sem5 word breast pathology

7/29/2019 SEM5 WORD BREAST PATHOLOGY

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Name:Siti Nur Baizury bt Hassan

LOBULAR CARCINOMA

Lobular carcinoma in situ (LCIS)

1. Pathogenesis:Lobular carcinoma in situ (LCIS) is a condition caused by unusual cells in the lobules of the breast.

It is usually not considered cancer, but it can indicate an increased risk of future cancer. Unlike

Ductal Carcinoma in Situ (DCIS), LCIS is not associated with calcification, and is typically an incidental

finding in a biopsy performed for another reason.

Lobular carcinoma in situ (LCIS) is an uncommon condition where benign (non-cancer) change is

seen within the lobules of the breast.

The lobes or lobules are the milk-producing glands that cluster like bunches of grapes at the far end

of the milk ducts in the breast. Under a microscope, normal lobes look empty. When a number of

the lobes appear crowded with cells, the condition is called lobular carcinoma in situ.

Although the term 'carcinoma in situ' can arouse anxiety and thoughts of cancer, LCIS is considered a

benign condition that does not usually require treatment. There are a number of reasons for this.

The multiple cells in the lobes are regular in shape, unlike cancer cells. In addition, the cells are

confined to the lobes ('in situ' means in place). However, long-term follow-up is recommended after

a diagnosis of LCIS.


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2. Gross pictures:

Do not form palpable mass and are often discovered as an incidental finding when a breast

biopsy is performed for other reasons

3. Microscopic pictures:

Lobular carcinoma in situ with complete filling and distortion of the lobular units by tumour

cells Inset: High power view of the lobular cells.

4. Clinical features:LCIS is usually diagnosed before menopause, most often between the ages of 40 and 50.

Less than 10% of women diagnosed with LCIS have already gone through menopause. LCIS is

extremely uncommon in men.

Change in breasts, such as a lump, an area of puckered or otherwise unusual skin, a

thickened region under the skin, or nipple discharge.

5. Complications:LCIS confers increased risk of invasive breast cancer. While older studies have shown that

the increased risk is equal for both breasts, a more recent study suggests that the ipsilateral

(same side) breast may be at greater risk.


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Invasive lobular carcinoma (ILC)

1. PathogenesisInvasive lobular carcinoma begins when cells in one or more milk-producing glands of thebreast develop mutations in their DNA. The mutations tell the cells to divide and grow

rapidly. The cancer cells can spread to other parts of the body.Lobular carcinoma cells tend

to invade surrounding breast tissue in a web-like manner. The affected area may have a

different feel from the surrounding breast tissue, but it is unlikely to feel like a lump.Invasive

lobular carcinoma accounts for 5-10% of invasive breast cancer.Overall, the 5-year survival

rate of invasive lobular carcinoma was approximately 85% in 2003.

2. Gross pictures: Poorly circumscribed and rubbery in consistency

Infiltrating lobular carcinoma presents as solid, firm mass.

Invasive lobular carcinoma


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Infiltrating lobular carcinoma spreads diffusely into the adipose tissue without creating a

visible mass. The only abnormality is firmness by palpation.

3. Microscopic pictures: Composed of strands of tumor cells often one cell in width are looselydispersed in a fibrous stroma(Indian cells).Tumor cells are small and uniform with little

pleomorphism

Invasive lobular carcinoma of the breast demonstrating a predominantly lobular growth

pattern

4. Clinical features:At first, invasive lobular carcinoma may not cause any symptoms. Sometimes, an abnormal area

turns up on a screening mammogram (x-ray of the breast), which leads to further testing. Invasive

lobular carcinomas tend to be more difficult to see on mammograms than invasive ductalcarcinomas are. Thats because instead of forming a lump, the cancer cells more typically spread to


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the surrounding connective tissue (stroma) in a line formation.In other cases, the first sign of ILC is a

thickening or hardening in the breast that can be felt, rather than a distinct lump. Other possible

symptoms include an area of fullness or swelling, a change in the texture of the skin, or the nipple

turning inward.

5. Complications:Cancer in the other breast. Invasive lobular carcinoma is more likely to occur in both breasts

compared with other types of breast cancer. If you're diagnosed with invasive lobular carcinoma in

one breast, your doctor may recommend examination of the other breast to look for signs of cancer.

The lifetime risk of developing cancer in your other breast after a diagnosis of invasive lobular breast

cancer is about 15 percent, which is similar to the risk of developing invasive ductal cancer.

Cancer that spreads to other areas of the body. Invasive lobular carcinoma is slow to spread

(metastasize) beyond the breast, but it can spread to other areas of the body.

REFERENCE

http://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

http://www.riversideonline.com/health_reference/Breast-Cancer/DS00982.cfm

http://www.pathologyoutlines.com/topic/breastmalignantlcis.html

http://www.nature.com/modpathol/journal/v15/n10/full/3880650a.html
http://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situhttp://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situhttp://www.riversideonline.com/health_reference/Breast-Cancer/DS00982.cfmhttp://www.riversideonline.com/health_reference/Breast-Cancer/DS00982.cfmhttp://www.pathologyoutlines.com/topic/breastmalignantlcis.htmlhttp://www.pathologyoutlines.com/topic/breastmalignantlcis.htmlhttp://www.nature.com/modpathol/journal/v15/n10/full/3880650a.htmlhttp://www.nature.com/modpathol/journal/v15/n10/full/3880650a.htmlhttp://www.nature.com/modpathol/journal/v15/n10/full/3880650a.htmlhttp://www.pathologyoutlines.com/topic/breastmalignantlcis.htmlhttp://www.riversideonline.com/health_reference/Breast-Cancer/DS00982.cfmhttp://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

sem5 word breast pathology

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