search algorithm allows for a collection of posterior ... · 10/29/2018  · beast - bayesian...

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Page 1: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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Page 2: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

Search algorithm allows for a collection of posterior trees that can be both used in subsequent analyses and help interpret the phylogenetic result

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Page 3: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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Page 4: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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Page 5: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

Sampling through time. E.g. Tracing the spread of Salmonella resistance

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Page 6: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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Page 7: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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Page 8: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

Careful not to treat it like a black box.

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Page 9: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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Page 10: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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Page 11: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

Model testing can be done within Beast (path sampling).

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Page 12: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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Page 13: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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Page 14: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

Broom vs bush trees

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Page 15: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

Really need some sort of hard bound on a node: many studies will use a maximum

age of the group

C volcanic emergence : uniform prior with hard upper limit : equal prob after the

event.

F fossil: lognormal: most of distribution around the age of the fossil but a tail that lets

the node age be older.

J1-4: breakup (beginning and late) of land: normal broad priors around the age that is

known

M2-2:opening up of a straight: exponential

We are

going to set M = 1:78 and S = 0:085 which will specify a distribution centred

at about 6 million years with a standard deviation of about 0.5 million years.

This will give a central 95% probability range covering 5-7 Mya.

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Page 16: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

Yule: birth only (probably only reasonable for closely related organisms) BD: includes extinction in the model

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Page 17: Search algorithm allows for a collection of posterior ... · 10/29/2018  · BEAST - Bayesian phylogenetic analysis using molecular sequences Data, Models of evolution, Priors + Likelihood

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