sales offices : austria designed by scientists for ... · 4 biopharmaceutical system solution with...

[Product Guide 2011]

SaleS OfficeS:

Austria 43 1 877 18 07

Australia 61 2 9933 1777

Belgium and Luxembourg 32 2 726 1000

Brazil 55 11 4134 3788

Canada 1 800 252 4752

China 86 21 6156 2666

Czech Republic 420 2 617 11384

Denmark 45 46 59 8080

Finland 358 9 5659 6288

France 33 1 30 48 72 00

Germany 49 6196 400 600

Hong Kong 852 2964 1800

Hungary 36 1 350 5086

India 91 80 2837 1900

Ireland 353 1 448 1500

Italy 39 02 265 0983

Japan 81 3 3471 7191

Korea 82 2 6300 4800

Mexico 52 55 52 00 1860

The Netherlands 31 76 508 7200

Norway 47 6 384 6050

Poland 48 22 833 4400

Puerto Rico 1 787 747 8445

Russia/CIS 495 727 4490 / 290 9737

Singapore 65 6593 7100

Spain 34 93 600 9300

Sweden 46 8 555 115 00

Switzerland 41 56 676 7000

Taiwan 886 2 2501 9928

UK 44 208 238 6100

US 1 800 252 4752

ACQUITY, ACQUITY UPLC, Alliance, Atlantis, AutoPurification, AutoSpec, Connections INSIGHT, ESCi, GCT Premier, nanoACQUITY UPLC, NuGenesis, Oasis, PATROL, Pico•Tag, Sep-Pak, StepWave, Symbiosis, Symmetry, SYNAPT, Triwave, UPLC, Waters, Waters Quality Parts, and Xevo are registered trademarks of Waters Corporation. AccQ•Tag, Auto•Blend, Auto•Blend Plus, AutoSpec, BiopharmaLynx, BioSuite, Breeze, ChromaLynx, CSH, DisQuE, DriftScope, E High Definition Proteomics, Empower, Engineered Simplicity, Expression, FractionLynx, HDI, HDMS, High Definition MS, i-FIT, IntelliStart, MALDI SYNAPT, MarkerLynx, MassFragment, MassLynx, MassPREP, MetaboLynx, OBD, OpenLynx, OpenQuan, Ostro, PoraPak, POSI+IVE, ProteinLynx Global SERVER, QuanOptimize, Quattro micro, Quattro Premier, RADAR, Real-TIME LC, ScanWave, SDMS Vision Publisher, Sirocco, SunFire, TargetLynx, TRIZAIC nanoTile, TRIZAIC UPLC, UNIFI, UPSFC, VanGuard, Viridis, XBridge, and XSelect, and T he Science of What’s Possible, are trademarks of Waters Corporation. S-Matrix and Fusion are trademarks of S-Matrix Corporation. All other trademarks are the property of their respective owners.

©2011 Waters Corporation. Printed in the U.S.A. March 2011 720002048EN LL-CP

Waters Corporation 34 Maple StreetMilford, MA 01757 U.S.A.T: 508 478 2000F: 508 872 1990www.waters.com

Designed by scientists for scientists, Waters solutions remove the guesswork in choosing the best way to achieve your application’s goals.

Whether you work in pharmaceuticals, biopharmaceuticals, environmental,

food testing, clinical, or beyond, with Waters application focused solutions,

you can be assured that whenever a new analytical challenge arises,

Waters will have the technology and expertise to help you conquer it.

These solutions provide a comprehensive approach to address analytical

lab needs that include instrumentation, columns and sample prep,

software, and support services.

53 54

Food Profiling

■■ Detect adulteration■■ Assure authenticity■■ Confirm origin

Food QC and Nutritional Testing

■■ Raw material■■ Consistency■■ In-process monitoring■■ Final product quality■■ Verifying composition

and label claims■■ Amino acid analysis

in food and feed

Food Safety

■■ Pesticides■■ Veterinary drug

residues■■ Mycotoxins■■ Marine biotoxins■■ Processing

contaminants

Forensics

■■ Drugs of abuse■■ Toxicology

Polymers

■■ Polymer additives■■ Starch■■ Molecular weight

distributions

Proteomics

■■ Characterization■■ Quantification■■ Biomarker validation■■ Identification■■ Bioseparations/

interactions

Tissue Imaging

■■ Biomarker discovery■■ Drug/metabolite

distributions

Pharmaceutical

■■ ADME screening■■ Bioanalysis■■ Bioequivalence■■ Compound library

maintenance■■ Dissolution testing■■ Forced degradation■■ Impurity profiling■■ Manufacturing■■ QA/QC■■ Metabolite

identification■■ Lipidomics■■ Metabolomics■■ Method development■■ Method validation■■ Natural products■■ Traditional

medicine analysis■■ Open access

11

3 Featured Systems

6 UPLC

10 UPLC for Process Development and Manufacturing

12 Nanoscale UPLC

14 UPSFC

16 HPLC

18 HPLC and SFC Purification

20 SFe

22 Quantitative and Qualitative UPLC/MS

24 Quantitative UPLC/MS/MS

26 exact Mass UPLC MS/MS

28 exact Mass UPLC/MALDI MS/MS

30 UPLC/MALDI IMS-MS

32 Universal Ionization Architecture

34 exact Mass GC/MS

36 Quantitative GC/MS AND GC/MS/MS

38 HPLC and SFC Column Solutions

40 UPLC Column Solutions

42 Bioseparations and Analyses Solutions

44 Sample Preparation Solutions

46 Laboratory Informatics Solutions

48 Global Services

50 Waters Centers of Innovation Program

52 Application Solutions

[con

ten

ts]

2

Customer suCCess is our mission

Waters creates business advantages for laboratory

dependent organizations by delivering practical and

sustainable scientific innovation to enable significant

advancements in such areas as healthcare delivery,

environmental management, food safety, and water

quality worldwide.

Bringing keen understanding and deep experience to

those responsible for laboratory infrastructure and

performance, Waters helps customers make profound

discoveries, optimize lab operations, deliver product

performance, and ensure regulatory compliance.

Pioneering a connected portfolio of separation and

analytical science, laboratory informatics, and mass

spectrometry, Waters’ technology breakthroughs and

laboratory solutions provide an enduring platform

for customer success.

3

[ featured syst ems ]

Biopharmaceutical System Solution with UNIFI.

Waters systems combine the latest

generation of instrumentation,

software, consumables, and columns,

and are designed to streamline

your specific laboratory workflow.

Our solutions help analysts satisfy

compliance regulations, increase

laboratory productivity, and make

the best decisions possible.

4

Biopharmaceutical System Solution

with UNIFI™ integrates robust UPLC®/MS

characterization technology with UNIFI

Scientific Information System. UNIFI

is an industry first comprehensive

software solution that uniquely unites

all aspects of biotherapeutic analyses

and workflows, enabling organizations

to apply high-resolution analytics across

the development process continuum.

This application-focused platform,

featuring ACQUITY UPLC® H-Class Bio

and Xevo® G2 Tof technologies, captures

complex mass spectrometry and

chromatography data, in conjunction

with next-generation bioinformatics and

GxP data management capabilities.

[ featured syst ems ]

ACQUITY UPLC H-Class Method

Development System automates

chromatographic method development

according to Quality-by-Design (QbD)

guidelines to produce robust, fit-for-

purpose methods in dramatically less

time than traditional processes. The

superior performance of the system

stems from the power and integration

of four class-leading components:

ACQUITY UPLC H-Class; Fusion Method

Development™ Software; empower™ 3

Chromatography Data Software;

and Waters® Method Development

Chemistry kits.

PATROL UPLC Laboratory Analyzer

System introduces proven UPLC

Technology to reaction monitoring

and optimization experiments. This

system integrates sample prep and

Real-TIMe LC™ analysis in an automated

analyzer providing fast and accurate

quantitative results to define a

process method.

5

ACQUITY UPSFC™ System is the world’s

first UPLC-based system for SFC. This

game-changing UPSFC™ solution enables

you to confidently conduct normal phase

chromatographic separations – including

chiral and achiral applications – using

carbon dioxide as the main mobile phase.

Now you can minimize harmful waste while

gaining superior selectivity, resolution,

and speed.

ACQUITY UPLC H-Class Bio System

delivers the benefits of UPLC’s resolution,

sensitivity, and throughput in a quaternary

system purpose-built for the analysis

of proteins, peptides, nucleic acids, and

glycans. Featuring Auto•Blend Plus™

Technology, this is the ideal system for

the separation of complex biomolecules

that require multiple chromatographic

techniques for complete characterization,

including reversed phase (RP), ion exchange

(IeX), size exclusion (SeC), or hydrophilic

interaction (HILIC).

UPLC with On-Line SPE Technology

streamlines the analysis of drinking water

samples by providing analyte extraction,

clean-up, concentration, separation, and

detection in one turn-key solution.

Xevo G2 Tof technology offers the most

sensitive, exact mass quantitative and

qualitative performance of any benchtop

MS system for scientists who need to

confidently identify and quantify unknown

compounds in complex samples.

Waters has developed the MassTrak™

range of integrated system solutions to

meet the needs of clinical laboratories,

transplant hospitals, and reference

laboratories. Today we offer complete

solutions, reliable results, and unparalleled

support in the fields of therapeutic

drug monitoring, metabolic disease,

endocrinology, and toxicology.

6 Join the ACQUITY UPLC community at www.waters.com/MYUPLC

[ uPlc ]

Access the productivity and

chromatographic performance of

UPLC with the familiarity of HPLC

using the Waters ACQUITY UPLC

H-Class System.

Laboratories can now achieve

UPLC results with a system that

combines the flexibility of ternary

or quaternary solvent blending

with the simplicity of flow-through

needle injections. You can even

continue running your existing

HPLC methods with this forward

looking platform and seamlessly

transition to UPLC separations

when you’re ready.

Applications■■ HPLC and UPLC analyses

with easy method transferability■■ Routine analysis■■ Method development■■ Quality assurance and

quality control

Key Technologies■■ ACQUITY UPLC H-Class System■■ ACQUITY UPLC H-Class Bio System■■ ACQUITY UPLC H-Class Method

Development System■■ ACQUITY UPLC H-Class System

with 2D technology■■ Quaternary Solvent Management■■ Auto•Blend™ and

Auto•Blend Plus™ Technology■■ Photodiode Array, Tunable UV,

Fluorescence, and evaporative Light Scattering UPLC detectors

■■ ACQUITY® single and tandem quadrupole detectors

■■ empower™ or MassLynx™ software■■ Local Console Controller for handheld

remote operation■■ Connections INSIGHT® Remote Services■■ ACQUITY UPLC BeH, CSH, HSS,

VanGuard™ columns and chemistries■■ ACQUITY UPLC Method Development

and Method Transfer kits

7

ACQUITY UPLC H-Class System.

8

[ uPlc ]

The ACQUITY UPLC System

is the original UPLC system

introduced over six years ago.

This UPLC system allows analytical

chemists to reach far beyond

conventional LC separations

and proves itself to be an asset

to laboratories around the

world. UPLC Technology sets

new standards in resolution,

sensitivity, and throughput

by being the first holistically-

designed system that maximizes

the performance of sub-2-μm

particles. It has fueled more than

500 peer reviewed papers, helps

laboratories conserve resources,

and serves the needs of regulatory

agencies around the globe.

ACQUITY UPLC simultaneously

makes your laboratory more

sustainable and more efficient.

Applications■■ Qualitative and quantitative analyses■■ Analysis of samples in complex matrices■■ Trace analysis■■ High-throughput and open access runs■■ Method development■■ Clinical and diagnostic

Key Technologies■■ ACQUITY UPLC System■■ ACQUITY UPLC System with

2D technology■■ UPLC Open Architecture System■■ UPLC with On-Line SPe Technology■■ Binary Solvent Management■■ Superior inlet to mass spectrometry

independent of vendor■■ ACQUITY UPLC Photodiode Array,

Tunable UV, Fluorescence, and evaporative Light Scattering UPLC detectors

■■ ACQUITY UPLC single and tandem quadrupole mass detectors

■■ empower or MassLynx software■■ Local Console Controller for handheld

remote operation■■ Connections INSIGHT Remote Services■■ ACQUITY UPLC BeH, CSH, HSS, and

VanGuard columns and chemistries■■ ACQUITY UPLC Aflatoxin and

Perfluorinated Compound kits

9

ACQUITY UPLC System with Sample Organizer.

“ Waters introduced the technique onto the market under the name UPLC in 2004, using columns with 1.7 μm diameter spherical particles and a pumping capability of up to 15,000 psi. UPLC allowed industrial, commercial, and research laboratories to take full advantage of improved separation, and thus 2004 marked a new era of great steps forward in productivity, quality, sample throughput, and cost reduction.”

Baltussen EA, Noij THM.NOTOX BV European Pharmaceutical Contractor.2009 Jun; 36-40.

10 Learn more at www.waters.com/PATROL

[ uPlc fOr PrOcess deV elOPmeNt aNd maNufacturING ]

Waters’ new PATROL UPLC

Laboratory Analyzer System is

designed for reaction monitoring

and optimization experiments.

It integrates sample prep and

Real-TIME LC analysis in an

automated analyzer providing fast,

and accurate quantitative results

to define a process method.

Waters PATROL UPLC Process

Analyzer System is a real-time

Process Analytical Technology

(PAT) system that detects and

quantifies complex multiple

component manufacturing samples

and final product directly on the

production floor.

The validated methods transferred

from the PATROL UPLC Laboratory

Analyzer to the PATROL UPLC

Process Analyzer ensure regulatory

compliance on the manufacturing

floor as well as results that

improve operational efficiency,

deliver quantifiable ROI, and

increase profits.

Applications■■ Real-TIMe LC analysis in

manufacturing processes■■ Quantitative measurement

of Critical Quality Attributes■■ Process development■■ Cleaning validation■■ Process reaction monitoring■■ Development reaction

optimization and characterization

Key Technologies■■ PATROL UPLC Laboratory

Analyzer System■■ PATROL UPLC Process Analyzer System■■ Online and atline configurations■■ empower Software■■ NuGenesis® SDMS Information Platform■■ ACQUITY UPLC Columns■■ Connections INSIGHT Remote Services

11

[ uPlc fOr PrOcess deV elOPmeNt aNd maNufacturING ]

“ …A fast LC technique like Waters’ UltraPerformance LC® (UPLC) may be time-equivalent to techniques like near-infrared, UV, and Raman, providing what amounts to real-time analysis …Data from [PATROL] UPLC experiments is impressive. For real-time analysis, UPLC does not demand a trade-off among resolution, sensitivity, and speed. UPLC routinely separates complex solutions in less than 30 seconds.”

DePalma A.Writer, editor, and ConsultantGenetic Engineering & Biotechnology News.2008 Jun; 28(11).

PATROL UPLC System.

12

[ NaNOscale uPlc ]

The nanoACQUITY UPLC® System

has been designed for microbore

to nanoscale separations to

attain the highest sensitivity and

chromatographic resolution for

UPLC and UPLC/MS. It allows

scientists to achieve separations

at nanoflow rates without flow-

splitting, offering significant

improvements in robustness,

reproducibility, and simplicity

of operation over conventional

nanoflow separations technologies.

Also available with 2D capabilities

for increased peak capacity and

dynamic range.

Optional TRIZAIC™ UPLC

Technology provides

UPLC performance in a user-

friendly platform for sample

limited separations.

Applications■■ Biomarker discovery■■ Protein identification■■ Protein characterization■■ Metabolite identification

Key Technologies■■ nanoACQUITY UPLC System■■ nanoACQUITY UPLC System

with 2D Technology■■ nanoACQUITY System with

HDX Technology■■ Atlantis®, Symmetry®, and

BeH chemistries■■ Waters MS and HDMS™ technologies■■ Superior mass spectrometry inlet■■ nanoACQUITY UPLC Columns■■ TRIZAIC UPLC nanoTile™

13

nanoACQUITY UPLC System.

“ The nanoACQUITY [UPLC] System is a high-pressure nanoflow pump that can deliver flow rates down to hundreds of nanoliters per minute, and this is important because of the reproducibility requirements for the protein expression profiling. Another innovation that Waters has come forth with is small particle LC packing that delivers superior peptide separation. That truly is a step forward in our ability to see low-level proteins in this complex mixture.”

Cavey G.Special Program Investigator,Van Andel Institute

14 Learn more at www.waters.com/UPSFC

[ uPsfc ]

Experience analytical supercritical

fluid chromatography (SFC)

like never before with Waters new

ACQUITY UPSFC System. This

normal phase chromatagraphic

solution uses CO2 as the main

mobile phase, reducing solvent

and waste. Now you can run

normal phase chiral and achiral

applications using superior

performance with this holistically

designed, UPLC-based SFC

system integrated with Waters

Viridis™ SFC Columns.

Applications■■ Normal phase applications ■■ Achiral analysis■■ Chiral analysis■■ Pharmaceutical■■ Fine chemicals

Key Technologies■■ ACQUITY UPSFC System■■ ACQUITY UPSFC Binary

Solvent Manager■■ ACQUITY UPSFC PDA Detector■■ Single and tandem quadrupole

mass detectors■■ empower or MassLynx software■■ Connections INSIGHT

Remote Services■■ Viridis SFC Column chemistries

15

ACQUITY UPSFC System.

16 Learn more at www.waters.com/HPLC

[HPlc ]

Whatever your application,

the Alliance® HPLC and

Breeze™ 2 HPLC systems offer

you proven solutions for all

of your HPLC requirements –

today and in the future. These

systems are synonymous

with dependable, routine

performance, and versatility.

Applications■■ Fine and specialty chemicals■■ Food safety analysis■■ environmental analysis■■ Quality control■■ Clinical/diagnostics■■ Pharmaceutical

Key Technologies■■ Alliance HPLC and HPLC/MS systems■■ Alliance HPLC Dissolution System■■ Alliance HPLC Bioseparations System■■ BioSuite™ Bioseparation Columns■■ Breeze 2 HPLC systems■■ empower or MassLynx software■■ UV/Visible, Photodiode Array,

evaporative Light■■ Scattering, Multi-λ Fluorescence,

Refractive Index, electrochemical, and Conductivity HPLC detectors

■■ Alliance HPLC System with the 3100 Mass Detector

17

Alliance HPLC System with the 3100 Mass Detector.

“ …[Alliance HPLC] methods used in the present paper are reliable, easy and fast to perform…The large number of patients tested here demonstrates that the UV method has sufficient selectivity and accuracy for the analysis of patients’ samples… Moreover, one major benefit of HPLC–UV is its availability in hospitals and small laboratories…”

Awidi A, et al.Professor of Medicine, Hematology and OncologyJordan UniversityLeuk Res.2009 Sep 8.

18 www.waters.com/PREP

[ HPlc aNd sfc PurIfIcat ION ]

Waters’ robust purification

solutions are uniquely flexible

and scalable, from high-throughput

fraction collection of hundreds

of samples, to simple systems

for purifying just a handful of

samples a day. Offering MS and

UV capabilities with our HPLC and

supercritical fluid chromatography

(SFC) innovations, a full range

of Optimum Bed Density (OBD™)

and Viridis SFC Columns, and

world-class service and support,

Waters is your single-vendor

solution that encompasses the

entire purification range.

Applications■■ Compound isolation and purification■■ UV- or mass-directed fraction collection■■ Milligram to kilogram amounts■■ Pharmaceutical■■ Biopharmaceutical■■ Natural products and traditional

Chinese herbal medicines

Key Technologies■■ AutoPurification™ LC and

LC/MS systems■■ SFC Prep 100 UV and MS systems■■ empower or MassLynx software■■ FractionLynx™ Application Manager■■ OpenLynx™ Open Access

Application Manager■■ 2545 Binary or 2535/2545/2555

Quaternary gradient modules■■ Fraction Collector III■■ Optimum Bed Density (OBD) Columns■■ Viridis SFC Column chemistries

19

AutoPurification System with the 3100 Mass Detector.

20

[ sfe ]

Waters’ Supercritical Fluid

Extraction (SFE) systems extract

chemical compounds using

supercritical CO2 in place of an

organic solvent. The result is an

extract with little or no residual

solvent, superior purity and

yield, and lower operating

costs compared to traditional

hydrocarbon-based solvent

extraction systems.

SFE is capable of extracting

compounds from solid matrices

to isolate the analyte of

interest, without altering the

taste, aroma, or chemical

composition of your product.

Applications■■ extraction and fractionation

of edible fats and oils■■ Separation of tocopherols

and other antioxidants■■ Detoxification of shellfish■■ Production of flavors,

spice extracts, herbs, dietary supplements

■■ Precision parts cleaning■■ Desolvation within tablets■■ Steroids, polymer/monomer

separation

Key Technologies■■ High pressure CO2 pump■■ High pressure (10,000 PSI)

Finger-tight vessel■■ Automated Back Pressure

Regulator (ABPR)■■ Custom software for easy-

to-use instrument control and data management

21

SFE 1000 System.

The biggest advantage of SFE is that you

can extract your compound with little or

no residual solvent, keeping your product

safe, uncontaminated, and natural.

22

[ QuaNtItat IV e aNd QualItat IV e uPlc /ms ]

For scientists who need to

confidently identify and quantify

unknown compounds in complex

samples, Xevo G2 Tof with UPLC/MSE

and QuanTof Technology offers

exceptional levels of selectivity,

in-spectrum dynamic range, speed

of analysis, quantitative accuracy,

and exact mass performance

simultaneously at unparalleled

levels of sensitivity.

Applications■■ Peptide mapping experiments■■ Intact protein analysis■■ Metabolite identification■■ Discovery DMPK quantitation■■ Food safety screening■■ environmental monitoring■■ exact mass open access analysis■■ Toxicology screening

Key Technologies■■ Waters’ sample preparation solutions■■ ACQUITY UPLC Columns■■ MassPrep™ Peptide and

Protein Standards■■ QuanTof Technology■■ UPLC/MSe

■■ Waters’ Universal Ion Source Architecture

■■ Atmospheric Solids Analysis Probe (ASAP)

■■ Atmospheric Pressure GC (APGC) source

■■ IntelliStart™ Technology■■ MassLynx Software■■ ChromaLynx™, MarkerLynx™,

BiopharmaLynx™, MetaboLynx™ XS, TargetLynx™, and POSI±IVe™ application managers

■■ Biopharmaceutical System Solution with UNIFI

23

ACQUITY UPLC H-Class System with the Xevo G2 Tof.

“ … the capacity for conducting preliminary metabolite identification experiments has increased by almost an order of magnitude, and the turnaround time for metabolism data has been shortened to the point where the information has a much greater impact on decision making.”

Tiller PR, et al.Drug Metabolism, Merck Research LaboratoriesRapid Commun. Mass Spectrom.2008 Apr; 22(7):1053-61.

24

[ QuaNtItat IV e uPlc /ms/ms ]

Xevo TQ and Xevo TQ-S are the

analytical tools of choice for your

most challenging quantitative

UPLC/MS/MS applications,

delivering the ultimate in versatility

for a wide variety of applications –

both quantitative and qualitative.

Xevo TQ-S features a revolutionary

new off-axis ion-source technology,

known as StepWave™. Quantify and

confirm trace components at the

lowest possible levels in the most

complex samples. Both Xevo TQ

and Xevo TQ-S offer ScanWave™

Technology for rapid MRM

acquisition for targeted

quantification – and RADAR™ –

for collection of highly specific

quantitative data for target

compounds and visualization of

all other components in sample

matrices. With Xevo TQ and

Xevo TQ-S, you will develop

methods that bring drugs to market

faster, identify a broader array

of food contaminants, and

report reliable forensic data

with complete confidence.

Applications■■ environmental and food

safety analysis■■ Pharmaceutical discovery

and development■■ Quantitative bioanalysis■■ Clinical assays■■ Metabolite screening

Key Technologies■■ ACQUITY UPLC System■■ ACQUITY Columns■■ MassPrep Peptide and

Protein Standards■■ TQ Detector, Xevo TQ,

and Xevo TQ-S■■ IntelliStart Technology■■ MassLynx or empower software

(TQ Detector only)■■ TargetLynx, QuanOptimize™,

OpenQuan™, ChromaLynx, and MetaboLynx XS application managers

■■ NuGenesis SDMS■■ Atmospheric GC ion source

option for fast swapping between LC and GC applications (Xevo TQ and TQ-S only)

25

ACQUITY UPLC System with the Xevo TQ-S.

“ A fast and simple UPLC/MS/MS method involving… very fast switching of the polarity of ionization allows simultaneous determination of compounds that are amenable to analysis as positive and negative ions. Furthermore, the rapid voltage stabilization in the electronics and detection system… following switches of polarity, ensured that very short inter-channel delays could be used minimizing losses in response. The high resolution capacity of the UPLC method combined with the extremely short analysis times… offers significant benefit for this type of analysis…”

Leandro C.C., et al.Central Science Laboratory, University of YorkJ Chromatogr A.2007 Mar 16;1144(2):161-9.

26 See the Xevo G2 QTof video at www.waters.com/XEVO

[ eXact mass uPlc ms/ms ]

Xevo G2 QTof with UPLC/MSE

and QuanTof Technology offers

unparalleled sensitivity with

exceptional levels of selectivity,

in-spectrum dynamic range, speed

of analysis, quantitative accuracy,

and exact mass performance

simultaneously, for any UPLC/MS,

MSE or MS/MS experiment.

Xevo G2 QTof delivers UPLC/MSE –

a simple, patented method of data

acquisition that comprehensively

catalogs complex samples in a

single analysis. It also provides

UPLC/FastDDA: rapid, automated,

intelligent exact-mass MS/MS for

full structural characterization

and isobaric labeling quantitative

proteomics experiments.

Applications■■ Biopharmaceutical characterization■■ Metabolite profiling■■ Forensic toxicology■■ Food analysis■■ environmental research■■ Chemical industry research■■ Proteomics studies

Key Technologies■■ Waters’ sample preparation solutions■■ ACQUITY UPLC ■■ ACQUITY UPLC Columns■■ QuanTof Technology■■ UPLC/MSe

■■ Waters’ Universal Ion Source Architecture

■■ Atmospheric Solids Analysis Probe (ASAP)

■■ Atmospheric Pressure GC (APGC) source

■■ IntelliStart Technology■■ MassLynx Software■■ ProteinLynx Global Server™,

POSI+IVe, MarkerLynx, TargetLynx, BiopharmaLynx, ChromaLynx, and MetaboLynx application managers

27

“ The completeness of the UPLC/QTof MSe data set is impressive. You can’t fully appreciate it until you’ve solved a major problem with it. We simply didn’t have access to these kinds of results before.”

Johnson D.Director of DMPK, MicroConstants

ACQUITY UPLC System with the Xevo G2 QTof MS System.

28

[ eXact mass uPlc /maldI ms/ms ]

The SYNAPT® G2 MS is our second

generation quadrupole, oa-Tof MS

platform. Incorporating Waters

innovative QuanTof technology, it is

designed to provide a new dimension

in high-resolution exact mass MS and

MS/MS and quantitative performance

in a timeframe compatible with UPLC

separations. Central to its design is

Engineered Simplicity™, so while it is

engineered to handle your most complex

applications, it is also engineered to

add simplicity throughout your entire

workflow. SYNAPT G2 MS is the only

application-specific system solution

with the versatility to give you complete

sample coverage, without compromise

in performance, to meet your laboratory

requirements today and the freedom

to upgrade to the innovative HDMS

capabilities in the future.

The MALDI SYNAPT™ G2 MS System

combines the speed and simplicity

of MALDI with the power of QuanTof

Technology to deliver the very best

sensitivity, selectivity, and specificity

for your discovery research challenges.

Applications■■ Proteomics and biomarker discovery■■ Small molecule analysis■■ Peptide mapping and intact

protein analysis■■ Biopharmaceutical and

protein characterization■■ Tissue imaging■■ Polymer and petrochemical analysis■■ Fine chemicals■■ Lipidomics■■ Food safety and analysis

Key Technologies■■ QuanTof Technology■■ MSe ‘data independent’ acquisition■■ Collision induced dissociation and

electron transfer dissociation■■ IntelliStart Technology■■ Multiple ionization techniques:

eSI, APCI, APPI, MALDI, Atmospheric Solids Analysis Probe (ASAP), Atmospheric Pressure GC (APGC), and TRIZAIC UPLC nanoTile

■■ MassLynx Software■■ BiopharmaLynx, MarkerLynx XS,

ProteinLynx Global SeRVeR, MetaboLynx XS, ChromaLynx, and TargetLynx application managers

■■ i-FIT™ isotope correlation, and MassFragment™ structural assignment

29

SYNAPT G2 MS System.

“ In terms of efficiency for metabolite identification studies, the accurate mass LC/MSe approach has provided significant gains… Typical savings using the approach outlined in this paper have been in the range of 13 hours per molecule. As a result the capacity for conducting preliminary metabolite identification experiments has increased by almost an order of magnitude.”

Tiller PR, et al.Drug Metabolism,Merck Research Laboratories Rapid Commun. Mass Spectrom. 2008 Apr; 22(7):1053-61.

30 Learn more at www.waters.com/SYNAPT

[ uPlc /maldI Ims-ms ]

The second-generation SYNAPT G2

High Definition™ (HDMS) System

combines enhanced high-efficiency

ion mobility separation power

with high resolution tandem mass

spectrometry to deliver new

levels of specificity and sample

definition, enabling researchers

to differentiate samples by size,

shape, charge, and mass.

The MALDI SYNAPT G2 HDMS

System combines the speed and

simplicity of MALDI with ion

mobility-based separations and

high-resolution mass spectrometry

to deliver enhanced specificity

for the analysis of the most

complex mixtures and challenging

discovery applications.

Applications■■ Structural biology■■ Proteomics and biomarker discovery■■ Small molecule analysis■■ High Definition Imaging (HDI™) MALDI■■ Polymer analysis■■ Biopharmaceutical characterization■■ Fine chemicals■■ Food analysis

Key Technologies■■ SYNAPT G2 HDMS■■ MALDI SYNAPT G2 HDMS■■ Triwave® Technology■■ DriftScope™ Mobility environment

Software v.2.1■■ Multiple ionization techniques:

eSI, eSCi™, APCI, APPI, MALDI,■■ Atmospheric Solids Analysis Probe

(ASAP), Atmospheric Pressure GC (APGC), and TRIZAIC UPLC nanoTile

■■ MassLynx Software■■ BiopharmaLynx, MarkerLynx XS,

ProteinLynx Global SeRVeR, MetaboLynx XS, and TargetLynx application managers

■■ MassFragment structural assignment

31

SYNAPT G2 HDMS System.

“ …imaging IM-MS provides several unique advantages including (1) selective imaging of isobaric species (i.e. lipids versus peptides) or structural/conformational subpopulations of the same species on the basis of IM, (2) separation/rejection of undesirable endogenous chemical noise, (3) reduction of ion suppression effects in the source of the Tof- MS, by temporal IM separation of analytes, and (4) potential utility for nearly simultaneous IM-MS/ MS of all analytes at a particular pixel coordinate.”

McLean J. A., et al.Laboratory for Biological Mass Spectrometry,Texas A&M University J Mass Spectrom. 2007 Aug; 42(8):1099-105.

32

[ uNIV ersal IONIZatION arcHIt ecture ]

When you need to extract the

maximum amount of information

from a diverse range of

compounds, you require the

ultimate in ionization flexibility

and performance.

Waters Universal Ion Source

Architecture enables the widest

range of ionization techniques

to be utilized universally across

a single analytical platform.

Providing the highest performance,

without compromise, the ionization

source options are quick and easy

to interchange.

■■ ESI/APCI/ESCi: For the analysis of polar and semi-polar analytes, when coupled with the ACQUITY UPLC System.

■■ APPI/APCI: For the analysis of semi-polar and non-polar analytes when coupled with ACQUITY UPLC separations.

■■ Atmospheric pressure Solids Analysis Probe (ASAP): For the rapid analysis of volatile and semi-volatile solid and liquid samples using atmospheric pressure ionization.

■■ Atmospheric Pressure GC: enables rapid switching from LC/MS/MS to GC/MS/MS applications on a single instrument platform. For the analysis of volatile and semi-volatile compounds of low and intermediate polarity.

■■ MALDI: For the analysis and imaging of biomolecules and synthetic polymers.

■■ NanoFlow™ ESI: For the analysis of minute sample amounts when coupled with the nanoACQUITY UPLC System.

■■ TRIZAIC UPLC nanoTile Technology: Uses micro-fabricated nanofluidic UPLC separations, it utilizes sub-2-μm particle chemistries to provide the very best chromatographic performance simply and without compromise.

33

APGC – Atmospheric PressureGas Chromatography Source.

“ The chromatographic resolution and sensitivity of this novel GC/MS instrument [APGC] surpassed all expectations… every molecule we have thrown at the APGC ion source has responded well and the flexibility for optimizing the signal of choice has opened up a whole new avenue of opportunity for research.”

Mosely J.Senior Research Officer,Department of Chemistry, Durham University

34

[ eXact mass Gc /ms ]

Exact mass measurements allow

compounds to be identified and

confirmed with a greater degree

of confidence than traditional

low-resolution MS techniques. The

GCT Premier™ Mass Spectrometer

brings the specificity of exact mass

measurement to GC/MS analyses.

Isotope prediction/filtering

software, exact mass library

scoring, and a range of application

specific software solutions

maximize the potential of the

data and allow you to rapidly

get to the right answers.

Applications■■ Flavor and fragrance analysis■■ Metabolomic studies■■ Food safety screening■■ Unknown contaminant monitoring■■ Impurity profiling■■ Natural products and

pharmaceutical research

Key Technologies■■ GCT Premier Mass Spectrometer■■ MassLynx Software, i-FIT, and

exact mass library scoring■■ ChromaLynx, MarkerLynx, and

MetaboLynx application managers

35

G CT Premier Mass Spectrometer.

“ The use of DRe improved mass accuracy across the tested concentration range, thus enhancing detection and quantification at higher analyte concentrations. The [GCT Premier] also provided an improvement in selectivity for the pesticides by narrowing the m/z window, giving better separation of the target compounds from coeluting compounds, which is very important when analyzing complex matrices. …The targeted approach with TargetLynx is essential for successful identification and confirmation of the analytes and ChromaLynx is a valuable tool for additional analysis, enabling untargeted analytes to be recognized.”

Leandro C. C., et al.Central Science Laboratory, University of York J Chromatogr A. 2007 Sep 28;1166(1-2):152-62.

36

[ QuaNtItat IV e Gc /ms aNd Gc /ms/ms ]

Extend your MS/MS application

coverage with the Quattro micro™ GC

System for superior quantitative

analysis of volatile and less polar

samples. You’ll benefit from a

range of ionization capabilities and

introduction techniques as well as

the high sensitivity and specificity

of GC/MS/MS. This ensures the most

comprehensive quantitative analysis

of compound extracts.

For the most demanding

environmental and trace GC/MS

quantitative assays, the AutoSpec™

magnetic sector GC/MS offers high-

resolution MS, unrivalled dynamic

range, and customizable regulatory

compliant reporting.

Applications■■ environmental analysis■■ Toxicology screening■■ Food and beverage analysis

Key Technologies■■ Quattro micro GC System■■ Dedicated eI and CI+/CI- sources■■ Sample introduction with GC or DIP

and DCI probes■■ TargetLynx Application Manager for

confirmatory quantitation and reporting

37

Quattro micro GC System.

“ Analyses were performed by gas chromatography with tandem mass spectrometry (MS/MS) in electron impact mode …The excellent selectivity and sensitivity reached in selected reaction monitoring mode allowed us satisfactory quantification and confirmation at levels as low as 25 ng L-1…Analytical methodology using negative chemical ionization mode was also validated for the organochlorine compounds selected, showing a superior sensitivity and lower detection limits.”

Pitarch E., et al.Research Institute for Pesticides and Water, University Jaume I Anal Chim Acta. 2007 Feb 5;583(2):246-58.

38

[ HPlc aNd sfc cOlumN sOlutIONs ]

Waters is committed to advancing

materials science with our continued

development of ground-breaking

HPLC column technologies designed

to address the scientific and business

challenges of our customers.

XSelect Columns

XSelect™ HPLC Columns redefine the definition of a broadly selective modern HPLC column family. Carefully chosen ligands (C18, Phenyl-Hexyl, Fluoro-Phenyl) combined with proprietary Charged Surface Hybrid (CSH) Technology provide chromatographers with uniquely selective columns that deliver high analyte loading, operational stability, and full scalability from UPLC, HPLC, and preparative formats.

XBridge Columns

Possessing unmatched versatility and performance, XBridge™ Columns are the benchmark for LC method development. With superior pH stability over the widest range (1-12), high efficiencies and symmetrical peak shape, XBridge column chemistries (C18, C8, Phenyl, Shield RP18, HILIC, and Amide) can be utilized to address challenging separations. Based upon BeH particle technology present in ACQUITY UPLC BeH Columns, XBridge Columns offer seamless method migration between HPLC and UPLC.

Atlantis Columns

Atlantis HILIC Columns provide an attractive alternative separation to reversed-phase that utilizes high organic HILIC mobile phases to provide increased sample throughput and improved mass spectrometry response, in addition to exceptional polar compound retention.

39

High Strength Silica (HSS) HPLC Columns

Waters developed HSS HPLC columns in response to the active feedback from our customers who have developed UPLC assays, yet require the need to transfer UPLC methods to HPLC. This is necessary in efforts to utilize existing LC systems present in other parts of an organization, or contract partners, which have not yet implemented UPLC Technology. Present in three chemistries (C18, C18 SB, and T3), and two HPLC particle sizes (3.5 and 5 μm), HSS HPLC columns enable methods to be seamlessly transferred between HPLC and UPLC systems.

Viridis SFC Columns

Designed to support the new ACQUITY UPSFC system, four new 1.7 µm SFC column chemistries based on patented ethylene-Bridged Hybrid (BeH) particle technology were developed. New Viridis SFC chemistries include 2-ethylpyridine, 4-ethylpyridine, Fluoro-Phenyl, and unbonded BeH offer excellent peak shape and wide range of selectivity. Purification scientists can scale up to prep with these same Hybrid chemistries which are also offered in 5 µm and packed with patented Optimum Bed Density (OBD) technology for unmatched column lifetimes.

SunFire Columns

SunFire™ Columns set the performance standard in silica-based HPLC technology. With the state-of-the-art reversed-phase C18 and C8 bonding and endcapping technologies, SunFire Columns provide best peak shape for basic compounds at low pH in addition to excellent low pH stability, high efficiency, and high mass loading capacity. SunFire Prep Columns simplify purification for low pH separations by increasing sample load through greater capacity and achieving longer lifetimes with Waters patented OBD (Optimum Bed Density) Prep Column Technology*. The SunFire Prep Column offering includes C18, C8, and Silica (NP) chemistries.

* US Patent Number 7,399,410 and UK Patent Number GB 2408469

Order your 2010 /2011 Waters Quality Parts,

Chromatography Columns, and Supplies Catalog

at www.waters.com/catalog.

40 www.waters.com/PRIMERS

[ uPlc cOlumN sOlutIONs ]

More and more organizations have realized the benefits of improved

productivity, higher data quality, and lower cost per sample, as

well as faster time-to-market, inherent in assays that utilize UPLC

Technology. For these reasons, Waters continues to develop new

and innovative UPLC column chemistries.

ACQUITY UPLC Columns and VanGuard Pre-Columns

The ACQUITY UPLC Column family continues to evolve and expand, now including five particle substrates [BeH 130Å, BeH 200Å, BeH 300Å, HSS, and CSH] and 14 chemistries which are scalable between HPLC and UPLC particle sizes. Additionally, six application-directed UPLC chemistries for SeC, amino acid analysis, proteins, peptides, oligonucleotides, and glycan analysis are available. With a number of selectivity choices for both small molecule and biopharmaceutical applications, Waters has a UPLC column solution to meet your application needs.

New ACQUITY UPLC CSH (Charged Surface Hybrid) Columns are designed to maximize chromatographic selectivity in method development and are available in C18, Fluoro-Phenyl and Phenyl-Hexyl chemistries. These are just the latest addition to the ACQUITY UPLC Column family, providing complementary selectivity to our existing portfolio.

ACQUITY UPLC BeH Columns (available in C18, C8, Shield RP18, Phenyl, HILIC, Amide, SeC 200Å, 300 Å C18, and 300A C4 chemistries), as well ACQUITY UPLC HSS Columns (available in C18, C18 SB, and T3 chemistries). All of Waters ACQUITY UPLC Columns are the only columns designed, tested, and guaranteed for routine use in applications up to 15,000 psi (1034 bar).

Available in 200 plus combinations of column configurations and chemistries, ACQUITY UPLC Columns combine faster separations with higher resolution by harnessing the full potential of small particles. For UPLC column protection, VanGuard Pre-Columns feature a patent-pending design that efficiently prolongs UPLC Column lifetimes in demanding applications with challenging and variable sample quality.

41

Method Transfer Kits

New Method Transfer Kits are designed to preserve the integrity of a separation as it is transferred between UPLC and HPLC platforms. Based on the concept of maintaining column length (L) to particle size (dp) ratio (L/dp), these kits provide a ACQUITY UPLC Column with an HPLC Column of equivalent selectivity and resolving power. Using the ACQUITY UPLC Columns calculator (which can be downloaded at www.waters.com/myuplc), methods can be fully transferred from HPLC to UPLC or from UPLC to HPLC.

Method Development Kits

With a seemingly endless number of method parameters to try, developing a new chromatographic method can be an overwhelming, and time- consuming experience. Waters Method Development kits consist of several UPLC Columns, encompassing a broad range in selectivity, to accommodate your method development approach and enable methods to be developed efficiently and effectively.

Method Validation Kits

With exceptional batch-to-batch and column-to-column reproducibility, Waters well-established particle and column manufacturing process control provide confidence in the long-term reliability of your analytical method. ACQUITY UPLC Method Validation Kits include three batches of chromatographic media [derived from different base particles] to judge the quality, reliability, and consistency of your chromatographic method.

ACQUITY UPLC Column, VanGuard Pre-Columns, and Method Transfer Kits.

Learn about the techniques and technologies of analytical

sciences. View our Primers at www.waters.com/primers.

42

[ BIOseParatIONs aNd aNalyses sOlutIONs ]

Biomolecule Separation Technologies■■ Peptide Separation Technology Columns

for nano, capillary, analytical, and preparative peptide applications

■■ Protein Separation Technology reversed-phase and ion-exchange columns, as well as new SeC offerings for Waters UPLC SeC Solution, and BioSuite™, SeC, IeX, RP, and HIC Columns for HPLC-based applications

■■ AccQ•Tag™ Ultra chemistry specific for Waters UPLC Amino Acid Analysis Solution, as well as Pico•Tag™ and AccQ•Tag for HPLC based amino acid analyses

■■ Oligonucleotide Separation Technology Columns for the analysis and lab scale isolation of synthetic oligonucleotides and DNA/RNA fragments

■■ Glycan Separation Technology sample preparation columns for UPLC or UPLC/MS analysis of glycoprotein derived glycans

■■ MassPReP™ chemistry consumables and kits for MS and LC/MS applications of peptides, proteins, and other biomolecules

Waters is dedicated to providing

innovative UPLC solutions as well as

traditional HPLC-based offerings for

the separation, analysis, and

characterization of DNA/RNA, amino

acids, peptides, proteins, and glycans.

Beginning with a keen understanding of

today’s biomolecule-related challenges,

Waters chemistry operations scientists

and engineers continuously seek

purposeful innovations that help deliver

impactful solutions in applications

ranging from proteomics and biomarker

discovery through the commercialization

of advanced biopharmaceuticals.

IEX and SEC columns for analytical and purification applications.

43

Harness Waters’ technologies for bioseparations and analyses.

44 Learn more at www.waters.com/OSTRO

[ samPle PreParatION sOlutIONs ]

Waters offers comprehensive solutions for sample

preparation challenges, regardless of your preferred

sample preparation technique.

Oasis SPE Family Products

Combining revolutionary sorbents with innovative hardware, Oasis® products are the preeminent choice in solid-phase extraction. Chosen for their reliable, highly selective performance, Oasis products are used by separation scientists across the globe to solve their most difficult sample preparation challenges. Relying on Oasis’ superior technical performance, researchers are able to achieve unmatched purity, consistency, and quality in their sample preparation methods.

Ostro Sample Preparation Products

A novel solution for the cleanup of phospholipids in plasma and serum. Requiring minimal to no method development and using a simple protocol, this technology can be quickly implemented in order to optimize your laboratory’s workflow. Providing cleaner, more reproducible extracts than competitive phospholipid removal devices or techniques, the Ostro™ 96-well plate allows for more sensitive analyses, increased sample throughput, and reduced instrument downtime.

45

Waters, family of sample preparation solutions.

Waters Certified Vials

Waters vials are certified for cleanliness by HPLC and LC/MS testing. These vials fit ACQUITY UPLC and Alliance HPLC systems and most other autosamplers on the market.

For more information, visit www.waters.com/vialsselector.

Sep-Pak SPE Products

Sep-Pak® cartridges and plates are recognized throughout the world and remain the most referenced solid-phase extraction product for sample preparation. A diverse selection of formats and sorbents make Sep-Pak SPe products ideally suited for all types of samples for GC, HPLC, and UPLC analysis methods.

Sirocco 96-Well Filtration Plates

eliminates time-consuming, extra sample-handling steps traditionally done with classical PPT. Provides efficient sample processing resulting in clear filtrates from small sample volumes. Sirocco™ can be automated to process large numbers of samples efficiently.

Pall Life Sciences Sample and Solvent Filtration Products

Waters offers a range of different membranes for solvent and sample compatibility. Filtration formats include apparatus for filtering solvents, and Acrodisc syringe filters for sample filtering needs.

DisQuE™ Dispersive Sample Preparation (QuEChERS)

Conveniently-packaged centrifuge tubes with pre-weighed sorbents and buffers for multi-residue pesticide analysis in food.

PoraPak Rxn Products for Post Synthesis Cleanup

PoraPak™ Rxn is designed for reaction cleanup in drug discovery. The product comes pre-packed in a range of sizes and is offered in bulk for the scale of reaction needs.

46

[ laBOratOry INfOrmatIcs sOlutIONs ]

“ SDMS and empower address the real need to share data among different scientists. It is clear that they [Waters] are seeing what the industry needs, and they are doing everything they can to deliver it to the customer and support the modern laboratory.”

DeSilva T.CeO, Scimcon

www.waters.com/INFORMATICS

47

With the Waters Laboratory Informatics Suite at the core of your lab, you

bring together all of the information management solutions needed to

compile, analyze, find, and share your data for faster and more effective

decision-making. For an application-specific solution or a complete data

management platform, rely on Waters Laboratory Informatics.

Applications■■ Improve data accessibility

and scientific collaboration■■ Automate and streamline

laboratory workflow■■ Compliance management■■ Data security and traceability■■ Advanced data acquisition

and analysis for chromatography and mass spectrometry

■■ Authoring and reporting of scientific information with an analytical electronic laboratory notebook (eLN)

■■ Automatic information capture, cataloging, and archiving from all data sources

Key Technologies■■ NuGenesis Scientific Data

Management System (SDMS) and SDMS Vision Publisher™

■■ empower Chromatography Data Software (CDS), Method Validation Manager, and enterprise Data Manager

■■ MassLynx Mass Spectrometry Software and Application Managers

■■ Fusion Method Development Software from S-Matrix®

■■ UNIFI Scientific Information System, available as part of a complete application-based system solution

Waters Laboratory Informatics solutions convert

the scientific data generated in your lab into valuable

information throughout your organization.

48

[ GlOBal serVIces ]

“ We put more demands on the Waters Service team than most companies. We completed one recent project by working 34 days straight, 24 hours a day. With the help of Waters, we actually delivered the compound a week early.”

Mannerino F.Director of Chromatography and Separation Services,Regis Technologies

49

Be Assured. Choose Waters Global Services.

Waters Global Services focuses on optimizing Waters products with superior service,

support, upgrades, training, and Waters Quality Parts®.

Only the Waters Service team has the most in-depth and up-to-date knowledge of the

advanced science and technologies that provide the foundation for Waters systems. This

enables Waters to help you maximize system uptime, increase laboratory productivity,

and meet stringent compliance requirements.

With 94 offices in more than 50 countries, Waters maintains a strong global presence.

Whether your company is a single-location lab or a large multinational organization,

Waters Global Services provides you with the expertise and responsiveness you need.

Services and Products■■ Instrument and software

support plans■■ Automated qualification

for Waters and Agilent Systems

■■ Instrument and software upgrades

■■ empower Driven Services

■■ Performance Maintenance

■■ education and training

■■ Application and technical support

■■ Remote monitoring and diagnostics

■■ Waters Quality Parts■■ Relocation Services■■ Asset Management

Choose Waters for Proven Satisfaction

For nine consecutive years, an independent quality auditing firm ranked

Waters Global Services best-in-class in providing expert technical knowledge,

quick resolution of system issues, and process support.

50

Waters Centers of Innovation Program recognizes analytical

scientists facilitating breakthroughs in health and life science

research, food safety, environmental protection, sports

medicine and many other areas.

Professor David Cowan Forensic Science and Drug Monitoring Director, Drug Control Centre King’s College London

Under the direction of Professor

David Cowan, King’s College London

Drug Control Centre will be responsible

for drug testing all athletes at the 2012

Olympic Games. That translates into

5,000 to 6,000 samples in two weeks,

with results back in 24 hours.

To hear more of what our customers are saying,

go to www.waters.com/customers.

Dr. Julie Leary Professor University of California-Davis

Professor Leary’s use of mass

spectrometry to study biological and

chemical systems, particularly how

certain bacteria and viruses affect

host organisms, has advanced the

scientific community’s understanding

of infectious diseases.

51

Professor Julie Leary

Professor David Cowan

Dr. Jeremy Nicholson Chair in Biological Chemistry Department of Surgery and Imperial College

Professor Nicholson was one of the

first to embrace the importance of

metabolic profiling, and is now Head

of one of the largest clinical academic

departments in the world.

Dr. John Engen Associate Professor of Chemistry and Chemical Biology The Barnett Institute Northeastern University

A pioneer in the combined use of

hydrogen-deuterium exchange (HDX)

technology, UPLC and ion mobility

mass spectrometry, Dr. Engen is a

leading expert on understanding

proteins and protein confirmation, more

specifically on how chemically active

sites on a protein structure are affected

by conformation and the impact that

this might have on disease.

[ aP PlIcat ION sOlutIONs ]

Biopharmaceutical

■■ Amino acids■■ Peptides■■ Vaccines■■ Oligonucleotides■■ Intact proteins■■ Carbohydrates

Clinical Solutions

■■ Neonatal screening■■ Endocrinology■■ Amino acid analysis■■ Tacrolimus monitoring■■ Immunosuppressant

monitoring■■ Toxicology screening■■ Drugs of abuse

Environmental

■■ Drinking water testing■■ Wastewater testing■■ Soil testing■■ Biosolid analysis■■ Air monitoring■■ Emerging contaminants■■ EPA methods

Fine and Specialty Chemicals

■■ Structural elucidation■■ Sample profiling■■ Impurity

identification■■ Structural

confirmation■■ Method development■■ In-process monitoring

52

53 54

Food Profiling

■■ Detect adulteration■■ Assure authenticity■■ Confirm origin

Food QC and Nutritional Testing

■■ Raw material■■ Consistency■■ In-process monitoring■■ Final product quality■■ Verifying composition

and label claims■■ Amino acid analysis

in food and feed

Food Safety

■■ Pesticides■■ Veterinary drug

residues■■ Mycotoxins■■ Marine biotoxins■■ Processing

contaminants

Forensics

■■ Drugs of abuse■■ Toxicology

Polymers

■■ Polymer additives■■ Starch■■ Molecular weight

distributions

Proteomics

■■ Characterization■■ Quantification■■ Biomarker validation■■ Identification■■ Bioseparations/

interactions

Tissue Imaging

■■ Biomarker discovery■■ Drug/metabolite

distributions

Pharmaceutical

■■ ADME screening■■ Bioanalysis■■ Bioequivalence■■ Compound library

maintenance■■ Dissolution testing■■ Forced degradation■■ Impurity profiling■■ Manufacturing■■ QA/QC■■ Metabolite

identification■■ Lipidomics■■ Metabolomics■■ Method development■■ Method validation■■ Natural products■■ Traditional

medicine analysis■■ Open access

[Product Guide 2011]

SaleS OfficeS:

Austria 43 1 877 18 07

Australia 61 2 9933 1777

Belgium and Luxembourg 32 2 726 1000

Brazil 55 11 4134 3788

Canada 1 800 252 4752

China 86 21 6156 2666

Czech Republic 420 2 617 11384

Denmark 45 46 59 8080

Finland 358 9 5659 6288

France 33 1 30 48 72 00

Germany 49 6196 400 600

Hong Kong 852 2964 1800

Hungary 36 1 350 5086

India 91 80 2837 1900

Ireland 353 1 448 1500

Italy 39 02 265 0983

Japan 81 3 3471 7191

Korea 82 2 6300 4800

Mexico 52 55 52 00 1860

The Netherlands 31 76 508 7200

Norway 47 6 384 6050

Poland 48 22 833 4400

Puerto Rico 1 787 747 8445

Russia/CIS 495 727 4490 / 290 9737

Singapore 65 6593 7100

Spain 34 93 600 9300

Sweden 46 8 555 115 00

Switzerland 41 56 676 7000

Taiwan 886 2 2501 9928

UK 44 208 238 6100

US 1 800 252 4752

ACQUITY, ACQUITY UPLC, Alliance, Atlantis, AutoPurification, AutoSpec, Connections INSIGHT, ESCi, GCT Premier, nanoACQUITY UPLC, NuGenesis, Oasis, PATROL, Pico•Tag, Sep-Pak, StepWave, Symbiosis, Symmetry, SYNAPT, Triwave, UPLC, Waters, Waters Quality Parts, and Xevo are registered trademarks of Waters Corporation. AccQ•Tag, Auto•Blend, Auto•Blend Plus, AutoSpec, BiopharmaLynx, BioSuite, Breeze, ChromaLynx, CSH, DisQuE, DriftScope, E High Definition Proteomics, Empower, Engineered Simplicity, Expression, FractionLynx, HDI, HDMS, High Definition MS, i-FIT, IntelliStart, MALDI SYNAPT, MarkerLynx, MassFragment, MassLynx, MassPREP, MetaboLynx, OBD, OpenLynx, OpenQuan, Ostro, PoraPak, POSI+IVE, ProteinLynx Global SERVER, QuanOptimize, Quattro micro, Quattro Premier, RADAR, Real-TIME LC, ScanWave, SDMS Vision Publisher, Sirocco, SunFire, TargetLynx, TRIZAIC nanoTile, TRIZAIC UPLC, UNIFI, UPSFC, VanGuard, Viridis, XBridge, and XSelect, and T he Science of What’s Possible, are trademarks of Waters Corporation. S-Matrix and Fusion are trademarks of S-Matrix Corporation. All other trademarks are the property of their respective owners.

©2011 Waters Corporation. Printed in the U.S.A. March 2011 720002048EN LL-CP

Waters Corporation 34 Maple StreetMilford, MA 01757 U.S.A.T: 508 478 2000F: 508 872 1990www.waters.com

Designed by scientists for scientists, Waters solutions remove the guesswork in choosing the best way to achieve your application’s goals.

Whether you work in pharmaceuticals, biopharmaceuticals, environmental,

food testing, clinical, or beyond, with Waters application focused solutions,

you can be assured that whenever a new analytical challenge arises,

Waters will have the technology and expertise to help you conquer it.

These solutions provide a comprehensive approach to address analytical

lab needs that include instrumentation, columns and sample prep,

software, and support services.

sales offices : austria designed by scientists for ... · 4 biopharmaceutical system solution with...

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