section ii: kinetics and bioreactor design lesson 10...bioreactor design aims for today’s lesson...
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![Page 1: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/1.jpg)
SECTION II: KINETICS AND BIOREACTOR DESIGN:
LESSON 10.1. - Bioreactor design – Design Equations
JAVIER CALZADA FUNES
Biotechnology Department, Biosciences School
UNIVERSIDAD FRANCISCO DE VITORIA
![Page 2: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/2.jpg)
BIOREACTOR DESIGN
AIMS FOR TODAY’S LESSON
10.1 Design equations
10.2 Exercises
10.3 Tank vs Tubular reactor: Comparing efficiency
10.4 Recycle, By-pass and Purge
10.5 Bioreactor association
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Introduction Continuous Tank Reactor Tubular Reactor Ideal Batch Reactor
BIOREACTOR DESIGN
• Asenjo, J.A. y Merchuck, J.C. (1994), Bioreactor System Design. Marcel
Dekker. 1-12.
• Atkinson, B. (2002), Reactores Bioquímicos, Reverté (Barcelona).
• Bailey, J.E., Ollis D.F. (1986), Biochemical Engineering Fundamentals,
McGraw-Hill (Nueva York).
• Doran, P.M. (2013), Bioprocess Engineering Principles, Academic Press
(Londres).
REFERENCES:
![Page 4: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/4.jpg)
BIOREACTOR DESIGN
1.- IDEAL BATCH REACTOR
2.- IDEAL CONTINUOUS TANK REACTOR
3.- TUBULAR REACTOR
![Page 5: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/5.jpg)
BIOREACTOR DESIGN
1.- IDEAL BATCH REACTOR
![Page 6: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/6.jpg)
Introduction Ideal Batch Reactor
BIOREACTOR DESIGN
Tubular Reactor Continuous Tank Reactor
1. IDEAL BATCH REACTOR
No entrance nor exit.
Complete Mix is supposed constant composition
everywhere within the reactor.
Accumulation Inputs Outputs Generation - + =
Ri V
Ci
Accumulation 0 0 Generation - + =
Accumulation Generation =
![Page 7: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/7.jpg)
Introduction Ideal Batch Reactor
BIOREACTOR DESIGN
Tubular Reactor Continuous Tank Reactor
1. IDEAL BATCH REACTOR
RA V
CA
Accumulation Generation =
dt
dNVR A
A ·
Accumulated
amount of "A”
Moles of "A“
disappearing in
a certain time =
For “A” reagent:
![Page 8: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/8.jpg)
Introduction Ideal Batch Reactor
BIOREACTOR DESIGN
Tubular Reactor Continuous Tank Reactor
1. IDEAL BATCH REACTOR
A
A
A
A
C
C A
A
C
C A
A
t
A
A
A
A
AA
R
dCt
R
dCdt
R
dCdt
VR
dNdt
dt
dNVR
000
·
·RA V
CA
For “A” reagent:
![Page 9: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/9.jpg)
Introduction Ideal Batch Reactor
BIOREACTOR DESIGN
Tubular Reactor Continuous Tank Reactor
1. IDEAL BATCH REACTOR
For “A” reagent
“A” conversion
RA V
CA
0
0
A
AAA
N
NNX
AA X
A
AA
X
A
AA
t
A
AA
A
AA
AAA
AA
A
AAA
A
AAA
R
dXCt
R
dXCdt
R
dXCdt
VR
dXNdt
dt
dXNVR
dt
dXN
dt
dN
XNNN
NNX
0
0
0
0
0
00
00
0
0
0
·
·;
1
![Page 10: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/10.jpg)
Introduction Ideal Batch Reactor
BIOREACTOR DESIGN
Tubular Reactor Continuous Tank Reactor
1. IDEAL BATCH REACTOR
RA V
CA
Accumulation Generation =
dt
dNVR A
A ·
DESIGN EQUATION
A
A
A C
C A
A
X
A
AA
R
dC
R
dXCt
00
0
![Page 11: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/11.jpg)
Introduction Ideal Batch Reactor
BIOREACTOR DESIGN
Tubular Reactor Continuous Tank Reactor
1. IDEAL BATCH REACTOR
RA V
CA rR
Akr
oductsA
A
·
Pr
DESIGN EQUATION – EASIEST CASE
FIRST ORDER reaction
AA
A
XAkR
AkR
1··
·
0
![Page 12: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/12.jpg)
Introduction Ideal Batch Reactor
BIOREACTOR DESIGN
Tubular Reactor Continuous Tank Reactor
1. IDEAL BATCH REACTOR
RA V
CA
DESIGN EQUATION – EASIEST CASE
FIRST ORDER reaction
AA CkR ·
A
A
C
C A
A
C
C A
A
C
C
kt
C
dC
kCk
dCt
A
A
A
A
0·ln1
·1
·00
![Page 13: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/13.jpg)
Introduction Ideal Batch Reactor
BIOREACTOR DESIGN
Tubular Reactor Continuous Tank Reactor
1. IDEAL BATCH REACTOR
RA V
CA
DESIGN EQUATION – EASIEST CASE
FIRST ORDER reaction
AAA XCkR 1·· 0
A
X
A
A
X
A
A
X
AA
AA
XkX
dX
kt
Xk
dX
XCk
dXCt
A
AA
1
1·ln
1
1·
1
1·1··
0
00 0
0
![Page 14: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/14.jpg)
BIOREACTOR DESIGN
1.- IDEAL BATCH REACTOR
2.- IDEAL CONTINUOUS TANK REACTOR
3.- TUBULAR REACTOR
![Page 15: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/15.jpg)
BIOREACTOR DESIGN
2.- IDEAL CONTINUOUS TANK REACTOR
![Page 16: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/16.jpg)
Continuous Tank Reactor
BIOREACTOR DESIGN
Introduction Tubular Reactor Ideal Batch Reactor
2. IDEAL CONTINUOUS REACTOR
Uniform entrance and exit F0 = F1
Complete Mix is supposed constant composition
everywhere within the reactor.
Steady State, constant volume no accumulation
Accumulation Inputs Outputs Generation - + =
Fo, Co F1, C1
Ri V
C1
![Page 17: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/17.jpg)
Continuous Tank Reactor
BIOREACTOR DESIGN
Introduction Tubular Reactor Ideal Batch Reactor
2. IDEAL CONTINUOUS REACTOR
0··· 0 VRCFCF AAA
For “A” reagent
Q, CA0 Q, CA
RA V
CA
0 Inputs Outputs Generation - + =
Accumulation = 0
![Page 18: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/18.jpg)
Continuous Tank Reactor
BIOREACTOR DESIGN
Introduction Tubular Reactor Ideal Batch Reactor
2. IDEAL CONTINUOUS REACTOR
A
AA
AAA
AAA
R
CC
F
V
VRCCF
VRCFCF
0
0
0
··
0···
For “A” reagent
DESIGN EQUATION
Residence time = V/F
F, CA0 F, CA
RA V
CA
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Continuous Tank Reactor
BIOREACTOR DESIGN
Introduction Tubular Reactor Ideal Batch Reactor
2. IDEAL CONTINUOUS REACTOR
A
AA
AAA
AAAA
R
XC
F
V
VRXCF
VRXCFCF
0
0
00
··
0·1···
For “A” reagent
DESIGN EQUATION
Residence time = V/F
F, CA0 F, CA
RA V
CA
![Page 20: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/20.jpg)
BIOREACTOR DESIGN
1.- IDEAL BATCH REACTOR
2.- IDEAL CONTINUOUS TANK REACTOR
3.- TUBULAR REACTOR
![Page 21: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/21.jpg)
BIOREACTOR DESIGN
3.- TUBULAR REACTOR
![Page 22: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/22.jpg)
Tubular Reactor
BIOREACTOR DESIGN
Introduction Ideal Batch Reactor Continuous Tank Reactor
3. TUBULAR REACTOR
Uniform entrance and exit F0 = F1
Plug Flow is supposed no element of fluid is mixed with
another one entering before or after it.
Steady State, constant volume no accumulation
Accumulation Inputs Outputs Generation - + =
F, Co F, C1 F, C F, C+dC
dV
![Page 23: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/23.jpg)
Tubular Reactor
BIOREACTOR DESIGN
Introduction Ideal Batch Reactor Continuous Tank Reactor
3. TUBULAR REACTOR
dVRdCF
dVRdCF
dVRdCCFCF
AA
AA
AAAA
··
0··
0···
0 =
F, Co F, C1 F, C F, C+dC
dV
Inputs Outputs Generation - +
![Page 24: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/24.jpg)
Tubular Reactor
BIOREACTOR DESIGN
Introduction Ideal Batch Reactor Continuous Tank Reactor
3. TUBULAR REACTOR
F, Co F, C1 F, C F, C+dC
dV
F
V
R
dC
F
dV
R
dC
F
dV
R
dCdVRdCF
A
A
A
A
C
C A
A
VC
C A
A
A
AAA
00
··
·0··
0
![Page 25: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/25.jpg)
Tubular Reactor
BIOREACTOR DESIGN
Introduction Ideal Batch Reactor Continuous Tank Reactor
3. TUBULAR REACTOR
F, Co F, C1 F, C F, C+dC
dV
dVRdXFC
dVRdXFC
dVRXCdF
dVRdCF
AAA
AAA
AAA
AA
···
0···
0·1··
0··
0
0
0
![Page 26: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/26.jpg)
Tubular Reactor
BIOREACTOR DESIGN
Introduction Ideal Batch Reactor Continuous Tank Reactor
3. TUBULAR REACTOR
F, Co F, C1 F, C F, C+dC
dV
F
V
R
dXC
F
dV
R
dXC
F
dV
R
dXC
dVRdXFC
A
A
X
A
AA
VX
A
AA
A
AA
AAA
0
0
00
00
0 ···
![Page 27: SECTION II: KINETICS AND BIOREACTOR DESIGN Lesson 10...BIOREACTOR DESIGN AIMS FOR TODAY’S LESSON 10.1 Design equations 10.2 Exercises 10.3 Tank vs Tubular reactor: Comparing efficiency](https://reader033.vdocuments.site/reader033/viewer/2022051509/5ad5a0b47f8b9a5c638d4fcf/html5/thumbnails/27.jpg)
BIOREACTOR DESIGN
ANY QUESTION?
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SECTION II: KINETICS AND BIOREACTOR DESIGN:
LESSON 10.1. - Bioreactor design – Design Equations
JAVIER CALZADA FUNES
Biotechnology Department, Biosciences School
UNIVERSIDAD FRANCISCO DE VITORIA