sector landscapes: research tools

SECTORLANDSCAPES

Leading the conversation.

RESEARCH TOOLS2015

About LifeScience Alley

LifeScience Alley is a global leader in enabling health technology and care organizations to innovate, succeed and influence the evolution of healthcare. By influencing policy, delivering actionable information and intelligence and connecting members with critical resources, we work to ensure that Minnesota's Medical Alley remains the world's strongest health technology community.

SECTOR LANDSCAPES: RESEARCH TOOLSCopyright © 2015 by LifeScience Alley. All rights reserved.

About Sector Landscapes PublicationsThe Sector Landscapes provide in depth analysis of emerging and established industry sectors in Minnesota. The reports highlight global industry insights, Minnesota core and supporting assets, unique positioning, company lists, and industry trends. Identified sector areas include: neuromodulation, cardiac active implantables, tissue based products, research tools, animal health, diagnostics, vascular technologies, and digital health.

List of Contributors

PLEASE DIRECT CORRESPONDENCE TO:

Cheryl Matter, PhD, Vice President of Research & Intelligence, LifeScience [email protected] | 952.746.3817

Emily Tubman, Market Analyst, LifeScience AlleyUniversity of Minnesota Biomedical Engineering PhD CandidatePrimary Researcher & Author

Bridget Wall, PhD, LifeScience Alley ConsultantSecondary Researcher & Author

Amanda K. Weber, Design & Research Associate, LifeScience AlleyResearch Visualization & Design

LifeScience Alley's intelligence and research work is generously supported by our Foundational and Sustaining Members.

Foundational Members

Sustaining Members

The Research Tools sector in Minnesota is composed of 27 companies distributed among the following fields, with the largest proportion in the cell biology space.

+ Cell Biology (13) + Instrumentation (4) + Materials / Chemistry (3) + Supporting (7)

The sector is bolstered by the success of R&D Systems, a mature Minneapolis-based research tools company that started in the 1970’s. However there are a number of emerging, innovative companies that started in the 2000s.The University of Minnesota, the Mayo Clinic, and the technical workforce generated by the existing medical device and engineering industries provide an excellent talent pool of potential employees and development partners. Lastly, incubators that provide affordable wet lab and office space, as well as tax credits for R&D and angel investors, promote growth and investment in this burgeoning industry.

EXECUTIVE SUMMARY

five companies

ten companies

fifteen companies

1971

1999

1915-2015

MINNESOTA RESEARCH TOOLS INDUSTRY GROWTH OVER 100 YEARS

[1] NATIONAL CONTEXT OF AVAILABLE RESEARCH TOOLS 1

The US is the world leader in the Research Tools sector, with revenues from the top seven companies reaching nearly $50 billion in 2014.

US RESEARCH TOOLS COMPANIES 2

[2] MINNESOTA RESEARCH TOOLS COMPANIES 5

Minnesota has twenty-seven Research Tools companies and has been growing drastically since the early 2000s.

MINNESOTA INDUSTRY 6

DEFINITIONS OF RESEARCH TOOLS COMPANIES BY CATEGORY 6

SPOTLIGHT ON R&D SYSTEMS 8

SPOTLIGHT ON EMERGING RESEARCH TOOLS COMPANIES 9

[3] INSIDE THE MINNESOTA RESEARCH TOOLS SECTOR 11

The diversity of technical expertise, concentration of incubators and new tax incentives have encouraged a robust start-up economy in Minnesota.

STATE & REGIONAL CLUSTERS OF RESEARCH TOOLS 14

TECHNICAL EXPERTISE 15

SUPPORTING INFRASTRUCTURE 18

INCUBATORS 20

TAX INCENTIVES 21

[4] MINNESOTA RESEARCH TOOLS DIRECTORY 23

LIST OF FIGURES

FIGURE 1. The Top Seven Research Tools Companies in the US 2

FIGURE 2. Map of Minnesota Research Tools by Category 7

FIGURE 3. Timeline History of R&D Systems 8

FIGURE 4. Minnesota Research Tools Company Breakdown 12

FIGURE 5. Minnesota Company Clusters 14

FIGURE 6. NIH Awards & Funding + "IBRC" Corridor 16

FIGURE 7. Minnesota's Biology to Engineering Spectrum 19

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NATIONAL CONTEXT OF RESEARCH TOOLS

1.

2 Sector Landscapes: Research Tools | LifeScience Alley

Research tools companies develop products that facilitate life science research. Examples of products include cell biology products and instrumentation, analytical testing equipment and laboratory parts. The US is the world leader in research tools companies, with revenues from the top seven companies reaching nearly $50 billion in 2014. Although none of the nation’s largest research tools companies are headquartered in Minnesota, Thermo Fisher Scientific’s Product Inspection Division is located in Coon Rapids, MN, and Beckman Coulter's Immunoassay Division is located in Chaska, MN.

"Map of United States of America with States - Outline by FreeVectorMaps.com" (page 2 and 16).

FIGURE 1. THE TOP SEVEN RESEARCH TOOLS COMPANIES IN THE US

3Section 1 | National Context of Available Research Tools

THE TOP SEVEN

COMPANY HEADQUARTERS REVENUE EMPLOYEES

Thermo FisherScientific 1

Waltham, MA(MN operations) $17 Billion

5000 (~120 in MN)

Becton Dickinson 2

Franklin Lakes, NJ $8.4 Billion 3000

Beckman Coulter(Danaher Corp) 3

Brea, CA(MN operations) $6.9 Billion

24000(~1000 in MN)

Agilent Technologies 4 Santa Clara, CA $7.0 Billion 21400

VWR 5 Randor, PA $4.2 Billion 8400

Sigma Aldrich(subsidiary of Merck) 6

St. Louis, MO $2.7 Billion 9000

BioRad 7 Hercules, CA $2.1 Billion 7750

1 SOURCE: Thermo Fisher Scientific. http://wwwthermofisher.com/en/about-us.html2 SOURCE: Becton Dickinson. (2014). Annual Report 2014. Retrieved from http://bd.com/ar2014/

3 SOURCE: Danaher. (2013). Annual Report 2013. Retrieved from http://media.corporate-ir.net/media_files/IROL/82/82105/Danaher_2013_Annual _Report.pdf

4 SOURCE: Agilent. (2014). Annual Report 2014. Retrieved from http://www.investor.agilent.com/5 SOURCE: VWR. (2013). Form 10-K 2013. Retrieved from http://investor.vwr.com/secfiling

6 SOURCE: Sigma Aldrich. (2013). Annual Report 2013. Retrieved from http://files.shareholder.com/down-loads/SIGMA

7 SOURCE: Biorad. (2013). Annual Report 2013. Retrieved from http://www.bio-rad.com/webroot/web/pdf/corporate/literature/Bio-Rad_2013AnnualReport.pdf

1

2

3

4

5

6

7

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MINNESOTA RESEARCH TOOLS COMPANIES

2.


The Research Tools sector in Minnesota is small but growing, with a total of 27 companies occupying the space. Growth of research tools com-panies started in the 1970s and expanded in the 2000s, with cell biology tools companies, instrumentation companies, materials and chemistry companies and other companies that support research technology.1

R&D Systems, Biovest International and Lifecore Biomedical are Minnesota’s only large, public research tools companies. Other public companies that develop products that support research technology are the Donaldson Company, ATMI / Entegris and Protolabs. The majority of the research tools companies are emerging, private and small, with at least ten of the companies having 100 or fewer employees, suggesting that this is an area of growth in the life sciences.

1 See Research Tools Directory (p 21).

DEFINITIONS OF RESEARCH TOOLS COMPANIES BY CATEGORY

Cell Biology Tools Companies

Stem cells, proteins, peptides, reagents, assays and kits

Instrumentation Companies

Fluorescence plate readers and array tape

Materials / Chemistry Companies

Medical device coatings and specialty chemicals

Supporting Companies

Filter media, bioreactors, metallic and rubber parts, valves and tubing

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FIGURE 2. MAP OF MINNESOTA RESEARCH TOOLS BY CATEGORY

INSTRUMENTATION (4 COMPANIES)

CELL BIOLOGY (13 COMPANIES)

SUPPORTING (7 COMPANIES)

MATERIALS / CHEMISTRY (3 COMPANIES)


SPOTLIGHT ON R&D SYSTEMS

R&D (Research and Diagnostics) Systems was founded in Minneapolis in 1976 and became a public company in 1984. It is one of three major brands of Bio-Techne, which had sales of more than $350

million in 2014. The small company that started in Minneapolis now has branches in Germany, England and China; combined with Bio-Techne’s other brands, they have more than 24,000 products with 95% of them manufactured in-house.1,2 Bio-Techne’s main product lines include immunoassays, antibodies and kits. Today, the company employs more than 650 Minnesotans.

R&D Systems was the first cell biology company in what has been a growing industry in Minnesota. It paved the way for companies such as Kingfisher Biotech, Neuromics and ImmunoChemistry Technologies, employing some of these companies’ founders. “Many companies share the common history or link of R&D Systems, not only biotech companies, but even medical device companies" says Joanna LaBresh, President of Kingfisher Biotech.

1 SOURCE: Techne Corporation (2014). Form 10-K 2014. Retrieved from https://www.sec.gov/2 SOURCE: R&D Systems. http://www.rndsystems.com/about_us.aspx

FIGURE 3. TIMELINE HISTORY OF R&D SYSTEMS

2015

2005

1995

1985

1975

Implemented new brand, Bio-Techne

Acquired six new companies

Released first research reagent, TGF-beta 1Acquired by Techne Corporation

Released whole blood control with platelets

Sold first hematology control

Established R&D Systems EuropeAcquired Amgen and Genzyme research businesses

Formed Growth Factor Division

$50 M

$190 M

$357 M

9Section 2 | Minnesota Research Tools Companies

1 SOURCE: Douglas Scientific. http://www.douglasscientific.com/2 SOURCE: Fluorescence Innovations, Inc. http://www.fluorescenceinnovations.com/

3 SOURCE: Innovative Surface Technologies. http://www.isurtec.com/4 SOURCE: National Institutes of Health RePorter (2014). http://report.nih.gov/award/index.cfm

SPOTLIGHT ON EMERGING RESEARCH TOOLS COMPANIES

Minnesota has a number of early-stage research tools companies founded in the early 2000s. Among the most innovative are Douglas Scientific, Fluorescence Innovations, Inc. and ISurTec.1,2,3 In 2014, Fluorescence Innovations, Inc. received more than $180,000 from the National Institutes of Health and from 2011 to 2013, ISurTec received more than $2,000,000 in Small Business Innovative Research (SBIR) grants.3,4

Fluorescence Innovations, Inc. has developed instrumentation that utilizes their proprietary Direct Waveform Recording Technology™ to measure

the lifetime fluorescence decay, which significantly reduces noise and improves fluorescence measurements. It was founded in 2006 in Bozeman, MT, and has since moved to a new location in Minneapolis, MN.

Innovative Surface Technologies (ISurTec) developed a temperature-responsive cell growth surface for the gentle, non-invasive release of cells from cultureware and microcarriers, which

eliminates the need for trypsin or other harsh reagents. ISurTec was founded in 2004 and is located in St. Paul, MN.

ImmunoChemistry Technologies (ICT) provides high quality research reagents and laboratory services. ICT supplies in vitro apoptosis assays,

caspase kits, fluorescent reagents for intracellular analysis and other critical detection tools to help biomedical researchers understand metabolic pathways and cure disease. ICT also offers a line of ELISA development solutions including coat buffers, conjugate stabilizers and sample diluents. As a CRO, ICT specializes in custom immunoassay development, conjugation, lyophilization and consulting services.

With operations in 17 countries worldwide, Douglas Scientific is a fast-growing laboratory automation company based in Alexandria, Minnesota (two hours northwest of the Twin Cities). Their novel Array Tape® technology has radically increased throughput of PCR reactions while simultaneously decreasing reaction volume and overall experiment cost. Their ultra-high throughput solution, Nexar®, was first utilized by agriculture companies to perform SNP genotyping on plant samples. They reinvested profits in research and development, and have adapted their technology into two smaller-scale instruments.The IntelliQube® is the first fully automated system that integrates liquid handling, thermal cycling, detection and analysis into one instrument. It too is optimized for Array Tape and is used for both end-point and quantitative PCR applications. The other is the AmpliFire®, a point-of-use, hand held instrument that leverages isothermal chemistry to facilitate sample to answer responses in minutes. It is easily employed out in the field to test plant, animal, food and for research use in diagnostics of human samples for diseases. Most notably, the AmpliFire contributed to the global effort to address the ebola virus.

Douglas Scientific currently has 115 employees mostly based in Alexandria and a satellite office in Hopkins, MN. As demand for the Array Tape Platform continues to grow and revolutionize labs, Douglas Scientific is expanding operations in the US and international markets specially focusing on India, China and Brazil.

INSIDE THE MINNESOTA RESEARCH TOOLS SECTOR

3.


CELL BIOLOGYAncell [1]

BRTI Life Sciences [2]Imanis Life Sciences [3]

Immuno Biologic Lab. [4]ImmunoChemistry Tech. [5]

Kingfisher Biotech [6]Lifecore Medical [7]

Microbiologics [8]Mill Creek Life Sciences [9]

Neuromics [10]R&D Systems [11]

Surrogen [12]Verge Bio [13]

SUPPORTINGDagan Corporation [1]

Donaldson Company [2]ATMI / Entegris [3]

Gamma Vacuum [4]Inclined Biomedical Tech. LLC [5]

Protolabs [6]Test Resources [7]

13Section 3 | Inside the Minnesota Research Tools Sector

INSTRUMENTATION[1] Biovest [2] Fluorescence Innovations, Inc.[3] Douglas Scientific[4] iLAB LLC

MATERIALS / CHEMISTRY[1] Harland Medical[2] ISurTec[3] LKT Labs

FIGURE 4. MINNESOTA RESEARCH TOOLS COMPANY BREAKDOWN


The majority of Minnesota research tools companies reside in the Twin Cities Metro. However, there are a handful of companies in other regions in the state, including southwest of the Twin Cities (Gibbon, Shakopee and Waconia), Rochester, Bayport, Alexandria and St. Cloud (Figure 5).

Minnesota is also part of what Greg Gillispie, President of Fluorescence Innovations, Inc. calls the Inland Biomedical Research Corridor (IBRC) that runs from the Twin Cities to Pittsburgh. Using the NIH RePORTER Tool, he compared different geographical regions in 2011 and 2012 and discovered that the top institutions in the IBRC have more funding than those in California.

Gillispie moved his company from Bozeman, Montana to Minneapolis in 2012 to capitalize on the opportunities in the region.

"The top 12 [institutions in the IBRC] have greater National Institutes of Health funding cumulatively than the top 12 institutions in California!"

Gregory Gillispie, President of Fluorescence Innovations, Inc.

STATE AND REGIONAL CLUSTERS OF RESEARCH TOOLS

FIGURE 5. MINNESOTA COMPANY CLUSTERS

1 COMPANY

2 COMPANIES

3 COMPANIES

17 COMPANIES


TECHNICAL EXPERTISE

Minnesota is home to one of the largest medical device clusters in the world, with companies such as Medtronic, St. Jude Medical, Boston Scientific and 3M either headquartered in Minnesota or with significant operations in the state.

The University of Minnesota (UMN) is a major research institution with campuses in the Twin Cities, Crookston, Duluth, Morris and Rochester. Together, UMN-Twin Cities and UMN-Duluth

received more than $300 million in federal funding from the National Institutes of Health and the National Science Foundation in 2014. The College of Biological Sciences (CBS) and the College of Science and Engineering (CSE), both on the Twin Cities campus, have 129 CBS and 430 CSE tenure and tenure-track faculty, and 2693 CSE and 313 CBS graduate students.1,2 These colleges contributed to the accolades the University recently received when it was named the 29th “Best Global University” by US News and World Report in 2014.3 Besides providing a technical workforce, the University also houses many facilities that provide access to equipment useful to research tools companies.4

“The advantage here is the concentration of medical device companies. There really isn’t a better place to be from that perspective.”

Eric Guire, Senior Scientist at Innovative Surface Technologies

1 SOURCE: The University of Minnesota College of Biological Sciences. http://www.cbs.umn. edu/explore/about/cbs-glance

2 SOURCE: The University of Minnesota College of Science and Engineering. http://cse.umn. edu/aboutcse/CSE_CONTENT_192612.php

3 SOURCE: US News and World Report. http://www.usnews.com/education/best-global-univer sities/rankings?page=3

4 See Research Tools Directory (p 21).

16 Sector Landscapes: Tissue & Biologics | LifeScience Alley

AWDS FUNDING

AL 593 $273,600,407

AK 17 $10,793,647

AZ 404 $158,598,561

AR 104 $46,767,479

CA 7731 $3,499,391,307

CO 922 $313,993,551

CT 1122 $467,188,982

DE 67 $38,759,337

D.C. 380 $194,613,257

FL 1104 $476,217,118

GA 1161 $482,742,805

HI 86 $47,415,169

ID 17 $10,687,130

IL 1885 $733,227,259

IN 589 $210,731,457

IA 411 $169,772,206

KS 238 $109,462,489

KY 386 $153,050,665

LA 278 $140,203,878

ME 113 $72,949,821

MD 2296 $1,333,845,959

MA 4924 $2,404,091,828

MI 1423 $577,502,620

MN 1050 $504,952,618

MS 79 $43,166,617

MO 1073 $490,212,280

MT 67 $36,014,739

NE 218 $88,610,327

NV 45 $25,543,601

NH 203 $96,944,063

NJ 547 $246,964,069

NM 217 $96,781,115

NY 4808 $2,125,150,125

NC 2192 $1,067,282,781

ND 29 $15,893,123

OH 1564 $670,092,509

OK 174 $88,105,625

OR 673 $303,963,471

PA 3377 $1,516,874,603

P.R. 84 $42,352,575

RI 439 $132,043,025

SC 422 $147,391,886

SD 36 $21,577,280

TN 1076 $466,225,823

TX 2527 $981,024,135

UT 459 $175,427,096

VT 108 $58,132,718

V.I. 3 $1,760,298

VA 770 $327,737,296

WA 1585 $906,173,368

WV 42 $18,958,353

WI 883 $386,436,340

WY 18 $7,485,353

FIGURE 6. NIH 2014 AWARDS & FUNDING 1 + "IBRC" CORRIDOR

1 SOURCE: http://www.report.nih.gov/award/index.cfm


“The media still does not accept Minnesota as a place for cell culture companies. We are constantly asked why we are here. When we tell them we are in Rochester, then it makes sense.”

Judy Lundy, President and COO, Mill Creek Life Sciences

The Mayo Clinic, with locations in Rochester, MN, Scottsdale and Phoenix, AZ, and Jacksonville, FL, received the highest honor by US News and World Report when it was named “Best Hospital in 2014/2015.” The Mayo Clinic, Rochester received more than $203 million in funding from the National Institutes of Health

in 2014 and the entire clinic has an annual research budget of more than $625 million.1,2 The Mayo Clinic has more than 200 investigators in seven academic research areas. Imanis Life Sciences, located in Rochester, MN, was founded and is currently run by Mayo Clinic professors.

When asked about the workforce in Minnesota, every company president and CEO interviewed emphatically stated that it is a strength of the region. Therefore, it is not surprising that companies (both big and small) in Minnesota span the range from cell and molecular biology to mechanical engineering, making it an ideal location for research tools companies seeking a highly-skilled technical workforce.

1 SOURCE: The National Institutes of Health RePorter (2014). 2 SOURCE: The Mayo Clinic. http://www.mayo.edu/mgs/programs/faculty

SUPPORTING INFRASTRUCTURE


Neuromics

R&D Systems

ImmunochemistryTechnologies

Biovest

Surrogen

Beckman Coulter

Harland Medical

Douglas Scientific

Medtronic

St. Jude Medical

Boston Scientific

Sciencix

Kingfisher Biotech

Apogen Biotechnologies

ImmunobiologicLaboratories

3M

ISurTec

North Central InstrumentsFluorescence Innovations, Inc.

Protolabs

Test Resources

Applied Vacuum Technology

CELL & MOLECULAR

BIOLOGY

PROTEOMICS

& GENOMICS

MATERIALS

SCIENCE

MECHANICAL

ENGINEERING

BIOMEDICAL

ENGINEERING

FIGURE 7. MINNESOTA'S BIOLOGY TO ENGINEERING SPECTRUM


INCUBATORS

Incubators encourage early-stage companies by providing wet-labs and office space at affordable prices, and by hosting events to bring together the life science community. The two most prominent are University Enterprise Laboratories (UEL) and the Mayo Clinic Business Accelerator, which house multiple life science companies. Both ISurTec and Kingfisher Biotech are located in UEL, where tenants individually applied for and received more than $45 million in new investments and research grants in 2013.1

1 See Research Tools Directory (p 21).2 SOURCE: Leightner, Amanda. June 2015. "MN Business Incubators and Accelerators." Life Science Nexus. Retrieved August 2015. 3 SOURCE: www.mcbusaccel.com. Retrieved August 2015.4 SOURCE: www.mnwesttechnology.com. Retrieved August 2015.5 SOURCE: www.theseedpartners.com. Retrieved August 2015.6 SOURCE: www.uelmn.org. Retrieved August 2015.

University Enterprise LaboratoriesUniversity Enterprise Laboratories (UEL) is a life science incubator in St. Paul, MN, with a focus on biotech, medtech and special university departments. More than 30 companies have been tenants since its opening in 2005.2,6

Worthington Biotechnology Advancement CenterThe Worthington Biotechnology Advancement Center is an incubator located in Worthington, MN, with a focus on agribusiness and animal health companies.2

The SEED PartnersThe SEED Partners is a newly opened biosciences incubator, accelerator and investor in the North Loop. Their 27,000 square foot space includes a 5,000 square foot wet lab facility, including fume hoods, cell culture space, and other basic & specialized life science equipment. In addition to providing shared lab and collaborative work spaces, SEED can assist clients from the early stages of an idea to product concept, as well as provide business support, office support and laboratory support services.5

Mayo Clinic Business AcceleratorBased in Rochester, MN, the Mayo Clinic Business Accelerator opened in 2013 with a focus on medtech and healthtech. As of August 2015, there have been a total of 20 company tenants.3

MinnWest Technology Campus2006 marked the founding of the MinnWest Technology Campus in Willmar, MN, a biobusiness incubator focusing on agribusiness and biotechnology. More than 30 companies currently reside as tenants (2015).2,4

Business Enterprise CenterThe Business Enterprise Center (BEC) is an accelerator located in Cottage Grove, MN. It offers affordable work space and support services to startups.2


TAX INCENTIVES

To encourage innovation in the state and investment in startup companies, the State of Minnesota has implemented the R&D Tax Credit and the Angel Tax Credit.

R&D Tax CreditEligible recipients receive a 10% credit on qualifying expenses up to $2 million, and 2.5% for expenses surpassing that amount.1

Angel Tax CreditRewards investors 25% for investing in startups focusing on new and innovative technology.2

"The biggest advantage (of conducting my business) in Minnesota is the Angel Tax Credit. For small start-ups, this is HUGE!"

Judy Lundy, President and COO, Mill Creek Life Sciences

1 SOURCE: Minnesota Revenue. http://www.revenue.state.mn.us/2 SOURCE: Minnesota DEED. http://mn.gov/deed/

IN CONCLUSION,

The Research Tools sector in Minnesota is small but growing. R&D Systems, the oldest, largest and most established tools company, has paved the way for cell biology companies. Additionally, a number of companies exist that support research tools companies, such as engineering companies that develop manufactured parts. Today, there are a number of innovative companies developing tools and instrumentation to facilitate research.

Minnesota’s strong biomedical industry, academic institutions and a world-class clinic have provided training for generations of scientists and engineers that make up Minnesota’s technical workforce. Minnesota is committed to building and keeping innovative companies in-state, demonstrating its commitment by implementing programs to support research and development and early-stage venture.

With its solid infrastructure in the biosciences and engineering, programming to encourage investment in early-stage companies and recent emergence of small, private tools companies, the Research Tools sector in Minnesota is poised for growth in the upcoming decades.

CONTRIBUTORS

Thank you to the company presidents, CEOs, and others who generously contributed their time and shared their perspectives on the industry: Chris Echeverri, Greg Gillispie, Eric Guire, Patrick Guire, Joanna LaBresh, Judy Lundy and Donna Pinotti.

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MINNESOTARESEARCH TOOLS DIRECTORY

4.



Company City, State Founded Summary

Ancell Bayport, MN 1992 Produce immunology research tools.

ATMI / Entegris Bloomington, MN 1966 Provides products and materials used in high-technology manufacturing.

Biovest International, Inc. Minneapolis, MN 1983 Protein manufacturing instruments utilizing proprietary hollow fiber technology.

BRTI Life Sciences Two Harbors, MN 2003 3D- cell culture tool & matrix that creates a microenvironment for multiple applications.

Douglas Scientific Alexandria, MN 2009 Designs and manufactures laboratory instrumentation.

Dagan Corporation Minneapolis, MN 1974 Produces scientific instruments including voltage and cell patch clamps.

Donaldson Company Bloomington, MN 1915 Filtration manufacturer.

Fluorescence Innovations, Inc. Minneapolis, MN 2006 Instrumentation that measures fluorescence

lifetime properties of biological systems.

Gamma Vacuum LLC Shakopee, MN 2003 Ion pumps, titanium sublimation pumps, non-evaporable getters and their controls.

Harland Medical Eden Prairie, MN 2003 Product solutions for healthcare surface enhancement market.

iLAB LLC Maple Grove, MN - Design and development of biomedical instrumentation.

Imanis Life Sciences Rochester, MN 2012 Non-invasive reporter systems - cell lines, lentivirus and contract imaging solutions.

Immuno BiologicalLaboratories Minneapolis, MN 1997 Clinical laboratory reagent assays for

research and clinical testing.

ImmunoChemistry Technologies Bloomington, MN 1994 Protein chemistry lab. Apoptosis assays and

ELISA detection reagents.

25Section 4 | Minnesota Research Tools Directory



Inclined Biomedical Technologies LLC Minneapolis, MN - Develops lab tools for academia, med /

pharma, hospitals and government facilities.

Innovative Surface Technologies (ISurTec) St. Paul, MN 2004 CRO; develops scaffolds and matrices, drug

delivery and surface coatings.

Kingfisher Biotech St. Paul, MN 2008 Research reagents for variety of species.

Lifecore Biomedical LLC Chaska, MN 1986Manufactures Hyaluronan and other biomaterials for various medical applications.

LKT Labs St. Paul, MN 1988 Specialty chemicals for cancer chemoprevention.

Microbiologics St. Cloud, MN 1971 Ready-to-use high quality lyophilized micro-organisms.

Mill Creek Life Sciences Rochester, MN 2010 Products to supplement cell culture used in stem / primary cells.

Neuromics Edina, MN 2003 Reagents and methods for Neuroscience Research Community.

Protolabs Maple Plain, MN 1999 Plastic injection molding parts.

R&D Systems Minneapolis, MN 1985 Produces human cytokines for genetic engineering.

Surrogen, Inc. St. Paul, MN 2013 Genetically-tailored large animal models of disease.

Test Resources Shakopee, MN 1998 Materials testing equipment.

Verge Bio Minneapolis, MN 2014 Designs and engineers diagnostic cell-permeant tracers and dyes.


UNIVERSITY OF MINNESOTA FACILITIES

UMN Facility Director Summary

Characterization Facility Greg [email protected]

Materials research spanning from nanotechnology to biology and medicine.

Magnetic Transport Laboratory

Dan [email protected]

Applications and advancement of Magnetic Force Microscopy (MFM).

Tissue Mechanics Laboratory

Robert [email protected]

Specialized instruments for soft biological materials.

Supercomputing Institute Jorge Viñ[email protected]

Provides access to high-performance computing resources.

Nano Center Steve [email protected]

Small-scale devices, nano materials and bio-medical applications of nanotech.

NMR Center Gianluigi [email protected]

Research and education in implementation of NMR techniques to biomedical research.

Imaging Center Mark [email protected]

Advanced optical imaging and basic electron microscopy.

MINNESOTA INCUBATORS


Business Enterprise Center Cottage Grove, MN - Work space and supportive services.

MinnWest Technology Campus LLC Willmar, MN 2006 Biobusiness incubator focusing on

agribusiness and biotechnology.

Mayo Clinic Business Accelerator Rochester, MN 2013 Collaborative space for new companies,

venture capital firms and entrepreneurs.

The SEED Partners Minneapolis, MN - Collaboration between business professionals & entrepreneurs in life science tech & medtech.

University Enterprise Laboratories St. Paul, MN 2001 Collaborative research center, advancing

biology and biotechnology.

Worthington Biotechnology Advancement Center Worthington, MN - Focus on agribusiness & animal health

companies.

[email protected]

[email protected]

[email protected]

[email protected]

[email protected]

[email protected]

sector landscapes: research tools

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