17 (228091_at)FUK (226072_at)PPM1F (203063_at)−−− (243338_at)ANKRD34A (232735_at)ZNF224 (216983_s_at)−−− (237521_x_at)FBXL13 (1556770_a_at)PRLR (206346_at)−−− (1556008_a_at)BICC1 (220580_at)FLJ39739 (1556457_s_at)ERGIC1 (224577_at)KRT34 (206969_at)COQ4 (218328_at)TBC1D13 (218596_at)MTMR3 (202197_at)FYCO1 (1555523_a_at)C9orf25 (225146_at)CLN8 (219341_at)IFIT3 (204747_at)C3orf34 (230860_at)IRF9 (203882_at)CD99L2 (223041_at)−−− (239425_at)ZNF652 (205594_at)−−− (238824_at)ERAP1 (210385_s_at)−−− (229823_at)CNNM2 (1554523_a_at)CCDC69 (212886_at)MAP6 (228943_at)DDX56 (238525_at)BLOC1S3 (228244_at)FAM98A (239487_at)−−− (235771_at)DSTN (230933_at)TUSC2 (203273_s_at)TBXA2R (207554_x_at)−−− (240961_at)OCLN (209925_at)−−− (1561893_at)GOLGA8A (208798_x_at)ST7L (233141_s_at)−−− (228861_at)GALC (211810_s_at)PCNX (235082_at)PLD6 (227037_at)FAM70B (238226_at)C6orf97 (220581_at)LOC153577 (1556750_at)PDE11A (224223_s_at)RNPC3 (229903_x_at)LOC100133666 /// LOC440104 (227106_at)SCAMP1 (1552978_a_at)−−− (232369_at)PDE5A (1556786_at)C1orf145 (1560554_a_at)−−− (228740_at)CLEC4A (219947_at)C14orf182 (239777_at)PREPL (212215_at)VAMP1 (207101_at)APBB2 (40148_at)NDFIP1 (222422_s_at)−−− (229167_at)HCG18 (232975_at)CYP4V2 (228391_at)FBXO2 (219305_x_at)PGPEP1 (1555165_a_at)MEGF10 (236517_at)PBXIP1 (207838_x_at)KIAA0284 (213242_x_at)ATP6V0D2 (1553151_at)−−− (235681_at)CYB5A (215726_s_at)RIT1 (236223_s_at)ANO2 (220111_s_at)LRRC37B2 (216149_at)RAI2 (219440_at)LNPEP (207904_s_at)LOC283484 (1556941_a_at)SLC2A11 (232167_at)SLC35D1 (209713_s_at)NBR1 (1568856_at)MIA3 (212310_at)TSPYL2 (218012_at)CARS (240983_s_at)FAM124A (230067_at)LOC387763 (227099_s_at)SIRPA (202895_s_at)−−− (243532_at)RPL5 /// RPL5P1 /// RPL5P34 /// SNORA66 (210035_s_at)LOC283745 (1557628_s_at)−−− (1568191_at)DDX49 (232915_at)LOC349114 (1558423_at)BC036928 (238708_at)ATP6V1G2 (214762_at)SLC38A7 (218727_at)HLA−G (211529_x_at)FAM63B (214691_x_at)−−− (1562696_at)SHC4 (230538_at)ZNF521 (226676_at)SNAPC1 (205443_at)SOX6 (228214_at)NCOA3 (209062_x_at)RAPGEF2 (215992_s_at)CD44 (217523_at)EDEM3 (220342_x_at)TMTC1 (226931_at)FBXL20 (239223_s_at)−−− (1561187_at)−−− (222098_s_at)SLC38A9 (235241_at)−−− (227126_at)SORBS1 (222513_s_at)FGF9 (239178_at)FLJ27352 (243309_at)C16orf72 (228373_at)ZNF44 (206810_at)TAP2 (208428_at)−−− (1560659_at)−−− (1560071_a_at)ZNF449 (241066_at)LNX1 (223611_s_at)PRL (205445_at)PCBD2 (223712_at)DNAJC5 (224613_s_at)CANX (238034_at)CDR1 (207276_at)−−− (1558626_at)DMD (203881_s_at)LOC729680 (228977_at)−−− (242731_x_at)VPS41 (203106_s_at)−−− (239278_at)KLHL28 (235727_at)ITPKC (213076_at)WNT9A (230643_at)ATG4B (204902_s_at)ZNF271 (211009_s_at)−−− (228151_at)COL4A5 (234387_at)EPAS1 (200879_s_at)NBL1 (201621_at)IP6K2 (223165_s_at)IGFBP5 (211958_at)ITM2C (221004_s_at)MGAT3 (209764_at)−−− (241872_at)QKI (214541_s_at)−−− (228951_at)−−− (201205_at)−−− (240964_at)GABBR1 (238569_at)PGPEP1 (219891_at)−−− (231680_at)SORT1 (212797_at)SCAMP1 (206668_s_at)FKBP14 (235311_at)PNRC1 (209034_at)IGFBP5 (203424_s_at)RFTN2 (238955_at)MDM2 (205386_s_at)MDM2 (225160_x_at)PLXNA3 (1553139_s_at)CHST12 (218927_s_at)−−− (238363_at)PI4KB (206138_s_at)NDST2 (1559701_s_at)RP4−692D3.1 (243036_at)−−− (241617_x_at)STX4 (236232_at)LZTFL1 (218437_s_at)FKRP (219853_at)LOC285835 (230937_at)RUNX3 (204197_s_at)−−− (237384_x_at)MPV17L2 (223473_at)FCHSD2 (203620_s_at)−−− (231302_at)CLIP1 (210716_s_at)PGPEP1 (223469_at)LOC647979 (1558028_x_at)KIAA0562 (204075_s_at)C2orf34 (219617_at)COMMD5 (224387_at)LEPR (209894_at)SPG7 (202104_s_at)RNF141 (226106_at)MAN1B1 (65884_at)DNAJC1 (222621_at)LPCAT2 (222833_at)SGTB (228745_at)TMEM33 (222642_s_at)LTBP2 (223690_at)MRAS (225185_at)MAP2K3 (207667_s_at)CSF2RB (205159_at)ATP6V1G1 (238765_at)TMEM106A (1552302_at)TNFSF18 (221371_at)−−− (239587_at)HIPK3 (210148_at)LATS2 (223380_s_at)GPR63 (220993_s_at)PERP (240797_at)SEMA6A (220454_s_at)−−− (238919_at)ASAH1 (210980_s_at)PLEKHM1 (212717_at)−−− (224989_at)CLN5 (204084_s_at)CLCA2 (206164_at)TRNP1 (227862_at)TMEM38B (218772_x_at)ARHGAP5 (1552627_a_at)TNFSF13B (223502_s_at)MAP1A (215391_at)RNASEK (224573_at)HINT3 (226533_at)HIST3H2A (221582_at)EEA1 (204841_s_at)HOXB8 (229667_s_at)C7orf10 (219655_at)CFLAR (237367_x_at)VAMP2 (201557_at)−−− (228231_at)OBFC2A (222872_x_at)IDS (212223_at)DAB2 (201280_s_at)PDE5A (1562228_s_at)SLC31A2 (204204_at)−−− (228275_at)MAMDC2 (228885_at)LPAR1 (204036_at)SDF2 (203090_at)GNPTAB (212959_s_at)B4GALNT2 (1552903_at)MBNL2 (1553536_at)DNAJC3 (225284_at)STS (203767_s_at)MGST1 (1565162_s_at)LAMP2 (203042_at)MTDH (212248_at)SEC62 (208942_s_at)ARL1 (201658_at)KIAA1632 (232031_s_at)TMEM104 (220097_s_at)ATP8A1 (213106_at)−−− (1557740_a_at)−−− (227503_at)RNF44 (203286_at)TSPAN11 (227610_at)MGST1 (231736_x_at)PPM1H (212686_at)EPB41L1 (222066_at)POFUT2 (209578_s_at)ERAP2 (219759_at)MPZL1 (210594_x_at)OSTalpha (229230_at)NFAT5 (215092_s_at)SLC3A1 (205799_s_at)SLC7A11 (207528_s_at)PTGER4 (204897_at)ERMP1 (218342_s_at)C6orf89 (224988_at)SLC39A9 (222445_at)BSDC1 (218004_at)KIAA0319L (222468_at)TMCO1 (208715_at)SLC33A1 (1554148_a_at)C12orf59 (236646_at)CTSC (201487_at)FAT4 (219427_at)IDS (206342_x_at)EDN1 (222802_at)COQ10B (219397_at)SLC7A11 (217678_at)FAM73A (235125_x_at)LOC728730 (242313_at)−−− (226742_at)EPHA4 (227449_at)AHRR (229354_at)TMCC1 (227112_at)DSEL (232235_at)RASA1 (202677_at)TNPO1 (212635_at)PEX7 (205420_at)CLN8 (219340_s_at)SGSH (35626_at)ZDHHC21 (243550_at)SIDT2 (56256_at)TMCO1 (211098_x_at)LOC202451 (236037_at)RAPH1 (225186_at)NDFIP2 (224801_at)LOC401577 (232172_at)−−− (227591_at)−−− (239396_at)−−− (241721_at)CDKL3 (241911_at)GABBR2 (209990_s_at)SLC9A1 (209453_at)CHKB /// CPT1B (210069_at)POLR2B (1555836_at)PIGV (219238_at)KLHL24 (242088_at)PIGV (51146_at)ABCC6 (214033_at)C17orf28 (244593_at)RABIF (204477_at)TBC1D2 (222173_s_at)PLEKHA6 (229245_at)TMED4 (1558487_a_at)−−− (1561432_at)−−− (1568781_at)PVRL3 (213325_at)RNF11 (208924_at)XIAP (228363_at)−−− (226873_at)VASN (225867_at)LOC100130536 (230054_at)KCNJ15 (211806_s_at)ARHGAP24 (221030_s_at)LOC100128661 (230293_at)TMEM68 (226483_at)YIPF6 (212343_at)BMPER (241986_at)C2orf64 (225409_at)−−− (1560285_at)PLAA (235394_at)DACH1 (205471_s_at)PCMTD2 (212406_s_at)ACAP2 (212476_at)ANKRA2 (218769_s_at)GOSR2 (213206_at)RIT1 (243463_s_at)TMEM128 (225462_at)ASPH (225008_at)SCAMP1 (206667_s_at)PURG (220860_at)ZDBF2 (228749_at)−−− (228726_at)WDR44 (219297_at)WDR26 (224898_at)ZFAND5 (210275_s_at)TPP1 (200743_s_at)C18orf32 (224957_at)−−− (241745_at)DDX58 (242961_x_at)UBE2H (221962_s_at)WDR51B (226283_at)HIPK2 (225368_at)DEGS1 (209250_at)SLC37A3 (223304_at)FLJ40113 /// LOC440295 (213212_x_at)C19orf12 (227704_at)MAN1C1 (218918_at)−−− (215514_at)C10orf125 (230259_at)CLN8 (229958_at)BNIP2 (226280_at)MSX2 (210319_x_at)FGF7 (205782_at)PTPN13 (204201_s_at)−−− (227052_at)USP53 (231817_at)TXNDC15 (227873_at)PLA2G12A (228084_at)KLHL24 (226158_at)SH3RF1 (225589_at)TOR1AIP1 (216100_s_at)C5orf46 (1554195_a_at)EEA1 (225885_at)PAM (214620_x_at)TFPI (210665_at)−−− (222249_at)PLK3 (204958_at)SCAMP2 (224921_at)POMP (222402_at)CPEB2 (235462_at)TOM1L2 (214840_at)C13orf31 (228937_at)ZDHHC21 (229240_at)BLZF1 (203840_at)STAM2 (228254_at)ARAF (230652_at)FLJ43080 (1568698_at)CBFA2T2 (207625_s_at)AP3S2 (202398_at)ZNF720 (238510_at)ZNF521 (226677_at)−−− (232853_at)NEDD9 (202149_at)PLD1 (226636_at)GORASP2 (208843_s_at)ZCWPW2 (243863_at)YIPF4 (209551_at)ANK2 (202920_at)−−− (242606_at)ACSL1 (201963_at)AIG1 (223136_at)ACBD5 (225663_at)STXBP3 (203310_at)UBR3 (230029_x_at)DMXL1 (203791_at)LYSMD1 (232283_at)GOSR2 (243880_at)−−− (241858_at)ZNF641 (226509_at)GOLGA9P (213737_x_at)RIPK2 (209544_at)−−− (239117_at)−−− (240467_at)KLHDC1 (1552733_at)LOC644242 (1558404_at)C10orf118 (227701_at)CD4 (203547_at)−−− (1568807_a_at)−−− (1557400_at)GAD1 (205278_at)CXCL1 (204470_at)CASK (227156_at)ATP7B (204624_at)−−− (230277_at)ELMO1 (204513_s_at)FMNL3 (238823_at)ELMO2 (55692_at)TSLP (235737_at)GALNTL2 (236361_at)KLF4 (221841_s_at)FGF11 (227271_at)RAB3D (225001_at)CYB561 (207986_x_at)PDLIM4 (214174_s_at)AREG (205239_at)TAPBPL (218747_s_at)CADM1 (209031_at)NFKBIZ (223218_s_at)RORA (236266_at)SOX4 (201417_at)PAMR1 (213661_at)ITGB5 (201124_at)SPON2 (218638_s_at)JMY (226352_at)TGM2 (201042_at)TCP11L2 (1553861_at)ERN1 (207061_at)C13orf15 (218723_s_at)C13orf15 (228193_s_at)SESN2 (223196_s_at)OBFC1 (228781_at)WDR26 (224897_at)LNPEP (231866_at)RAB3GAP1 (213530_at)ARL1 (201657_at)TEK (206702_at)BEX4 (215440_s_at)PROCR (203650_at)ATRX (208861_s_at)TMEM176A (218345_at)PVR (214443_at)CCNG2 (202769_at)CXADRP1 (239155_at)TMEM87B (225411_at)FLJ23867 /// QSOX1 (226706_at)C10orf54 (225372_at)−−− (228444_at)PTGS1 (205128_x_at)PTGS1 (215813_s_at)NAV1 (224771_at)CADM1 (209032_s_at)ZNF555 (239839_at)GALNTL2 (228501_at)WDR26 (224905_at)HSD17B2 (204818_at)EPAS1 (200878_at)SAT1 (203455_s_at)SGCD (210329_s_at)SLC16A4 (205234_at)PTGS1 (238669_at)GABARAPL1 (208868_s_at)NAV1 (224772_at)HLA−B (209140_x_at)GABARAPL1 /// GABARAPL3 (211458_s_at)ITGB5 (201125_s_at)C1S (208747_s_at)CFH /// CFHR1 (215388_s_at)FRY (204072_s_at)PAPPA (224941_at)PAPPA (228128_x_at)KIAA1462 (213316_at)−−− (229319_at)SLC11A2 (210047_at)IL8 (202859_x_at)HLA−C (214459_x_at)HLA−C (208812_x_at)ITGB5 (214021_x_at)LAMP2 (203041_s_at)PRDX6 (200845_s_at)KIAA1462 (231842_at)WIPI1 (213836_s_at)LUM (201744_s_at)TNFRSF11B (204932_at)PDE5A (227088_at)ARMCX3 (222444_at)SGCD (228602_at)PLEKHA1 (226247_at)SCAMP1 (212416_at)SEC62 (1552789_at)TMEM66 (200847_s_at)TSPAN31 (203227_s_at)FAM155A (230869_at)YIPF5 (224953_at)−−− (227095_at)NCOA3 (207700_s_at)ABCC4 (203196_at)PCMTD1 (232382_s_at)MAN2A1 (226538_at)PLSCR4 (218901_at)SAT1 (210592_s_at)NFE2L3 (236471_at)KDSR (229850_at)PAM (202336_s_at)PDHX (203067_at)FILIP1L (204135_at)HBD (206834_at)ITM2B (217732_s_at)FHL1 (201540_at)PAPPA (201981_at)SVIL (202565_s_at)FAM18B (218446_s_at)SQRDL (217995_at)SGCD (213543_at)C21orf7 (221211_s_at)DUSP22 (218845_at)SLITRK6 (235976_at)HBB (209116_x_at)RGS18 (223809_at)PLXDC2 (227276_at)IGDCC4 (227870_at)SLC2A10 (221024_s_at)GCLC (202922_at)PDGFRA (203131_at)GCLC (202923_s_at)ITGB5 (214020_x_at)SPARC (212667_at)CYB5R3 (201885_s_at)LRRC17 (205381_at)COL4A5 (213110_s_at)LRCH2 (227688_at)C5orf4 (48031_r_at)IFITM1 (214022_s_at)COG6 (225769_at)NUMB (207545_s_at)WWTR1 (202133_at)PGRMC2 (213227_at)HLA−C (216526_x_at)PCMTD1 (226119_at)SUMF1 (226850_at)PELO (226731_at)VEZT (223090_x_at)FGF7 /// KGFLP1 /// KGFLP2 (1554741_s_at)NEGR1 (229461_x_at)KIAA1191 (224502_s_at)BRWD1 (219280_at)SH3PXD2A (207661_s_at)SOD2 (216841_s_at)−−− (240050_s_at)RHOQ (212122_at)SGCB (228584_at)SH3PXD2A (213252_at)HLA−F (221875_x_at)PTGS1 (205127_at)MFAP4 (212713_at)PRAF2 (203456_at)−−− (232125_at)ZNF652 (225266_at)CTAGE5 (215930_s_at)−−− (229123_at)PTPRG (204944_at)PIK3CA (235980_at)TRIB2 (202478_at)GGPS1 (202321_at)NAV1 (224773_at)SOD2 (215223_s_at)ARL8A (225347_at)B2M (216231_s_at)−−− (227191_at)BMPR2 (225144_at)FAM73A (243042_at)FNDC3B (222692_s_at)FKBP14 (219390_at)MAN2A1 (235103_at)DNAJB4 (203810_at)SERINC1 (208671_at)MICB (206247_at)ATF6 (231927_at)PNPLA8 (223310_x_at)EVI5 (209717_at)−−− (222111_at)C7orf58 (228728_at)EIF2AK3 (218696_at)VPS37A (228024_at)SEC22B (209206_at)RNF13 (201780_s_at)FNDC3B (222693_at)ITM2B (217731_s_at)CASC4 (224619_at)KCTD12 (212192_at)TBC1D8B (219771_at)RECK (205407_at)EFEMP1 (201842_s_at)PMAIP1 (204286_s_at)NAP5 (239650_at)SLC25A46 (226831_at)−−− (230383_x_at)MYO6 (203216_s_at)ATP6V0C (200954_at)APP (214953_s_at)KCTD12 (212188_at)NTM (227566_at)PDE5A (206757_at)PCDH18 (225975_at)MXRA7 (227326_at)KIAA1462 (231841_s_at)MAFF (36711_at)GFPT1 (202722_s_at)OSTC (223001_at)ITGA11 (222899_at)MYLIP (223130_s_at)AHSA2 (226665_at)−−− (238658_at)RFTN2 (241698_at)GBP2 (202748_at)MAGED2 (213627_at)LOC149478 (1557049_at)JHDM1D (221778_at)ATXN1 (203231_s_at)PDLIM4 (214175_x_at)DNASE1 (243127_x_at)CHMP1B (218177_at)MEG3 (235077_at)GNAL (214071_at)MLANA (206426_at)LPHN3 (209867_s_at)NTNG2 (233072_at)FCGRT (218831_s_at)−−− (234240_at)−−− (235279_at)TMEM120B (219154_at)CAMK2G (212669_at)TMEM219 (224981_at)YIPF6 (212341_at)BMP4 (211518_s_at)−−− (236798_at)IGF2R (201393_s_at)TIMP3 (201147_s_at)MPZL1 (201875_s_at)NISCH (201591_s_at)MCTP2 (229005_at)SGCD (210330_at)HIAT1 (225222_at)PRKAB2 (225278_at)TRPA1 (208349_at)LOC283904 (242332_at)COMT (208818_s_at)MGP (202291_s_at)TAGLN (226523_at)CCDC50 (228693_at)−−− (1565602_at)LIMA1 (222456_s_at)HLA−E (217456_x_at)USP53 (230083_at)PGM2L1 (238417_at)HIP1R (209558_s_at)SORT1 (224818_at)−−− (216565_x_at)HM13 (232209_x_at)HLA−C (211799_x_at)−−− (241260_at)IGFBP5 (203425_s_at)PGPEP1 (237202_at)HLA−B (211911_x_at)−−− (241359_at)−−− (238709_at)SLITRK6 (232481_s_at)NADSYN1 (232946_s_at)HLA−B (208729_x_at)LOC283788 (229187_at)RORA (235567_at)IRGQ (239177_at)−−− (238455_at)PCSK5 (205560_at)PLEKHO2 (204436_at)RGS5 (218353_at)TCP11L2 (1565525_a_at)ITPR1 (211323_s_at)FLJ35776 (238432_at)FRY (214319_at)NRXN1 (209915_s_at)−−− (242481_at)VAMP1 (207100_s_at)LOC642852 (226995_at)C17orf57 (1553626_a_at)ZNF652 (235577_at)−−− (237337_at)TRPS1 (222651_s_at)GGT1 (209919_x_at)KIAA0415 (209912_s_at)−−− (225221_at)LRRC57 (229232_at)TBC1D8B (238067_at)MGST2 (204168_at)MAN1A1 (221760_at)TMEM116 (227172_at)APOL6 (1557236_at)KIAA1109 (212779_at)SYNE1 (244144_at)GSTM1 (204550_x_at)GMIP (218913_s_at)C22orf9 (227144_at)GPR155 (244509_at)TMEM35 (219685_at)GSTA4 (202967_at)SIN3B (39705_at)OSTM1 (235197_s_at)QKI (212636_at)PID1 (219093_at)SLC18A2 (205857_at)LAMA5 (210150_s_at)−−− (238598_s_at)CCDC3 (223316_at)GK (214681_at)VCPIP1 (1556227_at)VEZT (223089_at)UBR2 (212760_at)NEDD9 (202150_s_at)MAN1A1 (208116_s_at)SH3BGRL2 (225354_s_at)ARHGAP6 (206167_s_at)ARMCX2 (203404_at)GOLGB1 (201056_at)ANXA4 (201301_s_at)FLJ33996 /// LOC100127971 (244708_at)C5orf4 (48030_i_at)VPS13B (236254_at)TM2D1 (213882_at)GOSR2 (213207_s_at)IQSEC1 (203906_at)GOLGA2 (225672_at)ANXA4 (201302_at)AK3 (224655_at)TM7SF3 (226478_at)ANTXR1 (224694_at)IFNGR1 (202727_s_at)MITF (226066_at)SGCB (226112_at)SH3YL1 (204019_s_at)STC2 (203438_at)SEL1L (202061_s_at)KDSR (1558279_a_at)HBP1 (209102_s_at)GALNT1 (201722_s_at)−−− (238115_at)LRRC37A2 (224686_x_at)SLC35D2 (233325_at)HEBP1 (218450_at)ALAD (218487_at)MANBA (203778_at)CPEB2 (226939_at)LPIN2 (202460_s_at)ARHGEF9 (203264_s_at)MTSS1 (203037_s_at)MANSC1 (220945_x_at)CDK6 (224848_at)VPS13B (213243_at)MTHFSD (230442_at)PPP3CC (207000_s_at)MAFB (218559_s_at)NCRNA00158 (231303_at)CYTSB (228900_at)SESN1 (218346_s_at)CSAD (1568620_at)FAM82A1 (1560042_at)GSDMB (219233_s_at)MTHFR (239035_at)NECAP2 (230123_at)DENND2C (230769_at)KRT33B (207787_at)ALS2CR8 (219834_at)GIPC2 (219970_at)ARL6 (223735_at)C3orf23 (241666_at)−−− (232029_at)RAPGEF2 (203096_s_at)−−− (1557835_at)−−− (1565732_at)C1orf101 (240771_at)−−− (228799_at)SPON1 (213994_s_at)C14orf101 (219757_s_at)OCRL (203446_s_at)WASL (224813_at)ELL3 (219517_at)ANKRD13C (238597_at)−−− (230744_at)ZNF264 (230063_at)−−− (239690_at)LACTB2 (218701_at)ANKH (223093_at)STAU2 (227179_at)DAB2 (232898_at)RMND5A (212482_at)KIAA0182 (212056_at)CLCN5 (226274_at)MSI2 (243010_at)SLC29A3 (219344_at)−−− (228724_at)SATB2 (213435_at)TTC18 (229170_s_at)MCCC1 (218440_at)−−− (222352_at)DAAM1 (216060_s_at)DTNA (210736_x_at)LUZP2 (215323_at)PIGM (235532_at)DNAJC28 (220372_at)NUDT7 (228855_at)−−− (235659_at)CBLN3 (235221_at)FBXO44 (223517_at)−−− (235386_at)IL20RB (228575_at)LOC375010 (1566147_a_at)ST7L (219964_at)PIGL (232262_at)MYO6 (203215_s_at)SLC9A7 (214860_at)CCDC14 (240884_at)B4GALNT1 (1555385_at)C1orf71 (225551_at)CYP4V2 (226745_at)−−− (236211_at)MOSPD2 (221895_at)DNAJC3 (1558080_s_at)ST7L (1552739_s_at)AIG1 (230520_at)WHAMM (228953_at)SCN4B (236359_at)C6orf35 (218453_s_at)ATP6AP2 (201442_s_at)GMPR (204187_at)DKK3 (230508_at)−−− (237022_at)SCRN3 (1555595_at)WDR66 (1555006_at)SYNE1 (232027_at)MTDH (227277_at)KIAA1737 (225623_at)LOC652900 /// SEZ6L2 (233337_s_at)USP46 (203869_at)POLH (231115_at)CPD (201943_s_at)MBNL2 (205018_s_at)FBXO22 (225734_at)ERCC6 (207347_at)LOC285550 (227270_at)FLRT3 (219250_s_at)PHF23 (223081_at)TIPARP (212665_at)FBXO15 (231472_at)PNPLA8 (223309_x_at)RC3H2 (231716_at)KCNJ6 (210454_s_at)NAP1L5 (228062_at)−−− (229988_at)LOC643783 (235667_at)DUSP4 (204015_s_at)TLR1 (210176_at)C8orf44 /// SGK3 (220038_at)CPM (235019_at)CCDC90B (222577_at)HSPG2 (201655_s_at)IVD (216958_s_at)UQCC (229672_at)DPY19L2 (230158_at)−−− (242140_at)MR1 (207565_s_at)ZNF805 (238436_s_at)SH3BP5L (223265_at)CMIP (224991_at)MON1A (224500_s_at)RBKS (57540_at)TNFRSF4 (208023_at)−−− (231964_at)GFM1 (225158_at)HEATR5B (233642_s_at)CYCS (229415_at)HCCS (203745_at)C16orf52 (230721_at)FBXO9 (1566507_a_at)GFM2 (225392_at)FLJ45445 /// LOC100128460 /// LOC100133177 /// LOC441124 /// LOC729021 /// LOC729218 /// LOC729660 /// LOC730235 /// tcag7.907 (231821_x_at)EREG (205767_at)−−− (236503_at)PPAPDC1B (223568_s_at)ANKRD13C (1554471_a_at)MOSPD2 (64883_at)C6orf174 /// KIAA0408 (233050_at)−−− (227009_at)C10orf47 (230051_at)−−− (232186_at)−−− (231192_at)GARNL1 (213049_at)CDS2 (212862_at)UACA (1558356_at)TMEM56 (234980_at)PTAR1 (235484_at)−−− (1562079_at)CLCN5 (232127_at)FBXO6 (231769_at)DNASE1 (240144_at)MINK1 (214625_s_at)−−− (237075_at)PLXNA2 (207290_at)BAHD1 (203051_at)LOC440296 (244498_x_at)GNL1 (238487_at)ZNF211 (205437_at)HIST1H4H (208181_at)ANKH (229176_at)FAIM3 (221601_s_at)−−− (243855_at)−−− (1559788_at)COL4A3BP (219625_s_at)SSH2 (1554114_s_at)NDUFB2 (240391_at)DYNC1H1 (244768_at)RPRD1A (222559_s_at)C19orf12 (225863_s_at)PCDHB15 (231789_at)NCRNA00171 (215985_at)MGEA5 (214972_at)IFNAR1 (204191_at)SELPLG (209879_at)MEG3 (231529_at)−−− (238608_at)UBE2Z (236107_at)RTN2 (204217_s_at)LOC100129592 (228803_at)CSAD (238764_at)−−− (229321_s_at)−−− (243599_at)PLAA (209532_at)RABGAP1L (215342_s_at)CCDC69 (1553102_a_at)−−− (238495_at)COL4A3BP (223466_x_at)SLC6A13 (237058_x_at)−−− (1568852_x_at)SRPR (200917_s_at)LOC554202 (1554097_a_at)IDUA (205059_s_at)GPR172A (222155_s_at)C18orf8 (232345_at)RGS5 (209070_s_at)TGFA (205016_at)PRLR (216638_s_at)RBMS2 (205228_at)−−− (1565735_at)LDLR (217183_at)CYB5R3 (1554574_a_at)C19orf6 (213986_s_at)TPP1 (214196_s_at)−−− (217490_at)−−− (216062_at)CASK (207620_s_at)−−− (243271_at)ARID5B (241969_at)IFI27L2 (223626_x_at)MALAT1 (224568_x_at)NRG1 (208241_at)RGS5 (209071_s_at)SESN2 (223195_s_at)NETO1 (1552736_a_at)LOC285033 (235584_at)DSEL (244852_at)NIPAL3 (225875_s_at)NLRP1 (218380_at)CCDC80 (243864_at)−−− (237753_at)ATP2B4 (212135_s_at)C9orf5 (223007_s_at)EPHB2 (209588_at)SLC39A13 (1552295_a_at)AK1 (202587_s_at)P4HTM (222125_s_at)−−− (237372_at)KIAA1539 (211433_x_at)CD44 (1565868_at)MICA /// MICB (205905_s_at)LOC645722 (1555216_a_at)LPAR1 (204038_s_at)SLC9A7 (1552671_a_at)GLS (203157_s_at)COBLL1 (203641_s_at)−−− (227953_at)−−− (226579_at)NDFIP2 (224799_at)SGMS2 (243141_at)PSG3 (215821_x_at)CSGALNACT2 (239077_at)SERPINB2 (204614_at)SERPINE1 (202627_s_at)LPCAT2 (239598_s_at)CTSC (231234_at)ACRC (238825_at)C15orf24 (227535_at)ATP2B4 (205410_s_at)SCOC (223341_s_at)CRY2 (212695_at)CD44 (204489_s_at)DYNC1H1 (229042_s_at)DDA1 (218260_at)YIPF5 (221423_s_at)SEPT8 (209000_s_at)TOB1 (228834_at)ZMYM5 (206652_at)COPZ2 (235897_at)−−− (228315_at)WNT16 (221113_s_at)−−− (213821_s_at)GSTM1 (215333_x_at)NEO1 (225270_at)UCHL1 (201387_s_at)CSGLCA−T (221799_at)LEPROT (202378_s_at)CD46 (211574_s_at)CCND3 (201700_at)SERINC3 (221473_x_at)SEL1L (202064_s_at)TMEM50B (219600_s_at)CACNA2D1 (207050_at)ATF6 (203952_at)LYST (215415_s_at)MYO6 (210480_s_at)RNF121 (219021_at)NIPAL3 (214579_at)−−− (244561_at)CLCN3 (201732_s_at)ATP6V1A (201971_s_at)PDCD1LG2 (220049_s_at)ODZ1 (1553007_a_at)CFLAR (211317_s_at)C20orf194 (225825_at)EIF4G3 (1554310_a_at)−−− (217409_at)COL13A1 (211809_x_at)CXXC5 (233955_x_at)−−− (240032_at)RIMBP3 /// RIMBP3B /// RIMBP3C (230062_at)CCDC85A (235228_at)PNPLA6 (203718_at)TOR1A (202348_s_at)RRAGC (218088_s_at)CTSC (225647_s_at)DIO2 (203700_s_at)AMFR (202204_s_at)SLC16A14 (238029_s_at)NCDN (209556_at)TRIM23 (210995_s_at)STAT1 (AFFX−HUMISGF3A/M97935_MA_at)TMEM150 (226239_at)ANXA9 (211712_s_at)FZD4 (224337_s_at)TMEM117 (223594_at)OCIAD1 (223010_s_at)AKR1C1 (216594_x_at)C6orf89 (225729_at)ZFYVE27 (225218_at)MTMR3 (226956_at)CES2 (213509_x_at)CFLAR (210564_x_at)SLC30A4 (207362_at)−−− (213818_x_at)DST (212253_x_at)CAMK2G (212757_s_at)GM2A (212737_at)CHIC2 (219492_at)FADS3 (204257_at)TPM2 (212654_at)AK5 (219308_s_at)DAG1 (205417_s_at)HGSNAT (222491_at)HIPK2 (225116_at)C6orf72 (225576_at)BDNF (206382_s_at)TTC14 (225178_at)ETV5 (216375_s_at)FNDC3B (218618_s_at)TACC1 (1554690_a_at)IFNGR1 (211676_s_at)AKIRIN1 (222459_at)TBC1D16 (228488_at)DIRC2 (229213_at)IGF2R (201392_s_at)TMED4 (224680_at)DHCR7 (201790_s_at)TOR1AIP2 (240700_at)LOC401074 (1559827_at)DCTN1 (211780_x_at)FRS2 (221308_at)DNAJC5 (224612_s_at)CAT (211922_s_at)AHCYL2 (212814_at)TOLLIP (222469_s_at)−−− (1565677_at)ROGDI (218394_at)ADCK1 (227482_at)APC (203527_s_at)MFAP5 (209758_s_at)GBF1 (201439_at)PALMD (222725_s_at)CLPTM1L (223020_at)NRCAM (204105_s_at)PI4KA (207081_s_at)PPM1F (37384_at)MRPS25 (224015_s_at)C19orf6 (225247_at)−−− (214863_at)ARMC8 (203487_s_at)EPHB2 (210651_s_at)TRNP1 (236052_at)GCNT4 (220831_at)MFGE8 (1558960_a_at)TMEM129 (225587_at)WNT5B (221029_s_at)MAP1A (215384_s_at)MACF1 (215222_x_at)RAB30 (228003_at)−−− (238978_at)DCBLD1 (1553768_a_at)−−− (225345_s_at)−−− (203326_x_at)LOC653110 (1557094_at)C19orf6 (212574_x_at)ANK1 (205391_x_at)MSX1 (205932_s_at)SYPL2 (230611_at)CLPTM1 (211136_s_at)PI4K2A (209346_s_at)TK2 (204277_s_at)SEL1L (202062_s_at)−−− (227473_at)PNPO (218511_s_at)THRB (228716_at)ATP6V0B (200078_s_at)HIGD1A (242317_at)CMTM6 (217947_at)SYNJ1 (207594_s_at)ZNF804A (215767_at)KIAA1632 (234048_s_at)COPS7A (209029_at)RBMS2 (34187_at)HMGCR (202539_s_at)C9orf44 (235776_x_at)−−− (230397_at)LRP12 (220254_at)C1orf204 (1556633_at)C3orf23 (226688_at)C16orf72 (1568954_s_at)SLC39A7 (202667_s_at)FTL (212788_x_at)SEPW1 (201194_at)SNRPN /// SNURF (206042_x_at)AGPAT1 (215535_s_at)SOX6 (223865_at)CYB561 (217200_x_at)GATA3 (209602_s_at)THBS3 (209561_at)WBP1 (223072_s_at)CLIP3 (235243_at)GRN (200678_x_at)TIMP3 (201149_s_at)DLG4 (210684_s_at)RHOJ (238906_s_at)MRVI1 (230214_at)PCDH1 (203918_at)DUSP10 (215501_s_at)IL6R (205945_at)GPR172A (218151_x_at)DNAJC3 (235341_at)PDPK1 (221244_s_at)PAPSS2 (203059_s_at)SLC38A10 (212890_at)COL24A1 (238732_at)−−− (225567_at)DUSP3 (201537_s_at)KCTD4 (240512_x_at)ARSK (239147_at)AKIRIN1 (217893_s_at)REEP3 (235016_at)EVC (219432_at)SLFN5 (1557078_at)SLFN5 (243999_at)ANKRD10 (218093_s_at)ABAT (209460_at)TMEM17 (1557137_at)HMGCS1 (205822_s_at)RPS6KL1 (223534_s_at)IFI27 (202411_at)SRXN1 (225252_at)MDM2 (217373_x_at)HERC4 (225989_at)DIO2 (210819_x_at)GEMIN8 (222854_s_at)TRIM41 (226445_s_at)EXOC7 (214802_at)TM4SF18 (230061_at)HCG11 (1557169_x_at)IL6ST (204864_s_at)C2CD2L (204757_s_at)−−− (243186_at)RPS6KA6 (220737_at)RAB30 (206530_at)ACSL5 (222592_s_at)ATRN (211852_s_at)−−− (1563629_a_at)−−− (230578_at)NDUFV3 (226616_s_at)MARK4 (221560_at)DENND5B (228551_at)NFE2L1 (214179_s_at)SPESP1 (229352_at)PLA2G15 (204458_at)KCTD7 (213474_at)DNAJC30 (223367_at)SGPP1 (221268_s_at)C9orf16 (41047_at)CLTB (221996_s_at)VPS53 (221707_s_at)CLCC1 (1555543_a_at)−−− (1559535_s_at)TRAK1 (214924_s_at)RTKN (225150_s_at)ARSG (1552632_a_at)LDLRAP1 (221790_s_at)PEX10 (206352_s_at)RASGRF2 (1556128_a_at)RGS11 (1554643_at)MAPK12 (1556341_s_at)PLXNB2 (208890_s_at)LIMK2 (210582_s_at)GM2A (35820_at)FAM40A (225226_at)LRP6 (205606_at)HCFC2 (219484_at)ZNF251 (226754_at)TMEM110 (213851_at)DIO2 (231240_at)ALDH1A1 (212224_at)HIPK3 (213697_at)−−− (233820_at)−−− (223930_at)TSPAN12 (230626_at)EXOC2 (219349_s_at)ABHD14A (210006_at)LOC100129899 (238771_at)−−− (236437_at)KTELC1 (218587_s_at)DST (232098_at)EZH1 (203249_at)WIPI2 (204710_s_at)PCDHB7 (231738_at)YPEL2 (229060_at)LETMD1 (207170_s_at)−−− (232600_at)TBX5 (211886_s_at)IRF1 (202531_at)DOPEY1 (213271_s_at)PCNX (238792_at)PCSK7 (203118_at)C10orf110 (220703_at)SSX2IP (203017_s_at)PAFAH2 (205233_s_at)PRDM1 (235668_at)LOC158960 (1558685_a_at)TBX2 (221977_at)CDK7 (211297_s_at)SLC6A15 (239352_at)SCFD2 (236834_at)MTCH2 (222403_at)PSPC1 (218371_s_at)−−− (239069_s_at)C9orf44 (233524_at)−−− (229786_at)GRAMD4 (212856_at)CYLD (39582_at)−−− (242667_at)C12orf73 (226927_at)−−− (230606_at)RHBDD1 (226945_at)FLJ44342 (226419_s_at)DNAJC1 (218409_s_at)PLGLB1 /// PLGLB2 (214415_at)STAT1 (AFFX−HUMISGF3A/M97935_5_at)GFRA1 (227550_at)SNX11 (53912_at)LOC729570 (227837_at)LRCH3 (235347_at)VPS41 (210849_s_at)CLK4 (228751_at)LOC375190 (230435_at)WDR66 (1555007_s_at)TK2 (240300_at)−−− (229572_at)PTGFR (1555097_a_at)KIAA1618 (231956_at)KAT2B (203845_at)MAN2A2 (202032_s_at)TRAK1 (226013_at)STRADA (52169_at)KIF3B (203943_at)PIN4 (204572_s_at)FAM46A (224973_at)−−− (235696_at)−−− (230300_at)SYNE1 (244070_at)ANGEL1 (36865_at)−−− (239669_at)RHBDD2 (222995_s_at)LOC284454 (1555847_a_at)MINK1 (215909_x_at)LOC572558 (230595_at)ARSD (230131_x_at)TMED5 (239283_at)C9orf6 (218998_at)−−− (233928_at)TRPC6 (217287_s_at)IDE (217496_s_at)GREM2 (235504_at)SPIN3 (1555882_at)NAV3 (1562234_a_at)ADPGK (224455_s_at)ZER1 (230358_at)ELMO2 (220363_s_at)H2AFJ (228213_at)DCBLD1 (226609_at)−−− (238155_at)−−− (1556188_a_at)FDPS (201275_at)TM9SF4 (212198_s_at)LRP8 (208433_s_at)EIF4G3 (201935_s_at)−−− (235534_at)−−− (228528_at)RILPL1 (226207_at)DAAM1 (226666_at)−−− (231640_at)RNF13 (201779_s_at)ACSS2 (234312_s_at)AKR1C2 (209699_x_at)PFKFB2 (226733_at)GLRB (205279_s_at)ZNF419 (219826_at)PRKCE (226101_at)TRIB2 (202479_s_at)MORN4 (228354_at)LOC222070 (51774_s_at)BDNF (239367_at)C5orf41 (238476_at)EXOC7 (212034_s_at)DYNC2LI1 (203762_s_at)LAMA3 (203726_s_at)PCYOX1L (218953_s_at)ADRBK2 (228771_at)PCDHA1 /// PCDHA10 /// PCDHA11 /// PCDHA12 /// PCDHA13 /// PCDHA2 /// PCDHA3 /// PCDHA4 /// PCDHA5 /// PCDHA6 /// PCDHA7 /// PCDHA8 /// PCDHA9 /// PCDHAC1 /// PCDHAC2 (223435_s_at)HDAC9 (1552760_at)LOC646014 (238715_at)CFLAR (214486_x_at)LOC285147 (242852_at)CYP2S1 (223385_at)LOC100131564 (227074_at)PRUNE2 (212806_at)TXNDC15 (220495_s_at)DKK3 (221126_at)RGNEF (219610_at)HLA−DMA (217478_s_at)CLU (208791_at)DISP2 (229579_s_at)PION (213142_x_at)PKLR (222078_at)−−− (240083_at)CES2 (209668_x_at)CTSA (200661_at)LPHN3 (209866_s_at)ATRNL1 (1569796_s_at)C7orf58 (220032_at)−−− (240956_at)FLRT3 (222853_at)MAPRE3 (214270_s_at)−−− (228390_at)C1orf182 (230608_at)C17orf71 (218514_at)SEC63 (201914_s_at)CXCL14 (222484_s_at)SATB1 (203408_s_at)STIM2 (225246_at)TBXAS1 (208130_s_at)UBE2H (217799_x_at)SESN3 (235684_s_at)BMPR2 (209920_at)AKR1C2 (211653_x_at)TBC1D19 (220260_at)TMEM181 (225127_at)STEAP3 (1554830_a_at)GPR157 (227970_at)MCAM (210869_s_at)CSNK1E (226858_at)KLHDC10 (209256_s_at)SPTAN1 (208611_s_at)PTGFR (207177_at)FLJ23569 (232462_s_at)ZNF497 (230857_s_at)LRP10 (231861_at)GPR68 (229055_at)BTBD9 (234682_at)SESN3 (235683_at)ADCK2 (44120_at)−−− (229006_at)ZFC3H1 (213065_at)ADAMTSL4 (226071_at)UBR4 (211950_at)FOXC1 (213260_at)ADAMTS9 (226814_at)LOC285550 (236321_at)−−− (237627_at)CYB561D1 (227981_at)APH1B (221036_s_at)AKIRIN1 (222458_s_at)GLA (214430_at)C19orf18 (236847_at)−−− (229798_s_at)−−− (235928_at)MAP2 (225540_at)BEX5 (229963_at)ADAM12 (204943_at)SP110 (208392_x_at)DTNA (210091_s_at)−−− (234340_at)C13orf31 (1553141_at)PAG1 (227354_at)EFHC1 (225656_at)−−− (243462_s_at)−−− (1556048_at)RRAGB (205540_s_at)BCL2L13 (226798_at)SH3RF2 (243582_at)AMY2B (228023_x_at)OAZ3 (222075_s_at)SKIL (217591_at)ZNF136 (206240_s_at)XK (206698_at)−−− (1555854_at)−−− (239793_at)−−− (233364_s_at)ORAOV1 (243531_at)FKBP1B (206857_s_at)CBARA1 (216903_s_at)SNORD114−3 (232355_at)ZNF767 (219627_at)MYCBP (203361_s_at)−−− (234986_at)GALC (204417_at)ZNF512B (55872_at)−−− (226641_at)LOC388789 (226236_at)EHD1 (209037_s_at)ASPHD1 (1553997_a_at)−−− (239484_at)−−− (242358_at)LIG4 (206235_at)CCDC92 (218175_at)−−− (228925_at)GARNL1 (214855_s_at)CYB5D1 (226833_at)KIF16B (219570_at)NALCN (242880_at)−−− (240064_at)ARPM1 (223665_at)−−− (236393_at)MTM1 (204101_at)FBXW2 (235195_at)FAF2 (212108_at)SGK3 (227627_at)SSX2IP (203019_x_at)RIPK2 (209545_s_at)LAMC2 (202267_at)TMEM107 (224496_s_at)TAS2R14 (235762_at)NCF2 (209949_at)SEC23B (201583_s_at)NUDT9 (218375_at)COPA (214337_at)ST7 (207871_s_at)UBAP2L (214695_at)NQO1 (201467_s_at)TIMM8B (223478_at)DHCR24 (200862_at)LONP2 (229663_at)ATP8B4 (220416_at)−−− (234987_at)ART3 (210147_at)C8orf42 (230903_s_at)EBF1 (227646_at)DAB2 (240873_x_at)SETD4 (219482_at)CPSF3L (232437_at)PGBD3 (232287_at)HSD17B12 (1554122_a_at)C12orf26 (229018_at)TUBE1 (230891_at)RPS6KA6 (220738_s_at)TBRG1 (230320_at)CHST11 (226368_at)CABYR (224279_s_at)HDAC11 (227679_at)CLCN5 (206704_at)AHNAK2 (1558378_a_at)ZNF207 (228157_at)COG1 (227784_s_at)SLC7A6 (203578_s_at)−−− (243704_at)LOC100131813 (230939_at)CDH6 (210602_s_at)KLHDC10 (209254_at)HBEGF (38037_at)SPON1 (213993_at)−−− (229111_at)DDX52 (212834_at)−−− (235660_at)SRPR (200918_s_at)TMCC1 (213351_s_at)PPAPDC1B (226384_at)GOPC (236862_at)C20orf30 (220477_s_at)PPAPDC1B (223569_at)−−− (228013_at)GIPC1 (207525_s_at)TMEM87B (225412_at)CRKRS (225690_at)GLIPR1 (226136_at)UCRC (228142_at)ITPR1 (203710_at)UTP14C (203614_at)FAM41C /// RPL23AP7 /// RPL23AP82 (232899_at)TMEM63A (228549_at)CFH (213800_at)TNFSF12 (205611_at)TMBIM4 (219206_x_at)C1orf71 (1554661_s_at)C12orf51 (211034_s_at)LOC729839 (236692_at)EGF (206254_at)LOC100130360 (244570_at)ZNF610 (235953_at)PPP1R1C (228646_at)−−− (243489_at)LOC692247 (1569453_a_at)−−− (228775_at)ATP2B4 (212136_at)MYOZ2 (207148_x_at)ALAS1 (205633_s_at)EEA1 (204840_s_at)PON2 (201876_at)HIST1H2BD (209911_x_at)SSR3 (237817_at)LRRN3 (209841_s_at)TMEM50A (217766_s_at)UACA (238868_at)KDELR3 (207264_at)PAPSS2 (203058_s_at)SCN9A (229199_at)−−− (226779_at)BCAP29 (225677_at)SDF4 (232032_x_at)MED31 (219318_x_at)−−− (226805_at)ASAH1 (213902_at)−−− (212528_at)PRSS35 (235874_at)DSEL (232825_s_at)PPAPDC1B (226150_at)GALNT1 (201724_s_at)OCRL (208316_s_at)SMPD1 (216230_x_at)ATG4A (213115_at)TACC1 (217437_s_at)MBOAT7 (209179_s_at)TMEM110 (227078_at)KTELC1 (222681_at)ALDH3B1 (205640_at)IDS (210666_at)SEMA4F (210124_x_at)VCPIP1 (1556228_a_at)RSPH3 (223713_at)FAM66C /// FAM66D (1559952_x_at)−−− (235150_at)AFP (204694_at)LOC150759 (213703_at)PRSS23 (229441_at)KIF1B (209234_at)ARSD (223696_at)−−− (1560661_x_at)MTERFD3 (225341_at)RNF128 (219263_at)FBXL20 (239224_at)LPIN1 (212272_at)RETSAT (1566472_s_at)HEY1 (44783_s_at)GLRB (244680_at)IDE (203327_at)−−− (1563376_at)−−− (232413_at)NRD1 (229422_at)CCDC14 (1561054_a_at)−−− (238479_at)LEPR (211355_x_at)SERPINE1 (1568765_at)DDIT3 /// NR1H3 (209383_at)AQP3 (39248_at)VPS53 (229653_at)SLC26A11 (226679_at)IL1RAPL1 (220663_at)ANKRD29 (238332_at)−−− (232429_at)−−− (230088_at)−−− (229308_at)GNPTAB (240106_at)SLC39A8 (209267_s_at)GALM (234974_at)IFNAR1 (225669_at)−−− (244502_at)SLC38A10 (230448_at)ATF7 (235160_at)−−− (1556942_at)LOC100131904 (240329_at)ATP1B3 (226570_at)SLC25A37 (226179_at)−−− (225066_at)DIAPH2 (205726_at)VEPH1 (232122_s_at)C17orf63 (229418_at)TMEM107 (238590_x_at)HECW2 (232080_at)−−− (242705_x_at)ARHGAP18 (225173_at)NMNAT2 (1552712_a_at)CPT1A (203633_at)−−− (234219_at)SNRPN (226587_at)EIF4EBP2 (224653_at)−−− (241658_at)−−− (241015_at)−−− (241302_at)SLC16A6 (207038_at)KCNMA1 (221583_s_at)SLC38A7 (56821_at)FBXL18 (215068_s_at)−−− (214803_at)CTSC (225646_at)GAS2L1 (31874_at)PIGF (205078_at)LARP6 (236565_s_at)PLA2G12A (221027_s_at)AGBL5 (238889_at)SSX2IP (203018_s_at)SLC35F5 (220123_at)SH3KBP1 (235692_at)MED31 (222867_s_at)HMGCR (202540_s_at)CD44 (234418_x_at)SSX2IP (210871_x_at)VCPIP1 (219810_at)ZNF124 (234394_at)NAP1L3 (204749_at)SSX2IP (203015_s_at)GPNMB (201141_at)GPD1L (212510_at)PIK3R3 (202743_at)BC036928 (231260_at)CHCHD10 (224932_at)TCTN3 (212121_at)DGKA (211272_s_at)ZNF18 (226787_at)MYPN (235367_at)SELT (217811_at)EIF5A2 (235289_at)CCDC80 (225241_at)NUDT6 (220183_s_at)HOPX (211597_s_at)DDAH1 (1553565_s_at)DIO2 (203699_s_at)FAM55C (217540_at)STYK1 (220030_at)KRTAP2−4 (1555673_at)SLC30A1 (228181_at)CDH6 (205532_s_at)HERC4 (208055_s_at)CPD (229600_s_at)NQO1 (201468_s_at)SMAD9 (227719_at)PDCD6 (203415_at)SRRM1 (201224_s_at)LOC645895 /// MYBL1 (231268_at)ILF3 (217804_s_at)−−− (239816_at)ACP1 (201629_s_at)RUVBL1 (201614_s_at)FGFR1OP (205587_at)NOVA1 (207437_at)C14orf102 (235212_at)NOD1 (224190_x_at)MALL (209373_at)EZR (208621_s_at)−−− (244331_at)C19orf72 (221851_at)−−− (227044_at)PHF19 (227212_s_at)SRRT (201680_x_at)VANGL1 (219330_at)ADAMTSL1 (239909_at)−−− (1559331_x_at)PA2G4 (208676_s_at)ZNF502 (232247_at)THYN1 (223711_s_at)PCNT (203660_s_at)KALRN (206078_at)ELAVL1 (201727_s_at)CCT2 (201946_s_at)DDX11 (232816_s_at)SGEF (227197_at)ZNF788 (244552_at)WDR5 (223308_s_at)SRGAP1 (227484_at)DHPS (211558_s_at)−−− (1556321_a_at)TBC1D8 (241017_at)LYAR (223413_s_at)TH1L (225261_x_at)SNRPD1 (202691_at)KIAA1731 (1569302_at)RAD51C (209849_s_at)NUP37 (218622_at)DARS2 (218365_s_at)WDR67 (214061_at)AIM1 (212543_at)ERLIN1 (202444_s_at)EZR (217234_s_at)VANGL1 (229997_at)FAM164A (1560197_at)SIVA1 (210792_x_at)CCDC90A (220094_s_at)PBRM1 (224152_s_at)ARNTL2 (220658_s_at)−−− (239054_at)FOSL1 (204420_at)C10orf116 (203571_s_at)GPATCH4 (221733_s_at)CBR3 (205379_at)DUS4L (205762_s_at)RIOK1 (224450_s_at)ZNF530 (232228_at)−−− (1555995_a_at)UBE3C (1555405_at)CBFB (206788_s_at)RASGRP1 (205590_at)RGS4 (204339_s_at)ZNF85 (206572_x_at)KIAA1644 (52837_at)KIAA0586 (37232_at)ORC2L (204853_at)RGS4 (204337_at)CNTLN (239989_at)IQGAP3 (241939_at)PREP (229644_at)PFTK2 (239201_at)CCDC82 (1554785_at)STOML2 (215416_s_at)MED28 (218438_s_at)GTSE1 (204315_s_at)SEPT10 (214720_x_at)LASS6 (212442_s_at)PRKCA (215194_at)MCM5 (216237_s_at)EXOSC3 (223490_s_at)CCDC150 (232398_at)C9orf102 (228211_at)LYAR (223414_s_at)HADH (201035_s_at)MNS1 (219703_at)ZW10 (204812_at)CCDC59 (222792_s_at)TOP3A (214299_at)PNPT1 (225291_at)RREB1 (215032_at)BRCA1 (211851_x_at)C3orf37 (201678_s_at)FOXRED2 (220707_s_at)UBE2G1 (226005_at)C21orf58 (1553789_a_at)GRPR (207929_at)ADAMTSL1 (237217_at)KCNQ5 (244623_at)ZNF354C (234409_at)LOC100192378 (1559965_at)PDE3B (208591_s_at)−−− (237688_at)KRT7 (214031_s_at)−−− (241875_at)METTL1 (204027_s_at)GPHN (220773_s_at)−−− (237936_at)ARL9 (229062_at)−−− (228812_at)PDE6D (231065_at)−−− (239756_at)ACER3 (222688_at)−−− (1568589_at)ZNF662 (228538_at)KCNQ5 (223891_at)RBM15 (1555760_a_at)ANXA2 (1568126_at)CHRDL1 (209763_at)GINS3 (218719_s_at)UTRN (213022_s_at)UTRN (213023_at)USP6NL (238164_at)CCDC101 (48117_at)TUBD1 (210389_x_at)ASXL1 (212234_at)CLSPN (1553120_at)BUB3 (201456_s_at)DPH5 (224060_s_at)AR (211110_s_at)ARNTL2 (224204_x_at)KHSRP (212303_x_at)−−− (240217_s_at)CASP2 (209812_x_at)RGS4 (204338_s_at)CHRNA5 (206533_at)C12orf45 (226349_at)EMG1 (209233_at)DNAJA4 (1554334_a_at)ABCC9 (208561_at)EML5 (1570393_at)PPP2R5C (1554365_a_at)RMND1 (220329_s_at)MARCH1 (219574_at)SLC7A14 (1556641_at)−−− (1568742_at)−−− (214078_at)FAM110B (221959_at)SNRPF (203832_at)C12orf65 (223476_s_at)EID2B (242470_at)NLGN1 (231361_at)ZNF254 (206862_at)KIAA2013 (1555933_at)POLR3G (206653_at)TMEM97 (212279_at)−−− (243701_at)TIMP4 (206243_at)RHOBTB3 (216049_at)N4BP2 (228242_at)ODF2 (225617_at)CREB1 (204314_s_at)DMC1 (208382_s_at)GTSE1 (229343_at)−−− (241838_at)IRX2 (228462_at)ZMYM1 (220206_at)ZNF585A (227674_at)−−− (1562163_at)−−− (243499_at)KCNS1 (207366_at)−−− (236304_at)−−− (238156_at)KCNG1 (214595_at)SFRS1 (201741_x_at)FUBP1 (212847_at)C18orf10 (213616_at)TRIM21 (204804_at)SPATA5L1 (218933_at)NFIB (213032_at)LMCD1 (227317_at)ELF4 (203490_at)SNRNP200 (200058_s_at)BEND3 (227920_at)MTIF2 (203095_at)ZNF138 (244743_x_at)NARG1 (222837_s_at)NXT1 (218708_at)CDC23 (202892_at)RPIA (212973_at)CXCL12 (203666_at)GEMIN5 (225712_at)TSR1 (221987_s_at)SYNPO2L (243313_at)−−− (243555_at)LOC729810 (229200_at)−−− (234104_at)−−− (236606_at)SENP1 (1552812_a_at)RICS (203431_s_at)ZNF268 (209989_at)APOLD1 (221031_s_at)HNRNPA0 (229083_at)NIF3L1 (218133_s_at)TACC2 (202289_s_at)GTF3A (215091_s_at)TTF2 (204407_at)C13orf23 (225887_at)RPS24 (1555878_at)PATL1 (225466_at)−−− (237347_at)CCHCR1 (37425_g_at)ZDHHC13 (219296_at)HNRNPA3 (211930_at)SMC1A (217555_at)ARMC8 (1555281_x_at)DFNA5 (203695_s_at)GPBP1 (224648_at)WDR54 (225898_at)IPO11 (234304_s_at)−−− (244826_at)FKBP11 (228308_at)MLPH (218211_s_at)TRAF5 (204352_at)CSRP2BP (228543_at)C22orf29 (219560_at)−−− (222306_at)−−− (241435_at)−−− (220820_at)NEDD4L (212448_at)LOC643201 (235416_at)MAP2K6 (205698_s_at)DCLRE1A (209804_at)BTG3 (215425_at)PAQR4 (212858_at)−−− (240505_at)HAUS2 (229181_s_at)TTLL12 (216251_s_at)ZNF826 (1560853_x_at)BAZ1B (211313_s_at)C16orf59 (219556_at)−−− (241737_x_at)CCHCR1 (42361_g_at)FAR1 (224865_at)SRGAP1 (1554473_at)TXNDC16 (226747_at)−−− (236476_at)MCRS1 (202556_s_at)AGTR1 (205357_s_at)TADA3L (215273_s_at)ZNF438 (229743_at)CEP72 (219531_at)PKN3 (226299_at)C9orf140 (225777_at)FLJ20674 (223845_at)DEF6 (226659_at)−−− (1569545_at)LOC220729 /// SDHA /// SDHALP1 /// SDHALP2 (230077_at)CABLES2 (226004_at)CARD8 (228641_at)ESPL1 (38158_at)CP110 (1569353_at)WDR4 (241937_s_at)CNOT7 (1552344_s_at)SDCCAG8 (1554237_at)−−− (1560871_a_at)GIT2 (204982_at)LOC100128191 (227578_at)MGC16121 (228235_at)FBF1 (1555288_s_at)C11orf49 (203257_s_at)ZBTB10 (233899_x_at)−−− (1560297_at)MRE11A (211334_at)SR140 (236696_at)ZNF283 (243188_at)−−− (238910_at)MTPAP (218947_s_at)−−− (216740_at)POLH (1557700_at)CEP152 (215170_s_at)−−− (243879_at)FUT8 (203988_s_at)NFIA (226806_s_at)−−− (239303_at)FOXRED2 (231846_at)C20orf117 (225473_at)SRRT (214127_s_at)−−− (1568813_at)−−− (221038_at)C7orf44 (209445_x_at)ZNF326 (241720_at)−−− (226556_at)LOC643201 (1570445_a_at)FLJ36840 (231527_at)PLCL2 (213309_at)SCUBE2 (219197_s_at)GIGYF2 (1558305_at)GAPVD1 (235553_at)SLC25A13 (229061_s_at)ZNF496 (225349_at)−−− (231127_at)PLCE1 (205111_s_at)tcag7.929 (1562664_at)C4orf30 (219717_at)NSMAF (1558775_s_at)RTN4IP1 (224509_s_at)LIFR (227771_at)GRLF1 (202046_s_at)−−− (236985_at)CNRIP1 (226751_at)NARG1 (219158_s_at)GPHN (223319_at)C1orf135 (222946_s_at)−−− (235385_at)−−− (233053_at)RABL5 (222742_s_at)SNRPA1 (216977_x_at)NSMAF (232149_s_at)−−− (239815_at)C13orf23 (218420_s_at)C1orf43 (1555225_at)UNQ565 (236059_at)ING5 (228287_at)RYR3 (206306_at)NSMCE2 (226536_at)SUSD4 (219389_at)DHX8 (203334_at)RAP2B (238622_at)LOC100131612 /// MED27 (51176_at)FDX1 (203647_s_at)B4GALT6 (235333_at)SRRT (222047_s_at)MRPL9 (211594_s_at)TAF1B (214690_at)MED30 (230555_s_at)NOVA1 (205794_s_at)TSGA14 (215637_at)−−− (237422_at)NUP205 (222382_x_at)PTPRE (221840_at)C5orf54 (220770_s_at)WWC3 (225273_at)DOHH (208141_s_at)DIAPH1 (215541_s_at)WRAP53 (44563_at)−−− (241702_at)FERMT1 (60474_at)DEPDC4 (1561114_a_at)IRS1 (238933_at)MRPS14 (203800_s_at)ZNF212 (203985_at)RBM8A (1554602_at)SP3 (232529_at)CFDP1 (236588_at)LZIC (226087_at)−−− (225193_at)ARHGDIB (201288_at)C20orf7 (222894_x_at)−−− (1565928_at)DFFA (223518_at)C5orf35 (238465_at)RPUSD4 (225398_at)FAM176A (227828_s_at)ARNTL2 (223586_at)−−− (1562110_at)PHLPPL (213407_at)−−− (236987_at)NRP1 (210615_at)ZSCAN12L1 (239157_at)BTBD11 (228570_at)TTC30A (213679_at)−−− (1568799_at)DENND1A (219763_at)MMACHC (211774_s_at)−−− (237365_at)KIAA0586 (205631_at)−−− (243806_at)ADAMTSL1 (229585_at)SR140 (212061_at)CUL3 (201370_s_at)ZNF185 (203585_at)−−− (238785_at)IQCH (239813_at)CCDC99 (221685_s_at)KIAA0020 (203712_at)TIMM10 (1555764_s_at)RNASEH2B (233156_at)−−− (243071_at)DLX1 (242138_at)LOC91431 (1565935_at)STEAP1 (205542_at)HIST1H2AL (214554_at)−−− (230483_at)LOC440288 (239792_at)LRRC59 (234812_at)NSMAF (203269_at)FABP4 (203980_at)GABRA5 (206456_at)CCDC138 (230339_at)KIF2A (203086_at)LCMT2 (204012_s_at)CNTLN (241696_at)HEATR6 (218991_at)B4GALT5 (221485_at)ZCCHC3 (225091_at)PARVB (37966_at)IMMP2L (227153_at)MTCP1NB (216862_s_at)CACHD1 (225627_s_at)ATPIF1 (223339_at)ZNF829 (237306_at)CCDC152 (242519_at)CAD (202715_at)RPL26L1 (218830_at)PPRC1 (203737_s_at)R3HDM1 (202754_at)CHML (206079_at)GTF3C3 (218343_s_at)VMA21 (235237_at)PRICKLE4 /// TOMM6 (223516_s_at)ZNF606 (229707_at)GARNL1 (234923_at)FLI1 (210786_s_at)ZC3H12C (231899_at)C6orf26 /// MSH5 (210410_s_at)FRMD4A (1560031_at)MIB1 (224722_at)SNHG12 (223774_at)−−− (242966_x_at)DIRAS3 (215506_s_at)CENPI (1563223_a_at)RBM15 (232971_at)−−− (241941_at)−−− (1560209_at)SLC19A1 (211576_s_at)ZNF586 (219711_at)PCOLCE2 (219295_s_at)SAP130 (220367_s_at)EML5 (1568777_at)−−− (231515_at)−−− (240636_at)ZNF207 (229765_at)SNRPA1 (242146_at)HSPA14 (227650_at)RBM27 (243295_at)RERE (200939_s_at)−−− (229926_at)MGA (235409_at)PEX14 (1558915_a_at)EIF1AD (223682_s_at)DDX19B (230974_at)−−− (244188_at)−−− (240113_at)C7orf40 (225699_at)LOC645733 (241234_at)DCLRE1C (242927_at)SERPINB9 (209722_s_at)−−− (215861_at)FOXP1 (1558996_at)ZBED1 (203043_at)TMEM68 (227936_at)FLJ36031 (229521_at)B3GALTL (227083_at)TFAP2A (204653_at)KCTD6 (238077_at)NUP133 (233421_s_at)FAM116A (226965_at)TDRD3 (214028_x_at)TOX (204529_s_at)−−− (230850_at)ZNF502 (229532_at)GNAI3 (201181_at)DNMT3B (220668_s_at)VTI1A (242356_at)GTF3C4 (243228_at)ATF7IP2 (219870_at)TAF1A (206613_s_at)FERMT1 (218796_at)DYRK2 (202969_at)hCG_1645220 (241710_at)MBD5 (220195_at)POLS (202466_at)GPR39 (229105_at)HNRNPA2B1 (225107_at)PBX2 (202875_s_at)SNHG3 (215011_at)SETD2 (212493_s_at)RNF207 (1555870_at)BAT1 (200041_s_at)TSHZ1 (223283_s_at)MAP3K4 (204089_x_at)BBS9 (1555555_at)SF3A1 (201357_s_at)CNOT10 (223219_s_at)HEATR6 (65493_at)TMEM144 (219750_at)SEMA3D (215324_at)−−− (237239_at)MAGOHB (222776_at)C21orf63 (227188_at)NUP50 (218295_s_at)LOC145783 (229013_at)NBN (202905_x_at)−−− (241410_at)DHX9 (212107_s_at)RAD51L3 (209965_s_at)UTP15 (228050_at)CHKA (204233_s_at)CWF19L2 (228916_at)POT1 (204353_s_at)GMEB1 (235232_at)NEK3 (213116_at)FANCM (242711_x_at)GMPPB (219920_s_at)FTSJ2 (222130_s_at)GEMIN4 (205527_s_at)EIF2AK4 (237145_at)−−− (242389_at)SLC25A13 (203775_at)LPPR4 (213496_at)−−− (239842_x_at)FAM26F (228362_s_at)BXDC2 (219177_at)RQCD1 (1554080_at)MAP3K4 (216199_s_at)ARID1A (212152_x_at)TRMT5 (227653_at)PCGF6 (224326_s_at)FARS2 (204282_s_at)DZIP3 (207232_s_at)L2HGDH (224460_s_at)MTERFD1 (219363_s_at)CRTC3 (218648_at)−−− (235502_at)−−− (229498_at)PIAS2 (214442_s_at)METT5D1 (1565900_at)SEPSECS (1553167_a_at)−−− (1566202_at)TTC26 (219758_at)PCDH7 (210273_at)−−− (1569439_at)BHLHB9 (1559510_at)−−− (228366_at)C15orf41 (232506_s_at)ZCCHC5 (1552935_at)FLVCR1 (222906_at)−−− (1558783_at)CD3EAP (205264_at)−−− (1565830_at)MESDC1 (223264_at)CKAP2 (1554264_at)PAXIP1 (212825_at)−−− (235738_at)PHKA2 (209438_at)LOC100132815 (227234_at)PTER (222798_at)MPHOSPH9 (1558369_at)SUV420H1 (222759_at)BRD7 (222737_s_at)FAM26F (229391_s_at)ZNF292 (1562991_at)−−− (239065_at)GRIK2 (213845_at)PARP2 (214086_s_at)ZNF718 (1553269_at)PBRM1 (223399_x_at)ZNF850P (244640_at)LOC729088 (238833_at)GABRA4 (233437_at)ANKRD18A (242045_at)LOC100128361 (242207_at)KLF12 (206966_s_at)SNX19 (1561710_at)ARIH2 (1559121_s_at)OBFC2B (218903_s_at)FLJ10038 (236164_at)ME2 (210153_s_at)ZNF92 (235170_at)−−− (244000_at)−−− (237962_x_at)RPS28 (208903_at)TMED8 (225343_at)REL (206035_at)ENDOD1 (212570_at)IQCB1 (211707_s_at)INPP4B (205376_at)MTCP1NB (210212_x_at)ATP11B (1554556_a_at)TRIM24 (213301_x_at)NFYB (244704_at)DENND4B (202860_at)ANAPC1 (218575_at)MPP6 (205429_s_at)VPRBP (226477_at)ASH2L (209517_s_at)CREB1 (237289_at)GPR161 (214104_at)−−− (228659_at)−−− (1563469_at)GATAD2A (236932_s_at)DDX54 (225428_s_at)ACER3 (231321_s_at)GDAP1 (221279_at)−−− (228643_at)BAT2D1 (211944_at)GMEB1 (235233_s_at)−−− (220701_at)LOC285463 (1563571_at)YWHAH (242325_at)XPO5 (223055_s_at)RIF1 (233781_s_at)SAE1 (1555618_s_at)CHAF1A (203975_s_at)CREB3L2 (228759_at)SFN (33322_i_at)GNB4 (223488_s_at)CDC25A (1555772_a_at)WDHD1 (204727_at)TOP1MT (225802_at)RBP1 (239782_at)SMAD3 (205396_at)−−− (240219_at)MAGEL2 (219894_at)−−− (220906_at)ZBTB44 (1554470_s_at)WTAP (210285_x_at)TAF1B (216941_s_at)RAD51 (205023_at)SMC5 (212926_at)TNPO3 (212318_at)ATP11C (242690_at)MEX3D (91816_f_at)SPATA6 (238459_x_at)SP1 (224760_at)RNF220 (219988_s_at)CDV3 (213554_s_at)RCC1 /// SNHG3−RCC1 (215747_s_at)MEX3A (236885_at)RBM12B (51226_at)NCAPH2 (205086_s_at)−−− (243286_at)MTA2 (203444_s_at)RHOBTB3 (216048_s_at)DPF3 (235357_at)STAG3 (219753_at)TFDP1 (204147_s_at)KCTD14 (219545_at)TEAD2 (238321_at)ASXL1 (244519_at)PIF1 (1555591_at)LIN7A (240027_at)MARVELD2 (235955_at)−−− (217300_at)COQ7 (210820_x_at)WBP4 (203597_s_at)CLN6 (222539_at)LOC283624 (240902_at)ZMYND8 (209048_s_at)FOXRED2 (233250_x_at)KIAA0922 (235674_at)BATF3 (220358_at)LCTL (1563899_at)CCHCR1 (209698_at)ANKRD13C (1556361_s_at)MTHFS (203433_at)C20orf94 (236390_at)BCL2L11 (222343_at)NOLC1 (211949_s_at)DLEU2 (1569600_at)MYO19 (219320_at)EEF1D (203113_s_at)PSMC3 (201267_s_at)KCNRG (240288_at)ABCF1 (200045_at)DNAJC8 (205545_x_at)PARN (203905_at)GPATCH4 (224634_at)C19orf2 (214173_x_at)MAP2K6 (205699_at)PACSIN2 (1554691_a_at)−−− (227615_at)B4GALT5 (221484_at)COPG2 (223457_at)TTC26 (233999_s_at)−−− (241205_at)−−− (240712_s_at)C11orf51 (204218_at)ALDH1B1 (209645_s_at)TLE3 (228340_at)ANKRD50 (236189_at)PLCE1 (205112_at)FRYL (1563687_a_at)DCPS (218774_at)MLLT10 (216503_s_at)CEP250 (209495_at)C1orf163 (219420_s_at)TH1L (220607_x_at)SAFB (201748_s_at)TH1L (225006_x_at)NUBP1 (203978_at)MIOS (206860_s_at)TELO2 (34260_at)RNF26 (224947_at)UTP20 (209725_at)SMAD3 (205397_x_at)PRKCA (206923_at)RPL5 (1556498_at)PABPN1 (201544_x_at)CXorf15 (1557954_at)−−− (234652_at)TCF3 (213809_x_at)NFKBIA (201502_s_at)TCF3 (213731_s_at)ASF1A (203428_s_at)FUBP1 (203091_at)BAZ1B (229658_at)MTMR1 (216095_x_at)SAFB (213635_s_at)CEP57 (203492_x_at)DKC1 (201478_s_at)C3orf52 (219474_at)TH1L (225865_x_at)CSRP2BP (228544_s_at)SIN3A (238006_at)RAB8A (208819_at)AK2 (212175_s_at)LOC150776 /// SMPD4 (207856_s_at)LAMA2 (213519_s_at)SF3A3 (203818_s_at)CEP78 (228774_at)FST (207345_at)HAT1 (203138_at)NUP93 (202188_at)IPPK (222823_at)C5orf37 (227267_at)MIOS (211724_x_at)MRPL1 (223154_at)RPAIN (216962_at)MRPL40 (203152_at)CCDC12 (226011_at)WDR75 (224721_at)SNX5 (229981_at)ALKBH3 (226127_at)STAG2 (207983_s_at)−−− (235596_at)GLE1 (206920_s_at)ARNTL2 (1563101_at)LOC728715 /// OVOS /// OVOS2 (228245_s_at)−−− (241100_at)−−− (234153_at)−−− (235813_at)FRYL (1554260_a_at)MAP4K4 (1558732_at)XPO4 (222649_at)PDS5A (213983_s_at)−−− (241950_at)LOC100192378 (1559966_a_at)GPATCH4 (224632_at)NAP1L4 (1556567_at)−−− (240181_at)OSGEPL1 (220631_at)PATZ1 (211391_s_at)RAB31 (217763_s_at)RBMS3 (206767_at)−−− (240281_at)ID4 (209292_at)FAM122B (225362_at)C14orf93 (219009_at)TTF2 (1555307_at)HRAS (212983_at)SLC8A1 (211805_s_at)CENPN (234811_at)NGF (206814_at)YY2 (216531_at)MTMR1 (214975_s_at)ZNF473 (213124_at)LOC731049 /// UBE2S (202779_s_at)PPP1CA (200846_s_at)−−− (238372_s_at)USP31 (226035_at)NIP30 (222460_s_at)PPIF (201490_s_at)EML5 (242443_at)BTBD11 (238692_at)MOSC1 (218865_at)SLC8A1 (210804_x_at)SEMA7A (230345_at)SLC7A2 (207626_s_at)LIG3 (207348_s_at)RAD51C (206066_s_at)NIPSNAP1 (201708_s_at)−−− (237374_at)NONO (208698_s_at)NONO (210470_x_at)TBL1XR1 (222634_s_at)RYK (216976_s_at)MAD2L2 (223234_at)KITLG (211124_s_at)STAT5B (212550_at)−−− (237978_at)ZBTB38 (230754_at)GTPBP6 (203314_at)FKBP4 (200894_s_at)RNF219 (237686_at)SMARCA4 (212520_s_at)LOC387885 (226539_s_at)RSRC1 (219507_at)ZNF496 (1557616_at)SART1 (200051_at)−−− (230918_at)LOC100133233 /// TRAF3IP3 (213888_s_at)POLR3G (231544_s_at)−−− (236066_at)SFRS8 (202773_s_at)PRMT2 (228725_x_at)APEX1 (210027_s_at)EWSR1 (210011_s_at)−−− (233257_at)PIF1 (228252_at)RNASEH1 (218497_s_at)−−− (229821_at)TMEM39B (218770_s_at)−−− (236589_at)STARD8 (206868_at)−−− (242320_at)PTPRD (214043_at)NINL (207705_s_at)−−− (228717_at)−−− (243509_at)−−− (238704_at)−−− (242057_at)ORC5L (211212_s_at)NPM3 (205129_at)−−− (239321_at)LOC441528 (1564232_at)NLE1 (203866_at)−−− (242671_at)C15orf38 (228666_at)ING1 (208415_x_at)HP1BP3 (1554251_at)BTG3 (205548_s_at)FANCB (243597_at)DCTPP1 (218069_at)RPL10A (200036_s_at)TMEM65 (241342_at)FAM119A (1553743_at)ACSS3 (229222_at)KIAA1009 (206006_s_at)GANC (235714_at)SETBP1 (227478_at)ABHD3 (213017_at)PRKCE (236459_at)ANKRD50 (225735_at)−−− (213686_at)LOC401321 (232256_s_at)PURB (226762_at)SHISA3 (229485_x_at)NSL1 (230592_at)C3orf67 (239697_x_at)ELP4 (203829_at)PM20D2 (225421_at)KCNK1 (204679_at)−−− (235939_at)C10orf84 (218390_s_at)CARD6 (224414_s_at)PBRM1 (223400_s_at)HEATR3 (1554478_a_at)ZNF254 (236133_x_at)ZSCAN5A (219904_at)HMGA2 (1568286_at)PRDM5 (220792_at)FAM36A (224820_at)−−− (226821_at)CLCC1 (213628_at)HELLS (234040_at)−−− (242137_at)PXMP4 (219428_s_at)−−− (1564690_at)ANGEL2 (221826_at)AKAP5 (230846_at)IRAK3 (213817_at)CREB5 (229228_at)−−− (213598_at)NDRG4 (209159_s_at)SNW1 (222183_x_at)DLEU2 (1556821_x_at)MATR3 (228012_at)CDKL1 (207766_at)HDGFRP3 (216693_x_at)−−− (243405_at)TCF4 (212385_at)SIX4 (229796_at)ACSS3 (219616_at)MORN2 (226790_at)BEND6 (231175_at)CASP8AP2 (222201_s_at)−−− (236619_at)MRPS16 (222499_at)ANGEL2 (221825_at)MKS1 (218630_at)−−− (238617_at)HPS3 (227139_s_at)ZNF568 (1564356_at)−−− (1568611_at)−−− (228734_at)HSDL2 (215436_at)C20orf196 (243508_at)MRPS11 (215919_s_at)−−− (1560346_at)LCORL (235970_at)AMMECR1 (226421_at)OGG1 (205301_s_at)ZNF642 (1569107_s_at)BNC2 (229942_at)LRCH1 (235012_at)CCDC34 (1553666_at)NLGN1 (205893_at)DPY19L2P2 (215143_at)FOXRED1 (223128_at)FOXP1 (223936_s_at)USP28 (230623_x_at)TEK (217711_at)ZNF492 (215532_x_at)STRBP (229513_at)−−− (242126_at)−−− (244032_at)CPM (206100_at)PTER (218967_s_at)PHF14 (204525_at)KREMEN1 (235370_at)−−− (242834_at)ORC4L (203352_at)ACER3 (227776_at)−−− (1556352_at)ZMYM6 (227595_at)−−− (235419_at)LOC286052 (241370_at)−−− (242786_at)−−− (1555974_a_at)ACTR5 (222147_s_at)INTS6 (1568695_s_at)−−− (1559384_at)PPM2C (218273_s_at)TMEM92 (231408_at)−−− (230786_at)SPATA5 (242251_at)FAM13A (202972_s_at)ZNF644 (1553725_s_at)−−− (226316_at)GRTP1 (229377_at)ZNF644 (222580_at)−−− (235693_at)TCF7L2 (212761_at)SMARCAD1 (223197_s_at)ARNTL (209824_s_at)C17orf100 (229071_at)−−− (239486_at)HMGA2 (1568287_at)FAM85A (227917_at)TRIM61 (238990_x_at)HTR2B (206638_at)KCNT2 (244455_at)−−− (226341_at)NEK4 (204634_at)SLFN13 (1553423_a_at)SEPT6 (213666_at)TBX3 (219682_s_at)SMO (218629_at)−−− (230710_at)ARID2 (231090_s_at)CEP97 (235918_x_at)ZNF462 (244007_at)VASH2 (235343_at)−−− (235612_at)ISOC1 (218170_at)STMN1 (217714_x_at)LOC541472 (243977_at)PTPN2 (204935_at)VANGL2 (226029_at)TCOF1 (202385_s_at)BEND5 (219670_at)CDO1 (204154_at)RFC3 (231119_at)N4BP2L2 (202258_s_at)PMS1 (213677_s_at)C18orf54 (244324_at)SNX26 (213827_at)HADH (201036_s_at)RP6−213H19.1 (218499_at)PRKCA (213093_at)ARID2 (225486_at)−−− (238735_at)ZBTB26 (227162_at)LOC389765 (230815_at)ZNF214 (243456_at)−−− (242769_at)C14orf102 (227575_s_at)HNRNPA0 (201055_s_at)MAGOH2 (217693_x_at)CRIPT (218643_s_at)ERH (200043_at)CHML (1565951_s_at)−−− (222335_at)ZBTB44 (225845_at)USP33 (214843_s_at)C1orf174 (222000_at)ZNF180 (219495_s_at)TADA1L (225455_at)LRRIQ3 (235498_at)ZBTB24 (205340_at)NSL1 (209483_s_at)ZNF765 (1558943_x_at)−−− (241824_at)CISD2 (226686_at)−−− (238443_at)NUP43 (219007_at)CETN3 (209662_at)H2AFV (212205_at)UBA6 (222602_at)−−− (229861_at)HES1 (203394_s_at)LCORL (232293_at)NUDT21 (224830_at)MCM4 (222036_s_at)PRIM2 (205628_at)MED4 (222438_at)PNPLA4 (209739_s_at)CCNE2 (205034_at)HAUS6 (218602_s_at)MYH10 (212372_at)CBX3 (200037_s_at)HNRNPA1 /// HNRNPA1L2 /// HNRPA1L−2 /// LOC100128836 /// LOC120364 /// LOC391670 /// LOC402112 /// LOC642817 /// LOC643033 /// LOC644037 /// LOC645001 /// LOC728170 /// LOC728643 /// LOC728732 /// LOC729102 /// LOC729366 /// LOC730246 /// RP11−569O4.6 (216559_x_at)C21orf91 (226109_at)KPNA2 (201088_at)FAM98B (1564637_a_at)ATF1 (1558233_s_at)−−− (1558102_at)LSM2 (209449_at)NFYB (218129_s_at)CA12 (204508_s_at)FAM128A (213166_x_at)SRGN (201859_at)−−− (217322_x_at)CD274 (223834_at)ERO1L (218498_s_at)ABCB10 (223320_s_at)MTR (203774_at)CRIPT (227942_s_at)MTSS1L (1556175_at)GPC2 (239422_at)GRPEL2 (226881_at)CAMTA1 (225692_at)ZBTB8A (235142_at)LSM5 (202903_at)ROD1 (214697_s_at)TRHDE (219937_at)SLC25A40 (227012_at)SMAD4 (1565703_at)ZNF92 (1564962_at)ZNF618 (226592_at)LYPLA1 (203007_x_at)−−− (229371_at)−−− (220450_at)METTL4 (232194_at)NSD1 (235760_at)−−− (233518_at)−−− (242766_at)−−− (236425_at)FAM76B (1553749_at)PRPS2 (230352_at)CHD1L (1556988_s_at)MBP (225407_at)−−− (242500_at)CEP57 (203493_s_at)HDGF (216484_x_at)−−− (229303_at)FANCA (236976_at)CBX2 (226473_at)TET1 (228906_at)DCTN1 (204296_at)NFIA (229994_at)METTL10 (226631_at)MED30 (227786_at)SLBP (206052_s_at)PSMC3IP (205956_x_at)MAPK13 (210059_s_at)ZNF511 (225307_at)BAZ1B (213336_at)FANCB (1557217_a_at)MCM5 (201755_at)ADARB1 (234799_at)CECR5 (218592_s_at)HNRNPC (214737_x_at)FOSL2 (225262_at)C4orf46 (235088_at)CKAP2 (218252_at)SPIN4 (228654_at)RIF1 (226503_at)KCTD14 (58916_at)CXorf26 (224177_s_at)TUBGCP4 (211337_s_at)CDH4 (220227_at)−−− (244338_at)ACOT4 (229534_at)C3orf75 (223277_at)−−− (1556911_at)−−− (242155_x_at)BIRC3 (210538_s_at)KTI12 (225642_at)CEP135 (207286_at)−−− (244778_x_at)−−− (238566_at)LGTN (218253_s_at)SRR (222844_s_at)FLI1 (204236_at)C6orf130 (238860_at)TSEN2 (219581_at)USP39 (217829_s_at)CCDC21 (227818_at)OAZ3 (213863_s_at)HNRNPU (225805_at)TAF9 (202168_at)ZNF430 (206829_x_at)ESPL1 (204817_at)QSER1 (219705_at)BLMH (202179_at)STAG1 (202293_at)−−− (232852_at)HIST1H4D (208076_at)LOC283392 (1560697_at)−−− (244551_at)ZNF57 (1554628_at)PIGX (227403_at)−−− (1566445_at)MAPK8 (229664_at)MRPS17 /// ZNF713 (218982_s_at)CPSF3 (225082_at)MYST3 (216361_s_at)DDX46 (202462_s_at)RNASEN (218269_at)−−− (235268_at)BMS1 (203082_at)GLI3 (227376_at)C1orf131 (226242_at)PRKRA (209139_s_at)PBX3 (204082_at)CP (228143_at)H3F3B (211998_at)CTNNBL1 (221021_s_at)AFAP1L1 (226955_at)TMEM169 (228981_at)SMARCA4 (213720_s_at)RBM23 (219816_s_at)PDE8A (212521_s_at)−−− (242965_at)PCK2 (202847_at)SESTD1 (227041_at)P4HA3 (228703_at)ACBD6 (225317_at)ETV6 (235056_at)COBRA1 (202757_at)PGK1 (217383_at)CEBPD (213003_s_at)SEMA5A (213169_at)ARNT2 (202986_at)PNMAL1 (218824_at)SCD (223839_s_at)VEZF1 (202172_at)AMOTL1 (225450_at)FAM162A (224345_x_at)MCM3APAS (220459_at)TCF7L1 (221016_s_at)COL14A1 (216865_at)COL18A1 (209082_s_at)USP3 (221654_s_at)PPIL3 (224364_s_at)TIMELESS (203046_s_at)SLC7A1 (212295_s_at)C18orf54 (229442_at)ENY2 (226775_at)C20orf72 (225890_at)PHF14 (228095_at)SLC36A4 (234978_at)ZNF292 (212366_at)XPO1 (208775_at)MYH10 (213067_at)SEMA4C (46665_at)PRIM1 (205053_at)SNX5 (217792_at)HNRNPA1 /// HNRNPA1L1 /// HNRNPA1L2 /// HNRPA1L−2 /// HNRPA1P5 /// LOC100128836 /// LOC391670 /// LOC402112 /// LOC642817 /// LOC643033 /// LOC644037 /// LOC645001 /// LOC728170 /// LOC728732 /// LOC729366 /// LOC730246 /// RP11−569O4.6 (213356_x_at)E2F1 (204947_at)SSRP1 (200957_s_at)HSPB11 (215691_x_at)NASP (201969_at)MRPL39 (218558_s_at)ENOSF1 (204143_s_at)C14orf145 (1557755_at)IQGAP3 (1569061_at)−−− (1557121_s_at)USP37 (226729_at)NSMCE4A (219067_s_at)CNOT6 (217970_s_at)ERI2 (213365_at)SRGN (201858_s_at)CDC25A (204695_at)RBM12 (212168_at)EIF4A3 (201303_at)MSH2 (209421_at)BNIP3 (201848_s_at)HNRNPH3 (210588_x_at)RBM7 (218379_at)−−− (229704_at)BMP2K (219546_at)TGFBR3 (204731_at)GAS1 (204457_s_at)FOXL1 (243409_at)CDKN1B (209112_at)TNFRSF19 (227812_at)LITAF (200704_at)GPATCH2 (236026_at)MRE11A (205395_s_at)SYTL2 (220613_s_at)RIF1 (214700_x_at)−−− (235759_at)PHF17 (225820_at)CEP70 (1554489_a_at)RBL1 (205296_at)MTHFD1L (231094_s_at)AXL (202686_s_at)FBLN1 /// LOC100133843 (201787_at)DUT (208956_x_at)FBLN1 (202994_s_at)PLEKHA2 (225136_at)H2AFY2 (218445_at)EPB41 (225051_at)FAM26F (229390_at)HAUS4 (218383_at)GPC6 (223730_at)LOC100132181 /// LOC389831 (225062_at)HNRNPA1 (200016_x_at)ARL13B (228201_at)TCF4 (212387_at)C11orf74 (228249_at)PGK1 (217356_s_at)OLFML3 (218162_at)LRIG1 (211596_s_at)GAS7 (202192_s_at)TCF3 (209152_s_at)HNRPDL (212454_x_at)GLIS3 (230258_at)INHBB (205258_at)CCDC8 (223495_at)ZNF626 (1552643_at)THAP11 (212910_at)TAF11 (1558136_s_at)−−− (226311_at)NUP160 (212709_at)EPB41 (214530_x_at)CCDC59 (218936_s_at)GALNT12 (218885_s_at)FRZB (203698_s_at)SLC35F3 (229065_at)PGM1 (201968_s_at)FAM107B (223059_s_at)TCEA1 (216241_s_at)TFPI2 (209278_s_at)SYTL2 (232914_s_at)ASNS (205047_s_at)ERRFI1 (224657_at)CEBPG (225527_at)LOC254128 (235132_at)ZBED4 (204799_at)FAM13A (202973_x_at)GLUL (217202_s_at)−−− (227107_at)MTMR2 (203211_s_at)MTAP (204956_at)ANP32B (201305_x_at)GLUL (215001_s_at)UCHL5 (219960_s_at)SYNCRIP (217833_at)CDH11 (236179_at)DHFR (202534_x_at)WDR5 (225170_at)SGCE (204688_at)RBM10 (217221_x_at)−−− (227458_at)−−− (229830_at)ZNF496 (225335_at)HAUS6 (233655_s_at)SFRS4 (201696_at)NIPBL (212469_at)−−− (226826_at)RHOBTB3 (202976_s_at)MDM1 (220397_at)FAM13A (217047_s_at)MED6 (207079_s_at)ATPBD4 (238662_at)GBAS (201816_s_at)FZD1 (204451_at)LAMA1 (227048_at)TBL1X (213401_s_at)−−− (235570_at)ARHGEF5 (204765_at)RAB8B (226633_at)COL12A1 (233109_at)EPB41L3 (206710_s_at)ARMC8 (219094_at)KLHL7 (220239_at)MRPS9 (226749_at)LRRC8E (239433_at)CREB1 (204313_s_at)SPA17 (205406_s_at)GPR161 (230369_at)EPB41L3 (211776_s_at)RAD1 (204460_s_at)FAM107B (223058_at)PTPN1 (217689_at)TRRAP (202642_s_at)ZSWIM7 (229119_s_at)ZNF507 (226327_at)THUMPD1 (206555_s_at)RBM15B (226987_at)LAMA2 (216840_s_at)ATP8B3 (1554704_at)H2BFM /// H2BFXP (230664_at)GEN1 (228286_at)SAV1 (218276_s_at)INTS7 (218783_at)DULLARD (200035_at)ROBO4 (226028_at)GLT8D4 (235371_at)LOC100131897 (235236_at)FLRT1 (210414_at)ALG10B (228941_at)ZNF618 (226590_at)ZNF214 (220497_at)NFIA (224975_at)TSPAN2 (227236_at)ARIH2 (227932_at)−−− (241637_at)−−− (206548_at)DENND5B (238917_s_at)PTGFRN (224937_at)SR140 (212058_at)CASP6 (209790_s_at)MTMR2 (214649_s_at)DGCR14 (239730_at)RASL11B (219142_at)TTF1 (204772_s_at)FUS (200959_at)SEPHS1 (208939_at)DCP2 (244777_at)CHAF1A (203976_s_at)KLF12 (214276_at)RAD21 (200607_s_at)C16orf53 (218300_at)ZNF280D (1568951_at)RNF34 (229855_at)PAK1 (226507_at)S100A2 (204268_at)EFNB2 (202668_at)TMEM194B (238014_at)DDX18 (208897_s_at)ZBTB38 (1558733_at)MRPS31 (212604_at)LOC150763 (235557_at)ZFP91 (224631_at)ADNP2 (203321_s_at)PARP2 (204752_x_at)−−− (235999_at)ZFHX4 (1559270_at)PPP2R3A (207749_s_at)GATA2 (209710_at)MRPL15 (218027_at)USP13 (227788_at)E2F1 (2028_s_at)LOC283392 (1560698_a_at)CCDC34 (226287_at)MID1 (203637_s_at)DLG3 (212727_at)PUS7 (218984_at)TYMS (1554696_s_at)DUT (208955_at)ZNF22 (218005_at)CCNA2 (203418_at)DIAPH3 (229097_at)IDH2 (210046_s_at)KHDRBS1 (200040_at)NASP (201970_s_at)CKS1B (201897_s_at)SGOL1 (1553690_at)NRK (227971_at)SCARA3 (219416_at)GTSE1 (215942_s_at)TROAP (204649_at)WHSC1 (222777_s_at)TUBB2C (213726_x_at)EGR1 (227404_s_at)SCARA3 (223842_s_at)VRK1 (203856_at)CENPF (207828_s_at)SPAG5 (203145_at)MAMLD1 (205088_at)AKT3 (212607_at)−−− (231034_s_at)CDK4 (202246_s_at)SSRP1 (200956_s_at)HNRPDL (201993_x_at)RQCD1 (213179_at)TACC3 (218308_at)CDCA8 (221520_s_at)MAZ (212064_x_at)FEN1 (204768_s_at)THG1L (219122_s_at)MAZ (228798_x_at)DNAJC9 (213088_s_at)−−− (242787_at)SYNJ2 (210612_s_at)C1orf156 (213528_at)RFC2 (203696_s_at)FANCA (203805_s_at)TNFAIP8L1 (227420_at)NT5DC4 (1560204_at)SMC1A (1555677_s_at)SETD2 (220946_s_at)COQ3 (221227_x_at)SPTLC2 (225095_at)POLR1E (218997_at)HMGXB4 (212596_s_at)CEP110 (242916_at)RBM10 (215089_s_at)ZNF292 (212368_at)GAR1 (219110_at)PCDH7 (205535_s_at)LOC100128223 /// TARDBP (221264_s_at)GPR126 (1553025_at)RUVBL2 (201459_at)G2E3 (223254_s_at)NIN (224303_x_at)APITD1 (213454_at)TAF9B (221616_s_at)CENPN (219555_s_at)CDCA2 (226661_at)HNRNPU (200593_s_at)FAM72A /// FAM72B /// FAM72D (225834_at)NCOA5 (225145_at)FLJ20674 (1553991_s_at)EXOSC3 (227912_s_at)HIRIP3 (204504_s_at)EZR (208622_s_at)−−− (227897_at)SIN3A (225135_at)CCNI (227299_at)SIAH1 (202981_x_at)CRMP1 (202517_at)RAB27A (209515_s_at)RCC1 /// SNHG3−RCC1 (206499_s_at)CENPO (226118_at)TMSB15B (214051_at)CBX5 (209715_at)MARCKS (213002_at)RRM2 (209773_s_at)PAICS (201014_s_at)DHFR (48808_at)KIAA0101 (202503_s_at)HNRNPR (208766_s_at)SAAL1 (225614_at)ASF1A (213561_at)PDE7A (224046_s_at)FAF1 (224217_s_at)EXOSC3 (227913_at)CDC5L (209055_s_at)POP7 (209482_at)GGA2 (208913_at)HNRNPR (208765_s_at)FAIM (220643_s_at)DHPS (207831_x_at)C1QBP (208910_s_at)FIGNL1 (222843_at)PHF17 (235024_at)SUPT16H (217815_at)FLJ32810 (230047_at)SART3 (209127_s_at)CXCL12 (209687_at)USP28 (231837_at)IPO5 (211955_at)NUP62 (202153_s_at)CSE1L (201112_s_at)ILF2 (200052_s_at)GSG2 (223759_s_at)DZIP3 (213186_at)PRKCA (215195_at)FANCE (220255_at)CALML4 (64408_s_at)GAS2L3 (235709_at)SKP2 (203626_s_at)C1orf112 (220840_s_at)SMC6 (218781_at)ALDH7A1 (208950_s_at)KIF21B (204411_at)EIF5 (208290_s_at)TUBB (209026_x_at)CPNE2 (225129_at)CHAF1A (214426_x_at)C13orf27 (213346_at)SCARA3 (223843_at)SNHG1 (224610_at)TMEM18 (225489_at)LOC100132077 (1559514_at)CENPV (226611_s_at)TDP1 (219715_s_at)FUT8 (1554930_a_at)LRP4 (212850_s_at)PTGS2 (1554997_a_at)−−− (227368_at)ITPRIP (225582_at)SHMT2 (214095_at)RCC2 (224578_at)DDX11 (208159_x_at)−−− (1557780_at)DDX11 (208149_x_at)CTCF (202521_at)ANKRD13A (224810_s_at)−−− (242073_at)DCLRE1C (222233_s_at)MRPS15 (226296_s_at)−−− (238670_at)SAE1 (217946_s_at)MFF (222832_s_at)ACTR5 (219623_at)DNALI1 (205186_at)C1orf77 (202559_x_at)SNCAIP (237833_s_at)TGIF2 (216262_s_at)ZWINT (204026_s_at)POLA1 (204835_at)MND1 (223700_at)RFC4 (204023_at)−−− (229129_at)DLGAP5 (203764_at)USP1 (202413_s_at)CCNI (208656_s_at)SOCS2 (203372_s_at)C5orf13 (201309_x_at)RAD51AP1 (204146_at)BRIP1 (221703_at)ZNF141 (206931_at)HAS2 (206432_at)DSG2 (1553105_s_at)CENPO (219472_at)DLG3 (212728_at)RBBP4 (225396_at)NR2C2AP (226839_at)−−− (227531_at)PATL1 (235234_at)SSFA2 (229744_at)ZNF83 (236429_at)GPR161 (235961_at)MASTL (228468_at)CCDC109B (218802_at)TTMA (229523_at)MLX (213708_s_at)ZWILCH (218349_s_at)TCERG1 (202396_at)GPI /// LOC100133951 (208308_s_at)TPR (1557227_s_at)HYI (223622_s_at)FAM13A (1569025_s_at)H2AFV (202487_s_at)−−− (240421_x_at)CDT1 (209832_s_at)IMPDH2 (201892_s_at)KIF22 (202183_s_at)TEAD4 (204281_at)CHTF18 (226569_s_at)TGS1 (238346_s_at)C11orf9 (204073_s_at)IFI16 (208965_s_at)MCM8 (233560_x_at)OIP5 (213599_at)NASP (242918_at)−−− (236648_at)RUVBL2 (1559946_s_at)SYNE2 (243841_at)PRPF19 (203103_s_at)PTPRF (200635_s_at)AMOTL1 (235277_at)TBL1X (201869_s_at)XRCC1 (203655_at)RAD54L (204558_at)TGS1 (236371_s_at)MLX (210752_s_at)CCNF (204827_s_at)NRP1 (210510_s_at)FOXP1 (224838_at)C4orf21 (231204_at)MED1 (225452_at)SFN (33323_r_at)WNK4 (229158_at)NUCKS1 (222424_s_at)LY6K (223687_s_at)HOXA7 (235753_at)MCM4 (212142_at)HIST1H2AJ (208583_x_at)KCNJ8 (205304_s_at)NUDCD2 (226642_s_at)TK1 (202338_at)BLM (205733_at)ASF1B (218115_at)NEFH (33767_at)HIST1H3F (208506_at)TEAD2 (226408_at)WDR51A (234749_s_at)SNRNP40 (215905_s_at)−−− (1558750_a_at)DLG3 (212729_at)HSPB11 (203960_s_at)KLHL23 (213610_s_at)LOC100126784 (240407_at)MRPS27 (212145_at)SMAP2 (225282_at)ARHGAP19 (37577_at)RBL1 (1555004_a_at)FH (214170_x_at)−−− (230714_s_at)SAC3D1 (205449_at)C3orf55 (238969_at)CEP57 (209862_s_at)POLQ (207746_at)LOC100133109 (213826_s_at)CAMK4 (210349_at)RICS (229648_at)MEX3B (223627_at)−−− (235971_at)TCF3 (213811_x_at)ITPK1 (210740_s_at)NOP58 (223096_at)SMEK2 (222270_at)PNN (212037_at)GNB4 (225710_at)NID1 (202007_at)GREM1 (218469_at)PDE7B (243438_at)MARCKS (201669_s_at)MDFIC (211675_s_at)MTHFD2 (201761_at)SMARCC1 (201074_at)HNRNPA3 /// HNRNPA3P1 (211931_s_at)GALNT7 (218313_s_at)FAM33A (225684_at)PATL1 (225468_at)SP3 (213168_at)ETS1 (224833_at)CEP57 (203494_s_at)PCM1 (214118_x_at)RBM12B (51228_at)TPM4 (209344_at)BEND6 (1568820_a_at)CA12 (210735_s_at)NAP1L1 (208753_s_at)−−− (215450_at)IRF2BP2 (224570_s_at)−−− (232667_at)PATZ1 (209431_s_at)TUBB (212320_at)HNRNPD (209330_s_at)PTGES3 (200627_at)CBX3 (201091_s_at)SFRS3 (208672_s_at)NFYB (218128_at)FST (226847_at)HNRNPA3 /// HNRNPA3P1 (211933_s_at)HNRPDL (209067_s_at)KLF12 (229881_at)UTP18 (203721_s_at)ZBTB44 (226148_at)−−− (227452_at)GTF3A (201338_x_at)ARHGAP11A (204492_at)ECT2 (219787_s_at)FBXO11 (203255_at)SEH1L (221931_s_at)PDK1 (226452_at)CTDSPL2 (223271_s_at)CACYBP (201381_x_at)SAP30 (204900_x_at)MEIS1 (204069_at)TNFRSF19 (224090_s_at)YEATS4 (218911_at)ALMS1 (214220_s_at)TES (202720_at)SFPQ (201586_s_at)PLEKHA2 (238013_at)LRIG3 (226908_at)PPP1CC (200726_at)PSIP1 (205961_s_at)BNIP3 (201849_at)LSM14A (212131_at)UBA6 (222601_at)PDE4D (210836_x_at)PDE4D (210837_s_at)SMAD4 (202527_s_at)PDLIM5 (213684_s_at)EPB41L3 (212681_at)−−− (207688_s_at)SNHG5 /// SNORD50A /// SNORD50B (244669_at)LOC203274 (232034_at)CDC42EP4 (214721_x_at)DNTTIP1 (224825_at)INSR (213792_s_at)KIAA0406 (212898_at)KPNB1 (208975_s_at)OSBPL9 (218047_at)CREBZF (202978_s_at)ZNF747 (238606_at)UBTD2 (224827_at)PRKDC (208694_at)RBM17 (224781_s_at)DCHS1 (222101_s_at)STXBP6 (220994_s_at)FOSL2 (228188_at)ZNF33A (231864_at)ERBB2IP (217941_s_at)FAM119A (235177_at)CCDC123 (1554512_a_at)PRPSAP1 (202529_at)PTBP2 (218683_at)ZMYM4 (202051_s_at)GREM1 (218468_s_at)VEZF1 (202171_at)TUBGCP3 (203690_at)GPM6B (209167_at)NOL9 (218754_at)NMI (203964_at)NUDCD1 (225438_at)NUDT21 (202697_at)FKBP5 (224856_at)RNF219 (219303_at)C16orf61 (218447_at)G2E3 (223256_at)C14orf145 (244033_at)ZNF93 (208119_s_at)KIF2A (203087_s_at)NPM1 (221923_s_at)CENPI (214804_at)KIAA0528 (212943_at)NIP7 (219031_s_at)−−− (227545_at)DBF4 (204244_s_at)LDB2 (206481_s_at)H2AFX (205436_s_at)PTMA (200772_x_at)SNRPB2 (202505_at)ARL6IP1 (211935_at)XRCC5 (208643_s_at)FAM178A (203481_at)C12orf48 (227928_at)DTL (218585_s_at)SKP2 (210567_s_at)TMPO (203432_at)CENPI (207590_s_at)SET (40189_at)C9orf40 (222781_s_at)C13orf34 (219544_at)POLD3 (212836_at)FAM101B (226905_at)POLR1D (218258_at)HAUS1 (225297_at)SMC3 (209259_s_at)DLEU2 /// DLEU2L (215629_s_at)PHF19 (225533_at)−−− (214148_at)FIGNL1 (1552921_a_at)XRCC6 (200792_at)H2AFV (212206_s_at)RRS1 (209567_at)−−− (225405_at)−−− (1554825_at)RNF2 (205215_at)−−− (236277_at)RFFL (1552651_a_at)ARMC8 (1555279_at)TCF3 (210776_x_at)METAP1 (212673_at)SIP1 (205063_at)NARG2 (218713_at)LOC728554 /// THOC3 (224623_at)TRPC3 (210814_at)C16orf53 (231878_at)TSPAN5 (225387_at)EZR (208623_s_at)FAM98B (225086_at)SDCCAG10 (223337_at)PPP4R1 (1563690_at)−−− (231064_s_at)FOXP1 (223287_s_at)CLN6 (1567080_s_at)−−− (235589_s_at)COL16A1 (204345_at)ALG10 (1552304_at)−−− (1570329_at)DYRK2 (202970_at)FLJ20674 (226485_at)ARHGDIB (1555812_a_at)ZFP161 (208199_s_at)−−− (232344_at)HNRNPUL2 (222264_at)NRF1 (204652_s_at)PTPN18 (203555_at)TRAIP (205598_at)DYRK2 (202971_s_at)MTF2 (203345_s_at)ADAMTSL1 (1552808_at)NDE1 (222625_s_at)−−− (223932_at)−−− (232095_at)IPO11 (222659_at)LOC730101 (213248_at)RIF1 (236620_at)HDGFRP3 (228266_s_at)PAIP1 (209064_x_at)PRMT3 (213320_at)HVCN1 (226879_at)PRKCA (1560074_at)PRKD3 (222565_s_at)FAF1 (218080_x_at)RAB31 (217764_s_at)THAP10 (219596_at)SENP1 (226619_at)GEM (204472_at)TFAM (203177_x_at)NUP50 (213682_at)BCCIP (218264_at)NIN (225921_at)ZCRB1 (225394_s_at)EXOSC9 (205061_s_at)NOLC1 (211951_at)PRPF38A (223230_at)CNOT7 (218250_s_at)MTHFD1 (202309_at)MSH6 (202911_at)DHX15 (201386_s_at)PRPF4 (209161_at)MRPL35 (222775_s_at)−−− (213574_s_at)COIL (203654_s_at)GJB2 (223278_at)CTNNAL1 (202468_s_at)PUS7L (221025_x_at)CXorf26 (223294_at)FAM54A (234945_at)HSPBAP1 (219284_at)CKAP5 (212832_s_at)CCHCR1 (37424_at)DERA (218102_at)ANP32A (201038_s_at)NUP205 (212247_at)FH (203033_x_at)LOC439949 (232001_at)ABCC9 (208562_s_at)SART3 (200069_at)HEATR1 (218594_at)DOPEY2 (205248_at)RHEB (227633_at)ID4 (226933_s_at)SRGAP1 (233888_s_at)ARHGAP19 (212738_at)GINS4 (211767_at)NUP85 (218014_at)NAT10 (217884_at)SIP1 (211114_x_at)PPP2R1B (202883_s_at)ID4 (209291_at)TWIST2 (229404_at)LOC81691 (215215_s_at)PPWD1 (213483_at)FASTKD3 (219200_at)FANCM (234733_s_at)URB2 (205284_at)GEMIN6 (219539_at)ZC3H4 (213390_at)GART (212378_at)THOC1 (204064_at)EMP2 (204975_at)BAZ1B (208445_s_at)TAF9B (226037_s_at)UMPS (202706_s_at)UBAP2L (201377_at)FUT4 (209892_at)ENPP2 (209392_at)EXOSC10 (207541_s_at)TNFRSF1B (203508_at)ZFP1 (226807_at)NR2F2 (229092_at)NOLC1 (205895_s_at)PAK1IP1 (218886_at)GLE1 (225371_at)OXTR (206825_at)CCDC66 (228122_at)GPATCH2 (242224_at)PCM1 (209997_x_at)−−− (235793_at)NCBP1 (209520_s_at)CREB1 (204312_x_at)NARG1L (219378_at)RBM15 (219286_s_at)DKC1 (201479_at)SYNJ2 (212828_at)TTC27 (218710_at)−−− (229844_at)C17orf85 (218896_s_at)TSHZ1 (223282_at)CASP6 (211464_x_at)SLC6A15 (240419_at)−−− (244664_at)AP4S1 (210278_s_at)ZZZ3 (229325_at)C17orf51 (228146_at)KRT19 (201650_at)POLB (203616_at)−−− (238719_at)KIAA0323 (212355_at)CNOT6 (222476_at)INSIG1 (201627_s_at)−−− (1560968_at)CA12 (214164_x_at)USP31 (226033_at)NFYB (218127_at)ZNF382 (1557260_a_at)HDHD1A (203974_at)−−− (234704_at)−−− (238895_at)CC2D2A (234936_s_at)ANKRD20A1 /// ANKRD20A2 /// ANKRD20A3 /// ANKRD20A4 /// C21orf81 /// LOC100132733 /// LOC284232 /// LOC643187 /// LOC647595 /// LOC653436 /// LOC727770 /// LOC728783 (1569607_s_at)ZSCAN12 (206507_at)EED (209572_s_at)PPIH (204228_at)H3F3B (211997_x_at)GJC1 (228563_at)MCAM (211042_x_at)SCLT1 (1569190_at)−−− (1557804_at)B3GALNT1 (211812_s_at)GPD2 (211613_s_at)NIP30 (223406_x_at)ANKHD1 (219081_at)−−− (217426_at)E2F8 (219990_at)ORC1L (205085_at)PCBP2 (204031_s_at)−−− (229525_at)CELSR2 (36499_at)PMF1 (202337_at)POLR2D (214144_at)−−− (236723_at)PHF20L1 (1554472_a_at)WDYHV1 (219060_at)USP13 (226902_at)PATL1 (235235_s_at)LIG3 (204123_at)PEG10 (212092_at)SEPHS1 (208941_s_at)NFIA (224976_at)FAM111B (1557128_at)ILF3 (208931_s_at)KIFC1 (209680_s_at)CDKN2C (211792_s_at)SFRS7 (214141_x_at)B3GALNT1 (223374_s_at)MRPL48 (218281_at)GMPS (214431_at)PITX2 (207558_s_at)AP4S1 (210277_at)CTPS2 (219080_s_at)SNAP25 (202507_s_at)COQ3 (223515_s_at)MGC12982 (224456_s_at)C1orf135 (220011_at)HNRNPR (232004_at)KIAA0391 (202713_s_at)WDR89 (244038_at)UPF3B (218757_s_at)CCDC52 (234995_at)AASS (210852_s_at)CSTF2T (212905_at)−−− (236350_at)N4BP2L2 (202259_s_at)LOC731602 /// METT11D1 (223528_s_at)RNF34 (236288_at)PTBP2 (1554614_a_at)PAK1 (209615_s_at)−−− (1557419_a_at)FUS (231108_at)ITGA2B (216966_at)ZFYVE20 (1569714_at)C11orf41 (214772_at)LOC389906 (1564639_at)DHPS (202802_at)−−− (1556964_s_at)DNAJA4 (1554333_at)−−− (239451_at)PRPF18 (232473_at)XRCC5 (232633_at)NSD1 (219084_at)IQCC (206650_at)−−− (222282_at)ZNF280D (239107_at)DNAJC8 (212491_s_at)ATP8B1 (238055_at)LRPPRC (1557360_at)UNC84B (212144_at)MAZ (207824_s_at)WWC1 (229180_at)SLC16A1 (1557918_s_at)RBM14 (1555639_a_at)PTPRF (200637_s_at)TBX3 (229565_x_at)NLE1 (203867_s_at)PDE4D (211840_s_at)−−− (1557623_at)DZIP1L (239785_at)−−− (240212_at)PRDM2 (216433_s_at)SRGAP1 (1555876_at)SFRS15 (243759_at)PVRL1 (211846_s_at)LOC339803 (227941_at)PWP2 (209336_at)SRGAP1 (1569269_s_at)ZDHHC6 (218249_at)−−− (242133_s_at)LOC390940 (213556_at)−−− (238371_s_at)ZNRF1 (223382_s_at)APEX2 (204408_at)VPRBP (204376_at)DAXX (201763_s_at)C14orf143 (214264_s_at)C9orf126 (214997_at)−−− (238501_at)−−− (230085_at)CXorf15 (227520_at)SLC5A6 (204087_s_at)MARVELD2 (235141_at)LY6K (223688_s_at)−−− (240529_at)−−− (236215_at)LOC100272216 (213089_at)TLE3 (212769_at)RUFY2 (219957_at)C16orf88 (213235_at)WDR1 (240282_at)PBRM1 (223899_at)ZIK1 (235773_at)SLC16A7 (210807_s_at)NUP50 (222583_s_at)MED1 (203496_s_at)SFRS8 (202775_s_at)−−− (222342_at)ARAP2 (214102_at)PRELID2 (235828_at)CARD10 (210026_s_at)CAMTA1 (227328_at)ANKRD35 (231118_at)−−− (1557797_a_at)TCTE3 (1557945_at)ZNF506 (1568720_at)LOC728411 (1558640_a_at)−−− (227959_at)UNK (226376_at)−−− (1558714_at)−−− (215515_at)−−− (233964_at)−−− (231428_at)PDK3 (206347_at)−−− (242343_x_at)DHX9 (212105_s_at)PDAP1 (202290_at)−−− (238395_at)KHSRP (227555_s_at)LOC100129656 (221639_x_at)SP4 (206663_at)SMARCC1 (201073_s_at)CASP2 (209811_at)−−− (235102_x_at)−−− (226812_at)HN1L (216031_x_at)H2AFX (212524_x_at)CCDC117 (235330_at)HNRNPU (216855_s_at)PRMT1 (206445_s_at)−−− (239238_at)CLSPN (219621_at)MGMT (204880_at)APH1A (1554417_s_at)EEF1D (213087_s_at)RAB8B (222846_at)NHS (228933_at)SERP2 (228044_at)MGA (1564640_at)IRF2BP2 (224572_s_at)−−− (236578_at)ATF7IP2 (228381_at)CCDC152 (237475_x_at)GUSB (230125_at)SLC12A7 (218066_at)C1orf163 (222883_at)ITGB8 (242982_x_at)TOMM22 (217960_s_at)BAHCC1 (219218_at)TAF4 (208545_x_at)MAGOH (210092_at)UBE2G2 (232755_at)ZNF680 (229533_x_at)COL9A3 (204724_s_at)MARCKS (201668_x_at)TRA2B (210180_s_at)MED28 (228992_at)−−− (233626_at)−−− (236000_s_at)RMND5B (213297_at)hCG_1644608 /// SET (215780_s_at)POLE (216026_s_at)NR2F2 (209119_x_at)H2BFS (208579_x_at)GRPEL2 (238427_at)GPX4 (201106_at)RPS2 (203107_x_at)NUP62 (207740_s_at)APPL1 (222538_s_at)SMARCC1 (201072_s_at)FANCB (1557218_s_at)PTBP1 (216306_x_at)UBE2I (213535_s_at)HIST1H4J (214463_x_at)MRPS15 (221437_s_at)C1orf77 (209927_s_at)−−− (239036_at)−−− (232363_at)−−− (235446_at)LOC100129656 (216868_s_at)TCF3 (213732_at)PRO2012 (1553546_at)hCG_2008140 (227593_at)LOC440354 /// LOC595101 /// LOC641298 /// LOC728423 /// LOC729513 /// SMG1 (244766_at)CREBZF (213584_s_at)HELB (1552788_a_at)ANKRD10 (226663_at)C5orf44 (236526_x_at)NPHP1 (238844_s_at)−−− (240165_at)LOC100129034 (244823_at)PUS7L (229751_s_at)C6orf182 (232152_at)−−− (1563331_at)LOC727751 /// LOC727849 /// LOC80154 (223327_x_at)GMDS (204875_s_at)GART (230097_at)−−− (1567303_at)−−− (243514_at)JAM2 (219213_at)−−− (232784_at)SFRS4 (239512_at)PAQR8 (227626_at)ZC4H2 (234809_at)MID1IP1 (218251_at)ZNF678 (232028_at)MICAL2 (236475_at)−−− (229434_at)EFS (210880_s_at)U2AF1 (231904_at)AP1G2 (201613_s_at)−−− (1561886_a_at)SFRS4 (241245_at)−−− (1557418_at)LPP (243874_at)LOC388152 /// LOC727751 /// LOC727849 /// LOC80154 (220602_s_at)LOC727820 (227384_s_at)−−− (238945_at)LOC653506 /// METRNL (225955_at)−−− (1556806_at)−−− (242089_at)−−− (1557519_at)−−− (239131_at)REL (206036_s_at)H1FX (231004_s_at)−−− (224214_at)RALY (201271_s_at)POLR2I (212955_s_at)−−− (236962_at)PAFAH1B3 (203228_at)MRPS16 (218046_s_at)MYO19 (236022_at)SNRPB (213175_s_at)RPS9 (217747_s_at)PCM1 (209996_x_at)MDM4 (235162_at)ARID1A (218917_s_at)NR1H3 (217370_x_at)−−− (226138_s_at)PCBP1 (208620_at)C5orf13 (230424_at)GJC1 (243502_at)COMMD4 (206441_s_at)PRIM2 (215708_s_at)EZR (217230_at)ZNF107 (1560854_s_at)−−− (228049_x_at)MTPAP (229676_at)−−− (213789_at)CPSF7 (217866_at)PGAP1 (244321_at)MDM4 (225740_x_at)SLC2A4RG (218494_s_at)−−− (234745_at)−−− (229713_at)−−− (229558_at)CALM3 (200622_x_at)FOXN2 (206708_at)XRCC6BP1 (227678_at)PRPF4 (209162_s_at)API5 (214959_s_at)ZNF85 (1554445_at)ING2 (213544_at)RQCD1 (213903_s_at)RALGPS2 (242458_at)−−− (206532_at)TAGLN2 (200916_at)CDH2 (203441_s_at)SFRS6 (206108_s_at)FUSIP1 /// LOC642558 (213594_x_at)LIN7A (206440_at)EXOSC2 (214507_s_at)TAF2 (1554721_a_at)GAS5 (235712_at)GLRX2 (219933_at)TOMM40 (202264_s_at)RPP30 (203436_at)OSGEPL1 (230032_at)DIS3 (214194_at)RBM8A (222443_s_at)DPF3 (236442_at)TTLL12 (1552257_a_at)CWF19L1 (233568_x_at)TADA2L (210537_s_at)ABCE1 (201872_s_at)POLD2 (201115_at)RQCD1 (213098_at)WDFY2 (227490_at)CWF19L1 (218787_x_at)CAMTA1 (225693_s_at)C21orf109 (1553608_a_at)−−− (242673_at)LRRFIP2 (232704_s_at)ZNF473 (213130_at)−−− (226190_at)NCOA5 (234471_s_at)−−− (236797_at)−−− (1560926_at)TTC30B (1554588_a_at)−−− (243740_at)PPAN (221649_s_at)USP45 (224441_s_at)−−− (215006_at)ATL2 (1553603_s_at)−−− (235474_at)SPATA6 (220299_at)RFC5 (203210_s_at)MDM4 (225742_at)−−− (239823_at)−−− (238178_at)SLC16A7 (241866_at)PNRC2 (222406_s_at)WDR4 (235551_at)−−− (232535_at)LOC440288 (238511_at)LOC100132707 (1558527_at)HNRNPC (200751_s_at)C9orf80 (223559_s_at)NUP62 (236505_at)LOC100129884 (234757_at)−−− (232324_x_at)−−− (207731_at)SMCHD1 (241620_at)−−− (229569_at)ZSCAN12 (217098_s_at)C14orf43 (225980_at)ZNF43 (206695_x_at)DLG1 (217208_s_at)−−− (1563054_at)−−− (214349_at)ZSCAN2 (220516_at)SRRT (201679_at)−−− (230703_at)EBP (213787_s_at)RBM17 (225751_at)NHLRC2 (244320_at)NUP188 (217601_at)−−− (1563903_x_at)C2orf68 (238768_at)ATP5G2 (208764_s_at)RPS2 (212433_x_at)−−− (1564151_at)CASP2 (226036_x_at)FANCD2 (1568889_at)FH (203032_s_at)SYNJ2 (1555009_a_at)C19orf48 (224468_s_at)ACER3 (222689_at)MDM4 (236814_at)LOC731884 (217520_x_at)TMEM201 (228671_at)UCP2 (208997_s_at)SNHG10 (238691_at)−−− (241063_at)−−− (243103_at)−−− (231827_at)ALG10B (238475_at)CCDC123 (1553732_s_at)TAF9B (228483_s_at)PM20D2 (229495_at)SLC8A1 (207053_at)ZNF182 (244024_at)GART (216990_at)GLMN (236924_at)−−− (240625_at)LOC286434 /// LOC389906 /// LOC729162 (222031_at)−−− (238193_at)FAM164A (205308_at)−−− (1568997_at)GART (217445_s_at)ZNF830 (226315_at)NNT (202784_s_at)C16orf63 (225088_at)ISY1 (223429_x_at)C15orf42 (230021_at)TIFA (238858_at)MYST3 (202423_at)NXT2 (209629_s_at)SEH1L (223225_s_at)−−− (230499_at)KCNRG (239098_at)ZNF236 (47571_at)TRIM55 (232721_at)−−− (229267_at)SIN3A (238189_at)TUBGCP3 (215739_s_at)RFX3 (238810_at)C10orf119 (217905_at)GSTCD (235387_at)EPCAM (201839_s_at)HAUS6 (222685_at)GPRIN1 (227975_at)LRRK1 (219441_s_at)DFFB (206752_s_at)−−− (225856_at)CRISPLD1 (223475_at)BCCIP (227896_at)CBX5 (242069_at)ERI1 (226416_at)ING2 (205981_s_at)ISCA2 (226007_at)CREB1 (214513_s_at)−−− (235027_at)FBXO45 (225100_at)MYC (202431_s_at)TMEM194A (212619_at)CD83 (204440_at)−−− (243023_at)ZNF19 (228958_at)SMU1 (218393_s_at)FAM110B (228790_at)GULP1 (215913_s_at)SNRPA (201770_at)ANKRD13A (238851_at)LIN9 (235039_x_at)BRI3BP (231810_at)CENPL (232065_x_at)CEP97 (219886_at)DNAJC22 (244193_at)CHD4 (201182_s_at)AKR1CL2 (1555220_a_at)−−− (215968_at)MCCC2 (209624_s_at)SV2A (203069_at)−−− (239376_at)−−− (231894_at)FNDC3A (241611_s_at)HNRNPUL2 (66053_at)SLC8A1 (241752_at)SGEF (233903_s_at)PRKD3 (211084_x_at)XRN2 (233878_s_at)STAT5B (205026_at)FLJ31958 (1553354_a_at)MATR3 (1558093_s_at)CASP2 (211140_s_at)−−− (242346_x_at)GPM6B (209170_s_at)CCDC144A /// CCDC144B /// CCDC144C /// LOC100134159 (1557366_at)ROD1 (207223_s_at)C22orf30 (216555_at)RPS2 (217466_x_at)FN3KRP (218210_at)SCLT1 (1569495_at)FBLN2 (203886_s_at)GALE (202528_at)DKC1 (216212_s_at)CLDN11 (206908_s_at)APCDD1L (235548_at)FST (204948_s_at)PRDM8 (239111_at)TEAD4 (41037_at)DCLK2 (227666_at)DDX18 (208895_s_at)DIDO1 (218325_s_at)PCNT (233387_s_at)TFAM (208541_x_at)EID3 (231292_at)HIST1H3G (208496_x_at)FLJ45482 (1565786_x_at)CDC25C (216914_at)THOC4 (226320_at)LOC728377 (228596_at)NFIA (224970_at)RANBP1 (202483_s_at)CHAF1A (229808_at)NUDT1 (204766_s_at)HIST1H1E (208553_at)BUB3 (229827_at)SMCHD1 (212577_at)CKAP5 (1555278_a_at)GTSE1 (211040_x_at)−−− (216856_s_at)GJC1 (208460_at)U2AF1 (202858_at)LMNB2 (216952_s_at)HIST1H4L (214562_at)PEX13 (1558164_s_at)SGK493 (225380_at)TK1 (1554408_a_at)FBL (211623_s_at)ENY2 (218482_at)HIST1H2BG (215779_s_at)CDK2 (211804_s_at)H3F3B (209069_s_at)AXL (202685_s_at)TP53 (211300_s_at)MAT2A (200769_s_at)DTYMK (203270_at)PRKDC (210543_s_at)ADAMTS6 (220866_at)THOC4 (226319_s_at)C6orf150 (1559051_s_at)ZNF253 (242919_at)CPSF4 (206688_s_at)MAD2L1 (1554768_a_at)SFPQ (226898_s_at)HYI (221435_x_at)−−− (243840_at)HIST1H3B (208576_s_at)HIST1H2AE (214469_at)RFWD3 (218564_at)SMC3 (209257_s_at)SFPQ (201585_s_at)CCDC58 (235244_at)LASS6 (235463_s_at)HIST1H1D (214537_at)HIST1H2BI (208523_x_at)SLC7A1 (212290_at)RCL1 (222666_s_at)SNRNP25 (218493_at)SMARCB1 (212167_s_at)MRPL47 (223481_s_at)TSPAN5 (209890_at)TCF3 (228052_x_at)MED1 (203497_at)EIF2C1 (222576_s_at)RAD18 (224200_s_at)SEPT9 (207425_s_at)HNRNPD (239040_at)C20orf196 (243507_s_at)FAM46C (220306_at)−−− (241958_at)FNTB (204764_at)UCP2 (208998_at)HEATR1 (1556348_at)NUPL1 (223984_s_at)JAK3 (227677_at)TEAD2 (243766_s_at)JUB (1553764_a_at)MIDN (225954_s_at)LOC728264 (231987_at)HIST2H4A /// HIST2H4B (207046_at)ZNF114 (1552947_x_at)−−− (220494_s_at)−−− (239364_at)DOCK11 (238356_at)SDC4 (202071_at)MRPL22 (218339_at)−−− (241936_x_at)FAM161A (242584_at)IRAK1BP1 (238599_at)−−− (244441_at)CEP152 (238535_at)ZNF783 (78495_at)−−− (227356_at)TMEM71 (238429_at)PCIF1 (222044_at)DYRK1A (211541_s_at)FAM62B (1555829_at)HMGA2 (1567223_at)HPS3 (231121_at)−−− (1554599_x_at)KITLG (207029_at)MAB21L2 (210302_s_at)MDM4 (205655_at)−−− (238410_x_at)RPA1 (201529_s_at)CCBL2 (227748_at)PFTK1 (211502_s_at)CUGBP2 (202157_s_at)RAD51L3 (37793_r_at)RYK (214172_x_at)C3orf31 (226815_at)KLF12 (208467_at)TRIO (208178_x_at)ZBTB26 (1554973_a_at)MYO10 (216222_s_at)MIB1 (224720_at)MARCKSL1 (200644_at)SPATA5 (241546_at)CCDC77 (224521_s_at)UCHL5 (220083_x_at)UBE2T (223229_at)HELLS (223556_at)MEIS1 (1559477_s_at)FAM26F (229543_at)−−− (244423_at)DNMT3A (222640_at)MBOAT1 (227379_at)NUP155 (206550_s_at)CDK5RAP2 (220935_s_at)ETS1 (1555355_a_at)HOXA2 (214457_at)ZNF670 (223898_at)CCDC45 (225705_at)PRKD3 (218236_s_at)RBMS3 (238447_at)HAUS5 (213053_at)NUCKS1 (223661_at)TRA2B (200892_s_at)UBA6 (218340_s_at)NET1 (201830_s_at)IPO5 (211953_s_at)TTC39C (230747_s_at)API5 (201686_x_at)TCF20 (215511_at)PTK7 (1555324_at)MBP (225408_at)ZNF280C (235520_at)MED13L (242911_at)−−− (239729_at)NAB2 (216017_s_at)LANCL1 (202019_s_at)PRIM2 (1554885_a_at)PLCXD1 (218951_s_at)FAM60A (223038_s_at)RGS12 (1555022_at)B9D2 (219766_at)LIMD1 (218850_s_at)−−− (227051_at)TSN (201504_s_at)SLC8A1 (1561614_at)LIFR (225571_at)MTMR2 (203212_s_at)FANCA (203806_s_at)FAM49B (217916_s_at)HDGFRP3 (221976_s_at)ACTL6A (202666_s_at)MTHFD2L (238762_at)MTPAP (222794_x_at)LOC100129502 (228791_at)GGCT (215380_s_at)SLC24A1 (206081_at)ZNF519 (1557283_a_at)ALG10B (242900_at)EIF2C1 (218287_s_at)SSPN (204963_at)SEPP1 (201427_s_at)CASP1 (211367_s_at)APLN (222856_at)ZNF184 (213452_at)−−− (236462_at)SEPT13 (1569974_x_at)TRO (211701_s_at)ZNF639 (222624_s_at)−−− (241649_at)FAM162A (223193_x_at)TMEM14B (223133_at)GLTSCR2 (217807_s_at)RAB20 (219622_at)GABRA4 (208463_at)CDC10L (1556222_at)SART3 (209128_s_at)RGN (210751_s_at)−−− (233036_at)NUP160 (214963_at)HES1 (203395_s_at)CHAC2 (235117_at)NUP98 (210793_s_at)GSTM5 (205752_s_at)WASF1 (204165_at)DDX28 (203785_s_at)PDK3 (221957_at)BCL2L11 (225606_at)TADA2L (209938_at)SPSB1 (219677_at)EEPD1 (225630_at)GDF5 (206614_at)MARCH3 (213256_at)KREMEN1 (227250_at)−−− (235766_x_at)RERE (221643_s_at)MCCC2 (209623_at)NUP214 (202155_s_at)ZNF766 (227284_at)CSPG4 (204736_s_at)PPP1R13L (218849_s_at)MSRB2 (230575_at)−−− (235764_at)AKR1CL2 (223856_at)RASIP1 (220027_s_at)EP400 (212376_s_at)−−− (241865_at)−−− (229193_at)MGC45800 (232446_at)−−− (243253_at)ADAMTS2 (214454_at)RNF130 (1563975_at)−−− (227554_at)−−− (242471_at)−−− (1561966_at)MLLT6 (224784_at)N−PAC /// SEPT6 (212414_s_at)ZNF853 (232884_s_at)−−− (232903_at)ANXA3 (209369_at)LOC154761 (227868_at)HNRNPA1L2 (238696_at)NPHP1 (238843_at)NENF (214075_at)TSEN15 (230257_s_at)EMILIN2 (224374_s_at)−−− (238040_at)−−− (230689_at)FAM127B (217948_at)−−− (241786_at)NUP54 (231301_at)COMMD2 (223491_at)TCF7L2 (212759_s_at)RASD1 (223467_at)LOC285943 (1562640_at)MEX3A (226346_at)−−− (241797_at)−−− (239841_at)−−− (233058_at)−−− (216121_at)KIAA1731 (1565829_at)LOC388796 /// SNORA71B (1568249_at)−−− (235207_at)IL17RD (227997_at)ZNRF1 (223383_at)PFKFB4 (228499_at)LOC220930 (229090_at)−−− (237105_at)PDGFA (216867_s_at)CORO1A (209083_at)−−− (1569339_s_at)FCF1 (240928_at)−−− (235801_at)HMGA2 (1558682_at)FANCF (218689_at)ACER3 (222687_s_at)IQCB1 (205995_x_at)PCDH7 (228640_at)C11orf75 (219806_s_at)CUL2 (203078_at)OAS3 (218400_at)ZNF619 (1552836_at)−−− (238758_at)C11orf30 (219012_s_at)−−− (220033_at)PAIP1 (208051_s_at)MIS12 (221559_s_at)LANCL1 (202020_s_at)PRPF40A (213729_at)NUDCD1 (225439_at)CRLS1 (241741_at)USP31 (227256_at)KIAA1712 (231850_x_at)APOO (221620_s_at)EIF2B2 (202461_at)KLHL15 (226370_at)SETD6 (1554555_a_at)MICALL1 (55081_at)PACRGL (235259_at)HDGFRP3 (209526_s_at)PPP4R1 (201594_s_at)ECSCR (228339_at)KLF13 (225390_s_at)CSNK2A2 (224922_at)ATP11C (226785_at)C5orf25 (228805_at)MCM9 (219673_at)GNPDA1 (202382_s_at)ATL2 (222700_at)ASF1A (203427_at)LMCD1 (218574_s_at)CREM (228092_at)ETV6 (225764_at)−−− (239834_at)RIN1 (205211_s_at)ACAD9 (224160_s_at)NVL (207877_s_at)ALG9 (228817_at)DENND1A (226849_at)TMEM70 (219448_at)C11orf41 (244584_at)LIN52 (228583_at)TOE1 (204080_at)FUT4 (209893_s_at)−−− (238414_at)C2orf67 (215046_at)REXO2 (235045_at)INSR (226450_at)NCRNA00094 (213788_s_at)C21orf58 (1559439_s_at)RP5−1022P6.2 (230492_s_at)VCL (200930_s_at)C15orf42 (232475_at)−−− (227505_at)SEMA4C (219039_at)ZNF507 (235618_at)DBF4B (206661_at)FLJ35934 (1564383_s_at)KIAA1967 (225187_at)LOC727751 /// LOC727849 /// LOC80154 (223326_s_at)PPIE (202494_at)STAT5A (203010_at)ZNF775 (228226_s_at)CISD2 (226689_at)SDCCAG10 (1555495_a_at)−−− (236610_at)ADORA2B (205891_at)CNOT6L (227119_at)LOC339400 (241014_at)ZNF551 (211721_s_at)ARL5A (226617_at)SFRS3 (235324_at)C8orf45 (1552359_at)ZNF26 (219595_at)ALG13 (219015_s_at)C2orf69 (227973_at)UHRF2 (225610_at)C20orf191 /// LOC100133918 /// NCOR1 (200855_at)SETD2 (241458_at)SETD6 (219751_at)DMC1 (208386_x_at)ZBED1 (1554821_a_at)CSTF2T (212901_s_at)VPRBP (204377_s_at)ZAK (1555259_at)−−− (237841_at)SUZ12 /// SUZ12P (213971_s_at)FAM158A (219203_at)TDRD3 (1569069_s_at)NRP2 (211844_s_at)TRAC (209670_at)PSAT1 (220892_s_at)ARID3B (218964_at)FMNL2 (242665_at)−−− (1558365_at)−−− (242677_at)PTPLAD2 (244050_at)C19orf2 (211563_s_at)TGS1 (219231_at)LAYN (1556886_a_at)PRKRIR (209323_at)TPR (201730_s_at)CHD1 (204258_at)GPD2 (210007_s_at)KIF18A (221258_s_at)HIST1H2AM (214481_at)UTRN (225093_at)EVI1 (221884_at)C18orf10 (213617_s_at)SESTD1 (226763_at)KHDRBS3 (209781_s_at)SP1 (224754_at)FBXO17 (220233_at)TPR (201731_s_at)EML4 (223068_at)HNRNPF (201376_s_at)LOC284900 (244189_at)PPT1 (200975_at)RHOBTB3 (202975_s_at)FANCM (1554277_s_at)TNFRSF19 (223827_at)LOC100132707 (1569898_a_at)−−− (1562611_at)ALDH7A1 (208951_at)BNC2 (238478_at)SUZ12 (212287_at)NME7 (219553_at)BUD13 (224504_s_at)LDLRAD3 (234985_at)ING3 (205070_at)AMOTL1 (228840_at)RNF138 (218738_s_at)POGK (218229_s_at)−−− (227432_s_at)MAT2A (200768_s_at)CCNJ (229091_s_at)SENP7 (220735_s_at)TSR1 (218156_s_at)SRR (219204_s_at)PPAT (209434_s_at)ZC3H13 (212402_at)TRAF3IP3 (231932_at)ANKRD32 (223542_at)MSL2 (218733_at)ERBB2IP (222473_s_at)SMCHD1 (212579_at)DDX18 (208896_at)NUP107 (218768_at)CENPE (205046_at)PSIP1 (210758_at)CENPN (228559_at)WDR51A (226355_at)EMP2 (225078_at)EML4 (220386_s_at)LDHB (201030_x_at)TNFAIP8 (210260_s_at)POSTN (210809_s_at)FAM129A (217967_s_at)CHD1L (212539_at)C11orf30 (222807_at)ANP32A /// LOC100128146 (201043_s_at)GOLM1 (217771_at)KDM1 (212348_s_at)SNX5 (229980_s_at)KDM2B (226215_s_at)PDS5B (204742_s_at)API5 (201687_s_at)RFC2 (1053_at)IFT57 (218100_s_at)EXOSC7 (212627_s_at)ZNF286A (1557684_at)ADNP2 (203322_at)SMC6 (236535_at)−−− (235134_at)UGP2 (232180_at)EFNB2 (202669_s_at)TRA2B (239447_at)−−− (237309_at)LOC442075 (237005_at)DUS4L (205761_s_at)C8orf46 (229430_at)LAS1L (208117_s_at)CCDC44 (221069_s_at)NIN (224304_x_at)BAG1 (211475_s_at)LOC100129592 (236609_at)RBM25 (212030_at)CBFB (202370_s_at)MLLT4 (238871_at)DDX46 (228039_at)EHHADH (205222_at)−−− (1556694_a_at)UTP14A (221514_at)CCDC125 (1553542_at)SFRS8 (202774_s_at)−−− (242152_at)PRPF8 (200000_s_at)NARG2 (235189_at)CSTF2 (204459_at)RGMB (242450_at)ODF2 (210415_s_at)C21orf91 (220941_s_at)ZNF681 (238962_at)ANKRD2 (221232_s_at)−−− (240152_at)C1orf59 (225841_at)LOC91431 (1565934_at)TBL1X (213400_s_at)LOC126661 (1559003_a_at)SFRS7 (213649_at)−−− (228987_at)GNB2L1 (222034_at)POU6F1 (205878_at)ADAMTS3 (214913_at)HEATR2 (1554761_a_at)COL3A1 (232458_at)−−− (235826_at)FBXO43 (236852_at)PPARG (208510_s_at)C10orf93 (1555573_at)−−− (1560433_at)−−− (227547_at)ZNF239 (206261_at)EXOC4 (235974_at)MYO19 (225947_at)RNPS1 (207939_x_at)SRGAP2 (213329_at)−−− (229004_at)−−− (242630_at)CDK5RAP2 (233540_s_at)ALDH18A1 (217791_s_at)−−− (235441_at)OXNAD1 (227686_at)FAF1 (239749_at)SUPT3H (206506_s_at)NBN (202906_s_at)ELP3 (221094_s_at)ATP5SL (1557759_at)−−− (216002_at)UNC5B (226899_at)RBM26 (215751_at)LOC339483 (228593_at)−−− (244719_at)PKNOX2 (222171_s_at)STAMBP (235361_at)FKBP11 (219118_at)GCET2 (235310_at)RBBP4 (239071_at)TNRC18 (229257_at)−−− (222366_at)−−− (217577_at)MMD (244523_at)GINS4 (235029_at)DYRK2 (202968_s_at)ENOSF1 (204142_at)FRMD5 (230831_at)TNFAIP6 (206026_s_at)F2RL1 (213506_at)−−− (244507_at)FKBP11 (219117_s_at)PA2G4 (214794_at)SFMBT1 (213370_s_at)RNFT2 (221908_at)−−− (243315_at)POT1 (204354_at)TMEM18 (225487_at)hCG_1771830 (1559275_x_at)−−− (229615_at)ZNRF2 (226261_at)GRIK2 (1560265_at)PTPRB (205846_at)−−− (243086_at)RSRC1 (235354_s_at)−−− (1554597_at)MCPH1 (1554155_at)SP3 (238035_at)ZNF660 (1561361_at)TIA1 (201450_s_at)IL1RAP (210233_at)CALU (238908_at)ITPRIPL1 (240037_at)LOC654433 (227474_at)−−− (237860_at)PPFIA4 (214978_s_at)SLC25A13 (229081_at)SLC17A9 (219559_at)−−− (237246_at)−−− (240076_at)DDX11 /// DDX12 /// LOC642846 (213378_s_at)MLLT10 (1563321_s_at)TTF1 (204771_s_at)UBA6 (222600_s_at)−−− (232058_at)CDCA7 (230060_at)CALML4 (221879_at)TTLL4 (203702_s_at)−−− (243305_at)ACSBG2 (221716_s_at)TRERF1 (233324_at)ZNF267 (219540_at)−−− (238612_at)−−− (230003_at)−−− (235123_at)−−− (236791_at)RASA2 (230669_at)PLAGL2 (202925_s_at)ZNF532 (225021_at)−−− (1569551_at)−−− (239404_at)OPA1 (214306_at)−−− (244393_x_at)−−− (240493_at)−−− (238139_at)−−− (229029_at)−−− (243691_at)−−− (239912_at)GABPB1 (204618_s_at)−−− (229342_at)GUSB (202605_at)NUDCD2 (226643_s_at)RAB27A (210951_x_at)SIP1 (211115_x_at)SMAD3 (218284_at)C11orf17 /// NUAK2 (220987_s_at)TRIO (209013_x_at)UGP2 (205480_s_at)G2E3 (223255_at)WBP11 (217821_s_at)FAM60A (220147_s_at)PBX1 (212148_at)ERO1L (222646_s_at)PHF10 (219126_at)CEP57 (203491_s_at)CTBP2 (201219_at)−−− (235890_at)−−− (233303_at)DIDO1 (227335_at)C21orf66 (1555125_at)ZNRD1 (228009_x_at)CEBPG (204203_at)ENOSF1 (213645_at)EFCAB3 /// LOC100133744 (1553392_at)FUBP1 (214094_at)PPIL2 (223999_at)RNF168 (1553127_a_at)−−− (1562476_at)TAF9B (221618_s_at)ILKAP (221548_s_at)LOC100129510 (1560163_at)−−− (237912_at)EIF3M (215190_at)−−− (237548_at)BPHL (205750_at)SLC7A5 (201195_s_at)RSRC1 (1555501_s_at)PAQR5 (220333_at)NAV2 (222598_s_at)NFYA (204108_at)C6orf162 (236178_at)−−− (242380_at)−−− (239372_at)UBA2 (229587_at)−−− (237903_at)−−− (1558522_at)LRRC58 (225479_at)NPR3 (219790_s_at)KIF21A (231875_at)LARS2 (204016_at)TMSB15B (1570039_at)C1orf84 /// KIAA0467 (1569709_at)MYEF2 (222772_at)FUS (215744_at)IL15 (205992_s_at)AP4S1 (235647_at)TRIM7 (223694_at)HNRPLL (225386_s_at)WDR70 (219193_at)EIF3M (240513_at)GUF1 (222770_s_at)C21orf66 (218515_at)C10orf2 (218590_at)TIA1 (201446_s_at)−−− (232528_at)PFTK2 (1552559_a_at)PTCD3 (228590_at)−−− (1559007_s_at)NFKB1 (209239_at)TGFBR1 (236561_at)KCTD15 (222664_at)NUP133 (202184_s_at)ZBTB44 (1554469_at)UBE2I (1558088_a_at)NAALADL1 (228424_at)RPL37A (213459_at)TRIM4 (1554287_at)NMT2 (205005_s_at)XPNPEP3 (227910_at)LARP2 (226750_at)KIAA1712 (228334_x_at)OLFML2A (213075_at)LIN9 (230365_at)MSH6 (240148_at)ZNF92 (1564963_x_at)−−− (213658_at)CNOT2 (217798_at)TSKU (218245_at)HDAC2 (242141_at)ALS2 (232184_at)TSHZ3 (223393_s_at)PGAP1 (213469_at)SMAD4 (202526_at)CEP70 (238154_at)RERE (200940_s_at)PLK2 (201939_at)−−− (236122_at)C3orf58 (226464_at)SEPT6 (214298_x_at)AUH (205052_at)STXBP6 (230560_at)SMAD1 (210993_s_at)A2M (217757_at)ZNF518A (204291_at)FMR1 (215245_x_at)LHFPL2 (212658_at)OTUD1 (226140_s_at)SHROOM3 (228400_at)LIF (205266_at)CTTNBP2 (232136_s_at)NRP2 (214632_at)−−− (239129_at)MED9 (218372_at)CEBPD (203973_s_at)DENND2D (221081_s_at)LXN (218729_at)JARID2 (203298_s_at)−−− (243016_at)−−− (234651_at)RAD1 (228535_at)C7orf31 (229146_at)SNAP25 (202508_s_at)WBP11 (217822_at)C17orf75 (203830_at)HEPH (203903_s_at)LOC400713 (232315_at)FANCD2 (1568891_x_at)TMTC4 (225666_at)MKX (239468_at)MICAL3 (212715_s_at)SENP7 (223444_at)−−− (1558103_a_at)BNC1 (206581_at)−−− (227004_at)LOC144481 (1559315_s_at)−−− (237512_at)TRIM34 /// TRIM6−TRIM34 (221044_s_at)MLH1 (202520_s_at)ENY2 (226776_at)QPCT (205174_s_at)LARS2 (34764_at)RAP2C (234344_at)SPATA5 (229075_at)RAP2C (218668_s_at)SSPN (226932_at)ZAK (222757_s_at)−−− (242228_at)CMC1 (228283_at)EPB41L4B (220161_s_at)BNC2 (243445_at)ZCCHC8 (218478_s_at)C17orf58 (226901_at)ADNP (201773_at)TRIM24 (204391_x_at)INSR (226216_at)BPTF (231953_at)SMC3 (1556925_at)ARGLU1 (227448_at)C5 (205500_at)PTCD3 (217895_at)ZBTB10 (219312_s_at)CASP1 (211366_x_at)FAM38B (222908_at)−−− (234144_at)−−− (236828_at)−−− (230139_at)YWHAH (236559_at)CASP1 (211368_s_at)−−− (241924_at)TDRD3 (208089_s_at)RBM15 (1555762_s_at)SIN3A (238005_s_at)−−− (239574_at)CCDC88A (238759_at)GTF3C3 (222604_at)ZNF782 (235290_at)TCHP (223455_at)RUNX1T1 (205528_s_at)TP53BP2 (203120_at)MED6 (210104_at)−−− (236506_at)RABEP1 (231002_s_at)QSOX2 (235239_at)FAM76B (1553750_a_at)GLMN (207153_s_at)ZNF823 (229732_at)−−− (1564765_at)−−− (235985_at)LARS (222427_s_at)C4orf18 (219872_at)KSR1 (213770_at)−−− (228562_at)MN1 (205330_at)NFXL1 (227220_at)GRK6 (202848_s_at)IL18R1 (206618_at)−−− (240141_at)FAM83B (1563900_at)−−− (236591_at)−−− (226347_at)CASP1 (209970_x_at)PGAP1 (239725_at)LOC399959 (241975_at)−−− (215545_at)−−− (236480_at)−−− (238651_at)C6orf26 /// MSH5 (212913_at)−−− (242092_at)C9orf100 (230522_s_at)VTI1A (235923_at)TRIM13 (1569142_at)ELF2 (203822_s_at)C13orf33 (227058_at)RGS20 (210138_at)IPO11 (1557770_at)KLHL5 (233866_at)CBS (212816_s_at)CBS (1553972_a_at)VLDLR (209822_s_at)CEBPD (213006_at)DNTTIP1 (234942_s_at)−−− (231035_s_at)−−− (239571_at)ATP5S (213995_at)LOC100132891 (228438_at)PRKRA /// PRKRAP1 (237107_at)GPSM2 (221922_at)CA5BP (238435_at)BMP2K (59644_at)FAM164A (241808_at)PWWP2A (226720_at)MYEF2 (229464_at)NANP (228073_at)−−− (217570_x_at)ZNF33A (232873_at)−−− (243561_at)SRR (219205_at)SNX16 (229618_at)DBR1 (234295_at)FMNL2 (226184_at)KLF12 (239019_at)LCORL (240592_at)CPOX (204172_at)−−− (235748_s_at)FAM186A (216595_at)−−− (222294_s_at)PATL1 (244342_at)SCLT1 (236487_at)MGA (230848_s_at)−−− (232681_at)BNC2 (220272_at)CHD1 (235791_x_at)ADSL (202144_s_at)−−− (233713_at)CCDC15 (220466_at)DBF4B (238508_at)−−− (220969_s_at)TAF5 (1553528_a_at)PCDH7 (205534_at)WWC3 (219520_s_at)−−− (240671_at)GUCY1B3 (211555_s_at)G2E3 (223258_s_at)NEK3 (211089_s_at)ZBTB2 (226284_at)LRRC15 (213909_at)PARP2 (215773_x_at)NARS2 (219217_at)CCDC15 (241360_at)EVI2A (204774_at)NUP88 (202900_s_at)ZBTB24 (1554036_at)RCCD1 (226488_at)−−− (235919_at)−−− (239790_s_at)SGOL1 (231938_at)NARG1 (226998_at)KIAA1731 (229878_at)C3orf41 (228721_at)GPD2 (225447_at)CELSR2 (204029_at)NRF1 (204651_at)PECR (221142_s_at)C9orf40 (218904_s_at)NUDT21 (213461_at)NOL8 (218244_at)ZNF829 (238952_x_at)PARP11 (229138_at)SP4 (236265_at)TUBD1 (231853_at)CCDC111 (227157_at)SEPT13 (230355_at)TLE3 (212770_at)MPHOSPH9 (221965_at)CENPL (1554271_a_at)ZRANB3 (239538_at)RCL1 (218544_s_at)−−− (240149_at)NPR3 (219789_at)C14orf109 (213246_at)C15orf41 (224486_s_at)C13orf16 (236853_at)PCM1 (202174_s_at)HNRNPA0 (201054_at)−−− (236369_at)−−− (235203_at)WEE1 (215711_s_at)ECT2 (234992_x_at)NCAPD3 (212789_at)RBM14 (204178_s_at)KIF2C (211519_s_at)−−− (235111_at)RBM12 (212170_at)SNX5 (222417_s_at)CCNE2 (211814_s_at)INTS7 (222250_s_at)DPH5 (223671_x_at)MSH6 (211450_s_at)BRD4 (226054_at)CTBP2 (210835_s_at)STK33 (228035_at)NIP30 (224248_x_at)HNRNPL (202072_at)SUV39H2 (1554572_a_at)SLFN11 (226743_at)ADCY3 (209320_at)DCK (203302_at)LRRC49 (219338_s_at)CENPJ (220885_s_at)NUSAP1 (219978_s_at)−−− (1557029_at)EZH2 (203358_s_at)ESCO2 (235588_at)FOXM1 (202580_x_at)ATAD2 (218782_s_at)SEPHS1 (208940_at)C3orf26 (224523_s_at)KCNJ8 (205303_at)BUB3 (201457_x_at)ZNF711 (228988_at)C10orf119 (222464_s_at)KPNA2 (211762_s_at)MLF1IP (229304_s_at)−−− (1558947_at)CEP78 (1557985_s_at)FOSL2 (218881_s_at)RPRD1A (228566_at)MED21 (209362_at)GPT2 (224839_s_at)RBM10 (208984_x_at)PI4K2B (222631_at)HDAC1 (201209_at)−−− (241726_at)EIF4B (211937_at)PIK3CD (203879_at)SMAD2 (226563_at)ZNF830 (226323_at)PGK1 (200737_at)HIC1 (230218_at)C1orf174 (238010_at)SNTB1 (214708_at)TET3 (235542_at)FBLN1 (207835_at)ZC4H2 (225784_s_at)−−− (231493_at)TRIM5 (223830_s_at)LOC149773 (1559433_at)MTUS1 (212093_s_at)−−− (1569338_at)−−− (233768_at)ELF2 (210361_s_at)KCTD15 (222668_at)COLEC12 (221019_s_at)TMTC4 (1554101_a_at)LOC541471 (1562876_s_at)RABL2A /// RABL2B (219151_s_at)TMPO (237863_at)EXOSC6 (1558044_s_at)IRF2 (203275_at)−−− (235242_at)−−− (237334_at)−−− (233174_at)−−− (243046_at)ITGB8 (205816_at)KIAA0922 (209760_at)SETDB1 (203155_at)LOC728264 (227183_at)MRPL13 (218049_s_at)ZFP161 (209724_s_at)GABPB1 (206173_x_at)GPM6B (209168_at)MKL2 (218259_at)THYN1 (218491_s_at)ZNF362 (226820_at)C11orf61 (221208_s_at)−−− (236372_at)GTF3C4 (219198_at)BAZ1A (217985_s_at)−−− (233623_at)LSM14A (222099_s_at)TBP (203135_at)CTBP2 (201220_x_at)NOL11 (221970_s_at)ETS1 (214447_at)ATL2 (235848_x_at)LOC100132884 (228899_at)LOC647946 (240365_at)CNPY3 (1552977_a_at)−−− (238637_at)−−− (230998_at)−−− (224417_at)POP1 (213449_at)SDR42E1 (229522_at)SNRPA1 (215722_s_at)−−− (243948_at)EIF3A (200597_at)POGZ (212153_at)GTF2IRD1 (218412_s_at)HNRNPL (35201_at)APAF1 (211554_s_at)ARNTL (210971_s_at)TM6SF1 (219892_at)NAB2 (212803_at)−−− (243847_at)RERE (200938_s_at)−−− (232615_at)SRCAP (215053_at)RCN3 (219102_at)VEGFA (212171_x_at)PPIA (217602_at)MRPL23 (213897_s_at)−−− (1558011_at)LYPD6 (239028_at)LOC100132815 (1560446_at)GJA3 (239572_at)ZNF827 (243617_at)XIST (243712_at)SCD (211708_s_at)AASS (214829_at)−−− (238968_at)−−− (236679_x_at)LIMD2 (218600_at)AGPAT4 (219693_at)FAM85A (238716_at)−−− (220467_at)RP5−1022P6.2 (224826_at)PALLD (1557535_at)PURB (228467_at)CXorf24 (239034_at)RCOR2 (236030_at)−−− (235887_at)RECQL4 (1553015_a_at)TCF4 (222146_s_at)SMAD4 (235725_at)SERPINH1 (207714_s_at)RASL12 (219167_at)NNMT (231559_at)KSR1 (235252_at)−−− (242014_at)SRGAP2P1 (229067_at)SCD (200831_s_at)KIAA0146 (228325_at)GHDC (227159_at)−−− (237798_at)PCDHGB7 (1552662_a_at)COL6A1 (212091_s_at)−−− (221105_at)SPTLC3 (227752_at)MEGF8 (214778_at)ARID2 (1553349_at)−−− (244025_at)COL6A1 (212940_at)COL6A1 (212939_at)−−− (1557238_s_at)NNMT (202238_s_at)FXYD6 (217897_at)−−− (226348_at)ISG20 (33304_at)FAM13A (1569024_at)MGC24103 (232568_at)−−− (1559410_at)WFDC3 (232602_at)−−− (239788_at)CDC2L6 (212897_at)GYPC (202947_s_at)−−− (241060_x_at)TGFB1I1 (209651_at)TRIOBP (210276_s_at)RARRES1 (206392_s_at)PDE7A (1552343_s_at)SNRPN (1559545_at)LOC284757 (1562051_at)GGA2 (214190_x_at)LOC286109 (243304_at)COQ7 (209746_s_at)PPARD (242218_at)FAM100B (224783_at)COL6A1 (212937_s_at)CC2D2A (234933_at)FAT3 (236029_at)AHCTF1 (1560224_at)−−− (244016_at)NRP2 (228102_at)−−− (239783_at)TMEM92 (235245_at)ANKRD18A /// ANKRD18B /// ANKRD19 /// LOC728897 /// RP11−195B21.3 /// RP11−38M15.10 (233592_at)SEMA3F (35666_at)ALKBH2 (225625_at)−−− (235917_at)PET112L (204300_at)C7orf49 (220949_s_at)FAM161A (1564467_at)SLC7A1 (212292_at)SYNCRIP (236146_at)AAAS (218075_at)DNAJC17 (219861_at)−−− (244329_at)CLN6 (1567081_x_at)tcag7.1196 (228294_s_at)−−− (233867_at)IL11 (206926_s_at)TRAF1 (205599_at)HOXC6 (206858_s_at)ERCC8 (1554882_at)IMPA2 (203126_at)CSPG4 (214297_at)CCDC150 (243565_at)UTP18 (222038_s_at)SMC1A (239688_at)LOC100134401 /// LOC100272216 (213605_s_at)BCL2A1 (205681_at)FLJ35409 (1559506_x_at)SLC16A7 (207057_at)C15orf44 (221265_s_at)NARF (219862_s_at)PDIA4 (208658_at)PSMG3 (223363_at)ZNF70 (1554578_at)PACSIN3 (218744_s_at)RPS9 (214317_x_at)USP48 (220078_at)FKBP4 (200895_s_at)GINS4 (1554356_at)−−− (233194_at)ZNRD1 (223639_s_at)KIAA0114 (224870_at)−−− (228959_at)RNASEH2B (229210_at)TRPC3 (206425_s_at)DOK5 (1554863_s_at)PDSS1 (220865_s_at)NPAT (211584_s_at)PLAGL2 (202924_s_at)PIH1D1 (217872_at)HIST1H2BO (214540_at)SUV39H1 (218619_s_at)ARSI (230275_at)GGA2 (213772_s_at)SOCS3 (227697_at)ECHDC3 (219298_at)FAM132B (229622_at)BICD1 (214806_at)PHLPP (212719_at)VEZF1 (202173_s_at)LRRFIP1 (223492_s_at)ENPEP (204844_at)NPAS2 (39548_at)SCD (200832_s_at)NID2 (204114_at)HS3ST3B1 (227361_at)ATF1 (222103_at)SHROOM3 (225548_at)DDIT4 (202887_s_at)VEGFA (210512_s_at)IL6 (205207_at)RASSF2 (203185_at)MTUS1 (212095_s_at)AKAP12 (227530_at)GAS7 (211067_s_at)SEMA5A (229427_at)−−− (237031_at)MTUS1 (212096_s_at)FAM65B (206707_x_at)HOXA7 (206847_s_at)C1orf77 (202560_s_at)HS3ST3A1 (219985_at)AKAP12 (210517_s_at)ATP2B1 (215716_s_at)PTGS2 (204748_at)SULF1 (212344_at)−−− (222168_at)DDX43 (220004_at)MATN3 (206091_at)ARL6IP6 (225707_at)LRRC40 (218577_at)MTHFD1L (225520_at)PGK1 (227068_at)TFPI2 (209277_at)MESDC2 (224672_x_at)CDH11 (239286_at)SEPT6 (212413_at)LRCH3 (228119_at)SLC7A2 (225516_at)CREB5 (205931_s_at)GALNT7 (222587_s_at)CCDC8 (223496_s_at)GAS7 (202191_s_at)TCEA3 (226388_at)FUT11 (238551_at)HDX (1553646_at)ANG (205141_at)−−− (228156_at)PTGIS (211892_s_at)WFDC10B (1552999_a_at)hCG_1771830 (1559274_at)VSIG2 (229369_at)NAB1 (208047_s_at)RND2 (213467_at)PBX1 (205253_at)PKMYT1 (204267_x_at)CYGB (226632_at)ZNF518A (244132_x_at)CAPG (201850_at)−−− (233989_at)C7orf68 (1554452_a_at)VSNL1 (203798_s_at)PTPRN (204945_at)TCERG1 (229706_at)MFI2 (223723_at)MKL2 (1558777_at)MDFIC (217599_s_at)SRFBP1 (241734_at)NDE1 (218414_s_at)−−− (226480_at)VPRBP (226476_s_at)ATF1 (1565269_s_at)TRIO (209010_s_at)SEPT6 (1555526_a_at)C14orf167 (224153_s_at)SMAD4 (1565702_at)LIMS3−LOC440895 /// LOC440895 (229095_s_at)−−− (1563902_at)LOC441528 (1558046_x_at)DCLRE1C (219678_x_at)−−− (1559222_at)ZNF695 (208273_at)−−− (1562076_at)VMA21 (242474_s_at)−−− (238565_at)BCL9 (204129_at)RP5−1022P6.6 (229992_at)GLT25D1 (218473_s_at)LOC729397 (225854_x_at)TRIM28 (200990_at)−−− (213580_at)−−− (232273_at)DSCC1 (216646_at)BGN (201262_s_at)CTDSP1 (217844_at)HS3ST3B1 (1561908_a_at)COL6A1 (214200_s_at)MED16 (43544_at)RP5−1022P6.2 (224835_at)AKT3 (222880_at)NOL12 /// TRIOBP (219324_at)NDRG2 (206453_s_at)CDKN2AIPNL (235006_at)ZNF747 (228856_at)ARL5B (242727_at)TOP3A (214300_s_at)RBBP4 (244872_at)TRERF1 (238520_at)AKT2 (203809_s_at)RICS (242196_at)C7orf47 (226434_at)MIF (217871_s_at)RCN3 (61734_at)−−− (1560889_a_at)−−− (242754_at)RPL8 (200936_at)TAGLN2 (210978_s_at)PTBP1 (226491_x_at)C2orf37 (220172_at)ZNF747 (206180_x_at)MYBL2 (201710_at)BAX (211833_s_at)−−− (1557192_at)DPY19L1 (1560916_a_at)IRF6 (202597_at)HOXC9 (231936_at)−−− (222284_at)−−− (232468_at)LSM7 (204559_s_at)ARHGDIA (201168_x_at)−−− (231470_at)ARL6IP4 (218216_x_at)EIF5A (201123_s_at)IGF2BP1 (223689_at)G3BP1 (201514_s_at)UBTF (214881_s_at)SMARCA4 (208793_x_at)UBTF (1558215_s_at)ZNF114 (1552946_at)ENSA (228851_s_at)NFYC (211797_s_at)UNC84A (230210_at)COL18A1 (209081_s_at)ABCA1 (216066_at)ST3GAL1 (208322_s_at)RARRES2 (209496_at)GLT25D1 (222644_s_at)DNAJB5 (207453_s_at)TMCO6 (221096_s_at)RRP7A (33307_at)−−− (238748_at)TRIOBP (243690_at)−−− (1557433_at)PLEKHG4B (230441_at)LAMB3 (209270_at)TSGA14 (225484_at)SP3 (227537_s_at)LITAF (200706_s_at)FXYD5 (218084_x_at)LOC284889 (1556316_s_at)EIF4EBP1 (221539_at)YRDC (222703_s_at)MLLT10 (216509_x_at)ADARB1 (234539_at)FXYD5 (224252_s_at)TET3 (214754_at)HIST1H2AB (208569_at)HIST1H4B (208180_s_at)NT5C (219214_s_at)MAGOH (210093_s_at)LOC285943 (242528_at)TCOF1 (202384_s_at)BRD4 (202102_s_at)PIP4K2A (205570_at)THRAP3 (217847_s_at)SIPA1L2 (1559469_s_at)MED28 (222636_at)PHC1 /// PHC1B (218338_at)DNAJB5 (212817_at)SLC8A1 (1561615_s_at)DIAPH1 (213514_s_at)THRAP3 (222439_s_at)FMR1 (203689_s_at)FNDC3A (238961_s_at)SP1 (1553685_s_at)ABI3 (223615_at)CAMK4 (241871_at)WHSC1 (209052_s_at)HIST1H3A (208575_at)ATXN3 (205416_s_at)−−− (241940_at)VASH2 (219740_at)−−− (233187_s_at)BCAT1 (214390_s_at)−−− (231343_at)LOC169834 (230876_at)TCF4 (212386_at)SYNC (221276_s_at)TNFAIP8 (208296_x_at)RAB8B (219210_s_at)THUMPD1 (213025_at)KBTBD2 (223585_x_at)CC2D2A (1559409_a_at)−−− (233275_at)FNDC1 (226930_at)SNF8 (218391_at)GMEB1 (220938_s_at)ZYX (215706_x_at)ZNF518A (215644_at)ZNF587 (1558251_a_at)−−− (1557610_at)−−− (243745_at)SFRP1 (228413_s_at)ZNF770 (220608_s_at)AR (211621_at)PEG3 (230068_s_at)CGA (204637_at)BHMT2 (219902_at)FBXO16 /// ZNF395 (232693_s_at)−−− (244177_at)PTBP1 (212016_s_at)TTLL4 (203703_s_at)CTBP1 (203392_s_at)TBL1X (201867_s_at)MGC12916 (224508_at)CTDSP2 (208735_s_at)MEGF8 (227327_at)PDE7B (220343_at)VEGFA (210513_s_at)SEMA5A (205405_at)SPSB1 (226075_at)ZC3H12C (1559763_at)FOSL2 (218880_at)CALML4 (1566150_at)−−− (244764_at)GAS7 (207704_s_at)HIST3H2A (231681_x_at)PTBP1 (211271_x_at)NT5DC2 (218051_s_at)HCFC1 (202474_s_at)IER2 (202081_at)ANKLE1 (1553138_a_at)RPL3 (211666_x_at)HNRNPD (227744_s_at)SLC7A1 (215979_s_at)CLN6 (218161_s_at)NUP43 (238474_at)ILF3 (208930_s_at)FAM76B (226753_at)BACE2 (217867_x_at)PPAT (209433_s_at)MDK (209035_at)HIST1H2BB (208547_at)AKT3 (224229_s_at)−−− (238836_at)KIAA1324L (235301_at)HELB (1552787_at)KREMEN1 (224534_at)−−− (1558919_a_at)FLJ41757 (1557372_at)CBY3 (241712_at)GLYATL2 (1554712_a_at)HOXC4 (206194_at)−−− (234110_at)KIAA1841 (243539_at)ACN9 (218981_at)UBA2 (201177_s_at)−−− (226832_at)ZNF273 (215239_x_at)APPL1 (218158_s_at)−−− (230958_s_at)UNK (228357_at)PHF3 (217954_s_at)−−− (235506_at)−−− (1556216_s_at)ZNF626 (235687_at)EMB (226789_at)WDR89 (235025_at)ZNF519 (1564190_x_at)−−− (237600_at)POGK (239392_s_at)−−− (221202_at)FARSB (232063_x_at)−−− (232254_at)PGAP1 (241801_at)ZNF738 (229700_at)PCMTD1 (238114_at)NACAD (213630_at)−−− (240738_at)DDX60L (1559585_at)−−− (230696_at)−−− (1555970_at)−−− (1569487_at)−−− (242613_at)CEP250 (210894_s_at)GRIK2 (1563754_at)−−− (228612_at)UBE2L3 (200683_s_at)HPS3 (238539_at)SLC25A40 (205716_at)SEPT13 (1569973_at)ZCRB1 (227416_s_at)ZNF286A (220250_at)HIST1H2AI (214542_x_at)PIM3 (224739_at)ATPAF1 (224728_at)MDC1 (203061_s_at)DNAJC22 (220441_at)FAM161A (1557385_at)−−− (234522_at)−−− (1558473_at)DIAPH3 (220997_s_at)C21orf66 (221158_at)−−− (240538_at)AKAP10 (236007_at)RLF (204243_at)PIGA (205281_s_at)MRTO4 (235783_at)−−− (232889_at)DPPA4 (232985_s_at)MITD1 (226329_s_at)−−− (1558801_at)WTAP (203137_at)−−− (1557624_at)−−− (239363_at)SYNE2 (242774_at)PTPRB (230250_at)EIF3F (200023_s_at)CHM (1569183_a_at)ILF3 (217805_at)RPGR (207624_s_at)JUB (225807_at)CTDSPL2 (223270_at)RNF138 (239143_x_at)AMMECR1 (204976_s_at)WDHD1 (204728_s_at)CKLF (223451_s_at)SFRS7 (201129_at)−−− (1569596_at)PDE3B (214582_at)LOC284926 (1556064_at)NRP1 (1561365_at)ING3 (242293_at)RAP2C (218669_at)ZADH2 (227049_at)BUB3 (201458_s_at)CENPM (218741_at)−−− (230752_at)API5 (233078_at)PRPF4B (202126_at)PRR3 (204795_at)MID1 (203636_at)ZNF273 (243661_at)SIAH1 (202980_s_at)LZTS1 (47550_at)RBPMS2 (228802_at)C13orf37 (225578_at)LYPD6 (227764_at)TMEM126A (223334_at)LRRCC1 (231872_at)PRMT6 (223275_at)C18orf54 (1553651_at)CPSF6 (226934_at)RALGPS2 (227224_at)AGTR1 (208016_s_at)CHML (226350_at)LOC100127983 (228107_at)LONRF1 (226038_at)−−− (233445_at)TMEM194A (212621_at)MBP (210136_at)TUSC1 (227388_at)HNRPDL (209068_at)GRLF1 (229394_s_at)ILF3 (211375_s_at)TMEM30B (213285_at)PTBP1 (211270_x_at)ELAVL1 (201726_at)SLC2A4RG (227362_at)TSGA14 (225485_at)SPATA6 (220298_s_at)TNFAIP3 (202643_s_at)AFG3L1 (1552287_s_at)HTRA3 (228580_at)TCF3 (209153_s_at)METTL10 (226634_at)SHPK (219713_at)HAUS5 (36888_at)PHB2 (201600_at)ZFPM2 (219778_at)SNRPB (208821_at)CPSF6 (202470_s_at)UNG (202330_s_at)MPHOSPH9 (215731_s_at)TIMM10 (218408_at)DPF3 (219746_at)FAM178A (203482_at)ZNF215 (220214_at)TRIM34 /// TRIM6−TRIM34 (224175_s_at)UBE2I (213536_s_at)HNRNPM (200072_s_at)PCM1 (214937_x_at)KIAA1199 (1554685_a_at)SNTB1 (208608_s_at)KIAA1199 (212942_s_at)EDNRB (204271_s_at)MAP3K8 (205027_s_at)TGFBR1 (206943_at)XIST (227671_at)TCF7L2 (216035_x_at)CARHSP1 (218384_at)TP53 (201746_at)LOC644714 (233541_at)−−− (1560797_s_at)TBL1XR1 (221428_s_at)NCOA6 (1568874_at)ZFYVE16 (240859_at)TRO (210882_s_at)−−− (237814_at)SETBP1 (205933_at)AKT3 (219393_s_at)MBTD1 (243552_at)LFNG (228762_at)FAM108C1 (225436_at)PTTG3 (208511_at)WNT2 (205648_at)CCDC66 (1560177_at)−−− (244793_at)−−− (227963_at)−−− (215635_at)−−− (240000_at)RHPN2 (227196_at)−−− (241864_x_at)FGD4 (227948_at)PTGIS (210702_s_at)CDKN1C (213183_s_at)EDNRB (206701_x_at)VAT1L (226415_at)PSAT1 (223062_s_at)CDR2 (209501_at)PTGIS (208131_s_at)SMOC1 (222784_at)MAGOH2 (217692_at)ABCG1 (204567_s_at)INHBE (210587_at)HSPA2 (211538_s_at)PTGES (210367_s_at)TRPC5 (220552_at)−−− (235109_at)C1orf74 (229933_at)ICMT (201610_at)−−− (217578_at)ING3 (231863_at)B3GALT2 (210121_at)FAM110A (226584_s_at)CEP152 (215882_at)−−− (244335_at)C21orf116 (223951_at)TCF7L2 (216037_x_at)STAT5B (212549_at)FAM49A (209683_at)ASS1 (207076_s_at)MDFIC (1559942_at)−−− (37590_g_at)−−− (240442_at)COL7A1 (204136_at)TPD52L1 (203786_s_at)PDE4D (228962_at)UCN2 (232674_at)HIST1H2BN (207226_at)FLJ20674 (220137_at)ISG20 (204698_at)−−− (237353_at)MRPS15 (223292_s_at)LOC286434 (1556102_x_at)HMGA2 (1567224_at)BANF1 (210125_s_at)−−− (228843_at)RPS16 (201258_at)−−− (241316_at)POLD1 (203422_at)−−− (235949_at)C1orf190 (235214_at)GPM6B (209169_at)GTF2IRD2 (228765_at)−−− (227793_at)−−− (235429_at)SNRNP200 (232931_at)ZNF544 (218735_s_at)−−− (1567183_s_at)TBC1D4 (203387_s_at)CCNY (224651_at)−−− (242409_at)CDC2L6 (235226_at)ADAP2 (219358_s_at)POLA2 (204441_s_at)MED30 (227787_s_at)−−− (239678_at)PASK (216945_x_at)PASK (213534_s_at)−−− (235785_at)CDKAL1 (220039_s_at)PHF20L1 (231967_at)ZNF202 (204329_s_at)−−− (1560792_at)RP11−138L21.1 (220436_at)TCF7L2 (216511_s_at)−−− (238976_at)STAT3 (243213_at)CTAG1A /// CTAG1B (211674_x_at)KIF21A (226003_at)NRGN (204081_at)AFAP1L2 (226829_at)TGFBR3 (226625_at)SYNE2 (202761_s_at)FNIP1 (1559060_a_at)CPM (217557_s_at)MGC12916 (224507_s_at)SSPN (204964_s_at)KIAA1598 (221802_s_at)RAB33A (206039_at)VPS13A (214785_at)DPH5 (224196_x_at)FAM36A (224824_at)−−− (239133_at)AS3MT (223652_at)HNRNPUL1 (209675_s_at)HNRNPC (227110_at)−−− (236346_at)−−− (235786_at)ADAMTS6 (1570351_at)WDR67 (1556429_a_at)HMBS (203040_s_at)−−− (227579_at)C1orf21 (223126_s_at)−−− (229026_at)CCT8 (210436_at)SERBP1 (228129_at)GLUL (200648_s_at)STRBP (233252_s_at)MTF2 (203346_s_at)SEPT9 (208657_s_at)AFF3 /// MLL (1565034_s_at)HOXA9 (214651_s_at)SFRS3 (237485_at)SLC4A5 (234976_x_at)NAV2 (222599_s_at)−−− (239744_at)−−− (1559006_at)MED13L (212208_at)NIN (234299_s_at)DDX18 (205763_s_at)PHKA2 (209439_s_at)ZNF395 (222536_s_at)SMAD2 (235598_at)MKL2 (1570202_a_at)BCLAF1 (239897_at)CBX3 (1555920_at)DHX37 (223365_at)PDS5B (207956_x_at)RAD1 (235253_at)B3GALT2 (217452_s_at)−−− (209535_s_at)−−− (238129_s_at)TRBC1 (210915_x_at)−−− (242872_at)DSC3 (206032_at)FAM161A (239090_at)KIT (205051_s_at)ZMAT4 (219877_at)ROBO3 (219550_at)CTDSP2 (203445_s_at)TMEM158 (213338_at)CDCP1 (218451_at)VEGFA (211527_x_at)MME (203435_s_at)ENO2 (201313_at)NNMT (202237_at)−−− (235733_at)−−− (213657_s_at)TPI1 (213011_s_at)SERPINF1 (202283_at)AKAP12 (227529_s_at)SEMA4B (234725_s_at)PDLIM3 (209621_s_at)IL11 (206924_at)GLIPR2 (225602_at)CDCP1 (234932_s_at)MME (203434_s_at)−−− (222288_at)ZNF469 (230440_at)JARID2 (203297_s_at)PTGFRN (224950_at)LRIG1 (236173_s_at)SHMT2 (214437_s_at)−−− (243156_at)TACC2 (211382_s_at)ARL3 (202641_at)FOXP1 (224837_at)BGN (201261_x_at)BGN (213905_x_at)MAB21L2 (210303_at)−−− (230135_at)H1F0 (208886_at)CENPV (226610_at)SMARCC1 (201075_s_at)N4BP2 (231996_at)ZNF395 (223216_x_at)ZNF827 (243618_s_at)TRO (211700_s_at)PXMP2 (219076_s_at)EXO1 (204603_at)MTMR4 (214268_s_at)KIF15 (219306_at)NHSL1 (234321_x_at)PRR16 (1554867_a_at)C12orf48 (220060_s_at)CSRP2 (211126_s_at)CENPH (231772_x_at)MTBP (233211_at)PDLIM3 (238592_at)UBE2N (201524_x_at)CKLF (221058_s_at)HIST1H2BF (208490_x_at)AUTS2 (212599_at)MAPK13 (210058_at)MLX (217910_x_at)RBMX (213762_x_at)GCNT1 (205505_at)AEBP1 (201792_at)NPTX1 (204684_at)CRLS1 (223978_s_at)SERPINB9 (209723_at)PRRX1 (205991_s_at)NUPL1 (225047_at)MARCKS (225897_at)C18orf54 (241733_at)SMC2 (213253_at)KLF12 (227261_at)RAB27A (209514_s_at)HIST1H2BD (222067_x_at)HUNK (1555935_s_at)KIAA1524 (231855_at)GAS2L3 (238756_at)MCM2 (202107_s_at)CDCA3 (223307_at)KLHL13 (227875_at)SGOL2 (230165_at)RRM1 (201476_s_at)HMGB3L1 (216548_x_at)HJURP (218726_at)FBXO5 (234863_x_at)CPS1 (204920_at)WDR76 (205519_at)BUB1 (216275_at)MKI67 (212023_s_at)−−− (242890_at)CEP70 (219036_at)MCM3 (201555_at)POLE2 (205909_at)CHEK1 (238075_at)GINS3 (45633_at)FAM83D (225687_at)CCNB2 (202705_at)C4orf46 (238015_at)UBR7 (218108_at)KIF2C (209408_at)PBK (219148_at)NRP1 (212298_at)CCNF (204826_at)SLC43A3 (213113_s_at)NAV2 (218330_s_at)ATAD2 (235266_at)POLQ (219510_at)−−− (226192_at)DEPDC1 (220295_x_at)C14orf145 (233859_at)EVI1 (226420_at)MCM4 (222037_at)HIST1H3I (214509_at)HIST1H1A (208484_at)HIST1H2BM (208515_at)HIST1H4B (214516_at)MCM7 (210983_s_at)NCAPG2 (219588_s_at)CENPF (209172_s_at)APOBEC3B (206632_s_at)NETO2 (222774_s_at)RRM2 (201890_at)TRIP13 (204033_at)UBE2C (202954_at)DHFR (202533_s_at)DUT (209932_s_at)ASPM (232238_at)IQGAP3 (1569062_s_at)ENPP1 (205065_at)ZNF22 (218006_s_at)TMPO (209753_s_at)TMPO (209754_s_at)LBR (201795_at)ANP32E (208103_s_at)H2AFZ (213911_s_at)AURKA (204092_s_at)ATP2B1 (209281_s_at)BNC2 (230722_at)CRABP2 (202575_at)HHIP (237466_s_at)GLIPR2 (225604_s_at)PTMAP7 (208549_x_at)MARCKS (201670_s_at)NUCKS1 (226880_at)NUCKS1 (217802_s_at)DOK5 (214844_s_at)HIST1H2BE (208527_x_at)−−− (216554_s_at)C10orf140 (1559266_s_at)AURKB (209464_at)RAD1 (210216_x_at)HIST1H4J /// HIST1H4K /// HIST4H4 (208580_x_at)BRD4 (226052_at)GPR161 (232350_x_at)C14orf106 (226630_at)SIX1 (205817_at)GFPT2 (205100_at)CEP135 (206003_at)TES (202719_s_at)NEDD1 (1552417_a_at)CASP2 (34449_at)H3F3A /// H3F3B /// LOC440926 (211940_x_at)GNG2 (224965_at)C16orf75 (226456_at)MCM6 (238977_at)CENPJ (223513_at)SULF1 (212354_at)SOCS1 (210001_s_at)BACE2 (222446_s_at)−−− (222344_at)CDCA7L (225081_s_at)DNMT3A (218457_s_at)AMOTL1 (225459_at)PRSS12 (205515_at)SET (213047_x_at)SET (200631_s_at)SALL2 (213283_s_at)CHD1L (207645_s_at)ANKRD28 (226025_at)NUCKS1 (224581_s_at)CTDSPL2 (1555106_a_at)FUSIP1 (204299_at)HPRT1 (202854_at)FRMD4A (225163_at)NFIL3 (203574_at)ZFP36L2 (201368_at)ZBTB38 (236557_at)EDNRA (204463_s_at)NEDD1 (1560116_a_at)CCDC123 (1554513_s_at)MESDC2 (224675_at)−−− (235657_at)TRDMT1 (206308_at)ZNF395 (218149_s_at)TRIM6 (223599_at)PDE7B (230109_at)NPAT (209798_at)ADARB1 (203865_s_at)DSG2 (217901_at)POSTN (1555778_a_at)PSIP1 (209337_at)CYP1B1 (202436_s_at)GPC6 (227059_at)CYP1B1 (202437_s_at)CA12 (203963_at)TTK (204822_at)NETO2 (218888_s_at)RPL39L (210115_at)−−− (229490_s_at)NUF2 (223381_at)KIF18B (222039_at)TMSB15A (205347_s_at)FBXO5 (218875_s_at)C5orf13 (201310_s_at)−−− (235846_at)BNC1 (1552487_a_at)LOC654433 (228425_at)SHROOM2 (204967_at)C1orf21 (223125_s_at)FEN1 (204767_s_at)HOXA3 (235521_at)DEPDC1 (235545_at)SHCBP1 (219493_at)RMI1 (218979_at)FRMD4A (225168_at)EDNRA (216235_s_at)ALMS1 (214221_at)C12orf32 (225836_s_at)CYP1B1 (202435_s_at)NRIP1 (202599_s_at)ANLN (222608_s_at)CLDN11 (228335_at)TUBB2C (208977_x_at)PDE7A (223358_s_at)CBX5 (231862_at)PTMA (200773_x_at)CCL2 (216598_s_at)−−− (221625_at)PTN (209465_x_at)GCNT1 (239761_at)KDELC2 (225128_at)−−− (239680_at)SYNCRIP (217832_at)−−− (1560296_at)CDK2 (204252_at)LOC643287 (216384_x_at)S100A16 (227998_at)MKI67 (212020_s_at)PTN (211737_x_at)LSAMP (214460_at)SYNE2 (1558392_at)MEX3A (227512_at)FAM162B (228875_at)PLK1 (202240_at)C14orf106 (206500_s_at)MTBP (1552518_s_at)PCOLCE (202465_at)QSER1 (244563_at)AMPH (205257_s_at)−−− (227533_at)FAM129A (217966_s_at)ENO1 (201231_s_at)FGFR1OP (205588_s_at)DDX39 (201584_s_at)C21orf45 (229671_s_at)EXOSC3 (227916_x_at)NRM (225592_at)C21orf45 (219004_s_at)BARD1 (205345_at)DIAPH3 (232596_at)TROAP (1568596_a_at)H2AFX (213344_s_at)CDC25C (217010_s_at)HAUS8 (226308_at)−−− (1557256_a_at)FRMD4A (225167_at)MCM7 (208795_s_at)CDCA4 (218399_s_at)NCAPD2 (201774_s_at)MKI67 (212021_s_at)ANP32A (201051_at)HNRNPAB (201277_s_at)FKBP5 (204560_at)TRIM59 (235476_at)GPSM2 (205240_at)FANCG (203564_at)HNRNPH1 (213470_s_at)NUCKS1 (229353_s_at)CDCA3 (221436_s_at)SMC3 (209258_s_at)RALGPS2 (232112_at)MBP (228938_at)MYBL1 (213906_at)NRK (232771_at)SKP2 (203625_x_at)RAD54B (220549_at)−−− (236716_at)BDH1 (211715_s_at)CACYBP (211761_s_at)TRIM55 (236175_at)FANCD2 (223545_at)PFAS (213302_at)MCM10 (222962_s_at)KIF23 (204709_s_at)ATAD5 (220223_at)QSER1 (229982_at)TMEM97 (212282_at)TFAM (203176_s_at)HNRNPH3 (208990_s_at)SLC16A1 (202236_s_at)−−− (224216_at)SUPT16H (233827_s_at)HDGFRP3 (209525_at)PLK4 (211088_s_at)−−− (238431_at)TOPBP1 (202633_at)TRIM59 (227801_at)HMMR (207165_at)ANLN (1552619_a_at)NEDD1 (234984_at)ENPP1 (229088_at)MCM6 (201930_at)DEPDC1 (232278_s_at)LASS6 (242019_at)BIRC5 (202094_at)CDC2 (231534_at)−−− (1556834_at)HELLS (227350_at)ALDH1A3 (203180_at)NEIL3 (219502_at)IQGAP3 (229538_s_at)CCNB1 (228729_at)CENPN (222118_at)ASPM (219918_s_at)NHSL1 (226490_at)SAP30 (213963_s_at)SPC25 (209891_at)SNRPD1 (202690_s_at)UHRF1 (225655_at)EGR1 (201694_s_at)B3GNT5 (225612_s_at)PFKP (201037_at)GABRB1 (207010_at)SMC2 (204240_s_at)C18orf24 (217640_x_at)−−− (228273_at)FGFR1OP (1568678_s_at)CBX5 (234990_at)STMN3 (222557_at)CHEK1 (205394_at)SOX11 (204915_s_at)DTYMK (1553984_s_at)PSRC1 (201896_s_at)ZYG11A (231517_at)C21orf45 (228597_at)DTL (222680_s_at)C14orf145 (232635_at)CIT (212801_at)RAD51 (205024_s_at)RBMX (225310_at)RBBP8 (203344_s_at)SFRS2 (214882_s_at)NCAPG (218663_at)KIF20A (218755_at)CENPA (204962_s_at)PTN (209466_x_at)CDKN3 (1555758_a_at)MLF1IP (229305_at)SHMT1 (224954_at)SOX11 (204913_s_at)ECT2 (237241_at)TRMT5 (221952_x_at)CDKN2C (204159_at)FANCD2 (242560_at)MLF1IP (218883_s_at)NEK2 (204641_at)SMC4 (201663_s_at)FANCI (223785_at)−−− (229128_s_at)−−− (1558019_at)CBX5 (226085_at)DNAJC9 (213092_x_at)CASC5 (228323_at)RFC3 (204127_at)FANCI (213008_at)HMGB3 (203744_at)FABP5 (202345_s_at)IPO5 (211954_s_at)PRRX1 (226695_at)KCNK2 (210261_at)HMGB1 (200679_x_at)SFRS3 (202899_s_at)HMGN2 (208668_x_at)HNRNPH3 (210110_x_at)C13orf37 (228530_at)GMNN (218350_s_at)CCNB1 (214710_s_at)TYMS (202589_at)ENPP1 (205066_s_at)FAM111B (1557129_a_at)SMCR8 (231701_s_at)GINS2 (221521_s_at)GGH (203560_at)ANP32B (201306_s_at)MCM10 (220651_s_at)CDC20 (202870_s_at)TMEM48 (218073_s_at)ADCY3 (209321_s_at)TMEM48 (234672_s_at)STIL (205339_at)GTSE1 (204318_s_at)ATAD2 (222740_at)GINS1 (206102_at)ELOVL2 (220029_at)EPR1 (1555826_at)BIRC5 (202095_s_at)WHSC1 (209053_s_at)SGOL2 (235425_at)SNRPG (205644_s_at)PLEKHO1 (218223_s_at)CEP55 (218542_at)CDCA5 (224753_at)PTTG1 (203554_x_at)RFC5 (203209_at)ITGB3BP (205176_s_at)CDC6 (203967_at)TPX2 (210052_s_at)LMNB1 (203276_at)PDK1 (206686_at)CCNA2 (213226_at)AURKA (208079_s_at)PSMC3IP (213951_s_at)NEK2 (211080_s_at)ZNF367 (229551_x_at)PELI2 (219132_at)TOP2A (201291_s_at)KIF11 (204444_at)−−− (229339_at)TCF19 (223274_at)CASC5 (1552682_a_at)H2AFZ (200853_at)CDC7 (204510_at)TMPO (224944_at)PTGER2 (206631_at)C13orf3 (227165_at)NEURL1B (225355_at)ASPM (239002_at)MELK (204825_at)KIF14 (236641_at)CDCA7 (224428_s_at)HNRNPD (221481_x_at)CDC2 (203213_at)HMMR (209709_s_at)PLK4 (204886_at)BUB1 (209642_at)HAS2 (230372_at)DHFR (202532_s_at)DEK (200934_at)RRM1 (201477_s_at)RNASEH2A (203022_at)CDC2 (210559_s_at)NDC80 (204162_at)MAD2L1 (203362_s_at)BUB1B (203755_at)DARS (201623_s_at)RACGAP1 (222077_s_at)HMGB1 (200680_x_at)MRPL3 (208787_at)HNRNPA3 (211932_at)H3F3B (211999_at)DEPDC1 (222958_s_at)KIF4A (218355_at)HMGB1 (214938_x_at)LOC728264 (1558828_s_at)SYTL2 (225496_s_at)THBS2 (203083_at)COL15A1 (203477_at)EDNRA (204464_s_at)GNG2 (224964_s_at)PBX1 (212151_at)COL5A3 (52255_s_at)HHIP (223775_at)GAS7 (210872_x_at)HBE1 (205919_at)COL14A1 (212865_s_at)NDRG1 (200632_s_at)PRR16 (220014_at)TSPAN2 (214606_at)SEMA4D (203528_at)−−− (228620_at)CDC5L (222179_at)DPYSL3 (201431_s_at)DBNDD2 /// SYS1−DBNDD2 (218094_s_at)FNBP1L (215017_s_at)FAM49A (208092_s_at)TCF4 (203753_at)TNFAIP3 (202644_s_at)COL14A1 (216866_s_at)LOC100132181 (225046_at)ROR2 (205578_at)TCF4 (213891_s_at)PRTFDC1 (222803_at)−−− (235494_at)C4orf27 (218646_at)PNPLA4 (209740_s_at)RSBN1L (226387_at)C10orf58 (224435_at)MTF2 (209704_at)FBN2 (203184_at)CDC45L (204126_s_at)−−− (227921_at)DLG3 (207732_s_at)CHEK1 (205393_s_at)PRPF38A (1553709_a_at)COL8A1 (214587_at)C6orf176 (230251_at)−−− (1566446_at)ENPEP (204845_s_at)F2RL1 (206429_at)TRBC1 /// TRBC2 (211796_s_at)TMEM119 (227300_at)BCL3 (204908_s_at)BRMS1L (224484_s_at)HNRNPUL1 (208713_at)ZNF334 (220022_at)PLEKHA2 (217677_at)FLJ36848 (231698_at)ZNF462 (226575_at)−−− (241789_at)ROD1 (224618_at)ALDH1B1 (209646_x_at)RBBP4 (210371_s_at)NRAS (202647_s_at)GTSE1 (204317_at)HIST1H3C (208577_at)EGR1 (201693_s_at)−−− (215345_x_at)METTL4 (219698_s_at)CENPI (1555046_at)RFFL (237919_at)−−− (229284_at)LZIC (226081_at)ANKRD28 (229307_at)C10orf140 (1559265_at)RUFY2 (233191_at)ROD1 (214698_at)COMMD4 (209132_s_at)JRK (216309_x_at)HOXB4 (231767_at)PDS5B (242302_at)FAP (209955_s_at)LRIG1 (238339_x_at)CUGBP2 (202158_s_at)CDKN1C (213348_at)C10orf58 (232662_x_at)IL1B (205067_at)PLXDC1 (219700_at)CNPY3 (217931_at)LONP1 (209017_s_at)SAV1 (222573_s_at)PKNOX2 (219046_s_at)TACSTD2 (202286_s_at)ESCO2 (235178_x_at)COL5A3 (218975_at)PDE4D (204491_at)ALDOC (202022_at)G2E3 (223257_at)ZNF532 (220617_s_at)−−− (244047_at)RGS17 (220334_at)SCD (211162_x_at)PMCHL1 (217123_x_at)−−− (228243_at)ZNF643 (207219_at)HYI (223769_x_at)SESTD1 (228088_at)LAYN (1556885_at)NXT2 (209628_at)MTMR1 (213511_s_at)CDC5L (209056_s_at)LOC100127983 (1557961_s_at)POLE3 (208828_at)FAM101B (226876_at)CDKAL1 (214877_at)SLC6A15 (232263_at)−−− (242655_at)HIST1H2BH (208546_x_at)WHSC1 (223472_at)ANKRD32 (1558076_at)CDC25A (204696_s_at)INCENP (219769_at)MAGOHB (218894_s_at)PEX13 (1558163_at)GULP1 (204235_s_at)SMCHD1 (1558747_at)−−− (213048_s_at)HNRPDL (1554678_s_at)−−− (243136_at)CWF19L2 (237040_at)DIS3L (235005_at)−−− (207465_at)C5orf34 (229886_at)SLC8A1 (238546_at)SP1 (214732_at)SLC27A5 (219733_s_at)FAM166A (233971_at)DOT1L (226201_at)SMCHD1 (241621_at)FRMD4A (208476_s_at)ZBTB24 (1554037_a_at)CREB1 (225565_at)GNB4 (223487_x_at)−−− (235267_at)NOTCH3 (203238_s_at)PAQR8 (226423_at)LRRC15 (1552960_at)DR1 (209187_at)−−− (243041_s_at)PRPF31 (202408_s_at)CA9 (205199_at)PHGDH (201397_at)GPX7 (213170_at)KLHL23 (241682_at)KIAA0146 (212523_s_at)BAALC (222780_s_at)CNTLN (1559005_s_at)−−− (1560258_a_at)−−− (1562777_at)FAM162A (220942_x_at)NUCKS1 (224582_s_at)PRR11 (219392_x_at)HNRNPH2 /// RPL36A /// RPL36AP37 (201406_at)NUCKS1 (222027_at)DPYSL3 (201430_s_at)HIST1H4B (206951_at)HIST1H4C (205967_at)HIST1H2AD /// HIST1H3D (214522_x_at)ACD (204617_s_at)PTBP1 (212015_x_at)ENO1 (217294_s_at)DAZAP1 (229813_x_at)MCM4 (212141_at)DEPDC1B (226980_at)ZNF93 (215758_x_at)CSE1L (201111_at)LSM5 (211747_s_at)DAZAP1 (226620_x_at)APCDD1 (225016_at)−−− (1562921_at)SUV39H2 (219262_at)PPIL5 (235113_at)DSE (218854_at)BTG3 (213134_x_at)SIRT1 (218878_s_at)RBX1 (218117_at)LOC729683 (236497_at)FRMD5 (1569470_a_at)FLJ39051 (230999_at)NUP50 (218294_s_at)MRPS15 (223291_at)SET (210231_x_at)−−− (220729_at)CTAG1A /// CTAG1B (210546_x_at)RSBN1L (228963_at)HAUS3 (210054_at)SIP1 (210779_x_at)SFRS1 (201742_x_at)SET (200630_x_at)−−− (228714_at)SILV (209848_s_at)−−− (213802_at)FAM13C (1554547_at)IL1B (39402_at)SMC5 (212927_at)IFT81 (219372_at)−−− (231067_s_at)ZNF395 (221123_x_at)CREB1 (225572_at)TNRC6A (224704_at)SLC9A3R1 (201349_at)GKAP1 (234192_s_at)LRFN5 (230644_at)CLDN23 (228706_s_at)−−− (243176_at)EFNB3 (205031_at)PKNOX2 (63305_at)EYA2 (209692_at)C4orf43 (218513_at)RFFL (228980_at)−−− (228218_at)IFT80 (226098_at)SMAD1 (227798_at)NID1 (202008_s_at)GAL3ST4 (219815_at)HAUS7 (213334_x_at)BNC2 (235723_at)USP44 (224048_at)BRCA2 (208368_s_at)TMEM14B (221452_s_at)WDR12 (218512_at)DISP1 (235466_s_at)RTN4IP1 (1555679_a_at)MDN1 (212693_at)TSEN15 (225399_at)C6orf168 (232067_at)FBXO45 (225099_at)ERLIN1 (202441_at)−−− (227210_at)DIAPH1 (209190_s_at)FAM54A (234944_s_at)TIPIN (219258_at)C3orf14 (219288_at)ROD1 (224617_at)C6orf182 (1554019_s_at)TMEM97 (212281_s_at)ZNF286A /// ZNF286B (227077_at)CREB3L2 (212345_s_at)−−− (243252_at)XRCC5 (208642_s_at)CEP152 (239413_at)KIAA1429 (243927_x_at)TIMM9 (218316_at)ZNF100 (238791_at)KLF12 (238940_at)UTP11L (218235_s_at)TMTC4 (1554102_a_at)−−− (232331_at)POLR2D (203664_s_at)SS18L2 (218283_at)−−− (216585_at)PPP2R3A (209633_at)MSH3 (229662_at)RBM28 (218593_at)PTPN3 (203997_at)−−− (235171_at)C19orf2 (222266_at)FBXO4 (223493_at)−−− (242150_at)ZFHX4 (241700_at)RICS (210791_s_at)−−− (235363_at)ZBTB38 (219221_at)MPHOSPH9 (206205_at)−−− (228605_at)LOC81691 (208107_s_at)−−− (230403_at)ZSCAN16 (219676_at)−−− (243868_at)−−− (242924_at)RBBP4 (217301_x_at)ARL10 (1553207_at)ZNF100 (1569637_at)SETMAR (206554_x_at)GART (212379_at)BCKDHA (202331_at)−−− (227881_s_at)KIAA1009 (206005_s_at)ARID1A (210649_s_at)TLE1 (203221_at)ADSL (210250_x_at)USP25 (223167_s_at)MPHOSPH9 (237158_s_at)NGDN (213794_s_at)PBRM1 (223900_s_at)DOCK11 (226875_at)CCDC41 (219644_at)SEPT6 (212415_at)SF3A2 (37462_i_at)−−− (242699_at)ARRB2 (203388_at)−−− (1565628_at)OR2A20P /// OR2A5 /// OR2A9P (222290_at)HADH (211569_s_at)CHML (1565949_x_at)TOP2A (237469_at)−−− (239798_at)PLEKHA5 (220952_s_at)CRIPT (222702_x_at)VAPA (225198_at)FAM65B (209829_at)EFS (204400_at)−−− (226197_at)SPOCK1 (202363_at)SULF1 (212353_at)TNFAIP6 (206025_s_at)CAND1 (208838_at)FANCL (218397_at)MYOCD (237206_at)BAALC (218899_s_at)C14orf145 (1557756_a_at)ATP8B1 (226302_at)RBM27 (225326_at)ITGB8 (226189_at)EPB41 (1554481_a_at)C1orf199 (225786_at)HEATR2 (218460_at)−−− (237245_at)PGBD1 (235411_at)−−− (243888_at)NUPL1 (241425_at)TFDP2 (203589_s_at)PIP4K2A (212829_at)SLC19A1 (1555953_at)−−− (230610_at)−−− (236180_at)IDH2 (210045_at)LOC729446 (238043_at)SLCO3A1 (227367_at)DLEU2 (1563229_at)CTBP2 (201218_at)AGPAT4 (228667_at)PDK3 (206348_s_at)ST6GALNAC3 (235334_at)SFXN2 (227560_at)ALS2CR4 (1553956_at)HIVEP3 (235122_at)−−− (229244_at)CEP70 (224150_s_at)CNTNAP3 /// LOC643827 (223796_at)ATP2B1 (212930_at)PGAP1 (220576_at)LSM8 (219119_at)C18orf10 (212055_at)TMEM133 (223595_at)AGPAT5 (232007_at)NHLRC2 (219353_at)CP110 (204662_at)PRKRIP1 (1564166_s_at)HMGXB4 (212597_s_at)ZNF826 (1569191_at)GDAP1 (226271_at)LARP7 (212785_s_at)ZMYND8 (209049_s_at)PHF20 (235389_at)CTAG2 (215733_x_at)−−− (241776_at)ETAA1 (219216_at)CEP192 (218827_s_at)SLC25A5 (200657_at)DPH5 (219590_x_at)DNA2 (213647_at)−−− (1560739_a_at)ZC3H13 (227536_at)SRBD1 (219055_at)C20orf117 (207711_at)NOL9 (1554082_a_at)PDCD2 (204025_s_at)ZNF678 (242923_at)LYPD6 (227763_at)PHF19 (227211_at)KREMEN1 (234843_s_at)−−− (239519_at)KHSRP (204372_s_at)TFDP1 (242939_at)−−− (236090_at)IMMP1L (230556_at)ARL6IP6 (225711_at)LOC646576 (236632_at)VRK2 (205126_at)USP37 (226730_s_at)CXorf57 (219355_at)RIF1 (241820_at)H2AFV (227085_at)SLC43A3 (210692_s_at)ERI1 (231852_at)FAM33A (225686_at)NUP160 (214962_s_at)TFDP2 (203588_s_at)TCF3 (213730_x_at)MDC1 (203062_s_at)AADAT (223593_at)BIRC5 (210334_x_at)TMEM200B (227386_s_at)SASS6 (231895_at)PDGFA (205463_s_at)PIM1 (209193_at)ELOVL2 (213712_at)RPL22L1 (225541_at)−−− (238729_x_at)RPA3 (209507_at)ADARB1 (207999_s_at)RBP1 (203423_at)FBLN1 (202995_s_at)−−− (226458_at)NDE1 (227249_at)RBL1 (1559307_s_at)−−− (225750_at)LOC284952 (1557267_s_at)LAMA2 (205116_at)LOC100131914 (240382_at)−−− (230312_at)IPO9 (217885_at)EML4 (228673_s_at)BUB3 (209974_s_at)C9orf64 (235940_at)TSPYL5 (213122_at)LRRC37A4 (220220_at)SMCHD1 (212569_at)−−− (240247_at)ZNF506 (238493_at)NUP54 (218256_s_at)−−− (226444_at)AGTPBP1 (204500_s_at)USP37 (232033_at)TDP1 (226044_at)−−− (228850_s_at)FANCI (213007_at)PHF17 (225816_at)−−− (229333_at)ORC6L (219105_x_at)PCNA (201202_at)−−− (1563357_at)RNF144A (204040_at)DARS (201624_at)PABPC4L (238865_at)ANP32E (221505_at)TPI1 (200822_x_at)CENPK (222848_at)MLLT4 (224685_at)TRA2B (200893_at)−−− (229347_at)NDUFA12 (223244_s_at)CNOT7 (225053_at)MCM8 (224320_s_at)CCDC18 (236665_at)TTPAL (228031_at)CENPQ (219294_at)COQ2 (213379_at)SFRS3 (208673_s_at)DSN1 (219512_at)ZAK (218833_at)PPP2R3A (209632_at)−−− (230130_at)MUS81 (218463_s_at)LOC100129034 (225214_at)C7orf68 (218507_at)FANCB (1553244_at)ALG10 (1552306_at)SETD2 (215038_s_at)CLDN23 (228707_at)−−− (238041_at)RAD54B (219494_at)PPP1R14A (227006_at)HOXA5 (213844_at)SOCS2 (203373_at)PRPS2 (203401_at)AKAP7 (205771_s_at)CENPC1 (204739_at)DONSON (221677_s_at)PTPN2 (213136_at)PHF17 (218517_at)RBBP7 (201092_at)AURKA (208080_at)SIM2 (206558_at)CENPA (210821_x_at)RAD18 (223417_at)−−− (241569_at)HAUS5 (213054_at)−−− (239331_at)ZNF107 (205739_x_at)DHX15 (201385_at)FBLN7 (229247_at)BCL2 (203685_at)TOP2B (211987_at)GPN3 (218461_at)EXOSC2 (209527_at)CPS1 (217564_s_at)NSMCE4A (211376_s_at)ARAP3 (218950_at)GNG2 (223943_s_at)LIFR (225575_at)HNRNPA3 (211929_at)ZNF300 (228144_at)QSER1 (226265_at)−−− (1556904_at)SMC1A (201589_at)MTMR4 (212277_at)GART (210005_at)ZNF90 (1562133_x_at)GSTO2 (227163_at)PFTK1 (204604_at)ZNF639 (222623_s_at)ZNF217 (203739_at)−−− (1560271_at)ANKRD28 (213035_at)USP28 (1552678_a_at)−−− (236513_at)GJC1 (228776_at)FAM54A (228069_at)IER5 (218611_at)MRPS31 (212603_at)AHCTF1 (226115_at)SMC4 (215623_x_at)BUB1 (216277_at)LASS6 (212446_s_at)−−− (242723_at)DNMT1 (201697_s_at)ZNF202 (204327_s_at)WDR34 (224715_at)PDE7A (230500_at)NIPBL (212483_at)AURKB (239219_at)RBBP4 (237333_at)CCDC123 (1560599_a_at)LOC100129112 (241180_at)UMPS (215165_x_at)C12orf32 (225837_at)GDAP1 (226269_at)SFRS1 (211784_s_at)−−− (239253_at)SFRS1 (227164_at)WWC1 (213085_s_at)DDIT4L (228057_at)SDC1 (201286_at)CDC2 (203214_x_at)C11orf82 (228281_at)ZNF711 (207781_s_at)MEIS2 (207480_s_at)EXOSC8 (215136_s_at)LSM3 (202209_at)−−− (232198_at)MYB (204798_at)CSE1L (210766_s_at)PARP1 (208644_at)BRCA1 (204531_s_at)C10orf58 (228155_at)NEFH (204412_s_at)ZNF501 (1562386_s_at)DCLRE1B (219490_s_at)KNTC1 (206316_s_at)HSPA12A (214434_at)NRAS (224985_at)B3GALNT1 (211379_x_at)TSEN15 (225400_at)−−− (239058_at)RFC3 (204128_s_at)STMN1 (200783_s_at)DSCC1 (219000_s_at)HDGF (200896_x_at)LSM5 (202904_s_at)HNRNPA3 /// HNRNPA3P1 (206809_s_at)HNRNPM (1555844_s_at)LSM6 (205036_at)GUCY1B3 (203817_at)KITLG (226534_at)LIG1 (202726_at)TIFA (226117_at)MTP18 (223172_s_at)LOC100133577 (226014_at)PTBP1 (202189_x_at)CHAF1B (204775_at)CCDC18 (232362_at)SFRS2 (200753_x_at)PAICS (201013_s_at)DCN (240556_at)MIRHG1 (232291_at)EMP2 (225079_at)PYGL (202990_at)ASXL1 (212237_at)STRBP (223245_at)−−− (1565627_a_at)RAC2 (213603_s_at)RPA1 (201528_at)RFC1 (209085_x_at)C8orf59 (226165_at)ZWILCH (222606_at)GPR126 (213094_at)HELLS (227349_at)ATAD2 (228401_at)−−− (238852_at)SOCS1 (213337_s_at)−−− (225716_at)NUP35 (225470_at)NR2F2 (215073_s_at)FAM111A (218248_at)MIRHG2 (229437_at)PMCH (206942_s_at)CASP2 (226032_at)CBX5 (212126_at)SPC24 (235572_at)MKI67 (212022_s_at)PRC1 (218009_s_at)SOX11 (204914_s_at)C6orf173 (226936_at)CDKN3 (209714_s_at)PTMA (211921_x_at)NCAPH (212949_at)HELLS (220085_at)MCM10 (223570_at)CKAP2L (229610_at)NUSAP1 (218039_at)MTF2 (209705_at)EME1 (234465_at)CDC25C (205167_s_at)−−− (242486_at)SLCO3A1 (219229_at)CCDC138 (235644_at)SMC4 (201664_at)KIF20B (205235_s_at)CDH2 (203440_at)ADAMTS6 (237411_at)EPS8 (202609_at)CA12 (215867_x_at)HNRNPH3 (207127_s_at)LOC91431 (228859_at)CDT1 (228868_x_at)CENPJ (234023_s_at)USP1 (202412_s_at)PLK4 (204887_s_at)DCLRE1B (222889_at)KIAA0101 (211713_x_at)NUDT15 (219347_at)KIAA1524 (1553810_a_at)WHSC1 (209054_s_at)−−− (235609_at)HNRNPD (221480_at)FKBP5 (224840_at)FAM64A (221591_s_at)−−− (236312_at)ERCC6L (219650_at)TOP2A (201292_at)WDHD1 (216228_s_at)HMGB2 (208808_s_at)KIF14 (206364_at)BUB1 (215509_s_at)AGPAT5 (218096_at)CASC5 (1552680_a_at)CKS2 (204170_s_at)HMGB1 (224731_at)CTCFL /// HMGB1 /// HMGB1L1 /// HMGB1L10 /// LOC100132863 (216508_x_at)HIST1H1B (214534_at)NRIP1 (202600_s_at)SF3B3 (200687_s_at)TCF12 (208986_at)HMGB1 (224734_at)CACYBP (210691_s_at)−−− (208655_at)−−− (220682_s_at)HHIP (1556037_s_at)MTF2 (203347_s_at)LOC643287 /// PTMA (216515_x_at)SACS (213262_at)RAD21 (200608_s_at)BRCA2 (214727_at)WEE1 (212533_at)PEG10 (212094_at)CSRP2 (207030_s_at)SPHK1 (219257_s_at)HNRNPD (200073_s_at)SIX1 (228347_at)CDCA2 (236957_at)DPF3 (238532_at)NCAPG (218662_s_at)SNRPE (203316_s_at)TBX3 (229576_s_at)TUBGCP3 (1554086_at)ZNF253 (206900_x_at)RPAIN (228288_at)SYNPO2L (219804_at)PLEKHA8 (232212_at)FOXD1 (213972_at)MLLT10 (230122_at)TBL1X (201868_s_at)UBE2N (201523_x_at)G0S2 (213524_s_at)CENPV (230436_s_at)CDC42EP4 (218062_x_at)C3orf59 (227599_at)KIF23 (244427_at)−−− (240698_s_at)TYW3 (227141_at)EEF1E1 (204905_s_at)ELF4 (31845_at)−−− (226546_at)PLEK2 (218644_at)TPRKB (219030_at)IMMP1L (229025_s_at)−−− (228778_at)−−− (231963_at)RPL13 (212191_x_at)CA5BP (239106_at)CEP110 (205642_at)CCNJ (219470_x_at)DLEU2 (216870_x_at)−−− (242605_at)TMEM106C (201764_at)ITGB8 (211488_s_at)−−− (228827_at)TAF5L (213654_at)RNFT2 (221909_at)DEPDC1B (233115_at)FNTB (225851_at)CHRAC1 (231764_at)HYLS1 (227687_at)IRAK3 (220034_at)UCK2 (209825_s_at)WWC1 (216074_x_at)TBC1D1 (212350_at)ATIC (208758_at)MRTO4 (220688_s_at)TAF9B (221617_at)TTLL5 (214672_at)NR2F2 (209121_x_at)PCF11 (203378_at)GSTCD (1554518_at)MATN2 (202350_s_at)CASP2 (208050_s_at)KPNB1 (208974_x_at)C15orf23 (225300_at)USP13 (205356_at)ZFHX4 (219779_at)PBRM1 (220355_s_at)STRBP (223246_s_at)HMGB3 (225601_at)CDC25B (201853_s_at)TUBB (211714_x_at)SNCAIP (219511_s_at)PPIF (201489_at)NUB1 (1569030_s_at)IRS1 (235392_at)SFRS1 (208863_s_at)TNPO3 (214550_s_at)PTPN2 (213137_s_at)CYB5R2 (220230_s_at)CDC6 (203968_s_at)HN1L (212115_at)PPP1R14B (212680_x_at)−−− (230910_s_at)CHST14 (226314_at)NARG1L (1555450_a_at)SH2D4A (219749_at)CALM3 (200623_s_at)HIST1H1C (209398_at)RANBP1 (221915_s_at)B3GNT5 (1554835_a_at)ENPP1 (228952_at)TAF5 (210053_at)RAD51L1 (216880_at)PLEKHG4B (236255_at)RAB31 (217762_s_at)C6orf125 (224448_s_at)RPS21 (214097_at)EML4 (223069_s_at)FAM46B (229518_at)C5orf13 (238411_x_at)DLEU2 (242854_x_at)KHDRBS1 (201488_x_at)GUF1 (218884_s_at)SDC1 (201287_s_at)SLIT2 (209897_s_at)HN1 (217755_at)NHP2 (209104_s_at)RECQL4 (213520_at)−−− (229795_at)CTBP2 (210554_s_at)MRPL11 (219162_s_at)PDE8A (1552931_a_at)AQR (212584_at)YWHAH (201020_at)WHSC1 (222778_s_at)GNG2 (1555766_a_at)CHD4 (201183_s_at)SRF (202401_s_at)RQCD1 (1553510_s_at)TCF4 (212382_at)E2F2 (228361_at)C18orf54 (1553652_a_at)C5orf23 (219054_at)SFRS2 (200754_x_at)H3F3A /// H3F3B /// LOC440926 (213828_x_at)

−2 −1 0 1 2Value

03000 Color Keyand HistogramCount

0809_PA

(3)1_nuH

_IM

R90_P

D28_r1_2.C

EL

0809_PA

(3)2_nuH

_IM

R90_P

D28_r2_2.C

EL

0809_PA

(3)3_nuH

_IM

R90_P

D28_r3_2.C

EL

0809_PA

(3)4_nuH

_IM

R90_P

D28_r4_2.C

EL

0809_PA

(3)5_nuH

_IM

R90_P

D28_r5.C

EL

0809_PA

(3)6_nuH

_IM

R90_P

D90_r1.C

EL

0809_PA

(3)7_nuH

_IM

R90_P

D90_r2.C

EL

0809_PA

(3)8_nuH

_IM

R90_P

D90_r3.C

EL

0809_PA

(3)9_nuH

_IM

R90_P

D90_r4.C

EL

0809_PA

(3)10_nuH

_IM

R90_P

D90_r5.C

EL

ABCF1 (200045_at)NFKB1 (209239_at)IL1RAP (210233_at)TNFAIP6 (206025_s_at)CDO1 (204154_at)C5 (205500_at)NMI (203964_at)AFAP1L2 (226829_at)NOD1 (224190_x_at)HDAC9 (205659_at)RIPK2 (209545_s_at)MGLL (225102_at)CXCR4 (217028_at)CXCL10 (204533_at)CHST2 (203921_at)CFH /// CFHR1 (215388_s_at)APOL3 (221087_s_at)SCG2 (204035_at)PTX3 (206157_at)IL10RB (209575_at)CXCL1 (204470_at)CCL26 (223710_at)AOX1 (205083_at)TACR1 (230908_at)IL8 (211506_s_at)GPR68 (229055_at)CXCL11 (211122_s_at)NFE2L1 (214179_s_at)TPST1 (204140_at)ANXA1 (201012_at)

−1 0 1Value

0

Color Keyand Histogram

Co

un

t

Proliferating! Senescent!

D!

0809

_PA(

3)1_

nuH

_IM

R90

_PD

28_r

1_2.

CEL

0809

_PA(

3)2_

nuH

_IM

R90

_PD

28_r

2_2.

CEL

0809

_PA(

3)3_

nuH

_IM

R90

_PD

28_r

3_2.

CEL

0809

_PA(

3)4_

nuH

_IM

R90

_PD

28_r

4_2.

CEL

0809

_PA(

3)5_

nuH

_IM

R90

_PD

28_r

5.C

EL

0809

_PA(

3)6_

nuH

_IM

R90

_PD

90_r

1.C

EL

0809

_PA(

3)7_

nuH

_IM

R90

_PD

90_r

2.C

EL

0809

_PA(

3)8_

nuH

_IM

R90

_PD

90_r

3.C

EL

0809

_PA(

3)9_

nuH

_IM

R90

_PD

90_r

4.C

EL

0809

_PA(

3)10

_nuH

_IM

R90

_PD

90_r

5.C

EL

ABCF1 (200045_at)NFKB1 (209239_at)IL1RAP (210233_at)TNFAIP6 (206025_s_at)CDO1 (204154_at)C5 (205500_at)NMI (203964_at)AFAP1L2 (226829_at)NOD1 (224190_x_at)HDAC9 (205659_at)RIPK2 (209545_s_at)MGLL (225102_at)CXCR4 (217028_at)CXCL10 (204533_at)CHST2 (203921_at)CFH /// CFHR1 (215388_s_at)APOL3 (221087_s_at)SCG2 (204035_at)PTX3 (206157_at)IL10RB (209575_at)CXCL1 (204470_at)CCL26 (223710_at)AOX1 (205083_at)TACR1 (230908_at)IL8 (211506_s_at)GPR68 (229055_at)CXCL11 (211122_s_at)NFE2L1 (214179_s_at)TPST1 (204140_at)ANXA1 (201012_at)

−1 0 1Value

0

Color Keyand Histogram

Cou

nt

Supplementary Figure 2 Altered gene expression in senescence. (A) Heatmap showing hierarchical clustering of gene expression in proliferating and senescent cells. Significant changed probes of fold change >= 1.5 and BH-fdr(tt) <= 0.05. (B) Gene set enrichment analysis of downregulated genes with normalized enrichment score (NES) and family wise-error rate (FWER) p-value (C) Gene set enrichment plot of cell cycle process

in senescence, top part shows the enrichment value for each gene in this class and the bottom part, the ranked list metric of these genes. (D) Heatmap showing hierarchical clustering of expression of genes in gene set “inflammatory response” (http://www.broadinstitute.org/gsea/msigdb/cards/INFLAMMATORY_RESPONSE.html) in proliferating and senescent cells. Significant changed probes of fold change >= 1.5 and BH-fdr(tt) <= 0.05.

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

WWW.NATURE.COM/NATURECELLBIOLOGY 3

Chr 1!

Scalechr1:

100 Mb hg1850,000,000 100,000,000 150,000,000 200,000,000

Hazels Bisulphite Seq

100 -

0 _

Hazels Bisulphite Seq

100 -

0 _

Hazels Bisulphite Seq

100 -

0 _

Replicate!Pair 1!

Replicate!Pair 2!

Replicate!Pair 3!

% m

eth!

% m

eth!

% m

eth!

Supplementary Figure 3!

A!

B!

Supplementary Figure 3 Concordance of replicates and methylation changes across all chromosomes. (A) Overlayed percentage methylated basecall plots of proliferating (blue) and senescent (orange) for each replicate pair. Chromosome 1 (chr 1) is shown as a representative region. (B) Difference p plots of all chromosomes (chr).

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

4 WWW.NATURE.COM/NATURECELLBIOLOGY

A!

Supplementary Figure 4!

B!

Proliferating gene expression!

Met

hyla

tion

diffe

renc

e (S

en –

Pro

lif)!

-0.4!

-0.2!

0.0!

0.2!

0.4!

5 10!-0.4!

-0.2!

0.0!

0.2!

0.4!

C!

-0.4!

-0.2!

0.0!

0.2!

0.4!D!

-4! -2! 0 2Ln fold change expression!

-0.4!

-0.2!

0.0!

0.2!

0.4!

4

F!

-4! -2! 0! 2! 4!

E!

-4! -2! 0! 2!-0.4!

-0.2!

0.0!

0.2!

0.4!

4!

Proliferating gene expression!

Proliferating gene expression!

Ln fold change expression! Ln fold change expression!

Met

hyla

tion

diffe

renc

e (S

en –

Pro

lif)!

Met

hyla

tion

diffe

renc

e (S

en –

Pro

lif)!

Met

hyla

tion

diffe

renc

e (S

en –

Pro

lif)!

Met

hyla

tion

diffe

renc

e (S

en –

Pro

lif)!

Met

hyla

tion

diffe

renc

e (S

en –

Pro

lif)!

Promoter! Gene body!

Promoter + CpG Island! Promoter!

Gene Body! Promoter + CpG Island!

05 10!0

5 10!0

G

-4! -2! 0! 2!-0.4!

-0.2!

0.0!

0.2!

0.4!

4!Ln fold change expression!

Met

hyla

tion

diffe

renc

e (S

en –

Pro

lif)!

Promoter + CpG Island (expressed genes)!

-0.4!

-0.2!

0.0!

0.2!

0.4!

Supplementary Figure 4 Methylation changes relative to gene expression. (A) - (C) Relative level of gene expression in proliferating cells against the difference in methylation between proliferating and senescent cells (Sen-Prolif). Methylation was scored at promoters, gene bodies and promoters containing CpG islands defined in UCSC, as indicated. (D)-(F) Ln fold change of gene expression between proliferating and senescent cells

(positive values, increased expression in senescence; negative values, decreased expression in senescence) against the difference in methylation between proliferating and senescent cells (Sen-Prolif). Methylation was scored at promoters, gene bodies and promoters containing CpG islands, as indicated. (G) Same analysis as in F, but only for genes expressed above the median level of expression in proliferating cells.

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

WWW.NATURE.COM/NATURECELLBIOLOGY 5

Supplementary Figure 5!

Supplementary Figure 5 Promoters of repressed cell cycle genes are methylated in senescence. Plots of differential methylation versus position up and downstream of TSS (-5kb to +5kb) for selected genes. Y-axis is a differential methylation score that ranges from -1 to 1, denoting complete

hypomethylation and hypermethylation, respectively. The full list of genes is in Supplementary Dataset 3. In each plot, the vertical line marks the TSS. Fold change (log2) gene expression of each gene is indicated in green. For each gene, data from all 3 replicates is shown.

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

6 WWW.NATURE.COM/NATURECELLBIOLOGY

Supplementary Figure 6!

25!30!35!40!45!50!55!

0! 20! 40! 60!Days!

Cum

ulat

ive

PD!

EV!shDNMT1-a!shDNMT1-b!

DNMT1!

ACTIN!

EV!

shDNMT1-a!

shDNMT1-b!

SA β-gal!

% c

ells

HIR

A/PM

L co

loca

lisat

ion!

0!

20!

40!

60!

80!

100!

A! B!

D!

+! +!-! -!RT! +! -!

Sat 2!

APRT!

E!

C!

G

% C

yclin

A +

ve!

0!

10!

20!

30!

40!

50!

% c

ells

with

SAH

F!

0!

10!

20!

30!

40!

50!

60!

70!

F!

148!

50!

0!

20!

40!

60!

% h

ypo

cDM

R o

verla

p! b

y hy

po s

DM

R!

(≥10

0kb

DM

Rs

only

)! *

0!

20!

40!

60!

*

% h

ypo

cDM

R o

verla

p! b

y hy

po s

DM

R!

(≥25

0kb

DM

Rs

only

)!

0!

20!

40!

60!%

hyp

o cD

MR

ove

rlap!

by

hypo

sD

MR!

(≥50

0kb

DM

Rs

only

)!

0!

20!

40!

60!

% h

ypo

cDM

R o

verla

p! b

y hy

po s

DM

R!

(≥1M

b D

MR

s on

ly)!

0!

20!

40!

60!

% h

ypo

cDM

R o

verla

p! b

y hy

po s

DM

R!

(≥2M

b D

MR

s on

ly)!

*

* *

H!

Supplementary Figure 6 Knock down of DNMT1 triggers cell senescence, expression of satellite 2 RNA and senescence-associated chromatin changes; and overlap of hypomethylated DMRs in senescence and cancer. (A) Proliferating IMR90 fibroblasts were infected with control lentivirus (EV) or lentivirus encoding independent shRNAs to DNMT1 (shDNMT1-a or shDNMT1-b), selected in puromycin and western blotted to detect DNMT1. (B) Cells from (A) were passaged until proliferation arrest. (C-G) After proliferation arrest, cells from (A) were scored by immunofluorescence for expression of cyclin A (C), expression of SA β-gal. (Scale bar = 30mM), (D), expression of satellite 2 RNA (E), Senescence Associated Heterochromatin

Foci (F) and localization of histone chaperone HIRA to PML bodies (G). For (C), (F) and (G) n=1, but results shown with 2 independent shRNAs and similar results previously reported by others (see main text). (H) Series of graphs assessing percent overlap in total bp over whole genome of indicated features (observed) compared to overlaps calculated for random. Asterisks indicate statistical significance and a p-value of <<0.001. Hypomethylated cancer (hypo cDMR) and senescence DMRs (hypo sDMR) greater than or equal to 100Kb, greater than or equal to 250Kb, greater than or equal to 500Kb, greater than or equal to 1Mb, greater than or equal to 2Mb, as indicated.

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

WWW.NATURE.COM/NATURECELLBIOLOGY 7

Supplementary Figure 7!

Me

thyla

tio

n

0.2

0.5

0.8

!

!

!

! !

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!!!

!

!!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!!!

!

!

!

!

!

!

!

!

!

!

!

!!

!!

!

!

!

!!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!!

!

!

!!

!

!

!!

!!

!

! !

!

!!

!!

!!

!

!

!

!

!

!!

!

!

!!!

!

!

!

!!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!!!

!

!

!

!!

!

!!!

!

!

!

!

!

!

!!

!!!

!!

!

!

!

!

!!!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!!

!

!

!

!

!

!

!!

!!

!!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!!!

!!

!!

!

!

!!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!!

!

!

!!

!

!

!

!

!!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!!!!

!

!

!

!!

!

!

!

!

!

!!

!

!

!

!

!

!

!!!!!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!!

!

!

!!

!!

!!

!!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

chrX: 103,385,363 − 103,386,499

ScalechrX:

CpG: 102

1 kb hg18103,385,000 103,385,500 103,386,000 103,386,500 103,387,000

ESX1

ScalechrX:

CpG: 102

1 kb hg18103,385,000 103,385,500 103,386,000 103,386,500 103,387,000

ESX1

20!

80!

0!

40!Pe

rcen

t met

hyla

tion! TSS!

ESX1, chrX, CpGI 103,385,363-103,386,499!

Me

thyla

tio

n

0.2

0.5

0.8

!

!

!

!

!

!!!

!!

!!

!!

!!!!!!!

!

!

!

!

!

!

!

!!

!

!

!

!!

!

!

!!

!!!

!!!

!

!

!

!!

!

!!!!!

!

!!!!!

!

!

!

!!

!

!!

!

!

!

!

!

!

!

!!!!

!

!!

!!

!

!!!

!!!!!

!!

!!

!!

!

!

!!!!!!!!!

!

!

!

!

!

!

!

!!!!!!!

!

!!!

!

!!!!!

!

!!!!!!!!!

!

!

!!!!!!

!

!!!!!

!

!

!!

!!!

!

!

!

!!!

!

!!!!!!!!

!

!

!

!!!!!!!!

!

!

!

!

!

!!

!!!!!!!!!!!!

!

!!!!!!!!!!!!!!!!

!

!

!

!

!!!!!!!!!!

!

!

!

!!!!!

!

!

!!!!!!!!!!!!!!!

!

!!!!!!!!

!!

!

!

!

!

!

!

!!!!!!!!!!!!!!!!

!

!!!!!!!!!!!!!!!!!!

!

!!!!!!!!!

!!

!!

!

!!

!

!!!!!!!!!!

!

!!!!!!

!

!

!

!!!!

!

!

!!!!

!

!!!!!!

!

!!!

!!

!!!!!!!!!

!

!!!!!!!

!!!

!

!

!

!

!

!

!!!!!

!

!

!!!!

!!

!!

!!

!

!!!

!

!!

!

!

!

!!!!!!

!

!

!

!

!!

!

!

!!

!

!!!!!

!

!

!

!

!

!

!

!!

!

!

!!!

!

!

!

!

!

!!!!!

!!!!

!

!

!

!

!!!

!

!!!

!

!!

!

!!!

!

!!!

!

!

!

!

!!

!

!

!

!!

!

!!!!

!

!

!!

!

!!!

!

!

!

!

!!

!

!

!!!!

!

!!

!

!

!

!

!!!

!

!

!

!

!

!!!

!

!

!

!

!!

!

!

!!!!!

!

!

!

!

!

!

!

!

!

!!

!!

!

!!!!

!!!!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!!

!!!!!

!

!

!

!

!!!!!

!!

!

!

!

!!

!!

!!

!

!

!

!

!!

!

!

!

!

!!!

!

!

!

!

!

!

!

!

!

!

!!!!

!

!

!!

!!

!

!!

!

!!

!

!

!

!

!!!

!

!

!!!

!!

!!!

!

!

!

!

!!!!!!!!!!!

!

!!!!! !!!!!!!!!!!!!!!!!!!!!!!

!!

!!

!

!!!!

!

!!

!

!!

!

!

!

!!!!!!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!!

!

!

!

!

!

!!

!

!!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!!!!

!

!

!

!

!

!

!

!

!!

!

!

!!

!!!

!!!!!

!

!

!

!

!

!

!

!

!!

!

!!

!

!!!

!

!!!

!

!

!

!!

!

!

!!!!!!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!!!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!!!

!

!!!

!

!!!

!!

!!

!

!

!

!!

!

!

!!

!

!

!

!

!!!!!!!

!

!

!

!

!

!!

!

!!!

!

!

!

!

!!!!!!!!!!!!

!!

!!

!

!

!

!

!!

!

!

!!

!

!

!

!

!!

!

!

!!

!!

!!

!

!!

!!!!!!!

!

!!!!!

!

!

!

!!!

!

!!!!!!!

!

!!!!!!!!!!!!!

!!

!!!

!!

!

!

!!!

!!!!!!!!!!!!!!

!

!!!

!!!!!

!

!

!!!!!!!!!!!!

!

!!!!!

!

!

!

!!!!!

!

!

!

!

!

!

!

!

!

!!

!

!!

!!!

!

!

!

!

!!

!

!

!!!!!!!!

!

!

!

!

!

! !

!

!!

!

!!!!!!!!!!

!

!!!

!!

!!!!!!!!!!!!!!!!

!

!!!!!!!!!!!!!!!!!!

!

!!

!!!!! !!!!

!

!

!!!

!!

!!

!

!

!

!!!!

!

!!

!

!

!

!

!

!

!

!!!

!

!

!

!!!!!!!

!

!

!

!!

!

!

!

! !

!

!

!

!

!!

!

!

!

!

!

!

!

!!

!

!

!!

!

!!

!

!

!

!!!

!!

!

!

!

!!

!!

!!

!!!!

!

!!!!!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!!

!

!

!!

!

!!

!

!

!

!

!

!!

!!!!

!!!!

!

!

!

!!!

!

!!!!!!

!!

!!!

!!

!

! !

!

!

!

!

!!

!

!!

!

!

!

!

!!!

!

!

!!!!!!

!!!

!

!!!

!

! !

!

!

!

!

!

!!!!!!

!

!

!

!

!!

!

!

!

!

!

!

!

!!!!

!

!

!

!

!

!!

!

!

!

!!!

!!!

!

!!!! !

!

!!

!!

!

!

!

!

!

!

!!!!!!!!!!!!

!

!!! !!!!!!!!!!!!!!!!!!!!!!

!

!

!!

!

!!

!

!!!!

!

!

!!!!!!

!!!!

!

!

!

!

!!

!

!!

!

!

!!

!

!

!

!

!

!

!

!!

!

!!!

!

!

chr1: 25,128,115 − 25,131,592

Scalechr1:

CpG: 311

2 kb hg1825,128,000 25,128,500 25,129,000 25,129,500 25,130,000 25,130,500 25,131,000 25,131,500 25,132,000

RUNX3

Scalechr1:

CpG: 311

2 kb hg1825,128,000 25,128,500 25,129,000 25,129,500 25,130,000 25,130,500 25,131,000 25,131,500 25,132,000

RUNX3

20!

80!

0!

40!

Perc

ent m

ethy

latio

n!

RUNX3, chr1, CpGI 25,128,115-25,131,592!

Me

thyla

tio

n

0.2

0.5

0.8 !

!

!

!

!

! !! !

!

!!

!!

!

!

!!

!

!

!!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!!

!!

!!!!

!

!!!

!!

!

!

!

!

!

!!!!!!

!!!!!

!!

!!!! !!!! !!!!!!!

!

!!!!

!!!!!!!!!!

!

!!

!

!!!!!!!

!

!!!!!!!!!!

!

! !

!

!!

!

!!

!

!!!

!

!! !

!

!

!

!

!

!

!

!

!!! !!!!!!!

!

!!!!!!!!

!

!!!

!

!

!

!

!

!!!

!

! !!

!

! !!

!!

!

!

!!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!! !!

!

! !

!

!!

!

!

!!

!

!!!!!

!

!

!!

!

!

!!!! !!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!!!!

!!

!! !!!

!

!!!

!!!

!!!!

!!

!

!!!!!!

!!!!

!!!!!!! !!!

!

!!!!!!!! !!!!

!

!

!

!!!

!

!

!

!

!

!!!

!

!!!!

!

!!

!!

!!!

!!

!!!

!

! !!

!

!!!!!!

!

!! !!!!!!!!!!!!

!!

!

!

!

!

!!!

!

!

!!!!!!!

!!

!

!

!!

!!

!!

!

!

!! !

!

!

!

!!

!

!

chr12: 64,868,963 − 64,869,612

Scalechr12:

CpG: 67

500 bases hg1864,868,500 64,869,000 64,869,500 64,870,000

IRAK3

20!

80!

0!

40!

Perc

ent m

ethy

latio

n!

IRAK3, chr12, CpGI 64,868,963-64,869,612!

Meth

yla

tion

0.2

0.5

0.8

!

!

!

!

!

!!

! !

!

!

!

!

!

!

!

!

!

!

!

!

!

!!!

!

!

!!

!

!

!

!

!

!

!

!

!!

!

!!

!

!!

!

!

!

!

!!

!

!!

!

!

!!

!

!

!

!!

!

!!

!

!

!!

!

!

!

!!!!!! !!

!

!!!

!

!

!!!

!

!

!

!

! !!!!!

!

!

!!

!!

!

!

!

!

!!!!!!

!!!

!

!!

!

!

!!!!!!!!!!!!!!!

!

!

!

!!!!!!!!!!

!

!

!!!

!

!

!

! !!

!

!

!!!

!

!

!

!!

!!

!!

!

!

!!

!

!!!!

!!!!

!

!!!!!!!

!!!!! !! !!!

!

!! !

!

!!

!!

!!!!!!!!!!!!!!

!

!!

!

!!

!

!!

! !! !!!! !

!

!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

!

!!!!

!

!!!!!!!!!!

!

!!!!!

!

!!!!!!!!!!!!!!

!

!!!!!!!!!!!!!

!

!!

!

!!!!!!!! !!!!!!!!!!!!!

!

!

!!!!!!!!!!!!!!!!!!!!!!!!!!!

!

!

!

!!!

!

!!!!!!!!!!!!!!! !!!!!

!

!!!!!!!!!!!!!! !!

!

! !!!!!!! !!!!!!!!!!!!

!

!

!

!

!

! !!!

!

!

!

!! !!

!

!

!!

!

!

!

!!!

!!

!!

!!!

!

!

!

!

!

!

!

!

!!

!

!

!

!!!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!!!

!!

!!

!

!

!!

!

!

!

!

!

!

!

!

!

! !!

!

!

!!!!!

!

!

!!!!!

!!

!

!

!

!!

!

!!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!!!

!

!!!!

!

!!!!!

!

!

!!

!

!!!

!!

!

!

!

!

!

!

!

!

!

!

!!!!!!!!!!!!!!!!!!!!!!

!

! !

!

!!!

!

!

!

!!!! !!!!

!

!

!

!

!

!

!

!!!!!

!!

!! !

!

!!!!!!!! !! !

!

!

!

!

!

!!

!

!

!

!!!!!!!!!!!!!!

!

!

!

!!!

!!

!

!

!! !!!! !!!!!!!!!!!

!

!!!!!!!!!!!!!!!!!!!!!!

!

!!! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

!

!!! !

!

!!

!

!!

!

!

!

!!!!

!

!!

!

!!!!!!!!

!

!!!!!!!!

!

!!!!!!!!!!

!

!

!

! !!!!!!!!!!!!!!!!

!

!!

!

!

!

!!!!!

!

!!!!!!!!!!!!!!

!

!!!!!!!

!

!! !!!

!

!! !! !!

!

!

!

! !!!!!!!! ! !!!!!!!!!!

chr17: 45,991,103 − 45,994,278

Scalechr17:

CpG: 249

1 kb hg1845,991,000 45,991,500 45,992,000 45,992,500 45,993,000 45,993,500 45,994,000 45,994,500 45,995,000

CACNA1G

20!

80!

0!

40!

Perc

ent m

ethy

latio

n!

CACNA1G, chr17, CpGI 45,991,103-45,994,278!

Me

thyla

tio

n

0.2

0.5

0.8

!

!

!

!

!

!

!!

!

!!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!!!

!!

!! !!

!

!!!

!

!

!!

!

!!!

!!!!!!!!

!!!

!

!

!

!!!

!!!!

!

!! !!

!

!!! !

!!

!!!!! !!

!

! !!!!

!

!!! !!

!

! !!!!!!!!!!!!

!

!

!!!!!!!!!!!!!!!!!!!!!!!!!!

!!

!

!

!!

!

!!!!

!

!

!

!!!!

!

!!

!

!

!!!!! !! !!

!!

!

!!

!

!! !!!!!!!! !!!!!!

!

!

!

!

!

!!!!!!!

!

!!!

!

!!!!!!!!!!!! ! !!

!

!

! !

!

!!

!

!

!!!!

!

!

!!!!!!!

!

!!

!

!

!!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!!

!

!!

!

!

!

!

!

!

!

!!

!

!

! !!!!!!

!

!!

!

!!

!

!

!

!

!

!!!

!

!

!!!

!

!!!!

!

!!! !

!!!!!

!!!! !

!!!!!!! !

!

!

!

!!!! !!!! !!!!!!!! !!

!

! !

!!

!

!

!

!

!

!

!!

!

!!

!

!

!

!!!

!

!!!!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!!

!!!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

! !!

!

! !! !!!!!!!! !!!!!

!!

!!

!

!

!!

!

!

!

!

!!

!

!!!

!

!!!!!

!

!!!!

!

!!

!

!!!

!

!

!

!

!!

!

!

!

!!!!!!

!

!

! !!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

chr4: 154,928,963 − 154,930,277

Scalechr4:

CpG: 112

1 kb hg18154,928,500 154,929,000 154,929,500 154,930,000 154,930,500 154,931,000

SFRP2

Scalechr4:

CpG: 112

1 kb hg18154,928,500 154,929,000 154,929,500 154,930,000 154,930,500 154,931,000

SFRP2

20!

80!

0!

40!

Perc

ent m

ethy

latio

n!

SFRP2, chr4, CpGI 154,928,963-145,930,277!

Meth

yla

tion

0.2

0.5

0.8

!

!

!!

!!!

!

!

! !

!

!

!

!

!!

!

!

!!!!!!!!!

!!!

!! !!

!

!

!

!

!

!!!!! !!!!!!

!

!!!!!

!

!!!!!!!!!!!!!!

!!

!

!

!!

!

!!!

!

!!

!

!!!!!!!!!!!!

!

!!

!

!!!!!!!!!!!!!!!

!

!!!!!!!!!!!!!!!!

!

!!!!!! !!!!!!!!!!!!!!!!!!!!

!!!!!!!!!!!!

!

!

!

!

!

!

!!!

!

!!

!

!!

!

!! !! !!!!!!!!!! !!!!

!

!!!!!!!!!!!!!

!

!!!!!!!!!

!

!!!!!!! !!!!!!

!

!!!!!

!

!!!!!!!!!!!!!!!

!

!!!!!!!!!

!

! !!!!!!!!

!

!

!

!!!!!!!!!!!!!!!!!!!

!

!!!!!!! !!!!!!!!!!!!!!!!!!!!!!

!

!!!!!!!!!!!!!!!!!

!

!!!

!

!!!!!!!!!! !

!

!!!

!

!!!!!!!! !!!!!

!

!!!!!!!!!!!

!!!!!!

!

!!

!

!! !!!!!!!!!!!

!

!!!!!!!!!!!!!!!!!! !!!!!!!!!

!

!

!!!!

!

!!

!

!!!!!

!

!

!

!

!! !! !

!

!

!

!!!!

!

!

!!!!!!!!!!!! !!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!!!

!

!

!

!

!

!

!!

!

!

!!

!

!

!

!!! !!!!

!

!

!

!!!

!

!!!!!!

!

!!!!!!

!!!!!!

!!

!

!

!!

!

!

!

!!!

!!

!

!

!!!!!!!!

!!!!!!!

!

!

!

!!!!!!!!

!

!!

!

!!

!

!!

!

!!!!

!

!

!!!!!!!! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

!

!

!!

!!!

!

!

!!!!!!!

!

!!

!

! !!

!

!!! !! !!!!!!!!!! !!!!

!

!!!!!!!

!

!!!!!

!

!!!!!!!!!!!!!!!!! !!

!!

!!!!!!!!!!!

!

!!!!!!!!!!!!!!!!!!!!!!!! !!!!

!

!!!!!!!!!!!!!

!

!!!!!!!!!!!!! !!!!!!!!!!!!!!!!!!!!! !

!

!!!!!!!!!!!!!!!!!

!

!!!!!!!!! !!!!!!!!!!!!!!!!!!!!! ! !!!!!!!!!!!!!!!

!

!!!!!!!!!!!!!! !!!!!!!!!!!!!!

!

!!!

!

!!!!! !!!! !! !! !

!

!

!

!

!

!

!

!

!!!

!

!!!!

!

!

!

!

!

!

!

chr16: 11,256,043 − 11,258,304

Scalechr16:

CpG: 202

1 kb hg1811,256,000 11,256,500 11,257,000 11,257,500 11,258,000 11,258,500

SOCS1

20!

80!

0!

40!

Perc

ent m

ethy

latio

n!

SOCS1, chr16, CpGI 11,256,043-11,258,304!

Meth

yla

tion

0.2

0.5

0.8

!

!!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!! !

!

!

!

!

!

!!!!!

!

!!

!!

!!!!!

!

!!!!!!

!!!!!

!

!

!

!

!

!!!!

!

!!!!!!!!! !!!!!

!

!!!!

!

!!!!! !! !!!! !!!!!!!!!!!

!

!!!!!

!

!!!!

!

!!!!!!!!!!!!!!!!!!!!!!!!!

!

!!!!!! !!!! !! !

!

!!!

!

!!!!

!

!!!!!

!

!!!!

!

!!!!!!!!!!!!!!!!!!!!!! !!!!!!!!!! !! !!!!!!! !

!

!!!!!! !!!!!!!

!

!!!!!! ! !! ! !!!!!!!!!!!

!

!

!!!!!!!!!!!!!!!!!

!

!!!

!

!!!!!!!!!!!!!!

!

!!!!!!!!!!!!!!!!

!!!!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!

!

! !

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!

!

!

!

!

!!

!!!!!

!

!

!! !!

!!!!

!

!

!

!!

!

!!

!

!

!

!

!

!

!!

!

!

!!

!!!!!

!

!

!!! !!!!!!!!!!!!!!!! !! !!!! !

!

!!!!!!!!!!!!

!

!

!

!

!

!

!

!! !

!

!! !!!! !!!!!!!!!

!

!!!

!

!!!!!!!!!!!!!!!!!!!!!!!! !

!

!!!!!!

!

! !! !!

!

!!! !!

!

!!!!! !!

!

!!!!

!

!!!!!! !

!

! !!!!!!!!

!

!!!!!!!!!!!!!!!!!!!!!!!!!

!!

!!!!!!

!!

!!

!

!!!

!

!!!

!

!!!!!!!

!

!!!!!

!

!

!!!!

!

!

!

!

!

!

!

!

!

!

!

!

!!

!!

!

!

!

!

!

!

!

!

!

!

!

!!

!

chr9: 21,984,102 − 21,985,910

Scalechr9:

CpG: 176

1 kb hg1821,984,000 21,984,500 21,985,000 21,985,500 21,986,000

CDKN2A

Scalechr9:

CpG: 176

1 kb hg1821,984,000 21,984,500 21,985,000 21,985,500 21,986,000

CDKN2A

20!

80!

0!

40!

Perc

ent m

ethy

latio

n!

CDKN2A, chr9, CpGI 21,984,102-21,985,910!

TSS!

TSS!

TSS!

TSS!

TSS!

TSS!

Supplementary Figure 7 Increased methylation of CpG islands in senescence. Methylation of indicated CpG islands in senescence. Plot of percent methylated basecalls in proliferating (orange) and senescent cells (blue), from whole genome bisulfite sequencing data of 3 replicates of proliferating cells and 3 replicates of senescent cells. The orange and

blue lines show the smoothed average percent methylated basecalls at corresponding CpGs. Individual CpGs are indicated by black ticks along the x-axis. The UCSC genes (blue bar) and CpG islands (green bar) are also shown. The transcription start sites (TSS) are indicated by vertical black arrows. Gene, chromosome and bp of CpG island are indicated top left.

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

8 WWW.NATURE.COM/NATURECELLBIOLOGY

SV40!

EdU!

SV40!

Supplementary Figure 8!

0!

20!

40!

60!

80!

100!

EdU

pos

itve

cells

(%)!

A! B!

C!

148! DNMT1!250!

D!

148!DNMT1!

250!

148!

98!

64!

DNMT3b!

PD26!

PD34!

PD45!

Sen!

E!

Supplementary Figure 8 SV40-infected “bypass” cells proliferate and uncropped versions of Figures. (A) Bypass cells (SV40) exhibit a low frequency of SA β-gal (<1%). (B) A large proportion of bypass cells (SV40) incorporate a EdU (DNA synthesis) after a 24hr pulse. (C) Quantitation of results from (B),

compared to uninfected PD 22 proliferating cells. Error bars indicate standard deviation. Source data for panel (C) can be found in Supplemental Table 22. (D) Uncropped Figure 3c. (E) Uncropped Supplementary Figure 8a. For (D) and (E), see main figures for loading controls. Scale bar in (A) and (B) = 10mM.

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

WWW.NATURE.COM/NATURECELLBIOLOGY 9

Supplementary Tables Legends

Supplementary Table 1. Sequence yield. Sequence yield is the total number of raw sequence tags produced by the Illumina sequencing technology. Coverage is the product of the number of reads and the number of bases in the read (180 composed of 90 bases per read paired end), divided by the total size of the target genome (hg18 – 3,080,436,051 bases). Aligned reads are the sum of the number of reads that aligned to the hg18 genome. Filtered reads show the number of reads removed due to incomplete bisulfite conversion and potential PCR artifacts. Final reads represents the total number of aligned tags used in downstream analyses passing these filters. Total sequence yield for Proliferating and Senescent samples was 1,748,498,254 reads equaling 314.7Gb of sequence (102.2x coverage total), with a further 750,670,908 reads in cells bypassing senescence; an additional 135Gb of sequence (43.8x coverage total).

Supplementary Table 2. CpG MethylationTotal number of sequenced methylated and unmethylated cytosine bases, in a CpG context, is listed. Me CpG % is the number of methylcytosines divided by the number cytosines (methylated and unmethylated).

Supplementary Table 3. Methylated CpG sitesAt each reference CpG, the binomial distribution was used to identify whether a subset of the fragments within the sample were methylated using a 0.01 FDR corrected p-value. The binomial model was parametized by the error rates obtained in Supplementary Table 7. The numbers of Methylated CpG sites obtained in at least one proliferating/senescent/bypass sample and in at least one sample are also listed. The final figure represents the total number of methylated CpG sites.

Supplementary Table 4. Pearson Correlation CoefficientsEach replicate was pairwise compared with each other replicate using Pearson correlation coefficient. A value of 1 indicates perfect linear correlation while a value of 0 implies no correlation. All comparisons were significant with p ~= 0.

Supplementary Table 5. CHG MethylationThe total number of sequenced methylated and unmethylated cytosine bases, within a CHG context. Me CHG % is the total number of methylcytosines divided by the total number of cytosines (methylated and unmethylated).

Supplementary Table 6. CHH MethylationThe total number of sequenced methylated and unmethylated cytosine bases, within a CHH context. Me CHH % is the total number of methylcytosines divided by the total number of cytosines (methylated and unmethylated).

Supplementary Table 7. Error ratesShown are number of reads, which aligned to the Lambda unmethylated genome, and numbers of methylated and unmethylated cytosines (in any CpG, CHG or CHH contexts). Error rate is a product of sequencing errors and incomplete bisulfite conversion and is computed as the total number of methylated bases sequenced divided by the total number of methylated and unmethylated bases sequenced.

Supplementary Table 8. Individual CpG differencesFor each site in at least one proliferating or senescent sample, obtained in Supplementary Table 3, reads were pooled and a Fisher’s exact test was used to calculate the number of hyper and hypo methylated CpG sites at a FDR corrected P-value level of 0.05.Supplementary Table 9. Expression changes for all genes with a CpG island that are expressed in proliferating cells and show an increase in methylation at the promoter.

Supplementary Table 10. Biofunctions of genes in Supplementary Table 9. Analyzed by Ingenuity Pathway Analysis (IPA). Rank ordered by significance.

Supplementary Table 11. Genes whose promoter methylation increases and expression decreases in senescence. Identified using approach described in Ref. 23.

Supplementary Table 12. Biofunctions of genes in Supplementary Table 11. Analysed by Ingenuity Pathway Analysis (IPA). Rank ordered by significance.

Supplementary Table 13. Overlap of sDMRs, LADs, CpG islands, early and late replicating regions of the genome. Overlap of differentially methylated regions in senescence with Lamin Associated Domains, CpG islands, Early Replicating regions and Late Replicating regions. Overlaps indicate the percent of basepairs overlapping between genomic regions (observed) and the percent of basepairs expected to overlap by chance (expected).

Supplementary Table 14. Overlap of sDMRs with cDMRs described in Ref. 36. Overlap of differentially methylated regions in senescence with differentially methylated regions in cancer as described by Hansen et al. (Ref 36). Overlaps indicate the percent of basepairs overlapping between genomic regions (observed) and the percent of basepairs expected to overlap by chance (expected).

Supplementary Table 15. Overlap of sDMRs with cDMRs described in Ref. 35. Overlap of differentially methylated regions in senescence with differentially methylated regions in cancer as described by Berman et al. (Ref 35). Overlaps indicate the percent of basepairs overlapping between genomic regions (observed) and the percent of basepairs expected to overlap by chance (expected).

Supplementary Table 16. Overlap of sDMRs with cDMRs described in Ref. 3. Overlap of differentially methylated regions in senescence with differentially methylated regions in cancer as described by Hon et al. (Ref 3). Overlaps indicate the percent of basepairs overlapping between genomic regions (observed) and the percent of basepairs expected to overlap by chance (expected).

Supplementary Table 17. Number (no.) of CpGs call classified as methylated and unmethylated in indicated regions (CpG islands) in proliferating cells (P) and senescent cells (S). Bisulphite sequencing data is aggregated for the CpG islands of 8 genes. The number of methylated and unmethylated CpG basecalls in each island is detailed for both proliferating (P) and senescent (S) cells. Fraction proliferating cells (P) and senescent cells (S) is presented where fraction = methylated calls/(methylated calls + unmethylated calls). Absolute methylation differences (S-P) and fold change differences (S/P) are presented along with p-values (fishers exact test). Also shown is the fraction of CpG methylated in bypass cells and P vs bypass comparison as described.

© 2013 Macmillan Publishers Limited. All rights reserved.

S U P P L E M E N TA RY I N F O R M AT I O N

10 WWW.NATURE.COM/NATURECELLBIOLOGY

Supplementary Table 18. Overlap of sDMRs with bypass DMRs. Overlap of differentially methylated regions in senescence with differentially methylated regions in bypass cells. Overlaps indicate the percent of basepairs overlapping between genomic regions (observed) and the percent of basepairs expected to overlap by chance (expected).

Supplementary Table 19. Overlap of sDMR and bypass DMR intersect with cDMRs described in Ref. 36. Differentially methylated regions in senescent and bypass cells were intersected (∩) and the regions in common were overlapped with differentially methylated region in cancer as described by Hansen et al. (Ref 36). Overlaps indicate the percent of basepairs overlapping between genomic regions (observed) and the percent of basepairs expected to overlap by chance (expected).

Supplementary Table 20. Overlap of sDMR and bypass DMR intersect with cDMRs described in Ref. 35. Differentially methylated regions in senescent and bypass cells were intersected (∩) and the regions in common were overlapped with differentially methylated region in cancer as described by Berman et al. (Ref 35). Overlaps indicate the percent of basepairs overlapping between genomic regions (observed) and the percent of basepairs expected to overlap by chance (expected).

Supplementary Table 21. Overlap of sDMR and bypass DMR intersect with cDMRs described in Ref. 3. Differentially methylated regions in senescent and bypass cells were intersected (∩) and the regions in common were overlapped with differentially methylated region in cancer as described by Hon et al. (Ref 3). Overlaps indicate the percent of basepairs overlapping between genomic regions (observed) and the percent of basepairs expected to overlap by chance (expected).

Supplementary Table 22. Statistics source data. For Figures 3a, 3b, 3f, 4d, 3e, 3j, 4g, S8c

Supplementary Table 23. Antibodies and shRNAs used in this study.

© 2013 Macmillan Publishers Limited. All rights reserved.