self-assembly presentation

8/12/2019 Self-Assembly Presentation

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05. 2008 JP Carba al 1

Self Assembly

Definition.Definition.

Characterization. Examples and Applications

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Self Assembly: Definition

Q&A: what is self-assembly.


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Self Assembly: Definition

...refers to aggregation of particles into an organized strctrewithot external assistance!. ". #. Campbell $%%$.

...we limit the term to processes that inole pre-existing com-ponents' are reersible' and can be controlled by the proper design

of the components!. (. ). *hitesides $%%$. ...is the bi+itos process by which ob,ects atonomosly as-

semble into complexes!. C. Aggarwal $%%.

...we limit A to the spontaneos formation of organized strctresfrom many discrete components that interact with one another dir-ectly and/or indirectly throgh their enironment. 0n addition' theassembling components may also be sb,ect to arios global poten-tials sch as externally imposed electromagnetic field or chemicalpotentials!. 1. A. (rzybows2i $%%3.

Answers from the experts


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Self Assembly: Definition Self-assemblyrefers to spontaneos formation of organized

strctres throgh a stochastic process that inoles pre-ex-isting components' are reversible' and can be controlled bythe proper designof the components' the environment' andthe driving force. 0lya 4rigogine 5ideo

Static SA refers to that sbclass of self-assembly processes

that leads to strctres in local or global equilibrium.

Dynamic SArefers to that sbclass of self-assembly processesthat leads to stable non-equilibrium structures. 6hese strc-tres persist only as long as the system is dissipating energy.

4rogrammable Arefers to that sbclass of self-assembly pro-cesses where the componentsof the systemcarry informa-tionabot the final desired structuresor its function.

from: J. A. Pelesko. Self Assembly: The science of things that put themselvestogether. Chapman & Hall C!C. "##$
http://www.youtube.com/watch?v=2NCdpMlYJxQhttp://www.youtube.com/watch?v=2NCdpMlYJxQ


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Self Assembly: Examples

Snow crystals Amphiphilic molecules.Snow crystals Amphiphilic molecules.7staticA. 8yotropic9

(raph (rammar A.

"iffsion-limited aggregation & lmini;s tiles.

4rotein folding & Chain 6ribolon.

)agnetoflids 7dynamic9


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Self Assembly: Examplesnow Crystals

sno%crystals.com


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Self Assembly: Examplesnow Crystals

sno%crystals.com


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Self Assembly: ExamplesAmphiphilic molecles


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05. 2008 JP Carba al

Self Assembly: ExamplesAmphiphilic molecles. 8yotropic li+id crystals

yotropic states


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05. 2008 JP Carba al 10

Self Assembly: !otential Applications

'. (aurer et al. )"##*+.,evelopments in liposomal -rug -elivery systems.

/pert 0pinion on 1iological Therapy2 v. *2 no. 32 pp 4"5647$.

8. P. Torchilin )"##$+. (icellar 'anocarriers: Pharmaceutical Perspectives.Pharmaceutical !esearch2 vol "72 no. *2 pp *6*3.


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05. 2008 JP Carba al 11

Self Assembly

"efinition.

"haracteri#ation."haracteri#ation. Examples and Applications

...to go.


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Self Assembly: "haracteri#ation


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%nits imple or strctred particles.

6he internal strctre' that may be changed by externalstimliis called conformationof the nit.

4assie or actie conformational changes.

Actuation intensity


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&nteraction

'orce field - driven interaction: the energy isprovided by the interaction mechanism itself.Electromagnetic interaction( gravitational interaction(surface tension interaction( ...

&nformation-based interaction: the information is thetrigger of physical)chemical processes( but has norelationship with the energy or energy flows needed by

the latter to unfold. "hemical signals( signal on waves*E+ or mechanical,( electric signals( ...

J. 9. !oe-erer2 ;nformation2 life an- brains2 e-s.2

Astrobiology )?lu%er Aca-2 Publ.2 ,or-recht2 The 'etherlan-s2 "###+2 pp. *$46*47.


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Self Assembly: %nit &nteraction

Cratre arising from a large head grop7A9 and a small head grop 719.

Carbohydrate li+id crystals designed to

show particlar phases. A large head gropexample 7A'C9 and a small head grop case71'"9.

". azio' C. )ongin' 1. "onnio' =. (alerne' ". (illon' and ". *. 1rce #. )ater. Chem >>

%nit shape/ defines structure


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now crystals & Amphiphilic molecles.

0raph 0rammar SA.0raph 0rammar SA.7information-based. 4rogrammable A9


4rotein folding & Chain 6ribolon. )agnetoflids 7dynamic9


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Self Assembly: Examples(raph (rammar A

. ?lavins )"##$+. Programmable self6assembly.

; control systems vol. "$2 no 72 pp. 5 6@3


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et of rles' transitions.


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Environment

;sign mo-el applet

tatic or dynamic enironments

4roides a way to control the system.

J. 1ishop2 . ?lavins )"##3+. Collective Sensing %ith Self60rganiing !obots.Proc. 7@th ; Conf. on ,ecision & Control.
http://www2.truman.edu/~velasco/ising.htmlhttp://www2.truman.edu/~velasco/ising.html


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(raph (rammar A.

Diffusion-limited aggregation 'lumini1s tiles.Diffusion-limited aggregation 'lumini1s tiles.7Enironment' external fields. 4assie conformational switches9

4rotein folding & Chain 6ribolon.

)agnetoflids 7dynamic9


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Self Assembly: Examples *2eminder,


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Self Assembly: Examples"8A

,A moviehttp:%%%.an-ylomas.com

Clster grown from a copper slfatesoltion in an electrodeposition cell.

imlated ?" "8A with external fields.
http://home/juanpi/Teaching/AL08/Self-Assembly/aggregation_movie_003.movhttp://home/juanpi/Teaching/AL08/Self-Assembly/aggregation_movie_003.mov


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Self Assembly: Exampleslmini;s tiles

Shaking table movie


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Self Assembly: Exampleslmini;s tiles

Can we obtain thephase diagram@

*hat are theparameters tostdy@


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Driving 'orces Cold be indced by the interaction.

0ndependent of the system to aoid clamping.

natural -ynamics
http://home/juanpi/Teaching/AL08/Self-Assembly/out.avihttp://home/juanpi/Teaching/AL08/Self-Assembly/out.avi


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$hermodynamic 3ypothesis

Stochastic assembly

4roposed in relation to protein folding: A protein as-smes a particlar conformation becase that stateis thermodynamically the most faorable. 6he con-formation is a global minimmof the free energy of

the system. 6he protein samples the energy space'eentally winding p at a global minimm.andomconformational search

Critics ...
http://home/juanpi/Teaching/AL08/Self-Assembly/stochastic.wmvhttp://home/juanpi/Teaching/AL08/Self-Assembly/stochastic.wmv


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'olding !athway 3ypothesis 6ime needed to explore the possibilities

is astronomical' 8einthal paradox!.6he folding se+ence is predefined! inthe dynamics of strctre.

'olding 'unnel 3ypothesis 6he energy minimm is extremely deep and

with steep walls.

C. evinthal )*43B+. Are there path%ays for protein fol-ingD.

J. Chimie Phys. Phys.6Chimie 1iol. 3@: 7767@


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'olding 'unnel 3ypothesis"onformational entropyis the entropy associated with the geometrical

arrangement of a chain of nits. 6he concept is most commonly ap-plied to biological macromolecles sch as proteins and BA. 6o cal-clate the conformational entropy' the possible conformations as-smed by the chain may be discretized into a finite nmber of states'

sally characterized by ni+e combinations of certain strctralparameters' each of which has been assigned an energy leel. 6heconformational entropy associated with a particlar conformation isthen dependent on the probabilityassociated with the system ta2ingthat state' as determined by the sm of the energiesassociated withthe parameters describing the state.


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(raph (rammar A.


!rotein folding "hain $ribolon.!rotein folding "hain $ribolon.7search space9 )agnetoflids 7dynamic9


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4rotein olding A gien amino acid ta2es on roghly the same roteand pro-

ceeds throgh roghly the same intermediates and transitionstates.

Alpha helices and beta sheets then tertiary strctre. orma-

tion of +aternary strctre sally inoles the assembly ofsbnits that hae already folded.

6he amino acid se+enceof each protein contains the inform-ationthat specifies both the natie strctre and the pathwayto attain that state.

Conformations differ based on enironmental factors.


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05. 2008 JP Carba al 32


Chain 6ribolonConformational entropy

... 4 565


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erroflids

?. 1utter et al. )"##5+. ,irect observation of -ipolar chains in iron ferroflui-s by cryogenic

electron microscopy. 'ature (aterials no. "2 pp BB 6 4*.

=erroflui- -emostration
http://www.youtube.com/watch?v=A5OhZ9wT568http://www.youtube.com/watch?v=A5OhZ9wT568


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05. 2008 JP Carba al 35

Self Assembly: !otential Applications

elf-repair /self-healing: econstrction of s2in from a

sspension of s2in cells from a >-day embryonic mose.

(onroy2 A. an- A. A. (oscona. ;ntro-uctory Concepts in ,evelopmental 1iology.Eniversity of Chicago Press2 Chicago. *4$4.

)A+ intact embryonic skin

)1+ tF#

)C+ tF"7 hr

),+ (igration

)+ tF$" hr

self6healing robot
http://www.youtube.com/watch?v=uIn-sMq8-Lshttp://www.youtube.com/watch?v=uIn-sMq8-Ls


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05. 2008 JP Carba al 36

Self Assembly: ...to go

nctionality

ow to endow or engineered systems with fnc-tionality@

6heory *hat are the nderlying principles of A@

Can we generalize to different scales@


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Self Assembly: 7uestions8

the end...the end...??

self-assembly presentation

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