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Sponsored by

David C. Koch RegionalPerfusion Cancer Therapy Center

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University of Pittsburgh School of Medicine

Center for Continuing Educationin the Health Sciences

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UPMC Cancer Centers

Course Co-Directors

H. Richard Alexander, MDProfessor of SurgeryUniversity of Maryland Medical CenterBaltimore, Maryland

David L. Bartlett, MDProfessor of SurgeryUniversity of Pittsburgh School of MedicinePittsburgh, Pennsylvania

Robert P. Edwards, MDVisiting Professor, Obstetrics, Gynecology and

Reproductive SciencesUniversity of Pittsburgh School of MedicinePittsburgh, Pennsylvania

Second International Symposium on

Regional Cancer TherapiesCourtyard by Marriott ~ Isla Verde

San Juan, Puerto Rico

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1

Intent and Overview

This course is designed to cover the most recent advances in cancertherapy that are primarily of a regional focus, such as gastrointestinal,intraperitoneal, hepatic, ovarian and thoracic. Upon completion of theactivity, learners from several disciplines should be able to discuss thelatest regional therapies in surgical oncology and describe how theseadvances can be applied to their practice.

Who Should Attend

This course is designed for physicians and nurses practicing inthe areas of Medical, Surgical, Thoracic and Gynecologic Oncologyand Gastroenterology.

Continuing Education Credit

The University of Pittsburgh School of Medicine is accredited by theAccreditation Council for Continuing Medical Education to providecontinuing medical education for physicians.

The University of Pittsburgh School of Medicine designates thiseducational activity for a maximum of 19.5 AMA PRA Category 1 Credits™.Each physician should claim only those credits that he/she actuallyspent in the educational activity.

Other health care professionals are awarded 1.95 continuing educationunits (CEU’s) which are equal to 19.5 contact hours.

3

Schedule - Sunday, February 25 , 2007

Moderators: John Kane III, MD and Rodney Landreneau, MD

7:00 am Breakfast

7:30 am Minimally Invasive Platform for Regional Lung TherapeuticsTodd Demmy, MD, et al.

7:45 am Long-Term Outcome in Patients with Malignant MelanomaTreated with ILP +/- TNFJoseph Blansfield, MD, et al.

8:00 am Patterns of Recurrence and Survival Following SurgicalResection and Intraoperative Photodynamic Therapy (PDT) forNon-Small Cell Lung Cancer (NSCLC)Joseph Friedberg, MD, et al.

8:15 am Advanced Extremity Soft Tissue Sarcoma: Prognostic EffectAlessandro Gronchi, MD, et al.

8:30 am Limited Cardiotoxicity After Intrathoracic Chemotherapy withDoxorubicin and CisplatinEelco de Bree, MD, et al.

8:45 am Basic Science of HyperthermiaRoger Vertrees, PhD, et al.

9:00 am Novel and Existing Mutations in the Tyrosine Kinase Domain ofthe EGFR ReceptorJason Foster, MD, et al.

9:15 am Systemic vs. Regional Therapy for Peritoneal Carcinomatosisfrom Colon CancerPaul Mansfield, MD

10:00 am Break with Refreshments

10:15 am Pleural PerfusionSebastien Gilbert, MD

11:00 am Why Does HIPEC Fail?Paul Sugarbaker, MD

11:45 am Abstract Poster Session and Buffet LunchModerator: David Bartlett, MD

1:30 pm Morning Session Adjournment

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Schedule - S AT U R DAY, F E B RUA RY 24, 2007

6:45 am Registration and Breakfast

7:25 am Welcome: David Bartlett, MD

Moderators: Brian Loggie, MD and John Stewart IV, MD

7:30 am Isolated Chemotherapy – Perfusion of PelvisHoward Wanebo, MD, et al.

7:45 am Multimodality Treatment of Peritoneal Surface Malignancies –First Results of a German Referral CentrePompiliu Piso, MD, et al.

8:00 am Survival Analysis for 101 Patients with MalignantPeritoneal Mesothelioma (MPM)Richard Royal, MD, et al.

8:15 am Expanding the Indications of Cytoreductive Surgery andHyperthermic Intra-Peritoneal ChemotherapyDario Baratti, MD, et al.

8:30 am Unresolved Issues in IP TherapyMaurie Markman, MD

9:15 am Aggressive Cytoreduction Surgery for Ovarian CancerDennis Chi, MD

10:00 am Break with Refreshments

10:15 am Updates on Randomized Trials for IP TherapyDeborah Armstrong, MD

11:00 am Application of Anti-Adhesive Materials to Enhance IP TherapyKristin Zorn, MD

11:45 am Case Presentations and Discussion:Peritoneal CarcinomatosisRobert Edwards, MD and Edward Levine, MD

12:30 pm Adjournment for Morning Session

5:00 pm Optional Event – Workshop/VideoTechniques in IP Therapy: Dwell & IPHCH. Richard Alexander, MD and C. William Helm, MB, BChir

7:00 pm Evening Session Adjournment

schedule continued on next page

54

5:00 pm Optional Event – WorkshopEstablishing a Regional Therapy ProgramJesus Esquivel, MD and John Kane III, MD

6:00 pm Optional Event – WorkshopThe Operating Room of the FutureJames Luketich, MD

8:00 pm Evening Session Adjournment

Schedule - M O N DAY, F E B RUA RY 26, 2007

Moderators: Matthew Holtzman, MD and James F. Pingpank Jr., MD

7:00 am Breakfast

7:30 am Percutaneous Liver Perfusion for Patients with MetastaticNeuroendocrine TumorsWilliam Burns, MD, et al.

7:45 am Hepatic Arterial Oxaliplatin in Combination with SystemicIntravenous Fluorouracil, Leucovorin and BevacizumabLuis Camacho, MD, et al.

8:00 am Hepatic Artery Directed Yttrium (SIR-Spheres) for UnresectableColorectal Liver TumorsT. Clark Gamblin, MD, et al.

8:15 am Phase I Trial Results for Liver Perfusion with OxaliplatinHerbert Zeh III, MD, et al.

8:30 am The Expanding Role of Y-90 Resin Microsphere Selective InternalRadiation TreatmentRichard Hostetter, MD, et al.

8:45 am Therapeutic Response to Transcatheter Arterial Embolization(TACE) of the LiverAvo Artinyan, MD, et al.

9:00 am Decrease Local Recurrences with Intraoperative Radiotherapyfor Rectal CancerKaryn Stitzenberg, MD

9:15 am Total Body Hyperthermia for the Treatment of Patients withHepatitis C Virus Unresponsive to Other Therapies: A Pilot StudyFrancesco Izzo, MD, et al.

9:30 am Modified Technique for Isolated Hepatic PerfusionRoberto Verzaro, MD, et al.

9:45 am Break with Refreshments

10:00 am Regional Therapy of the LiverYuman Fong, MD

10:45 am Lessons Learned – U.S. Experience with Limb PerfusionDouglas Fraker, MD

11:30 am Case Presentations and Discussion:LiverH. Richard Alexander, MD, David Bartlett, MD and Yuman Fong, MD

1:30 pm Conference Adjournment and Final Remarks

The University of Pittsburgh, as an educational institution and as an employer, values equality of opportu-

nity, human dignity, and racial/ethnic and cultural diversity. Accordingly, the University prohibits and will

not engage in discrimination or harassment on the basis of race, color, religion, national origin, ancestry,

sex, age, marital status, familial status, sexual orientation, disability, or status as a disabled veteran or a

veteran of the Vietnam era. Further, the University will continue to take affirmative steps to support and

advance these values consistent with the University’s mission. This policy applies to admissions, employ-

ment, access to and treatment in University programs and activities. This is a commitment made by the

University and is in accordance with federal, state, and/or local laws and regulations. For information on

University equal opportunity and affirmative action programs and complaint/grievance procedures, please

contact: William A. Savage, Assistant to the Chancellor and Director of Affirmative Action (and Title IX

and 504 Coordinator), Office of Affirmative Action, 901 William Pitt Union, University of Pittsburgh,

Pittsburgh, PA 15260, (412) 648-7860.

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Jesus Esquivel, MDSt. Agnes HospitalBaltimore, Maryland

Yuman Fong, MDProfessor of SurgeryCornell UniversityNew York, New York

Jason Foster, MDAssistant Professor of SurgeryCreighton University Medical SchoolOmaha, Nebraska

Douglas L. Fraker, MDAssociate Professor of SurgeryUniversity of Pennsylvania

Health SystemPhiladelphia, Pennsylvania

Joseph Friedberg, MDAssociate Professor of SurgeryUniversity of Pennsylvania

Health SystemPhiladelphia, Pennsylvania

T. Clark Gamblin, MDAssistant Professor of Surgery

Sebastien Gilbert, MDAssistant Professor of Surgery

Alessandro Gronchi, MDMilan Tumor InstituteMilan, Italy

C. William Helm, MB, BChirAssociate Professor of Obstetrics

and GynecologyUniversity of Louisville

School of MedicineLouisville, Kentucky

Matthew Holtzman, MDAssistant Professor of Surgery

Richard B. Hostetter, MDAssistant Professor of SurgeryIndiana UniversityGoshen, Indiana

Francesco Izzo, MDNational Institute for the

Study and Cure of TumorsNaples, Italy

John M. Kane III, MDAssistant Professor of SurgeryUniversity at BuffaloBuffalo, New York

Rodney Landreneau, MDProfessor of Surgery

Edward A. Levine, MDProfessor of SurgeryWake Forest UniversityWinston-Salem, North Carolina

Brian W. Loggie, MDProfessor of SurgeryCreighton University Medical SchoolOmaha, Nebraska

James D. Luketich, MDSampson Family Endowed

Professor of SurgeryChief, Division of Thoracic and

Foregut Surgery

Paul Mansfield, MDProfessor of SurgeryUniversity of TexasHouston, Texas

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Deborah K. Armstrong, MDAssociate Professor of Oncology Associate Professor of Gynecology

and Obstetrics Johns Hopkins UniversityBaltimore, Maryland

Avo Artinyan, MDCity of Hope National Medical CenterDuarte, California

Dario Baratti, MDMilan Tumor InstituteMilan, Italy

Joseph Blansfield, MDBethesda, Maryland

William Burns, MDBethesda, Maryland

Luis H. Camacho, MDAssistant Professor of SurgeryUniversity of TexasHouston, Texas

Dennis Chi, MDProfessor of SurgeryCornell UniversityNew York, New York

Eelco de Bree, MDAssistant Professor of SurgeryUniversity of Crete Medical School Crete, Greece

Todd L. Demmy, MDAssociate Professor of Surgery University at BuffaloBuffalo, NY

Course Co-Directors and Faculty are affiliated with the University of PittsburghSchool of Medicine, Pittsburgh, Pennsylvania, unless noted otherwise.

Course Co-Directors

H. Richard Alexander, MDProfessor of Surgery

University of Maryland

David L. Bartlett, MDProfessor of Surgery

University of Pittsburgh School of Medicine

Robert P. Edwards, MDVisiting Professor, Obstetrics, Gynecology and Reproductive Sciences

University of Pittsburgh School of Medicine

Faculty

9

Meeting Location

The conference will be held at the Courtyard by Marriott – Isla Verde,7012 Boca de Cangrejos Avenue, Carolina, Puerto Rico, 00979. Conferencereservations are the sole responsibility of the attendees who may contactthe Courtyard by Marriott reservations at: 1-800-791-2553 or directly at:(787) 791-0404. A three (3) night minimum is required. Attendees are requiredto identify themselves as participating in the University of Pittsburgh CancerConference in February so that they may take advantage of the group rate. Onspace available basis, the group rate will be available for 3 days pre and postconference for guests who wish to arrive early or stay late. The deadline forreduced-rate reservations is 1/24/07.

Nightly Guest Room Rates (Single/Double)Standard Room $205.00One Bedroom Suite $355.00

Note: Hotel’s room rates are subject to applicable 10% resort fee plus 11%government tax. The room rates are based on double occupancy. Additionalthird/fourth persons will pay a $25.00 fee. Children 12 and under may stayfree in the same room with parents.

Air Transportation Options

San Juan Airport (SJU) is approximately one mile (ten minutes’ drive) from theCourtyard by Marriott – Isla Verde. Taxis are plentiful at the airport curbsidewith $10.00 fare to Courtyard by Marriott. Various national car rental optionsare available at the airport or by advanced booking.

Special Needs

Participation by all individuals is encouraged. Advance notification of anyspecial needs will help us provide better service. Please notify us of yourneeds at least two weeks in advance of the program by callingRebecca J. Beward at (412) 623-5993.

�

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Maurie Markman, MDProfessor of Gynecologic and

Medical OncologyUniversity of TexasHouston, Texas

James F. Pingpank Jr., MDBethesda, Maryland

Pompiliu Piso, MDProfessor of SurgeryUniversity of RegensburgRegensburg, Germany

Richard Royal, MDBethesda, Maryland

John Stewart IV, MDInstructor of SurgeryWake Forest UniversityWinston-Salem, North Carolina

Karyn Stitzenberg, MDUniversity of North CarolinaChapel Hill, North Carolina

Paul H. Sugarbaker, MDWashington Hospital CenterWashington, DC

Roger Vertrees, PhDAssistant ProfessorUniversity of TexasGalveston, Texas

Robert Verzaro, MDMediterranean Institute for

Transplantation and AdvancedSpecialized Therapies (ISMETT)

Palermo, Italy

Harold J. Wanebo, MDRoger Williams Medical CenterProvidence, Rhode Island

Herbert Zeh III, MDAssistant Professor of Surgery

Kristin Zorn, MDAssistant Professor, Obstetrics,

Gynecology and ReproductiveSciences

In accordance with Accreditation Council for Continuing Medical Education requirements

on disclosure, information about relationships of presenters with commercial interests (if

any) will be included in materials distributed at the time of the conference.

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The UPMC/Center for Continuing Education in the Health Sciences reservesthe right to cancel this program if sufficient registrations are not received.In the case of cancellation, the department will fully refund registration fees.However, other costs incurred by the registrant, such as airline or hotel penalties,are the responsibility of the registrant.

Registration Fees $250 Physicians and Researchers$200 Nurses and other health care professionals$100 Other

Registration fee includes:• Continuing education credit• Registration and course materials • Continental breakfast, refreshments and Sunday lunch

For additional information, contact:Rebecca J. BewardTelephone: (412) 623-5993Fax: (412) 692-2520Email: bewardbj@upmc.edu

Visit the Center for Continuing Educationin the Health Sciences Web Site

Our Internet address is: http://ccehs.upmc.eduThe UPMC/Center for Continuing Education in the Health Sciences invites youto visit our web location. Receive information on CME programs, earn CMEcredits on the Internet, and access information about our formal courses andmuch more. Discover who we are and how you can contact us. Please visit ourweb location often to get updated information on upcoming programs.

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Registration Information

PRE-REGISTER – All pre-registrations are due two weeks prior to the begindate of the conference. Registrations after this date are accepted onlyas on-site registrations.

> On-line Registration

On-line Registration accepted until February 10, 2007.

Registering online is the quickest and easiest way to reserve your space atCCEHS conferences.

Visit our online registration site at http://ccehs.upmc.edu

Scroll to the Second International Symposium on Regional Cancer Therapiessection on the web page

Click the Registration button and enter all the requested information

After registering, an electronic confirmation will be sent to the email addressyou provided us when you registered.

> On-site Registration

As of February 11, 2007 all registrations for this course are acceptedonly as on-site registrations.

Please note: Registration is not complete until you receive the confirmationletter / email for your pre-registration. If you do not receive this letterwithin 5-7 days of registration, please contact us at (412) 647-8232.

You must bring this confirmation with you to the conference.

Registration CancellationAll cancellations must be in writing and sent to us via U.S. mail, e-mail or fax.Tuition for cancellations postmarked or date stamped before January 15, 2007will be completely refunded. After January 15, 2007, a $35 administrative feewill be assessed. No refunds will be made after February 1, 2007.

Conference contact for cancellation requests:Rebecca J. Beward, MBA/MHACancer Pavilion 412, 5150 Centre Avenue, Pittsburgh, PA 15232Telephone: (412) 623-5993Fax: (412) 692-2520Email: bewardbj@upmc.edu