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1. Homocystinuria is one of the few diseases that can result in subluxation of the lens. What are the different causes of homocystinuria? How does the treatment differ for each? (FA13 p109) (FA14 p111) (SU14 p306)

2. Diagram the pathway by which the cochlea communicates a signal to the primary auditory cortex. (Phys p639)

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3. A 20-year-old Italian woman complains of weakness and fatigue. A CBC reveals a microcytic, hypochromic anemia with a normal iron panel. What type of thalassemia does this patient most likely have? What is the structure of HbH? What disease results in HbH production? What is the structure of Hb Barts? What disease results in Hb Barts production? (FA13 p352-353) (FA14 p382-383) (SU14 p281-282)

4. A 34-year-old obese white woman develops urinary retention after undergoing a laparoscopic cholecystectomy. Which cholinergic agonist can be used to treat post-op ileus and urinary retention? What conditions can be made worse by using cholinomimetic agents? (FA13 p233) (FA14 p246) (SU14 p401)

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5. For what conditions is hyperbaric oxygen therapy particularly helpful? (SU14 p17-18) (Phys p540)

6. A 23-year-old man undergoes a splenectomy due to splenic rupture from blunt abdominal trauma. What would you expect to find on this patients peripheral RBC smear after the splenectomy? (FA13 p351) (FA14 p381) (SU14 p286) Asplenic patients are susceptible to which encapsulated organisms? (FA13 p193) (FA14 p197) (SU14 p282) What vaccines for these encapsulated organisms should be given to asplenic patients? (FA13 p121) (FA14 p123)

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7. If stroke volume determines cardiac output, and contractility determines stroke volume, what determines contractility? (FA13 p254) (FA14 p267) (Phys p231)

8. What is the pressure in the potential spaces of the body including the pleural cavity, the joint spaces, and the pericardial cavity? (Phys p300)

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9. How does standard deviation differ from standard error of the mean? (FA13 p54) (FA14 p56) Which one is used in calculating confidence intervals? (FA13 p55) (FA14 p57)

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10. A 48-year-old man presents to your office with a persistent cough that has begun to become bloody. CXR reveals a coin lesion within the lung parenchyma. Further work up reveals that the patient has the most common type of lung cancer in non-smokers. Which cancer is this? What other lung cancers are not associated with smoking? Which lung cancers are associated with smoking, and where are they located, centrally or peripherally? (FA13 p558) (FA14 p609) (SU14 p116)

*Page references are as follows: FA13: First Aid for the USMLE Step 1 2013 FA14: First Aid for the USMLE Step 1 2014 SU14: Step-Up to USMLE Step 1 2014 R: Robbins and Cotran Pathologic Basis of Disease, 8th ed. (2010) Phys: Guyton and Hall Textbook of Medical Physiology, 12th ed. (2011) H: Harrisons Principles of Internal Medicine, 18th ed. (2012) COA: Clinically Oriented Anatomy, 6th ed. (2010) GG: Goodman and Gilman Pharmacological Basis of Therapeutics, 12th ed. (2011)