rose hips drug interactions,dr.mohammad baghaei

Dr.Mohammad Baghaei, Pharmacist, Cosmetic Scientist

Rose hips drug interactions

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Rose hips drug interactions Dr.Mohammad Baghaei, Pharmacist, Cosmetic Scientist

The rose hip, also known as rose haw or rose hep, is the fruit of the rose plant that is typically red-to-orange, but ranges from dark purple to black in some species. Rose hips begin to form after successful pollination of flowers in spring or early summer, and ripen in late summer through autumn.

Rose hips are particularly high in vitamin c, one of the richest plant sources available. However, rp-hplc assays of fresh rose hips and several commercially available products revealed a wide range of l-ascorbic acid (vitamin c) content, ranging from 0.03 to 1.3%. Rose hips of some species, especially rosa canina (dog rose) and r. Majalis, have been used as a source of vitamin c.

Rose hips contain the carotenoids beta-carotene, lutein, zeaxanthin and lycopene, which are under basic research for a variety of potential biological roles, such as inhibiting oxidation of low density lipoprotein.

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Mechanism of Action

Antioxidant, unique water-soluble nutrient able to scavenge certain types of free radicals before they have a chance to damage lipids and other cellular components.

Shown to work along side of vitamin E, a fat-soluble antioxidant, and the enzyme glutathione peroxidase to stop the free radical chain reactions from getting out of hand

Suggested uses

Rich source of vitamin c, with about 1700-2000 mg per 100 g in dried product

Remedy for rheumatoid arthritis

Reduces symptoms of knee & hip osteoarthritis

Helps the immune system to fight off foreign invaders & out of control cells

Facilitates fat metabolism

Protects tissues from free radical damage

Assists the nervous system by converting certain amino acids into neurotransmitters

Prevents scurvy

Protects joints and connective tissues

Protects adrenal function

Ability to prevent urinary bladder infections, & assist in treating dizziness & headaches

Used externally in oil form to restore firmness to skin by nourishing & astringing tissue

Brewed into a decoction, can also be used to treat constipation

Rose hips contain lots of iron, rose hip tea is used during menstruation to make up for iron loss



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Rose hips drug

interactions

Serious interactions - use alternative (14)

Demeclocycline

Rose hips decreases levels of demeclocycline by inhibition of gi

absorption. Applies only to oral form of both agents. Avoid or use

alternate drug.

Doxycycline

Rose hips decreases levels of doxycycline by inhibition of gi absorption.

Applies only to oral form of both agents. Avoid or use alternate drug.



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Eltrombopag

Rose hips decreases levels of eltrombopag by inhibition of gi absorption.

Applies only to oral form of both agents. Contraindicated. Separate by at

least 4 hours.

Fleroxacin

Rose hips decreases levels of fleroxacin by inhibition of gi absorption.


Gemifloxacin

Rose hips decreases levels of gemifloxacin by inhibition of gi absorption.


Levofloxacin

Rose hips decreases levels of levofloxacin by inhibition of gi absorption.


Lymecycline

Rose hips decreases levels of lymecycline by inhibition of gi absorption.


Minocycline

Rose hips decreases levels of minocycline by inhibition of gi absorption.


Moxifloxacin

Rose hips decreases levels of moxifloxacin by inhibition of gi absorption.


Mycophenolate

Rose hips decreases levels of mycophenolate by inhibition of gi

absorption. Applies only to oral form of both agents. Avoid or use

alternate drug. Interaction only with oral iron administration.



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Norfloxacin

Rose hips decreases levels of norfloxacin by inhibition of gi absorption.


Ofloxacin

Rose hips decreases levels of ofloxacin by inhibition of GI absorption.

Applies only to oral form of both agents. Avoid or Use Alternate Drug.

Oxytetracycline

Rose hips decreases levels of oxytetracycline by inhibition of GI

absorption. Applies only to oral form of both agents. Avoid or Use

Alternate Drug

Tetracycline

Rose hips decreases levels of tetracycline by inhibition of gi absorption.


Monitor closely (38)

Aluminum hydroxide

Aluminum hydroxide will decrease the level or effect of rose hips by

increasing gastric ph. Applies only to oral form of both agents. Use

caution/monitor.

Amoxicillin

Amoxicillin, rose hips. Either increases levels of the other by decreasing

renal clearance. Use caution/monitor.



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Ampicillin

Ampicillin, rose hips. Either increases levels of the other by decreasing


Calcium carbonate

Calcium carbonate will decrease the level or effect of rose hips by


caution/monitor.

Cimetidine

Cimetidine will decrease the level or effect of rose hips by increasing

gastric ph. Applies only to oral form of both agents. Use

caution/monitor.

Deferiprone

Deferiprone decreases levels of rose hips by inhibition of gi absorption.

Applies only to oral form of both agents. Use caution/monitor.

Deferiprone chelates iron.

Deferoxamine

Deferoxamine, rose hips. Other (see comment). Use caution/monitor.

Comment: ascorbic acid increases the availability of iron for chelation

with deferoxamine. Ascorbic acid should be avoided in pts. With cardiac

failure undergoing deferoxamine tx. Clinical cardiac monitoring

recommended for pts. Supplemented with ascorbic acid.

Deferoxamine decreases levels of rose hips by inhibition of gi

absorption. Applies only to oral form of both agents. Use

caution/monitor. Deferoxamine chelates iron.

Dexlansoprazole

Dexlansoprazole will decrease the level or effect of rose hips by


caution/monitor.



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Enalapril

Enalapril, rose hips. Mechanism: unknown. Use caution/monitor. Risk of

gi symptoms, hypotension.

Esomeprazole

Esomeprazole will decrease the level or effect of rose hips by increasing


caution/monitor.

Famotidine

Famotidine will decrease the level or effect of rose hips by increasing


caution/monitor.

Flucloxacillin

Flucloxacillin, rose hips. Either increases levels of the other by

decreasing renal clearance. Use caution/monitor.

Ibandronate

Rose hips decreases levels of ibandronate by inhibition of gi absorption.


Lansoprazole

Lansoprazole will decrease the level or effect of rose hips by increasing


caution/monitor.

Levothyroxine

Rose hips decreases levels of levothyroxine by inhibition of gi


caution/monitor.

Liothyronine

Rose hips decreases levels of liothyronine by inhibition of gi absorption.




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Methotrexate

Rose hips will increase the level or effect of methotrexate by acidic

(anionic) drug competition for renal tubular clearance. Use

caution/monitor.

Methyldopa

Rose hips decreases levels of methyldopa by inhibition of gi absorption.


Mycophenolate

Rose hips will increase the level or effect of mycophenolate by acidic


caution/monitor.

Nafcillin

Nafcillin, rose hips. Either increases levels of the other by decreasing


Nizatidine

Nizatidine will decrease the level or effect of rose hips by increasing


caution/monitor.

Omeprazole

Omeprazole will decrease the level or effect of rose hips by increasing


caution/monitor.

Oxacillin

Oxacillin, rose hips. Either increases levels of the other by decreasing




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Pantoprazole

Pantoprazole will decrease the level or effect of rose hips by increasing


caution/monitor.

Penicillamine

Rose hips decreases levels of penicillamine by inhibition of gi


caution/monitor. Interaction only with oral iron administration.

Penicillin g aqueous

Penicillin g aqueous, rose hips. Either increases levels of the other by


Penicillin vk

Penicillin vk, rose hips. Either increases levels of the other by decreasing


Pivmecillinam

Pivmecillinam, rose hips. Either increases levels of the other by


Probenecid

Rose hips will increase the level or effect of probenecid by acidic


caution/monitor.

Rabeprazole

Rabeprazole will decrease the level or effect of rose hips by increasing


caution/monitor.



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Ranitidine

Ranitidine will decrease the level or effect of rose hips by increasing


caution/monitor.

Sodium bicarbonate

Sodium bicarbonate will decrease the level or effect of rose hips by


caution/monitor.

Sodium citrate/citric acid

Sodium citrate/citric acid will decrease the level or effect of rose hips by


caution/monitor.

Temocillin

Temocillin, rose hips. Either increases levels of the other by decreasing


Thyroid desiccated

Rose hips decreases levels of thyroid desiccated by inhibition of gi


caution/monitor.

Ticarcillin

Ticarcillin, rose hips. Either increases levels of the other by decreasing


Trientine

Trientine, rose hips. Either decreases levels of the other by inhibition of

gi absorption. Applies only to oral form of both agents. Use

caution/monitor. Separate by 2 hr.



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Wheat germ extract

Rose hips decreases effects of wheat germ extract by unknown

mechanism. Use caution/monitor. Mfr. Recommends separating by 2

hrs.

Minor IN (113)

Aceclofenac

Rose hips will increase the level or effect of aceclofenac by acidic

(anionic) drug competition for renal tubular clearance.

Minor/significance unknown.

Acemetacin

Rose hips will increase the level or effect of acemetacin by acidic



Acetohydroxamic acid

Acetohydroxamic acid decreases levels of rose hips by inhibition of gi

absorption. Applies only to oral form of both agents. Minor/significance

unknown.

Acyclovir

Rose hips will increase the level or effect of acyclovir by acidic (anionic)

drug competition for renal tubular clearance. Minor/significance

unknown.

Aluminum hydroxide

Rose hips increases levels of aluminum hydroxide by enhancing gi


unknown.



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Aminohippurate sodium

Rose hips will increase the level or effect of aminohippurate sodium by

acidic (anionic) drug competition for renal tubular clearance.


Amobarbital

Amobarbital decreases levels of rose hips by increasing elimination.


Ascorbic acid

Ascorbic acid will increase the level or effect of rose hips by acidic



Aspirin

Rose hips will increase the level or effect of aspirin by acidic (anionic)


unknown.

Aspirin decreases levels of rose hips by increasing renal clearance.


Rose hips increases levels of aspirin by decreasing renal clearance.


Aspirin rectal

Rose hips will increase the level or effect of aspirin rectal by acidic



Rose hips increases levels of aspirin rectal by decreasing renal

clearance. Minor/significance unknown.

Aspirin rectal decreases levels of rose hips by increasing renal clearance.


Aspirin/citric acid/sodium bicarbonate

Aspirin/citric acid/sodium bicarbonate decreases levels of rose hips by

increasing renal clearance. Minor/significance unknown.

Rose hips will increase the level or effect of aspirin/citric acid/sodium



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bicarbonate by acidic (anionic) drug competition for renal tubular


Rose hips increases levels of aspirin/citric acid/sodium bicarbonate by

decreasing renal clearance. Minor/significance unknown.

Balsalazide

Rose hips will increase the level or effect of balsalazide by acidic



Balsalazide decreases levels of rose hips by increasing renal clearance.


Rose hips increases levels of balsalazide by decreasing renal clearance.


Bazedoxifene/conjugated estrogens

Bazedoxifene/conjugated estrogens decreases levels of rose hips by

increasing elimination. Minor/significance unknown.

Bendroflumethiazide

Rose hips will increase the level or effect of bendroflumethiazide by



Butabarbital

Butabarbital decreases levels of rose hips by increasing elimination.


Butalbital

Butalbital decreases levels of rose hips by increasing elimination.


Calcium acetate

Calcium acetate decreases levels of rose hips by inhibition of gi


unknown.



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Rose hips increases levels of calcium acetate by enhancing gi absorption.

Applies only to oral form of both agents. Minor/significance unknown.

Calcium carbonate

Calcium carbonate decreases levels of rose hips by inhibition of gi


unknown.

Rose hips increases levels of calcium carbonate by enhancing gi


unknown.

Calcium chloride

Calcium chloride decreases levels of rose hips by inhibition of gi


unknown.

Rose hips increases levels of calcium chloride by enhancing gi


unknown.

Calcium citrate

Calcium citrate decreases levels of rose hips by inhibition of gi


unknown.

Rose hips increases levels of calcium citrate by enhancing gi absorption.


Calcium gluconate

Calcium gluconate decreases levels of rose hips by inhibition of gi


unknown.

Rose hips increases levels of calcium gluconate by enhancing gi


unknown.



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Cefaclor

Rose hips will increase the level or effect of cefaclor by acidic (anionic)


unknown.

Cefadroxil

Rose hips will increase the level or effect of cefadroxil by acidic (anionic)


unknown.

Cefamandole

Rose hips will increase the level or effect of cefamandole by acidic



Cefazolin

Rose hips will increase the level or effect of cefazolin by acidic (anionic)


unknown.

Cefdinir

Rose hips will increase the level or effect of cefdinir by acidic (anionic)


unknown.

Cefditoren

Rose hips will increase the level or effect of cefditoren by acidic



Cefepime

Rose hips will increase the level or effect of cefepime by acidic (anionic)


unknown.



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Cefixime

Rose hips will increase the level or effect of cefixime by acidic (anionic)


unknown.

Cefotaxime

Rose hips will increase the level or effect of cefotaxime by acidic



Cefotetan

Rose hips will increase the level or effect of cefotetan by acidic (anionic)


unknown.

Cefoxitin

Rose hips will increase the level or effect of cefoxitin by acidic (anionic)


unknown.

Cefpirome

Rose hips will increase the level or effect of cefpirome by acidic



Cefpodoxime

Rose hips will increase the level or effect of cefpodoxime by acidic



Cefprozil

Rose hips will increase the level or effect of cefprozil by acidic (anionic)


unknown.



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Ceftazidime

Rose hips will increase the level or effect of ceftazidime by acidic



Ceftibuten

Rose hips will increase the level or effect of ceftibuten by acidic



Ceftizoxime

Rose hips will increase the level or effect of ceftizoxime by acidic



Ceftriaxone

Rose hips will increase the level or effect of ceftriaxone by acidic



Cefuroxime

Rose hips will increase the level or effect of cefuroxime by acidic



Celecoxib

Rose hips will increase the level or effect of celecoxib by acidic (anionic)


unknown.

Cephalexin

Rose hips will increase the level or effect of cephalexin by acidic





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Chlorothiazide

Rose hips will increase the level or effect of chlorothiazide by acidic



Chlorpropamide

Rose hips will increase the level or effect of chlorpropamide by acidic



Chlorthalidone

Rose hips will increase the level or effect of chlorthalidone by acidic



Choline magnesium trisalicylate

Choline magnesium trisalicylate decreases levels of rose hips by

increasing renal clearance. Minor/significance unknown.

Rose hips will increase the level or effect of choline magnesium

trisalicylate by acidic (anionic) drug competition for renal tubular


Rose hips increases levels of choline magnesium trisalicylate by

decreasing renal clearance. Minor/significance unknown.

Chromium

Rose hips increases levels of chromium by enhancing gi absorption.


Conjugated estrogens

Conjugated estrogens decreases levels of rose hips by increasing

elimination. Minor/significance unknown.

Conjugated estrogens, vaginal

Conjugated estrogens, vaginal decreases levels of rose hips by increasing




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Copper

Rose hips decreases levels of copper by inhibition of gi absorption.


Cyanocobalamin

Rose hips decreases levels of cyanocobalamin by inhibition of gi


unknown.

Cyclopenthiazide

Rose hips will increase the level or effect of cyclopenthiazide by acidic



Demeclocycline

Demeclocycline decreases levels of rose hips by increasing elimination.


Diclofenac

Rose hips will increase the level or effect of diclofenac by acidic



Didanosine

Didanosine will decrease the level or effect of rose hips by increasing

gastric ph. Applies only to oral form of both agents. Minor/significance

unknown.

Diflunisal

Rose hips will increase the level or effect of diflunisal by acidic (anionic)


unknown.

Diflunisal decreases levels of rose hips by increasing renal clearance.




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Rose hips increases levels of diflunisal by decreasing renal clearance.


Doxycycline

Doxycycline decreases levels of rose hips by increasing elimination.


Estradiol

Estradiol decreases levels of rose hips by increasing elimination.


Estrogens conjugated synthetic

Estrogens conjugated synthetic decreases levels of rose hips by

increasing elimination. Minor/significance unknown.

Estrogens esterified

Estrogens esterified decreases levels of rose hips by increasing


Estropipate

Estropipate decreases levels of rose hips by increasing elimination.


Etodolac

Rose hips will increase the level or effect of etodolac by acidic (anionic)


unknown.

Etoricoxib

Rose hips will increase the level or effect of etoricoxib by acidic





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Fenbufen

Rose hips will increase the level or effect of fenbufen by acidic (anionic)


unknown.

Fenoprofen

Rose hips will increase the level or effect of fenoprofen by acidic



Flurbiprofen

Rose hips will increase the level or effect of flurbiprofen by acidic



Ganciclovir

Rose hips will increase the level or effect of ganciclovir by acidic



Gymnema

Gymnema decreases levels of rose hips by inhibition of gi absorption.


Hexobarbital

Hexobarbital decreases levels of rose hips by increasing elimination.


Hydrochlorothiazide

Rose hips will increase the level or effect of hydrochlorothiazide by





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Ibuprofen

Rose hips will increase the level or effect of ibuprofen by acidic (anionic)


unknown.

Indapamide

Rose hips will increase the level or effect of indapamide by acidic



Indomethacin

Rose hips will increase the level or effect of indomethacin by acidic



Ketoprofen

Rose hips will increase the level or effect of ketoprofen by acidic



Ketorolac

Rose hips will increase the level or effect of ketorolac by acidic (anionic)


unknown.

Ketorolac intranasal

Rose hips will increase the level or effect of ketorolac intranasal by



Levocarnitine

Rose hips decreases levels of levocarnitine by unspecified interaction

mechanism. Minor/significance unknown.



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Lornoxicam

Rose hips will increase the level or effect of lornoxicam by acidic



Lymecycline

Lymecycline decreases levels of rose hips by increasing elimination.


Manganese

Rose hips decreases levels of manganese by inhibition of gi absorption.


Meclofenamate

Rose hips will increase the level or effect of meclofenamate by acidic



Mefenamic acid

Rose hips will increase the level or effect of mefenamic acid by acidic



Meloxicam

Rose hips will increase the level or effect of meloxicam by acidic



Mephobarbital

Mephobarbital decreases levels of rose hips by increasing elimination.


Mesalamine

Rose hips will increase the level or effect of mesalamine by acidic




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Mesalamine decreases levels of rose hips by increasing renal clearance.


Rose hips increases levels of mesalamine by decreasing renal clearance.


Mestranol

Mestranol decreases levels of rose hips by increasing elimination.


Methyclothiazide

Rose hips will increase the level or effect of methyclothiazide by acidic



Metolazone

Rose hips will increase the level or effect of metolazone by acidic



Minocycline

Minocycline decreases levels of rose hips by increasing elimination.


Nabumetone

Rose hips will increase the level or effect of nabumetone by acidic



Naproxen

Rose hips will increase the level or effect of naproxen by acidic (anionic)


unknown.



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Nicotine inhaled

Nicotine inhaled decreases levels of rose hips by increasing elimination.


Nicotine intranasal

Nicotine intranasal decreases levels of rose hips by increasing


Oxaprozin

Rose hips will increase the level or effect of oxaprozin by acidic



Oxytetracycline

Oxytetracycline decreases levels of rose hips by increasing elimination.


Parecoxib

Rose hips will increase the level or effect of parecoxib by acidic (anionic)


unknown.

Pentobarbital

Pentobarbital decreases levels of rose hips by increasing elimination.


Phenobarbital

Phenobarbital decreases levels of rose hips by increasing elimination.


Piperacillin

Rose hips will increase the level or effect of piperacillin by acidic





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Piroxicam

Rose hips will increase the level or effect of piroxicam by acidic



Primidone

Primidone decreases levels of rose hips by increasing elimination.


Salicylates (non-asa)

Rose hips will increase the level or effect of salicylates (non-asa) by



Salicylates (non-asa) decreases levels of rose hips by increasing renal


Rose hips increases levels of salicylates (non-asa) by decreasing renal


Salsalate

Rose hips will increase the level or effect of salsalate by acidic (anionic)


unknown.

Salsalate decreases levels of rose hips by increasing renal clearance.


Rose hips increases levels of salsalate by decreasing renal clearance.


Secobarbital

Secobarbital decreases levels of rose hips by increasing elimination.


Sulfasalazine

Rose hips will increase the level or effect of sulfasalazine by acidic



Sulfasalazine decreases levels of rose hips by increasing renal clearance.



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Rose hips increases levels of sulfasalazine by decreasing renal clearance.


Sulindac

Rose hips will increase the level or effect of sulindac by acidic (anionic)


unknown.

Tetracycline

Tetracycline decreases levels of rose hips by increasing elimination.


Tolfenamic acid

Rose hips will increase the level or effect of tolfenamic acid by acidic



Tolmetin

Rose hips will increase the level or effect of tolmetin by acidic (anionic)


unknown.

Valganciclovir

Rose hips will increase the level or effect of valganciclovir by acidic



Vitamin E

Vitamin E decreases levels of rose hips by inhibition of gi absorption.


Warfarin

Rose hips decreases effects of warfarin by pharmacodynamic

antagonism. Minor/significance unknown. Dose >10 g/day vitamin c.



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Willow bark

Rose hips will increase the level or effect of willow bark by acidic



Willow bark decreases levels of rose hips by increasing renal clearance.


Rose hips increases levels of willow bark by decreasing renal clearance.


rose hips drug interactions,dr.mohammad baghaei

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