sagecite demonstrator overview
DESCRIPTION
A description of the demonTRANSCRIPT
SageCite workflow citation demonstrator
Peter Li
Workflows
• Two workflows have been developed with Brig Mecham from Sage Bionetworks
MetaGEO project
• The 2 workflows have been developed in the context of Brig’s MetaGEO project which normalises gene expression data sets in the GEO database
• The normalised data sets enable meta-analyses, e.g. identification of disease signatures
• Difference between MetaGEO and other similar projects is that all research objects in MetaGEO is open access– Data, results, intermediate results, data analysis and integration
procedures, etc• Enhances the trust of MetaGEO data by researchers• For more information on MetaGEO, see Brig’s slides on
SageCite wiki
Anders Rosengren, Diabetes & Perturbations
Lilyana Margaretha, Stem Cell BiologyPete Nelson, Prostate CancerBin Zhang, AMLJoyoti Dey, MedulloblastomaMette Peters, Alzheimers
metaGEO: Current Users/Contributors
Roel Verhaak, Updated GSE6891
Ji Zhang, AML
Peter Li, Workflows
Brig Mecham, Sage Bionetworks
metaGEO: Automated Workflows
(2) Curation (3) QC (4) Inference
(1) Acquire Data
Brig Mecham, Sage Bionetworks
Workflow 1
• This workflow produces an annotation library that is used to map gene probes on Affymetrix chips to a specific gene for an organism
• The library is used as part of the curation step for gene expression data sets in GEO
Workflow 2
• This workflow performs normalisation and inference analysis on GEO data
• Produces normalised data and statistics of gene expression
Workflow citation demonstrator
• Developed a Taverna plugin for registering workflow results with a DOI using DataCite service
Workflow citation demonstrator
• Plugin provides an operation in Taverna’s service palette that can be incorporated into workflows to register a data set with a DOI via DataCite
Registration of data
• To register data, the plugin provides it with a DOI
• For example:– 10.5520/SAGECITE-1
SageCite demo repository web site• The plugin stores data in a local sqlite database and creates a
web page on the SageCite demo repository web site to display data
Registration of data using DataCite
• The plugin uses the DOI to register the data on DataCite using its Web API
Clicking on the DOI link takes you to the web page for the data on the SageCite demo repository site
Registration of data using DataCite
To do and issues
• Need to register metadata for workflow results using DataCite API
• Large size of data generated from Brig’s pipelines sometimes breaks plugin