s the european up-front risk assessment tool (eufrat) the european up-front risk assessment tool...
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The European Up-Front Risk Assessment Tool
(EUFRAT)
The European Up-Front The European Up-Front Risk Assessment ToolRisk Assessment Tool
(EUFRAT)(EUFRAT)
Presentation overview
1. Dynamics in blood transfusion chain
2. Risk model scheme
3. Outputs of the risk model
4. Modules in the risk assessment tool:– Tool functionality:
• Specification questions• Risk calculator • Options panel
– User manual
Blood transfusion chain
General population
Donors
Infected
Plasma / components
Processingproducts
Final blood
products
Recipient
Probability of infection
Contaminationprobability & amount of infectious material
Risk reduction
Risk of infection
Donor selection / screening
Product risk
Risk Model Scheme
• Entities • Modulating factors (input)
Infected
Outputs of the risk model
Module: Tool functionality
• Specification questions• Risk calculator • Options panel: Additional settings/functions/documentation
Specification questions
Specify the risk to be estimated and the data the users have available.1. Do you want to estimate the risk of transfusion transmission from a donor who
has visited an outbreak-affected region?
2. Is the number of infected donors available?
2.1. Are the infected donors identified by testing the donation?
2.2. Is the test performance (sensitivity & specificity) available?
3. Is information on various donation types and frequencies available?
4. Are there questions in the donor health questionnaire that potentially screen out the infected donors before donation?
5. Is the donated blood screened for the infection using a diagnostic test?
6. Is pathogen removal/inactivation or blood processing implemented to minimize the risk of contamination?
6.1. Is detail of infectivity level available?
Specification questions (continued)
Entities
Questions
Risk calculator
Interface options:•Disease selection•Expand/collapse of five entities•Constant/random variables•Variable info and chart•Editable fields
Risk calculator (continued)
Disease selection:• Select one from the eighteen emerging infections provided in dropdown
menu OR select “Not specified” for calculating other diseases.
Risk calculator (continued)
Expand/collapse: • To show/hide the details of five entities
Collapsed
Expanded
Risk calculator (continued)
Input/output variables:• Constant: point estimate • Random: estimate distributed in a range • Validation text: inputs are valid for calculation
ConstantRandom
Validation text
Risk calculator (continued)
Variable info and chart•Info: help text of the variable.•Chart: provided when the input/output is in range
Info Chart
Risk calculator (continued)
Adjustable inputs• Add or delete • Re-name
Re-name
Add/delete
Options panel: Additional settings/functions/documentation
Simulation:•Generate number of samples•With or without replacement•(Automatic) calculation
Generate samples
(Automatic) calculation
Options panel (continued)
Tool additional functions:•Save inputs and outputs •Load them for reuse, and•Print results
Additional functions
Options panel (continued)
Documentation: • Worked examples of emerging infections outbreaks with their risk
estimates calculated using EUFRAT
Presentation slides: summary of all tool functionalities.
User manual
Contents:• Introduction• Step-by-step guidance• List of definitions• Infection data• Risk model flowchart• Modelling assumptions• Formulas for calculation• List of symbols• Reference list