Curriculum Vitae Ryan D. Russell, Ph.D.

BUSINESS ADDRESS Menzies Institute for Medical Research Muscle Metabolism and Diabetes Research Group 23, Hobart TAS 7000 RyanRussellPhD@gmail.com R.Russell@utas.edu.au www.facebook.com/MenziesFit

EDUCATION 2002 B.S. Major: Biomedical Science; Minor: English Literature, Marquette

University, Milwaukee, WI 2011 Ph.D. Kinesiology, Louisiana State University, Baton Rouge, LA

Thesis: An Examination of Metabolism in Diabetic Offspring Committee Members: Arnold Nelson, Ph.D. (Chair) Robert R Kraemer, Ed.D. Jan Hondzinski, Ph.D. T. Gilmour Reeve, Ph.D. Matthew Hulver, Ph.D.

APPOINTMENTS POST-GRADUATE TRAINING Sept 2014 – Present

2014 ACSM Visiting Scholar and Junior Research Fellow, Menzies Institute for Medical Research, Muscle Metabolism and Diabetes Research Group

• Coordinate and run multiple patient-oriented clinical trials and exercise interventions aimed at improving microvascular blood flow and symptoms of type 2 diabetes.

• Extensive experience in grant-writing, contrast-enhanced ultrasound (CEU) with microbubbles, Laser-Dopper flow, manuscript writing, Mobile-O-Graph PWA, indirect calorimetry.

Sept 2013 – Aug 2014 Postdoctoral Fellow, UCLA School of Nursing

Large-scale, NIH-funded patient-oriented resistance-training intervention (Get Fit Study) • Limited experience in endothelial progenitor cell (EPC) principals and applications, brachial artery flow-

mediated dilation testing and analysis, pulse wave analysis (PWA) and pulse wave velocity (PWV) testing and analysis.

• Experience in Cell-signaling and molecular aspects of oxidized HDL-stimulated ET-1 synthesis and secretion, primary endothelial cell project: dose-response of nicotine on ROS production in EC, ELISA, Western Blot, and other previously acquired basic science techniques.

• Extensive experience in Continuous 24-hour glucose monitoring systems (CGMS), oxygen kinetics and metabolic flexibility during and after exercise, large database design and management.

August 2011 – August 2013

NIH/NHLBI T32 HL072751-07 Training Grant in Cardiac and Vascular Cell Biology, University of Maryland, School of Medicine • Training in molecular and cellular biology under guidance of Michael Quon and Xiao Jian Sun. • Limited experience in mouse/rodent (mouse and rat) handling, GTT, injections, euthanizing, etc.

• Experience in Q RT-PCR, Real Time PCR, microscopy, Transformations, primer design, RNA isolation, grant- writing, scrambled/siRNA, and molecular biology techniques.

• Extensive experience in: Western Blot, cell culture, transient transfections, mini and maxi-prep, experimental cell-culture design, luciferase testing, cell freezing and thawing, cDNA preparation, DNA cutting, RNA, DNA and protein concentration using nano-drop, making agarose and acrylamide gels for DNA testing and Western Blot and subsequent analysis, making basic lab solutions for routine use, and general cellular techniques including various cell lines and primary endothelial cells.

April 2011- May 2011

Visiting Scholar, Virginia Tech • Experience in Nano-dropping, DNA, RNA and protein Isolations, RT-PCR and Western Blots, and

assisted in animal procedures/care under Matthew Hulver. DOCTORAL AND PRE-DOCTORAL Sept 2010- Dec 2010

Visiting Scholar, M3 Lab, Maastricht University, Netherlands • Continuous 24 hour glucose monitoring system (CGMS) under Prof. Luc van Loon • Compared GlucoDay with MiniMed CGMS systems • Compared CGMS changes with varying exercise frequency and duration • Training in Metabolic Flexibility assessment, and study design • Accessioning and snap-freezing plasma

June-July 2010 Lab Volunteer, Pennington Biomedical Research Center (PBRC), Clinical and Accessioning. • Shadowed and observed laboratory methods in Accessioning and Clinical Chemistry laboratories of the

PBRC.

2009-2011 PhD Student, Department of Kinesiology, Louisiana State University • Coordinated resting metabolism and oxidative stress study in diabetics, diabetic offspring, and healthy

controls • Quantified RMR, RER and metabolic flexibility in relation to fasting, stretching, and during OGTT

Examined blood/plasma markers of oxidative stress in diabetics, diabetic offspring and controls; established a metabolic profile for diabetic offspring vs those with no history of diabetes.

• Classes taught to undergraduates: Anatomy lab (computer based), Exercise physiology lab (hands on), circuit and resistance training (hands on).

2004-2009

Research Associate, Department of Kinesiology, Louisiana State University • Conducted Continuous Scale Physical Function and Performance (CSPFP-10) tests at Leo S Butler

Center, Saint James Place, and Pennington Biomedical Research Center. • Utilized K-4 portable metabolic testing unit in various elderly populations at Saint James Place, Leo S

Butler Center, and Pennington Biomedical Research Center for Continuous Scale Physical Function and Performance (CSPFP-10) and treadmill tests.

• Conducted ultra-high resolution ultrasound for assessing brachial artery indices in young athletes, obese volunteers, and elderly research participants (age 18-102)

• Analyzed ultrasound images with specialized semi-automated edge-detecting software.

2002-2004

Research Associate, Pennington Biomedical Research Center (PBRC) • Performed MRS analysis in muscle and liver. • Conducted research and development activities to augment knowledge of mechanisms of obesity and age

related illnesses. • Evaluated and analyzed clinical research data. Utilized computer networking to do research with

individual’s offsite. • Conducted exercise testing (VO2max tests, stress tests, YMCA Bike tests, Cybex tests, endurance

performance tests, pulmonary function, and 12-Lead EKG), assigned exercise prescriptions for participants, scheduling, scientific paper writing, and research in Pennington’s Fitness Center.

• Supervised an exercise lab at LSU for a new Wellness Program. • Used IDEEA from MiniSun to monitor participant’s activities, and train researchers on how to use this

accelerometer. • Performed all MRI muscle analysis for PBRC. • Compared energy expenditure from both doubly labeled water and accelerometers from the CALERIE

study. • Communicated findings through reports and publications, monitor and report on progress of ongoing

clinical studies. Recruited and screened research patients. Conducted patient interviews to evaluate patient eligibility for studies coordinated.

• Managed large databases for data collected from studies, and delegated tasks to others. HONORS AND AWARDS

Christian Brothers University Cross Country Letterman. 1997 – 1998 Marquette University Men’s Lightweight Crew Team Letterman. 2000 – 2001 Louisiana State University, Dept. of Kinesiology, Lillian Olsen scholarship recipient. 2006 – 2010 Louisiana State University, Dept. of Kinesiology, National Institute on Aging (P01 AG022064) research fellowship (Louisiana Healthy Aging Study). 2004 – 2009 Louisiana State University, Dept. of Kinesiology PhD Program, Board of Supervisors Scholarship. 2010 – 2011 Louisiana State University, Dept. of Kinesiology, Lifestyle and Aging research endowment. 2005 – 2010 American College of Sports Medicine 2014 Visiting Scholar Award. 2014 – 2015

EXTRAMURAL GRANT SUPPORT ACTIVE 1) American College of Sports Medicine (ACSM) Visiting Scholar Award:

Microvascular-linked Metabolic Flexibility in Adult Offspring of Type-2 Diabetics. Menzies Research Institute, Tasmania, Australia.

Purpose: Gain cutting-edge, highly sought-after vascular and cardiac imaging skills, Trained by Drs. Marwick, Rattigan, Sharman, and Keske. September 2014 – May 2015 PI $5,000

2) virtual Tasmanian Academic Health Science Precinct (vTAHSP) Grant. Cardiometabolic benefits of exercise training in type 2 diabetics independent of weight loss. Sept. 2014 – May 2015 Co-Investigator $50,734

3) Royal Hobart Hospital (RHH) Research Foundation Grant Pilot Grant: Microvascular dysfunction in adult offspring of type 2 diabetics Menzies Research Institute; Royal Hobart Hospital, Tasmania, Australia. August 2014 – July 2015 Co-Investigator $20,294

4) Menzies Research Institute Tasmania top-up funds. 2014 – 2015 Co-Investigator $35,000

COMPLETED 1) NIH/NHLBI T32 HL072751-07 Training Grant in Cardiac and Vascular

Cell Biology, 2011 - 2013 $102,000

2) NIMHD Health Disparities, NIH-Loan Repayment Program (LRP) recipient. 2012 - 2014 $43,000

PENDING

1) National Health and Medical Research Council (NHMRC) Preventing T2D by Targeting Microvascular Blood Flow in Offspring of T2D patients. Scope: Utilize resistance exercise and traditional pharmaceutical therapies to target

microvascular blood flow in at-risk populations. Jan 2016 – Dec 2020 Co-I $1,570,000 2) Cancer Australia. Novel Therapy to Improve Smoking Cessation, Weight Maintenance, and Cardiometabolic Health. Scope: To improve smoking cessation and decrease cancer risk profiles by

using resistance training in combination with NRT. Jan 2016 – Dec 2018 CI-A (PI) $505,540 3) Diabetes Australia

Cardiometabolic response of exercise in overweight/obese patients with type 2 diabetes & pre-diabetes Scope: Identify early CMS markers of T2D in response to exercise training in people with T2D. Jan 2016 – Dec 2016 Co-I $60,000

PROFESSIONAL SOCIETIES The American College of Sports Medicine (2004 – present) Mid-Atlantic Regional Conference- American College of Sports Medicine (2012 – 2014) American Diabetes Association (2012 – present) American Heart Association (2013 – present) TEACHING SERVICE Louisiana State University Sept 2004- July 2010

Guest Lecturer: Exercise Physiology Presented guest lectures on cardiovascular function, VO2, metabolic function and cardiometabolic syndrome. Incorporated the STAR (Science Teacher And Researcher) teaching techniques, with heavy emphasis on student interactions and responses. Guest Lecturer: Exercise in Health and Disease lectures Presented guest lectures on exercise in response to diabetes and cardiovascular disease, as well as exercise prescription in aging populations. Incorporated the STAR (Science Teacher And Researcher) teaching techniques, with heavy emphasis on student interactions and responses. Exercise Physiology Lab Lectured prior to each lab discussing the practical and physiologic applications of each set of tests. Taught principals of testing, and testing methods for various clinical exercise physiology tests, including VO2 max, cycle ergometer, plyometric jump, etc. Anatomy Lab Taught computer-based interactive human anatomy using A.D.A.M. dissectible interactive software. Created and graded online teaching and testing for anatomy using Blackboard. Tutor for the LSU Center for Student-Athletes Lead group tutoring session, as well as one-on-one tutoring for LSU student athletes in various Kinesiology-related courses. Mentored two junior graduate students in both cardiovascular disease research, and etiology and progression of diabetes and lipotoxicity. Both of whom are now tenure-track faculty at graduate institutions.

2015 – University of Tasmania

Coordinate 2 units (Genetics and Epidemiology) at the University of Tasmania. Responsibilities include course development, syllabus design, coordination of lecture rooms and various lecturers, and grading.

PEER-REVIEWED PUBLICATIONS 1) Russell, R.D., Redmann, S.M., Ravussin, E., Hunter, G.R., Larson-Meyer, D.E.: Reproducibility of

endurance performance on a treadmill using a preloaded time trial. Med Sci Sports Exerc. 36:717-724, 2004.

2) Frisard, M.I., Fabre, J.M., Russell, R.D., King, C.M., DeLany, J.P., Wood, R.H., Ravussin, E.; for the

Louisiana Healthy Aging Study: Physical activity level and physical functionality in nonagenarians compared to individuals aged 60-74 years. J Gerontol A Biol Sci Med Sci. 62:783-788, 2007. PMCID: PMC2724866.

3) Larson-Meyer, D.E., Borkhsenious, O.N., Gullett, J.C., Russell, R.D., Devries, M.C., Smith, S.R., Ravussin, E.: Effect of dietary fat on serum and intramyocellular lipids and running performance. Med Sci Sports Exerc. 40:892-902, 2008. PMCID: PMC3182469.

4) Russell, R.D., Willis, K.S., Ravussin, E., Larson-Meyer E.D.: Effects of endurance running and dietary fat on circulating ghrelin and peptide YY. J Sports Sci Med. 8:574-583, 2009. PMCID: PMC3172724.

5) Russell, R.D., Nelson, A.G., Kraemer, R.R.: Metabolic dysfunction in diabetic offspring: deviations in metabolic flexibility. Med Sci Sports Exerc. 45(1):8-15, 2013. PMID: 22811035.

6) Zheng Y., Zhang L., Zeng Y., Fu M., Zhang D., Russell R.D.: Variants of NLRP3 gene are associated with insulin resistance in Chinese type-2 diabetic patients. Gene. 1;530(1):151-4, 2013. PMID: 23973723.

7) Russell, R.D., Nelson, A.G., Kraemer, R.R.: Short bouts of high-intensity resistance-style training produce similar reductions in fasting blood glucose of diabetic offspring and controls. J of Strength and Cond Research. Oct;28(10):2760-7, 2014. PMID: 25051004.

8) Zheng, Y., Russell, R.D., Zhang, D. Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients. Diabetes Research and Clinical Practice. Dec 5(106):312-318, 2014. PMID: 25238913.

9) Zheng, D., Zhang, L., Yue, F., Zheng, Y., Russell, RD. Serum zonulin is elevated in women with polycystic

ovary syndrome, and correlates with insulin resistance and severity of anovulation. European Journal of Endocrinology. 172:29-36, Jan 1, 2015. PMID: 25336505.

10) Zhang, L., Zhang, D., Zheng, Y., Hu, H., Zeng, Y., Yue, F., Russell, R.D. Association of NLRP3 gene

variants with metabolic syndrome in Chinese Han population. Pending review. MANUSCRIPTS IN PROGRESS Russell, R.D., Kraemer, R.R., Wong, K., McMillan R.P., Davis G.R., Van Dijk J.W., Kheterpal I., Nelson A.G., Roberts, C.K., Hulver M.W.: Changes in Lipotoxicity and Cardiovascular Disease Markers in Diabetic Offspring and Controls with Resistance Training. Russell, R.D., Premilovac, D., Rattigan, S., Keske, M.A.: Microvascular-linked metabolic inflexibility in adult offspring of type-2 diabetics. Russell, R.D., Richards, S.M., Kraemer, R.R., Keske, M.A.: Influence of Exercise on Oxidative Stress in Resting Glucoregulatory Function with Insulin Resistance and Type 2 Diabetes. Invited book chapter – Glucose Uptake. Russell, R.D., Blackwood, S.J., Rattigan, S., Keske, M.A.: Muscular and Cutaneous Microvascular Blood Flow in Forearm: Correlation between Contrast-Enhanced Ultrasound and Laser Doppler-Flow. Blackwood, S.J., Russell, R.D., Rattigan, S., Keske, M.A.: Relationship between Muscular Strength, Bone Density, and Cutaneous Microvascular Flux.

ABSTRACTS/PRESENTATIONS

1) Larson-Meyer, D.E., Frisard, M.I., Heilbronn, L.K., Newcomer, B.R., Russell, R.D., Ravussin, E., and The

Pennington CALERIE Group: Effect of 6-month calorie restriction and exercise on muscle and liver lipid in relation to insulin sensitivity. Obes Res 12 (Supplement):A5, 2004. (oral presentation)

2) Moreira, E.A., Heilbronn, L.K., Russell, R.D., DeLany, J.P., Ravussin, E.: Validation and reliability of

physical activity records and accelerometers by comparison with doubly labeled water. Obes Res 12 (Supplement):195, 2004. (poster)

3) Frisard, M.I., Larson-Meyer, D.E., Heilbronn, L.K., Newcomer, B.R., Russell, R.D., Ravussin, E.: Muscle

and liver lipid content in overweight subjects: effect of race and sex and relation to insulin sensitivity. Obes Res. 12 (Supplement):A32, 2004. (poster)

4) Larson-Meyer, D.E., Russell, R.D., Ravussin, E.: Effect of dietary fat on endurance performance and

cardiovascular risk factors in runners. Med Sci Sports Exerc. 37:276, 2005. (poster) 5) Russell, R.D., Ravussin, E., Larson-Meyer, D.E.: Effect of diet and intense running on plasma ghrelin and

PYY. Med Sci Sports Exerc. 38:S486-S487, 2006. (poster) 6) Wood, R.H., Ellis, R.G., McCarter, K.S., Fabre, J.M., Antikainen, I.E., Moore, D.S., Page, P., Russell,

R.D., Holton, F.B., Singh, S.: Socio-cultural factors and falls risk factors among independent-living older adults. Med Sci Sports Exerc. 39:S416, 2007. (poster)

7) Ellis, R., McCarter, K.S., Fabre, J.M., Antikainen, I.E., Moore, D.S., Page, P., Russell, R.D., Holton, F.B.,

Shivani, S., Wood, R.H.: Construct validity of a comprehensive falls risk screening instrument. Med Sci Sports Exerc. 39:S419, 2007. (poster)

8) Welsch, M.A., Dobrosielski, D.A., Arce-Esquivel, A.A., Russell, R.D., Ravussin, E., Frisard, M.I.: Daily

physical activity and brachial artery flow mediated dilation in older adults. Med Sci Sports Exerc 39 (Supplement):S20, 2007. (poster)

9) Russell, R.D., Credeur, D.P., Arce-Esquivel, A.A., Welsch, M.A., Francis, J., Mariappan, N., Changes in

pro- and anti-oxidants and vascular reactivity before and after acute exercise. Med Sci Sports Exerc. 40 (Supplement):S287, 2008. (poster)

10) Credeur, D.P., Russell, R.D., Welsch, M.A.: Brachial artery retrograde flow increases with age: Influence

on physical function. Med Sci Sports Exerc. 40 (Supplement):S308, 2008. (poster) 11) Holton, F., Ellis, R.G., Kosma, M., Cherry, K., Antikainen, I.E., Russell, R.D., Wood, R.H.: Predictors of

ADL disability in culturally diverse older adults. Med Sci Sports Exerc. 40(Supplement):S487, 2008. (poster)

12) Russell, R.D., Credeur, D.P., Dobrosielski, D.A., Parish, T.R., Welsch, M.A.: Changes in vascular and

physical function with exercise training in the aged. Med Sci Sports Exerc. 41:65-66 May 2009. (poster) 13) Russell, R.D., Credeur, D.P., Dobrosielski, D.A., Parish, T.R., Welsch, M.A., Jazwinski, S.M.: Changes in

vascular and physical function with exercise training in the oldest old. Southeast Chapter of American College of Sports Medicine Annual Meeting, 2009. (Oral presentation)

14) Credeur. D.P., Johansson, D., Russell, R.D., Dobrosielski, D.A., Arce-Esquivel, A.A., Ravussin, E, Welsch,

M.A.: Association between vascular structure, reactivity, and physical function: mediating role of homocysteine. Med Sci Sports Exerc. 43 (Supplement):S736, 2009. (poster)

15) Russell, R.D., Nelson, A.G.: Fasting blood-glucose changes in diabetic offspring and controls with seven

weeks of resistance training. Med Sci Sports Exerc. 42 (Supplement):S340, 2010. (poster) 16) Russell, R.D., Nelson, A.G., Kraemer, R.R.: Metabolic inflexibility: the link connecting diabetics with first

and second degree offspring of diabetes?. FASEB J 25:720.4, 2011. (poster) 17) Russell, R.D., Nelson, A.G., McMillan, R.P., Hulver, M.W., Davis, G.R., Van Dijk, J.W.: Reduced

lipotoxicity markers in diabetic offspring and controls with resistance training. Med Sci Sports Exerc. 43:559, 2011. (poster)

18) Davis, G.R., Russell, R.D., Nelson, A.G., Kokkonen, J.: Effects of acute cyclooxygenase inactivation on

glucose tolerance in diabetic offspring. Med. Sci. Sports Exerc. 43:559, 2011. (poster) 19) Wu, P.T., Russell, R.D., Thomas, A.P., Tse, C., Shadid, H.R., Thyfault, J.P., Roberts, C.K., FACSM.:

Effects of Low-Glycemic Load Diet and Resistance Training on Postprandial Glycemic Variability. Med Sci Sports Exerc. Ahead of print. ACSM Annual meeting, Orlando, Florida. 2014. (Poster)

20) Ryan D. Russell, Shadid, H.R., Thomas, A.P., Wu, P.T., Chronley, M.K., Tse, C., Popish, A.H., and

Roberts, C.K.: Resistance Training Improves Glycemic Control Independent of Dietary Glycemic Variation. Diabetes Supplement. Ahead of print. ADA Annual meeting, San Francisco, CA. 2014. (Poster)

INVITED LECTURES 2010 A Cursory Examination of Metabolic Dysfunction with Diabetes: Where Does it All Start? U.S. Army Research Institute for Environmental Medicine (USARIEM), Natick, MA. August 10th, 2010. Diabetes Metabolism, Where Does it All Start? Maastricht University, Maastricht, NL. November 30th, 2010. 2011 Impaired Metabolic Function in Healthy Diabetic Offspring: Deviations in Metabolic Flexibility. University of Maryland Medical School, Baltimore, MD. May 5th, 2011. 2013 Diabetes Metabolism: A Macro to Micro Approach. UCLA, Exercise and Metabolic Disease Laboratory. June 4th, 2013. Diabetes Metabolism: A Macro to Micro Approach. University of Michigan, Dept. of Kinesiology, Anne Arbor, MI. Aug 7th, 2013. 2014 A Translational Approach to Cardiometabolic Syndrome: From Molecule to Man. Auburn University at Montgomery, Dept. of Kinesiology, Montgomery, AL. July 15th, 2014. 2015 A Familial Model of Microvascular Inflexibility. Menzies Institute for Medical Research, 21 Liverpool Street, Hobart, TAS Australia. June 25, 2015. SERVICE

MANUSCRIPT REVIEWER Experimental Gerontology Journal of Science and Medicine in Sport Journal of Sports Science and Medicine Sports Medicine Medicine and Science in Sports and Exercise

SERVICE TO THE UNIVERSITY/COMMUNITY Committee member of the Medical Science Precinct Health and Wellness Committee, and chair of the Menzies Community Outreach Exercise Initiative.