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Personalized IBD and VEO-IBD: Genomics, Microbiome, Biologics and Beyond

Friday, May 18, 2018

Ruth and Tristram Colket, Jr.

Translational Research Building on

the Raymond G. Perelman Campus

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Course informationThis one-day course is designed to present the latest developments in research and clinical care for very-early-onset inflammatory bowel disease (VEO-IBD) and pediatric IBD. Participants will receive a comprehensive overview of the genomic, immunologic and microbiome discoveries in VEO-IBD and in pediatric IBD and of the advances in the diagnosis, management and therapy of the disease. This will include lectures by nationally and internationally recognized experts and interactive panel discussions.

This activity has been designed for gastroenterologists, gastrointestinal surgeons, GI fellows and residents, physician assistants, clinical nurse specialists, radiologists, pathologists, nutritionists, and other healthcare professionals.

General InformationThe conference will be held in the Ruth and Tristram Colket, Jr. Translational Research Building on the Raymond G. Perelman Campus at Children’s Hospital of Philadelphia. The registration fee for physicians is $75 and the fee for nurses is $50. Residents, fellows and medical students may attend for free, however, they still need to register. This fee includes breakfast, lunch and program material.

All attendees are invited to submit an abstract for poster or oral presentations.

Course Objectives• Review the genetics of VEO-IBD, new candidate genes and the relevance of

these discoveries to disease development

• Review the role of the dysregulated immune system in VEO-IBD and pediatric IBD and how this can impact therapeutic strategies

• Manage difficult cases in VEO-IBD and pediatric IBD

• Practice appropriate therapy for patients with VEO-IBD and pediatric IBD, considering the both the patients phenotype and underlying genetics

• Explain the role for endoscopic intervention in pediatric IBD

• Identify the therapeutic targets in pediatric IBD and outcome measures of success of therapy

• Counsel patients about the role of diet in disease development and as therapy for patients with IBD

• Discuss the current role of fecal microbiome transplant in IBD

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ACCME Accreditation StatementChildren’s Hospital of Philadelphia is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing education for physicians.

AMA Credit Designation StatementChildren’s Hospital of Philadelphia designates this live activity for a maximum of 5.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Hotel AccommodationsA block of rooms has been reserved at reduced rates at the Sheraton University City, located just a few blocks from Children’s Hospital. The group overnight rate is $209 single and double occupancy plus a 15.2 percent room tax. Participants are required to make their own hotel reservations by calling the Sheraton directly at 215-387-8000. Please mention the name of the conference when making your reservation. The special room rate will be available until April 17, 2018. After that date, reservations will be accepted on a space and rate availability basis.

Cancellation and Refund PolicyChildren’s Hospital of Philadelphia reserves the right to cancel or postpone any course due to any unforeseen circumstances. In the event of cancellation or postponement, Children’s Hospital of Philadelphia will refund any registration fees, less a $40 service charge, but is not responsible for any related costs, charges or expenses to participants, including cancellation charges assessed by airlines or travel agencies. In order to process refunds for course withdrawals, cancellation must be received in writing by Friday, May 4, 2018. No refunds will be issued thereafter.

Services for People with Disabilities If special arrangements are required for an individual with a disability to attend this meeting, please contact the Continuing Medical Education Department at 215-590-5263.

Register online at chop.cloud-cme.com

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7:30 a.m. Registration and Continental Breakfast

8:15 a.m. Welcome and Introduction Joseph W. St. Geme, MD Bryan A. Wolf, MD, PhD

VEO-IBDModerator: David A. Piccoli, MD

8:30 a.m. Novel Mechanism of Immune Dysfunction in VEO-IBD Kathleen E. Sullivan, MD, PhD 8:50 a.m. Therapeutic Concepts in VEO-IBD Judith R. Kelsen, MD 9:10 a.m. ITK Haploinsufficiency Leading to a VEO-IBD Syndrome Edward M. Behrens, MD

9:30 a.m. Panel Discussion: VEO-IBD Patient Case

10 a.m. Break

Endoscopic Therapeutic Interventions and Mucosal Targets of DiseaseModerator: Joel Rosh, MD

10:15 a.m. Endoscopic Stricture Therapy: When to Dilate, Inject, or Cut Petar Mamula, MD

10:35 a.m. Defining Remission: Lessons from the PROTECT Study Jeffrey S. Hyams, MD

10:55 a.m. Severe Colitis Andrew B. Grossman, MD

11:15 a.m. Panel: IBD Case

11:45 a.m. Lunch

Program — Friday, May 18, 2018

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1 p.m. Targeted Therapy in IBD Marla C. Dubinsky, MD 1:20 p.m. Therapeutic Drug Monitoring Mark T. Osterman, MD 1:40 p.m. What Is the Target We Are Striving for and What Should We Be Striving for? Robert N. Baldassano, MD

2 p.m. Panel Discussion and Case

2:30 p.m. Coffee/Snack Break

MicrobiomeModerator: Frederic D. Bushman, PhD

3 p.m. Diet and IBD: What Works and What Is the Hype? Lindsey G. Albenberg, DO

3:20 p.m. Fecal Microbiota Transplant: Is There a Role in IBD? Stacy A. Kahn, MD

3:40 p.m. Panel

4 p.m. Adjourn

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Unless otherwise noted, faculty are from Children’s Hospital of Philadelphia and/or the Perelman School of Medicine at the University of Pennsylvania.

Course DirectorsRobert N. Baldassano, MDDirector, Center for Pediatric Inflammatory Bowel DiseaseCo-director, Penn/CHOP Microbiome ProgramProfessor of Pediatrics

Judith R. Kelsen, MDFaculty Physician Director, Very Early Onset IBD CenterAssistant Professor of Pediatrics

Course FacultyLindsey G. Albenberg, DOFaculty PhysicianProgram Director, IBD Fellowship

Edward M. Behrens, MDChief, Division of RheumatologyAssociate Professor of Pediatrics

Andrew B. Grossman, MDFaculty PhysicianCo-director, Center for Pediatric Inflammatory Bowel DiseaseAssociate Professor of Clinical Pediatrics

Petar Mamula, MDFaculty Physician Director, Kohl’s GI Nutrition and Diagnostic Center, endoscopy suiteCo-director, Center for Digestive, Liver and Pancreatic MedicineProfessor of Pediatrics

David A. Piccoli, MDFaculty PhysicianChief, Division of Gastroenterology, Hepatology and NutritionDirector, Fred and Suzanne Biesecker Pediatric Liver CenterFred and Suzanne Biesecker Professor of Pediatrics

Faculty

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Joseph W. St. Geme, MDPhysician-in-ChiefChair, Department of PediatricsProfessor of Pediatrics

Kathleen E. Sullivan, MD, PhDChief, Division of Allergy and ImmunologyProfessor of Pediatrics

Bryan A. Wolf, MD, PhD Chief Scientific OfficerCHOP Research InstituteProfessor of Pathology and Laboratory MedicineProfessor of Pediatrics

Guest FacultyFrederic D. Bushman, PhDChair, Department of MicrobiologyCo-Pl, Penn/CHOP Microbiome ProgramHospital of the University of PennsylvaniaProfessor of Microbiology

Marla C. Dubinsky, MDChief, Pediatric Gastroenterology and HepatologyDirector, IBD Center, Mount Sinai Medical CenterProfessor of PediatricsIcahn School of Medicine at Mount Sinai

Jeffrey S. Hyams, MDDivision Head, GastroenterologyDirector, Inflammatory Bowel Disease CenterConnecticut Children’s Medical CenterProfessor of PediatricsUniversity of Connecticut School of Medicine

Stacy A. Kahn, MDFaculty PhysicianBoston Children’s HospitalAssistant Professor of PediatricsHarvard Medical School

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Mark T. Osterman, MD, MSCEFaculty PhysicianHospital of the University of Pennsylvania andThe Presbyterian Medical Center of PhiladelphiaAssociate Professor of Medicine

Joel Rosh, MDDirector, Pediatric GastroenterologyVice Chairman, Clinical Development and Research AffairsGoryeb Children’s Hospital/Atlantic Health SystemMount Sinai HospitalProfessor of PediatricsIcahn School of Medicine

©2018 The Children’s Hospital of Philadelphia • 18CME0211/WEB/04-18