salivary gland comp and func2
DESCRIPTION
power point presentation about anatomy and function of salivary glandsTRANSCRIPT
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Salivary gland anatomy and function
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Types
Major
1) Parotid
2) Submandibular
3) Sublingual
Minor
1) Buccal
2) Labial
3) Palatal
4) Lingual
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Serous Mucous
Mixed
Secretion
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Parotid gland
1st to develop and last to be encapsulated Lymphatic's are entrapped in the parenchyma
of the gland Salivary epithelial cells are often entrapped in
these lymph node which may give rise to warthins tumor.
Other major salivary glands DON’T HAVE
intraparenchymal entrapments
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Location
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External features - pyramid
Surfaces - 4
1. Superior
2. Superficial
3. Anteromedial
4. Posteromedial
Borders -3
1. Anterior
2. Medial
3. Posterior
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Parotid capsule
Investing layer of deep cervical fasciaSplits to enclose the glandSuperficial lamina thick and adherent attached to zygomatic arch
Deep lamina thin and attached to styloid
process, mandible below and tympanic plate above
Stylomandibular ligament
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Relation - external
Apex –a) overlaps the posterior belly of digastric
b) cervical branch of facial and two division of retromolar
comes out through it
Superficial surface –
skin and fascia containing anterior branches of great auricular nerve and lymph nodes
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Relation
Anteromedial – a) posterior border of mandible b)masseter, c)lateral surface of TMJ, d) emerging branches of facial nerve
Poseriomedial surface – a) mastoid process b)styloid process c)external carotid artery entry.
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Anterior border – structure emerging through It are
a) duct
b) terminal branches of facial nerve
c) transverse facial vessel Posterior border separates superficial
and posteriomedial surface
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Medial border is related to lateral wall of pharynx
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Relations – internal
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Facial nerve relation
Emerges out of stylomastoid foramen Almost immediately comes in relation
with parotid gland Enters through posteriomedial surface
divides into five branches and leaves through anteromedial surface
Folded or interwoven?
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Branches of the Facial N
The nerve then gives rise to 2 divisions: 1) Temperofacial (upper) 2) Cervicofacial (lower)
Followed by 5 terminal branches: 1) Temporal 2) Zygomatic 3) Buccal 4) Marginal Mandibular 5) Cervical
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Facial Nerve
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Parotid gland duct -
Stensen’s duct is 5 cm long.
Arises from the anterior part of the gland and runs over the masseter one finger below the zygomatic arch to pierce the buccinator and open opposite the second upper molar tooth
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Parotid Duct orifice
Clinical examination of the parotid gland should include examination of the duct orifice opposite the upper 2nd molar for signs of inflammation, and palpated for stone
Parotid Sialogram is performed by injecting a contrast through a canula placed in the orifice of the duct
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Nerve supply
Parasympathetic nerves are secretomotor reach the gland through auriculotemporal nerve
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Nerve supply
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Symphathetic fibers are vasomtor and derived from plexus around external carotid artery
Sensory nerves come from auriculotemporal nerve but parotid fascia is innervated by greater auricular nerve c2
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Frey syndrome, gustatory sweating
Usual after parotidectomy Caused by regeneration of secretory
fibers of parotid gland to sweat glands in its area of distribution
So the sweat glands respond to nerve impulses that should provoke the parotid secretion
starch-iodine test is used
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Treatment
Medical - antiperspirants,, 3% scopolamine cream.
Surgical -tympanic neurectomy
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Blood supply
Supplied by external carotid artery and its branches that arises near the gland
Drains into internal external jugular vein
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Submandibular gland
Anterior part of digastric triangle
“J” shaped, indented by mylohyoid muscle
Large part superficial to muscle and small part deep to it
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Capsule
Enclosed in capsule formed by deep cervical fascia
Loosely attached unlike parotid gland fascia hence can be shelled out
The superficial lamina is attached to base of the mandible and deep fascia is attached to mylohyoid line
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Superficial and Deep Relations
Superficially: The skin, the platysma, the capsule (deep fascia), the cervical branch of Facial Nerve, and the Facial Vein
Deeply: the deep aspect lies against the mylohyoid for the most part. But posteriorly lies on the hyoglossus and comes in contact with the lingual and hypoglossal nerves.
Both nerves lie on the hyoglossus as they pass forward to the tongue
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The facial Artery Arches over its
superior aspect to reach inferior border of the mandible and then ascends on to the face in front of the masseter
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Submandibular duct
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In its terminal course it may receive a major sublingual duct called bartholins duct
Sublingual papilla lateral to the freenum
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Blood supply
Supplied by facial artery Veins drain into common facial and
lingual vein
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Sublingual gland
Long flattened body situated in the shallow depression on the mandible called as sublingual fovea
Covered by thin mucous membrane and causes elevation called as salivary eminence
it is a glandular complex since there is no common duct for all the lobules
But the major part of the gland drains into Bartholins duct which latter drains into Warthons duct or opens close to it
Dozen or more small ducts called duct of Rivinus open directly in to the oral cavity from the upper border of the gland
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Nerve supply - Parasympathetic
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contd
Sensory from the lingual nerveParasympathetic from the plexus around
the facial artery
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Effect of nerve stimulation
Superior salivatory nucleus for submandibular and sublingual
Inferior salivatory nucleus for parotid Parasympathetic Stimulation results in
abundant, watery saliva with a decrease in [amylase] in saliva
Stimulation by the sympathetic nervous system results in a scant, viscous saliva rich in solutes with an increase in [amylase] in the saliva
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For all of the salivary glands, these fibers originate in the Superior Cervical ganglion and travel with arteries to reach the glands:
1) External Carotid artery for the Parotid 2) Lingual artery for the Submandibular, and 3) Facial artery in the case of the Sublingual. Parasympathetic Interruption to salivary
glands results in atrophy, while sympathetic interruption doesn’t cause a significant change.
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Minor salivary glands - lingual
Anterior part of tongue near its inferior surface - gland of Blandin
Base of the tongue at the dorsal surface - the von Ebner gland –empties in into vallat papillae
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saliva – composition and function
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THE SECRETORY UNITThe basic building block of all salivary glands
ACINI - water and ions derived from plasma
Saliva formed in acini flows down DUCTS to empty into the oral cavity.
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TWO STAGE HYPOTHESIS OF SALIVA FORMATION
Water & electrolytes
Isotonic primary saliva
Most proteins
Some proteins electrolytes
Na+ Cl- resorbed
K+ secreted
Hypotonic final saliva into mouth
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contd
Resting condition – sodium and chloride ions are 1/10th of plasma concentration
potassium is 7 times more than in plasma
bicarbonate is 2 – 3 times more than in plasma
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During maximal stimulation
sodium and chloride
potassium Effect of aldostoron Excess loss of saliva to the exterior of
body may lead to hypokalemia and paralysis
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Composition
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Inorganic components
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Calcium and phosphate
Calcium sublingual > submandibular > parotis
Phosphate Help to prevent dissolution of dental
enamelpH around 6 - hydroxyapatite is unlikely to
dissolveIncrease of pH - precipitation of calcium
salts => dental calculus
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Hydrogen carbonate
BufferLow in unstimulated saliva, increases with
flow ratePushes pH of stimulated saliva up to 8pH 5,6 critical for dissolution of enamelDefence against acids produced by
cariogenic bacteriaDerived actively from CO2 by carbonic
anhydrase
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Other ions Fluoride
Low concentration, similar to plasma
Thiocyanate Antibacterial (oxidated to hypothiocyanite OSCN- by
active oxygen produced from bacterial peroxides by lactoperoxidase)
Higher conc. => lower incidence of caries Smokers - increased conc.
Sodium, potassium, chloride Lead, cadmium, copper
May reflect systemic concentrations - diagnostics
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Organic components
Saliva composition
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Organic components of saliva Mucins Proline-rich proteins Amylase Lipase Peroxidase Lysozyme Lactoferrin sIgA Histatins Statherin Blood group substances, sugars, steroid hormones,
amino acids, ammonia, urea
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MultifunctionalityMultifunctionality
SalivarySalivaryFamiliesFamilies
Anti-Anti-BacterialBacterial
BufferingBuffering
DigestionDigestion
Mineral-Mineral-izationization
Lubricat-Lubricat-ion &Visco-ion &Visco-elasticityelasticity
TissueTissueCoatingCoating
Anti-Anti-FungalFungal
Anti-Anti-ViralViral
Carbonic anhydrases,Carbonic anhydrases,HistatinsHistatins
Amylases,Amylases,Mucins, LipaseMucins, Lipase
Cystatins,Cystatins,Histatins, Proline-Histatins, Proline-rich proteins,rich proteins,StatherinsStatherins
Mucins, StatherinsMucins, Statherins
Amylases,Amylases,Cystatins, Mucins, Cystatins, Mucins, Proline-rich proteins, StatherinsProline-rich proteins, Statherins
HistatinsHistatins
Cystatins,Cystatins,MucinsMucins
Amylases, Cystatins,Amylases, Cystatins,Histatins, Mucins,Histatins, Mucins,PeroxidasesPeroxidases
adapted from M.J. Levine, 1993adapted from M.J. Levine, 1993
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Mucins
LubricationGlycoproteins - protein core with many
oligosaccharide side chains attached by O-glycosidic bond
More than 40% of carbohydratesHydrophillic, entraining water (resists
dehydration)Unique rheological properties (e.g., high
elasticity, adhesiveness, and low solubility)Two major mucins (MG1 and MG2)
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Amylases – (ptyalin) Hydrolyzes (1-4) bonds of starches such as
amylose and amylopectin Maltose is the major end-product (20% is
glucose) Considered to be a good indicator of properly
functioning salivary glands Parotid gland saliva has highest content(80%) Its action is inactivated in the acid portions of the
gastrointestinal tract and is consequently limited to the mouth.
Provides disaccharides for acid-producing bacteria
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Lingual Lipase
Secreted by lingual glands and parotisInvolved in first phase of fat digestionHydrolyzes medium- to long-chain
triglyceridesImportant in digestion of milk fat in
new-born
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Statherins
Calcium phosphate salts of dental enamel are soluble under typical conditions of pH and ionic strength
Supersaturation of with calcium and phosphates maintain enamel integrity
Statherins prevent precipitation or crystallization of supersaturated calcium phosphate in ductal saliva and oral fluid
Also an effective lubricant
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Proline-rich Proteins (PRPs)
40% of AAs is prolineInhibitors of calcium phosphate crystal
growth
Present in the initially formed Present in the initially formed enamel pellicle and in “mature” enamel pellicle and in “mature” pelliclespellicles
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Lactoferrin
Iron-binding protein Links to free iron in the saliva causing
bactericidal or bacteriostatic effects on various microorganisms requiring iron for their survival such as the Streptococcus mutans group.
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Lysozyme
Present in numerous organs and most body fluids
Hydrolysis of (1-4) bond between N-acetylmuramic acid and N-acetylglucosamine in the peptidoglycan layer of bacteria.Gram negative bacteria generally more resistant
than gram positive because of outer LPS layeraggregation and inhibition of bacterial
adherence
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Histatins
A group of small histidine-rich proteinsPotent inhibitors of Candida albicans
growthThe bactericidal and fungicidal effects
occur through the destruction of their architecture and altering their permeability.
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Cystatins
Are inhibitors of cysteine-proteasesAre ubiquitous in many body fluidsConsidered to be protective against
unwanted proteolysisbacterial proteases
May inhibit proteases in periodontal tissues
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Salivary peroxidase systems
Sialoperoxidase (SP, salivary peroxidase) Produced in acinar cells of parotid glands Also present in submandibular saliva Readily adsorbed to various surfaces of mouth
enamel, salivary sediment, bacteria, dental plaque
Myeloperoxidase (MP) From leukocytes entering via gingival crevice 15-20% of total peroxidase in whole saliva
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Components of the peroxidase anti-microbial system
Peroxidase enzymes (SP or MP)Hydrogen peroxide (H2O2)
oral bacteria (facultative aerobes/catalase negative) produce large amounts of peroxide
S. sanguis, S. mitis, S. mutans
Thiocyanate ion (SCN-) which is converted to hypothiocyanite ion (OSCN-) by peroxidase
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Thiocyanate reactions
More acid favors HOSCNDue to uncharged nature, HOSCN
penetrates bacterial cell envelope better
HH22OO22 + + SCNSCN-- OSCN-OSCN- + +HH22OOSP and/or MPSP and/or MP
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HOSCN/OSCN--mediated cell damage
can oxidize sulfhydryl groups of enzymesblock glucose uptakeinhibit amino acid transportdamage inner membrane, leading to leakage
of celldisrupt electrochemical gradients
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Immunoglobulin
Secretory immunoglobulin A (IgA) is the largest immunologic component of saliva. It can neutralize viruses, bacterial, and enzyme toxins
It serves as an antibody for bacterial antigens and is able to aggregate bacteria
IgG and IgM, occur in less quantity and probably originate from gingival fluid.
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Tissue Repair
Tissue repair function is attributed to saliva since clinically the bleeding time of oral tissues appears to be shorter than other tissues
Experimental studies in mice have shown wound contraction is significantly increased in the presence of saliva due to the epidermal growth factor it contains which is produced by the submandibular glands
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Xerostomia – symptom not a disease
Temporary
1. Calculi
2. Psychological
3. Drugs
Permanent
1. Aplasia
2. Removal of gland
3. Sjogrens syndrome
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Factors affecting flow of saliva
Individual Hydration Body Posture- Patients kept standing up or
lying down present higher and lower SF, respectively
The Circadian and Circannual Cycle Medications- antidepressants,, antipsychotics,
antihistaminics, and antihypertensives) Age Gender Lighting