Improving the patient's life through medical educationwww.excemed.org

EXCEMED - Excellence in Medical EducationRepresentative OfficeSalita di San Nicola da Tolentino 1/B 00187 Rome, Italy.T +39.06.420.413, F +39.06.420.413.677

HeadquartersEXCEMED14, Rue du Rhone, 1204 Geneva, Switzerland

Copyright © EXCEMED, 2014. All rights reserved.

Generalinformation

AccreditationThe Italian National Commission for Continuing Medical Education hasaccredited this SIF SRL event n. 1841- 105289 (provider reference number- event reference number),“1st International Meeting of Diabetes andBone” (7-8 November, 2014, Rome, Italy) for N. 8 (eight) Italian CME credits.

This programme has been designed in partnership with the UniversitàCampus Bio-Medico di Roma (UCBM).

This programme is endorsed by SID (Società Italiana di Diabetologia), SIE(Società Italiana di Endocrinologia) and SIOMMMS (Società Italiana dell’Osteoporosi del Metabolismo Minerale e delle Malattie dello Scheletro).

PresidentsSol EpsteinMt. Sinai School of Medicine New York, NY, USA

Paolo Pozzilli University Campus Bio-Medico di Roma (UCBM)Rome, Italy

Scientific organisersSol Epstein Mt. Sinai School of Medicine New York, NY, USA

Nicola Napoli University Campus Bio-Medico di Roma (UCBM)Washington UniversityRome, Italy

VenueHotel ColumbusVia della Conciliazione, 33 - 00193 Roma, ItalyPhone: +39 06 686 5435

LanguageThe official language of this live educational workshop will be English.Simultaneous translation is provided from English to Italian and vice versa.

Organising secretariatEXCEMED - Excellence in Medical Education Salita San Nicola da Tolentino, 1/B - 00187 - Rome, ItalyProgramme Manager: Giovanna Rossi - info@excemed.org

Scientific SecretariatSocietà di Formazione Internazionale SRL Scientific Provider No. 1841

All EXCEMED programmes are organized solely to promote the exchangeand dissemination of scientific and medical information. No forms ofpromotional activities are permitted. This programme is made possiblethanks to educational grants received from:

Platinum grantor

Gold grantor

Silver grantor

Bronze grantor

1st International meetingof diabetes and bone

Background and AimDiabetes is one of the fasting growing diseases in the western world andis becoming a huge problem in emerging economic power houses suchas India and Asia and particularly China. The number of patients isstaggering and the rate of newly diagnosed diabetics continues to grow.This is especially as Type 2 diabetes mellitus (DMT2) is associated withobesity which in itself is becoming a global health problem.Osteoporosis is another disease increasing due to aging populations andan accompanying increase in fractures. There are approximately 1.5million fractures per year in the USA .The population suffering low bonedensity is about 44 million, of which about 14 million are osteoporotic. Thecost of the disease has been estimated to be in the region of $22 billionannually. The mortality after a hip fracture is around 50 % in the first year.Rising morbidity is accompanied by loss of independence. Despite effectivedrugs reducing the fracture burden by about 50-60% the disease is stillnot recognized, diagnosed, or treated.

Learning objectivesBy attending this live educational meeting the learners will be able to:• Assess fracture risk in diabetic patients•Utilise the latest pathophysiology of bone fragility in diabetes•Utilise the latest diagnostic tools and treatment options for diabetesrelated fractures

Target audienceEndocrinologists, Diabetologists, Rheumatologists, Internal medicine andprimary care physicians.

Faculty members

Bo AbrahamsenInstitute of Clinical Research, SDUResearch Centre for Ageingand Osteoporosis, Department of Medicine M,Glostrup Hospital (Nord)Glostrup, Denmark

Laurie BaggioMt. Sinai HospitalSamuel Lunenfeld Research InstituteToronto, Ontario, Canada

Marco BaroniClinica MedicaUniversity of Rome “La Sapienza”Rome, Italy

Dennis BlackUniversity of CaliforniaSan Francisco (UCSF)San Francisco, California, USA

Henry BoneMichigan Bone and Mineral Clinic PCUniversity of MichiganDetroit, USA

Iacopo ChiodiniOspedale Maggiore Policlinico IRCCS Milan, Italy

Roberto CivitelliDivision of Bone and Mineral DiseasesMusculoskeletal Research CenterWashington University School of MedicineSt. Louis, Missouri, USA

Renate T. de JonghVU Medical CenterAmsterdam, The Netherlands

David DempsterCollege of Physicians and Surgeonsof Columbia UniversityRegional Bone Cente,Helen Hayes HospitalNew York State Department of HealthNew York, USA

Rivka Dresner-PollakHadassah-Hebrew University Medical Center Jerusalem, Israel

Sol EpsteinMt. Sinai School of Medicine New York, NY, USA

Paolo FalaschiUniversity of “La Sapienza”Rome, Italy

Luigi GennariUniversity of Siena“Santa Maria alle Scotte” HospitalSiena, Italy

Andrea GiustinaUniversity of BresciaBrescia, Italy

Didier HansUniversity of LausanneLausanne, Switzerland

Giancarlo IsaiaUnit of Geriatrics and Metabolic BoneDiseases. Molinette HospitalAO Città della Salute e della Scienzadi Torino School of Geriatric MedicineUniversity of Torino Italian Osteoporosis and Metabolic BoneDiseases Society (SIOMMMS)Torino, Italy

Davide LauroUniversity of “Tor Vergata”Rome, Italy

Andrea LenziUniveristy of “La Sapienza”Rome, Italy

Laura McCabeBiomedical Imaging Research CenterMichigan State UniversityEast Lansing, MI, USA

Silvia Migliaccio"Foro Italico" Universi tyRome, Italy

Geltrude MingronePoliclinico GemelliUniversità Cattolica del Sacro CuoreRome, Italy

Nicola Napoli University Campus Bio-Medico di Roma(UCBM)Rome, Italy

Paolo PozzilliUniversity Campus Bio-Medico di Roma(UCBM)Rome, Italy

Ann SchwartzUniversity of CaliforniaSan Francisco (UCSF)San Francisco, California, USA

17.30 L11 Design of clinical trials to evaluate skeletal benefit and risk in diabetic patientsH. Bone (USA)

18.00 Clinical round table and open debateH. Bone (USA), I. Chiodini (Italy), S. Epstein (USA)P. Falaschi (Italy), N. Napoli (Italy), A. Schwartz (USA)

18.30 End of the first day

Saturday, 8 November 2014

Chairpersons: D.Lauro (Italy), S. Migliaccio (Italy)

09.00 L12 Animal models of diabetic bone disease.Advantages and disadvantagesL. McCabe (USA)

09.30 L13 Latest advances in technology to assess diabeticbone diseaseD. Hans (Switzerland)

10.00 L14 Bone histomorphometry and bone MarkersD. Dempster (USA)

10.30 Coffee Break

Chairpersons: D. Dempster (USA), L. Gennari (Italy)

11.00 L15 Post transplant bone disease in diabeticsS. Epstein (USA)

11.30 L16 The role of the anti-aging gene Sirtuin1 in Diabetes and OsteoporosisR. Dresner-Pollak (Israel)

Lilly symposium - Not CME accredited

12.00 L17 Does Anabolic therapy have a role in the treatmentof diabetic bone diseaseN. Napoli (Italy)

12.30 Concluding remarks

13.00 End of the Meeting

Scientific programme

Friday, 7 November 201410.00 Registration

10.45 Welcome and introductionS. Epstein (USA), N. Napoli (Italy), P. Pozzilli (Italy)

Chairpersons: S. Epstein (USA), G. Isaia (Italy)

11.00 L1 New concepts and latest research directionsin the pathophysiology of diabetes P. Pozzilli (Italy)

11.30 L2 Osteoblasts in diabetic patients, too lazy or just insulin resistant?R. Civitelli (USA)

12.00 L3 The obesity epidemic, and the central role of adipose tissue in metabolic disordersM. Baroni (Italy)

12.30 L4 Diabetes and fractures. Is it a global health problem?B. Abrahamsen (Denmark)

13.00 Lunch

Chairpersons: B. Abrahamsen (Denmark), A. Giustina (Italy)

14.00 L5 Neuro endocrine, GUT hormones and BoneL. Baggio (Canada)

14.30 L6 Prevention of diabetes through bariatric surgeryG. Mingrone (Italy)

15.00 L7 Vitamin D and diabetesR. de Jongh (The Netherlands)

15.30 L8 Pathophysiology of diabetic bone diseaseA. Schwartz (USA)

16.00 Coffee Break

Chairpersons: I. Chiodini (Italy), A. Schwartz (USA)

16.30 L9 Incretin based treatments or old fashion medications,from diabetes treatment to bone healthN. Napoli (Italy)

17.00 L10 Implications for the treatment of osteoporosisin the diabetic patientN. Napoli (Italy)

Scientific programme

Session I

Session V

Session II

Session III The treatment of bone fragility in diabetic patients

Session IV

1st International meetingof diabetes and bone

Background and AimDiabetes is one of the fasting growing diseases in the western world andis becoming a huge problem in emerging economic power houses suchas India and Asia and particularly China. The number of patients isstaggering and the rate of newly diagnosed diabetics continues to grow.This is especially as Type 2 diabetes mellitus (DMT2) is associated withobesity which in itself is becoming a global health problem.Osteoporosis is another disease increasing due to aging populations andan accompanying increase in fractures. There are approximately 1.5million fractures per year in the USA .The population suffering low bonedensity is about 44 million, of which about 14 million are osteoporotic. Thecost of the disease has been estimated to be in the region of $22 billionannually. The mortality after a hip fracture is around 50 % in the first year.Rising morbidity is accompanied by loss of independence. Despite effectivedrugs reducing the fracture burden by about 50-60% the disease is stillnot recognized, diagnosed, or treated.

Learning objectivesBy attending this live educational meeting the learners will be able to:• Assess fracture risk in diabetic patients•Utilise the latest pathophysiology of bone fragility in diabetes•Utilise the latest diagnostic tools and treatment options for diabetesrelated fractures

Target audienceEndocrinologists, Diabetologists, Rheumatologists, Internal medicine andprimary care physicians.

Faculty members

Bo AbrahamsenInstitute of Clinical Research, SDUResearch Centre for Ageingand Osteoporosis, Department of Medicine M,Glostrup Hospital (Nord)Glostrup, Denmark

Laurie BaggioMt. Sinai HospitalSamuel Lunenfeld Research InstituteToronto, Ontario, Canada

Marco BaroniClinica MedicaUniversity of Rome “La Sapienza”Rome, Italy

Dennis BlackUniversity of CaliforniaSan Francisco (UCSF)San Francisco, California, USA

Henry BoneMichigan Bone and Mineral Clinic PCUniversity of MichiganDetroit, USA

Iacopo ChiodiniOspedale Maggiore Policlinico IRCCS Milan, Italy

Roberto CivitelliDivision of Bone and Mineral DiseasesMusculoskeletal Research CenterWashington University School of MedicineSt. Louis, Missouri, USA

Renate T. de JonghVU Medical CenterAmsterdam, The Netherlands

David DempsterCollege of Physicians and Surgeonsof Columbia UniversityRegional Bone Cente,Helen Hayes HospitalNew York State Department of HealthNew York, USA

Rivka Dresner-PollakHadassah-Hebrew University Medical Center Jerusalem, Israel

Sol EpsteinMt. Sinai School of Medicine New York, NY, USA

Paolo FalaschiUniversity of “La Sapienza”Rome, Italy

Luigi GennariUniversity of Siena“Santa Maria alle Scotte” HospitalSiena, Italy

Andrea GiustinaUniversity of BresciaBrescia, Italy

Didier HansUniversity of LausanneLausanne, Switzerland

Giancarlo IsaiaUnit of Geriatrics and Metabolic BoneDiseases. Molinette HospitalAO Città della Salute e della Scienzadi Torino School of Geriatric MedicineUniversity of Torino Italian Osteoporosis and Metabolic BoneDiseases Society (SIOMMMS)Torino, Italy

Davide LauroUniversity of “Tor Vergata”Rome, Italy

Andrea LenziUniveristy of “La Sapienza”Rome, Italy

Laura McCabeBiomedical Imaging Research CenterMichigan State UniversityEast Lansing, MI, USA

Silvia Migliaccio"Foro Italico" Universi tyRome, Italy

Geltrude MingronePoliclinico GemelliUniversità Cattolica del Sacro CuoreRome, Italy

Nicola Napoli University Campus Bio-Medico di Roma(UCBM)Rome, Italy

Paolo PozzilliUniversity Campus Bio-Medico di Roma(UCBM)Rome, Italy

Ann SchwartzUniversity of CaliforniaSan Francisco (UCSF)San Francisco, California, USA

17.30 L11 Design of clinical trials to evaluate skeletal benefit and risk in diabetic patientsH. Bone (USA)

18.00 Clinical round table and open debateH. Bone (USA), I. Chiodini (Italy), S. Epstein (USA)P. Falaschi (Italy), N. Napoli (Italy), A. Schwartz (USA)

18.30 End of the first day

Saturday, 8 November 2014

Chairpersons: D.Lauro (Italy), S. Migliaccio (Italy)

09.00 L12 Animal models of diabetic bone disease.Advantages and disadvantagesL. McCabe (USA)

09.30 L13 Latest advances in technology to assess diabeticbone diseaseD. Hans (Switzerland)

10.00 L14 Bone histomorphometry and bone MarkersD. Dempster (USA)

10.30 Coffee Break

Chairpersons: D. Dempster (USA), L. Gennari (Italy)

11.00 L15 Post transplant bone disease in diabeticsS. Epstein (USA)

11.30 L16 The role of the anti-aging gene Sirtuin1 in Diabetes and OsteoporosisR. Dresner-Pollak (Israel)

Lilly symposium - Not CME accredited

12.00 L17 Does Anabolic therapy have a role in the treatmentof diabetic bone diseaseN. Napoli (Italy)

12.30 Concluding remarks

13.00 End of the Meeting

Scientific programme

Friday, 7 November 201410.00 Registration

10.45 Welcome and introductionS. Epstein (USA), N. Napoli (Italy), P. Pozzilli (Italy)

Chairpersons: S. Epstein (USA), G. Isaia (Italy)

11.00 L1 New concepts and latest research directionsin the pathophysiology of diabetes P. Pozzilli (Italy)

11.30 L2 Osteoblasts in diabetic patients, too lazy or just insulin resistant?R. Civitelli (USA)

12.00 L3 The obesity epidemic, and the central role of adipose tissue in metabolic disordersM. Baroni (Italy)

12.30 L4 Diabetes and fractures. Is it a global health problem?B. Abrahamsen (Denmark)

13.00 Lunch

Chairpersons: B. Abrahamsen (Denmark), A. Giustina (Italy)

14.00 L5 Neuro endocrine, GUT hormones and BoneL. Baggio (Canada)

14.30 L6 Prevention of diabetes through bariatric surgeryG. Mingrone (Italy)

15.00 L7 Vitamin D and diabetesR. de Jongh (The Netherlands)

15.30 L8 Pathophysiology of diabetic bone diseaseA. Schwartz (USA)

16.00 Coffee Break

Chairpersons: I. Chiodini (Italy), A. Schwartz (USA)

16.30 L9 Incretin based treatments or old fashion medications,from diabetes treatment to bone healthN. Napoli (Italy)

17.00 L10 Implications for the treatment of osteoporosisin the diabetic patientN. Napoli (Italy)

Scientific programme

Session I

Session V

Session II

Session III The treatment of bone fragility in diabetic patients

Session IV

1st International meetingof diabetes and bone

Background and AimDiabetes is one of the fasting growing diseases in the western world andis becoming a huge problem in emerging economic power houses suchas India and Asia and particularly China. The number of patients isstaggering and the rate of newly diagnosed diabetics continues to grow.This is especially as Type 2 diabetes mellitus (DMT2) is associated withobesity which in itself is becoming a global health problem.Osteoporosis is another disease increasing due to aging populations andan accompanying increase in fractures. There are approximately 1.5million fractures per year in the USA .The population suffering low bonedensity is about 44 million, of which about 14 million are osteoporotic. Thecost of the disease has been estimated to be in the region of $22 billionannually. The mortality after a hip fracture is around 50 % in the first year.Rising morbidity is accompanied by loss of independence. Despite effectivedrugs reducing the fracture burden by about 50-60% the disease is stillnot recognized, diagnosed, or treated.

Learning objectivesBy attending this live educational meeting the learners will be able to:• Assess fracture risk in diabetic patients•Utilise the latest pathophysiology of bone fragility in diabetes•Utilise the latest diagnostic tools and treatment options for diabetesrelated fractures

Target audienceEndocrinologists, Diabetologists, Rheumatologists, Internal medicine andprimary care physicians.

Faculty members

Bo AbrahamsenInstitute of Clinical Research, SDUResearch Centre for Ageingand Osteoporosis, Department of Medicine M,Glostrup Hospital (Nord)Glostrup, Denmark

Laurie BaggioMt. Sinai HospitalSamuel Lunenfeld Research InstituteToronto, Ontario, Canada

Marco BaroniClinica MedicaUniversity of Rome “La Sapienza”Rome, Italy

Dennis BlackUniversity of CaliforniaSan Francisco (UCSF)San Francisco, California, USA

Henry BoneMichigan Bone and Mineral Clinic PCUniversity of MichiganDetroit, USA

Iacopo ChiodiniOspedale Maggiore Policlinico IRCCS Milan, Italy

Roberto CivitelliDivision of Bone and Mineral DiseasesMusculoskeletal Research CenterWashington University School of MedicineSt. Louis, Missouri, USA

Renate T. de JonghVU Medical CenterAmsterdam, The Netherlands

David DempsterCollege of Physicians and Surgeonsof Columbia UniversityRegional Bone Cente,Helen Hayes HospitalNew York State Department of HealthNew York, USA

Rivka Dresner-PollakHadassah-Hebrew University Medical Center Jerusalem, Israel

Sol EpsteinMt. Sinai School of Medicine New York, NY, USA

Paolo FalaschiUniversity of “La Sapienza”Rome, Italy

Luigi GennariUniversity of Siena“Santa Maria alle Scotte” HospitalSiena, Italy

Andrea GiustinaUniversity of BresciaBrescia, Italy

Didier HansUniversity of LausanneLausanne, Switzerland

Giancarlo IsaiaUnit of Geriatrics and Metabolic BoneDiseases. Molinette HospitalAO Città della Salute e della Scienzadi Torino School of Geriatric MedicineUniversity of Torino Italian Osteoporosis and Metabolic BoneDiseases Society (SIOMMMS)Torino, Italy

Davide LauroUniversity of “Tor Vergata”Rome, Italy

Andrea LenziUniveristy of “La Sapienza”Rome, Italy

Laura McCabeBiomedical Imaging Research CenterMichigan State UniversityEast Lansing, MI, USA

Silvia Migliaccio"Foro Italico" Universi tyRome, Italy

Geltrude MingronePoliclinico GemelliUniversità Cattolica del Sacro CuoreRome, Italy

Nicola Napoli University Campus Bio-Medico di Roma(UCBM)Rome, Italy

Paolo PozzilliUniversity Campus Bio-Medico di Roma(UCBM)Rome, Italy

Ann SchwartzUniversity of CaliforniaSan Francisco (UCSF)San Francisco, California, USA

17.30 L11 Design of clinical trials to evaluate skeletal benefit and risk in diabetic patientsH. Bone (USA)

18.00 Clinical round table and open debateD.Black (USA), H. Bone (USA), I. Chiodini (Italy)S. Epstein (USA), P. Falaschi (Italy), N. Napoli (Italy) A. Schwartz (USA)

18.30 End of the first day

Saturday, 8 November 2014

Chairpersons: D.Lauro (Italy), S. Migliaccio (Italy)

09.00 L12 Animal models of diabetic bone disease.Advantages and disadvantagesL. McCabe (USA)

09.30 L13 Latest advances in technology to assess diabeticbone diseaseD. Hans (Switzerland)

10.00 L14 Bone histomorphometry and bone MarkersD. Dempster (USA)

10.30 Coffee Break

Chairpersons: D. Dempster (USA), L. Gennari (Italy)

11.00 L15 Post transplant bone disease in diabeticsS. Epstein (USA)

11.30 L16 The role of the anti-aging gene Sirtuin1 in Diabetes and OsteoporosisR. Dresner-Pollak (Israel)

Lilly symposium - Not CME accredited

12.00 L17 Does Anabolic therapy have a role in the treatmentof diabetic bone diseaseN. Napoli (Italy)

12.30 Concluding remarks

13.00 End of the Meeting

Scientific programme

Friday, 7 November 201410.00 Registration

10.45 Welcome and introductionS. Epstein (USA), N. Napoli (Italy), P. Pozzilli (Italy)

Chairpersons: S. Epstein (USA), G. Isaia (Italy)

11.00 L1 New concepts and latest research directionsin the pathophysiology of diabetes P. Pozzilli (Italy)

11.30 L2 Osteoblasts in diabetic patients, too lazy or just insulin resistant?R. Civitelli (USA)

12.00 L3 The obesity epidemic, and the central role of adipose tissue in metabolic disordersM. Baroni (Italy)

12.30 L4 Diabetes and fractures. Is it a global health problem?B. Abrahamsen (Denmark)

13.00 Lunch

Chairpersons: B. Abrahamsen (Denmark), A. Giustina (Italy)

14.00 L5 Neuro endocrine, GUT hormones and BoneL. Baggio (Canada)

14.30 L6 Prevention of diabetes through bariatric surgeryG. Mingrone (Italy)

15.00 L7 Vitamin D and diabetesR. de Jongh (The Netherlands)

15.30 L8 Pathophysiology of diabetic bone diseaseA. Schwartz (USA)

16.00 Coffee Break

Chairpersons: I. Chiodini (Italy), A. Schwartz (USA)

16.30 L9 Incretin based treatments or old fashion medications,from diabetes treatment to bone healthN. Napoli (Italy)

17.00 L10 Implications for the treatment of osteoporosisin the diabetic patientD.Black (Usa)

Scientific programme

Session I

Session V

Session II

Session III The treatment of bone fragility in diabetic patients

Session IV

1st International meetingof diabetes and bone

Background and AimDiabetes is one of the fasting growing diseases in the western world andis becoming a huge problem in emerging economic power houses suchas India and Asia and particularly China. The number of patients isstaggering and the rate of newly diagnosed diabetics continues to grow.This is especially as Type 2 diabetes mellitus (DMT2) is associated withobesity which in itself is becoming a global health problem.Osteoporosis is another disease increasing due to aging populations andan accompanying increase in fractures. There are approximately 1.5million fractures per year in the USA .The population suffering low bonedensity is about 44 million, of which about 14 million are osteoporotic. Thecost of the disease has been estimated to be in the region of $22 billionannually. The mortality after a hip fracture is around 50 % in the first year.Rising morbidity is accompanied by loss of independence. Despite effectivedrugs reducing the fracture burden by about 50-60% the disease is stillnot recognized, diagnosed, or treated.

Learning objectivesBy attending this live educational meeting the learners will be able to:• Assess fracture risk in diabetic patients•Utilise the latest pathophysiology of bone fragility in diabetes•Utilise the latest diagnostic tools and treatment options for diabetesrelated fractures

Target audienceEndocrinologists, Diabetologists, Rheumatologists, Internal medicine andprimary care physicians.

Faculty members

Bo AbrahamsenInstitute of Clinical Research, SDUResearch Centre for Ageingand Osteoporosis, Department of Medicine M,Glostrup Hospital (Nord)Glostrup, Denmark

Laurie BaggioMt. Sinai HospitalSamuel Lunenfeld Research InstituteToronto, Ontario, Canada

Marco BaroniClinica MedicaUniversity of Rome “La Sapienza”Rome, Italy

Dennis BlackUniversity of CaliforniaSan Francisco (UCSF)San Francisco, California, USA

Henry BoneMichigan Bone and Mineral Clinic PCUniversity of MichiganDetroit, USA

Iacopo ChiodiniOspedale Maggiore Policlinico IRCCS Milan, Italy

Roberto CivitelliDivision of Bone and Mineral DiseasesMusculoskeletal Research CenterWashington University School of MedicineSt. Louis, Missouri, USA

Renate T. de JonghVU Medical CenterAmsterdam, The Netherlands

David DempsterCollege of Physicians and Surgeonsof Columbia UniversityRegional Bone Cente,Helen Hayes HospitalNew York State Department of HealthNew York, USA

Rivka Dresner-PollakHadassah-Hebrew University Medical Center Jerusalem, Israel

Sol EpsteinMt. Sinai School of Medicine New York, NY, USA

Paolo FalaschiUniversity of “La Sapienza”Rome, Italy

Luigi GennariUniversity of Siena“Santa Maria alle Scotte” HospitalSiena, Italy

Andrea GiustinaUniversity of BresciaBrescia, Italy

Didier HansUniversity of LausanneLausanne, Switzerland

Giancarlo IsaiaUnit of Geriatrics and Metabolic BoneDiseases. Molinette HospitalAO Città della Salute e della Scienzadi Torino School of Geriatric MedicineUniversity of Torino Italian Osteoporosis and Metabolic BoneDiseases Society (SIOMMMS)Torino, Italy

Davide LauroUniversity of “Tor Vergata”Rome, Italy

Andrea LenziUniveristy of “La Sapienza”Rome, Italy

Laura McCabeBiomedical Imaging Research CenterMichigan State UniversityEast Lansing, MI, USA

Silvia Migliaccio"Foro Italico" Universi tyRome, Italy

Geltrude MingronePoliclinico GemelliUniversità Cattolica del Sacro CuoreRome, Italy

Nicola Napoli University Campus Bio-Medico di Roma(UCBM)Rome, Italy

Paolo PozzilliUniversity Campus Bio-Medico di Roma(UCBM)Rome, Italy

Ann SchwartzUniversity of CaliforniaSan Francisco (UCSF)San Francisco, California, USA

17.30 L11 Design of clinical trials to evaluate skeletal benefit and risk in diabetic patientsH. Bone (USA)

18.00 Clinical round table and open debateD.Black (USA), H. Bone (USA), I. Chiodini (Italy)S. Epstein (USA), P. Falaschi (Italy), N. Napoli (Italy) A. Schwartz (USA)

18.30 End of the first day

Saturday, 8 November 2014

Chairpersons: D.Lauro (Italy), S. Migliaccio (Italy)

09.00 L12 Animal models of diabetic bone disease.Advantages and disadvantagesL. McCabe (USA)

09.30 L13 Latest advances in technology to assess diabeticbone diseaseD. Hans (Switzerland)

10.00 L14 Bone histomorphometry and bone MarkersD. Dempster (USA)

10.30 Coffee Break

Chairpersons: D. Dempster (USA), L. Gennari (Italy)

11.00 L15 Post transplant bone disease in diabeticsS. Epstein (USA)

11.30 L16 The role of the anti-aging gene Sirtuin1 in Diabetes and OsteoporosisR. Dresner-Pollak (Israel)

Lilly symposium - Not CME accredited

12.00 L17 Does Anabolic therapy have a role in the treatmentof diabetic bone diseaseN. Napoli (Italy)

12.30 Concluding remarks

13.00 End of the Meeting

Scientific programme

Friday, 7 November 201410.00 Registration

10.45 Welcome and introductionS. Epstein (USA), N. Napoli (Italy), P. Pozzilli (Italy)

Chairpersons: S. Epstein (USA), G. Isaia (Italy)

11.00 L1 New concepts and latest research directionsin the pathophysiology of diabetes P. Pozzilli (Italy)

11.30 L2 Osteoblasts in diabetic patients, too lazy or just insulin resistant?R. Civitelli (USA)

12.00 L3 The obesity epidemic, and the central role of adipose tissue in metabolic disordersM. Baroni (Italy)

12.30 L4 Diabetes and fractures. Is it a global health problem?B. Abrahamsen (Denmark)

13.00 Lunch

Chairpersons: B. Abrahamsen (Denmark), A. Giustina (Italy)

14.00 L5 Neuro endocrine, GUT hormones and BoneL. Baggio (Canada)

14.30 L6 Prevention of diabetes through bariatric surgeryG. Mingrone (Italy)

15.00 L7 Vitamin D and diabetesR. de Jongh (The Netherlands)

15.30 L8 Pathophysiology of diabetic bone diseaseA. Schwartz (USA)

16.00 Coffee Break

Chairpersons: I. Chiodini (Italy), A. Schwartz (USA)

16.30 L9 Incretin based treatments or old fashion medications,from diabetes treatment to bone healthN. Napoli (Italy)

17.00 L10 Implications for the treatment of osteoporosisin the diabetic patientD.Black (Usa)

Scientific programme

Session I

Session V

Session II

Session III The treatment of bone fragility in diabetic patients

Session IV

Improving the patient's life through medical educationwww.excemed.org

EXCEMED - Excellence in Medical EducationRepresentative OfficeSalita di San Nicola da Tolentino 1/B 00187 Rome, Italy.T +39.06.420.413, F +39.06.420.413.677

HeadquartersEXCEMED14, Rue du Rhone, 1204 Geneva, Switzerland

Copyright © EXCEMED, 2014. All rights reserved.

Generalinformation

AccreditationThe Italian National Commission for Continuing Medical Education hasaccredited this SIF SRL event n. 1841- 105289 (provider reference number- event reference number),“1st International Meeting of Diabetes andBone” (7-8 November, 2014, Rome, Italy) for N. 8 (eight) Italian CME credits.

This programme has been designed in partnership with the UniversitàCampus Bio-Medico di Roma (UCBM).

This programme is endorsed by SID (Società Italiana di Diabetologia), SIE(Società Italiana di Endocrinologia) and SIOMMMS (Società Italiana dell’Osteoporosi del Metabolismo Minerale e delle Malattie dello Scheletro).

PresidentsSol EpsteinMt. Sinai School of Medicine New York, NY, USA

Paolo Pozzilli University Campus Bio-Medico di Roma (UCBM)Rome, Italy

Scientific organisersSol Epstein Mt. Sinai School of Medicine New York, NY, USA

Nicola Napoli University Campus Bio-Medico di Roma (UCBM)Washington UniversityRome, Italy

VenueHotel ColumbusVia della Conciliazione, 33 - 00193 Roma, ItalyPhone: +39 06 686 5435

LanguageThe official language of this live educational workshop will be English.Simultaneous translation is provided from English to Italian and vice versa.

Organising secretariatEXCEMED - Excellence in Medical Education Salita San Nicola da Tolentino, 1/B - 00187 - Rome, ItalyProgramme Manager: Giovanna Rossi - info@excemed.org

Scientific SecretariatSocietà di Formazione Internazionale SRL Scientific Provider No. 1841

All EXCEMED programmes are organized solely to promote the exchangeand dissemination of scientific and medical information. No forms ofpromotional activities are permitted. This programme is made possiblethanks to educational grants received from:

Platinum grantor

Gold grantor

Silver grantor

Bronze grantor

Improving the patient's life through medical educationwww.excemed.org

EXCEMED - Excellence in Medical EducationRepresentative OfficeSalita di San Nicola da Tolentino 1/B 00187 Rome, Italy.T +39.06.420.413, F +39.06.420.413.677

HeadquartersEXCEMED14, Rue du Rhone, 1204 Geneva, Switzerland

Copyright © EXCEMED, 2014. All rights reserved.

Generalinformation

AccreditationThe Italian National Commission for Continuing Medical Education hasaccredited this SIF SRL event n. 1841- 105289 (provider reference number- event reference number),“1st International Meeting of Diabetes andBone” (7-8 November, 2014, Rome, Italy) for N. 8 (eight) Italian CME credits.

This programme has been designed in partnership with the UniversitàCampus Bio-Medico di Roma (UCBM).

This programme is endorsed by SID (Società Italiana di Diabetologia), SIE(Società Italiana di Endocrinologia) and SIOMMMS (Società Italiana dell’Osteoporosi del Metabolismo Minerale e delle Malattie dello Scheletro).

PresidentsSol EpsteinMt. Sinai School of Medicine New York, NY, USA

Paolo Pozzilli University Campus Bio-Medico di Roma (UCBM)Rome, Italy

Scientific organisersSol Epstein Mt. Sinai School of Medicine New York, NY, USA

Nicola Napoli University Campus Bio-Medico di Roma (UCBM)Washington UniversityRome, Italy

VenueHotel ColumbusVia della Conciliazione, 33 - 00193 Roma, ItalyPhone: +39 06 686 5435

LanguageThe official language of this live educational workshop will be English.Simultaneous translation is provided from English to Italian and vice versa.

Organising secretariatEXCEMED - Excellence in Medical Education Salita San Nicola da Tolentino, 1/B - 00187 - Rome, ItalyProgramme Manager: Giovanna Rossi - info@excemed.org

Scientific SecretariatSocietà di Formazione Internazionale SRL Scientific Provider No. 1841

All EXCEMED programmes are organized solely to promote the exchangeand dissemination of scientific and medical information. No forms ofpromotional activities are permitted. This programme is made possiblethanks to educational grants received from:

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Bronze grantor

Improving the patient's life through medical educationwww.excemed.org

EXCEMED - Excellence in Medical EducationRepresentative OfficeSalita di San Nicola da Tolentino 1/B 00187 Rome, Italy.T +39.06.420.413, F +39.06.420.413.677

HeadquartersEXCEMED14, Rue du Rhone, 1204 Geneva, Switzerland

Copyright © EXCEMED, 2014. All rights reserved.

Generalinformation

AccreditationThe Italian National Commission for Continuing Medical Education hasaccredited this SIF SRL event n. 1841- 105289 (provider reference number- event reference number),“1st International Meeting of Diabetes andBone” (7-8 November, 2014, Rome, Italy) for N. 8 (eight) Italian CME credits.

This programme has been designed in partnership with the UniversitàCampus Bio-Medico di Roma (UCBM).

This programme is endorsed by SID (Società Italiana di Diabetologia), SIE(Società Italiana di Endocrinologia) and SIOMMMS (Società Italiana dell’Osteoporosi del Metabolismo Minerale e delle Malattie dello Scheletro).

PresidentsSol EpsteinMt. Sinai School of Medicine New York, NY, USA

Paolo Pozzilli University Campus Bio-Medico di Roma (UCBM)Rome, Italy

Scientific organisersSol Epstein Mt. Sinai School of Medicine New York, NY, USA

Nicola Napoli University Campus Bio-Medico di Roma (UCBM)Washington UniversityRome, Italy

VenueHotel ColumbusVia della Conciliazione, 33 - 00193 Roma, ItalyPhone: +39 06 686 5435

LanguageThe official language of this live educational workshop will be English.Simultaneous translation is provided from English to Italian and vice versa.

Organising secretariatEXCEMED - Excellence in Medical Education Salita San Nicola da Tolentino, 1/B - 00187 - Rome, ItalyProgramme Manager: Giovanna Rossi - info@excemed.org

Scientific SecretariatSocietà di Formazione Internazionale SRL Scientific Provider No. 1841

All EXCEMED programmes are organized solely to promote the exchangeand dissemination of scientific and medical information. No forms ofpromotional activities are permitted. This programme is made possiblethanks to educational grants received from:

Platinum grantor

Gold grantor

Silver grantor

Bronze grantor